PARADIGM pathway analysis of mRNASeq expression and copy number data
Colorectal Adenocarcinoma (Primary solid tumor)
15 January 2014  |  analyses__2014_01_15
Maintainer Information
Citation Information
doi:10.7908/C1GX492V
Maintained by Dan DiCara (Broad Institute)
Cite as Broad Institute TCGA Genome Data Analysis Center (2014): PARADIGM pathway analysis of mRNASeq expression and copy number data. Broad Institute of MIT and Harvard. doi:10.7908/C1GX492V
Overview
Introduction

PAthway Representation and Analysis by Direct Inference on Graphical Models (PARADIGM) predicts the activity of a diverse set of molecular concepts such as genes, complexes, and processes. The predicted activities are called Inferred Pathway Levels (IPLs) and are derived from a probabilistic belief propagation strategy that incorporates multimodal data such as copy number and gene expression estimates with a concept's pathway context.

Summary

There were 38 significant pathways identified in this analysis.

Table 1.  Get Full Table Top 10 out of 131 pathways in order of significance.

Pathway.Name Avg.Num.Perturbations
Signaling mediated by p38-alpha and p38-beta 83
IL23-mediated signaling events 76
IL4-mediated signaling events 73
FOXA2 and FOXA3 transcription factor networks 52
Endothelins 50
Wnt signaling 47
Signaling events mediated by the Hedgehog family 46
TCR signaling in naïve CD8+ T cells 46
Osteopontin-mediated events 45
Noncanonical Wnt signaling pathway 45
Results
Summary Table

The following list describes the columns found in Table 2.

  • Pathway.Name = Full pathway name of curated PARADIGM pathway

  • Significance.Ratio = (Ave.Num.Perturbations)/ (Cohort Size) where Cohort Size is 574 . Pathway is significant if Significance.Ratio > 0.05 .

  • Avg.Num.Perturbations = Average number of samples with perturbations across the pathway concepts determined by a background permutation model (>2 standard deviations away from the permuted distribution)

  • Total.Perturbations = Total number of perturbed concepts across all samples (>2 standard deviations away from the permuted distribution)

  • Num.Entities = Number of concepts that belong to the pathway

  • Min.Mean.Truth = Minimum IPL for concepts in the pathway among real samples

  • Max.Mean.Truth = Maximum IPL for concepts in the pathway among real samples

  • Min.Mean.Within = Minimum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Max.Mean.Within = Maximum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Min.Mean.Any = Minimum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes)

  • Max.Mean.Any = Maximum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes).

Table 2.  Get Full Table This summary table provides a report of cancer type specific pathway perturbations. Click on the links in the first column to display more detailed results for each pathway. A pathway is defined as significant (red number in Significance.Ratio column) if the Ave.Num.Perturbationsis > 5% of the cohort size ( 574 ).

Pathway.Name Significance.Ratio Avg.Num.Perturbations Total.Perturbations Num.Entities Min.Mean.Truth Max.Mean.Truth Min.Mean.Within Max.Mean.Within Min.Mean.Any Max.Mean.Within.1
Signaling mediated by p38-alpha and p38-beta 0.1446 83 3688 44 -0.12 0.026 1000 -1000 -0.02 -1000
IL23-mediated signaling events 0.1324 76 4589 60 -0.41 0.026 1000 -1000 -0.1 -1000
IL4-mediated signaling events 0.1272 73 6672 91 -0.56 0.47 1000 -1000 -0.12 -1000
FOXA2 and FOXA3 transcription factor networks 0.0906 52 2403 46 -0.27 0.027 1000 -1000 -0.1 -1000
Endothelins 0.0871 50 4845 96 -0.12 0.03 1000 -1000 -0.048 -1000
Wnt signaling 0.0819 47 335 7 -0.071 0.019 1000 -1000 -0.013 -1000
Signaling events mediated by the Hedgehog family 0.0801 46 2396 52 -0.055 0.039 1000 -1000 -0.032 -1000
TCR signaling in naïve CD8+ T cells 0.0801 46 4319 93 -0.085 0.039 1000 -1000 -0.044 -1000
Osteopontin-mediated events 0.0784 45 1710 38 -0.083 0.03 1000 -1000 -0.042 -1000
Noncanonical Wnt signaling pathway 0.0784 45 1175 26 -0.074 0.025 1000 -1000 -0.045 -1000
HIF-1-alpha transcription factor network 0.0784 45 3495 76 -0.15 0.029 1000 -1000 -0.072 -1000
Fc-epsilon receptor I signaling in mast cells 0.0784 45 4433 97 -0.14 0.048 1000 -1000 -0.051 -1000
Ephrin B reverse signaling 0.0784 45 2166 48 -0.098 0.038 1000 -1000 -0.024 -1000
Reelin signaling pathway 0.0732 42 2371 56 -0.065 0.067 1000 -1000 -0.04 -1000
TCGA08_p53 0.0732 42 298 7 -0.032 0.025 1000 -1000 -0.015 -1000
IL12-mediated signaling events 0.0714 41 3626 87 -0.21 0.038 1000 -1000 -0.07 -1000
Glypican 1 network 0.0697 40 1930 48 -0.077 0.047 1000 -1000 -0.029 -1000
BCR signaling pathway 0.0697 40 4011 99 -0.13 0.029 1000 -1000 -0.039 -1000
amb2 Integrin signaling 0.0645 37 3048 82 -0.082 0.034 1000 -1000 -0.036 -1000
Ephrin A reverse signaling 0.0627 36 258 7 -0.04 0.009 1000 -1000 -0.018 -1000
LPA receptor mediated events 0.0627 36 3715 102 -0.068 0.031 1000 -1000 -0.06 -1000
EGFR-dependent Endothelin signaling events 0.0627 36 762 21 -0.049 0.039 1000 -1000 -0.04 -1000
Syndecan-4-mediated signaling events 0.0627 36 2415 67 -0.063 0.039 1000 -1000 -0.033 -1000
Syndecan-1-mediated signaling events 0.0592 34 1179 34 -0.043 0.026 1000 -1000 -0.037 -1000
IL1-mediated signaling events 0.0592 34 2139 62 -0.047 0.091 1000 -1000 -0.054 -1000
TCGA08_retinoblastoma 0.0592 34 277 8 -0.007 0.029 1000 -1000 -0.006 -1000
Thromboxane A2 receptor signaling 0.0575 33 3505 105 -0.081 0.035 1000 -1000 -0.046 -1000
Nephrin/Neph1 signaling in the kidney podocyte 0.0557 32 1088 34 -0.036 0.048 1000 -1000 -0.027 -1000
p75(NTR)-mediated signaling 0.0557 32 4002 125 -0.063 0.065 1000 -1000 -0.066 -1000
Glucocorticoid receptor regulatory network 0.0540 31 3539 114 -0.23 0.12 1000 -1000 -0.051 -1000
Signaling events regulated by Ret tyrosine kinase 0.0540 31 2596 82 -0.049 0.034 1000 -1000 -0.045 -1000
Signaling events mediated by Stem cell factor receptor (c-Kit) 0.0540 31 2471 78 -0.14 0.033 1000 -1000 -0.04 -1000
JNK signaling in the CD4+ TCR pathway 0.0523 30 511 17 -0.043 0.029 1000 -1000 -0.029 -1000
EPHB forward signaling 0.0523 30 2606 85 -0.047 0.081 1000 -1000 -0.057 -1000
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 0.0523 30 2067 68 -0.16 0.06 1000 -1000 -0.07 -1000
PDGFR-beta signaling pathway 0.0523 30 2931 97 -0.086 0.076 1000 -1000 -0.052 -1000
Effects of Botulinum toxin 0.0505 29 769 26 -0.066 0.035 1000 -1000 -0.015 -1000
Calcium signaling in the CD4+ TCR pathway 0.0505 29 914 31 -0.073 0.027 1000 -1000 -0.037 -1000
BMP receptor signaling 0.0470 27 2243 81 -0.051 0.041 1000 -1000 -0.034 -1000
Angiopoietin receptor Tie2-mediated signaling 0.0470 27 2454 88 -0.055 0.039 1000 -1000 -0.051 -1000
VEGFR1 specific signals 0.0436 25 1446 56 -0.002 0.081 1000 -1000 -0.038 -1000
Visual signal transduction: Rods 0.0436 25 1300 52 -0.049 0.041 1000 -1000 -0.028 -1000
Nongenotropic Androgen signaling 0.0418 24 1275 52 -0.028 0.047 1000 -1000 -0.03 -1000
IGF1 pathway 0.0418 24 1418 57 -0.038 0.052 1000 -1000 -0.038 -1000
Plasma membrane estrogen receptor signaling 0.0418 24 2113 86 -0.034 0.076 1000 -1000 -0.044 -1000
Neurotrophic factor-mediated Trk receptor signaling 0.0418 24 2950 120 -0.079 0.072 1000 -1000 -0.039 -1000
Caspase cascade in apoptosis 0.0401 23 1769 74 -0.056 0.053 1000 -1000 -0.037 -1000
Syndecan-2-mediated signaling events 0.0401 23 1650 69 -0.027 0.039 1000 -1000 -0.034 -1000
IFN-gamma pathway 0.0401 23 1573 68 -0.05 0.037 1000 -1000 -0.051 -1000
Retinoic acid receptors-mediated signaling 0.0401 23 1375 58 -0.038 0.047 1000 -1000 -0.043 -1000
Integrins in angiogenesis 0.0401 23 1950 84 -0.082 0.055 1000 -1000 -0.045 -1000
Cellular roles of Anthrax toxin 0.0383 22 864 39 -0.029 0.025 1000 -1000 -0.021 -1000
Arf6 signaling events 0.0383 22 1366 62 -0.05 0.058 1000 -1000 -0.03 -1000
Presenilin action in Notch and Wnt signaling 0.0383 22 1342 61 -0.04 0.065 1000 -1000 -0.044 -1000
Ceramide signaling pathway 0.0383 22 1702 76 -0.039 0.066 1000 -1000 -0.037 -1000
FAS signaling pathway (CD95) 0.0383 22 1069 47 -0.12 0.041 1000 -1000 -0.025 -1000
Canonical Wnt signaling pathway 0.0383 22 1146 51 -0.1 0.079 1000 -1000 -0.045 -1000
IL6-mediated signaling events 0.0383 22 1659 75 -0.038 0.046 1000 -1000 -0.05 -1000
a4b1 and a4b7 Integrin signaling 0.0366 21 106 5 0.006 0.024 1000 -1000 0.012 -1000
Ras signaling in the CD4+ TCR pathway 0.0366 21 360 17 -0.018 0.039 1000 -1000 -0.025 -1000
Lissencephaly gene (LIS1) in neuronal migration and development 0.0348 20 1114 54 -0.045 0.035 1000 -1000 -0.038 -1000
Class I PI3K signaling events 0.0348 20 1516 73 -0.063 0.03 1000 -1000 -0.038 -1000
ErbB2/ErbB3 signaling events 0.0331 19 1296 65 -0.054 0.039 1000 -1000 -0.062 -1000
IL27-mediated signaling events 0.0331 19 982 51 -0.11 0.027 1000 -1000 -0.049 -1000
Signaling events mediated by PTP1B 0.0314 18 1399 76 -0.049 0.044 1000 -1000 -0.033 -1000
S1P1 pathway 0.0314 18 680 36 -0.055 0.038 1000 -1000 -0.033 -1000
Glypican 2 network 0.0314 18 72 4 0.013 0.024 1000 -1000 0.012 -1000
FOXM1 transcription factor network 0.0314 18 940 51 -0.11 0.046 1000 -1000 -0.11 -1000
S1P4 pathway 0.0314 18 458 25 -0.016 0.036 1000 -1000 -0.022 -1000
Paxillin-independent events mediated by a4b1 and a4b7 0.0296 17 659 37 -0.024 0.053 1000 -1000 -0.025 -1000
Visual signal transduction: Cones 0.0279 16 632 38 -0.019 0.04 1000 -1000 -0.029 -1000
EPO signaling pathway 0.0279 16 897 55 -0.016 0.06 1000 -1000 -0.035 -1000
PDGFR-alpha signaling pathway 0.0279 16 709 44 -0.032 0.057 1000 -1000 -0.039 -1000
Regulation of p38-alpha and p38-beta 0.0279 16 872 54 -0.065 0.05 1000 -1000 -0.044 -1000
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 0.0261 15 1281 85 -0.056 0.046 1000 -1000 -0.039 -1000
RXR and RAR heterodimerization with other nuclear receptor 0.0261 15 810 52 -0.026 0.075 1000 -1000 -0.034 -1000
LPA4-mediated signaling events 0.0244 14 170 12 -0.044 0 1000 -1000 -0.024 -1000
Syndecan-3-mediated signaling events 0.0244 14 511 35 -0.017 0.065 1000 -1000 -0.023 -1000
Regulation of Androgen receptor activity 0.0244 14 1028 70 -0.14 0.057 1000 -1000 -0.036 -1000
Aurora B signaling 0.0244 14 991 67 -0.16 0.061 1000 -1000 -0.029 -1000
Coregulation of Androgen receptor activity 0.0226 13 1062 76 -0.11 0.053 1000 -1000 -0.023 -1000
Class I PI3K signaling events mediated by Akt 0.0226 13 892 68 -0.044 0.051 1000 -1000 -0.028 -1000
HIV-1 Nef: Negative effector of Fas and TNF-alpha 0.0226 13 620 45 -0.035 0.068 1000 -1000 -0.041 -1000
IL2 signaling events mediated by STAT5 0.0226 13 290 22 -0.03 0.027 1000 -1000 -0.043 -1000
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 0.0226 13 435 33 -0.008 0.063 1000 -1000 -0.032 -1000
Arf6 downstream pathway 0.0209 12 526 43 -0.029 0.039 1000 -1000 -0.03 -1000
mTOR signaling pathway 0.0209 12 671 53 -0.072 0.029 1000 -1000 -0.028 -1000
Nectin adhesion pathway 0.0209 12 816 63 -0.012 0.07 1000 -1000 -0.048 -1000
S1P5 pathway 0.0209 12 204 17 -0.009 0.029 1000 -1000 -0.008 -1000
Paxillin-dependent events mediated by a4b1 0.0209 12 432 36 -0.041 0.043 1000 -1000 -0.03 -1000
IL2 signaling events mediated by PI3K 0.0209 12 723 58 -0.017 0.043 1000 -1000 -0.036 -1000
S1P3 pathway 0.0209 12 504 42 -0.018 0.042 1000 -1000 -0.037 -1000
PLK1 signaling events 0.0192 11 945 85 -0.008 0.057 1000 -1000 -0.022 -1000
Signaling mediated by p38-gamma and p38-delta 0.0192 11 178 15 -0.021 0.024 1000 -1000 -0.027 -1000
Arf6 trafficking events 0.0192 11 799 71 -0.042 0.045 1000 -1000 -0.027 -1000
Regulation of Telomerase 0.0192 11 1166 102 -0.058 0.05 1000 -1000 -0.048 -1000
Insulin Pathway 0.0192 11 815 74 -0.049 0.081 1000 -1000 -0.053 -1000
Signaling events mediated by PRL 0.0192 11 387 34 -0.021 0.076 1000 -1000 -0.04 -1000
Class IB PI3K non-lipid kinase events 0.0192 11 33 3 -0.017 0.017 1000 -1000 -0.009 -1000
Sphingosine 1-phosphate (S1P) pathway 0.0174 10 296 28 -0.024 0.041 1000 -1000 -0.027 -1000
Hedgehog signaling events mediated by Gli proteins 0.0174 10 665 65 -0.019 0.046 1000 -1000 -0.035 -1000
Insulin-mediated glucose transport 0.0174 10 335 32 -0.13 0.04 1000 -1000 -0.024 -1000
ceramide signaling pathway 0.0174 10 511 49 -0.002 0.036 1000 -1000 -0.039 -1000
Stabilization and expansion of the E-cadherin adherens junction 0.0174 10 771 74 -0.053 0.061 1000 -1000 -0.056 -1000
Sumoylation by RanBP2 regulates transcriptional repression 0.0174 10 293 27 -0.027 0.041 1000 -1000 -0.037 -1000
Regulation of nuclear SMAD2/3 signaling 0.0157 9 1344 136 -0.055 0.05 1000 -1000 -0.034 -1000
ErbB4 signaling events 0.0157 9 662 69 -0.074 0.05 1000 -1000 -0.04 -1000
Signaling events mediated by HDAC Class III 0.0157 9 378 40 -0.045 0.048 1000 -1000 -0.029 -1000
Role of Calcineurin-dependent NFAT signaling in lymphocytes 0.0157 9 817 83 -0.048 0.055 1000 -1000 -0.033 -1000
TCGA08_rtk_signaling 0.0157 9 254 26 -0.025 0.058 1000 -1000 -0.004 -1000
HIF-2-alpha transcription factor network 0.0139 8 345 43 -0.083 0.085 1000 -1000 -0.04 -1000
FoxO family signaling 0.0139 8 513 64 -0.064 0.062 1000 -1000 -0.053 -1000
E-cadherin signaling in the nascent adherens junction 0.0139 8 619 76 -0.013 0.08 1000 -1000 -0.052 -1000
BARD1 signaling events 0.0122 7 434 57 -0.028 0.065 1000 -1000 -0.037 -1000
Signaling events mediated by HDAC Class I 0.0122 7 730 104 -0.051 0.062 1000 -1000 -0.031 -1000
Signaling events mediated by VEGFR1 and VEGFR2 0.0122 7 955 125 -0.021 0.095 1000 -1000 -0.053 -1000
Signaling events mediated by HDAC Class II 0.0105 6 472 75 -0.023 0.07 1000 -1000 -0.031 -1000
Canonical NF-kappaB pathway 0.0087 5 214 39 -0.009 0.056 1000 -1000 -0.031 -1000
p38 MAPK signaling pathway 0.0087 5 221 44 -0.008 0.058 1000 -1000 -0.022 -1000
Arf1 pathway 0.0087 5 319 54 -0.004 0.04 1000 -1000 -0.015 -1000
Aurora C signaling 0.0070 4 33 7 0 0.033 1000 -1000 -0.015 -1000
PLK2 and PLK4 events 0.0052 3 9 3 -0.015 -1000 1000 -1000 -0.024 -1000
Atypical NF-kappaB pathway 0.0052 3 106 31 -0.01 0.048 1000 -1000 -0.025 -1000
Rapid glucocorticoid signaling 0.0052 3 64 20 -0.015 0.03 1000 -1000 -0.015 -1000
E-cadherin signaling in keratinocytes 0.0052 3 156 43 -0.039 0.08 1000 -1000 -0.029 -1000
Aurora A signaling 0.0035 2 169 60 -0.014 0.07 1000 -1000 -0.026 -1000
TRAIL signaling pathway 0.0035 2 112 48 -0.014 0.056 1000 -1000 -0.031 -1000
Regulation of cytoplasmic and nuclear SMAD2/3 signaling 0.0017 1 27 23 0.012 0.037 1000 -1000 -0.024 -1000
Circadian rhythm pathway 0.0017 1 27 22 -0.006 0.058 1000 -1000 -0.044 -1000
E-cadherin signaling events 0.0017 1 5 5 0.025 0.051 1000 -1000 0.006 -1000
Alternative NF-kappaB pathway 0.0017 1 21 13 0 0.07 1000 -1000 0 -1000
Total NA 2821 168776 7203 -7.9 -990 131000 -131000 -4.8 -131000
Signaling mediated by p38-alpha and p38-beta

Figure S1.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S1.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTGS2 -0.092 0.3 -10000 0 -0.68 94 94
MKNK1 0.026 0.004 -10000 0 -10000 0 0
MAPK14 -0.025 0.14 -10000 0 -0.31 102 102
ATF2/c-Jun -0.035 0.13 -10000 0 -0.38 31 31
MAPK11 -0.023 0.14 -10000 0 -0.33 91 91
MITF -0.058 0.17 -10000 0 -0.38 117 117
MAPKAPK5 -0.046 0.16 -10000 0 -0.37 104 104
KRT8 -0.048 0.16 -10000 0 -0.37 105 105
MAPKAPK3 0.026 0.004 -10000 0 -10000 0 0
MAPKAPK2 0.026 0.004 -10000 0 -10000 0 0
p38alpha-beta/CK2 -0.044 0.2 -10000 0 -0.45 106 106
CEBPB -0.026 0.12 0.2 2 -0.37 61 63
SLC9A1 -0.048 0.16 -10000 0 -0.39 100 100
mol:GDP 0 0 -10000 0 -10000 0 0
ATF2 -0.046 0.16 -10000 0 -0.37 104 104
p38alpha-beta/MNK1 -0.019 0.17 -10000 0 -0.38 100 100
JUN -0.037 0.12 -10000 0 -0.39 29 29
PPARGC1A -0.072 0.18 -10000 0 -0.38 137 137
USF1 -0.043 0.16 -10000 0 -0.37 99 99
RAB5/GDP/GDI1 -0.029 0.12 -10000 0 -0.28 108 108
NOS2 -0.12 0.36 -10000 0 -0.84 97 97
DDIT3 -0.047 0.16 -10000 0 -0.37 104 104
RAB5A 0.022 0.044 -10000 0 -0.44 5 5
HSPB1 -0.039 0.14 0.27 17 -0.31 104 121
p38alpha-beta/HBP1 -0.019 0.17 -10000 0 -0.37 99 99
CREB1 -0.053 0.17 -10000 0 -0.4 103 103
RAB5/GDP 0.016 0.031 -10000 0 -0.32 5 5
EIF4E -0.053 0.14 -10000 0 -0.35 93 93
RPS6KA4 -0.047 0.16 -10000 0 -0.37 104 104
PLA2G4A -0.09 0.17 0.22 1 -0.36 135 136
GDI1 -0.046 0.16 -10000 0 -0.37 103 103
TP53 -0.081 0.19 -10000 0 -0.49 96 96
RPS6KA5 -0.048 0.16 -10000 0 -0.38 100 100
ESR1 -0.061 0.18 -10000 0 -0.38 121 121
HBP1 0.026 0.005 -10000 0 -10000 0 0
MEF2C -0.051 0.16 -10000 0 -0.38 108 108
MEF2A -0.047 0.16 -10000 0 -0.38 101 101
EIF4EBP1 -0.053 0.17 -10000 0 -0.41 100 100
KRT19 -0.047 0.16 -10000 0 -0.38 104 104
ELK4 -0.045 0.16 -10000 0 -0.38 100 100
ATF6 -0.043 0.16 -10000 0 -0.37 99 99
ATF1 -0.052 0.17 -10000 0 -0.4 103 103
p38alpha-beta/MAPKAPK2 -0.017 0.17 -10000 0 -0.38 96 96
p38alpha-beta/MAPKAPK3 -0.019 0.17 -10000 0 -0.38 100 100
IL23-mediated signaling events

Figure S2.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S2.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CCL2 -0.32 0.53 -10000 0 -1.2 115 115
IL23A -0.33 0.54 -10000 0 -1.3 111 111
NF kappa B1 p50/RelA/I kappa B alpha -0.32 0.55 -10000 0 -1.2 126 126
positive regulation of T cell mediated cytotoxicity -0.36 0.62 -10000 0 -1.3 133 133
ITGA3 -0.31 0.51 -10000 0 -1.2 105 105
IL17F -0.21 0.33 -10000 0 -0.72 123 123
IL12B -0.005 0.051 -10000 0 -0.14 3 3
STAT1 (dimer) -0.34 0.59 -10000 0 -1.3 135 135
CD4 -0.31 0.52 -10000 0 -1.2 109 109
IL23 -0.32 0.52 -10000 0 -1.2 110 110
IL23R -0.096 0.32 -10000 0 -1.3 37 37
IL1B -0.35 0.56 -10000 0 -1.3 112 112
T-helper cell lineage commitment 0 0 -10000 0 -10000 0 0
IL24 -0.4 0.6 -10000 0 -1.2 164 164
TYK2 -0.004 0.044 -10000 0 -0.47 1 1
STAT4 0.002 0.11 -10000 0 -0.44 31 31
STAT3 0.026 0.004 -10000 0 -10000 0 0
IL18RAP -0.002 0.11 -10000 0 -0.44 33 33
IL12RB1 -0.027 0.12 -10000 0 -0.48 31 31
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
IL12Rbeta1/TYK2 -0.018 0.097 -10000 0 -0.36 32 32
IL23R/JAK2 -0.1 0.32 -10000 0 -1.2 36 36
positive regulation of chronic inflammatory response -0.36 0.62 -10000 0 -1.3 133 133
natural killer cell activation 0.006 0.017 0.08 24 -10000 0 24
JAK2 -0.016 0.089 -10000 0 -0.47 15 15
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
NFKB1 0.02 0.025 -10000 0 -0.45 1 1
RELA 0.021 0.014 -10000 0 -10000 0 0
positive regulation of dendritic cell antigen processing and presentation -0.3 0.48 -10000 0 -1.1 111 111
ALOX12B -0.35 0.55 -10000 0 -1.2 134 134
CXCL1 -0.32 0.53 -10000 0 -1.2 111 111
T cell proliferation -0.36 0.62 -10000 0 -1.3 133 133
NFKBIA 0.02 0.015 -10000 0 -10000 0 0
IL17A -0.18 0.28 -10000 0 -0.59 120 120
PI3K -0.33 0.56 -10000 0 -1.2 129 129
IFNG -0.01 0.049 0.16 17 -0.12 44 61
STAT3 (dimer) -0.31 0.53 -10000 0 -1.2 122 122
IL18R1 0.008 0.088 -10000 0 -0.44 20 20
IL23/IL23R/JAK2/TYK2/SOCS3 -0.18 0.33 -10000 0 -0.76 97 97
IL18/IL18R 0.02 0.11 -10000 0 -0.3 51 51
macrophage activation -0.015 0.021 -10000 0 -0.045 102 102
TNF -0.34 0.55 -10000 0 -1.3 112 112
STAT3/STAT4 -0.33 0.56 -10000 0 -1.2 130 130
STAT4 (dimer) -0.35 0.6 -10000 0 -1.3 133 133
IL18 0.019 0.047 -10000 0 -0.44 5 5
IL19 -0.3 0.5 -10000 0 -1.2 106 106
STAT5A (dimer) -0.34 0.59 -10000 0 -1.3 129 129
STAT1 0.026 0.029 -10000 0 -0.44 2 2
SOCS3 0.024 0.041 -10000 0 -0.44 4 4
CXCL9 -0.36 0.57 -10000 0 -1.3 131 131
MPO -0.33 0.53 -10000 0 -1.2 122 122
positive regulation of humoral immune response -0.36 0.62 -10000 0 -1.3 133 133
IL23/IL23R/JAK2/TYK2 -0.41 0.74 -10000 0 -1.5 130 130
IL6 -0.35 0.57 -10000 0 -1.3 127 127
STAT5A 0.026 0.004 -10000 0 -10000 0 0
IL2 0.008 0.027 -10000 0 -10000 0 0
positive regulation of tyrosine phosphorylation of STAT protein 0.006 0.017 0.08 24 -10000 0 24
CD3E -0.32 0.52 -10000 0 -1.2 110 110
keratinocyte proliferation -0.36 0.62 -10000 0 -1.3 133 133
NOS2 -0.37 0.57 -10000 0 -1.2 143 143
IL4-mediated signaling events

Figure S3.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S3.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.35 0.58 -10000 0 -1.3 120 120
STAT6 (cleaved dimer) -0.43 0.58 -10000 0 -1.3 147 147
IGHG1 -0.11 0.19 -10000 0 -0.39 45 45
IGHG3 -0.4 0.54 -10000 0 -1.2 141 141
AKT1 -0.19 0.32 -10000 0 -0.82 67 67
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 -0.15 0.28 -10000 0 -0.89 40 40
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 -0.2 0.32 -10000 0 -0.88 56 56
THY1 -0.42 0.56 -10000 0 -1.3 133 133
MYB 0.019 0.056 -10000 0 -0.44 8 8
HMGA1 0.023 0.04 -10000 0 -0.44 4 4
IL4/IL4R/JAK1/IL2R gamma/JAK3 -0.24 0.36 -10000 0 -0.81 107 107
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP -0.2 0.33 -10000 0 -0.89 56 56
SP1 0.025 0.032 -10000 0 -0.28 2 2
INPP5D 0.006 0.095 -10000 0 -0.44 24 24
SOCS5 0.024 0.034 -10000 0 -10000 0 0
STAT6 (dimer)/ETS1 -0.42 0.59 -10000 0 -1.3 143 143
SOCS1 -0.27 0.36 -10000 0 -0.77 140 140
SOCS3 -0.21 0.31 -10000 0 -0.83 63 63
FCER2 -0.39 0.56 -10000 0 -1.2 154 154
PARP14 0.024 0.014 -10000 0 -10000 0 0
CCL17 -0.45 0.6 -10000 0 -1.3 144 144
GRB2 0.026 0.004 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP -0.16 0.25 -10000 0 -0.7 47 47
T cell proliferation -0.41 0.58 -10000 0 -1.3 140 140
IL4R/JAK1 -0.42 0.57 -10000 0 -1.3 136 136
EGR2 -0.45 0.6 -10000 0 -1.3 137 137
JAK2 -0.028 0.089 -10000 0 -0.41 18 18
JAK3 0.019 0.056 -10000 0 -0.44 7 7
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
JAK1 0 0.035 -10000 0 -0.45 1 1
COL1A2 -0.14 0.31 -10000 0 -1.4 23 23
CCL26 -0.45 0.6 -10000 0 -1.3 146 146
IL4R -0.44 0.6 -10000 0 -1.3 135 135
PTPN6 0.033 0.016 -10000 0 -10000 0 0
IL13RA2 -0.47 0.63 -10000 0 -1.4 150 150
IL13RA1 -0.019 0.065 -10000 0 -0.45 4 4
IRF4 -0.22 0.5 -10000 0 -1.4 78 78
ARG1 -0.057 0.18 -10000 0 -0.7 16 16
CBL -0.24 0.34 -10000 0 -0.77 106 106
GTF3A 0.017 0.029 -10000 0 -0.16 2 2
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
IL13RA1/JAK2 -0.024 0.093 -10000 0 -0.34 17 17
IRF4/BCL6 -0.19 0.46 -10000 0 -1.3 77 77
CD40LG -0.016 0.13 -10000 0 -0.42 46 46
MAPK14 -0.23 0.34 -10000 0 -0.78 102 102
mitosis -0.18 0.3 -10000 0 -0.76 68 68
STAT6 -0.5 0.72 -10000 0 -1.5 140 140
SPI1 0.018 0.075 -10000 0 -0.44 14 14
RPS6KB1 -0.18 0.29 -10000 0 -0.75 65 65
STAT6 (dimer) -0.5 0.73 -10000 0 -1.5 140 140
STAT6 (dimer)/PARP14 -0.46 0.63 -10000 0 -1.4 139 139
mast cell activation 0.009 0.013 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/DOK2 -0.22 0.34 -10000 0 -0.86 72 72
FRAP1 -0.19 0.32 -10000 0 -0.82 67 67
LTA -0.44 0.6 -10000 0 -1.3 140 140
FES 0.018 0.059 -10000 0 -0.44 9 9
T-helper 1 cell differentiation 0.47 0.66 1.4 141 -10000 0 141
CCL11 -0.45 0.61 -10000 0 -1.4 144 144
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES -0.2 0.32 -10000 0 -0.84 65 65
IL2RG 0.016 0.067 -10000 0 -0.43 11 11
IL10 -0.45 0.61 -10000 0 -1.3 141 141
IRS1 0.019 0.059 -10000 0 -0.44 9 9
IRS2 0.015 0.049 -10000 0 -0.44 6 6
IL4 -0.093 0.2 -10000 0 -1.1 14 14
IL5 -0.42 0.56 -10000 0 -1.2 136 136
IL4/IL4R/JAK1/IL13RA1/JAK2 -0.32 0.44 -10000 0 -0.92 137 137
COL1A1 -0.17 0.38 -10000 0 -1.4 37 37
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
IL4/IL4R/JAK1 -0.43 0.59 -10000 0 -1.3 130 130
IL2R gamma/JAK3 0.024 0.068 -10000 0 -0.32 18 18
TFF3 -0.45 0.6 -10000 0 -1.3 148 148
ALOX15 -0.49 0.64 -10000 0 -1.3 169 169
MYBL1 0.016 0.06 -10000 0 -0.44 9 9
T-helper 2 cell differentiation -0.33 0.46 -10000 0 -0.98 144 144
SHC1 0.026 0.004 -10000 0 -10000 0 0
CEBPB 0.015 0.024 -10000 0 -0.44 1 1
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 -0.18 0.32 -10000 0 -0.88 52 52
mol:PI-3-4-5-P3 -0.19 0.32 -10000 0 -0.82 67 67
PI3K -0.2 0.34 -10000 0 -0.9 66 66
DOK2 0.014 0.057 -10000 0 -0.44 8 8
ETS1 0.022 0.041 -10000 0 -0.41 2 2
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 -0.15 0.24 -10000 0 -0.65 45 45
ITGB3 -0.42 0.57 -10000 0 -1.3 133 133
PIGR -0.56 0.7 -10000 0 -1.4 202 202
IGHE 0.071 0.08 0.18 150 -0.25 1 151
MAPKKK cascade -0.15 0.23 -10000 0 -0.63 46 46
BCL6 0.028 0.008 -10000 0 -10000 0 0
OPRM1 -0.42 0.56 -10000 0 -1.3 131 131
RETNLB -0.54 0.67 -10000 0 -1.4 190 190
SELP -0.47 0.64 -10000 0 -1.4 147 147
AICDA -0.4 0.54 -10000 0 -1.2 132 132
FOXA2 and FOXA3 transcription factor networks

Figure S4.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S4.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ACADVL -0.17 0.33 -10000 0 -0.81 82 82
PCK1 -0.16 0.42 -10000 0 -1.3 59 59
HNF4A -0.16 0.4 0.5 9 -0.99 77 86
KCNJ11 -0.15 0.34 -10000 0 -0.89 56 56
AKT1 -0.11 0.21 -10000 0 -0.47 73 73
response to starvation -0.013 0.049 -10000 0 -0.23 21 21
DLK1 -0.15 0.33 -10000 0 -0.87 56 56
NKX2-1 -0.089 0.31 0.42 4 -1.2 27 31
ACADM -0.18 0.35 -10000 0 -0.8 94 94
TAT -0.095 0.2 -10000 0 -0.75 11 11
CEBPB 0.012 0.027 -10000 0 -0.44 1 1
CEBPA 0.009 0.08 -10000 0 -0.44 16 16
TTR -0.11 0.41 0.55 6 -1.1 67 73
PKLR -0.27 0.45 0.5 1 -0.92 155 156
APOA1 -0.19 0.46 -10000 0 -1.1 70 70
CPT1C -0.18 0.36 0.49 1 -0.84 92 93
ALAS1 -0.07 0.18 -10000 0 -0.57 10 10
TFRC -0.095 0.26 -10000 0 -0.83 26 26
FOXF1 0.024 0.079 0.22 23 -0.44 11 34
NF1 0.027 0.035 -10000 0 -0.44 3 3
HNF1A (dimer) 0.018 0.066 -10000 0 -0.27 22 22
CPT1A -0.17 0.34 -10000 0 -0.8 85 85
HMGCS1 -0.18 0.34 0.49 1 -0.81 84 85
NR3C1 -0.001 0.1 -10000 0 -0.26 63 63
CPT1B -0.19 0.36 -10000 0 -0.81 96 96
chromatin remodeling 0 0 -10000 0 -10000 0 0
SP1 0.019 0.051 -10000 0 -0.19 28 28
GCK -0.17 0.36 0.49 1 -0.83 89 90
CREB1 0.009 0.071 -10000 0 -0.22 36 36
IGFBP1 -0.18 0.39 -10000 0 -1.2 61 61
PDX1 -0.11 0.34 -10000 0 -1.3 33 33
UCP2 -0.18 0.35 -10000 0 -0.81 89 89
ALDOB -0.22 0.43 -10000 0 -0.99 101 101
AFP -0.031 0.11 -10000 0 -0.57 7 7
BDH1 -0.17 0.35 -10000 0 -0.82 84 84
HADH -0.15 0.33 -10000 0 -0.86 57 57
F2 -0.22 0.5 -10000 0 -1.2 88 88
HNF1A 0.018 0.066 -10000 0 -0.27 22 22
G6PC 0.025 0.12 -10000 0 -0.71 5 5
SLC2A2 -0.081 0.22 -10000 0 -0.8 12 12
INS -0.004 0.061 0.2 40 -10000 0 40
FOXA1 -0.021 0.15 0.26 8 -0.44 62 70
FOXA3 0.007 0.1 -10000 0 -0.38 22 22
FOXA2 -0.18 0.37 -10000 0 -0.87 80 80
ABCC8 -0.16 0.35 -10000 0 -0.87 64 64
ALB -0.031 0.11 -10000 0 -0.47 12 12
Endothelins

Figure S5.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S5.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
AKT1 -0.025 0.17 0.25 50 -0.37 77 127
PTK2B 0.019 0.03 -10000 0 -0.45 2 2
mol:Ca2+ -0.025 0.23 0.37 1 -0.78 38 39
EDN1 0.009 0.13 0.22 49 -0.33 44 93
EDN3 -0.03 0.14 -10000 0 -0.44 55 55
EDN2 -0.007 0.13 -10000 0 -0.44 43 43
HRAS/GDP -0.027 0.18 0.34 8 -0.45 51 59
ETA receptor/Endothelin-1/Gq/GTP/PLC beta -0.018 0.16 0.25 6 -0.41 46 52
ADCY4 -0.03 0.15 0.23 6 -0.41 48 54
ADCY5 -0.049 0.17 0.21 16 -0.36 92 108
ADCY6 -0.027 0.15 0.24 5 -0.4 47 52
ADCY7 -0.027 0.15 0.22 7 -0.38 54 61
ADCY1 -0.031 0.15 0.22 7 -0.37 59 66
ADCY2 -0.041 0.17 0.22 8 -0.4 72 80
ADCY3 -0.026 0.15 0.22 8 -0.38 53 61
ADCY8 -0.027 0.14 0.23 5 -0.38 47 52
ADCY9 -0.028 0.15 0.22 7 -0.38 54 61
arachidonic acid secretion -0.05 0.19 0.37 5 -0.48 57 62
ETB receptor/Endothelin-1/Gq/GTP -0.01 0.1 -10000 0 -0.34 35 35
GNAO1 0.018 0.084 -10000 0 -0.44 17 17
HRAS 0.026 0.021 -10000 0 -0.44 1 1
ETA receptor/Endothelin-1/G12/GTP 0.03 0.18 0.36 47 -0.34 74 121
ETA receptor/Endothelin-1/Gs/GTP 0.012 0.17 0.33 34 -0.33 83 117
mol:GTP 0 0.003 -10000 0 -10000 0 0
COL3A1 -0.031 0.2 0.25 53 -0.48 61 114
EDNRB 0.008 0.074 -10000 0 -0.43 14 14
response to oxidative stress 0 0 -10000 0 -10000 0 0
CYSLTR2 -0.039 0.19 0.26 36 -0.54 52 88
CYSLTR1 -0.045 0.22 0.25 52 -0.53 72 124
SLC9A1 -0.007 0.11 0.18 46 -0.28 50 96
mol:GDP -0.038 0.19 0.33 9 -0.48 52 61
SLC9A3 -0.11 0.3 -10000 0 -0.61 122 122
RAF1 -0.038 0.17 0.36 5 -0.43 55 60
JUN -0.015 0.2 -10000 0 -0.68 29 29
JAK2 -0.03 0.18 0.25 51 -0.38 86 137
mol:IP3 -0.015 0.15 0.23 9 -0.42 39 48
ETA receptor/Endothelin-1 0.021 0.22 0.41 51 -0.43 78 129
PLCB1 -0.003 0.1 -10000 0 -0.44 29 29
PLCB2 0.021 0.041 -10000 0 -0.45 4 4
ETA receptor/Endothelin-3 -0.022 0.13 0.23 1 -0.32 75 76
FOS -0.054 0.22 0.41 3 -0.81 33 36
Gai/GDP -0.006 0.19 -10000 0 -0.84 25 25
CRK 0.022 0.011 -10000 0 -10000 0 0
mol:Ca ++ -0.029 0.2 0.28 15 -0.51 59 74
BCAR1 0.025 0.029 -10000 0 -0.44 2 2
PRKCB1 -0.013 0.14 0.23 7 -0.4 41 48
GNAQ 0.02 0.046 -10000 0 -0.44 5 5
GNAZ 0.015 0.071 -10000 0 -0.44 13 13
GNAL 0.015 0.065 -10000 0 -0.44 10 10
Gs family/GDP -0.035 0.17 0.34 5 -0.44 55 60
ETA receptor/Endothelin-1/Gq/GTP -0.01 0.15 0.2 15 -0.42 43 58
MAPK14 -0.017 0.11 0.24 2 -0.38 31 33
TRPC6 -0.03 0.25 0.37 1 -0.85 37 38
GNAI2 0.026 0.004 -10000 0 -10000 0 0
GNAI3 0.026 0.005 -10000 0 -10000 0 0
GNAI1 0.018 0.063 -10000 0 -0.44 10 10
ETB receptor/Endothelin-1/Gq/GTP/PLC beta -0.017 0.12 -10000 0 -0.38 35 35
ETB receptor/Endothelin-2 0.004 0.099 -10000 0 -0.33 42 42
ETB receptor/Endothelin-3 -0.021 0.11 -10000 0 -0.32 64 64
ETB receptor/Endothelin-1 0.013 0.11 0.23 4 -0.31 40 44
MAPK3 -0.047 0.2 0.44 3 -0.64 39 42
MAPK1 -0.054 0.21 0.44 3 -0.66 42 45
Rac1/GDP -0.031 0.17 0.35 4 -0.44 49 53
cAMP biosynthetic process -0.04 0.16 0.26 8 -0.45 52 60
MAPK8 -0.018 0.22 0.35 2 -0.65 43 45
SRC 0.015 0.023 -10000 0 -0.45 1 1
ETB receptor/Endothelin-1/Gi/GTP -0.01 0.1 0.16 9 -0.34 32 41
p130Cas/CRK/Src/PYK2 -0.025 0.21 0.33 17 -0.53 48 65
mol:K + 0 0 -10000 0 -10000 0 0
G12/GDP -0.031 0.17 0.31 6 -0.44 49 55
COL1A2 -0.023 0.22 0.34 15 -0.62 48 63
EntrezGene:2778 0 0 -10000 0 -10000 0 0
ETA receptor/Endothelin-2 -0.002 0.14 0.22 5 -0.3 76 81
mol:DAG -0.014 0.15 0.23 9 -0.42 39 48
MAP2K2 -0.044 0.18 0.38 5 -0.5 46 51
MAP2K1 -0.045 0.18 0.37 4 -0.5 48 52
EDNRA 0.007 0.14 0.22 50 -0.37 40 90
positive regulation of muscle contraction -0.009 0.16 0.22 82 -0.39 49 131
Gq family/GDP -0.023 0.17 0.26 1 -0.48 43 44
HRAS/GTP -0.034 0.17 0.31 9 -0.44 50 59
PRKCH -0.016 0.15 0.22 4 -0.42 40 44
RAC1 0.024 0.008 -10000 0 -10000 0 0
PRKCA -0.012 0.15 0.23 8 -0.42 35 43
PRKCB -0.025 0.17 0.24 5 -0.44 52 57
PRKCE -0.012 0.14 0.24 5 -0.42 36 41
PRKCD -0.014 0.14 0.24 5 -0.42 38 43
PRKCG -0.041 0.16 0.25 5 -0.41 51 56
regulation of vascular smooth muscle contraction -0.065 0.26 0.45 3 -0.96 32 35
PRKCQ -0.029 0.16 0.24 4 -0.43 49 53
PLA2G4A -0.056 0.2 0.38 5 -0.53 57 62
GNA14 0.012 0.077 -10000 0 -0.45 15 15
GNA15 0.014 0.075 -10000 0 -0.45 14 14
GNA12 0.024 0.008 -10000 0 -10000 0 0
GNA11 0.023 0.036 -10000 0 -0.45 3 3
Rac1/GTP 0.029 0.18 0.36 46 -0.34 74 120
MMP1 -0.12 0.3 0.28 6 -0.82 81 87
Wnt signaling

Figure S6.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S6.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Noncanonical Wnts/FZD -0.071 0.16 -9999 0 -0.32 144 144
FZD6 0.019 0.045 -9999 0 -0.44 5 5
WNT6 -0.001 0.13 -9999 0 -0.44 41 41
WNT4 -0.006 0.12 -9999 0 -0.44 41 41
FZD3 0.014 0.053 -9999 0 -0.44 7 7
WNT5A 0.016 0.071 -9999 0 -0.44 13 13
WNT11 -0.034 0.17 -9999 0 -0.44 84 84
Signaling events mediated by the Hedgehog family

Figure S7.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S7.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB2 -0.031 0.16 -10000 0 -0.56 40 40
IHH -0.012 0.14 -10000 0 -0.45 44 44
SHH Np/Cholesterol/GAS1 -0.018 0.11 0.19 2 -0.25 93 95
LRPAP1 0.025 0.02 -10000 0 -0.44 1 1
dorsoventral neural tube patterning 0.018 0.11 0.25 93 -0.18 2 95
SMO/beta Arrestin2 -0.022 0.16 -10000 0 -0.42 59 59
SMO -0.037 0.16 -10000 0 -0.42 66 66
AKT1 -0.026 0.15 -10000 0 -0.43 42 42
ARRB2 0.022 0.01 -10000 0 -10000 0 0
BOC 0.025 0.063 -10000 0 -0.44 9 9
ADRBK1 0.026 0.021 -10000 0 -0.44 1 1
heart looping -0.035 0.16 -10000 0 -0.42 66 66
STIL -0.022 0.12 0.18 28 -0.33 53 81
DHH N/PTCH2 0.009 0.11 -10000 0 -0.34 47 47
DHH N/PTCH1 -0.013 0.13 -10000 0 -0.29 95 95
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
DHH 0.002 0.1 -10000 0 -0.44 28 28
PTHLH -0.055 0.24 -10000 0 -0.83 39 39
determination of left/right symmetry -0.035 0.16 -10000 0 -0.42 66 66
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
skeletal system development -0.054 0.23 -10000 0 -0.81 40 40
IHH N/Hhip -0.023 0.15 -10000 0 -0.36 88 88
DHH N/Hhip -0.012 0.14 -10000 0 -0.34 80 80
mol:Cholesterol 0 0 -10000 0 -10000 0 0
heart development -0.035 0.16 -10000 0 -0.42 66 66
pancreas development -0.021 0.15 -10000 0 -0.44 59 59
HHAT 0.022 0.044 -10000 0 -0.44 5 5
PI3K 0.035 0.031 -10000 0 -0.32 4 4
EntrezGene:84976 0 0 -10000 0 -10000 0 0
GAS1 -0.024 0.16 -10000 0 -0.44 72 72
somite specification -0.035 0.16 -10000 0 -0.42 66 66
SHH Np/Cholesterol/PTCH1 -0.021 0.12 -10000 0 -0.3 81 81
SHH Np/Cholesterol/PTCH2 -0.001 0.079 -10000 0 -0.25 49 49
SHH Np/Cholesterol/Megalin 0.01 0.064 0.19 2 -0.25 29 31
SHH -0.026 0.067 0.23 1 -0.32 27 28
catabolic process -0.018 0.12 -10000 0 -0.32 73 73
SMO/Vitamin D3 -0.03 0.15 -10000 0 -0.38 69 69
SHH Np/Cholesterol/Hhip -0.016 0.1 0.19 2 -0.27 78 80
LRP2 0.011 0.033 -10000 0 -10000 0 0
receptor-mediated endocytosis -0.034 0.14 -10000 0 -0.4 56 56
SHH Np/Cholesterol/BOC 0.009 0.071 0.19 2 -0.25 35 37
SHH Np/Cholesterol/CDO 0.007 0.066 -10000 0 -0.25 32 32
mesenchymal cell differentiation 0.016 0.1 0.26 78 -0.18 2 80
mol:Vitamin D3 -0.013 0.13 0.2 31 -0.31 72 103
IHH N/PTCH2 -0.001 0.12 -10000 0 -0.34 56 56
CDON 0.023 0.045 -10000 0 -0.44 5 5
IHH N/PTCH1 -0.007 0.13 -10000 0 -0.32 73 73
Megalin/LRPAP1 0.039 0.023 -10000 0 -0.32 1 1
PTCH2 0.008 0.094 -10000 0 -0.44 23 23
SHH Np/Cholesterol 0 0.057 -10000 0 -0.24 29 29
PTCH1 -0.018 0.12 -10000 0 -0.32 73 73
HHIP -0.021 0.15 -10000 0 -0.44 59 59
TCR signaling in naïve CD8+ T cells

Figure S8.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S8.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GRB2/SOS1/SHC -0.037 0.2 0.27 6 -0.52 65 71
FYN -0.072 0.25 0.27 2 -0.65 69 71
LAT/GRAP2/SLP76 -0.048 0.21 -10000 0 -0.54 72 72
IKBKB 0.023 0.009 -10000 0 -10000 0 0
AKT1 -0.055 0.17 0.21 2 -0.43 80 82
B2M 0.023 0.013 -10000 0 -10000 0 0
IKBKG -0.017 0.055 0.1 10 -0.14 55 65
MAP3K8 0.026 0.02 -10000 0 -0.44 1 1
mol:Ca2+ -0.018 0.023 0.088 7 -0.077 17 24
integrin-mediated signaling pathway 0.029 0.038 -10000 0 -0.26 9 9
LAT/GRAP2/SLP76/VAV1/PI3K Class IA -0.083 0.25 0.28 1 -0.62 81 82
TRPV6 0.018 0.25 1.1 24 -0.44 13 37
CD28 -0.001 0.11 -10000 0 -0.45 34 34
SHC1 -0.072 0.24 0.28 6 -0.64 68 74
receptor internalization -0.076 0.26 -10000 0 -0.69 71 71
PRF1 -0.079 0.3 -10000 0 -0.92 54 54
KRAS 0.022 0.044 -10000 0 -0.44 5 5
GRB2 0.026 0.004 -10000 0 -10000 0 0
COT/AKT1 -0.034 0.14 0.2 2 -0.34 78 80
LAT -0.076 0.24 -10000 0 -0.64 71 71
EntrezGene:6955 -0.001 0.003 -10000 0 -10000 0 0
CD3D 0.003 0.1 -10000 0 -0.45 28 28
CD3E 0.008 0.094 -10000 0 -0.46 22 22
CD3G -0.012 0.13 -10000 0 -0.45 46 46
RASGRP2 -0.008 0.048 -10000 0 -0.18 38 38
RASGRP1 -0.042 0.18 0.26 3 -0.46 74 77
HLA-A 0.02 0.047 -10000 0 -0.45 5 5
RASSF5 0.02 0.056 -10000 0 -0.44 8 8
RAP1A/GTP/RAPL 0.03 0.039 -10000 0 -0.26 9 9
mol:GTP 0 0 -10000 0 -10000 0 0
mol:GDP 0.006 0.064 0.14 15 -0.13 61 76
PDK1/CARD11/BCL10/MALT1/TRAF6 -0.036 0.084 -10000 0 -0.22 73 73
PRKCA -0.001 0.11 0.15 36 -0.26 60 96
GRAP2 0.009 0.09 -10000 0 -0.44 21 21
mol:IP3 -0.039 0.15 0.2 9 -0.42 63 72
EntrezGene:6957 -0.001 0.004 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8 -0.065 0.24 -10000 0 -0.66 61 61
ORAI1 -0.027 0.2 -10000 0 -0.96 24 24
CSK -0.073 0.24 0.25 1 -0.65 68 69
B7 family/CD28 -0.06 0.28 -10000 0 -0.69 78 78
CHUK 0.023 0.035 -10000 0 -0.44 3 3
TCR/CD3/MHC I/CD8/LCK/ZAP-70 -0.085 0.29 -10000 0 -0.76 69 69
PTPN6 -0.075 0.24 0.27 1 -0.66 67 68
VAV1 -0.082 0.26 0.27 2 -0.66 74 76
Monovalent TCR/CD3 -0.038 0.19 -10000 0 -0.49 62 62
CBL 0.026 0.004 -10000 0 -10000 0 0
LCK -0.077 0.26 0.24 2 -0.66 73 75
PAG1 -0.063 0.25 0.29 1 -0.64 68 69
RAP1A 0.025 0.02 -10000 0 -0.44 1 1
TCR/CD3/MHC I/CD8/LCK -0.084 0.28 -10000 0 -0.74 70 70
CD80 -0.009 0.12 -10000 0 -0.45 42 42
CD86 0.002 0.11 -10000 0 -0.45 32 32
PDK1/CARD11/BCL10/MALT1 -0.034 0.1 0.13 2 -0.27 75 77
HRAS 0.026 0.021 -10000 0 -0.44 1 1
GO:0035030 -0.076 0.21 -10000 0 -0.55 79 79
CD8A -0.007 0.13 -10000 0 -0.45 43 43
CD8B -0.009 0.13 -10000 0 -0.45 42 42
PTPRC -0.004 0.12 -10000 0 -0.45 37 37
PDK1/PKC theta -0.063 0.2 0.24 4 -0.52 77 81
CSK/PAG1 -0.06 0.24 0.27 3 -0.63 66 69
SOS1 0.027 0.002 -10000 0 -10000 0 0
peptide-MHC class I 0.031 0.039 -10000 0 -0.33 5 5
GRAP2/SLP76 -0.053 0.25 -10000 0 -0.64 71 71
STIM1 0.003 0.11 1.2 4 -0.94 1 5
RAS family/GTP 0.002 0.081 0.16 9 -0.19 49 58
TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin -0.084 0.29 -10000 0 -0.75 71 71
mol:DAG -0.048 0.13 -10000 0 -0.38 63 63
RAP1A/GDP 0.005 0.031 0.079 10 -0.065 36 46
PLCG1 0.015 0.023 -10000 0 -0.44 1 1
CD247 0.01 0.087 -10000 0 -0.45 19 19
cytotoxic T cell degranulation -0.074 0.28 -10000 0 -0.85 55 55
RAP1A/GTP -0.003 0.019 -10000 0 -0.068 38 38
mol:PI-3-4-5-P3 -0.064 0.2 0.23 2 -0.5 81 83
LAT/GRAP2/SLP76/VAV1/PLCgamma1 -0.051 0.2 0.22 5 -0.56 62 67
NRAS 0.018 0.059 -10000 0 -0.44 9 9
ZAP70 0.003 0.11 -10000 0 -0.45 31 31
GRB2/SOS1 0.039 0.007 -10000 0 -10000 0 0
LAT/GRAP2/SLP76/VAV1 -0.056 0.21 -10000 0 -0.54 75 75
MALT1 0.018 0.03 -10000 0 -0.44 2 2
TRAF6 0.025 0.02 -10000 0 -0.44 1 1
CD8 heterodimer -0.009 0.15 -10000 0 -0.39 68 68
CARD11 0.007 0.12 -10000 0 -0.44 35 35
PRKCB -0.007 0.13 0.15 40 -0.3 65 105
PRKCE 0 0.12 0.15 38 -0.27 60 98
PRKCQ -0.072 0.24 0.27 2 -0.59 79 81
LCP2 0.013 0.081 -10000 0 -0.44 17 17
BCL10 0.023 0.04 -10000 0 -0.44 4 4
regulation of survival gene product expression -0.045 0.14 0.2 2 -0.36 79 81
IKK complex 0.017 0.068 0.1 136 -0.12 43 179
RAS family/GDP -0.005 0.016 -10000 0 -0.07 12 12
MAP3K14 -0.029 0.1 0.17 2 -0.26 75 77
PDPK1 -0.051 0.16 0.2 4 -0.4 78 82
TCR/CD3/MHC I/CD8/Fyn -0.085 0.3 -10000 0 -0.72 78 78
Osteopontin-mediated events

Figure S9.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S9.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IKK alpha homodimer -0.031 0.11 -10000 0 -0.26 93 93
NF kappa B1 p50/RelA/I kappa B alpha -0.029 0.12 0.31 3 -0.38 22 25
alphaV/beta3 Integrin/Osteopontin/Src -0.009 0.14 -10000 0 -0.32 93 93
AP1 -0.024 0.15 -10000 0 -0.43 37 37
ILK -0.041 0.11 -10000 0 -0.26 94 94
bone resorption -0.042 0.11 0.18 6 -0.4 18 24
PTK2B 0.019 0.03 -10000 0 -0.44 2 2
PYK2/p130Cas 0.012 0.13 -10000 0 -0.25 90 90
ITGAV 0.019 0.065 -10000 0 -0.44 11 11
mol:GTP 0 0 -10000 0 -10000 0 0
CD44/Rho Family GTPase/ROCK2 0.03 0.06 -10000 0 -0.34 14 14
alphaV/beta3 Integrin/Osteopontin 0.008 0.14 -10000 0 -0.29 94 94
MAP3K1 -0.044 0.12 0.19 5 -0.28 95 100
JUN 0.022 0.04 -10000 0 -0.45 4 4
MAPK3 -0.056 0.097 0.19 2 -0.26 92 94
MAPK1 -0.055 0.096 0.19 2 -0.26 91 93
Rac1/GDP 0.018 0.006 -10000 0 -10000 0 0
NFKB1 0.025 0.02 -10000 0 -0.44 1 1
MAPK8 -0.059 0.1 0.18 5 -0.27 94 99
ITGB3 0.019 0.066 -10000 0 -0.45 11 11
NFKBIA -0.046 0.11 0.18 2 -0.35 32 34
FOS 0.012 0.082 -10000 0 -0.44 17 17
CD44 0.023 0.04 -10000 0 -0.44 4 4
CHUK 0.023 0.035 -10000 0 -0.44 3 3
PLAU -0.046 0.14 -10000 0 -1.1 5 5
NF kappa B1 p50/RelA -0.017 0.12 -10000 0 -0.45 14 14
BCAR1 0.025 0.029 -10000 0 -0.44 2 2
RELA 0.026 0.004 -10000 0 -10000 0 0
alphaV beta3 Integrin 0.028 0.072 -10000 0 -0.33 21 21
mol:GDP 0 0 -10000 0 -10000 0 0
SYK -0.042 0.11 0.18 5 -0.27 93 98
VAV3 -0.083 0.12 0.18 4 -0.26 155 159
MAP3K14 -0.042 0.11 0.19 2 -0.27 95 97
ROCK2 0.017 0.065 -10000 0 -0.44 11 11
SPP1 -0.029 0.17 -10000 0 -0.44 83 83
RAC1 0.024 0.008 -10000 0 -10000 0 0
Rac1/GTP -0.06 0.12 0.17 3 -0.24 142 145
MMP2 -0.074 0.13 -10000 0 -0.47 38 38
Noncanonical Wnt signaling pathway

Figure S10.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S10.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC2 -0.015 0.11 -10000 0 -0.44 36 36
GNB1/GNG2 -0.061 0.16 -10000 0 -0.42 58 58
mol:DAG -0.062 0.13 -10000 0 -0.4 47 47
PLCG1 -0.064 0.14 -10000 0 -0.42 47 47
YES1 -0.074 0.15 0.19 1 -0.3 137 138
FZD3 0.014 0.053 -10000 0 -0.44 7 7
FZD6 0.019 0.045 -10000 0 -0.44 5 5
G protein -0.012 0.18 0.26 23 -0.42 47 70
MAP3K7 -0.065 0.11 -10000 0 -0.37 43 43
mol:Ca2+ -0.06 0.13 -10000 0 -0.39 47 47
mol:IP3 -0.062 0.13 -10000 0 -0.4 47 47
NLK -0.007 0.096 -10000 0 -0.75 9 9
GNB1 0.025 0.006 -10000 0 -10000 0 0
CAMK2A -0.065 0.12 -10000 0 -0.38 47 47
MAP3K7IP1 0 0 -10000 0 -10000 0 0
Noncanonical Wnts/FZD -0.071 0.16 -10000 0 -0.32 144 144
CSNK1A1 0.024 0.028 -10000 0 -0.44 2 2
GNAS -0.055 0.15 0.19 25 -0.44 48 73
GO:0007205 -0.064 0.13 -10000 0 -0.4 48 48
WNT6 -0.001 0.13 -10000 0 -0.44 41 41
WNT4 -0.006 0.12 -10000 0 -0.44 41 41
NFAT1/CK1 alpha -0.07 0.16 -10000 0 -0.44 67 67
GNG2 0.021 0.045 -10000 0 -0.44 5 5
WNT5A 0.016 0.071 -10000 0 -0.44 13 13
WNT11 -0.034 0.17 -10000 0 -0.44 84 84
CDC42 -0.071 0.15 0.18 1 -0.42 55 56
HIF-1-alpha transcription factor network

Figure S11.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S11.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PKM2 -0.11 0.31 -10000 0 -0.76 60 60
HDAC7 0.026 0.02 -10000 0 -0.44 1 1
HIF1A/ARNT/Cbp/p300/Src-1 -0.061 0.32 -10000 0 -0.76 53 53
SMAD4 0.019 0.013 -10000 0 -10000 0 0
ID2 -0.11 0.31 -10000 0 -0.77 58 58
AP1 0.024 0.07 -10000 0 -0.32 21 21
ABCG2 -0.12 0.32 -10000 0 -0.76 72 72
HIF1A -0.012 0.086 -10000 0 -0.52 6 6
TFF3 -0.12 0.32 -10000 0 -0.78 69 69
GATA2 0.01 0.086 -10000 0 -0.44 19 19
AKT1 -0.009 0.08 -10000 0 -0.24 14 14
response to hypoxia -0.02 0.063 -10000 0 -0.19 21 21
MCL1 -0.12 0.31 -10000 0 -0.76 60 60
NDRG1 -0.11 0.29 -10000 0 -0.75 57 57
SERPINE1 -0.11 0.32 -10000 0 -0.75 68 68
FECH -0.12 0.3 -10000 0 -0.75 63 63
FURIN -0.11 0.31 -10000 0 -0.76 61 61
NCOA2 0.019 0.049 -10000 0 -0.44 6 6
EP300 -0.012 0.1 -10000 0 -0.3 34 34
HMOX1 -0.12 0.31 -10000 0 -0.76 65 65
BHLHE40 -0.11 0.31 -10000 0 -0.75 64 64
BHLHE41 -0.12 0.33 -10000 0 -0.82 61 61
HIF1A/ARNT/SMAD3/SMAD4/SP1 0.002 0.12 -10000 0 -0.4 9 9
ENG -0.024 0.096 0.38 2 -0.4 8 10
JUN 0.022 0.041 -10000 0 -0.44 4 4
RORA -0.12 0.32 -10000 0 -0.76 69 69
ABCB1 -0.14 0.36 -10000 0 -0.98 82 82
TFRC -0.11 0.31 -10000 0 -0.75 66 66
CXCR4 -0.12 0.32 -10000 0 -0.77 64 64
TF -0.12 0.33 -10000 0 -0.77 70 70
CITED2 -0.11 0.31 -10000 0 -0.75 63 63
HIF1A/ARNT -0.065 0.4 -10000 0 -0.9 50 50
LDHA 0.011 0.1 -10000 0 -0.89 4 4
ETS1 -0.11 0.31 -10000 0 -0.76 61 61
PGK1 -0.11 0.31 -10000 0 -0.75 63 63
NOS2 -0.14 0.34 -10000 0 -0.77 78 78
ITGB2 -0.12 0.32 -10000 0 -0.77 68 68
ALDOA -0.11 0.31 -10000 0 -0.75 63 63
Cbp/p300/CITED2 -0.11 0.34 -10000 0 -0.86 56 56
FOS 0.012 0.082 -10000 0 -0.44 17 17
HK2 -0.11 0.31 -10000 0 -0.76 62 62
SP1 0.008 0.057 -10000 0 -0.14 54 54
GCK -0.025 0.25 -10000 0 -1.2 18 18
HK1 -0.11 0.31 -10000 0 -0.74 65 65
NPM1 -0.12 0.31 -10000 0 -0.76 64 64
EGLN1 -0.11 0.31 -10000 0 -0.75 63 63
CREB1 0.029 0.028 -10000 0 -0.44 2 2
PGM1 -0.11 0.31 -10000 0 -0.75 63 63
SMAD3 0.023 0.035 -10000 0 -0.44 3 3
EDN1 -0.063 0.25 -10000 0 -0.96 30 30
IGFBP1 -0.13 0.33 -10000 0 -0.75 79 79
VEGFA -0.076 0.26 0.4 1 -0.67 46 47
HIF1A/JAB1 0.007 0.064 -10000 0 -0.34 5 5
CP -0.14 0.34 -10000 0 -0.78 84 84
CXCL12 -0.12 0.31 -10000 0 -0.75 69 69
COPS5 0.023 0.009 -10000 0 -10000 0 0
SMAD3/SMAD4 0.027 0.031 -10000 0 -0.3 3 3
BNIP3 -0.12 0.32 -10000 0 -0.76 71 71
EGLN3 -0.11 0.31 -10000 0 -0.77 62 62
CA9 -0.15 0.35 -10000 0 -0.74 100 100
TERT -0.12 0.32 -10000 0 -0.77 68 68
ENO1 -0.11 0.31 -10000 0 -0.76 61 61
PFKL -0.12 0.31 -10000 0 -0.75 63 63
NCOA1 0.026 0.02 -10000 0 -0.44 1 1
ADM -0.11 0.31 -10000 0 -0.77 59 59
ARNT -0.01 0.073 -10000 0 -0.5 1 1
HNF4A 0.007 0.055 -10000 0 -0.4 8 8
ADFP -0.12 0.3 -10000 0 -0.74 65 65
SLC2A1 -0.077 0.26 0.4 1 -0.67 47 48
LEP -0.11 0.31 -10000 0 -0.73 66 66
HIF1A/ARNT/Cbp/p300 -0.07 0.33 -10000 0 -0.77 54 54
EPO -0.052 0.23 -10000 0 -0.8 18 18
CREBBP -0.011 0.099 -10000 0 -0.3 33 33
HIF1A/ARNT/Cbp/p300/HDAC7 -0.058 0.32 -10000 0 -0.78 47 47
PFKFB3 -0.11 0.31 -10000 0 -0.75 63 63
NT5E -0.12 0.32 -10000 0 -0.78 66 66
Fc-epsilon receptor I signaling in mast cells

Figure S12.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S12.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PPAP2A 0.025 0.02 -10000 0 -0.44 1 1
LAT2 -0.043 0.13 -10000 0 -0.36 61 61
AP1 -0.051 0.21 -10000 0 -0.57 59 59
mol:PIP3 -0.063 0.18 0.29 10 -0.46 70 80
IKBKB -0.02 0.12 0.21 39 -0.29 51 90
AKT1 -0.068 0.11 0.34 10 -0.35 36 46
IKBKG -0.032 0.11 0.22 15 -0.29 55 70
MS4A2 -0.024 0.14 -10000 0 -0.44 56 56
mol:Sphingosine-1-phosphate 0 0 -10000 0 -10000 0 0
PIK3CA 0.024 0.028 -10000 0 -0.45 2 2
MAP3K1 -0.058 0.16 0.25 8 -0.44 58 66
mol:Ca2+ -0.046 0.14 0.26 11 -0.37 56 67
LYN 0.019 0.015 -10000 0 -10000 0 0
CBLB -0.044 0.13 -10000 0 -0.35 64 64
SHC1 0.026 0.004 -10000 0 -10000 0 0
RasGAP/p62DOK 0.048 0.031 -10000 0 -0.25 5 5
positive regulation of cell migration 0 0 -10000 0 -10000 0 0
INPP5D 0.006 0.095 -10000 0 -0.44 24 24
PLD2 -0.061 0.12 0.32 12 -0.27 96 108
PTPN13 -0.064 0.17 0.32 1 -0.55 39 40
PTPN11 0.014 0.05 -10000 0 -0.46 5 5
GO:0007205 0 0 -10000 0 -10000 0 0
regulation of mast cell degranulation -0.047 0.11 0.36 5 -0.33 34 39
SYK 0.022 0.015 -10000 0 -10000 0 0
GRB2 0.026 0.004 -10000 0 -10000 0 0
LAT/PLCgamma1/GRB2/SLP76/GADs -0.035 0.19 0.2 1 -0.46 73 74
LAT -0.046 0.13 -10000 0 -0.35 68 68
PAK2 -0.06 0.17 0.27 8 -0.49 57 65
NFATC2 -0.044 0.14 -10000 0 -0.55 39 39
HRAS -0.063 0.19 0.29 5 -0.53 58 63
GAB2 0.025 0.028 -10000 0 -0.44 2 2
PLA2G1B 0.012 0.11 -10000 0 -0.84 9 9
Fc epsilon R1 -0.015 0.16 0.2 1 -0.32 106 107
Antigen/IgE/Fc epsilon R1 -0.013 0.14 0.18 1 -0.29 106 107
mol:GDP -0.069 0.2 0.23 2 -0.6 57 59
JUN 0.023 0.04 -10000 0 -0.44 4 4
mol:Ca++ 0 0 -10000 0 -10000 0 0
PIK3R1 0.024 0.029 -10000 0 -0.45 2 2
FOS 0.013 0.082 -10000 0 -0.44 17 17
Antigen/IgE/Fc epsilon R1/LYN/SYK -0.039 0.14 -10000 0 -0.34 70 70
CHUK -0.034 0.11 0.22 12 -0.3 54 66
KLRG1 -0.043 0.12 -10000 0 -0.26 110 110
VAV1 -0.057 0.15 -10000 0 -0.37 76 76
calcium-dependent protein kinase C activity 0 0 -10000 0 -10000 0 0
CBL -0.042 0.13 -10000 0 -0.34 63 63
negative regulation of mast cell degranulation -0.036 0.13 0.22 2 -0.33 59 61
BTK -0.066 0.22 -10000 0 -0.68 52 52
Fc epsilon R1/FcgammaRIIB/SHIP/RasGAP/p62DOK -0.073 0.19 -10000 0 -0.37 129 129
GAB2/PI3K/SHP2 -0.079 0.1 -10000 0 -0.29 81 81
Antigen/IgE/Fc epsilon R1/LYN/SYK/WIP -0.038 0.12 -10000 0 -0.27 100 100
RAF1 0.016 0.12 -10000 0 -0.93 9 9
Fc epsilon R1/FcgammaRIIB/SHIP -0.022 0.2 0.25 1 -0.34 142 143
FCER1G 0.01 0.083 -10000 0 -0.45 17 17
FCER1A -0.03 0.15 -10000 0 -0.46 61 61
Antigen/IgE/Fc epsilon R1/Fyn -0.002 0.14 -10000 0 -0.28 107 107
MAPK3 0.013 0.11 -10000 0 -0.84 9 9
MAPK1 0.008 0.12 -10000 0 -0.88 9 9
NFKB1 0.025 0.02 -10000 0 -0.44 1 1
MAPK8 -0.079 0.24 -10000 0 -0.61 69 69
DUSP1 0.026 0.037 -10000 0 -0.44 3 3
NF-kappa-B/RelA -0.011 0.07 0.12 3 -0.18 47 50
actin cytoskeleton reorganization -0.037 0.16 0.33 1 -0.54 33 34
mol:Glucocorticoid Dexamethasone 0 0 -10000 0 -10000 0 0
PI3K -0.044 0.17 0.28 2 -0.46 59 61
FER -0.044 0.13 -10000 0 -0.35 64 64
RELA 0.026 0.004 -10000 0 -10000 0 0
ITK -0.029 0.11 -10000 0 -0.4 39 39
SOS1 0.027 0.002 -10000 0 -10000 0 0
PLCG1 -0.017 0.21 0.27 15 -0.54 55 70
cytokine secretion -0.012 0.047 -10000 0 -0.15 19 19
SPHK1 -0.049 0.14 -10000 0 -0.37 68 68
PTK2 -0.04 0.17 -10000 0 -0.58 30 30
NTAL/PLCgamma1/GRB2/SLP76/GADs -0.03 0.2 0.21 9 -0.48 71 80
EDG1 0 0 -10000 0 -10000 0 0
mol:DAG -0.056 0.17 0.28 10 -0.48 58 68
MAP2K2 0.009 0.11 -10000 0 -0.85 9 9
MAP2K1 0.007 0.11 -10000 0 -0.86 9 9
MAP2K7 0.025 0.02 -10000 0 -0.44 1 1
KLRG1/SHP2 -0.029 0.12 0.21 4 -0.26 85 89
MAP2K4 -0.14 0.36 -10000 0 -0.88 108 108
Fc epsilon R1/FcgammaRIIB -0.021 0.19 0.22 5 -0.36 124 129
mol:Choline -0.06 0.12 0.32 12 -0.27 96 108
SHC/Grb2/SOS1 -0.004 0.14 -10000 0 -0.36 53 53
FYN 0.023 0.04 -10000 0 -0.44 4 4
DOK1 0.027 0.001 -10000 0 -10000 0 0
PXN -0.038 0.16 0.44 2 -0.56 25 27
HCLS1 -0.045 0.13 -10000 0 -0.35 65 65
PRKCB -0.047 0.15 0.25 12 -0.4 59 71
FCGR2B -0.017 0.14 -10000 0 -0.44 57 57
IGHE -0.003 0.006 -10000 0 -10000 0 0
KLRG1/SHIP -0.037 0.13 0.23 2 -0.34 59 61
LCP2 0.013 0.082 -10000 0 -0.45 17 17
PLA2G4A -0.073 0.16 0.17 2 -0.34 111 113
RASA1 0.024 0.028 -10000 0 -0.44 2 2
mol:Phosphatidic acid -0.06 0.12 0.32 12 -0.27 96 108
IKK complex -0.014 0.098 0.2 33 -0.23 42 75
WIPF1 0.02 0.059 -10000 0 -0.44 9 9
Ephrin B reverse signaling

Figure S13.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S13.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EFNB2 0.02 0.023 -10000 0 -0.44 1 1
EPHB2 0.019 0.06 -10000 0 -0.45 9 9
EFNB1 -0.003 0.04 0.23 2 -0.32 6 8
mol:GTP 0 0 -10000 0 -10000 0 0
Rac1/GDP 0.027 0.11 -10000 0 -0.25 62 62
Ephrin B2/EPHB1-2 0.021 0.083 0.17 1 -0.25 42 43
neuron projection morphogenesis 0.01 0.096 -10000 0 -0.24 62 62
Ephrin B1/EPHB1-2/Tiam1 0.025 0.11 0.22 1 -0.26 67 68
DNM1 0.024 0.046 -10000 0 -0.44 5 5
cell-cell signaling 0.001 0.004 -10000 0 -10000 0 0
MAP2K4 -0.061 0.17 0.24 1 -0.49 72 73
YES1 -0.09 0.26 -10000 0 -0.72 77 77
Ephrin B1/EPHB1-2/NCK2 0.038 0.095 0.2 2 -0.25 47 49
PI3K -0.032 0.19 -10000 0 -0.47 84 84
mol:GDP 0.023 0.11 0.21 1 -0.26 67 68
ITGA2B 0.007 0.098 -10000 0 -0.44 24 24
endothelial cell proliferation 0.027 0.02 -10000 0 -0.27 1 1
FYN -0.091 0.26 -10000 0 -0.7 82 82
MAP3K7 -0.067 0.18 -10000 0 -0.51 75 75
FGR -0.095 0.26 -10000 0 -0.71 80 80
TIAM1 0.008 0.1 -10000 0 -0.44 26 26
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
RGS3 0.026 0.003 -10000 0 -10000 0 0
cell adhesion -0.055 0.18 -10000 0 -0.48 76 76
LYN -0.086 0.25 -10000 0 -0.7 80 80
Ephrin B1/EPHB1-2/Src Family Kinases -0.082 0.22 -10000 0 -0.63 78 78
Ephrin B1/EPHB1-2 -0.067 0.19 -10000 0 -0.57 69 69
SRC -0.079 0.24 -10000 0 -0.69 73 73
ITGB3 0.018 0.066 -10000 0 -0.44 11 11
EPHB1 0.007 0.12 -10000 0 -0.44 36 36
EPHB4 0.025 0.006 -10000 0 -10000 0 0
RAC1 0.024 0.008 -10000 0 -10000 0 0
Ephrin B2/EPHB4 0.027 0.02 -10000 0 -0.27 1 1
alphaIIb/beta3 Integrin 0.02 0.089 -10000 0 -0.32 35 35
BLK -0.098 0.26 -10000 0 -0.74 75 75
HCK -0.083 0.24 -10000 0 -0.7 72 72
regulation of stress fiber formation -0.037 0.093 0.25 47 -0.2 2 49
MAPK8 -0.062 0.16 -10000 0 -0.46 76 76
Ephrin B1/EPHB1-2/RGS3 0.038 0.092 -10000 0 -0.25 47 47
endothelial cell migration -0.019 0.16 0.24 46 -0.44 59 105
NCK2 0.026 0.02 -10000 0 -0.44 1 1
PTPN13 -0.046 0.19 -10000 0 -0.54 71 71
regulation of focal adhesion formation -0.037 0.093 0.25 47 -0.2 2 49
chemotaxis -0.036 0.091 0.24 47 -10000 0 47
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
Rac1/GTP 0.019 0.1 -10000 0 -0.25 62 62
angiogenesis -0.068 0.19 -10000 0 -0.56 71 71
LCK -0.093 0.26 -10000 0 -0.71 81 81
Reelin signaling pathway

Figure S14.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S14.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDK5R1/CDK5 0.037 0.011 -10000 0 -10000 0 0
VLDLR -0.001 0.11 -10000 0 -0.44 34 34
CRKL 0.026 0.005 -10000 0 -10000 0 0
LRPAP1 0.025 0.02 -10000 0 -0.44 1 1
FYN 0.023 0.04 -10000 0 -0.44 4 4
ITGA3 0.025 0.029 -10000 0 -0.44 2 2
RELN/VLDLR/Fyn 0.004 0.13 -10000 0 -0.3 79 79
MAPK8IP1/MKK7/MAP3K11/JNK1 0.067 0.057 -10000 0 -0.27 12 12
AKT1 -0.041 0.11 -10000 0 -0.26 104 104
MAP2K7 0.025 0.02 -10000 0 -0.44 1 1
RAPGEF1 0.026 0.02 -10000 0 -0.44 1 1
DAB1 -0.009 0.12 -10000 0 -0.44 41 41
RELN/LRP8/DAB1 0.004 0.12 -10000 0 -0.26 89 89
LRPAP1/LRP8 0.035 0.031 -10000 0 -0.32 4 4
RELN/LRP8/DAB1/Fyn 0.011 0.12 -10000 0 -0.25 93 93
DAB1/alpha3/beta1 Integrin -0.005 0.13 -10000 0 -0.26 109 109
long-term memory -0.01 0.14 -10000 0 -0.26 130 130
DAB1/LIS1 -0.001 0.14 -10000 0 -0.26 109 109
DAB1/CRLK/C3G -0.006 0.14 -10000 0 -0.26 109 109
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
DAB1/NCK2 0.008 0.14 -10000 0 -0.27 110 110
ARHGEF2 0.026 0.004 -10000 0 -10000 0 0
mol:Src family inhibitors PP1 and PP2 0 0 -10000 0 -10000 0 0
GRIN2A 0.013 0.051 -10000 0 -0.44 5 5
CDK5R1 0.026 0.007 -10000 0 -10000 0 0
RELN -0.014 0.14 -10000 0 -0.44 52 52
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
RELN/LRP8/Fyn 0.019 0.1 -10000 0 -0.27 59 59
GRIN2A/RELN/LRP8/DAB1/Fyn 0.02 0.13 -10000 0 -0.26 98 98
MAPK8 0.025 0.02 -10000 0 -0.44 1 1
RELN/VLDLR/DAB1 -0.011 0.14 -10000 0 -0.28 108 108
ITGB1 0.027 0.002 -10000 0 -10000 0 0
MAP1B -0.065 0.12 0.16 16 -0.28 114 130
RELN/LRP8 0.021 0.099 -10000 0 -0.27 56 56
GRIN2B/RELN/LRP8/DAB1/Fyn 0 0.15 -10000 0 -0.27 125 125
PI3K 0.035 0.031 -10000 0 -0.32 4 4
mol:PP2 0 0 -10000 0 -10000 0 0
alpha3/beta1 Integrin 0.037 0.023 -10000 0 -0.32 2 2
RAP1A -0.064 0.11 0.32 5 -0.35 28 33
PAFAH1B1 0.022 0.01 -10000 0 -10000 0 0
MAPK8IP1 0.018 0.066 -10000 0 -0.44 11 11
CRLK/C3G 0.037 0.018 -10000 0 -0.32 1 1
GRIN2B -0.01 0.12 -10000 0 -0.44 43 43
NCK2 0.026 0.02 -10000 0 -0.44 1 1
neuron differentiation -0.019 0.1 0.16 1 -0.37 20 21
neuron adhesion -0.064 0.11 0.34 7 -0.42 16 23
LRP8 0.023 0.035 -10000 0 -0.44 3 3
GSK3B -0.047 0.11 -10000 0 -0.25 104 104
RELN/VLDLR/DAB1/Fyn -0.004 0.14 -10000 0 -0.27 112 112
MAP3K11 0.025 0.02 -10000 0 -0.44 1 1
RELN/VLDLR/DAB1/P13K -0.038 0.12 -10000 0 -0.27 111 111
CDK5 0.026 0.005 -10000 0 -10000 0 0
MAPT -0.022 0.13 0.77 8 -0.4 32 40
neuron migration -0.057 0.13 0.24 11 -0.32 82 93
RELN/LRP8/DAB1/Fyn/MAPK8IP1/MKK7/MAP3K11/JNK1 -0.018 0.1 -10000 0 -0.38 19 19
RELN/VLDLR 0.017 0.12 -10000 0 -0.28 79 79
TCGA08_p53

Figure S15.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S15.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDKN2A -0.031 0.077 -10000 0 -0.32 37 37
TP53 -0.032 0.094 0.19 2 -0.26 71 73
Senescence -0.032 0.094 0.19 2 -0.26 71 73
Apoptosis -0.032 0.094 0.19 2 -0.26 71 73
Activated_Oncogenes 0 0 -10000 0 -10000 0 0
MDM2 0.007 0.059 0.21 39 -0.32 2 41
MDM4 0.025 0.02 -10000 0 -0.44 1 1
IL12-mediated signaling events

Figure S16.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S16.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IL12/IL12R/TYK2/JAK2/SOCS1 -0.039 0.16 0.2 1 -0.41 61 62
TBX21 -0.17 0.47 0.54 1 -1.1 88 89
B2M 0.019 0.023 -10000 0 -10000 0 0
TYK2 0.013 0.042 -10000 0 -0.46 1 1
IL12RB1 -0.01 0.12 -10000 0 -0.47 31 31
GADD45B -0.11 0.35 -10000 0 -0.89 69 69
IL12RB2 -0.002 0.1 -10000 0 -0.46 24 24
GADD45G -0.1 0.35 -10000 0 -0.87 70 70
natural killer cell activation -0.001 0.019 -10000 0 -10000 0 0
RELB 0.026 0.021 -10000 0 -0.44 1 1
RELA 0.026 0.004 -10000 0 -10000 0 0
IL18 0.016 0.05 -10000 0 -0.45 5 5
IL2RA -0.006 0.12 -10000 0 -0.44 41 41
IFNG -0.007 0.12 -10000 0 -0.44 37 37
STAT3 (dimer) -0.11 0.34 -10000 0 -0.79 87 87
HLA-DRB5 -0.014 0.14 -10000 0 -0.44 53 53
FASLG -0.18 0.48 -10000 0 -1.1 92 92
NF kappa B2 p52/RelB -0.14 0.42 -10000 0 -0.98 90 90
CD4 0.009 0.088 -10000 0 -0.44 20 20
SOCS1 0.021 0.068 -10000 0 -0.44 11 11
EntrezGene:6955 -0.003 0.013 -10000 0 -10000 0 0
CD3D -0.003 0.11 -10000 0 -0.45 28 28
CD3E 0.002 0.095 -10000 0 -0.45 22 22
CD3G -0.017 0.13 -10000 0 -0.45 46 46
IL12Rbeta2/JAK2 0.002 0.11 -10000 0 -0.34 39 39
CCL3 -0.17 0.46 0.54 1 -1.1 89 90
CCL4 -0.16 0.44 0.54 1 -1.1 81 82
HLA-A 0.016 0.05 -10000 0 -0.44 5 5
IL18/IL18R 0.023 0.12 -10000 0 -0.32 51 51
NOS2 -0.21 0.53 -10000 0 -1.2 110 110
IL12/IL12R/TYK2/JAK2/SPHK2 -0.033 0.14 0.2 1 -0.39 52 53
IL1R1 -0.15 0.43 -10000 0 -1.1 82 82
IL4 -0.004 0.035 -10000 0 -10000 0 0
JAK2 0.001 0.085 -10000 0 -0.44 16 16
EntrezGene:6957 -0.003 0.013 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8 -0.14 0.39 -10000 0 -0.98 83 83
RAB7A -0.087 0.3 0.49 1 -0.82 48 49
lysosomal transport -0.081 0.28 0.49 1 -0.77 49 50
FOS -0.15 0.42 -10000 0 -0.99 91 91
STAT4 (dimer) -0.12 0.38 0.41 1 -0.87 91 92
STAT5A (dimer) -0.15 0.43 -10000 0 -0.99 93 93
GZMA -0.17 0.46 -10000 0 -1.1 87 87
GZMB -0.18 0.47 -10000 0 -1.2 83 83
HLX 0.023 0.04 -10000 0 -0.44 4 4
LCK -0.17 0.47 -10000 0 -1.1 95 95
TCR/CD3/MHC II/CD4 -0.079 0.27 0.21 1 -0.65 76 77
IL2/IL2R 0.026 0.12 -10000 0 -0.31 55 55
MAPK14 -0.12 0.37 -10000 0 -0.92 73 73
CCR5 -0.12 0.39 -10000 0 -1 69 69
IL1B -0.016 0.13 -10000 0 -0.47 40 40
STAT6 -0.014 0.11 -10000 0 -0.3 1 1
STAT4 0.002 0.11 -10000 0 -0.44 31 31
STAT3 0.026 0.004 -10000 0 -10000 0 0
STAT1 0.026 0.029 -10000 0 -0.44 2 2
NFKB1 0.025 0.02 -10000 0 -0.44 1 1
NFKB2 0.025 0.021 -10000 0 -0.44 1 1
IL12B 0.014 0.039 -10000 0 -0.12 1 1
CD8A -0.011 0.13 -10000 0 -0.45 43 43
CD8B -0.013 0.13 -10000 0 -0.45 42 42
T-helper 1 cell differentiation 0 0 -10000 0 -10000 0 0
natural killer cell mediated cytotoxicity 0.038 0.16 0.4 61 -0.2 1 62
IL2RB 0.012 0.081 -10000 0 -0.44 17 17
proteasomal ubiquitin-dependent protein catabolic process -0.1 0.34 0.38 2 -0.77 91 93
IL2RG 0.018 0.065 -10000 0 -0.44 11 11
IL12 0.002 0.1 -10000 0 -0.33 37 37
STAT5A 0.026 0.004 -10000 0 -10000 0 0
CD247 0.004 0.088 -10000 0 -0.45 19 19
IL2 -0.006 0.021 -10000 0 -10000 0 0
SPHK2 0.026 0.021 -10000 0 -0.44 1 1
FRAP1 0 0 -10000 0 -10000 0 0
IL12A -0.017 0.12 -10000 0 -0.46 37 37
IL12/IL12R/TYK2/JAK2 -0.18 0.53 -10000 0 -1.2 94 94
MAP2K3 -0.14 0.39 -10000 0 -0.9 91 91
RIPK2 0.023 0.009 -10000 0 -10000 0 0
MAP2K6 -0.11 0.37 -10000 0 -0.88 78 78
regulation of dendritic cell antigen processing and presentation 0 0 -10000 0 -10000 0 0
HLA-DRA 0.006 0.1 -10000 0 -0.43 28 28
IL18RAP -0.005 0.11 -10000 0 -0.43 35 35
IL12Rbeta1/TYK2 0.005 0.1 -10000 0 -0.36 32 32
EOMES -0.11 0.38 -10000 0 -1.2 57 57
STAT1 (dimer) -0.12 0.35 -10000 0 -0.8 95 95
T cell proliferation -0.078 0.28 0.36 1 -0.63 84 85
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
IL18R1 0.005 0.09 -10000 0 -0.44 21 21
CD8-positive alpha-beta T cell lineage commitment 0 0 -10000 0 -10000 0 0
NF kappa B1 p50/RelA -0.096 0.3 -10000 0 -0.69 90 90
ATF2 -0.11 0.34 -10000 0 -0.84 73 73
Glypican 1 network

Figure S17.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S17.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GPC1/FGF2 dimer/FGFR1 dimer 0.029 0.087 -10000 0 -0.3 31 31
fibroblast growth factor receptor signaling pathway 0.029 0.086 -10000 0 -0.3 31 31
LAMA1 -0.001 0.11 -10000 0 -0.44 30 30
PRNP 0.013 0.063 -10000 0 -0.44 10 10
GPC1/SLIT2 -0.008 0.13 -10000 0 -0.33 81 81
SMAD2 -0.016 0.035 0.18 3 -0.23 11 14
GPC1/PrPc/Cu2+ 0.019 0.054 -10000 0 -0.26 18 18
GPC1/Laminin alpha1 0.01 0.092 -10000 0 -0.32 38 38
TDGF1 -0.036 0.16 -10000 0 -0.44 75 75
CRIPTO/GPC1 -0.014 0.13 -10000 0 -0.32 83 83
APP/GPC1 0.032 0.046 -10000 0 -0.32 9 9
mol:NO 0 0 -10000 0 -10000 0 0
YES1 -0.051 0.094 -10000 0 -0.27 84 84
FLT1 0.019 0.023 -10000 0 -0.44 1 1
GPC1/TGFB/TGFBR1/TGFBR2 0.047 0.046 -10000 0 -0.27 11 11
SERPINC1 0.012 0.028 -10000 0 -10000 0 0
FYN -0.054 0.094 -10000 0 -0.27 87 87
FGR -0.062 0.1 -10000 0 -0.27 103 103
positive regulation of MAPKKK cascade -0.024 0.18 0.2 86 -0.36 91 177
SLIT2 -0.03 0.16 -10000 0 -0.44 75 75
GPC1/NRG 0.004 0.1 -10000 0 -0.33 45 45
NRG1 -0.009 0.12 -10000 0 -0.44 39 39
GPC1/VEGF165 homodimer/VEGFR1 homodimer 0.035 0.043 -10000 0 -0.27 7 7
LYN -0.049 0.09 -10000 0 -0.27 79 79
mol:Spermine -0.011 0.037 -10000 0 -0.32 8 8
cell growth 0.029 0.086 -10000 0 -0.3 31 31
BMP signaling pathway -0.02 0.056 0.44 8 -10000 0 8
SRC -0.043 0.092 -10000 0 -0.28 75 75
TGFBR1 0.024 0.034 -10000 0 -0.44 3 3
mol:Cu2+ 0 0 -10000 0 -10000 0 0
PLA2G2A -0.064 0.2 -10000 0 -0.44 120 120
GPC1 0.02 0.056 -10000 0 -0.44 8 8
TGFBR1 (dimer) 0.024 0.034 -10000 0 -0.44 3 3
VEGFA 0.026 0.004 -10000 0 -10000 0 0
BLK -0.077 0.12 -10000 0 -0.3 127 127
HCK -0.05 0.1 -10000 0 -0.28 87 87
FGF2 0.009 0.097 -10000 0 -0.44 24 24
FGFR1 0.019 0.054 -10000 0 -0.44 7 7
VEGFR1 homodimer 0.019 0.023 -10000 0 -0.44 1 1
TGFBR2 0.027 0.004 -10000 0 -10000 0 0
cell death 0.032 0.046 -10000 0 -0.32 9 9
ATIII/GPC1 0.033 0.045 -10000 0 -0.32 8 8
PLA2G2A/GPC1 -0.037 0.16 -10000 0 -0.32 126 126
LCK -0.062 0.1 -10000 0 -0.28 101 101
neuron differentiation 0.004 0.1 -10000 0 -0.33 45 45
PrPc/Cu2+ 0.01 0.044 -10000 0 -0.32 10 10
APP 0.024 0.021 -10000 0 -0.44 1 1
TGFBR2 (dimer) 0.027 0.004 -10000 0 -10000 0 0
BCR signaling pathway

Figure S18.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S18.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
JUN -0.07 0.17 0.38 2 -0.44 64 66
IKBKB -0.009 0.1 0.27 8 -0.31 23 31
AKT1 -0.044 0.094 0.3 7 -0.24 56 63
IKBKG -0.007 0.092 0.25 6 -0.28 23 29
CALM1 -0.019 0.14 0.31 6 -0.46 36 42
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
MAP3K1 -0.075 0.22 0.42 3 -0.54 75 78
MAP3K7 0.026 0.004 -10000 0 -10000 0 0
mol:Ca2+ -0.019 0.16 0.26 16 -0.47 39 55
DOK1 0.027 0.001 -10000 0 -10000 0 0
AP-1 -0.038 0.1 0.23 6 -0.26 51 57
LYN 0.023 0.009 -10000 0 -10000 0 0
BLNK 0.01 0.083 -10000 0 -0.44 18 18
SHC1 0.026 0.004 -10000 0 -10000 0 0
BCR complex -0.015 0.15 -10000 0 -0.36 84 84
CD22 -0.082 0.21 -10000 0 -0.57 69 69
CAMK2G -0.02 0.14 0.3 7 -0.43 36 43
CSNK2A1 0.021 0.011 -10000 0 -10000 0 0
INPP5D 0.006 0.095 -10000 0 -0.44 24 24
SHC/GRB2/SOS1 -0.021 0.1 -10000 0 -0.26 65 65
GO:0007205 -0.02 0.16 0.26 16 -0.48 39 55
SYK 0.026 0.004 -10000 0 -10000 0 0
ELK1 -0.021 0.15 0.3 4 -0.47 37 41
NFATC1 -0.086 0.19 0.3 3 -0.48 77 80
B-cell antigen/BCR complex -0.015 0.15 -10000 0 -0.36 84 84
PAG1/CSK 0.029 0.039 -10000 0 -0.32 6 6
NFKBIB 0.009 0.048 0.13 11 -0.13 28 39
HRAS -0.016 0.13 0.29 8 -0.4 36 44
NFKBIA 0.01 0.047 0.13 11 -0.12 29 40
NF-kappa-B/RelA/I kappa B beta 0.014 0.042 0.14 9 -0.15 1 10
RasGAP/Csk 0.002 0.17 -10000 0 -0.33 103 103
mol:GDP -0.014 0.15 0.27 15 -0.46 37 52
PTEN 0.025 0.006 -10000 0 -10000 0 0
CD79B 0.014 0.084 -10000 0 -0.44 18 18
NF-kappa-B/RelA/I kappa B alpha 0.014 0.041 0.14 9 -0.15 1 10
GRB2 0.026 0.004 -10000 0 -10000 0 0
PI3K/BCAP/CD19 -0.074 0.2 0.54 1 -0.52 71 72
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
mol:IP3 -0.019 0.16 0.26 17 -0.48 40 57
CSK 0.025 0.021 -10000 0 -0.44 1 1
FOS -0.028 0.14 0.29 4 -0.44 39 43
CHUK -0.019 0.11 0.26 6 -0.32 44 50
IBTK 0.018 0.062 -10000 0 -0.44 10 10
CARD11/BCL10/MALT1/TAK1 -0.015 0.15 0.33 2 -0.43 44 46
PTPN6 -0.082 0.2 -10000 0 -0.56 66 66
RELA 0.026 0.004 -10000 0 -10000 0 0
BCL2A1 0.007 0.032 -10000 0 -0.12 1 1
VAV2 -0.097 0.22 -10000 0 -0.59 76 76
ubiquitin-dependent protein catabolic process 0.011 0.048 0.14 11 -0.12 28 39
BTK -0.026 0.26 -10000 0 -1.1 32 32
CD19 -0.087 0.21 -10000 0 -0.58 69 69
MAP4K1 -0.007 0.12 -10000 0 -0.44 42 42
CD72 0.021 0.057 -10000 0 -0.44 8 8
PAG1 0.019 0.045 -10000 0 -0.44 5 5
MAPK14 -0.063 0.18 0.41 4 -0.46 73 77
SH3BP5 0.02 0.052 -10000 0 -0.44 7 7
PIK3AP1 -0.022 0.16 0.32 3 -0.51 37 40
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 -0.039 0.21 -10000 0 -0.49 74 74
RAF1 -0.017 0.12 0.28 8 -0.39 34 42
RasGAP/p62DOK/SHIP -0.007 0.18 -10000 0 -0.32 121 121
CD79A -0.035 0.17 -10000 0 -0.44 80 80
re-entry into mitotic cell cycle -0.038 0.1 0.23 6 -0.26 49 55
RASA1 0.024 0.028 -10000 0 -0.44 2 2
MAPK3 -0.017 0.11 0.25 8 -0.36 26 34
MAPK1 -0.017 0.1 0.24 6 -0.36 26 32
CD72/SHP1 -0.063 0.2 0.27 2 -0.54 65 67
NFKB1 0.025 0.02 -10000 0 -0.44 1 1
MAPK8 -0.064 0.18 0.35 4 -0.46 75 79
actin cytoskeleton organization -0.073 0.19 0.36 5 -0.49 74 79
NF-kappa-B/RelA 0.029 0.081 0.25 11 -0.2 12 23
Calcineurin -0.003 0.13 0.32 2 -0.4 34 36
PI3K -0.082 0.17 -10000 0 -0.46 71 71
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 -0.018 0.16 0.3 4 -0.49 40 44
SOS1 0.027 0.002 -10000 0 -10000 0 0
Bam32/HPK1 -0.11 0.33 -10000 0 -0.84 84 84
DAPP1 -0.13 0.36 -10000 0 -0.95 81 81
cytokine secretion -0.08 0.17 0.3 3 -0.44 77 80
mol:DAG -0.019 0.16 0.26 17 -0.48 40 57
PLCG2 0.015 0.076 -10000 0 -0.44 15 15
MAP2K1 -0.019 0.11 0.25 7 -0.38 30 37
B-cell antigen/BCR complex/FcgammaRIIB -0.019 0.18 0.2 5 -0.38 101 106
mol:PI-3-4-5-P3 -0.071 0.11 0.2 2 -0.33 64 66
ETS1 -0.02 0.12 0.3 6 -0.41 33 39
B-cell antigen/BCR complex/LYN/SYK/BLNK 0.019 0.13 -10000 0 -0.28 76 76
B-cell antigen/BCR complex/LYN -0.055 0.2 -10000 0 -0.48 77 77
MALT1 0.018 0.03 -10000 0 -0.44 2 2
TRAF6 0.025 0.02 -10000 0 -0.44 1 1
RAC1 -0.08 0.21 0.31 4 -0.53 74 78
B-cell antigen/BCR complex/LYN/SYK -0.041 0.21 -10000 0 -0.56 59 59
CARD11 -0.022 0.18 0.29 20 -0.49 48 68
FCGR2B -0.017 0.14 -10000 0 -0.44 57 57
PPP3CA 0.026 0.005 -10000 0 -10000 0 0
BCL10 0.023 0.04 -10000 0 -0.44 4 4
IKK complex 0 0.05 0.15 16 -0.13 10 26
PTPRC -0.003 0.12 -10000 0 -0.44 37 37
PDPK1 -0.05 0.08 0.18 6 -0.23 58 64
PPP3CB 0.026 0.004 -10000 0 -10000 0 0
PPP3CC 0.017 0.036 -10000 0 -0.44 3 3
POU2F2 0.01 0.034 0.19 3 -10000 0 3
amb2 Integrin signaling

Figure S19.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S19.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
alphaM/beta2 Integrin/proMMP-2 0.002 0.15 0.2 6 -0.39 55 61
alphaM/beta2 Integrin/GPIbA 0.002 0.13 0.2 4 -0.36 52 56
alphaM/beta2 Integrin/proMMP-9 0 0.13 0.21 12 -0.39 38 50
PLAUR 0.026 0.005 -10000 0 -10000 0 0
HMGB1 0.001 0.078 -10000 0 -0.45 15 15
alphaM/beta2 Integrin/Talin 0.01 0.13 -10000 0 -0.36 45 45
AGER 0.006 0.075 -10000 0 -0.37 16 16
RAP1A 0.025 0.02 -10000 0 -0.44 1 1
SELPLG 0.016 0.071 -10000 0 -0.44 13 13
mol:LDL 0 0 -10000 0 -10000 0 0
alphaM/beta2 Integrin/RAGE/HMGB1 -0.006 0.15 -10000 0 -0.29 100 100
mol:GTP 0 0 -10000 0 -10000 0 0
MMP9 0.004 0.082 -10000 0 -0.44 17 17
CYR61 0.025 0.052 -10000 0 -0.44 6 6
TLN1 0.025 0.02 -10000 0 -0.44 1 1
Rap1/GTP -0.051 0.15 -10000 0 -0.37 71 71
RHOA 0.025 0.02 -10000 0 -0.44 1 1
P-selectin oligomer -0.026 0.15 -10000 0 -0.44 66 66
MYH2 -0.072 0.16 0.23 4 -0.44 56 60
MST1R 0.023 0.04 -10000 0 -0.44 4 4
leukocyte activation during inflammatory response -0.004 0.14 -10000 0 -0.3 86 86
APOB -0.014 0.14 -10000 0 -0.44 48 48
mol:GDP 0 0 -10000 0 -10000 0 0
complement component iC3b receptor activity 0 0 -10000 0 -10000 0 0
MMP2 0.01 0.095 -10000 0 -0.44 23 23
JAM3 0.027 0.009 -10000 0 -10000 0 0
GP1BA 0.012 0.061 -10000 0 -0.44 9 9
alphaM/beta2 Integrin/CTGF 0.011 0.13 0.2 6 -0.36 46 52
alphaM/beta2 Integrin -0.072 0.16 -10000 0 -0.43 68 68
JAM3 homodimer 0.027 0.009 -10000 0 -10000 0 0
ICAM2 0.023 0.04 -10000 0 -0.44 4 4
ICAM1 0.025 0.029 -10000 0 -0.44 2 2
phagocytosis triggered by activation of immune response cell surface activating receptor -0.071 0.16 -10000 0 -0.42 68 68
cell adhesion 0.002 0.13 0.2 4 -0.35 52 56
NFKB1 -0.037 0.2 0.41 5 -0.43 76 81
THY1 0.023 0.04 -10000 0 -0.44 4 4
RhoA/GDP 0.019 0.014 -10000 0 -0.32 1 1
Lipoprotein(a) 0.015 0.09 -10000 0 -0.27 48 48
alphaM/beta2 Integrin/LRP/tPA 0.015 0.13 0.21 1 -0.35 46 47
IL6 -0.082 0.25 0.33 5 -0.65 72 77
ITGB2 0.001 0.093 -10000 0 -0.45 20 20
elevation of cytosolic calcium ion concentration 0.02 0.12 0.24 1 -0.34 45 46
alphaM/beta2 Integrin/JAM2/JAM3 0.01 0.15 0.22 4 -0.36 62 66
JAM2 0 0.11 -10000 0 -0.44 33 33
alphaM/beta2 Integrin/ICAM1 0.021 0.14 -10000 0 -0.32 63 63
alphaM/beta2 Integrin/uPA/Plg 0 0.15 -10000 0 -0.33 77 77
RhoA/GTP -0.076 0.17 0.24 1 -0.41 76 77
positive regulation of phagocytosis -0.052 0.15 0.18 3 -0.39 65 68
Ron/MSP 0.027 0.074 -10000 0 -0.33 22 22
alphaM/beta2 Integrin/uPAR/uPA 0.022 0.13 0.25 1 -0.34 45 46
alphaM/beta2 Integrin/uPAR 0.011 0.13 0.19 1 -0.36 44 45
PLAU 0.024 0.041 -10000 0 -0.44 4 4
PLAT 0.019 0.049 -10000 0 -0.44 6 6
actin filament polymerization -0.07 0.15 0.23 4 -0.42 57 61
MST1 0.014 0.087 -10000 0 -0.44 19 19
alphaM/beta2 Integrin/lipoprotein(a) 0.001 0.15 0.19 1 -0.3 86 87
TNF -0.056 0.21 0.35 4 -0.52 63 67
RAP1B 0.027 0.002 -10000 0 -10000 0 0
alphaM/beta2 Integrin/uPA 0.01 0.13 0.2 4 -0.36 48 52
fibrinolysis -0.002 0.15 -10000 0 -0.33 77 77
HCK 0.006 0.071 -10000 0 -0.44 13 13
dendritic cell antigen processing and presentation -0.071 0.16 -10000 0 -0.42 68 68
VTN 0.008 0.093 -10000 0 -0.44 21 21
alphaM/beta2 Integrin/CYR61 0.01 0.13 0.2 9 -0.36 49 58
LPA 0.011 0.037 -10000 0 -0.44 1 1
LRP1 0.023 0.044 -10000 0 -0.44 5 5
cell migration -0.014 0.14 0.22 14 -0.42 43 57
FN1 -0.01 0.14 -10000 0 -0.44 52 52
alphaM/beta2 Integrin/Thy1 0.01 0.13 0.2 1 -0.37 46 47
MPO 0.003 0.1 -10000 0 -0.44 27 27
KNG1 -0.027 0.15 -10000 0 -0.44 64 64
RAP1/GDP 0.034 0.015 -10000 0 -0.27 1 1
ROCK1 -0.073 0.16 0.23 3 -0.44 58 61
ELA2 0 0 -10000 0 -10000 0 0
PLG -0.028 0.11 -10000 0 -0.44 37 37
CTGF 0.028 0.025 -10000 0 -0.44 1 1
alphaM/beta2 Integrin/Hck 0 0.12 0.21 7 -0.39 35 42
ITGAM -0.012 0.12 -10000 0 -0.45 38 38
alphaM/beta2 Integrin/P-Selectin/PSGL1 -0.01 0.18 0.24 3 -0.36 93 96
HP -0.003 0.12 -10000 0 -0.44 34 34
leukocyte adhesion -0.025 0.16 0.22 2 -0.4 64 66
SELP -0.027 0.15 -10000 0 -0.44 66 66
Ephrin A reverse signaling

Figure S20.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S20.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAPKKK cascade 0.009 0.09 -10000 0 -0.27 51 51
EFNA5 -0.01 0.14 -10000 0 -0.44 51 51
FYN -0.04 0.071 0.18 1 -0.25 53 54
neuron projection morphogenesis 0.009 0.09 -10000 0 -0.27 51 51
cell-cell signaling 0 0 -10000 0 -10000 0 0
Ephrin A5/EPHA5 0.009 0.091 -10000 0 -0.27 51 51
EPHA5 0.007 0.026 -10000 0 -10000 0 0
LPA receptor mediated events

Figure S21.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S21.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GNB1/GNG2 0.023 0.096 -10000 0 -0.27 49 49
NF kappa B1 p50/RelA/I kappa B alpha -0.011 0.11 0.28 2 -0.33 23 25
AP1 -0.012 0.12 -10000 0 -0.25 97 97
mol:PIP3 -0.038 0.09 -10000 0 -0.24 78 78
AKT1 -0.014 0.079 0.23 5 -0.34 13 18
PTK2B -0.053 0.12 0.18 2 -0.29 61 63
RHOA -0.002 0.069 0.23 5 -0.34 12 17
PIK3CB 0.024 0.034 -10000 0 -0.44 3 3
mol:Ca2+ -0.018 0.082 0.2 4 -0.27 30 34
MAGI3 0.024 0.028 -10000 0 -0.44 2 2
RELA 0.026 0.004 -10000 0 -10000 0 0
apoptosis -0.029 0.1 -10000 0 -0.27 82 82
HRAS/GDP 0.019 0.015 -10000 0 -0.32 1 1
positive regulation of microtubule depolymerization -0.065 0.12 0.24 4 -0.34 47 51
NF kappa B1 p50/RelA -0.017 0.12 -10000 0 -0.32 44 44
endothelial cell migration -0.023 0.13 -10000 0 -0.42 48 48
ADCY4 -0.036 0.13 0.24 1 -0.39 52 53
ADCY5 -0.051 0.16 0.24 1 -0.43 61 62
ADCY6 -0.029 0.13 0.24 1 -0.38 51 52
ADCY7 -0.03 0.13 0.24 1 -0.39 50 51
ADCY1 -0.034 0.13 -10000 0 -0.39 50 50
ADCY2 -0.044 0.15 0.24 1 -0.44 57 58
ADCY3 -0.029 0.13 0.24 1 -0.38 51 52
ADCY8 -0.029 0.12 0.23 2 -0.38 47 49
ADCY9 -0.031 0.13 0.24 1 -0.38 52 53
GSK3B -0.054 0.11 0.18 3 -0.33 41 44
arachidonic acid secretion -0.031 0.13 -10000 0 -0.35 58 58
GNG2 0.021 0.045 -10000 0 -0.44 5 5
TRIP6 -0.006 0.08 -10000 0 -0.37 23 23
GNAO1 -0.024 0.1 -10000 0 -0.31 58 58
HRAS 0.026 0.021 -10000 0 -0.44 1 1
NFKBIA -0.031 0.11 0.27 3 -0.32 38 41
GAB1 0.026 0.005 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
lamellipodium assembly -0.045 0.28 -10000 0 -0.86 57 57
JUN 0.023 0.04 -10000 0 -0.44 4 4
LPA/LPA2/NHERF2 0.031 0.033 -10000 0 -0.5 1 1
TIAM1 -0.068 0.32 -10000 0 -1 57 57
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
mol:IP3 -0.024 0.081 0.2 4 -0.27 30 34
PLCB3 0.006 0.042 0.18 7 -0.46 2 9
FOS 0.013 0.082 -10000 0 -0.44 17 17
positive regulation of mitosis -0.031 0.13 -10000 0 -0.35 58 58
LPA/LPA1-2-3 0.009 0.12 -10000 0 -0.26 83 83
mol:Ca ++ 0 0 -10000 0 -10000 0 0
JNK cascade 0 0.001 -10000 0 -10000 0 0
BCAR1 0.025 0.029 -10000 0 -0.44 2 2
stress fiber formation -0.032 0.1 0.2 3 -0.31 37 40
GNAZ -0.019 0.095 -10000 0 -0.28 60 60
EGFR/PI3K-beta/Gab1 -0.025 0.1 -10000 0 -0.25 78 78
positive regulation of dendritic cell cytokine production 0.008 0.12 -10000 0 -0.26 83 83
LPA/LPA2/MAGI-3 0.031 0.034 -10000 0 -0.28 3 3
ARHGEF1 0.004 0.097 0.19 53 -0.24 49 102
GNAI2 -0.01 0.085 -10000 0 -0.28 46 46
GNAI3 -0.011 0.086 -10000 0 -0.28 48 48
GNAI1 -0.015 0.098 -10000 0 -0.3 51 51
LPA/LPA3 -0.003 0.089 -10000 0 -0.26 53 53
LPA/LPA2 0.017 0.028 -10000 0 -0.12 18 18
LPA/LPA1 -0.008 0.1 -10000 0 -0.33 48 48
HB-EGF/EGFR 0.001 0.052 0.17 2 -0.27 16 18
HBEGF -0.013 0.069 0.23 16 -0.32 17 33
mol:DAG -0.024 0.081 0.2 4 -0.27 30 34
cAMP biosynthetic process -0.037 0.14 0.3 5 -0.39 56 61
NFKB1 0.025 0.02 -10000 0 -0.44 1 1
SRC 0.015 0.023 -10000 0 -0.44 1 1
GNB1 0.026 0.006 -10000 0 -10000 0 0
LYN -0.014 0.11 0.26 6 -0.31 41 47
GNAQ -0.013 0.074 0.12 1 -0.26 43 44
LPAR2 0.025 0.023 -10000 0 -0.44 1 1
LPAR3 -0.008 0.12 -10000 0 -0.44 38 38
LPAR1 -0.007 0.12 -10000 0 -0.36 48 48
IL8 -0.044 0.19 0.32 2 -0.45 81 83
PTK2 -0.031 0.089 0.16 4 -0.25 70 74
Rac1/GDP 0.018 0.006 -10000 0 -10000 0 0
CASP3 -0.029 0.1 -10000 0 -0.27 82 82
EGFR 0.02 0.045 -10000 0 -0.44 5 5
PLCG1 -0.018 0.079 -10000 0 -0.27 43 43
PLD2 -0.037 0.094 0.18 3 -0.25 81 84
G12/G13 0.023 0.09 -10000 0 -0.26 47 47
PI3K-beta -0.004 0.08 -10000 0 -0.35 15 15
cell migration -0.011 0.096 -10000 0 -0.26 56 56
SLC9A3R2 0.025 0.02 -10000 0 -0.44 1 1
PXN -0.032 0.1 0.2 3 -0.32 37 40
HRAS/GTP -0.033 0.13 -10000 0 -0.36 58 58
RAC1 0.024 0.008 -10000 0 -10000 0 0
MMP9 0.003 0.082 -10000 0 -0.44 17 17
PRKCE 0.026 0.002 -10000 0 -10000 0 0
PRKCD -0.019 0.082 0.22 6 -0.27 27 33
Gi(beta/gamma) -0.03 0.13 -10000 0 -0.38 53 53
mol:LPA -0.004 0.029 -10000 0 -0.16 17 17
TRIP6/p130 Cas/FAK1/Paxillin -0.004 0.12 -10000 0 -0.38 25 25
MAPKKK cascade -0.031 0.13 -10000 0 -0.35 58 58
contractile ring contraction involved in cytokinesis 0 0.07 0.23 5 -0.34 12 17
mol:GDP 0 0 -10000 0 -10000 0 0
GNA14 -0.018 0.083 0.12 1 -0.26 53 54
GNA15 -0.018 0.082 -10000 0 -0.26 51 51
GNA12 0.024 0.008 -10000 0 -10000 0 0
GNA13 0.024 0.028 -10000 0 -0.44 2 2
MAPT -0.067 0.12 0.24 4 -0.35 47 51
GNA11 -0.013 0.073 -10000 0 -0.25 42 42
Rac1/GTP -0.049 0.29 -10000 0 -0.91 57 57
MMP2 -0.023 0.13 -10000 0 -0.42 48 48
EGFR-dependent Endothelin signaling events

Figure S22.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S22.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HRAS 0.026 0.021 -10000 0 -0.44 1 1
EGFR 0.02 0.045 -10000 0 -0.44 5 5
EGF/EGFR 0 0.12 -10000 0 -0.24 100 100
EGF/EGFR dimer/SHC/GRB2/SOS1 0.032 0.11 -10000 0 -0.24 73 73
mol:GTP 0 0 -10000 0 -10000 0 0
EDNRA 0.016 0.075 -10000 0 -0.44 14 14
response to oxidative stress 0 0 -10000 0 -10000 0 0
EGF -0.03 0.17 -10000 0 -0.44 80 80
EGF/EGFR dimer/SHC 0.011 0.12 -10000 0 -0.27 73 73
mol:GDP 0.026 0.11 -10000 0 -0.24 73 73
mol:Ca2+ 0 0 -10000 0 -10000 0 0
EDN1 0.015 0.082 -10000 0 -0.44 17 17
GRB2/SOS1 0.039 0.007 -10000 0 -10000 0 0
HRAS/GTP 0.01 0.094 -10000 0 -0.22 73 73
SHC1 0.026 0.004 -10000 0 -10000 0 0
HRAS/GDP 0.024 0.1 -10000 0 -0.23 73 73
FRAP1 -0.049 0.071 0.15 3 -0.23 73 76
EGF/EGFR dimer -0.004 0.13 -10000 0 -0.32 75 75
SOS1 0.027 0.002 -10000 0 -10000 0 0
GRB2 0.026 0.004 -10000 0 -10000 0 0
ETA receptor/Endothelin-1 0.022 0.087 -10000 0 -0.34 29 29
Syndecan-4-mediated signaling events

Figure S23.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S23.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.027 0.15 -10000 0 -0.44 54 54
Syndecan-4/Syndesmos 0.003 0.2 0.36 1 -0.44 66 67
positive regulation of JNK cascade 0.007 0.2 0.34 1 -0.42 70 71
Syndecan-4/ADAM12 -0.01 0.22 0.36 1 -0.46 75 76
CCL5 0.012 0.091 -10000 0 -0.44 21 21
Rac1/GDP 0.018 0.006 -10000 0 -10000 0 0
DNM2 0.026 0.02 -10000 0 -0.44 1 1
ITGA5 0.026 0.036 -10000 0 -0.44 3 3
SDCBP 0.015 0.062 -10000 0 -0.44 10 10
PLG -0.03 0.11 -10000 0 -0.41 39 39
ADAM12 -0.002 0.13 -10000 0 -0.44 42 42
mol:GTP 0 0 -10000 0 -10000 0 0
NUDT16L1 0.026 0.006 -10000 0 -10000 0 0
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
Syndecan-4/PKC alpha -0.023 0.025 -10000 0 -10000 0 0
Syndecan-4/Laminin alpha1 -0.027 0.2 0.31 2 -0.46 71 73
Syndecan-4/CXCL12/CXCR4 0.007 0.21 0.35 1 -0.44 70 71
Syndecan-4/Laminin alpha3 -0.018 0.2 -10000 0 -0.45 66 66
MDK 0.021 0.06 -10000 0 -0.44 9 9
Syndecan-4/FZD7 0.002 0.21 0.33 2 -0.45 66 68
Syndecan-4/Midkine 0 0.21 0.36 1 -0.45 69 70
FZD7 0.025 0.041 -10000 0 -0.44 4 4
Syndecan-4/FGFR1/FGF -0.01 0.2 0.34 1 -0.44 66 67
THBS1 0.02 0.053 -10000 0 -0.44 7 7
integrin-mediated signaling pathway -0.007 0.21 0.3 1 -0.45 72 73
positive regulation of MAPKKK cascade 0.007 0.2 0.34 1 -0.42 70 71
Syndecan-4/TACI -0.021 0.21 0.35 1 -0.46 69 70
CXCR4 0.022 0.061 -10000 0 -0.44 9 9
cell adhesion -0.015 0.086 0.19 11 -0.27 48 59
Syndecan-4/Dynamin 0.002 0.21 0.36 1 -0.44 66 67
Syndecan-4/TSP1 -0.002 0.21 0.36 1 -0.45 68 69
Syndecan-4/GIPC 0 0.21 0.33 2 -0.44 66 68
Syndecan-4/RANTES -0.004 0.21 0.36 1 -0.46 67 68
ITGB1 0.027 0.002 -10000 0 -10000 0 0
LAMA1 -0.001 0.11 -10000 0 -0.44 30 30
LAMA3 0.018 0.054 -10000 0 -0.44 7 7
RAC1 0.024 0.008 -10000 0 -10000 0 0
PRKCA 0.02 0.12 0.82 12 -0.47 1 13
Syndecan-4/alpha-Actinin -0.003 0.2 0.3 1 -0.44 66 67
TFPI 0.018 0.069 -10000 0 -0.44 12 12
F2 0.005 0.15 0.15 3 -0.42 54 57
alpha5/beta1 Integrin 0.039 0.028 -10000 0 -0.32 3 3
positive regulation of cell adhesion -0.033 0.2 0.29 1 -0.45 71 72
ACTN1 0.025 0.006 -10000 0 -10000 0 0
TNC 0.003 0.12 -10000 0 -0.44 34 34
Syndecan-4/CXCL12 0.001 0.21 0.33 2 -0.45 67 69
FGF6 -0.017 0.008 -10000 0 -10000 0 0
RHOA 0.025 0.02 -10000 0 -0.44 1 1
CXCL12 0.023 0.054 -10000 0 -0.44 7 7
TNFRSF13B -0.002 0.11 -10000 0 -0.44 29 29
FGF2 0.009 0.097 -10000 0 -0.44 24 24
FGFR1 0.019 0.054 -10000 0 -0.44 7 7
Syndecan-4/PI-4-5-P2 -0.063 0.16 -10000 0 -0.44 66 66
mol:GDP 0 0 -10000 0 -10000 0 0
FN1 -0.045 0.13 -10000 0 -0.4 58 58
cell migration -0.01 0.014 -10000 0 -10000 0 0
PRKCD 0.005 0.03 -10000 0 -10000 0 0
vasculogenesis -0.001 0.2 0.32 2 -0.44 68 70
SDC4 -0.039 0.18 -10000 0 -0.46 64 64
Syndecan-4/Tenascin C -0.009 0.22 -10000 0 -0.47 72 72
Syndecan-4/PI-4-5-P2/PKC alpha -0.019 0.02 -10000 0 -10000 0 0
Syndecan-4/Syntenin -0.01 0.2 0.36 1 -0.44 63 64
MMP9 0.001 0.082 -10000 0 -0.44 17 17
Rac1/GTP -0.016 0.088 0.2 11 -0.28 48 59
cytoskeleton organization 0.004 0.2 0.35 1 -0.43 66 67
GIPC1 0.023 0.04 -10000 0 -0.44 4 4
Syndecan-4/TFPI -0.001 0.21 0.33 2 -0.45 67 69
Syndecan-1-mediated signaling events

Figure S24.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S24.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 0.019 0.06 -10000 0 -0.44 9 9
CCL5 0.012 0.091 -10000 0 -0.44 21 21
SDCBP 0.015 0.062 -10000 0 -0.44 10 10
FGFR/FGF2/Syndecan-1 -0.01 0.15 0.21 6 -0.32 67 73
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
RP11-540L11.1 0 0 -10000 0 -10000 0 0
Syndecan-1/Laminin-5 -0.043 0.13 -10000 0 -0.43 34 34
Syndecan-1/Syntenin -0.016 0.14 0.24 5 -0.4 37 42
MAPK3 -0.016 0.14 0.21 4 -0.37 39 43
HGF/MET 0.019 0.083 -10000 0 -0.32 31 31
TGFB1/TGF beta receptor Type II 0.019 0.059 -10000 0 -0.44 9 9
BSG 0.025 0.02 -10000 0 -0.44 1 1
keratinocyte migration -0.043 0.13 -10000 0 -0.43 34 34
Syndecan-1/RANTES -0.017 0.16 0.29 2 -0.4 49 51
Syndecan-1/CD147 -0.002 0.15 0.32 1 -0.38 40 41
Syndecan-1/Syntenin/PIP2 -0.017 0.14 0.28 2 -0.39 37 39
LAMA5 -0.003 0.09 -10000 0 -0.44 22 22
positive regulation of cell-cell adhesion -0.017 0.14 0.27 2 -0.38 37 39
MMP7 -0.025 0.16 -10000 0 -0.44 73 73
HGF 0.001 0.11 -10000 0 -0.44 31 31
Syndecan-1/CASK -0.025 0.14 -10000 0 -0.3 72 72
Syndecan-1/HGF/MET -0.01 0.17 0.29 2 -0.41 47 49
regulation of cell adhesion -0.023 0.13 0.27 5 -0.37 36 41
HPSE 0.021 0.053 -10000 0 -0.44 7 7
positive regulation of cell migration -0.01 0.15 0.21 6 -0.32 67 73
SDC1 -0.009 0.14 0.2 1 -0.32 66 67
Syndecan-1/Collagen -0.01 0.15 0.21 6 -0.32 67 73
PPIB 0.025 0.006 -10000 0 -10000 0 0
MET 0.025 0.021 -10000 0 -0.44 1 1
PRKACA 0.026 0.003 -10000 0 -10000 0 0
MMP9 0.004 0.082 -10000 0 -0.44 17 17
MAPK1 -0.017 0.14 0.2 5 -0.36 40 45
homophilic cell adhesion -0.016 0.15 0.24 8 -0.37 45 53
MMP1 -0.032 0.17 -10000 0 -0.44 78 78
IL1-mediated signaling events

Figure S25.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S25.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
UBC13/UEV1A 0.022 0.036 -10000 0 -0.32 3 3
PRKCZ 0.025 0.021 -10000 0 -0.44 1 1
MAP3K7IP2 0 0 -10000 0 -10000 0 0
ERC1 0.026 0.006 -10000 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 0.001 0.069 -10000 0 -0.25 22 22
IRAK/TOLLIP 0.018 0.055 0.19 34 -0.3 4 38
IKBKB 0.023 0.009 -10000 0 -10000 0 0
IKBKG 0.026 0.02 -10000 0 -0.44 1 1
IL1 alpha/IL1R2 -0.003 0.14 -10000 0 -0.36 73 73
IL1A -0.008 0.14 -10000 0 -0.44 50 50
IL1B -0.047 0.1 -10000 0 -0.35 52 52
IRAK/TRAF6/p62/Atypical PKCs 0.091 0.087 -10000 0 -0.32 5 5
IL1R2 0.003 0.12 -10000 0 -0.44 34 34
IL1R1 0.021 0.06 -10000 0 -0.44 9 9
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP 0.027 0.074 0.24 6 -0.32 5 11
TOLLIP 0.025 0.02 -10000 0 -0.44 1 1
TICAM2 0.004 0.087 -10000 0 -0.44 20 20
MAP3K3 0.024 0.028 -10000 0 -0.44 2 2
TAK1/TAB1/TAB2 0.018 0.003 -10000 0 -10000 0 0
IKK complex/ELKS 0.057 0.1 0.27 7 -0.45 5 12
JUN 0.039 0.098 0.15 224 -0.23 17 241
MAP3K7 0.026 0.004 -10000 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/PI3K 0.024 0.12 -10000 0 -0.27 71 71
IL1 alpha/IL1R1/IL1RAP/MYD88 0.035 0.11 -10000 0 -0.26 65 65
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 0.045 0.11 -10000 0 -0.25 65 65
IL1 beta fragment/IL1R1/IL1RAP -0.005 0.11 -10000 0 -0.29 69 69
NFKB1 0.025 0.02 -10000 0 -0.44 1 1
MAPK8 0.049 0.1 0.16 232 -0.22 13 245
IRAK1 -0.001 0.058 0.2 35 -0.27 4 39
IL1RN/IL1R1 0.018 0.1 -10000 0 -0.35 38 38
IRAK4 0.027 0.002 -10000 0 -10000 0 0
PRKCI 0.024 0.034 -10000 0 -0.44 3 3
TRAF6 0.025 0.02 -10000 0 -0.44 1 1
PI3K 0.035 0.031 -10000 0 -0.32 4 4
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP -0.004 0.08 -10000 0 -0.28 29 29
CHUK 0.023 0.035 -10000 0 -0.44 3 3
IL1 beta fragment/IL1R1/IL1RAP/MYD88s -0.005 0.11 -10000 0 -0.29 69 69
IL1 beta/IL1R2 -0.019 0.14 -10000 0 -0.34 74 74
IRAK/TRAF6/TAK1/TAB1/TAB2 0.021 0.049 0.18 1 -0.23 5 6
NF kappa B1 p50/RelA 0.004 0.11 -10000 0 -0.26 70 70
IRAK3 0.01 0.092 -10000 0 -0.44 22 22
IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 0.015 0.12 -10000 0 -0.27 84 84
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP -0.004 0.088 -10000 0 -0.24 67 67
IL1 alpha/IL1R1/IL1RAP 0.02 0.11 -10000 0 -0.29 65 65
RELA 0.026 0.004 -10000 0 -10000 0 0
MAP3K7IP1 0 0 -10000 0 -10000 0 0
SQSTM1 0.026 0.004 -10000 0 -10000 0 0
MYD88 0.026 0.003 -10000 0 -10000 0 0
IRAK/TRAF6/MEKK3 0.084 0.086 0.21 1 -0.25 6 7
IL1RAP 0.018 0.062 -10000 0 -0.44 10 10
UBE2N 0.025 0.02 -10000 0 -0.44 1 1
IRAK/TRAF6 -0.022 0.081 -10000 0 -0.33 10 10
CASP1 0.009 0.09 -10000 0 -0.44 21 21
IL1RN/IL1R2 0.006 0.13 -10000 0 -0.38 55 55
IL1 beta fragment/IL1R1/IL1RAP/MYD88 0.008 0.11 -10000 0 -0.27 69 69
TMEM189-UBE2V1 0.005 0.045 -10000 0 -0.44 3 3
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP 0.035 0.089 -10000 0 -0.34 9 9
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
IL1RN 0.003 0.11 -10000 0 -0.44 33 33
TRAF6/TAK1/TAB1/TAB2 0.028 0.037 -10000 0 -0.23 4 4
MAP2K6 0.055 0.11 0.17 235 -0.23 13 248
TCGA08_retinoblastoma

Figure S26.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S26.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDKN2B 0.01 0.069 -10000 0 -0.4 13 13
CDKN2C 0.029 0.018 -10000 0 -10000 0 0
CDKN2A -0.007 0.12 -10000 0 -0.42 37 37
CCND2 0.007 0.058 0.18 41 -10000 0 41
RB1 0.002 0.075 0.26 11 -0.2 39 50
CDK4 0.011 0.062 0.21 41 -0.14 1 42
CDK6 0.012 0.063 0.21 41 -10000 0 41
G1/S progression -0.001 0.076 0.2 43 -0.27 10 53
Thromboxane A2 receptor signaling

Figure S27.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S27.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGM2 0.008 0.06 -10000 0 -0.45 9 9
GNB1/GNG2 -0.034 0.065 -10000 0 -0.19 67 67
AKT1 -0.03 0.11 0.29 5 -0.26 52 57
EGF -0.03 0.17 -10000 0 -0.44 80 80
mol:TXA2 0 0.001 -10000 0 -10000 0 0
FGR -0.032 0.079 0.32 2 -0.36 13 15
mol:Ca2+ -0.038 0.13 0.31 4 -0.31 77 81
LYN -0.023 0.058 0.32 2 -0.31 4 6
RhoA/GTP -0.017 0.053 -10000 0 -0.14 62 62
mol:PGI2 0 0 -10000 0 -10000 0 0
SYK -0.044 0.14 0.31 5 -0.35 69 74
GNG2 0.021 0.045 -10000 0 -0.44 5 5
ARRB2 0.022 0.01 -10000 0 -10000 0 0
TP alpha/Gq family/GDP/G beta5/gamma2 -0.022 0.13 -10000 0 -0.52 24 24
G beta5/gamma2 -0.039 0.086 -10000 0 -0.25 64 64
PRKCH -0.043 0.14 0.29 4 -0.36 73 77
DNM1 0.023 0.045 -10000 0 -0.44 5 5
TXA2/TP beta/beta Arrestin3 0.006 0.041 -10000 0 -0.51 2 2
mol:GTP 0 0.001 -10000 0 -10000 0 0
PTGDR -0.004 0.14 -10000 0 -0.44 47 47
G12 family/GTP -0.043 0.12 -10000 0 -0.3 72 72
ADRBK1 0.026 0.021 -10000 0 -0.44 1 1
ADRBK2 0.019 0.056 -10000 0 -0.44 8 8
RhoA/GTP/ROCK1 0.025 0.039 -10000 0 -0.31 6 6
mol:GDP 0.035 0.12 0.39 36 -0.27 3 39
mol:NADP 0.017 0.066 -10000 0 -0.44 11 11
RAB11A 0.025 0.006 -10000 0 -10000 0 0
PRKG1 0.003 0.1 -10000 0 -0.44 29 29
mol:IP3 -0.051 0.16 0.33 4 -0.39 77 81
cell morphogenesis 0.025 0.039 -10000 0 -0.31 6 6
PLCB2 -0.081 0.2 0.41 2 -0.53 76 78
mol:cGMP 0 0.001 -10000 0 -10000 0 0
BLK -0.041 0.089 0.32 2 -0.35 18 20
mol:PDG2 0 0 -10000 0 -10000 0 0
HCK -0.023 0.055 -10000 0 -0.33 7 7
RHOA 0.025 0.02 -10000 0 -0.44 1 1
PTGIR 0.024 0.046 -10000 0 -0.44 5 5
PRKCB1 -0.047 0.15 0.31 4 -0.37 75 79
GNAQ 0.022 0.044 -10000 0 -0.44 5 5
mol:L-citrulline 0.017 0.066 -10000 0 -0.44 11 11
TXA2/TXA2-R family -0.071 0.2 0.43 2 -0.53 71 73
LCK -0.032 0.078 0.26 3 -0.32 16 19
TXA2/TP beta/beta Arrestin3/RAB11/GDP -0.004 0.075 -10000 0 -0.22 42 42
TXA2-R family/G12 family/GDP/G beta/gamma -0.003 0.094 -10000 0 -0.41 24 24
TXA2/TP beta/beta Arrestin2/RAB11/GDP 0.003 0.073 -10000 0 -0.22 42 42
MAPK14 -0.029 0.095 0.31 5 -0.24 60 65
TGM2/GTP -0.063 0.16 0.3 2 -0.44 67 69
MAPK11 -0.03 0.094 0.25 5 -0.24 63 68
ARHGEF1 -0.025 0.071 -10000 0 -0.18 69 69
GNAI2 0.026 0.004 -10000 0 -10000 0 0
JNK cascade -0.049 0.15 0.33 4 -0.39 71 75
RAB11/GDP 0.025 0.006 -10000 0 -10000 0 0
ICAM1 -0.032 0.11 0.28 4 -0.29 62 66
cAMP biosynthetic process -0.051 0.15 0.32 4 -0.37 76 80
Gq family/GTP/EBP50 0.003 0.07 0.23 3 -0.25 29 32
actin cytoskeleton reorganization 0.025 0.039 -10000 0 -0.31 6 6
SRC -0.02 0.046 -10000 0 -0.31 4 4
GNB5 0.024 0.029 -10000 0 -0.44 2 2
GNB1 0.025 0.006 -10000 0 -10000 0 0
EGF/EGFR -0.021 0.11 0.19 20 -0.29 33 53
VCAM1 -0.038 0.12 0.29 4 -0.32 63 67
TP beta/Gq family/GDP/G beta5/gamma2 -0.022 0.13 -10000 0 -0.52 24 24
platelet activation -0.038 0.13 0.34 6 -0.3 73 79
PGI2/IP 0.018 0.033 -10000 0 -0.32 5 5
PRKACA -0.009 0.079 -10000 0 -0.25 48 48
Gq family/GDP/G beta5/gamma2 -0.02 0.12 -10000 0 -0.49 23 23
TXA2/TP beta/beta Arrestin2 -0.018 0.076 -10000 0 -0.4 11 11
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
TBXA2R -0.02 0.072 -10000 0 -0.24 48 48
mol:DAG -0.054 0.17 0.33 4 -0.42 74 78
EGFR 0.02 0.045 -10000 0 -0.44 5 5
TXA2/TP alpha -0.07 0.2 0.37 4 -0.5 76 80
Gq family/GTP -0.007 0.074 -10000 0 -0.24 39 39
YES1 -0.025 0.065 0.38 1 -0.37 6 7
GNAI2/GTP -0.008 0.075 -10000 0 -0.23 27 27
PGD2/DP -0.002 0.097 -10000 0 -0.32 47 47
SLC9A3R1 0.026 0.004 -10000 0 -10000 0 0
FYN -0.029 0.067 0.32 2 -0.35 6 8
mol:NO 0.017 0.066 -10000 0 -0.44 11 11
GNA15 0.015 0.074 -10000 0 -0.44 14 14
PGK/cGMP 0.013 0.079 -10000 0 -0.27 40 40
RhoA/GDP 0.025 0.02 -10000 0 -0.44 1 1
TP alpha/TGM2/GDP/G beta/gamma 0.009 0.073 -10000 0 -0.41 7 7
NOS3 0.017 0.066 -10000 0 -0.44 11 11
RAC1 0.024 0.008 -10000 0 -10000 0 0
PRKCA -0.043 0.14 0.32 5 -0.35 70 75
PRKCB -0.049 0.15 0.33 5 -0.38 72 77
PRKCE -0.041 0.14 0.29 3 -0.35 69 72
PRKCD -0.045 0.15 0.29 4 -0.38 71 75
PRKCG -0.059 0.16 0.33 4 -0.41 75 79
muscle contraction -0.069 0.19 0.37 4 -0.5 72 76
PRKCZ -0.045 0.13 0.31 4 -0.34 71 75
ARR3 -0.006 0.022 -10000 0 -10000 0 0
TXA2/TP beta 0.002 0.085 -10000 0 -0.22 55 55
PRKCQ -0.053 0.15 0.34 4 -0.38 73 77
MAPKKK cascade -0.064 0.18 0.34 4 -0.47 76 80
SELE -0.044 0.14 0.29 4 -0.39 61 65
TP beta/GNAI2/GDP/G beta/gamma 0.017 0.087 -10000 0 -0.5 4 4
ROCK1 0.017 0.049 -10000 0 -0.44 6 6
GNA14 0.014 0.076 -10000 0 -0.44 15 15
chemotaxis -0.078 0.22 0.43 2 -0.61 64 66
GNA12 0.024 0.008 -10000 0 -10000 0 0
GNA13 0.024 0.028 -10000 0 -0.44 2 2
GNA11 0.024 0.035 -10000 0 -0.44 3 3
Rac1/GTP 0.017 0.006 -10000 0 -10000 0 0
Nephrin/Neph1 signaling in the kidney podocyte

Figure S28.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S28.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
positive regulation of NF-kappaB transcription factor activity -0.008 0.12 0.35 49 -10000 0 49
KIRREL 0.001 0.1 -10000 0 -0.46 27 27
Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.008 0.12 -10000 0 -0.35 49 49
PLCG1 0.015 0.023 -10000 0 -0.44 1 1
ARRB2 0.022 0.01 -10000 0 -10000 0 0
WASL 0.026 0.005 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/CD2AP 0.02 0.12 -10000 0 -0.28 74 74
ChemicalAbstracts:57-88-5 0 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.002 0.084 -10000 0 -0.26 48 48
FYN -0.023 0.09 0.2 23 -0.25 51 74
mol:Ca2+ 0.017 0.085 -10000 0 -0.28 32 32
mol:DAG 0.018 0.086 -10000 0 -0.28 32 32
NPHS2 -0.004 0.037 -10000 0 -0.14 2 2
mol:IP3 0.018 0.086 -10000 0 -0.28 32 32
regulation of endocytosis 0.02 0.089 -10000 0 -0.24 51 51
Nephrin/NEPH1/podocin/Cholesterol 0.022 0.094 -10000 0 -0.27 48 48
establishment of cell polarity 0.008 0.12 -10000 0 -0.35 49 49
Nephrin/NEPH1/podocin/NCK1-2 0.048 0.1 -10000 0 -0.25 49 49
Nephrin/NEPH1/beta Arrestin2 0.021 0.09 -10000 0 -0.24 51 51
NPHS1 0.001 0.11 -10000 0 -0.45 28 28
Nephrin/NEPH1/podocin 0.023 0.093 -10000 0 -0.26 51 51
TJP1 0.024 0.021 -10000 0 -0.44 1 1
NCK1 0.025 0.028 -10000 0 -0.44 2 2
NCK2 0.026 0.02 -10000 0 -0.44 1 1
heterophilic cell adhesion 0 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/PLCgamma1 0.019 0.087 -10000 0 -0.28 32 32
CD2AP 0.004 0.1 -10000 0 -0.44 27 27
Nephrin/NEPH1/podocin/GRB2 0.036 0.1 -10000 0 -0.27 48 48
GRB2 0.026 0.004 -10000 0 -10000 0 0
homophilic cell adhesion 0 0 -10000 0 -10000 0 0
TRPC6 -0.036 0.1 0.22 22 -0.28 59 81
cytoskeleton organization -0.02 0.094 0.2 5 -0.31 46 51
Nephrin/NEPH1 0.011 0.083 -10000 0 -0.25 49 49
Nephrin/NEPH1/ZO-1 0.022 0.1 -10000 0 -0.29 49 49
p75(NTR)-mediated signaling

Figure S29.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S29.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Sortilin/TRAF6 0.037 0.023 -10000 0 -0.32 2 2
Necdin/E2F1 0.02 0.032 -10000 0 -0.32 3 3
proNGF (dimer)/p75(NTR)/Sortilin/NADE/14-3-3 E 0.022 0.12 -10000 0 -0.26 78 78
NGF (dimer)/p75(NTR)/BEX1 0.007 0.14 0.2 5 -0.3 83 88
NT-4/5 (dimer)/p75(NTR) 0.016 0.097 -10000 0 -0.32 40 40
IKBKB 0.023 0.009 -10000 0 -10000 0 0
AKT1 -0.044 0.074 0.17 6 -0.24 62 68
IKBKG 0.026 0.02 -10000 0 -0.44 1 1
BDNF 0.013 0.084 -10000 0 -0.44 18 18
MGDIs/NGR/p75(NTR)/LINGO1 0.032 0.095 0.2 1 -0.28 44 45
FURIN 0.025 0.021 -10000 0 -0.44 1 1
proBDNF (dimer)/p75(NTR)/Sortilin 0.023 0.11 -10000 0 -0.3 53 53
LINGO1 0.028 0.04 -10000 0 -0.44 3 3
Sortilin/TRAF6/NRIF 0.023 0.049 -10000 0 -0.25 14 14
proBDNF (dimer) 0.013 0.084 -10000 0 -0.44 18 18
NTRK1 0.001 0.11 -10000 0 -0.44 29 29
RTN4R 0.026 0.031 -10000 0 -0.44 2 2
neuron apoptosis -0.051 0.15 0.27 3 -0.46 37 40
IRAK1 0.026 0.02 -10000 0 -0.44 1 1
SHC1 -0.047 0.081 -10000 0 -0.28 58 58
ARHGDIA 0.024 0.028 -10000 0 -0.44 2 2
RhoA/GTP 0.019 0.014 -10000 0 -0.32 1 1
Gamma Secretase 0.065 0.041 -10000 0 -0.24 5 5
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-H1 0.032 0.11 -10000 0 -0.26 64 64
MAGEH1 0.021 0.052 -10000 0 -0.44 7 7
proNGF (dimer)/p75(NTR)/Sortilin/Necdin 0.03 0.11 -10000 0 -0.26 62 62
Mammalian IAPs/DIABLO 0.053 0.081 -10000 0 -0.35 19 19
proNGF (dimer) 0.007 0.091 -10000 0 -0.44 21 21
MAGED1 0.026 0.003 -10000 0 -10000 0 0
APP 0.024 0.021 -10000 0 -0.44 1 1
NT-4/5 (dimer) 0.001 0.034 -10000 0 -0.44 1 1
ZNF274 0.019 0.059 -10000 0 -0.44 9 9
RhoA/GDP/RHOGDI -0.006 0.087 -10000 0 -0.24 62 62
NGF 0.007 0.091 -10000 0 -0.44 21 21
cell cycle arrest -0.041 0.073 0.2 7 -0.21 59 66
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK -0.004 0.08 -10000 0 -0.24 54 54
NT-4/5 (dimer)/p75(NTR)/TRAF6 0.03 0.089 -10000 0 -0.28 41 41
NCSTN 0.026 0.004 -10000 0 -10000 0 0
mol:GTP 0.006 0.13 -10000 0 -0.29 81 81
PSENEN 0.025 0.02 -10000 0 -0.44 1 1
mol:ceramide -0.044 0.078 0.18 6 -0.26 59 65
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs -0.009 0.077 -10000 0 -0.37 8 8
p75(NTR)/beta APP 0.016 0.096 -10000 0 -0.32 41 41
BEX1 -0.001 0.11 -10000 0 -0.44 30 30
mol:GDP -0.043 0.082 -10000 0 -0.27 60 60
NGF (dimer) -0.007 0.14 -10000 0 -0.28 118 118
MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI 0.044 0.097 -10000 0 -0.26 45 45
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
RAC1/GTP 0.016 0.089 -10000 0 -0.23 59 59
MYD88 0.026 0.003 -10000 0 -10000 0 0
CHUK 0.023 0.035 -10000 0 -0.44 3 3
NGF (dimer)/p75(NTR)/PKA 0.006 0.13 -10000 0 -0.29 81 81
RHOB 0.025 0.028 -10000 0 -0.44 2 2
RHOA 0.025 0.02 -10000 0 -0.44 1 1
MAGE-G1/E2F1 0.021 0.024 -10000 0 -0.32 1 1
NT3 (dimer) 0.008 0.09 -10000 0 -0.44 21 21
TP53 -0.055 0.098 0.23 8 -0.26 79 87
PRDM4 -0.044 0.079 0.18 7 -0.26 59 66
BDNF (dimer) -0.043 0.18 -10000 0 -0.3 175 175
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
SORT1 0.025 0.02 -10000 0 -0.44 1 1
activation of caspase activity 0.017 0.12 -10000 0 -0.26 78 78
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 0.034 0.11 -10000 0 -0.26 60 60
RHOC 0.026 0.005 -10000 0 -10000 0 0
XIAP 0.026 0.02 -10000 0 -0.44 1 1
MAPK10 -0.041 0.12 0.31 6 -0.34 50 56
DIABLO 0.026 0.003 -10000 0 -10000 0 0
SMPD2 -0.044 0.079 0.18 6 -0.26 59 65
APH1B 0.022 0.04 -10000 0 -0.44 4 4
APH1A 0.026 0.004 -10000 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin 0.021 0.11 -10000 0 -0.28 61 61
PSEN1 0.025 0.007 -10000 0 -10000 0 0
APAF-1/Pro-Caspase 9 0.035 0.031 -10000 0 -0.32 4 4
NT3 (dimer)/p75(NTR) 0.006 0.12 -10000 0 -0.35 54 54
MAPK8 -0.031 0.11 0.31 6 -0.32 44 50
MAPK9 -0.031 0.11 0.32 5 -0.32 44 49
APAF1 0.024 0.034 -10000 0 -0.44 3 3
NTF3 0.008 0.09 -10000 0 -0.44 21 21
NTF4 0.001 0.034 -10000 0 -0.44 1 1
NDN 0.022 0.041 -10000 0 -0.44 4 4
RAC1/GDP 0.018 0.006 -10000 0 -10000 0 0
RhoA-B-C/GDP 0.024 0.12 -10000 0 -0.24 83 83
p75 CTF/Sortilin/TRAF6/NRIF 0.057 0.055 -10000 0 -0.29 11 11
RhoA-B-C/GTP 0.005 0.13 -10000 0 -0.29 81 81
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.042 0.11 -10000 0 -0.27 59 59
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 0.037 0.11 -10000 0 -0.28 54 54
PRKACB 0.003 0.1 -10000 0 -0.44 28 28
proBDNF (dimer)/p75 ECD 0.028 0.068 -10000 0 -0.32 20 20
ChemicalAbstracts:86-01-1 0 0 -10000 0 -10000 0 0
BIRC3 0.016 0.074 -10000 0 -0.44 14 14
BIRC2 0.015 0.071 -10000 0 -0.44 13 13
neuron projection morphogenesis -0.043 0.094 0.13 19 -0.26 76 95
BAD -0.037 0.12 0.3 9 -0.34 44 53
RIPK2 0.023 0.009 -10000 0 -10000 0 0
NGFR 0 0.12 -10000 0 -0.44 40 40
CYCS -0.047 0.08 0.17 5 -0.25 69 74
ADAM17 0.025 0.028 -10000 0 -0.44 2 2
NGF (dimer)/p75(NTR)/TRAF6/RIP2 0.03 0.098 -10000 0 -0.26 51 51
BCL2L11 -0.037 0.12 0.3 9 -0.34 44 53
BDNF (dimer)/p75(NTR) 0.008 0.12 -10000 0 -0.34 53 53
PI3K 0.032 0.1 -10000 0 -0.25 62 62
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-G1 0.033 0.1 -10000 0 -0.26 59 59
NDNL2 0.025 0.007 -10000 0 -10000 0 0
YWHAE 0.022 0.01 -10000 0 -10000 0 0
PRKCI 0.024 0.034 -10000 0 -0.44 3 3
NGF (dimer)/p75(NTR) 0.005 0.12 -10000 0 -0.32 61 61
ChemicalAbstracts:146-91-8 0 0 -10000 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/NRAGE 0.036 0.1 -10000 0 -0.26 57 57
TRAF6 0.025 0.02 -10000 0 -0.44 1 1
RAC1 0.024 0.008 -10000 0 -10000 0 0
PRKCZ 0.025 0.021 -10000 0 -0.44 1 1
PLG -0.028 0.11 -10000 0 -0.44 37 37
oligodendrocyte cell fate commitment 0 0 -10000 0 -10000 0 0
CASP6 -0.028 0.1 -10000 0 -0.28 71 71
SQSTM1 0.026 0.004 -10000 0 -10000 0 0
NGFRAP1 0.002 0.1 -10000 0 -0.44 29 29
CASP3 -0.037 0.12 0.32 7 -0.32 48 55
E2F1 0.015 0.023 -10000 0 -0.44 1 1
CASP9 0.024 0.021 -10000 0 -0.44 1 1
IKK complex 0.008 0.12 -10000 0 -0.33 31 31
NGF (dimer)/TRKA 0.008 0.11 -10000 0 -0.32 50 50
MMP7 -0.025 0.16 -10000 0 -0.44 73 73
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.04 0.11 -10000 0 -0.26 63 63
MMP3 -0.038 0.17 -10000 0 -0.44 85 85
APAF-1/Caspase 9 -0.063 0.092 -10000 0 -0.42 19 19
Glucocorticoid receptor regulatory network

Figure S30.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S30.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PCK2 0.044 0.077 0.3 9 -10000 0 9
SMARCC2 0.027 0.007 -10000 0 -10000 0 0
SMARCC1 0.027 0.009 -10000 0 -10000 0 0
TBX21 -0.077 0.21 0.34 5 -0.72 45 50
SUMO2 0.025 0.022 -10000 0 -0.44 1 1
STAT1 (dimer) 0.03 0.029 -10000 0 -0.44 2 2
FKBP4 0.026 0.006 -10000 0 -10000 0 0
FKBP5 0.025 0.028 -10000 0 -0.44 2 2
GR alpha/HSP90/FKBP51/HSP90 0.076 0.098 0.29 43 -0.29 7 50
PRL -0.038 0.096 -10000 0 -10000 0 0
cortisol/GR alpha (dimer)/TIF2 0.09 0.2 0.52 55 -0.45 2 57
RELA -0.008 0.095 -10000 0 -0.26 39 39
FGG 0.074 0.17 0.44 58 -10000 0 58
GR beta/TIF2 0.042 0.11 0.27 50 -0.33 9 59
IFNG -0.17 0.34 -10000 0 -0.95 67 67
apoptosis 0.014 0.13 0.48 16 -0.47 8 24
CREB1 0.027 0.028 -10000 0 -0.44 2 2
histone acetylation -0.03 0.1 0.31 3 -0.36 25 28
BGLAP -0.04 0.12 -10000 0 -0.54 13 13
GR/PKAc 0.079 0.11 0.3 27 -0.27 20 47
NF kappa B1 p50/RelA -0.02 0.18 -10000 0 -0.36 100 100
SMARCD1 0.026 0.021 -10000 0 -0.44 1 1
MDM2 0.046 0.079 0.22 62 -0.26 2 64
GATA3 0.018 0.08 -10000 0 -0.44 16 16
AKT1 0.021 0.021 -10000 0 -0.45 1 1
CSF2 -0.15 0.36 -10000 0 -1.2 59 59
GSK3B 0.024 0.029 -10000 0 -0.44 2 2
NR1I3 0.008 0.16 0.46 15 -0.82 10 25
CSN2 0.061 0.14 0.37 52 -10000 0 52
BRG1/BAF155/BAF170/BAF60A 0.068 0.032 -10000 0 -0.24 5 5
NFATC1 0.015 0.061 -10000 0 -0.44 9 9
POU2F1 0.022 0.053 -10000 0 -0.44 7 7
CDKN1A -0.045 0.15 -10000 0 -1.5 3 3
response to stress 0 0 -10000 0 -10000 0 0
response to UV 0 0.006 -10000 0 -10000 0 0
SFN 0.025 0.023 -10000 0 -0.44 1 1
GR alpha/HSP90/FKBP51/HSP90/14-3-3 0.087 0.09 0.3 33 -0.28 7 40
prolactin receptor activity 0 0 -10000 0 -10000 0 0
EGR1 0.005 0.15 0.43 15 -0.78 9 24
JUN -0.098 0.16 0.28 1 -0.42 66 67
IL4 -0.042 0.12 -10000 0 -0.52 16 16
CDK5R1 0.026 0.008 -10000 0 -10000 0 0
PRKACA 0.026 0.003 -10000 0 -10000 0 0
cortisol/GR alpha (monomer)/AP-1 -0.064 0.14 0.2 51 -0.34 54 105
GR alpha/HSP90/FKBP51/HSP90/PP5C 0.092 0.09 0.3 35 -0.28 6 41
cortisol/GR alpha (monomer) 0.12 0.24 0.62 68 -10000 0 68
NCOA2 0.018 0.049 -10000 0 -0.44 6 6
response to hypoxia 0 0 -10000 0 -10000 0 0
FOS -0.029 0.11 -10000 0 -0.32 36 36
AP-1/NFAT1-c-4 -0.16 0.27 -10000 0 -0.54 148 148
AFP -0.082 0.14 -10000 0 -0.9 3 3
SUV420H1 0.025 0.02 -10000 0 -0.44 1 1
IRF1 0.073 0.12 0.4 32 -0.49 1 33
TP53 -0.001 0.12 -10000 0 -0.44 37 37
PPP5C 0.026 0.004 -10000 0 -10000 0 0
KRT17 -0.23 0.41 -10000 0 -1 102 102
KRT14 -0.066 0.17 -10000 0 -1 11 11
TBP 0.03 0.024 -10000 0 -0.37 2 2
CREBBP 0.037 0.044 0.31 6 -0.27 3 9
HDAC1 0.025 0.005 -10000 0 -10000 0 0
HDAC2 0.033 0.025 0.15 1 -10000 0 1
AP-1 -0.16 0.27 -10000 0 -0.54 149 149
MAPK14 0.026 0.01 -10000 0 -10000 0 0
MAPK10 0.003 0.1 -10000 0 -0.44 28 28
MAPK11 0.024 0.038 -10000 0 -0.44 3 3
KRT5 -0.2 0.38 -10000 0 -0.98 87 87
interleukin-1 receptor activity 0.008 0.025 -10000 0 -10000 0 0
NCOA1 0.027 0.02 -10000 0 -0.44 1 1
STAT1 0.03 0.029 -10000 0 -0.44 2 2
CGA -0.045 0.11 -10000 0 -0.48 9 9
NF kappa B1 p50/RelA/Cbp/cortisol/GR alpha (monomer)/HDAC2 0.067 0.18 0.48 65 -0.43 9 74
MAPK3 0.025 0.022 -10000 0 -0.44 1 1
MAPK1 0.025 0.011 -10000 0 -10000 0 0
ICAM1 -0.084 0.2 -10000 0 -0.55 58 58
NFKB1 -0.009 0.099 -10000 0 -0.21 94 94
MAPK8 -0.074 0.14 0.34 1 -0.38 60 61
MAPK9 0.026 0.01 -10000 0 -10000 0 0
cortisol/GR alpha (dimer) 0.012 0.14 0.48 16 -0.48 9 25
BAX -0.039 0.12 -10000 0 -0.98 2 2
POMC -0.092 0.28 -10000 0 -1.5 18 18
EP300 0.036 0.055 0.32 7 -0.34 5 12
cortisol/GR alpha (dimer)/p53 0.071 0.2 0.55 48 -10000 0 48
proteasomal ubiquitin-dependent protein catabolic process 0.028 0.073 0.22 41 -0.23 2 43
SGK1 0.029 0.13 -10000 0 -1 5 5
IL13 -0.11 0.2 -10000 0 -0.68 29 29
IL6 -0.14 0.34 -10000 0 -0.95 75 75
PRKACG -0.005 0.021 -10000 0 -10000 0 0
IL5 -0.093 0.16 -10000 0 -0.55 27 27
IL2 -0.13 0.23 -10000 0 -0.68 48 48
CDK5 0.026 0.006 -10000 0 -10000 0 0
PRKACB 0.003 0.1 -10000 0 -0.44 28 28
HSP90AA1 0.024 0.021 -10000 0 -0.44 1 1
IL8 -0.16 0.36 -10000 0 -0.9 90 90
CDK5R1/CDK5 0.037 0.013 -10000 0 -10000 0 0
NF kappa B1 p50/RelA/PKAc 0.005 0.17 -10000 0 -0.36 65 65
cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 0.1 0.2 0.52 66 -10000 0 66
SMARCA4 0.026 0.021 -10000 0 -0.44 1 1
chromatin remodeling 0.073 0.13 0.35 55 -0.38 4 59
NF kappa B1 p50/RelA/Cbp 0.021 0.17 0.31 23 -0.44 37 60
JUN (dimer) -0.098 0.16 0.28 1 -0.42 66 67
YWHAH 0.026 0.005 -10000 0 -10000 0 0
VIPR1 -0.069 0.18 -10000 0 -0.64 38 38
NR3C1 0.069 0.16 0.4 64 -0.37 6 70
NR4A1 0.019 0.091 -10000 0 -0.46 18 18
TIF2/SUV420H1 0.03 0.039 -10000 0 -0.32 6 6
MAPKKK cascade 0.014 0.13 0.48 16 -0.47 8 24
cortisol/GR alpha (dimer)/Src-1 0.12 0.21 0.53 71 -0.36 1 72
PBX1 0.017 0.071 -10000 0 -0.44 13 13
POU1F1 0.004 0.021 -10000 0 -10000 0 0
SELE -0.14 0.34 -10000 0 -0.92 75 75
cortisol/GR alpha/BRG1/BAF155/BAF170/BAF60A 0.073 0.13 0.35 54 -0.38 4 58
cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 0.1 0.2 0.52 66 -10000 0 66
mol:cortisol 0.068 0.14 0.37 70 -10000 0 70
MMP1 -0.19 0.42 -10000 0 -1.1 90 90
Signaling events regulated by Ret tyrosine kinase

Figure S31.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S31.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 0.001 0.07 -10000 0 -0.4 13 13
Crk/p130 Cas/Paxillin -0.029 0.096 -10000 0 -0.3 43 43
JUN -0.028 0.095 -10000 0 -0.25 70 70
HRAS 0.026 0.021 -10000 0 -0.44 1 1
RET51/GFRalpha1/GDNF/GRB10 0.021 0.13 -10000 0 -0.3 66 66
RAP1A 0.025 0.02 -10000 0 -0.44 1 1
FRS2 0.025 0.028 -10000 0 -0.44 2 2
RAP1A/GDP 0.018 0.015 -10000 0 -0.32 1 1
RET51/GFRalpha1/GDNF/DOK1 0.027 0.12 0.21 1 -0.29 68 69
EntrezGene:5979 0 0 -10000 0 -10000 0 0
PTPN11 0.022 0.044 -10000 0 -0.44 5 5
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.022 0.011 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/Enigma 0.025 0.086 0.19 1 -0.25 46 47
RHOA 0.025 0.02 -10000 0 -0.44 1 1
RAP1A/GTP 0.023 0.11 -10000 0 -0.27 68 68
GRB7 0.025 0.006 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF 0.027 0.12 0.21 1 -0.29 68 69
MAPKKK cascade -0.002 0.11 -10000 0 -0.29 63 63
BCAR1 0.025 0.029 -10000 0 -0.44 2 2
RET9/GFRalpha1/GDNF/IRS1 0.022 0.092 -10000 0 -0.26 53 53
lamellipodium assembly -0.021 0.09 -10000 0 -0.28 44 44
RET51/GFRalpha1/GDNF/SHC 0.026 0.12 0.21 1 -0.29 68 69
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
RET9/GFRalpha1/GDNF/SHC 0.025 0.084 -10000 0 -0.25 46 46
RET9/GFRalpha1/GDNF/Shank3 0.024 0.085 -10000 0 -0.25 46 46
MAPK3 -0.049 0.088 0.17 10 -0.26 67 77
DOK1 0.027 0.001 -10000 0 -10000 0 0
DOK6 0.007 0.079 -10000 0 -0.44 16 16
PXN 0.027 0.002 -10000 0 -10000 0 0
neurite development -0.037 0.083 -10000 0 -0.34 23 23
DOK5 -0.005 0.099 -10000 0 -0.44 26 26
GFRA1 -0.008 0.13 -10000 0 -0.44 45 45
MAPK8 -0.022 0.096 -10000 0 -0.26 70 70
HRAS/GTP 0.018 0.13 -10000 0 -0.31 66 66
tube development 0.023 0.082 0.2 6 -0.24 46 52
MAPK1 -0.048 0.088 0.18 11 -0.26 65 76
RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.003 0.077 -10000 0 -0.24 52 52
Rac1/GDP 0.018 0.006 -10000 0 -10000 0 0
SRC 0.015 0.023 -10000 0 -0.44 1 1
PDLIM7 0.026 0.022 -10000 0 -0.44 1 1
RET51/GFRalpha1/GDNF/Dok6 0.002 0.11 0.25 1 -0.29 55 56
SHC1 0.026 0.004 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/Dok4 0.027 0.12 0.21 1 -0.3 67 68
RET51/GFRalpha1/GDNF/Dok5 -0.002 0.12 0.23 3 -0.31 64 67
PRKCA 0.025 0.02 -10000 0 -0.44 1 1
HRAS/GDP 0.019 0.015 -10000 0 -0.32 1 1
CREB1 -0.009 0.097 -10000 0 -0.3 46 46
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.001 0.073 -10000 0 -0.24 46 46
RET51/GFRalpha1/GDNF/Grb7 0.027 0.12 0.21 1 -0.29 62 63
mol:GDP 0 0 -10000 0 -10000 0 0
RET 0.005 0.12 -10000 0 -0.44 35 35
DOK4 0.026 0.02 -10000 0 -0.44 1 1
JNK cascade -0.027 0.094 -10000 0 -0.28 45 45
RET9/GFRalpha1/GDNF/FRS2 0.025 0.085 -10000 0 -0.25 48 48
SHANK3 0.025 0.021 -10000 0 -0.44 1 1
RASA1 0.024 0.028 -10000 0 -0.44 2 2
NCK1 0.025 0.028 -10000 0 -0.44 2 2
RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.001 0.07 -10000 0 -0.23 46 46
RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.015 0.11 -10000 0 -0.27 72 72
RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK -0.013 0.1 -10000 0 -0.26 72 72
RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.012 0.11 -10000 0 -0.28 65 65
PI3K -0.033 0.13 -10000 0 -0.4 46 46
SOS1 0.027 0.002 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/Shank3/Grb2 0.034 0.085 -10000 0 -0.24 46 46
GRB10 0.021 0.04 -10000 0 -0.44 4 4
activation of MAPKK activity -0.011 0.094 -10000 0 -0.26 51 51
RET51/GFRalpha1/GDNF/FRS2 0.026 0.12 0.21 1 -0.29 70 71
GAB1 0.026 0.005 -10000 0 -10000 0 0
IRS1 0.019 0.059 -10000 0 -0.44 9 9
IRS2 0.015 0.049 -10000 0 -0.44 6 6
RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.012 0.11 -10000 0 -0.29 65 65
RET51/GFRalpha1/GDNF/PKC alpha 0.027 0.12 -10000 0 -0.29 64 64
GRB2 0.026 0.004 -10000 0 -10000 0 0
PRKACA 0.026 0.003 -10000 0 -10000 0 0
GDNF 0.015 0.028 -10000 0 -0.44 1 1
RAC1 0.024 0.008 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/IRS1 0.023 0.13 0.21 1 -0.31 71 72
Rac1/GTP -0.022 0.11 -10000 0 -0.33 44 44
RET9/GFRalpha1/GDNF 0.011 0.086 -10000 0 -0.27 46 46
GFRalpha1/GDNF 0.01 0.1 -10000 0 -0.32 46 46
Signaling events mediated by Stem cell factor receptor (c-Kit)

Figure S32.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S32.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAP4K1 -0.033 0.12 -10000 0 -0.38 42 42
CRKL -0.019 0.11 -10000 0 -0.39 41 41
HRAS -0.018 0.13 -10000 0 -0.39 45 45
mol:PIP3 -0.009 0.11 0.26 2 -0.37 38 40
SPRED1 0.021 0.045 -10000 0 -0.44 5 5
SPRED2 0.024 0.034 -10000 0 -0.44 3 3
GAB1 -0.016 0.12 -10000 0 -0.39 43 43
FOXO3 -0.019 0.14 0.25 1 -0.4 53 54
AKT1 -0.019 0.16 0.26 1 -0.42 57 58
BAD -0.02 0.15 0.25 1 -0.41 53 54
megakaryocyte differentiation -0.055 0.14 -10000 0 -0.42 48 48
GSK3B -0.019 0.15 0.31 2 -0.4 54 56
RAF1 -0.02 0.11 0.23 1 -0.32 43 44
SHC1 0.026 0.004 -10000 0 -10000 0 0
STAT3 -0.017 0.12 -10000 0 -0.39 43 43
STAT1 -0.054 0.3 -10000 0 -0.99 45 45
HRAS/SPRED1 -0.005 0.12 -10000 0 -0.33 46 46
cell proliferation -0.016 0.11 -10000 0 -0.38 43 43
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
TEC 0.026 0.004 -10000 0 -10000 0 0
RPS6KB1 -0.013 0.14 -10000 0 -0.44 42 42
HRAS/SPRED2 -0.005 0.12 -10000 0 -0.32 45 45
LYN/TEC/p62DOK 0.022 0.12 -10000 0 -0.37 36 36
MAPK3 -0.014 0.08 0.19 2 -0.25 28 30
STAP1 -0.03 0.13 -10000 0 -0.44 44 44
GRAP2 0.009 0.09 -10000 0 -0.44 21 21
JAK2 -0.045 0.27 -10000 0 -0.88 45 45
STAT1 (dimer) -0.051 0.28 -10000 0 -0.96 45 45
mol:Gleevec 0 0.004 -10000 0 -10000 0 0
GRB2/SOCS1/VAV1 0.007 0.15 -10000 0 -0.4 48 48
actin filament polymerization -0.021 0.11 0.22 1 -0.37 43 44
LYN 0.023 0.009 -10000 0 -10000 0 0
STAP1/STAT5A (dimer) -0.04 0.18 -10000 0 -0.61 46 46
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
CBL/CRKL/GRB2 0.007 0.11 -10000 0 -0.37 38 38
PI3K 0.01 0.14 -10000 0 -0.42 43 43
PTEN 0.025 0.006 -10000 0 -10000 0 0
SCF/KIT/EPO/EPOR -0.035 0.32 -10000 0 -1.2 34 34
MAPK8 -0.017 0.11 -10000 0 -0.39 43 43
STAT3 (dimer) -0.016 0.11 -10000 0 -0.38 43 43
positive regulation of transcription -0.01 0.067 0.18 2 -0.21 25 27
mol:GDP -0.013 0.14 -10000 0 -0.39 50 50
PIK3C2B -0.016 0.11 -10000 0 -0.39 42 42
CBL/CRKL -0.004 0.11 -10000 0 -0.38 38 38
FER -0.018 0.12 -10000 0 -0.4 44 44
SH2B3 -0.017 0.12 -10000 0 -0.39 43 43
PDPK1 -0.008 0.1 0.24 3 -0.35 34 37
SNAI2 -0.018 0.11 -10000 0 -0.38 42 42
positive regulation of cell proliferation -0.033 0.21 -10000 0 -0.7 45 45
KITLG 0.012 0.081 -10000 0 -0.46 15 15
cell motility -0.033 0.21 -10000 0 -0.7 45 45
PTPN6 0.026 0.008 -10000 0 -10000 0 0
EPOR 0.008 0.13 -10000 0 -1.2 3 3
STAT5A (dimer) -0.024 0.17 -10000 0 -0.57 45 45
SOCS1 0.021 0.068 -10000 0 -0.44 11 11
cell migration 0.033 0.13 0.41 45 -10000 0 45
SOS1 0.027 0.002 -10000 0 -10000 0 0
EPO 0.019 0.019 -10000 0 -10000 0 0
VAV1 -0.001 0.11 -10000 0 -0.44 33 33
GRB10 -0.018 0.11 -10000 0 -0.38 44 44
PTPN11 0.022 0.044 -10000 0 -0.44 5 5
SCF/KIT -0.013 0.12 -10000 0 -0.41 43 43
GO:0007205 0.001 0.006 -10000 0 -10000 0 0
MAP2K1 -0.018 0.086 0.2 2 -0.26 42 44
CBL 0.026 0.004 -10000 0 -10000 0 0
KIT -0.05 0.31 -10000 0 -1.1 39 39
MAP2K2 -0.018 0.086 0.2 2 -0.27 40 42
SHC/Grb2/SOS1 0.023 0.12 -10000 0 -0.4 37 37
STAT5A -0.025 0.18 -10000 0 -0.58 46 46
GRB2 0.026 0.004 -10000 0 -10000 0 0
response to radiation -0.017 0.11 -10000 0 -0.37 42 42
SHC/GRAP2 0.024 0.069 -10000 0 -0.32 21 21
PTPRO -0.056 0.14 -10000 0 -0.43 48 48
SH2B2 -0.021 0.11 0.22 1 -0.38 43 44
DOK1 0.027 0.001 -10000 0 -10000 0 0
MATK -0.034 0.13 -10000 0 -0.42 45 45
CREBBP 0.028 0.037 -10000 0 -0.18 3 3
BCL2 -0.14 0.34 -10000 0 -1.1 42 42
JNK signaling in the CD4+ TCR pathway

Figure S33.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S33.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
LAT/GRAP2/SLP76/HPK1 0.022 0.14 0.25 1 -0.36 58 59
MAP4K1 -0.007 0.12 -10000 0 -0.44 42 42
MAP3K8 0.026 0.02 -10000 0 -0.44 1 1
PRKCB 0 0.11 -10000 0 -0.44 34 34
DBNL 0.023 0.021 -10000 0 -0.44 1 1
CRKL 0.026 0.005 -10000 0 -10000 0 0
MAP3K1 -0.027 0.13 -10000 0 -0.4 47 47
JUN -0.043 0.21 -10000 0 -0.69 50 50
MAP3K7 -0.026 0.13 -10000 0 -0.44 39 39
GRAP2 0.009 0.09 -10000 0 -0.44 21 21
CRK 0.022 0.011 -10000 0 -10000 0 0
MAP2K4 -0.034 0.14 0.39 1 -0.47 39 40
LAT 0.019 0.063 -10000 0 -0.44 10 10
LCP2 0.013 0.081 -10000 0 -0.44 17 17
MAPK8 -0.039 0.22 -10000 0 -0.71 50 50
LAT/GRAP2/SLP76/HPK1/HIP-55/CRK family -0.021 0.14 -10000 0 -0.42 45 45
LAT/GRAP2/SLP76/HPK1/HIP-55 0.029 0.13 0.25 1 -0.34 54 55
EPHB forward signaling

Figure S34.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S34.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Ephrin A5/EPHB2 0.003 0.097 -10000 0 -0.27 61 61
cell-cell adhesion 0.037 0.061 0.23 43 -10000 0 43
Ephrin B/EPHB2/RasGAP 0.038 0.07 -10000 0 -0.26 18 18
ITSN1 0.025 0.02 -10000 0 -0.44 1 1
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
SHC1 0.026 0.004 -10000 0 -10000 0 0
Ephrin B1/EPHB3 0.025 0.06 -10000 0 -0.28 20 20
Ephrin B1/EPHB1 0.023 0.08 -10000 0 -0.27 37 37
HRAS/GDP -0.006 0.093 -10000 0 -0.29 22 22
Ephrin B/EPHB1/GRB7 0.032 0.09 -10000 0 -0.25 38 38
Endophilin/SYNJ1 0.018 0.09 0.17 114 -0.25 17 131
KRAS 0.022 0.044 -10000 0 -0.44 5 5
Ephrin B/EPHB1/Src 0.02 0.082 -10000 0 -0.26 31 31
endothelial cell migration 0.038 0.039 -10000 0 -0.28 4 4
GRB2 0.026 0.004 -10000 0 -10000 0 0
GRB7 0.025 0.006 -10000 0 -10000 0 0
PAK1 0.017 0.1 0.24 6 -0.29 17 23
HRAS 0.026 0.021 -10000 0 -0.44 1 1
RRAS 0.02 0.094 0.18 118 -0.27 16 134
DNM1 0.023 0.045 -10000 0 -0.44 5 5
cell-cell signaling 0 0 -10000 0 -10000 0 0
CRK -0.003 0.097 0.18 74 -0.24 32 106
lamellipodium assembly -0.037 0.061 -10000 0 -0.23 43 43
Ephrin B/EPHB1/Src/p52 SHC/GRB2 0.009 0.084 0.21 1 -0.26 29 30
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
EPHB2 0.018 0.059 -10000 0 -0.44 9 9
EPHB3 0.011 0.088 -10000 0 -0.44 20 20
EPHB1 0.008 0.12 -10000 0 -0.44 36 36
EPHB4 0.025 0.006 -10000 0 -10000 0 0
mol:GDP -0.004 0.085 0.32 5 -0.3 17 22
Ephrin B/EPHB2 0.03 0.062 -10000 0 -0.26 16 16
Ephrin B/EPHB3 0.028 0.072 -10000 0 -0.26 24 24
JNK cascade -0.04 0.071 0.35 4 -0.24 47 51
Ephrin B/EPHB1 0.023 0.084 -10000 0 -0.24 40 40
RAP1/GDP 0.006 0.11 0.31 19 -0.29 17 36
EFNB2 0.02 0.023 -10000 0 -0.44 1 1
EFNB3 0.015 0.067 -10000 0 -0.44 11 11
EFNB1 0.026 0.02 -10000 0 -0.44 1 1
Ephrin B2/EPHB1-2 0.02 0.083 -10000 0 -0.25 42 42
RAP1B 0.027 0.002 -10000 0 -10000 0 0
RAP1A 0.025 0.02 -10000 0 -0.44 1 1
CDC42/GTP 0.001 0.096 -10000 0 -0.3 28 28
Rap1/GTP -0.015 0.074 -10000 0 -0.24 35 35
axon guidance 0.003 0.096 -10000 0 -0.27 61 61
MAPK3 0.004 0.079 0.18 3 -0.33 10 13
MAPK1 0.004 0.078 0.18 1 -0.33 10 11
Rac1/GDP -0.01 0.091 0.24 3 -0.29 15 18
actin cytoskeleton reorganization -0.047 0.066 -10000 0 -0.27 24 24
CDC42/GDP 0 0.11 0.32 20 -0.31 18 38
PI3K 0.042 0.041 -10000 0 -0.29 4 4
EFNA5 -0.01 0.14 -10000 0 -0.44 51 51
Ephrin B2/EPHB4 0.027 0.02 -10000 0 -0.27 1 1
Ephrin B/EPHB2/Intersectin/N-WASP 0.003 0.059 -10000 0 -0.26 16 16
CDC42 0.022 0.04 -10000 0 -0.44 4 4
RAS family/GTP -0.045 0.072 -10000 0 -0.25 44 44
PTK2 0.081 0.21 0.56 87 -0.44 1 88
MAP4K4 -0.04 0.072 0.35 4 -0.24 47 51
SRC 0.015 0.023 -10000 0 -0.44 1 1
KALRN 0.022 0.044 -10000 0 -0.44 5 5
Intersectin/N-WASP 0.036 0.018 -10000 0 -0.32 1 1
neuron projection morphogenesis -0.018 0.1 0.27 20 -0.39 8 28
MAP2K1 0.004 0.078 0.19 1 -0.35 10 11
WASL 0.026 0.005 -10000 0 -10000 0 0
Ephrin B1/EPHB1-2/NCK1 0.045 0.095 -10000 0 -0.26 46 46
cell migration 0.03 0.12 0.26 21 -0.38 11 32
NRAS 0.018 0.059 -10000 0 -0.44 9 9
SYNJ1 0.019 0.091 0.18 114 -0.25 17 131
PXN 0.027 0.002 -10000 0 -10000 0 0
TF -0.001 0.1 0.16 105 -0.24 38 143
HRAS/GTP 0.009 0.085 -10000 0 -0.24 47 47
Ephrin B1/EPHB1-2 0.032 0.087 -10000 0 -0.25 44 44
cell adhesion mediated by integrin -0.026 0.093 0.27 9 -0.19 113 122
RAC1 0.024 0.008 -10000 0 -10000 0 0
mol:GTP 0.011 0.086 -10000 0 -0.24 48 48
RAC1-CDC42/GTP -0.047 0.077 -10000 0 -0.26 48 48
RASA1 0.024 0.028 -10000 0 -0.44 2 2
RAC1-CDC42/GDP -0.004 0.095 0.24 3 -0.3 17 20
ruffle organization 0.006 0.13 0.39 32 -0.37 6 38
NCK1 0.025 0.028 -10000 0 -0.44 2 2
receptor internalization 0.013 0.09 0.17 112 -0.24 20 132
Ephrin B/EPHB2/KALRN 0.037 0.076 -10000 0 -0.3 18 18
ROCK1 -0.021 0.055 0.18 1 -0.26 25 26
RAS family/GDP -0.046 0.066 -10000 0 -0.27 24 24
Rac1/GTP -0.038 0.064 -10000 0 -0.24 43 43
Ephrin B/EPHB1/Src/Paxillin 0.001 0.07 -10000 0 -0.26 31 31
Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Figure S35.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S35.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
FOXP3 -0.012 0.14 -10000 0 -0.43 50 50
NFATC2 -0.028 0.16 -10000 0 -0.52 33 33
NFATC3 0.001 0.078 0.2 1 -0.24 29 30
CD40LG -0.12 0.32 -10000 0 -0.8 72 72
ITCH 0.007 0.058 -10000 0 -0.33 13 13
CBLB 0.016 0.065 -10000 0 -0.76 3 3
CD4-positive CD25-positive alpha-beta regulatory T cell lineage commitment -0.16 0.38 -10000 0 -1.1 67 67
JUNB 0.024 0.035 -10000 0 -0.44 3 3
CaM/Ca2+/Calcineurin A alpha-beta B1 0.025 0.061 -10000 0 -0.34 13 13
T cell anergy 0.004 0.087 -10000 0 -0.45 13 13
TLE4 -0.025 0.13 -10000 0 -0.49 24 24
Jun/NFAT1-c-4/p21SNFT -0.068 0.25 -10000 0 -0.78 41 41
AP-1/NFAT1-c-4 -0.12 0.33 -10000 0 -0.87 63 63
IKZF1 -0.025 0.14 -10000 0 -0.57 19 19
T-helper 2 cell differentiation -0.069 0.23 -10000 0 -0.79 33 33
AP-1/NFAT1 -0.022 0.14 -10000 0 -0.41 32 32
CALM1 0.027 0.036 -10000 0 -0.31 3 3
EGR2 -0.072 0.26 -10000 0 -1 28 28
EGR3 -0.074 0.26 -10000 0 -1 32 32
NFAT1/FOXP3 -0.028 0.17 -10000 0 -0.54 37 37
EGR1 0.02 0.059 -10000 0 -0.41 9 9
JUN -0.002 0.057 -10000 0 -0.47 4 4
EGR4 0.004 0.11 -10000 0 -0.44 29 29
mol:Ca2+ 0.003 0.031 -10000 0 -0.18 13 13
GBP3 -0.048 0.19 -10000 0 -0.63 45 45
FOSL1 0.017 0.075 -10000 0 -0.44 14 14
NFAT1-c-4/MAF/IRF4 -0.066 0.26 -10000 0 -0.81 43 43
DGKA -0.022 0.11 -10000 0 -0.42 20 20
CREM 0.027 0.004 -10000 0 -10000 0 0
NFAT1-c-4/PPARG -0.057 0.22 -10000 0 -0.77 33 33
CTLA4 -0.047 0.17 -10000 0 -0.57 41 41
NFAT1-c-4 (dimer)/EGR1 -0.057 0.23 -10000 0 -0.77 36 36
NFAT1-c-4 (dimer)/EGR4 -0.065 0.23 -10000 0 -0.78 36 36
FOS -0.012 0.092 -10000 0 -0.45 18 18
IFNG -0.14 0.34 -10000 0 -0.95 70 70
T cell activation 0 0.16 -10000 0 -0.62 5 5
MAF 0.021 0.053 -10000 0 -0.44 7 7
T-helper 2 cell lineage commitment 0 0 -10000 0 -10000 0 0
activation-induced cell death of T cells 0.06 0.21 0.79 34 -10000 0 34
TNF -0.086 0.23 -10000 0 -0.74 45 45
FASLG -0.15 0.47 -10000 0 -1.3 66 66
TBX21 -0.009 0.12 -10000 0 -0.33 62 62
BATF3 0.022 0.05 -10000 0 -0.44 6 6
PRKCQ -0.019 0.14 -10000 0 -0.45 49 49
PTPN1 -0.021 0.11 -10000 0 -0.48 12 12
NFAT1-c-4/ICER1 -0.055 0.22 -10000 0 -0.77 33 33
GATA3 0.015 0.08 -10000 0 -0.44 16 16
T-helper 1 cell differentiation -0.13 0.33 -10000 0 -0.91 71 71
IL2RA -0.15 0.36 -10000 0 -0.99 69 69
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
CASP3 -0.021 0.11 -10000 0 -0.44 17 17
E2F1 0.017 0.024 -10000 0 -0.44 1 1
PPARG 0.02 0.052 -10000 0 -0.44 7 7
SLC3A2 -0.021 0.11 -10000 0 -0.43 18 18
IRF4 -0.019 0.15 -10000 0 -0.44 59 59
PTGS2 -0.12 0.32 -10000 0 -0.78 76 76
CSF2 -0.12 0.33 -10000 0 -0.8 76 76
JunB/Fra1/NFAT1-c-4 -0.052 0.22 -10000 0 -0.74 35 35
IL4 -0.073 0.24 -10000 0 -0.83 33 33
IL5 -0.1 0.3 -10000 0 -0.77 64 64
IL2 -0.001 0.16 -10000 0 -0.63 5 5
IL3 -0.03 0.12 -10000 0 -0.58 18 18
RNF128 0.012 0.079 -10000 0 -0.51 12 12
NFATC1 -0.061 0.21 -10000 0 -0.8 34 34
CDK4 0.039 0.13 0.57 18 -10000 0 18
PTPRK -0.019 0.11 -10000 0 -0.46 15 15
IL8 -0.13 0.33 -10000 0 -0.8 77 77
POU2F1 0.021 0.053 -10000 0 -0.44 7 7
PDGFR-beta signaling pathway

Figure S36.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S36.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
S1P1/Sphingosine-1-phosphate 0.035 0.12 0.22 26 -0.37 18 44
PDGFB-D/PDGFRB/SLAP 0.026 0.059 -10000 0 -0.32 14 14
PDGFB-D/PDGFRB/APS/CBL 0.041 0.063 -10000 0 -0.27 20 20
AKT1 0.044 0.097 0.25 16 -0.4 1 17
mol:PI-4-5-P2 0 0.001 -10000 0 -10000 0 0
mol:Sphingosine-1-phosphate 0.065 0.14 0.24 87 -0.43 16 103
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
FGR -0.011 0.17 -10000 0 -0.51 46 46
mol:Ca2+ 0.051 0.14 0.23 88 -0.47 15 103
MYC 0.076 0.18 0.38 75 -0.55 13 88
SHC1 0.026 0.004 -10000 0 -10000 0 0
HRAS/GDP 0.056 0.078 0.17 1 -0.23 6 7
LRP1/PDGFRB/PDGFB 0.045 0.055 -10000 0 -0.29 13 13
GRB10 0.021 0.04 -10000 0 -0.44 4 4
PTPN11 0.022 0.044 -10000 0 -0.44 5 5
GO:0007205 0.05 0.14 0.23 84 -0.48 15 99
PTEN 0.025 0.006 -10000 0 -10000 0 0
GRB2 0.026 0.004 -10000 0 -10000 0 0
GRB7 0.025 0.006 -10000 0 -10000 0 0
PDGFB-D/PDGFRB/SHP2 0.032 0.055 -10000 0 -0.32 13 13
PDGFB-D/PDGFRB/GRB10 0.03 0.05 -10000 0 -0.32 10 10
cell cycle arrest 0.026 0.059 -10000 0 -0.32 14 14
HRAS 0.026 0.021 -10000 0 -0.44 1 1
HIF1A 0.036 0.092 0.24 16 -0.3 5 21
GAB1 0.033 0.14 0.31 2 -0.44 17 19
mol:GTP 0 0 -10000 0 -10000 0 0
DNM2 0.047 0.14 0.22 88 -0.44 12 100
PDGFB-D/PDGFRB 0.024 0.042 -10000 0 -0.29 5 5
mol:GDP 0 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB/LMW-PTP 0.035 0.044 -10000 0 -0.32 8 8
S1P1/Sphingosine-1-phosphate/PDGFB-D/PDGFRB 0.001 0.082 0.23 2 -0.35 17 19
positive regulation of MAPKKK cascade 0.032 0.055 -10000 0 -0.32 13 13
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
mol:IP3 0.051 0.14 0.23 84 -0.49 15 99
E5 0 0.001 -10000 0 -10000 0 0
CSK 0.022 0.021 -10000 0 -0.44 1 1
PDGFB-D/PDGFRB/GRB7 0.034 0.042 -10000 0 -0.32 7 7
SHB 0.026 0.005 -10000 0 -10000 0 0
BLK -0.086 0.22 -10000 0 -0.48 116 116
PTPN2 0.022 0.023 -10000 0 -0.43 1 1
PDGFB-D/PDGFRB/SNX15 0.035 0.044 -10000 0 -0.32 8 8
BCAR1 0.025 0.029 -10000 0 -0.44 2 2
VAV2 0.04 0.16 0.26 37 -0.47 19 56
CBL 0.026 0.004 -10000 0 -10000 0 0
PDGFB-D/PDGFRB/DEP1 0.034 0.046 -10000 0 -0.32 9 9
LCK 0.001 0.14 -10000 0 -0.46 35 35
PDGFRB 0.022 0.058 -10000 0 -0.45 8 8
ACP1 0.027 0.002 -10000 0 -10000 0 0
HCK -0.01 0.12 -10000 0 -0.58 20 20
ABL1 0.032 0.15 0.22 87 -0.4 25 112
PDGFB-D/PDGFRB/CBL 0.022 0.15 0.37 1 -0.5 20 21
PTPN1 0.015 0.014 -10000 0 -10000 0 0
SNX15 0.026 0.004 -10000 0 -10000 0 0
STAT3 0.026 0.004 -10000 0 -10000 0 0
STAT1 0.026 0.029 -10000 0 -0.44 2 2
cell proliferation 0.076 0.17 0.37 77 -0.49 13 90
SLA 0.016 0.06 -10000 0 -0.44 9 9
actin cytoskeleton reorganization 0.061 0.1 0.18 153 -0.27 6 159
SRC 0.006 0.053 -10000 0 -0.35 5 5
PI3K -0.017 0.03 -10000 0 -0.23 7 7
PDGFB-D/PDGFRB/GRB7/SHC 0.047 0.04 -10000 0 -0.27 7 7
SH2B2 0.017 0.069 -10000 0 -0.44 12 12
PLCgamma1/SPHK1 0.066 0.14 0.24 87 -0.45 16 103
LYN 0.013 0.087 -10000 0 -0.48 9 9
LRP1 0.023 0.044 -10000 0 -0.44 5 5
SOS1 0.027 0.002 -10000 0 -10000 0 0
STAT5B 0.026 0.004 -10000 0 -10000 0 0
STAT5A 0.026 0.004 -10000 0 -10000 0 0
NCK1-2/p130 Cas 0.036 0.055 -10000 0 -0.28 6 6
SPHK1 0.018 0.083 -10000 0 -0.44 17 17
EDG1 0.003 0.004 -10000 0 -10000 0 0
mol:DAG 0.051 0.14 0.23 84 -0.49 15 99
PLCG1 0.05 0.14 0.23 83 -0.5 15 98
NHERF/PDGFRB 0.047 0.043 -10000 0 -0.27 9 9
YES1 -0.016 0.16 -10000 0 -0.51 46 46
cell migration 0.047 0.043 -10000 0 -0.27 9 9
SHC/Grb2/SOS1 0.035 0.051 -10000 0 -0.24 5 5
SLC9A3R2 0.025 0.02 -10000 0 -0.44 1 1
SLC9A3R1 0.026 0.004 -10000 0 -10000 0 0
NHERF1-2/PDGFRB/PTEN 0.058 0.046 -10000 0 -0.25 9 9
FYN 0.004 0.11 -10000 0 -0.47 19 19
DOK1 0.042 0.09 0.17 168 -0.26 5 173
HRAS/GTP 0.019 0.015 -10000 0 -0.32 1 1
PDGFB 0.025 0.021 -10000 0 -0.44 1 1
RAC1 0.054 0.17 0.32 50 -0.46 20 70
PRKCD 0.042 0.092 0.18 167 -0.26 5 172
FER 0.041 0.093 0.18 165 -0.26 7 172
MAPKKK cascade 0.058 0.1 0.3 14 -0.24 3 17
RASA1 0.042 0.091 0.18 164 -0.26 5 169
NCK1 0.025 0.028 -10000 0 -0.44 2 2
NCK2 0.026 0.02 -10000 0 -0.44 1 1
p62DOK/Csk 0.059 0.077 -10000 0 -0.24 6 6
PDGFB-D/PDGFRB/SHB 0.035 0.044 -10000 0 -0.32 8 8
chemotaxis 0.032 0.14 0.22 88 -0.39 25 113
STAT1-3-5/STAT1-3-5 0.029 0.046 -10000 0 -0.24 6 6
Bovine Papilomavirus E5/PDGFRB 0.016 0.041 -10000 0 -0.32 8 8
PTPRJ 0.025 0.02 -10000 0 -0.44 1 1
Effects of Botulinum toxin

Figure S37.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S37.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
STX1A -0.008 0.02 -10000 0 -0.32 2 2
UniProt:P19321 0 0 -10000 0 -10000 0 0
RIMS1/UNC13B 0.023 0.077 -10000 0 -0.32 26 26
STXBP1 0.015 0.074 -10000 0 -0.44 14 14
ACh/CHRNA1 -0.003 0.08 0.12 4 -0.18 70 74
RAB3GAP2/RIMS1/UNC13B 0.035 0.075 -10000 0 -0.27 29 29
mol:Ca2+ 0 0 -10000 0 -10000 0 0
UniProt:P30996 0 0 -10000 0 -10000 0 0
UniProt:Q60393 0 0 -10000 0 -10000 0 0
CST086 0 0 -10000 0 -10000 0 0
RIMS1 -0.005 0.099 -10000 0 -0.44 25 25
mol:ACh -0.003 0.048 0.078 77 -0.11 48 125
RAB3GAP2 0.024 0.034 -10000 0 -0.44 3 3
STX1A/SNAP25/VAMP2 0.002 0.096 0.23 1 -0.24 40 41
UniProt:P10844 0 0 -10000 0 -10000 0 0
muscle contraction -0.003 0.08 0.12 4 -0.18 70 74
UNC13B 0.025 0.02 -10000 0 -0.44 1 1
CHRNA1 0.004 0.11 -10000 0 -0.44 29 29
UniProt:P10845 0 0 -10000 0 -10000 0 0
ACh/Synaptotagmin 1 -0.047 0.13 0.13 5 -0.26 133 138
SNAP25 -0.006 0.048 -10000 0 -0.26 19 19
VAMP2 0.003 0.002 -10000 0 -10000 0 0
SYT1 -0.066 0.19 -10000 0 -0.44 112 112
UniProt:Q00496 0 0 -10000 0 -10000 0 0
STXIA/STXBP1 0.013 0.05 -10000 0 -0.27 16 16
STX1A/SNAP25 fragment 1/VAMP2 0.002 0.096 0.23 1 -0.24 40 41
Calcium signaling in the CD4+ TCR pathway

Figure S38.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S38.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC1 -0.014 0.051 -10000 0 -0.3 10 10
NFATC2 -0.023 0.075 -10000 0 -0.3 36 36
NFATC3 -0.011 0.037 -10000 0 -0.12 7 7
CD40LG -0.067 0.24 0.35 2 -0.56 77 79
PTGS2 -0.07 0.24 0.35 1 -0.54 79 80
JUNB 0.024 0.035 -10000 0 -0.44 3 3
CaM/Ca2+/Calcineurin A alpha-beta B1 0.003 0.029 -10000 0 -10000 0 0
CaM/Ca2+ 0.003 0.029 -10000 0 -10000 0 0
CALM1 0.01 0.027 -10000 0 -10000 0 0
JUN 0.008 0.048 -10000 0 -0.46 4 4
mol:Ca2+ -0.006 0.012 -10000 0 -10000 0 0
Calcineurin A alpha-beta B1/FKBP12/FK506 0.01 0.013 -10000 0 -10000 0 0
FOSL1 0.017 0.075 -10000 0 -0.44 14 14
CREM 0.027 0.004 -10000 0 -10000 0 0
Jun/NFAT1-c-4/p21SNFT -0.012 0.15 -10000 0 -0.36 54 54
FOS -0.002 0.087 -10000 0 -0.44 18 18
IFNG -0.07 0.24 0.35 1 -0.52 86 87
AP-1/NFAT1-c-4 -0.051 0.25 -10000 0 -0.58 72 72
FASLG -0.068 0.24 0.35 1 -0.54 80 81
NFAT1-c-4/ICER1 -0.026 0.092 0.18 1 -0.28 43 44
IL2RA -0.068 0.24 0.35 2 -0.58 74 76
FKBP12/FK506 0.016 0.008 -10000 0 -10000 0 0
CSF2 -0.073 0.25 0.35 2 -0.57 82 84
JunB/Fra1/NFAT1-c-4 0.003 0.13 0.21 1 -0.29 47 48
IL4 -0.057 0.21 0.34 2 -0.52 65 67
IL2 -0.017 0.15 -10000 0 -0.85 17 17
IL3 -0.015 0.13 -10000 0 -0.65 20 20
FKBP1A 0.021 0.011 -10000 0 -10000 0 0
BATF3 0.022 0.05 -10000 0 -0.44 6 6
mol:FK506 0 0 -10000 0 -10000 0 0
POU2F1 0.021 0.053 -10000 0 -0.44 7 7
BMP receptor signaling

Figure S39.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S39.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BMP7/BMPR2/BMPR1A-1B/FS -0.021 0.14 -9999 0 -0.28 102 102
SMAD6-7/SMURF1 0.036 0.039 -9999 0 -0.35 3 3
NOG 0.015 0.052 -9999 0 -0.44 5 5
SMAD9 -0.044 0.17 -9999 0 -0.51 62 62
SMAD4 0.019 0.012 -9999 0 -10000 0 0
SMAD5 -0.041 0.14 -9999 0 -0.42 44 44
BMP7/USAG1 -0.051 0.15 -9999 0 -0.36 106 106
SMAD5/SKI -0.035 0.15 -9999 0 -0.4 53 53
SMAD1 -0.006 0.074 -9999 0 -0.42 10 10
BMP2 0.017 0.05 -9999 0 -0.44 6 6
SMAD1/SMAD1/SMAD4 0.009 0.07 -9999 0 -0.39 7 7
BMPR1A 0.025 0.021 -9999 0 -0.44 1 1
BMPR1B -0.006 0.13 -9999 0 -0.44 42 42
BMPR1A-1B/BAMBI 0.013 0.12 -9999 0 -0.28 74 74
AHSG 0.018 0.043 -9999 0 -0.44 2 2
CER1 -0.002 0.025 -9999 0 -10000 0 0
BMP2-4/CER1 0.031 0.054 -9999 0 -0.28 13 13
BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA -0.035 0.13 -9999 0 -0.36 50 50
BMP2-4 (homodimer) 0.023 0.057 -9999 0 -0.31 14 14
RGMB 0.028 0.026 -9999 0 -0.44 1 1
BMP6/BMPR2/BMPR1A-1B 0.036 0.1 -9999 0 -0.26 56 56
RGMA -0.018 0.14 -9999 0 -0.44 56 56
SMURF1 0.025 0.006 -9999 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP -0.028 0.12 -9999 0 -0.34 43 43
BMP2-4/USAG1 -0.008 0.12 -9999 0 -0.28 81 81
SMAD6/SMURF1/SMAD5 -0.036 0.15 -9999 0 -0.4 50 50
SOSTDC1 -0.044 0.17 -9999 0 -0.44 83 83
BMP7/BMPR2/BMPR1A-1B -0.015 0.12 -9999 0 -0.28 87 87
SKI 0.025 0.006 -9999 0 -10000 0 0
BMP6 (homodimer) 0.019 0.066 -9999 0 -0.44 11 11
HFE2 -0.008 0.02 -9999 0 -10000 0 0
ZFYVE16 0.012 0.081 -9999 0 -0.44 17 17
MAP3K7 0.026 0.004 -9999 0 -10000 0 0
BMP2-4/CHRD 0.025 0.082 -9999 0 -0.3 29 29
SMAD5/SMAD5/SMAD4 -0.035 0.14 -9999 0 -0.41 47 47
MAPK1 0.025 0.006 -9999 0 -10000 0 0
TAK1/TAB family -0.016 0.11 -9999 0 -0.3 45 45
BMP7 (homodimer) -0.037 0.15 -9999 0 -0.44 66 66
NUP214 0.026 0.003 -9999 0 -10000 0 0
BMP6/FETUA 0.035 0.058 -9999 0 -0.32 13 13
SMAD1/SKI 0.006 0.077 -9999 0 -0.39 11 11
SMAD6 0.024 0.029 -9999 0 -0.44 2 2
CTDSP2 0.027 0.002 -9999 0 -10000 0 0
BMP2-4/FETUA 0.037 0.057 -9999 0 -0.28 13 13
MAP3K7IP1 0 0 -9999 0 -10000 0 0
GREM1 -0.017 0.14 -9999 0 -0.44 55 55
BMPR2 (homodimer) 0.022 0.044 -9999 0 -0.44 5 5
GADD34/PP1CA 0.041 0.057 -9999 0 -0.27 17 17
BMPR1A-1B (homodimer) 0.015 0.098 -9999 0 -0.32 43 43
CHRDL1 -0.039 0.18 -9999 0 -0.44 91 91
ENDOFIN/SMAD1 0 0.089 -9999 0 -0.41 12 12
SMAD6-7/SMURF1/SMAD1 0.017 0.082 -9999 0 -0.43 8 8
SMAD6/SMURF1 0.025 0.006 -9999 0 -10000 0 0
BAMBI 0.002 0.11 -9999 0 -0.44 34 34
SMURF2 0.024 0.035 -9999 0 -0.44 3 3
BMP2-4/CHRDL1 -0.005 0.13 -9999 0 -0.28 91 91
BMP2-4/GREM1 0.007 0.1 -9999 0 -0.27 62 62
SMAD7 0.018 0.03 -9999 0 -0.44 2 2
SMAD8A/SMAD8A/SMAD4 -0.044 0.18 -9999 0 -0.46 75 75
SMAD1/SMAD6 0.005 0.077 -9999 0 -0.39 11 11
TAK1/SMAD6 0.037 0.01 -9999 0 -10000 0 0
BMP7 -0.037 0.15 -9999 0 -0.44 66 66
BMP6 0.019 0.066 -9999 0 -0.44 11 11
MAP3K7IP2 0 0 -9999 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 -0.04 0.13 -9999 0 -0.34 63 63
PPM1A 0.025 0.007 -9999 0 -10000 0 0
SMAD1/SMURF2 0.005 0.081 -9999 0 -0.4 12 12
SMAD7/SMURF1 0.027 0.027 -9999 0 -0.32 2 2
CTDSPL 0.026 0.003 -9999 0 -10000 0 0
PPP1CA 0.026 0.004 -9999 0 -10000 0 0
XIAP 0.026 0.02 -9999 0 -0.44 1 1
CTDSP1 0.026 0.02 -9999 0 -0.44 1 1
PPP1R15A 0.026 0.004 -9999 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/FS -0.049 0.16 -9999 0 -0.43 62 62
CHRD 0.008 0.094 -9999 0 -0.44 23 23
BMPR2 0.023 0.044 -9999 0 -0.44 5 5
BMP2-4/BMPR2/BMPR1A-1B/RGM -0.04 0.12 -9999 0 -0.38 39 39
BMP4 0.02 0.058 -9999 0 -0.44 8 8
FST -0.001 0.12 -9999 0 -0.44 36 36
BMP2-4/NOG 0.034 0.06 -9999 0 -0.28 15 15
BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 -0.008 0.12 -9999 0 -0.26 85 85
Angiopoietin receptor Tie2-mediated signaling

Figure S40.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S40.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
AKT1 0.007 0.25 -10000 0 -0.83 39 39
NCK1/PAK1/Dok-R -0.035 0.1 -10000 0 -0.4 39 39
NCK1/Dok-R -0.013 0.27 -10000 0 -1 36 36
PIK3CA 0.024 0.028 -10000 0 -0.44 2 2
mol:beta2-estradiol 0.006 0.054 0.24 29 -10000 0 29
RELA 0.026 0.004 -10000 0 -10000 0 0
SHC1 0.027 0.004 -10000 0 -10000 0 0
Rac/GDP 0.018 0.006 -10000 0 -10000 0 0
F2 -0.044 0.15 0.28 28 -0.44 49 77
TNIP2 0.025 0.02 -10000 0 -0.44 1 1
NF kappa B/RelA 0.019 0.26 -10000 0 -0.94 36 36
FN1 -0.01 0.14 -10000 0 -0.44 52 52
PLD2 -0.043 0.27 -10000 0 -1 36 36
PTPN11 0.022 0.044 -10000 0 -0.44 5 5
GRB14 -0.049 0.18 -10000 0 -0.44 92 92
ELK1 -0.016 0.25 -10000 0 -0.94 36 36
GRB7 0.025 0.006 -10000 0 -10000 0 0
PAK1 0.026 0.004 -10000 0 -10000 0 0
Tie2/Ang1/alpha5/beta1 Integrin 0.004 0.29 -10000 0 -1 38 38
CDKN1A 0.017 0.19 0.45 2 -0.59 37 39
ITGA5 0.026 0.036 -10000 0 -0.44 3 3
mol:GTP 0 0 -10000 0 -10000 0 0
RasGAP/Dok-R -0.014 0.27 -10000 0 -1 36 36
CRK 0.022 0.011 -10000 0 -10000 0 0
mol:NO 0.023 0.2 0.35 16 -0.62 39 55
PLG -0.054 0.27 -10000 0 -1 36 36
mol:GDP 0 0 -10000 0 -10000 0 0
chemokinesis 0.003 0.23 -10000 0 -0.81 37 37
GRB2 0.026 0.004 -10000 0 -10000 0 0
PIK3R1 0.025 0.029 -10000 0 -0.44 2 2
ANGPT2 -0.03 0.21 0.42 1 -0.7 24 25
BMX -0.055 0.28 -10000 0 -1 37 37
ANGPT1 -0.029 0.28 -10000 0 -1.2 29 29
tube development 0.005 0.2 0.4 4 -0.63 40 44
ANGPT4 0.016 0.016 -10000 0 -10000 0 0
response to hypoxia -0.003 0.018 -10000 0 -10000 0 0
Tie2/Ang1/GRB14 -0.034 0.3 -10000 0 -1.1 36 36
alpha5/beta1 Integrin 0.039 0.028 -10000 0 -0.32 3 3
FGF2 0.007 0.097 -10000 0 -0.44 24 24
STAT5A (dimer) 0.013 0.23 0.44 1 -0.71 41 42
mol:L-citrulline 0.023 0.2 0.35 16 -0.62 39 55
AGTR1 -0.011 0.14 -10000 0 -0.44 52 52
MAPK14 -0.021 0.28 -10000 0 -1 37 37
Tie2/SHP2 0.012 0.18 -10000 0 -0.94 16 16
TEK -0.01 0.19 -10000 0 -1.2 12 12
RPS6KB1 0.007 0.24 0.45 2 -0.81 38 40
Angiotensin II/AT1 -0.005 0.1 -10000 0 -0.31 52 52
Tie2/Ang1/GRB2 -0.006 0.29 -10000 0 -1.1 36 36
MAPK3 -0.04 0.25 -10000 0 -0.95 36 36
MAPK1 -0.04 0.25 -10000 0 -0.95 36 36
Tie2/Ang1/GRB7 -0.007 0.29 -10000 0 -1.1 36 36
NFKB1 0.025 0.02 -10000 0 -0.44 1 1
MAPK8 -0.042 0.27 -10000 0 -1 36 36
PI3K -0.004 0.28 -10000 0 -0.95 38 38
FES -0.036 0.3 -10000 0 -1.1 37 37
Crk/Dok-R -0.014 0.27 -10000 0 -1 36 36
Tie2/Ang1/ABIN2 -0.007 0.29 -10000 0 -1.1 36 36
blood circulation 0 0 -10000 0 -10000 0 0
negative regulation of caspase activity 0.016 0.22 0.37 1 -0.74 39 40
STAT5A 0.026 0.004 -10000 0 -10000 0 0
mol:ROS 0 0 -10000 0 -10000 0 0
PTK2 0.029 0.25 0.42 8 -0.79 38 46
Tie2/Ang2 -0.028 0.25 0.44 1 -0.84 39 40
Tie2/Ang1 -0.04 0.29 -10000 0 -1.1 36 36
FOXO1 0.03 0.24 0.41 5 -0.74 39 44
ELF1 0.018 0.042 -10000 0 -0.32 5 5
ELF2 -0.037 0.27 -10000 0 -1 36 36
mol:Choline -0.04 0.25 -10000 0 -0.98 36 36
cell migration -0.017 0.065 -10000 0 -0.22 43 43
FYN -0.002 0.23 0.43 2 -0.72 39 41
DOK2 0.014 0.057 -10000 0 -0.44 8 8
negative regulation of cell cycle 0.02 0.18 0.39 6 -0.53 39 45
ETS1 0.017 0.069 -10000 0 -0.26 30 30
PXN 0.034 0.22 0.37 20 -0.66 38 58
ITGB1 0.027 0.002 -10000 0 -10000 0 0
NOS3 0.017 0.22 0.38 6 -0.71 39 45
RAC1 0.024 0.008 -10000 0 -10000 0 0
TNF 0.004 0.11 -10000 0 -0.35 44 44
MAPKKK cascade -0.04 0.25 -10000 0 -0.98 36 36
RASA1 0.024 0.028 -10000 0 -0.44 2 2
Tie2/Ang1/Shc -0.004 0.29 -10000 0 -1.1 36 36
NCK1 0.025 0.028 -10000 0 -0.44 2 2
vasculogenesis 0.026 0.18 0.34 18 -0.55 40 58
mol:Phosphatidic acid -0.04 0.25 -10000 0 -0.98 36 36
mol:Angiotensin II 0.001 0.002 -10000 0 -10000 0 0
mol:NADP 0.023 0.2 0.35 16 -0.62 39 55
Rac1/GTP 0.009 0.22 -10000 0 -0.74 38 38
MMP2 -0.049 0.28 -10000 0 -1.1 36 36
VEGFR1 specific signals

Figure S41.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S41.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR1 homodimer/VEGFB homodimer 0.017 0.045 0.19 1 -0.3 8 9
VEGFR1 homodimer/NRP1 0.004 0.04 -10000 0 -0.3 8 8
mol:DAG 0.005 0.064 0.19 43 -0.36 5 48
VEGFR1 homodimer/NRP1/VEGFR 121 0.016 0.039 -10000 0 -0.32 5 5
CaM/Ca2+ 0.022 0.061 -10000 0 -0.34 5 5
HIF1A 0.022 0.067 -10000 0 -0.49 9 9
GAB1 0.026 0.005 -10000 0 -10000 0 0
AKT1 0.019 0.09 0.32 2 -0.4 8 10
PLCG1 0.005 0.065 0.19 43 -0.36 5 48
NOS3 0.067 0.13 0.28 77 -0.42 10 87
CBL 0.026 0.004 -10000 0 -10000 0 0
mol:NO 0.07 0.13 0.28 81 -0.4 10 91
FLT1 0.008 0.043 0.25 1 -0.39 5 6
PGF 0.025 0.031 -10000 0 -0.44 2 2
VEGFR1 homodimer/NRP2/VEGFR121 0.028 0.061 0.22 5 -0.3 12 17
CALM1 0.025 0.007 -10000 0 -10000 0 0
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
eNOS/Hsp90 0.081 0.13 0.29 83 -0.45 7 90
endothelial cell proliferation 0.067 0.13 0.31 70 -0.45 6 76
mol:Ca2+ 0.005 0.064 0.19 43 -0.36 5 48
MAPK3 0.001 0.06 0.17 42 -0.36 4 46
MAPK1 0.001 0.058 0.17 39 -0.4 3 42
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
PLGF homodimer 0.025 0.031 -10000 0 -0.44 2 2
PRKACA 0.026 0.003 -10000 0 -10000 0 0
RP11-342D11.1 0 0 -10000 0 -10000 0 0
CAV1 0.024 0.041 -10000 0 -0.44 4 4
VEGFA homodimer 0.026 0.004 -10000 0 -10000 0 0
VEGFR1 homodimer/VEGFA homodimer 0.018 0.043 0.19 1 -0.31 7 8
platelet activating factor biosynthetic process 0.038 0.12 0.33 69 -0.39 3 72
PI3K 0.036 0.062 -10000 0 -0.35 9 9
PRKCA 0.003 0.062 0.18 43 -0.34 5 48
PRKCB -0.002 0.075 0.18 42 -0.28 17 59
VEGFR1 homodimer/PLGF homodimer 0.018 0.05 0.21 3 -0.3 10 13
VEGFA 0.026 0.004 -10000 0 -10000 0 0
VEGFB 0.026 0.004 -10000 0 -10000 0 0
mol:IP3 0.005 0.064 0.19 43 -0.36 5 48
RASA1 0.025 0.093 0.19 116 -0.33 7 123
NRP2 0.021 0.061 -10000 0 -0.44 9 9
VEGFR1 homodimer 0.008 0.043 0.25 1 -0.39 5 6
VEGFB homodimer 0.026 0.004 -10000 0 -10000 0 0
NCK1 0.025 0.028 -10000 0 -0.44 2 2
eNOS/Caveolin-1 0.072 0.12 0.28 67 -0.5 6 73
PTPN11 0.022 0.044 -10000 0 -0.44 5 5
mol:PI-3-4-5-P3 0.035 0.061 -10000 0 -0.35 9 9
mol:L-citrulline 0.07 0.13 0.28 81 -0.4 10 91
VEGFR1 homodimer/VEGFA homodimer/CBL/CD2AP 0.028 0.078 -10000 0 -0.3 22 22
VEGFR1 homodimer/VEGFA homodimer/NCK1 0.028 0.048 -10000 0 -0.31 7 7
CD2AP 0.004 0.1 -10000 0 -0.44 27 27
PI3K/GAB1 0.077 0.077 -10000 0 -0.34 9 9
PDPK1 0.017 0.092 0.34 2 -0.39 6 8
VEGFR1 homodimer/VEGFA homodimer/SHP2 0.027 0.057 -10000 0 -0.4 7 7
mol:NADP 0.07 0.13 0.28 81 -0.4 10 91
HSP90AA1 0.024 0.021 -10000 0 -0.44 1 1
ubiquitin-dependent protein catabolic process 0.027 0.076 -10000 0 -0.3 22 22
VEGFR1 homodimer/NRP2 0.016 0.063 0.22 5 -0.3 15 20
Visual signal transduction: Rods

Figure S42.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S42.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:K + 0.025 0.021 -10000 0 -0.44 1 1
GNAT1/GTP 0.015 0.005 -10000 0 -10000 0 0
Metarhodopsin II/Arrestin 0.026 0.006 -10000 0 -10000 0 0
PDE6G/GNAT1/GTP 0.018 0.063 -10000 0 -0.27 25 25
mol:GTP 0 0 -10000 0 -10000 0 0
absorption of light 0 0 -10000 0 -10000 0 0
GNAT1 -0.009 0.019 -10000 0 -10000 0 0
GRK1 -0.009 0.016 -10000 0 -10000 0 0
CNG Channel -0.026 0.14 0.19 1 -0.27 132 133
mol:Na + 0.001 0.094 -10000 0 -0.24 65 65
mol:ADP -0.009 0.016 -10000 0 -10000 0 0
RGS9-1/Gbeta5/R9AP 0.028 0.085 -10000 0 -0.28 37 37
mol:GDP 0 0 -10000 0 -10000 0 0
cGMP/CNG Channel 0.009 0.1 -10000 0 -0.24 65 65
CNGB1 0.006 0.026 -10000 0 -10000 0 0
RDH5 0.021 0.056 -10000 0 -0.44 8 8
SAG -0.009 0.018 -10000 0 -10000 0 0
mol:Ca2+ -0.049 0.09 0.34 11 -0.29 13 24
Na + (4 Units) -0.012 0.089 -10000 0 -0.23 65 65
RGS9 0.008 0.095 -10000 0 -0.44 23 23
GNB1/GNGT1 0.018 0.079 -10000 0 -0.32 28 28
GNAT1/GDP 0.034 0.077 -10000 0 -0.24 37 37
GUCY2D 0.015 0.026 -10000 0 -10000 0 0
GNGT1 -0.006 0.1 -10000 0 -0.44 28 28
GUCY2F -0.016 0.011 -10000 0 -10000 0 0
GNB5 0.024 0.029 -10000 0 -0.44 2 2
mol:GMP (4 units) -0.044 0.12 0.18 3 -0.27 108 111
mol:11-cis-retinal 0.021 0.056 -10000 0 -0.44 8 8
mol:cGMP 0.019 0.069 -10000 0 -0.24 29 29
GNB1 0.025 0.006 -10000 0 -10000 0 0
Rhodopsin 0.029 0.043 -10000 0 -0.32 8 8
SLC24A1 0.025 0.021 -10000 0 -0.44 1 1
CNGA1 -0.002 0.12 -10000 0 -0.44 37 37
Metarhodopsin II 0.019 0.012 -10000 0 -10000 0 0
mol:Ca ++ 0 0 -10000 0 -10000 0 0
GC1/GCAP Family 0.037 0.074 -10000 0 -0.25 29 29
RGS9BP 0.009 0.074 -10000 0 -0.44 14 14
Metarhodopsin II/Transducin -0.002 0.054 -10000 0 -0.23 28 28
GCAP Family/Ca ++ 0.03 0.067 -10000 0 -0.25 29 29
PDE6A/B -0.019 0.15 -10000 0 -0.34 91 91
mol:Pi 0.027 0.084 -10000 0 -0.28 37 37
mol:all-trans-retinal 0 0 -10000 0 -10000 0 0
Transducin 0.027 0.066 -10000 0 -0.25 28 28
PDE6B 0.009 0.093 -10000 0 -0.44 22 22
PDE6A -0.033 0.16 -10000 0 -0.44 76 76
PDE6G 0.006 0.098 -10000 0 -0.44 25 25
RHO -0.014 0.015 -10000 0 -10000 0 0
PDE6 -0.007 0.16 -10000 0 -0.28 128 128
GUCA1A 0.009 0.066 -10000 0 -0.44 10 10
GC2/GCAP Family 0.041 0.071 -10000 0 -0.26 29 29
GUCA1C -0.017 0.01 -10000 0 -10000 0 0
GUCA1B 0.011 0.085 -10000 0 -0.44 19 19
Nongenotropic Androgen signaling

Figure S43.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S43.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.006 0.013 -10000 0 -0.32 1 1
GNB1/GNG2 0.035 0.067 -10000 0 -0.26 25 25
regulation of S phase of mitotic cell cycle 0.007 0.044 -10000 0 -0.24 13 13
GNAO1 0.018 0.084 -10000 0 -0.44 17 17
HRAS 0.026 0.021 -10000 0 -0.44 1 1
SHBG/T-DHT 0.016 0.015 -10000 0 -0.07 4 4
PELP1 0.021 0.022 -10000 0 -0.44 1 1
AKT1 -0.006 0.013 -10000 0 -0.32 1 1
MAP2K1 0.04 0.099 0.17 182 -0.24 11 193
T-DHT/AR 0.009 0.066 -10000 0 -0.32 21 21
G-protein coupled receptor activity 0 0 -10000 0 -10000 0 0
mol:GTP 0 0.002 -10000 0 -0.008 25 25
GNAI2 0.026 0.004 -10000 0 -10000 0 0
GNAI3 0.026 0.005 -10000 0 -10000 0 0
GNAI1 0.018 0.063 -10000 0 -0.44 10 10
mol:GDP -0.011 0.063 -10000 0 -0.31 22 22
cell proliferation 0.03 0.13 0.27 8 -0.4 19 27
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
FOS 0.007 0.18 -10000 0 -0.77 25 25
mol:Ca2+ -0.004 0.018 -10000 0 -0.062 35 35
MAPK3 0.038 0.11 0.27 10 -0.33 12 22
MAPK1 0.014 0.11 0.2 1 -0.41 21 22
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
mol:IP3 0 0.001 -10000 0 -0.005 25 25
cAMP biosynthetic process -0.002 0.019 0.087 1 -10000 0 1
GNG2 0.021 0.045 -10000 0 -0.44 5 5
potassium channel inhibitor activity 0 0.001 -10000 0 -0.005 25 25
HRAS/GTP 0.02 0.054 -10000 0 -0.26 11 11
actin cytoskeleton reorganization 0.031 0.039 -10000 0 -0.29 6 6
SRC 0.015 0.023 -10000 0 -0.44 1 1
voltage-gated calcium channel activity 0 0.001 -10000 0 -0.005 25 25
PI3K 0.032 0.027 -10000 0 -0.27 4 4
apoptosis -0.028 0.12 0.37 28 -0.22 5 33
T-DHT/AR/PELP1 0.021 0.062 -10000 0 -0.26 22 22
HRAS/GDP 0.002 0.067 -10000 0 -0.3 22 22
CREB1 0.027 0.12 0.23 5 -0.39 28 33
RAC1-CDC42/GTP 0.039 0.042 -10000 0 -0.3 6 6
AR 0.009 0.093 -10000 0 -0.44 21 21
GNB1 0.025 0.006 -10000 0 -10000 0 0
RAF1 0.047 0.1 0.17 204 -0.25 11 215
RAC1-CDC42/GDP 0.039 0.081 -10000 0 -0.29 22 22
T-DHT/AR/PELP1/Src 0.021 0.052 -10000 0 -0.27 11 11
MAP2K2 0.04 0.1 0.16 186 -0.26 11 197
T-DHT/AR/PELP1/Src/PI3K 0.007 0.044 -10000 0 -0.24 13 13
GNAZ 0.015 0.071 -10000 0 -0.44 13 13
SHBG 0.018 0.025 -10000 0 -10000 0 0
Gi family/GNB1/GNG2/GDP -0.003 0.11 -10000 0 -0.44 21 21
mol:T-DHT 0 0.001 -10000 0 -0.004 24 24
RAC1 0.024 0.008 -10000 0 -10000 0 0
GNRH1 -0.008 0.03 -10000 0 -0.32 5 5
Gi family/GTP -0.015 0.07 -10000 0 -0.22 41 41
CDC42 0.022 0.04 -10000 0 -0.44 4 4
IGF1 pathway

Figure S44.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S44.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NCK2 0.026 0.02 -10000 0 -0.44 1 1
PTK2 0.021 0.022 -10000 0 -0.44 1 1
CRKL -0.015 0.072 -10000 0 -0.24 47 47
GRB2/SOS1/SHC 0.051 0.013 -10000 0 -10000 0 0
HRAS 0.026 0.021 -10000 0 -0.44 1 1
IRS1/Crk -0.003 0.075 -10000 0 -0.23 53 53
IGF-1R heterotetramer/IGF1/PTP1B 0.014 0.073 -10000 0 -0.27 28 28
AKT1 -0.036 0.063 0.2 3 -0.22 48 51
BAD -0.037 0.061 0.18 3 -0.22 37 40
mol:GTP 0 0 -10000 0 -10000 0 0
CRK -0.014 0.07 -10000 0 -0.23 51 51
IGF-1R heterotetramer/IGF1/IRS1/Shp2 0.005 0.085 -10000 0 -0.23 60 60
RAF1 -0.02 0.084 0.26 1 -0.47 9 10
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos 0.035 0.088 -10000 0 -0.23 46 46
YWHAZ 0.021 0.029 -10000 0 -0.44 2 2
IGF-1R heterotetramer/IGF1/IRS1 0.01 0.088 -10000 0 -0.25 55 55
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
RPS6KB1 -0.038 0.067 0.2 3 -0.24 43 46
GNB2L1 0.026 0.005 -10000 0 -10000 0 0
positive regulation of MAPKKK cascade -0.005 0.08 0.24 4 -0.42 4 8
PXN 0.027 0.002 -10000 0 -10000 0 0
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
cell adhesion 0 0 -10000 0 -10000 0 0
GRB2/SOS1 0.039 0.007 -10000 0 -10000 0 0
HRAS/GTP 0.009 0.073 -10000 0 -0.22 45 45
IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc 0.052 0.083 -10000 0 -0.22 43 43
IGF-1R heterotetramer 0.016 0.038 -10000 0 -0.51 1 1
IGF-1R heterotetramer/IGF1/IRS/Nck 0.022 0.089 -10000 0 -0.23 56 56
Crk/p130 Cas/Paxillin 0.033 0.085 0.21 1 -0.22 48 49
IGF1R 0.016 0.038 -10000 0 -0.51 1 1
IGF1 -0.01 0.14 -10000 0 -0.46 47 47
IRS2/Crk -0.003 0.066 -10000 0 -0.24 37 37
PI3K 0.031 0.092 -10000 0 -0.23 57 57
apoptosis 0.032 0.056 0.35 5 -0.23 1 6
HRAS/GDP 0.019 0.015 -10000 0 -0.32 1 1
PRKCD -0.022 0.1 -10000 0 -0.34 47 47
RAF1/14-3-3 E -0.008 0.08 0.25 2 -0.42 8 10
BAD/14-3-3 -0.034 0.059 0.24 1 -0.37 5 6
PRKCZ -0.036 0.062 0.2 3 -0.22 43 46
Crk/p130 Cas/Paxillin/FAK1 -0.003 0.071 -10000 0 -0.36 5 5
PTPN1 0.015 0.013 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 -0.018 0.11 -10000 0 -0.35 50 50
BCAR1 0.025 0.029 -10000 0 -0.44 2 2
IGF-1R heterotetramer/IGF1/SHC/GRB10 0.037 0.085 -10000 0 -0.24 43 43
mol:GDP 0 0 -10000 0 -10000 0 0
SOS1 0.027 0.002 -10000 0 -10000 0 0
IRS1/NCK2 -0.001 0.081 -10000 0 -0.23 56 56
GRB10 0.021 0.04 -10000 0 -0.44 4 4
PTPN11 -0.017 0.076 -10000 0 -0.23 60 60
IRS1 -0.015 0.08 -10000 0 -0.25 55 55
IRS2 -0.012 0.068 -10000 0 -0.25 37 37
IGF-1R heterotetramer/IGF1 0.008 0.11 -10000 0 -0.35 47 47
GRB2 0.026 0.004 -10000 0 -10000 0 0
PDPK1 -0.036 0.066 0.2 3 -0.23 49 52
YWHAE 0.022 0.01 -10000 0 -10000 0 0
PRKD1 -0.029 0.12 0.2 1 -0.38 50 51
SHC1 0.026 0.004 -10000 0 -10000 0 0
Plasma membrane estrogen receptor signaling

Figure S45.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S45.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GNB1/GNG2 0.036 0.082 -10000 0 -0.24 40 40
ER alpha/Gai/GDP/Gbeta gamma -0.027 0.16 -10000 0 -0.5 39 39
AKT1 -0.017 0.21 -10000 0 -0.76 40 40
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
E2/ER alpha (dimer)/PELP1/Src/PI3K -0.013 0.21 -10000 0 -0.76 40 40
mol:Ca2+ -0.009 0.11 -10000 0 -0.39 25 25
IGF1R 0.025 0.021 -10000 0 -0.44 1 1
E2/ER alpha (dimer)/Striatin 0.02 0.071 -10000 0 -0.27 31 31
SHC1 0.026 0.004 -10000 0 -10000 0 0
apoptosis 0.015 0.2 0.72 40 -10000 0 40
RhoA/GTP 0.002 0.072 -10000 0 -0.24 39 39
E2/ER alpha (dimer)/PELP1/Src/p130 Cas 0.031 0.15 0.28 1 -0.46 29 30
regulation of stress fiber formation 0.032 0.071 0.37 9 -0.21 5 14
E2/ERA-ERB (dimer) 0.015 0.078 -10000 0 -0.28 36 36
KRAS 0.022 0.044 -10000 0 -0.44 5 5
G13/GTP 0.02 0.061 -10000 0 -0.24 28 28
pseudopodium formation -0.032 0.071 0.21 5 -0.37 9 14
E2/ER alpha (dimer)/PELP1 0.017 0.066 -10000 0 -0.26 28 28
GRB2 0.026 0.004 -10000 0 -10000 0 0
GNG2 0.021 0.045 -10000 0 -0.44 5 5
GNAO1 0.018 0.084 -10000 0 -0.44 17 17
HRAS 0.026 0.021 -10000 0 -0.44 1 1
mol:GTP 0 0 -10000 0 -10000 0 0
mol:NO -0.023 0.17 0.23 1 -0.49 47 48
E2/ER beta (dimer) 0.012 0.047 -10000 0 -0.32 11 11
mol:GDP -0.014 0.1 -10000 0 -0.34 41 41
mol:NADP -0.023 0.17 0.23 1 -0.49 47 48
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
mol:IP3 -0.024 0.099 -10000 0 -0.4 25 25
IGF-1R heterotetramer 0.025 0.021 -10000 0 -0.44 1 1
PLCB1 -0.019 0.1 -10000 0 -0.41 25 25
PLCB2 -0.013 0.093 -10000 0 -0.41 22 22
IGF1 -0.008 0.13 -10000 0 -0.44 47 47
mol:L-citrulline -0.023 0.17 0.23 1 -0.49 47 48
RHOA 0.025 0.02 -10000 0 -0.44 1 1
Gai/GDP -0.004 0.17 -10000 0 -0.76 25 25
JNK cascade 0.012 0.047 -10000 0 -0.31 11 11
BCAR1 0.025 0.029 -10000 0 -0.44 2 2
ESR2 0.016 0.066 -10000 0 -0.44 11 11
GNAQ 0.022 0.044 -10000 0 -0.44 5 5
ESR1 0.004 0.1 -10000 0 -0.44 27 27
Gq family/GDP/Gbeta gamma -0.015 0.15 -10000 0 -0.59 27 27
E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 0.026 0.096 -10000 0 -0.47 10 10
E2/ER alpha (dimer)/PELP1/Src/p52 SHC 0.03 0.15 0.28 1 -0.45 29 30
GNAZ 0.015 0.071 -10000 0 -0.44 13 13
E2/ER alpha (dimer) 0.005 0.073 -10000 0 -0.32 27 27
STRN 0.023 0.04 -10000 0 -0.44 4 4
GNAL 0.015 0.065 -10000 0 -0.44 10 10
PELP1 0.021 0.022 -10000 0 -0.44 1 1
MAPK11 0.001 0.045 -10000 0 -0.27 14 14
GNAI2 0.026 0.004 -10000 0 -10000 0 0
GNAI3 0.026 0.005 -10000 0 -10000 0 0
GNAI1 0.018 0.063 -10000 0 -0.44 10 10
HBEGF 0.076 0.21 0.31 169 -0.53 22 191
cAMP biosynthetic process 0.006 0.073 -10000 0 -0.23 43 43
SRC 0.028 0.17 0.22 6 -0.49 28 34
PI3K 0.035 0.031 -10000 0 -0.32 4 4
GNB1 0.025 0.006 -10000 0 -10000 0 0
G13/GDP/Gbeta gamma 0.013 0.1 -10000 0 -0.32 39 39
SOS1 0.027 0.002 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1 -0.03 0.12 -10000 0 -0.39 39 39
Gs family/GTP 0.012 0.077 -10000 0 -0.24 43 43
EntrezGene:2778 0 0 -10000 0 -10000 0 0
RAS family/GTP 0.04 0.054 -10000 0 -0.3 12 12
vasodilation -0.021 0.16 0.23 1 -0.46 47 48
mol:DAG -0.024 0.099 -10000 0 -0.4 25 25
Gs family/GDP/Gbeta gamma -0.009 0.098 -10000 0 -0.32 39 39
MSN -0.034 0.076 0.21 5 -0.37 11 16
Gq family/GTP -0.004 0.098 -10000 0 -0.43 22 22
mol:PI-3-4-5-P3 -0.011 0.2 -10000 0 -0.73 40 40
NRAS 0.018 0.059 -10000 0 -0.44 9 9
mol:E2 0 0 -10000 0 -10000 0 0
cell adhesion 0.021 0.16 0.46 47 -0.23 1 48
GRB2/SOS1 0.039 0.007 -10000 0 -10000 0 0
RhoA/GDP 0 0.1 -10000 0 -0.34 39 39
NOS3 -0.026 0.18 -10000 0 -0.52 45 45
GNA11 0.024 0.035 -10000 0 -0.44 3 3
MAPKKK cascade 0.013 0.17 0.34 1 -0.52 40 41
E2/ER alpha (dimer)/PELP1/Src 0.035 0.16 0.26 17 -0.47 29 46
ruffle organization -0.032 0.071 0.21 5 -0.37 9 14
ROCK2 -0.032 0.083 0.23 5 -0.44 9 14
GNA14 0.014 0.076 -10000 0 -0.44 15 15
GNA15 0.015 0.074 -10000 0 -0.44 14 14
GNA13 0.024 0.028 -10000 0 -0.44 2 2
MMP9 0.072 0.21 0.37 144 -0.48 26 170
MMP2 0.022 0.17 0.26 12 -0.53 25 37
Neurotrophic factor-mediated Trk receptor signaling

Figure S46.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S46.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CRKL 0.026 0.005 -10000 0 -10000 0 0
RAS family/GTP/Tiam1 -0.016 0.09 -10000 0 -0.27 44 44
NT3 (dimer)/TRKC 0.011 0.1 -10000 0 -0.34 43 43
NT3 (dimer)/TRKB -0.009 0.16 0.2 2 -0.32 112 114
SHC/Grb2/SOS1/GAB1/PI3K 0.02 0.034 -10000 0 -0.25 4 4
RAPGEF1 0.026 0.02 -10000 0 -0.44 1 1
BDNF 0.013 0.084 -10000 0 -0.44 18 18
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
DYNLT1 0.026 0.004 -10000 0 -10000 0 0
NTRK1 0.001 0.11 -10000 0 -0.44 29 29
NTRK2 -0.023 0.17 -10000 0 -0.44 78 78
NTRK3 0.001 0.1 -10000 0 -0.44 26 26
NT-4/5 (dimer)/TRKB 0 0.15 0.2 2 -0.3 102 104
neuron apoptosis 0.072 0.18 0.4 106 -10000 0 106
SHC 2-3/Grb2 -0.079 0.2 -10000 0 -0.44 106 106
SHC1 0.026 0.004 -10000 0 -10000 0 0
SHC2 -0.074 0.19 -10000 0 -0.5 77 77
SHC3 -0.078 0.2 -10000 0 -0.52 78 78
STAT3 (dimer) 0.03 0.013 -10000 0 -0.26 1 1
NT3 (dimer)/TRKA 0.008 0.13 0.2 1 -0.31 74 75
RIN/GDP 0.005 0.078 0.24 9 -0.24 12 21
GIPC1 0.023 0.04 -10000 0 -0.44 4 4
KRAS 0.022 0.044 -10000 0 -0.44 5 5
DNAJA3 -0.04 0.1 0.18 1 -0.27 81 82
RIN/GTP 0.01 0.007 -10000 0 -10000 0 0
CCND1 0.014 0.019 -10000 0 -0.43 1 1
MAGED1 0.026 0.003 -10000 0 -10000 0 0
PTPN11 0.022 0.044 -10000 0 -0.44 5 5
RICS 0 0 -10000 0 -10000 0 0
NT-4/5 (dimer) 0.001 0.034 -10000 0 -0.44 1 1
SHC/GRB2/SOS1 0.051 0.013 -10000 0 -10000 0 0
GRB2 0.026 0.004 -10000 0 -10000 0 0
NGF (dimer)/TRKA/MATK 0.006 0.13 0.2 2 -0.3 80 82
TRKA/NEDD4-2 0.012 0.079 -10000 0 -0.31 30 30
ELMO1 0.023 0.03 -10000 0 -0.44 2 2
RhoG/GTP/ELMO1/DOCK1 0.031 0.025 -10000 0 -0.27 3 3
NGF 0.007 0.091 -10000 0 -0.44 21 21
HRAS 0.026 0.021 -10000 0 -0.44 1 1
DOCK1 0.025 0.02 -10000 0 -0.44 1 1
GAB2 0.025 0.028 -10000 0 -0.44 2 2
RIT2 -0.011 0.014 -10000 0 -10000 0 0
RIT1 0.026 0.004 -10000 0 -10000 0 0
FRS2 0.025 0.028 -10000 0 -0.44 2 2
DNM1 0.023 0.045 -10000 0 -0.44 5 5
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.022 0.011 -10000 0 -10000 0 0
SH2B1 (homopentamer) 0 0 -10000 0 -10000 0 0
RhoG/GTP -0.018 0.11 -10000 0 -0.26 77 77
mol:GDP 0.002 0.11 0.29 11 -0.35 18 29
NGF (dimer) 0.007 0.091 -10000 0 -0.44 21 21
RhoG/GDP 0.017 0.021 -10000 0 -0.32 2 2
RIT1/GDP 0.008 0.08 0.19 10 -0.24 15 25
TIAM1 0.008 0.1 -10000 0 -0.44 26 26
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
BDNF (dimer)/TRKB 0.007 0.13 -10000 0 -0.29 89 89
KIDINS220/CRKL/C3G 0.037 0.018 -10000 0 -0.32 1 1
SHC/RasGAP 0.036 0.023 -10000 0 -0.32 2 2
FRS2 family/SHP2 0.049 0.04 -10000 0 -0.31 6 6
SHC/GRB2/SOS1/GAB1 0.064 0.019 -10000 0 -10000 0 0
RIT1/GTP 0.019 0.003 -10000 0 -10000 0 0
NT3 (dimer) 0.008 0.09 -10000 0 -0.44 21 21
RAP1/GDP 0.005 0.067 0.14 2 -0.21 15 17
KIDINS220/CRKL 0.025 0.005 -10000 0 -10000 0 0
BDNF (dimer) 0.013 0.084 -10000 0 -0.44 18 18
ubiquitin-dependent protein catabolic process 0.013 0.094 -10000 0 -0.27 50 50
Schwann cell development -0.022 0.025 -10000 0 -10000 0 0
EHD4 0.025 0.007 -10000 0 -10000 0 0
FRS2 family/GRB2/SOS1 0.063 0.028 -10000 0 -0.25 3 3
FRS2 family/SHP2/CRK family/C3G/GAB2 0.002 0.062 -10000 0 -0.32 9 9
RAP1B 0.027 0.002 -10000 0 -10000 0 0
RAP1A 0.025 0.02 -10000 0 -0.44 1 1
CDC42/GTP -0.02 0.12 -10000 0 -0.27 91 91
ABL1 0.026 0.02 -10000 0 -0.44 1 1
SH2B family/GRB2/SOS1 0.039 0.007 -10000 0 -10000 0 0
Rap1/GTP -0.014 0.1 -10000 0 -0.41 19 19
STAT3 0.03 0.013 -10000 0 -0.26 1 1
axon guidance -0.03 0.11 -10000 0 -0.26 87 87
MAPK3 -0.054 0.097 0.18 8 -0.28 77 85
MAPK1 -0.055 0.097 0.18 6 -0.28 79 85
CDC42/GDP 0.011 0.087 0.23 14 -0.25 14 28
NTF3 0.008 0.09 -10000 0 -0.44 21 21
NTF4 0.001 0.034 -10000 0 -0.44 1 1
NGF (dimer)/TRKA/FAIM 0.021 0.1 -10000 0 -0.28 54 54
PI3K 0.035 0.031 -10000 0 -0.32 4 4
FRS3 0.025 0.02 -10000 0 -0.44 1 1
FAIM 0.022 0.044 -10000 0 -0.44 5 5
GAB1 0.026 0.005 -10000 0 -10000 0 0
RASGRF1 -0.052 0.12 -10000 0 -0.27 105 105
SOS1 0.027 0.002 -10000 0 -10000 0 0
MCF2L -0.031 0.071 0.16 1 -0.29 35 36
RGS19 0.012 0.041 -10000 0 -0.44 4 4
CDC42 0.022 0.04 -10000 0 -0.44 4 4
RAS family/GTP 0.003 0.095 0.5 1 -0.46 10 11
Rac1/GDP 0.006 0.078 0.23 8 -0.24 15 23
NGF (dimer)/TRKA/GRIT 0.009 0.09 -10000 0 -0.27 50 50
neuron projection morphogenesis -0.024 0.13 -10000 0 -0.65 11 11
NGF (dimer)/TRKA/NEDD4-2 0.013 0.095 -10000 0 -0.27 50 50
MAP2K1 -0.012 0.036 0.18 17 -0.24 2 19
NGFR 0 0.12 -10000 0 -0.44 40 40
NGF (dimer)/TRKA/GIPC/GAIP -0.006 0.073 -10000 0 -0.24 42 42
RAS family/GTP/PI3K 0.012 0.065 -10000 0 -0.35 13 13
FRS2 family/SHP2/GRB2/SOS1 0.071 0.042 -10000 0 -0.27 6 6
NRAS 0.018 0.059 -10000 0 -0.44 9 9
GRB2/SOS1 0.039 0.007 -10000 0 -10000 0 0
PRKCI 0.024 0.034 -10000 0 -0.44 3 3
ChemicalAbstracts:146-91-8 0 0 -10000 0 -10000 0 0
RAC1 0.024 0.008 -10000 0 -10000 0 0
PRKCZ 0.025 0.021 -10000 0 -0.44 1 1
MAPKKK cascade -0.069 0.2 -10000 0 -0.55 74 74
RASA1 0.024 0.028 -10000 0 -0.44 2 2
TRKA/c-Abl 0.021 0.082 -10000 0 -0.32 30 30
SQSTM1 0.026 0.004 -10000 0 -10000 0 0
BDNF (dimer)/TRKB/GIPC 0.021 0.13 -10000 0 -0.27 90 90
NGF (dimer)/TRKA/p62/Atypical PKCs 0.043 0.097 -10000 0 -0.24 53 53
MATK -0.003 0.12 -10000 0 -0.44 41 41
NEDD4L 0.019 0.023 -10000 0 -0.44 1 1
RAS family/GDP -0.018 0.05 -10000 0 -0.19 19 19
NGF (dimer)/TRKA -0.032 0.11 -10000 0 -0.28 82 82
Rac1/GTP -0.044 0.094 -10000 0 -0.24 69 69
FRS2 family/SHP2/CRK family 0.059 0.048 -10000 0 -0.28 6 6
Caspase cascade in apoptosis

Figure S47.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S47.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TOP1 -0.028 0.11 -10000 0 -0.37 31 31
ACTA1 -0.04 0.11 -10000 0 -0.35 43 43
NUMA1 -0.026 0.12 -10000 0 -0.45 28 28
SPTAN1 -0.04 0.11 0.2 2 -0.35 42 44
LIMK1 -0.033 0.11 0.28 3 -0.34 42 45
BIRC3 0.016 0.075 -10000 0 -0.44 14 14
BIRC2 0.015 0.071 -10000 0 -0.44 13 13
BAX 0.025 0.02 -10000 0 -0.44 1 1
CASP10 -0.041 0.083 0.22 1 -0.31 44 45
CRMA 0 0 -10000 0 -10000 0 0
XIAP 0.026 0.02 -10000 0 -0.44 1 1
PTK2 -0.024 0.11 -10000 0 -0.42 23 23
DIABLO 0.026 0.003 -10000 0 -10000 0 0
apoptotic nuclear changes -0.039 0.11 0.2 2 -0.35 42 44
response to UV 0 0 -10000 0 -10000 0 0
CRADD 0.026 0.003 -10000 0 -10000 0 0
GSN -0.042 0.11 0.2 2 -0.36 44 46
MADD 0.026 0.003 -10000 0 -10000 0 0
TFAP2A -0.053 0.21 -10000 0 -0.54 86 86
BID -0.014 0.057 0.14 1 -0.2 44 45
MAP3K1 -0.017 0.087 -10000 0 -0.41 20 20
TRADD 0.026 0.003 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
APAF-1/Pro-Caspase 9 0.035 0.031 -10000 0 -0.32 4 4
mol:Activated DNA 0 0 -10000 0 -10000 0 0
ARHGDIB -0.039 0.11 0.22 3 -0.35 45 48
CASP9 0.024 0.021 -10000 0 -0.44 1 1
DNA repair 0.002 0.041 0.21 2 -0.16 5 7
neuron apoptosis -0.022 0.17 -10000 0 -0.68 33 33
mol:NAD 0 0 -10000 0 -10000 0 0
DNA fragmentation during apoptosis -0.035 0.12 -10000 0 -0.37 47 47
APAF1 0.024 0.034 -10000 0 -0.44 3 3
CASP6 -0.021 0.17 0.34 1 -0.86 18 19
TRAF2 0.025 0.02 -10000 0 -0.44 1 1
ICAD/CAD -0.041 0.1 -10000 0 -0.34 42 42
CASP7 0.005 0.063 0.28 7 -0.24 11 18
KRT18 0.011 0.045 -10000 0 -0.52 2 2
apoptosis -0.045 0.12 0.35 1 -0.44 28 29
DFFA -0.039 0.11 -10000 0 -0.35 43 43
DFFB -0.04 0.11 -10000 0 -0.35 42 42
PARP1 -0.002 0.042 0.16 5 -0.21 2 7
actin filament polymerization 0.035 0.11 0.32 42 -0.29 2 44
TNF 0.011 0.086 -10000 0 -0.44 19 19
CYCS -0.011 0.065 0.18 1 -0.27 22 23
SATB1 -0.035 0.16 -10000 0 -0.81 18 18
SLK -0.047 0.11 0.36 1 -0.34 51 52
p15 BID/BAX -0.008 0.065 -10000 0 -0.18 55 55
CASP2 0.009 0.06 0.2 17 -0.24 4 21
JNK cascade 0.017 0.086 0.41 20 -10000 0 20
CASP3 -0.039 0.11 -10000 0 -0.36 46 46
LMNB2 0.004 0.11 0.38 3 -0.46 18 21
RIPK1 0.026 0.004 -10000 0 -10000 0 0
CASP4 0.024 0.029 -10000 0 -0.44 2 2
Mammalian IAPs/DIABLO 0.053 0.081 -10000 0 -0.36 19 19
negative regulation of DNA binding -0.052 0.21 -10000 0 -0.53 86 86
stress fiber formation -0.047 0.11 0.36 1 -0.33 51 52
GZMB -0.043 0.097 0.23 1 -0.36 43 44
CASP1 0 0.061 -10000 0 -0.3 23 23
LMNB1 0.001 0.12 0.38 3 -0.49 17 20
APP -0.023 0.18 -10000 0 -0.69 33 33
TNFRSF1A 0.026 0.005 -10000 0 -10000 0 0
response to stress 0 0 -10000 0 -10000 0 0
CASP8 -0.006 0.013 -10000 0 -0.32 1 1
VIM -0.034 0.12 -10000 0 -0.45 27 27
LMNA 0.011 0.078 0.37 3 -0.3 17 20
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD/PIDD 0.007 0.056 -10000 0 -0.25 5 5
LRDD 0 0 -10000 0 -10000 0 0
SREBF1 -0.037 0.11 -10000 0 -0.35 43 43
APAF-1/Caspase 9 -0.013 0.15 0.41 1 -0.61 31 32
nuclear fragmentation during apoptosis -0.026 0.12 -10000 0 -0.44 28 28
CFL2 -0.035 0.11 0.3 2 -0.33 42 44
GAS2 -0.056 0.12 0.22 1 -0.33 53 54
positive regulation of apoptosis 0.008 0.1 0.34 4 -0.43 19 23
PRF1 0.014 0.087 -10000 0 -0.44 19 19
Syndecan-2-mediated signaling events

Figure S48.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S48.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Syndecan-2/Fibronectin 0.001 0.095 0.2 3 -0.29 48 51
EPHB2 0.018 0.059 -10000 0 -0.44 9 9
Syndecan-2/TACI 0.003 0.074 0.2 1 -0.26 38 39
LAMA1 -0.001 0.11 -10000 0 -0.44 30 30
Syndecan-2/alpha2 ITGB1 0.031 0.06 0.19 1 -0.24 19 20
HRAS 0.026 0.021 -10000 0 -0.44 1 1
Syndecan-2/CASK 0.001 0.038 -10000 0 -0.25 12 12
ITGA5 0.026 0.036 -10000 0 -0.44 3 3
BAX -0.011 0.056 -10000 0 -1.1 1 1
EPB41 0.022 0.04 -10000 0 -0.44 4 4
positive regulation of cell-cell adhesion 0.011 0.052 -10000 0 -0.24 21 21
LAMA3 0.018 0.054 -10000 0 -0.44 7 7
EZR 0.026 0.004 -10000 0 -10000 0 0
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
CAV2 0.022 0.05 -10000 0 -0.44 6 6
Syndecan-2/MMP2 0.01 0.076 -10000 0 -0.33 23 23
RP11-540L11.1 0 0 -10000 0 -10000 0 0
alpha2 ITGB1 0.035 0.037 -10000 0 -0.32 6 6
dendrite morphogenesis 0.011 0.056 -10000 0 -0.27 20 20
Syndecan-2/GM-CSF -0.002 0.094 0.2 5 -0.27 58 63
determination of left/right symmetry 0.002 0.045 -10000 0 -0.3 12 12
Syndecan-2/PKC delta 0.017 0.042 -10000 0 -0.26 12 12
GNB2L1 0.026 0.005 -10000 0 -10000 0 0
MAPK3 -0.005 0.1 0.19 58 -0.24 59 117
MAPK1 -0.003 0.1 0.19 59 -0.24 57 116
Syndecan-2/RACK1 0.028 0.043 -10000 0 -0.24 12 12
NF1 0.023 0.035 -10000 0 -0.44 3 3
FGFR/FGF/Syndecan-2 0.002 0.045 -10000 0 -0.3 12 12
ITGA2 0.021 0.048 -10000 0 -0.44 6 6
MAPK8 -0.001 0.043 0.22 1 -0.27 13 14
Syndecan-2/alpha2/beta1 Integrin 0.019 0.081 -10000 0 -0.24 42 42
Syndecan-2/Kininogen -0.005 0.1 0.2 12 -0.27 67 79
ITGB1 0.027 0.002 -10000 0 -10000 0 0
SRC -0.003 0.05 0.18 22 -0.26 8 30
Syndecan-2/CASK/Protein 4.1 0.013 0.042 -10000 0 -0.23 15 15
extracellular matrix organization 0.013 0.056 -10000 0 -0.29 17 17
actin cytoskeleton reorganization 0.001 0.095 0.2 3 -0.29 48 51
Syndecan-2/Caveolin-2/Ras 0.028 0.05 -10000 0 -0.25 14 14
Syndecan-2/Laminin alpha3 0.012 0.049 -10000 0 -0.26 16 16
Syndecan-2/RasGAP 0.038 0.047 -10000 0 -0.23 13 13
alpha5/beta1 Integrin 0.039 0.028 -10000 0 -0.32 3 3
PRKCD 0.026 0.004 -10000 0 -10000 0 0
Syndecan-2 dimer 0.012 0.056 -10000 0 -0.27 20 20
GO:0007205 0.002 0.006 -10000 0 -0.13 1 1
DNA mediated transformation 0 0 -10000 0 -10000 0 0
Syndecan-2/RasGAP/Src 0.013 0.042 0.18 1 -0.26 9 10
RHOA 0.025 0.02 -10000 0 -0.44 1 1
SDCBP 0.015 0.062 -10000 0 -0.44 10 10
TNFRSF13B -0.002 0.11 -10000 0 -0.44 29 29
RASA1 0.024 0.028 -10000 0 -0.44 2 2
alpha2/beta1 Integrin 0.035 0.037 -10000 0 -0.32 6 6
Syndecan-2/Synbindin 0.017 0.042 -10000 0 -0.26 12 12
TGFB1 0.019 0.06 -10000 0 -0.44 9 9
CASP3 0.025 0.067 0.19 62 -0.23 11 73
FN1 -0.01 0.14 -10000 0 -0.44 52 52
Syndecan-2/IL8 -0.001 0.1 0.21 6 -0.29 55 61
SDC2 0.002 0.046 -10000 0 -0.3 12 12
KNG1 -0.027 0.15 -10000 0 -0.44 64 64
Syndecan-2/Neurofibromin 0.016 0.044 -10000 0 -0.26 13 13
TRAPPC4 0.026 0.004 -10000 0 -10000 0 0
CSF2 -0.018 0.15 -10000 0 -0.44 57 57
Syndecan-2/TGFB1 0.014 0.056 -10000 0 -0.29 17 17
Syndecan-2/Syntenin/PI-4-5-P2 0.011 0.052 -10000 0 -0.25 21 21
Syndecan-2/Ezrin 0.029 0.043 -10000 0 -0.24 12 12
PRKACA 0.027 0.072 0.19 71 -0.24 13 84
angiogenesis -0.001 0.099 0.21 6 -0.28 55 61
MMP2 0.01 0.095 -10000 0 -0.44 23 23
IL8 -0.017 0.15 -10000 0 -0.44 61 61
calcineurin-NFAT signaling pathway 0.003 0.074 0.2 1 -0.26 38 39
IFN-gamma pathway

Figure S49.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S49.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 0.034 0.096 -10000 0 -0.24 54 54
positive regulation of NF-kappaB transcription factor activity 0 0.001 -10000 0 -10000 0 0
CRKL 0.026 0.005 -10000 0 -10000 0 0
STAT1 (dimer)/Cbp/p300 0.01 0.093 0.29 1 -0.38 9 10
IFN-gammaR/JAK1/JAK1/JAK2/JAK2 0.033 0.067 -10000 0 -0.3 15 15
antigen processing and presentation of peptide antigen via MHC class I -0.016 0.074 -10000 0 -0.23 26 26
CaM/Ca2+ 0.033 0.092 -10000 0 -0.23 53 53
RAP1A 0.025 0.02 -10000 0 -0.44 1 1
STAT1 (dimer)/SHP2 -0.003 0.088 0.21 1 -0.24 53 54
AKT1 -0.034 0.078 0.28 4 -0.35 10 14
MAP2K1 -0.037 0.085 0.29 3 -0.25 48 51
MAP3K11 -0.033 0.076 0.26 4 -0.23 51 55
IFNGR1 0.021 0.021 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
CaM/Ca2+/CAMKII -0.018 0.13 -10000 0 -0.4 37 37
Rap1/GTP -0.041 0.055 -10000 0 -0.3 7 7
CRKL/C3G 0.037 0.018 -10000 0 -0.32 1 1
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 /TC-PTP 0.036 0.099 -10000 0 -0.24 52 52
CEBPB 0 0.16 0.37 3 -0.48 30 33
STAT3 0.026 0.004 -10000 0 -10000 0 0
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 0.021 0.21 -10000 0 -1.1 16 16
STAT1 -0.033 0.081 0.18 13 -0.24 53 66
CALM1 0.025 0.007 -10000 0 -10000 0 0
IFN-gamma (dimer) -0.007 0.12 -10000 0 -0.45 37 37
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
STAT1 (dimer)/PIAS1 -0.004 0.086 0.3 3 -0.23 47 50
CEBPB/PTGES2/Cbp/p300 0.013 0.11 -10000 0 -0.36 20 20
mol:Ca2+ 0.031 0.094 -10000 0 -0.24 54 54
MAPK3 -0.022 0.11 0.38 1 -0.71 8 9
STAT1 (dimer) -0.015 0.1 -10000 0 -0.32 26 26
MAPK1 -0.05 0.19 0.4 1 -0.75 31 32
JAK2 0.01 0.079 -10000 0 -0.46 15 15
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
JAK1 0.02 0.03 -10000 0 -0.49 1 1
CAMK2D 0.023 0.04 -10000 0 -0.44 4 4
DAPK1 -0.003 0.15 0.32 5 -0.55 28 33
SMAD7 -0.009 0.043 0.17 3 -0.18 7 10
CBL/CRKL/C3G 0.008 0.085 0.34 2 -0.22 46 48
PI3K 0.03 0.098 -10000 0 -0.24 53 53
IFNG -0.007 0.12 -10000 0 -0.45 37 37
apoptosis -0.005 0.13 0.33 3 -0.41 36 39
CAMK2G 0.026 0.004 -10000 0 -10000 0 0
STAT3 (dimer) 0.026 0.004 -10000 0 -10000 0 0
CAMK2A 0.007 0.09 -10000 0 -0.44 21 21
CAMK2B 0.007 0.091 -10000 0 -0.44 20 20
FRAP1 -0.033 0.073 0.26 4 -0.33 10 14
PRKCD -0.036 0.079 0.28 4 -0.36 10 14
RAP1B 0.027 0.002 -10000 0 -10000 0 0
negative regulation of cell growth -0.016 0.074 -10000 0 -0.23 26 26
PTPN2 0.02 0.022 -10000 0 -0.44 1 1
EP300 0.024 0.029 -10000 0 -0.44 2 2
IRF1 -0.033 0.085 0.34 3 -0.38 16 19
STAT1 (dimer)/PIASy -0.005 0.088 0.23 6 -0.24 48 54
SOCS1 -0.011 0.23 -10000 0 -1.3 16 16
mol:GDP 0.005 0.079 0.27 1 -0.22 47 48
CASP1 -0.016 0.061 0.16 4 -0.24 25 29
PTGES2 0.026 0.021 -10000 0 -0.44 1 1
IRF9 0.013 0.055 0.16 10 -0.17 10 20
mol:PI-3-4-5-P3 0.017 0.09 -10000 0 -0.24 53 53
RAP1/GDP 0.007 0.076 -10000 0 -0.32 6 6
CBL -0.032 0.076 0.26 4 -0.23 51 55
MAP3K1 -0.035 0.083 0.18 11 -0.25 52 63
PIAS1 0.025 0.006 -10000 0 -10000 0 0
PIAS4 0.025 0.02 -10000 0 -0.43 1 1
antigen processing and presentation of peptide antigen via MHC class II -0.016 0.074 -10000 0 -0.23 26 26
PTPN11 -0.032 0.076 0.16 13 -0.24 53 66
CREBBP 0.026 0.004 -10000 0 -10000 0 0
RAPGEF1 0.026 0.02 -10000 0 -0.44 1 1
Retinoic acid receptors-mediated signaling

Figure S50.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S50.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.026 0.005 -10000 0 -10000 0 0
HDAC3 0.026 0.004 -10000 0 -10000 0 0
VDR 0.026 0.02 -10000 0 -0.44 1 1
Cbp/p300/PCAF 0.04 0.06 -10000 0 -0.28 17 17
EP300 0.024 0.029 -10000 0 -0.44 2 2
RARs/AIB1/Cbp/p300/PCAF/9cRA -0.003 0.062 -10000 0 -0.28 17 17
KAT2B 0.013 0.078 -10000 0 -0.44 16 16
MAPK14 0.026 0.003 -10000 0 -10000 0 0
AKT1 -0.007 0.078 0.2 21 -0.26 16 37
RAR alpha/9cRA/Cyclin H 0.008 0.1 -10000 0 -0.33 5 5
mol:9cRA 0 0 -10000 0 -10000 0 0
RARs/Src-1/Cbp/p300/PCAF/9cRA -0.005 0.08 0.18 3 -0.3 23 26
CDC2 0 0.002 -10000 0 -10000 0 0
response to UV 0 0.003 -10000 0 -10000 0 0
RAR alpha/Jnk1 0 0.075 -10000 0 -0.18 76 76
NCOR2 0.024 0.035 -10000 0 -0.44 3 3
VDR/VDR/Vit D3 0.019 0.014 -10000 0 -0.32 1 1
RXRs/RARs/NRIP1/9cRA -0.038 0.16 0.3 1 -0.4 78 79
NCOA2 0.018 0.049 -10000 0 -0.44 6 6
NCOA3 0.015 0.013 -10000 0 -10000 0 0
NCOA1 0.026 0.02 -10000 0 -0.44 1 1
VDR/VDR/DNA 0.026 0.02 -10000 0 -0.44 1 1
RARG 0.021 0.049 -10000 0 -0.44 6 6
RAR gamma1/9cRA 0.032 0.032 -10000 0 -0.27 6 6
MAPK3 0.025 0.021 -10000 0 -0.44 1 1
MAPK1 0.025 0.006 -10000 0 -10000 0 0
MAPK8 0.025 0.022 -10000 0 -0.44 1 1
mol:Vit D3 0 0 -10000 0 -10000 0 0
RXRs/VDR/DNA/Vit D3 -0.021 0.15 -10000 0 -0.39 78 78
RARA -0.014 0.082 0.15 6 -0.22 73 79
negative regulation of phosphoinositide 3-kinase cascade 0 0 -10000 0 -10000 0 0
RARs/TIF2/Cbp/p300/PCAF/9cRA -0.005 0.082 0.18 3 -0.34 20 23
PRKCA 0.025 0.023 -10000 0 -0.44 1 1
RXRs/RARs/NRIP1/9cRA/HDAC1 -0.032 0.16 0.34 2 -0.39 78 80
RXRG -0.02 0.11 0.17 3 -0.29 72 75
RXRA -0.014 0.075 -10000 0 -0.19 74 74
RXRB -0.019 0.11 0.17 4 -0.29 72 76
VDR/Vit D3/DNA 0.019 0.014 -10000 0 -0.32 1 1
RBP1 0.016 0.1 -10000 0 -0.44 26 26
CRBP1/9-cic-RA 0.012 0.074 -10000 0 -0.32 26 26
RARB 0.019 0.063 -10000 0 -0.44 10 10
PRKCG -0.022 0.16 -10000 0 -0.44 73 73
MNAT1 0.024 0.021 -10000 0 -0.44 1 1
RAR alpha/RXRs -0.038 0.16 0.26 1 -0.4 81 82
RXRs/RARs/SMRT(N-CoR2)/9cRA -0.028 0.14 0.24 1 -0.34 71 72
proteasomal ubiquitin-dependent protein catabolic process 0.014 0.093 0.26 7 -0.29 16 23
RXRs/RARs/NRIP1/9cRA/HDAC3 -0.031 0.16 0.34 2 -0.39 77 79
positive regulation of DNA binding 0 0.091 -10000 0 -0.31 5 5
NRIP1 -0.036 0.19 -10000 0 -1 11 11
RXRs/RARs -0.026 0.15 0.28 2 -0.36 80 82
RXRs/RXRs/DNA/9cRA -0.037 0.15 -10000 0 -0.39 80 80
PRKACA 0.026 0.003 -10000 0 -10000 0 0
CDK7 0.024 0.028 -10000 0 -0.44 2 2
TFIIH 0.047 0.033 -10000 0 -0.39 2 2
RAR alpha/9cRA 0.024 0.085 0.22 1 -0.33 3 4
CCNH 0.026 0.005 -10000 0 -10000 0 0
CREBBP 0.026 0.004 -10000 0 -10000 0 0
RAR gamma2/9cRA 0.043 0.041 -10000 0 -0.25 8 8
Integrins in angiogenesis

Figure S51.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S51.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR2 homodimer/VEGFA homodimer 0.036 0.028 -10000 0 -0.32 3 3
alphaV beta3 Integrin 0.029 0.098 -10000 0 -0.32 38 38
PTK2 0.011 0.13 0.29 15 -0.44 20 35
IGF1R 0.025 0.021 -10000 0 -0.44 1 1
PI4KB 0.026 0.004 -10000 0 -10000 0 0
MFGE8 0.023 0.041 -10000 0 -0.44 4 4
SRC 0.015 0.023 -10000 0 -0.44 1 1
CDKN1B -0.007 0.1 -10000 0 -0.46 25 25
VEGFA 0.026 0.004 -10000 0 -10000 0 0
ILK -0.006 0.1 -10000 0 -0.45 23 23
ROCK1 0.017 0.049 -10000 0 -0.44 6 6
AKT1 -0.015 0.093 -10000 0 -0.41 25 25
PTK2B -0.02 0.058 0.19 12 -0.25 24 36
alphaV/beta3 Integrin/JAM-A 0.021 0.1 -10000 0 -0.28 52 52
CBL 0.026 0.004 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
alphaV beta3 Integrin/ANGPTL3 0.036 0.065 -10000 0 -0.28 21 21
IGF-1R heterotetramer/IGF1/IRS1/Shp2 0.033 0.1 -10000 0 -0.26 60 60
VEGF/Rho/ROCK/alphaV/beta3 Integrin -0.019 0.1 -10000 0 -0.46 18 18
alphaV/beta3 Integrin/Syndecan-1 0.04 0.067 -10000 0 -0.28 22 22
PI4KA 0.026 0.005 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1 -0.008 0.16 -10000 0 -0.31 106 106
PI4 Kinase 0.037 0.01 -10000 0 -10000 0 0
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
alphaV/beta3 Integrin/Osteopontin 0.001 0.14 -10000 0 -0.29 94 94
RPS6KB1 -0.082 0.13 -10000 0 -0.45 41 41
TLN1 0.025 0.02 -10000 0 -0.44 1 1
MAPK3 -0.051 0.17 -10000 0 -0.56 45 45
GPR124 0.021 0.03 -10000 0 -0.44 2 2
MAPK1 -0.051 0.17 -10000 0 -0.56 45 45
PXN 0.027 0.002 -10000 0 -10000 0 0
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
alphaV/beta3 Integrin/Tumstatin 0.024 0.1 -10000 0 -0.29 54 54
cell adhesion 0.026 0.074 -10000 0 -0.3 25 25
ANGPTL3 -0.002 0.022 -10000 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/Src 0.03 0.033 -10000 0 -0.27 2 2
IGF-1R heterotetramer 0.025 0.021 -10000 0 -0.44 1 1
Rac1/GDP 0.018 0.006 -10000 0 -10000 0 0
TGFBR2 0.027 0.004 -10000 0 -10000 0 0
ITGB3 0.018 0.066 -10000 0 -0.44 11 11
IGF1 -0.008 0.13 -10000 0 -0.44 47 47
RAC1 0.024 0.008 -10000 0 -10000 0 0
regulation of cell-matrix adhesion 0.032 0.07 -10000 0 -0.29 22 22
apoptosis 0.017 0.065 -10000 0 -0.44 11 11
CD47 0.025 0.028 -10000 0 -0.44 2 2
alphaV/beta3 Integrin/CD47 0.039 0.07 -10000 0 -0.29 22 22
VCL 0.024 0.028 -10000 0 -0.44 2 2
alphaV/beta3 Integrin/Del1 0.017 0.11 -10000 0 -0.33 51 51
CSF1 0.024 0.035 -10000 0 -0.44 3 3
PIK3C2A -0.024 0.15 -10000 0 -0.52 42 42
PI4 Kinase/Pyk2 -0.001 0.091 -10000 0 -0.28 38 38
VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin 0.051 0.069 -10000 0 -0.27 22 22
FAK1/Vinculin 0.027 0.12 0.27 16 -0.38 18 34
alphaV beta3/Integrin/ppsTEM5 0.032 0.071 -10000 0 -0.29 22 22
RHOA 0.025 0.02 -10000 0 -0.44 1 1
VTN 0.008 0.093 -10000 0 -0.44 21 21
BCAR1 0.025 0.029 -10000 0 -0.44 2 2
FGF2 0.009 0.097 -10000 0 -0.44 24 24
F11R -0.026 0.064 0.21 1 -0.32 24 25
alphaV/beta3 Integrin/Lactadherin 0.037 0.073 -10000 0 -0.29 24 24
alphaV/beta3 Integrin/TGFBR2 0.04 0.065 -10000 0 -0.28 21 21
alphaV/beta3 Integrin/c-FMS/Cbl/Cas 0.055 0.056 -10000 0 -0.26 16 16
HSP90AA1 0.024 0.021 -10000 0 -0.44 1 1
alphaV/beta3 Integrin/Talin 0.037 0.061 -10000 0 -0.26 22 22
mol:GDP 0 0 -10000 0 -10000 0 0
FN1 -0.01 0.14 -10000 0 -0.44 52 52
alphaV/beta3 Integrin/Pyk2 0.024 0.065 -10000 0 -0.25 24 24
SDC1 0.026 0.02 -10000 0 -0.44 1 1
VAV3 -0.05 0.084 0.18 4 -0.24 83 87
PTPN11 0.022 0.044 -10000 0 -0.44 5 5
IRS1 0.019 0.059 -10000 0 -0.44 9 9
FAK1/Paxillin 0.027 0.12 0.23 30 -0.37 18 48
cell migration 0.021 0.11 0.2 47 -0.35 18 65
ITGAV 0.017 0.065 -10000 0 -0.44 11 11
PI3K 0.033 0.11 -10000 0 -0.27 54 54
SPP1 -0.031 0.17 -10000 0 -0.44 83 83
KDR 0.024 0.035 -10000 0 -0.44 3 3
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
alphaV/beta3 Integrin/Caspase 8 0.017 0.065 -10000 0 -0.44 11 11
COL4A3 -0.003 0.12 -10000 0 -0.44 35 35
angiogenesis -0.05 0.17 -10000 0 -0.57 45 45
Rac1/GTP -0.016 0.088 -10000 0 -0.23 79 79
EDIL3 -0.008 0.12 -10000 0 -0.44 41 41
cell proliferation 0.04 0.065 -10000 0 -0.28 21 21
Cellular roles of Anthrax toxin

Figure S52.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S52.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ANTXR1 0.001 0.11 -10000 0 -0.44 34 34
ANTXR2 0.023 0.04 -10000 0 -0.44 4 4
negative regulation of myeloid dendritic cell antigen processing and presentation -0.006 0.015 -10000 0 -0.061 38 38
monocyte activation -0.02 0.13 -10000 0 -0.41 53 53
MAP2K2 0.003 0.08 -10000 0 -0.59 10 10
MAP2K1 -0.009 0.019 -10000 0 -0.25 2 2
MAP2K7 -0.009 0.016 -10000 0 -0.23 1 1
MAP2K6 -0.013 0.033 -10000 0 -0.23 10 10
CYAA -0.024 0.055 -10000 0 -0.23 38 38
MAP2K4 -0.007 0.015 -10000 0 -0.23 1 1
IL1B -0.029 0.063 -10000 0 -0.22 48 48
Channel 0.017 0.071 -10000 0 -0.24 38 38
NLRP1 -0.011 0.029 -10000 0 -0.19 9 9
CALM1 0.025 0.007 -10000 0 -10000 0 0
negative regulation of phagocytosis -0.023 0.11 -10000 0 -0.41 40 40
mol:Ca2+ 0 0 -10000 0 -10000 0 0
regulation of endothelial cell proliferation 0.006 0.015 0.061 38 -10000 0 38
MAPK3 -0.009 0.017 0.13 1 -0.23 1 2
MAPK1 -0.009 0.014 -10000 0 -0.1 1 1
PGR -0.023 0.055 -10000 0 -0.24 30 30
PA/Cellular Receptors 0.017 0.078 -10000 0 -0.27 38 38
apoptosis -0.006 0.015 -10000 0 -0.061 38 38
LOC728358 0 0 -10000 0 -10000 0 0
Lethal toxin (unfolded) 0.017 0.067 -10000 0 -0.23 38 38
macrophage activation -0.012 0.017 0.12 1 -0.16 2 3
TNF 0.011 0.086 -10000 0 -0.44 19 19
VCAM1 -0.019 0.13 -10000 0 -0.41 52 52
platelet activation -0.023 0.11 -10000 0 -0.41 40 40
MAPKKK cascade 0.008 0.022 0.13 3 -0.08 5 8
IL18 -0.013 0.032 -10000 0 -0.21 9 9
negative regulation of macrophage activation -0.006 0.015 -10000 0 -0.061 38 38
LEF -0.006 0.015 -10000 0 -0.061 38 38
CASP1 -0.008 0.025 -10000 0 -0.098 30 30
mol:cAMP -0.023 0.11 -10000 0 -0.41 40 40
necrosis -0.006 0.015 -10000 0 -0.061 38 38
intracellular pH reduction 0 0 -10000 0 -10000 0 0
PAGA 0 0 -10000 0 -10000 0 0
Edema toxin (unfolded) 0.017 0.067 -10000 0 -0.23 38 38
mol:Epigallocatechin-3-gallate (EGCG) 0 0 -10000 0 -10000 0 0
Arf6 signaling events

Figure S53.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S53.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CENTA1/KIF3B 0.025 0.028 -10000 0 -0.5 1 1
ARNO/beta Arrestin1-2 0.019 0.086 -10000 0 -0.84 3 3
EGFR 0.02 0.045 -10000 0 -0.44 5 5
EPHA2 0.024 0.029 -10000 0 -0.44 2 2
USP6 0.022 0.023 -10000 0 -0.44 1 1
IQSEC1 0.026 0.004 -10000 0 -10000 0 0
EGFR/EGFR/EGF/EGF -0.004 0.13 -10000 0 -0.32 75 75
ARRB2 0.007 0.004 -10000 0 -10000 0 0
mol:GTP -0.004 0.054 0.13 9 -0.19 20 29
ARRB1 0.025 0.028 -10000 0 -0.44 2 2
FBXO8 0.024 0.021 -10000 0 -0.44 1 1
TSHR 0.016 0.038 -10000 0 -0.44 2 2
EGF -0.029 0.17 -10000 0 -0.44 80 80
somatostatin receptor activity 0 0 0.001 39 -0.001 28 67
ARAP2 0.012 0.081 -10000 0 -0.44 17 17
mol:GDP -0.003 0.091 0.19 11 -0.26 32 43
mol:PI-3-4-5-P3 0 0 0.001 18 -0.001 13 31
ITGA2B 0.007 0.098 -10000 0 -0.44 24 24
ARF6 0.024 0.021 -10000 0 -0.44 1 1
Ephrin A1/EPHA2/NCK1/GIT1 0.058 0.039 -10000 0 -0.3 4 4
ADAP1 0.023 0.021 -10000 0 -0.44 1 1
KIF13B 0.02 0.023 -10000 0 -0.44 1 1
HGF/MET 0.019 0.083 -10000 0 -0.32 31 31
PXN 0.027 0.002 -10000 0 -10000 0 0
ARF6/GTP -0.001 0.1 0.22 30 -0.27 25 55
EGFR/EGFR/EGF/EGF/ARFGEP100 0.011 0.12 -10000 0 -0.27 75 75
ADRB2 0.003 0.1 -10000 0 -0.44 28 28
receptor agonist activity 0 0 0 15 0 21 36
actin filament binding 0 0 0 35 0 29 64
SRC 0.015 0.023 -10000 0 -0.44 1 1
ITGB3 0.018 0.066 -10000 0 -0.44 11 11
GNAQ 0.022 0.044 -10000 0 -0.44 5 5
EFA6/PI-4-5-P2 0 0.001 0.001 47 -0.001 16 63
ARF6/GDP -0.05 0.17 0.21 3 -0.4 81 84
ARF6/GDP/GULP/ACAP1 0.003 0.12 0.23 6 -0.32 31 37
alphaIIb/beta3 Integrin/paxillin/GIT1 0.049 0.08 -10000 0 -0.25 35 35
ACAP1 0.012 0.074 -10000 0 -0.44 14 14
ACAP2 0.018 0.062 -10000 0 -0.44 10 10
LHCGR/beta Arrestin2 0.006 0.028 -10000 0 -10000 0 0
EFNA1 0.026 0.004 -10000 0 -10000 0 0
HGF 0.001 0.11 -10000 0 -0.44 31 31
CYTH3 -0.004 0.019 -10000 0 -0.32 2 2
CYTH2 0.014 0.075 -10000 0 -1 3 3
NCK1 0.025 0.028 -10000 0 -0.44 2 2
fibronectin binding 0 0 0 36 0 24 60
endosomal lumen acidification 0 0 0 40 0 24 64
microtubule-based process 0 0 -10000 0 0 1 1
GULP1 -0.005 0.12 -10000 0 -0.44 41 41
GNAQ/ARNO 0.027 0.074 -10000 0 -0.93 3 3
mol:Phosphatidic acid 0 0 0 10 -10000 0 10
PIP3-E 0 0 0 10 0 12 22
MET 0.025 0.021 -10000 0 -0.44 1 1
GNA14 0.014 0.076 -10000 0 -0.44 15 15
GNA15 0.015 0.074 -10000 0 -0.44 14 14
GIT1 0.025 0.02 -10000 0 -0.44 1 1
mol:PI-4-5-P2 0 0 0.001 45 -0.001 19 64
GNA11 0.024 0.035 -10000 0 -0.44 3 3
LHCGR -0.007 0.018 -10000 0 -10000 0 0
AGTR1 -0.017 0.14 -10000 0 -0.44 52 52
desensitization of G-protein coupled receptor protein signaling pathway 0.006 0.028 -10000 0 -10000 0 0
IPCEF1/ARNO 0.012 0.11 -10000 0 -0.91 3 3
alphaIIb/beta3 Integrin 0.02 0.089 -10000 0 -0.32 35 35
Presenilin action in Notch and Wnt signaling

Figure S54.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S54.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Delta 1/NOTCH/NOTCH(cleaved) 0.01 0.13 -10000 0 -0.43 42 42
HDAC1 0.024 0.006 -10000 0 -10000 0 0
AES 0.025 0.02 -10000 0 -0.44 1 1
FBXW11 0.026 0.004 -10000 0 -10000 0 0
DTX1 0.015 0.076 -10000 0 -0.44 15 15
LRP6/FZD1 0.034 0.032 -10000 0 -0.32 4 4
TLE1 0.023 0.04 -10000 0 -0.44 4 4
AP1 -0.03 0.1 -10000 0 -0.25 94 94
NCSTN 0.026 0.004 -10000 0 -10000 0 0
ADAM10 0.022 0.04 -10000 0 -0.44 4 4
Beta Catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 0.022 0.098 -10000 0 -0.66 9 9
NICD/RBPSUH 0.009 0.12 -10000 0 -0.42 42 42
WIF1 -0.034 0.17 -10000 0 -0.44 78 78
NOTCH1 -0.008 0.12 -10000 0 -0.43 42 42
PSENEN 0.025 0.02 -10000 0 -0.44 1 1
KREMEN2 0.022 0.072 -10000 0 -0.44 12 12
DKK1 -0.024 0.16 -10000 0 -0.44 69 69
beta catenin/beta TrCP1 0.041 0.074 0.28 3 -10000 0 3
APH1B 0.022 0.04 -10000 0 -0.44 4 4
APH1A 0.026 0.004 -10000 0 -10000 0 0
AXIN1 -0.011 0.077 -10000 0 -0.45 9 9
CtBP/CBP/TCF1/TLE1/AES 0.009 0.054 -10000 0 -0.32 9 9
PSEN1 0.025 0.007 -10000 0 -10000 0 0
FOS 0.013 0.082 -10000 0 -0.44 17 17
JUN 0.023 0.04 -10000 0 -0.44 4 4
MAP3K7 0.025 0.004 -10000 0 -10000 0 0
CTNNB1 0.029 0.075 0.26 5 -10000 0 5
MAPK3 0.025 0.02 -10000 0 -0.44 1 1
DKK2/LRP6/Kremen 2 0.013 0.12 -10000 0 -0.28 74 74
HNF1A 0.022 0.044 -10000 0 -0.44 5 5
CTBP1 0.024 0.02 -10000 0 -0.44 1 1
MYC 0.013 0.12 -10000 0 -1.3 5 5
NKD1 -0.032 0.17 -10000 0 -0.44 80 80
FZD1 0.024 0.029 -10000 0 -0.44 2 2
NOTCH1 precursor/Deltex homolog 1 0.004 0.13 -10000 0 -0.41 42 42
apoptosis -0.03 0.1 -10000 0 -0.25 94 94
Delta 1/NOTCHprecursor 0.007 0.13 -10000 0 -0.43 42 42
DLL1 0.02 0.057 -10000 0 -0.44 8 8
PPARD 0.023 0.08 -10000 0 -0.87 4 4
Gamma Secretase 0.065 0.041 -10000 0 -0.24 5 5
APC -0.04 0.14 -10000 0 -0.43 49 49
DVL1 -0.01 0.085 -10000 0 -0.32 30 30
CSNK2A1 0.021 0.011 -10000 0 -10000 0 0
MAP3K7IP1 -0.001 0.002 -10000 0 -10000 0 0
DKK1/LRP6/Kremen 2 0.013 0.12 -10000 0 -0.28 81 81
LRP6 0.024 0.028 -10000 0 -0.44 2 2
CSNK1A1 0.025 0.028 -10000 0 -0.44 2 2
NLK 0.01 0.005 -10000 0 -10000 0 0
CCND1 0.013 0.14 -10000 0 -0.93 10 10
WNT1 0.014 0.033 -10000 0 -0.44 1 1
Axin1/APC/beta catenin -0.003 0.12 0.4 3 -0.42 22 25
DKK2 -0.022 0.15 -10000 0 -0.44 62 62
NOTCH1 precursor/DVL1 -0.016 0.16 -10000 0 -0.49 47 47
GSK3B 0.025 0.028 -10000 0 -0.44 2 2
FRAT1 0.024 0.021 -10000 0 -0.44 1 1
NOTCH/Deltex homolog 1 0.007 0.13 -10000 0 -0.42 42 42
PPP2R5D 0.043 0.087 0.25 72 -0.27 6 78
MAPK1 0.025 0.006 -10000 0 -10000 0 0
WNT1/LRP6/FZD1 0.026 0.12 -10000 0 -0.26 78 78
RBPJ 0.025 0.021 -10000 0 -0.44 1 1
CREBBP 0.027 0.006 -10000 0 -10000 0 0
Ceramide signaling pathway

Figure S55.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S55.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPHK2 -0.012 0.022 0.23 1 -0.32 2 3
MAP4K4 0.001 0.058 -10000 0 -0.34 5 5
BAG4 0.022 0.022 -10000 0 -0.44 1 1
PKC zeta/ceramide -0.013 0.075 -10000 0 -0.21 55 55
NFKBIA 0.025 0.007 -10000 0 -10000 0 0
BIRC3 0.016 0.074 -10000 0 -0.44 14 14
BAX -0.003 0.044 -10000 0 -0.31 7 7
RIPK1 0.026 0.004 -10000 0 -10000 0 0
AKT1 -0.006 0.02 -10000 0 -0.38 1 1
BAD -0.029 0.069 -10000 0 -0.21 56 56
SMPD1 0.012 0.056 0.2 8 -0.18 20 28
RB1 0.007 0.098 0.19 83 -0.21 44 127
FADD/Caspase 8 0.008 0.057 0.2 2 -0.32 4 6
MAP2K4 -0.031 0.068 -10000 0 -0.21 55 55
NSMAF 0.023 0.009 -10000 0 -10000 0 0
response to UV 0 0 -10000 0 -10000 0 0
RAF1 -0.026 0.07 0.18 12 -0.2 54 66
EGF -0.03 0.17 -10000 0 -0.44 80 80
mol:ceramide -0.027 0.073 0.13 2 -0.22 56 58
MADD 0.026 0.003 -10000 0 -10000 0 0
response to oxidative stress 0 0 -10000 0 -10000 0 0
mol:Free Fatty acid -0.009 0.018 0.23 1 -0.32 1 2
ASAH1 0.02 0.012 -10000 0 -10000 0 0
negative regulation of cell cycle 0.006 0.098 0.19 83 -0.21 44 127
cell proliferation -0.017 0.092 0.19 2 -0.22 50 52
BID -0.01 0.14 -10000 0 -0.58 27 27
MAP3K1 -0.031 0.071 -10000 0 -0.21 61 61
EIF2A -0.039 0.074 0.17 2 -0.21 65 67
TRADD 0.026 0.003 -10000 0 -10000 0 0
CRADD 0.026 0.003 -10000 0 -10000 0 0
MAPK3 -0.024 0.066 0.17 11 -0.25 15 26
response to heat 0 0 -10000 0 -10000 0 0
MAPK1 -0.029 0.068 0.17 9 -0.26 15 24
Cathepsin D/ceramide -0.012 0.076 -10000 0 -0.21 56 56
FADD 0.004 0.053 0.2 2 -0.3 3 5
KSR1 -0.025 0.072 0.19 10 -0.21 55 65
MAPK8 -0.027 0.074 -10000 0 -0.23 33 33
PRKRA -0.029 0.069 -10000 0 -0.21 57 57
PDGFA 0.024 0.022 -10000 0 -0.44 1 1
TRAF2 0.025 0.02 -10000 0 -0.44 1 1
IGF1 -0.008 0.13 -10000 0 -0.44 47 47
mol:GD3 0 0 -10000 0 -10000 0 0
ganglioside biosynthetic process -0.027 0.073 0.13 2 -0.22 56 58
CTSD 0.026 0.021 -10000 0 -0.44 1 1
regulation of nitric oxide biosynthetic process 0.037 0.017 -10000 0 -0.32 1 1
response to radiation 0 0 -10000 0 -10000 0 0
ERK1/PKC delta -0.017 0.098 0.2 2 -0.24 49 51
PRKCD 0.026 0.004 -10000 0 -10000 0 0
PRKCZ 0.025 0.021 -10000 0 -0.44 1 1
mol:GW4869 0 0 -10000 0 -10000 0 0
mol:sphingosine -0.009 0.018 0.23 1 -0.32 1 2
RelA/NF kappa B1 0.037 0.017 -10000 0 -0.32 1 1
mol:glutathione 0 0 -10000 0 -10000 0 0
PAWR 0.026 0.02 -10000 0 -0.44 1 1
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD 0.006 0.058 -10000 0 -0.32 5 5
TNFR1A/BAG4/TNF-alpha 0.035 0.06 -10000 0 -0.27 18 18
mol:Sphingosine-1-phosphate -0.012 0.022 0.23 1 -0.32 2 3
MAP2K1 -0.028 0.067 0.18 5 -0.24 18 23
mol:C11AG 0 0 -10000 0 -10000 0 0
RELA 0.026 0.004 -10000 0 -10000 0 0
CYCS 0.013 0.059 0.16 10 -0.18 15 25
TNFRSF1A 0.026 0.005 -10000 0 -10000 0 0
NFKB1 0.025 0.02 -10000 0 -0.44 1 1
TNFR1A/BAG4 0.033 0.021 -10000 0 -0.32 1 1
EIF2AK2 -0.037 0.074 -10000 0 -0.21 71 71
TNF-alpha/TNFR1A/FAN 0.037 0.057 -10000 0 -0.27 16 16
response to hydrogen peroxide 0 0 -10000 0 -10000 0 0
CASP8 0.014 0.068 -10000 0 -0.36 9 9
MAP2K2 -0.028 0.066 0.17 12 -0.23 21 33
SMPD3 0.007 0.065 0.16 2 -0.3 15 17
TNF 0.011 0.086 -10000 0 -0.44 19 19
PKC zeta/PAR4 0.036 0.023 -10000 0 -0.32 2 2
mol:PHOSPHOCHOLINE 0.025 0.08 0.2 73 -0.13 32 105
NF kappa B1/RelA/I kappa B alpha 0.066 0.036 -10000 0 -0.25 3 3
AIFM1 0.012 0.061 0.15 7 -0.19 9 16
BCL2 0.015 0.05 -10000 0 -0.44 6 6
FAS signaling pathway (CD95)

Figure S56.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S56.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPTAN1 -0.007 0.04 0.21 8 -0.24 2 10
RFC1 -0.009 0.041 0.21 6 -0.3 3 9
PRKDC 0.007 0.069 0.23 40 -0.24 2 42
RIPK1 0.027 0.005 -10000 0 -10000 0 0
CASP7 -0.006 0.1 -10000 0 -0.57 15 15
FASLG/FAS/FADD/FAF1 0.009 0.093 0.2 54 -0.26 31 85
MAP2K4 -0.044 0.14 0.24 1 -0.34 72 73
mol:ceramide -0.017 0.11 -10000 0 -0.34 46 46
GSN -0.008 0.044 0.21 9 -0.25 4 13
FASLG/FAS/FADD/FAF1/Caspase 8 0 0.1 -10000 0 -0.32 32 32
FAS 0.015 0.055 -10000 0 -0.45 7 7
BID -0.017 0.041 0.26 11 -0.28 1 12
MAP3K1 -0.014 0.096 0.22 3 -0.33 25 28
MAP3K7 0.023 0.012 -10000 0 -10000 0 0
RB1 0.012 0.086 0.22 64 -0.26 12 76
CFLAR 0.028 0.003 -10000 0 -10000 0 0
HGF/MET -0.003 0.13 -10000 0 -0.3 90 90
ARHGDIB -0.007 0.045 0.26 6 -0.32 2 8
FADD 0.021 0.017 -10000 0 -10000 0 0
actin filament polymerization 0.006 0.049 0.25 4 -0.22 13 17
NFKB1 -0.021 0.14 -10000 0 -0.67 18 18
MAPK8 -0.063 0.18 0.23 1 -0.48 73 74
DFFA -0.008 0.037 0.21 6 -0.23 1 7
DNA fragmentation during apoptosis -0.006 0.041 0.23 8 -0.23 1 9
FAS/FADD/MET 0.039 0.044 -10000 0 -0.28 6 6
CFLAR/RIP1 0.041 0.008 -10000 0 -10000 0 0
FAIM3 0.017 0.072 -10000 0 -0.44 13 13
FAF1 0.021 0.019 -10000 0 -10000 0 0
PARP1 -0.008 0.037 0.21 6 -0.23 1 7
DFFB -0.007 0.038 0.22 6 -0.23 1 7
CHUK -0.026 0.13 -10000 0 -0.6 20 20
FASLG -0.009 0.12 -10000 0 -0.44 40 40
FAS/FADD 0.027 0.046 -10000 0 -0.32 7 7
HGF 0.001 0.11 -10000 0 -0.44 31 31
LMNA -0.006 0.045 0.2 14 -0.23 2 16
CASP6 -0.007 0.036 0.21 6 -0.23 1 7
CASP10 0.02 0.026 -10000 0 -0.44 1 1
CASP3 -0.001 0.033 0.27 6 -0.23 2 8
PTPN13 -0.032 0.16 -10000 0 -0.44 71 71
CASP8 -0.015 0.056 0.34 13 -0.33 1 14
IL6 -0.12 0.4 -10000 0 -1.1 72 72
MET 0.025 0.021 -10000 0 -0.44 1 1
ICAD/CAD -0.009 0.035 0.25 2 -0.22 1 3
FASLG/FAS/FADD/FAF1/Caspase 10 -0.018 0.12 -10000 0 -0.34 46 46
activation of caspase activity by cytochrome c -0.017 0.041 0.26 11 -0.28 1 12
PAK2 -0.008 0.042 0.21 8 -0.32 2 10
BCL2 0.015 0.05 -10000 0 -0.44 6 6
Canonical Wnt signaling pathway

Figure S57.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S57.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.031 0.025 0.2 3 -10000 0 3
AES 0.029 0.029 0.17 3 -0.44 1 4
FBXW11 0.026 0.004 -10000 0 -10000 0 0
mol:GTP 0 0.001 -10000 0 -10000 0 0
LRP6/FZD1 0.034 0.032 -10000 0 -0.32 4 4
SMAD4 0.019 0.012 -10000 0 -10000 0 0
DKK2 -0.022 0.15 -10000 0 -0.44 62 62
TLE1 0.027 0.045 0.17 3 -0.45 4 7
MACF1 0.026 0.004 -10000 0 -10000 0 0
CTNNB1 0.032 0.099 0.3 12 -0.49 5 17
WIF1 -0.032 0.17 -10000 0 -0.44 78 78
beta catenin/RanBP3 0.037 0.14 0.41 53 -0.49 3 56
KREMEN2 0.022 0.072 -10000 0 -0.44 12 12
DKK1 -0.023 0.16 -10000 0 -0.44 69 69
beta catenin/beta TrCP1 0.043 0.096 0.3 12 -0.44 5 17
FZD1 0.024 0.029 -10000 0 -0.44 2 2
AXIN2 -0.1 0.42 0.57 14 -1.4 52 66
AXIN1 0.026 0.02 -10000 0 -0.44 1 1
RAN 0.027 0.003 -10000 0 -10000 0 0
Axin1/APC/GSK3/beta catenin 0.025 0.093 -10000 0 -0.72 6 6
beta catenin/TCF/CtBP/CBP/TLE1/AES/SMAD4 -0.026 0.16 0.31 3 -0.49 27 30
Axin1/APC/GSK3 0.032 0.083 0.22 4 -0.39 8 12
Axin1/APC/GSK3/beta catenin/Macf1 0.012 0.094 0.28 2 -0.49 7 9
HNF1A 0.026 0.047 0.18 3 -0.41 5 8
CTBP1 0.029 0.03 0.18 3 -0.44 1 4
MYC 0.079 0.28 0.59 98 -1.5 5 103
RANBP3 0.026 0.02 -10000 0 -0.44 1 1
DKK2/LRP6/Kremen 2 0.013 0.12 -10000 0 -0.28 74 74
NKD1 -0.032 0.17 -10000 0 -0.44 80 80
TCF4 0.021 0.045 0.2 4 -0.45 3 7
TCF3 0.03 0.03 0.18 3 -0.44 1 4
WNT1/LRP6/FZD1/Axin1 0.06 0.04 -10000 0 -0.26 6 6
Ran/GTP 0.02 0.003 -10000 0 -10000 0 0
CtBP/CBP/TCF/TLE1/AES 0.009 0.16 0.44 48 -0.48 11 59
LEF1 0.017 0.073 0.18 3 -0.44 12 15
DVL1 0.017 0.086 0.18 2 -0.42 12 14
CSNK2A1 0.021 0.011 -10000 0 -10000 0 0
beta catenin/TCF/CtBP/CBP/TLE1/AES 0.009 0.12 0.3 3 -0.5 14 17
DKK1/LRP6/Kremen 2 0.013 0.12 -10000 0 -0.28 81 81
LRP6 0.024 0.029 -10000 0 -0.45 2 2
CSNK1A1 0.029 0.038 0.19 3 -0.45 2 5
NLK 0.022 0.015 -10000 0 -10000 0 0
CCND1 -0.012 0.096 0.55 1 -1.3 1 2
WNT1 0.018 0.03 -10000 0 -0.44 1 1
GSK3A 0.026 0.004 -10000 0 -10000 0 0
GSK3B 0.025 0.028 -10000 0 -0.45 2 2
FRAT1 0.025 0.021 -10000 0 -0.44 1 1
PPP2R5D 0.057 0.095 0.27 72 -0.26 5 77
APC -0.011 0.078 0.22 32 -0.26 18 50
WNT1/LRP6/FZD1 0.038 0.082 0.2 71 -0.45 4 75
CREBBP 0.03 0.022 0.18 3 -10000 0 3
IL6-mediated signaling events

Figure S58.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S58.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.044 0.22 0.47 1 -0.69 16 17
CRP -0.021 0.2 0.46 1 -0.73 16 17
cell cycle arrest -0.026 0.22 -10000 0 -0.73 26 26
TIMP1 -0.001 0.18 -10000 0 -0.61 18 18
IL6ST 0.013 0.071 -10000 0 -0.45 12 12
Rac1/GDP -0.024 0.15 -10000 0 -0.42 44 44
AP1 0.036 0.14 -10000 0 -0.56 14 14
GAB2 0.025 0.028 -10000 0 -0.44 2 2
TNFSF11 -0.033 0.33 0.46 1 -0.97 52 53
HSP90B1 0.015 0.14 -10000 0 -1.1 8 8
GAB1 0.026 0.005 -10000 0 -10000 0 0
MAPK14 -0.021 0.13 -10000 0 -0.52 21 21
AKT1 0.018 0.081 -10000 0 -0.53 8 8
FOXO1 0.046 0.1 -10000 0 -0.57 6 6
MAP2K6 -0.029 0.13 -10000 0 -0.38 46 46
mol:GTP 0 0.002 -10000 0 -10000 0 0
MAP2K4 -0.032 0.15 0.39 2 -0.44 44 46
MITF -0.031 0.14 0.22 1 -0.4 45 46
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
TYK2 0.025 0.02 -10000 0 -0.44 1 1
A2M 0.005 0.15 -10000 0 -1.1 9 9
CEBPB 0.014 0.027 -10000 0 -0.44 1 1
GRB2/SOS1/GAB family/SHP2 0.02 0.11 -10000 0 -0.54 11 11
STAT3 -0.038 0.23 -10000 0 -0.8 25 25
STAT1 0.016 0.069 -10000 0 -1.1 2 2
CEBPD -0.006 0.21 -10000 0 -0.71 20 20
PIK3CA 0.026 0.028 -10000 0 -0.44 2 2
PI3K 0.036 0.031 -10000 0 -0.32 4 4
JUN 0.023 0.04 -10000 0 -0.44 4 4
PIAS3/MITF -0.012 0.14 0.21 1 -0.4 42 43
MAPK11 -0.023 0.14 -10000 0 -0.56 19 19
STAT3 (dimer)/FOXO1 0.018 0.2 0.34 12 -0.58 22 34
GRB2/SOS1/GAB family 0.042 0.14 -10000 0 -0.46 23 23
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/HCK -0.019 0.13 -10000 0 -0.34 57 57
GRB2 0.026 0.004 -10000 0 -10000 0 0
JAK2 0.014 0.076 -10000 0 -0.44 15 15
LBP 0.005 0.32 0.38 7 -0.83 58 65
PIK3R1 0.025 0.028 -10000 0 -0.44 2 2
JAK1 0.023 0.025 -10000 0 -0.45 1 1
MYC 0.001 0.22 0.46 1 -0.72 24 25
FGG -0.026 0.2 -10000 0 -0.75 17 17
macrophage differentiation -0.026 0.22 -10000 0 -0.73 26 26
IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 0.019 0.14 -10000 0 -0.29 78 78
JUNB -0.024 0.2 -10000 0 -0.73 20 20
FOS 0.013 0.082 -10000 0 -0.44 17 17
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 -0.018 0.14 -10000 0 -0.42 39 39
STAT1/PIAS1 0.003 0.14 -10000 0 -0.42 32 32
GRB2/SOS1/GAB family/SHP2/PI3K 0.023 0.084 -10000 0 -0.48 11 11
STAT3 (dimer) -0.03 0.23 -10000 0 -0.77 26 26
PRKCD -0.022 0.18 0.3 29 -0.5 38 67
IL6R 0.012 0.075 -10000 0 -0.45 14 14
SOCS3 -0.02 0.15 0.38 1 -0.78 11 12
gp130 (dimer)/JAK1/JAK1/LMO4 0.039 0.066 -10000 0 -0.3 13 13
Rac1/GTP -0.025 0.15 -10000 0 -0.44 44 44
HCK 0.006 0.071 -10000 0 -0.44 13 13
MAPKKK cascade 0.028 0.12 -10000 0 -0.6 14 14
bone resorption -0.026 0.31 0.45 1 -0.9 52 53
IRF1 -0.023 0.19 -10000 0 -0.7 18 18
mol:GDP -0.032 0.14 -10000 0 -0.41 48 48
SOS1 0.027 0.002 -10000 0 -10000 0 0
VAV1 -0.034 0.14 -10000 0 -0.42 48 48
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 -0.022 0.16 -10000 0 -0.53 32 32
PTPN11 0.005 0.12 -10000 0 -0.89 9 9
IL6/IL6RA -0.008 0.13 -10000 0 -0.34 65 65
gp130 (dimer)/TYK2/TYK2/LMO4 0.042 0.058 -10000 0 -0.28 14 14
gp130 (dimer)/JAK2/JAK2/LMO4 0.035 0.079 -10000 0 -0.3 26 26
IL6 -0.02 0.14 -10000 0 -0.45 55 55
PIAS3 0.026 0.02 -10000 0 -0.44 1 1
PTPRE 0.021 0.023 -10000 0 -0.43 1 1
PIAS1 0.025 0.006 -10000 0 -10000 0 0
RAC1 0.024 0.008 -10000 0 -10000 0 0
IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 -0.018 0.11 -10000 0 -0.3 67 67
LMO4 0.022 0.03 -10000 0 -0.44 1 1
STAT3 (dimer)/PIAS3 -0.019 0.22 -10000 0 -0.74 27 27
MCL1 0.018 0.078 -10000 0 -0.62 4 4
a4b1 and a4b7 Integrin signaling

Figure S59.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S59.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ITGB1 0.027 0.002 -9999 0 -10000 0 0
ITGB7 0.013 0.084 -9999 0 -0.44 18 18
ITGA4 0.006 0.097 -9999 0 -0.44 25 25
alpha4/beta7 Integrin 0.014 0.1 -9999 0 -0.35 38 38
alpha4/beta1 Integrin 0.024 0.074 -9999 0 -0.32 25 25
Ras signaling in the CD4+ TCR pathway

Figure S60.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S60.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ERK1-2/ELK1 -0.004 0.18 0.28 2 -0.56 37 39
MAP3K8 0.025 0.021 -10000 0 -0.44 1 1
FOS -0.013 0.16 0.29 2 -0.57 34 36
PRKCA 0.023 0.023 -10000 0 -0.44 1 1
PTPN7 0.011 0.096 -10000 0 -0.43 23 23
HRAS 0.026 0.021 -10000 0 -0.44 1 1
PRKCB -0.001 0.11 -10000 0 -0.44 34 34
NRAS 0.018 0.059 -10000 0 -0.44 9 9
RAS family/GTP 0.039 0.055 -10000 0 -0.3 12 12
MAPK3 -0.001 0.14 -10000 0 -0.58 26 26
MAP2K1 -0.01 0.11 -10000 0 -0.4 35 35
ELK1 0.024 0.023 -10000 0 -0.44 1 1
BRAF -0.007 0.094 -10000 0 -0.38 33 33
mol:GTP 0 0.001 -10000 0 -0.004 25 25
MAPK1 -0.018 0.17 -10000 0 -0.55 44 44
RAF1 -0.009 0.1 -10000 0 -0.39 35 35
KRAS 0.022 0.044 -10000 0 -0.44 5 5
Lissencephaly gene (LIS1) in neuronal migration and development

Figure S61.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S61.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
DYNC1H1 0.025 0.007 -10000 0 -10000 0 0
VLDLR -0.001 0.11 -10000 0 -0.44 34 34
LRPAP1 0.025 0.02 -10000 0 -0.44 1 1
NUDC 0.025 0.007 -10000 0 -10000 0 0
RELN/LRP8 0.021 0.099 -10000 0 -0.27 56 56
CaM/Ca2+ 0.018 0.005 -10000 0 -10000 0 0
KATNA1 0.025 0.02 -10000 0 -0.44 1 1
GO:0030286 0 0 -10000 0 -10000 0 0
ABL1 -0.035 0.083 0.18 21 -0.25 56 77
IQGAP1/CaM 0.034 0.024 -10000 0 -0.32 2 2
DAB1 -0.009 0.12 -10000 0 -0.44 41 41
IQGAP1 0.024 0.029 -10000 0 -0.44 2 2
PLA2G7 0.006 0.097 -10000 0 -0.44 25 25
CALM1 0.025 0.007 -10000 0 -10000 0 0
DYNLT1 0.026 0.004 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
LRPAP1/LRP8 0.035 0.031 -10000 0 -0.32 4 4
UniProt:Q4QZ09 0 0 -10000 0 -10000 0 0
CLIP1 0.025 0.028 -10000 0 -0.44 2 2
CDK5R1 0.026 0.007 -10000 0 -10000 0 0
LIS1/Poliovirus Protein 3A -0.007 0.004 -10000 0 -10000 0 0
CDK5R2 0.007 0.095 -10000 0 -0.44 22 22
mol:PP1 0 0 -10000 0 -10000 0 0
RELN/VLDLR/DAB1 -0.014 0.15 -10000 0 -0.31 108 108
YWHAE 0.022 0.01 -10000 0 -10000 0 0
NDEL1/14-3-3 E -0.011 0.1 0.31 16 -0.31 19 35
MAP1B 0.001 0.034 -10000 0 -0.29 7 7
RAC1 0.007 0.009 -10000 0 -0.15 1 1
p35/CDK5 -0.039 0.067 0.17 6 -0.23 51 57
RELN -0.014 0.14 -10000 0 -0.44 52 52
PAFAH/LIS1 0.01 0.055 0.21 1 -0.26 21 22
LIS1/CLIP170 0.019 0.018 -10000 0 -0.27 1 1
LIS1/NDEL1/Katanin 60/Dynein Light chain/Dynein heavy chain -0.016 0.078 -10000 0 -0.32 8 8
RELN/VLDLR/DAB1/LIS1/PAFAH1B2/PAFAH1B3 -0.03 0.13 -10000 0 -0.28 101 101
GO:0005869 0 0 -10000 0 -10000 0 0
NDEL1 -0.032 0.1 0.28 16 -0.32 23 39
LIS1/IQGAP1 0.018 0.018 -10000 0 -0.27 1 1
RHOA 0.007 0.029 -10000 0 -0.68 1 1
PAFAH1B1 -0.008 0.005 -10000 0 -10000 0 0
PAFAH1B3 0.025 0.029 -10000 0 -0.44 2 2
PAFAH1B2 0.023 0.04 -10000 0 -0.44 4 4
MAP1B/LIS1/Dynein heavy chain 0.01 0.038 -10000 0 -0.18 11 11
NDEL1/Katanin 60/Dynein heavy chain -0.013 0.11 0.31 12 -0.33 17 29
LRP8 0.023 0.035 -10000 0 -0.44 3 3
NDEL1/Katanin 60 -0.023 0.1 0.31 13 -0.31 22 35
P39/CDK5 -0.045 0.089 0.2 9 -0.25 69 78
LIS1/NudC/Dynein intermediate chain/microtubule organizing center 0.019 0.013 -10000 0 -10000 0 0
CDK5 -0.039 0.07 0.17 7 -0.24 55 62
PPP2R5D 0.026 0.004 -10000 0 -10000 0 0
LIS1/CLIP170/Dynein Complex/Dynactin Complex 0.016 0.015 -10000 0 -0.23 1 1
CSNK2A1 0.021 0.011 -10000 0 -10000 0 0
RELN/VLDLR/DAB1/LIS1 -0.009 0.13 0.22 10 -0.27 96 106
RELN/VLDLR 0.017 0.12 -10000 0 -0.28 79 79
CDC42 0.005 0.044 -10000 0 -0.5 4 4
Class I PI3K signaling events

Figure S62.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S62.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ARF5/GTP -0.022 0.067 0.22 2 -0.35 6 8
DAPP1 -0.023 0.18 0.24 14 -0.42 60 74
Src family/SYK family/BLNK-LAT/BTK-ITK -0.063 0.23 0.28 1 -0.55 68 69
mol:DAG 0.002 0.11 0.17 86 -0.26 34 120
HRAS 0.024 0.024 -10000 0 -0.45 1 1
RAP1A 0.024 0.024 -10000 0 -0.48 1 1
ARF5/GDP 0.026 0.12 0.21 2 -0.43 23 25
PLCG2 0.015 0.076 -10000 0 -0.44 15 15
PLCG1 0.015 0.023 -10000 0 -0.44 1 1
ARF5 0.026 0.005 -10000 0 -10000 0 0
mol:GTP -0.027 0.055 0.16 11 -0.26 20 31
ARF1/GTP -0.012 0.062 0.24 3 -0.25 19 22
RHOA 0.025 0.02 -10000 0 -0.44 1 1
YES1 0.019 0.035 -10000 0 -0.44 3 3
RAP1A/GTP -0.027 0.053 0.16 10 -0.25 20 30
ADAP1 -0.028 0.054 0.28 1 -0.27 17 18
ARAP3 -0.027 0.054 0.15 11 -0.25 20 31
INPPL1 0.025 0.02 -10000 0 -0.44 1 1
PREX1 0.012 0.041 -10000 0 -0.44 4 4
ARHGEF6 0.018 0.066 -10000 0 -0.44 11 11
ARHGEF7 0.02 0.011 -10000 0 -10000 0 0
ARF1 0.026 0.005 -10000 0 -10000 0 0
NRAS 0.018 0.061 -10000 0 -0.45 9 9
FYN 0.023 0.04 -10000 0 -0.44 4 4
ARF6 0.024 0.021 -10000 0 -0.44 1 1
FGR 0.01 0.088 -10000 0 -0.44 20 20
mol:Ca2+ 0.004 0.06 0.15 20 -0.15 12 32
mol:IP4 0 0 -10000 0 -10000 0 0
TIAM1 0.008 0.1 -10000 0 -0.44 26 26
ZAP70 0.003 0.11 -10000 0 -0.44 31 31
mol:IP3 -0.001 0.076 0.18 19 -0.19 26 45
LYN 0.023 0.009 -10000 0 -10000 0 0
ARF1/GDP 0.027 0.12 0.21 3 -0.43 23 26
RhoA/GDP 0.029 0.092 0.23 10 -0.34 17 27
PDK1/Src/Hsp90 0.03 0.03 -10000 0 -0.27 1 1
BLNK 0.01 0.083 -10000 0 -0.44 18 18
actin cytoskeleton reorganization 0.02 0.11 0.22 32 -0.4 18 50
SRC 0.015 0.023 -10000 0 -0.44 1 1
PLEKHA2 -0.023 0.055 -10000 0 -0.28 23 23
RAC1 0.024 0.008 -10000 0 -10000 0 0
PTEN 0.027 0.01 -10000 0 -10000 0 0
HSP90AA1 0.024 0.021 -10000 0 -0.44 1 1
ARF6/GTP -0.028 0.058 0.29 1 -0.31 11 12
RhoA/GTP -0.028 0.057 0.16 11 -0.31 11 22
Src family/SYK family/BLNK-LAT -0.041 0.16 -10000 0 -0.49 43 43
BLK -0.021 0.14 -10000 0 -0.44 54 54
PDPK1 0.026 0.004 -10000 0 -10000 0 0
CYTH1 -0.029 0.052 0.28 1 -0.26 17 18
HCK 0.006 0.071 -10000 0 -0.44 13 13
CYTH3 -0.028 0.053 0.28 1 -0.28 13 14
CYTH2 -0.029 0.051 0.28 1 -0.26 16 17
KRAS 0.021 0.047 -10000 0 -0.46 5 5
GO:0030676 0 0 -10000 0 -10000 0 0
FOXO3 0.013 0.065 -10000 0 -0.46 7 7
SGK1 0 0.073 -10000 0 -0.43 11 11
INPP5D 0.006 0.095 -10000 0 -0.44 24 24
mol:GDP 0.016 0.12 0.18 8 -0.43 25 33
SOS1 0.027 0.002 -10000 0 -10000 0 0
SYK 0.026 0.004 -10000 0 -10000 0 0
ARF6/GDP 0.004 0.089 0.22 13 -0.33 17 30
mol:PI-3-4-5-P3 -0.027 0.054 0.28 1 -0.26 20 21
ARAP3/RAP1A/GTP -0.027 0.054 0.16 10 -0.26 20 30
VAV1 -0.001 0.11 -10000 0 -0.44 33 33
mol:PI-3-4-P2 -0.025 0.065 -10000 0 -0.33 24 24
RAS family/GTP/PI3K Class I 0.03 0.067 0.2 8 -0.26 20 28
PLEKHA1 -0.026 0.058 -10000 0 -0.28 27 27
Rac1/GDP 0.021 0.12 0.24 1 -0.43 23 24
LAT 0.019 0.063 -10000 0 -0.44 10 10
Rac1/GTP -0.015 0.11 -10000 0 -0.47 24 24
ITK -0.04 0.07 0.28 1 -0.26 42 43
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma -0.011 0.13 0.19 79 -0.38 34 113
LCK 0.014 0.085 -10000 0 -0.44 18 18
BTK -0.039 0.068 0.28 1 -0.25 36 37
ErbB2/ErbB3 signaling events

Figure S63.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S63.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
USP8 -0.011 0.023 -10000 0 -0.27 4 4
RAS family/GTP 0.005 0.097 -10000 0 -0.3 13 13
NFATC4 -0.029 0.067 0.25 3 -0.28 6 9
ERBB2IP 0.011 0.082 -10000 0 -0.44 18 18
HSP90 (dimer) 0.024 0.021 -10000 0 -0.44 1 1
mammary gland morphogenesis -0.003 0.082 0.22 8 -0.25 38 46
JUN -0.007 0.084 0.21 3 -0.33 17 20
HRAS 0.025 0.021 -10000 0 -0.45 1 1
DOCK7 -0.034 0.073 0.18 9 -0.24 38 47
ErbB2/ErbB3/neuregulin 1 beta/SHC 0.024 0.088 0.25 14 -0.25 38 52
AKT1 -0.006 0.015 -10000 0 -0.32 1 1
BAD -0.01 0.021 -10000 0 -0.51 1 1
MAPK10 -0.021 0.066 0.2 6 -0.2 24 30
mol:GTP 0 0.001 -10000 0 -10000 0 0
ErbB2/ErbB3/neuregulin 1 beta 0 0.09 0.23 8 -0.26 38 46
RAF1 -0.016 0.09 0.28 3 -0.32 12 15
ErbB2/ErbB3/neuregulin 2 0.033 0.056 0.23 29 -0.27 2 31
STAT3 0.012 0.085 -10000 0 -0.86 5 5
cell migration -0.015 0.067 0.2 12 -0.22 11 23
mol:PI-3-4-5-P3 -0.001 0.001 -10000 0 -10000 0 0
cell proliferation -0.048 0.2 0.35 2 -0.6 49 51
FOS -0.033 0.15 0.31 2 -0.39 66 68
NRAS 0.018 0.059 -10000 0 -0.44 9 9
mol:Ca2+ -0.003 0.082 0.22 8 -0.25 38 46
MAPK3 -0.03 0.16 0.34 2 -0.51 34 36
MAPK1 -0.047 0.18 0.34 2 -0.56 46 48
JAK2 -0.037 0.074 0.2 4 -0.25 43 47
NF2 0.003 0.053 -10000 0 -0.61 4 4
ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 -0.001 0.071 0.2 3 -0.24 37 40
NRG1 -0.009 0.12 -10000 0 -0.45 39 39
GRB2/SOS1 0.039 0.007 -10000 0 -10000 0 0
MAPK8 -0.02 0.094 0.23 2 -0.26 36 38
MAPK9 -0.015 0.056 0.2 6 -0.21 3 9
ERBB2 -0.01 0.069 0.35 18 -0.34 1 19
ERBB3 0.025 0.02 -10000 0 -0.45 1 1
SHC1 0.026 0.004 -10000 0 -10000 0 0
RAC1 0.024 0.008 -10000 0 -10000 0 0
apoptosis 0.006 0.028 0.65 1 -10000 0 1
STAT3 (dimer) 0.012 0.083 -10000 0 -0.84 5 5
RNF41 -0.014 0.021 -10000 0 -0.24 4 4
FRAP1 -0.005 0.012 -10000 0 -0.27 1 1
RAC1-CDC42/GTP -0.035 0.047 -10000 0 -0.2 35 35
ErbB2/ErbB2/HSP90 (dimer) -0.012 0.047 0.25 15 -0.28 1 16
CHRNA1 -0.031 0.17 0.32 2 -0.57 37 39
myelination -0.025 0.071 0.27 5 -0.4 2 7
PPP3CB -0.032 0.069 0.17 9 -0.23 36 45
KRAS 0.022 0.044 -10000 0 -0.44 5 5
RAC1-CDC42/GDP 0.007 0.081 -10000 0 -0.22 33 33
NRG2 0.019 0.027 -10000 0 -10000 0 0
mol:GDP -0.001 0.071 0.2 3 -0.24 37 40
SOS1 0.027 0.002 -10000 0 -10000 0 0
MAP2K2 -0.024 0.091 0.26 3 -0.34 14 17
SRC 0.015 0.023 -10000 0 -0.44 1 1
mol:cAMP -0.001 0.001 -10000 0 -10000 0 0
PTPN11 -0.034 0.074 0.18 8 -0.24 40 48
MAP2K1 -0.054 0.2 0.35 1 -0.59 48 49
heart morphogenesis -0.003 0.082 0.22 8 -0.25 38 46
RAS family/GDP 0.009 0.099 -10000 0 -0.3 12 12
GRB2 0.026 0.004 -10000 0 -10000 0 0
PRKACA 0.007 0.056 -10000 0 -0.65 4 4
CHRNE -0.001 0.035 0.07 1 -0.18 17 18
HSP90AA1 0.024 0.021 -10000 0 -0.44 1 1
activation of caspase activity 0.006 0.015 0.32 1 -10000 0 1
nervous system development -0.003 0.082 0.22 8 -0.25 38 46
CDC42 0.022 0.04 -10000 0 -0.44 4 4
IL27-mediated signaling events

Figure S64.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S64.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 -0.014 0.14 -10000 0 -0.43 54 54
CD4-positive alpha-beta T cell lineage commitment 0 0 -10000 0 -10000 0 0
cytokine production during immune response 0.021 0.12 0.52 14 -10000 0 14
IL27/IL27R/JAK1 0.023 0.15 -10000 0 -0.74 8 8
TBX21 -0.052 0.16 -10000 0 -0.53 36 36
IL12B 0.018 0.022 -10000 0 -10000 0 0
IL12A -0.021 0.079 -10000 0 -0.32 37 37
IL6ST 0.012 0.071 -10000 0 -0.46 12 12
IL27RA/JAK1 0.008 0.1 -10000 0 -1.2 4 4
IL27 0.017 0.027 -10000 0 -10000 0 0
TYK2 0.021 0.027 -10000 0 -0.45 1 1
T-helper cell lineage commitment -0.11 0.4 0.94 2 -1.3 49 51
T-helper 2 cell differentiation 0.021 0.12 0.52 14 -10000 0 14
T cell proliferation during immune response 0.021 0.12 0.52 14 -10000 0 14
MAPKKK cascade -0.021 0.12 -10000 0 -0.52 14 14
STAT3 0.026 0.004 -10000 0 -10000 0 0
STAT2 0.027 0.004 -10000 0 -10000 0 0
STAT1 0.025 0.029 -10000 0 -0.44 2 2
IL12RB1 0 0.11 -10000 0 -0.44 31 31
positive regulation of tyrosine phosphorylation of STAT protein 0 0 -10000 0 -10000 0 0
IL12RB2 -0.049 0.16 0.36 1 -0.5 40 41
IL27/IL27R/JAK2/TYK2 -0.021 0.12 -10000 0 -0.53 14 14
positive regulation of T cell mediated cytotoxicity -0.021 0.12 -10000 0 -0.52 14 14
STAT1 (dimer) 0.014 0.21 0.48 7 -0.67 24 31
JAK2 0.011 0.078 -10000 0 -0.44 15 15
JAK1 0.025 0.021 -10000 0 -0.44 1 1
STAT2 (dimer) -0.009 0.13 -10000 0 -0.5 14 14
T cell proliferation -0.06 0.15 -10000 0 -0.47 37 37
IL12/IL12R/TYK2/JAK2 -0.034 0.2 -10000 0 -0.85 20 20
IL17A -0.11 0.4 0.95 2 -1.3 49 51
mast cell activation 0.021 0.12 0.52 14 -10000 0 14
IFNG -0.005 0.04 -10000 0 -0.12 43 43
T cell differentiation -0.002 0.007 -10000 0 -0.023 38 38
STAT3 (dimer) -0.009 0.13 -10000 0 -0.5 14 14
STAT5A (dimer) -0.009 0.13 -10000 0 -0.5 14 14
STAT4 (dimer) -0.019 0.15 -10000 0 -0.46 33 33
STAT4 0.002 0.11 -10000 0 -0.44 31 31
T cell activation -0.004 0.009 0.12 3 -10000 0 3
IL27R/JAK2/TYK2 0.014 0.13 -10000 0 -0.8 7 7
GATA3 -0.036 0.21 0.53 2 -1.3 16 18
IL18 -0.008 0.03 -10000 0 -0.32 5 5
positive regulation of mast cell cytokine production -0.008 0.12 -10000 0 -0.49 14 14
IL27/EBI3 0.014 0.087 -10000 0 -0.33 31 31
IL27RA -0.006 0.11 -10000 0 -1.2 4 4
IL6 -0.046 0.19 -10000 0 -0.47 89 89
STAT5A 0.026 0.004 -10000 0 -10000 0 0
monocyte differentiation 0 0.002 -10000 0 -10000 0 0
IL2 -0.01 0.043 0.47 4 -10000 0 4
IL1B -0.031 0.08 -10000 0 -0.32 40 40
EBI3 -0.003 0.11 -10000 0 -0.45 31 31
TNF -0.016 0.057 -10000 0 -0.32 19 19
Signaling events mediated by PTP1B

Figure S65.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S65.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB 0.02 0.056 -10000 0 -0.44 8 8
Jak2/Leptin Receptor 0.005 0.13 0.27 1 -0.37 36 37
PTP1B/AKT1 0.027 0.087 0.22 4 -0.29 13 17
FYN 0.023 0.04 -10000 0 -0.44 4 4
p210 bcr-abl/PTP1B 0.022 0.093 0.2 17 -0.31 12 29
EGFR 0.015 0.048 -10000 0 -0.45 5 5
EGF/EGFR 0.012 0.13 -10000 0 -0.27 50 50
CSF1 0.024 0.035 -10000 0 -0.44 3 3
AKT1 0.025 0.021 -10000 0 -0.45 1 1
INSR 0.026 0.02 -10000 0 -0.44 1 1
PTP1B/N-cadherin 0.009 0.11 0.2 7 -0.31 33 40
Insulin Receptor/Insulin 0.033 0.081 0.23 1 -0.31 8 9
HCK 0.006 0.071 -10000 0 -0.44 13 13
CRK 0.022 0.011 -10000 0 -10000 0 0
TYK2 0.018 0.091 0.3 6 -0.3 13 19
EGF -0.027 0.18 -10000 0 -0.45 80 80
YES1 0.019 0.035 -10000 0 -0.44 3 3
CAV1 0.032 0.12 0.24 33 -0.34 14 47
TXN 0.026 0.004 -10000 0 -10000 0 0
PTP1B/IRS1/GRB2 0.037 0.1 0.23 3 -0.29 16 19
cell migration -0.022 0.093 0.31 12 -0.2 17 29
STAT3 0.026 0.004 -10000 0 -10000 0 0
PRLR -0.014 0.13 -10000 0 -0.44 49 49
ITGA2B 0.007 0.098 -10000 0 -0.45 24 24
CSF1R 0.009 0.094 -10000 0 -0.44 23 23
Prolactin Receptor/Prolactin 0.005 0.1 -10000 0 -0.33 49 49
FGR 0.01 0.088 -10000 0 -0.44 20 20
PTP1B/p130 Cas 0.029 0.093 0.21 5 -0.3 13 18
Crk/p130 Cas 0.031 0.091 0.22 2 -0.3 12 14
DOK1 0.018 0.092 0.22 5 -0.3 17 22
JAK2 -0.002 0.13 0.22 3 -0.36 39 42
Jak2/Leptin Receptor/Leptin 0.023 0.11 -10000 0 -0.36 14 14
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
PTPN1 0.022 0.093 0.2 17 -0.31 12 29
LYN 0.023 0.009 -10000 0 -10000 0 0
CDH2 -0.009 0.12 -10000 0 -0.44 40 40
SRC 0.024 0.1 -10000 0 -0.49 15 15
ITGB3 0.017 0.066 -10000 0 -0.45 11 11
CAT1/PTP1B 0.017 0.18 0.26 60 -0.46 35 95
CAPN1 0.025 0.021 -10000 0 -0.45 1 1
CSK 0.025 0.021 -10000 0 -0.44 1 1
PI3K 0.036 0.085 -10000 0 -0.32 9 9
mol:H2O2 0 0.004 -10000 0 -10000 0 0
STAT3 (dimer) 0.022 0.1 -10000 0 -0.36 13 13
negative regulation of transcription -0.002 0.13 0.22 3 -0.36 39 42
FCGR2A 0.01 0.09 -10000 0 -0.44 21 21
FER 0.024 0.03 -10000 0 -0.45 2 2
alphaIIb/beta3 Integrin 0.019 0.089 -10000 0 -0.32 35 35
BLK -0.021 0.14 -10000 0 -0.44 54 54
Insulin Receptor/Insulin/Shc 0.044 0.02 -10000 0 -0.28 1 1
RHOA 0.025 0.021 -10000 0 -0.45 1 1
LEPR 0.019 0.056 -10000 0 -0.44 8 8
BCAR1 0.025 0.029 -10000 0 -0.44 2 2
p210 bcr-abl/Grb2 0.026 0.004 -10000 0 -10000 0 0
mol:NADPH 0 0.003 -10000 0 -10000 0 0
TRPV6 -0.049 0.2 0.24 14 -0.49 60 74
PRL 0.008 0.028 -10000 0 -10000 0 0
SOCS3 -0.003 0.17 -10000 0 -1.1 13 13
SPRY2 0.019 0.03 -10000 0 -0.45 2 2
Insulin Receptor/Insulin/IRS1 0.04 0.045 -10000 0 -0.28 10 10
CSF1/CSF1R 0.031 0.11 0.24 4 -0.33 22 26
Ras protein signal transduction -0.012 0.059 0.47 6 -10000 0 6
IRS1 0.019 0.059 -10000 0 -0.44 9 9
INS 0.01 0.017 -10000 0 -10000 0 0
LEP 0.017 0.034 -10000 0 -0.44 1 1
STAT5B 0.017 0.097 0.19 14 -0.28 21 35
STAT5A 0.017 0.097 0.19 14 -0.28 21 35
GRB2 0.026 0.004 -10000 0 -10000 0 0
PDGFB-D/PDGFRB 0.029 0.1 0.21 8 -0.33 18 26
CSN2 -0.018 0.059 -10000 0 -10000 0 0
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
LAT 0.01 0.13 -10000 0 -0.48 31 31
YBX1 0.033 0.026 -10000 0 -0.56 1 1
LCK 0.014 0.085 -10000 0 -0.44 18 18
SHC1 0.026 0.004 -10000 0 -10000 0 0
NOX4 -0.005 0.12 -10000 0 -0.45 39 39
S1P1 pathway

Figure S66.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S66.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR2 homodimer/VEGFA homodimer 0.032 0.033 -10000 0 -0.32 3 3
PDGFRB 0.021 0.057 -10000 0 -0.45 8 8
SPHK1 -0.023 0.14 -10000 0 -0.66 26 26
mol:S1P -0.023 0.13 -10000 0 -0.56 26 26
S1P1/S1P/Gi -0.008 0.14 -10000 0 -0.37 52 52
GNAO1 0.015 0.086 -10000 0 -0.45 17 17
PDGFB-D/PDGFRB/PLCgamma1 0.038 0.15 0.29 19 -0.4 26 45
PLCG1 -0.023 0.11 0.27 4 -0.4 28 32
mol:GTP 0 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB 0.021 0.057 -10000 0 -0.45 8 8
GNAI2 0.023 0.015 -10000 0 -10000 0 0
GNAI3 0.024 0.014 -10000 0 -10000 0 0
GNAI1 0.015 0.064 -10000 0 -0.45 10 10
mol:GDP 0 0 -10000 0 -10000 0 0
EDG1 -0.011 0.022 -10000 0 -0.28 3 3
S1P1/S1P -0.001 0.11 0.21 2 -0.4 25 27
negative regulation of cAMP metabolic process -0.007 0.13 -10000 0 -0.36 52 52
MAPK3 -0.029 0.18 0.24 1 -0.52 54 55
calcium-dependent phospholipase C activity -0.001 0.003 -10000 0 -10000 0 0
Rac1/GDP 0.018 0.006 -10000 0 -10000 0 0
RhoA/GDP 0.019 0.014 -10000 0 -0.32 1 1
KDR 0.021 0.037 -10000 0 -0.45 3 3
PLCB2 0.005 0.11 0.26 11 -0.38 24 35
RAC1 0.024 0.008 -10000 0 -10000 0 0
RhoA/GTP -0.001 0.09 -10000 0 -0.35 25 25
receptor internalization -0.001 0.099 -10000 0 -0.38 25 25
PTGS2 -0.055 0.29 0.44 4 -0.97 47 51
Rac1/GTP -0.002 0.087 -10000 0 -0.34 24 24
RHOA 0.025 0.02 -10000 0 -0.44 1 1
VEGFA 0.023 0.013 -10000 0 -10000 0 0
negative regulation of T cell proliferation -0.007 0.13 -10000 0 -0.36 52 52
GO:0007205 0 0 -10000 0 -10000 0 0
GNAZ 0.014 0.073 -10000 0 -0.45 13 13
MAPK1 -0.026 0.17 -10000 0 -0.52 50 50
S1P1/S1P/PDGFB-D/PDGFRB 0.023 0.12 0.29 12 -0.37 23 35
ABCC1 0.025 0.022 -10000 0 -0.45 1 1
Glypican 2 network

Figure S67.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S67.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MDK 0.021 0.06 -9999 0 -0.44 9 9
GPC2 0.013 0.076 -9999 0 -0.44 15 15
GPC2/Midkine 0.024 0.074 -9999 0 -0.32 24 24
neuron projection morphogenesis 0.023 0.074 -9999 0 -0.32 24 24
FOXM1 transcription factor network

Figure S68.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S68.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC3 0.008 0.29 -10000 0 -1 18 18
PLK1 0.029 0.11 -10000 0 -1.1 4 4
BIRC5 0.024 0.11 -10000 0 -0.82 9 9
HSPA1B 0.005 0.3 -10000 0 -1 20 20
MAP2K1 0.025 0.049 -10000 0 -0.49 2 2
BRCA2 0.032 0.35 0.56 1 -1.1 28 29
FOXM1 0 0.35 -10000 0 -1.3 18 18
XRCC1 0.009 0.3 -10000 0 -1 19 19
FOXM1B/p19 -0.013 0.33 -10000 0 -1.1 23 23
Cyclin D1/CDK4 0.021 0.28 -10000 0 -0.92 18 18
CDC2 0.008 0.31 -10000 0 -1.1 18 18
TGFA 0.007 0.28 -10000 0 -0.89 22 22
SKP2 0.01 0.3 -10000 0 -1.1 18 18
CCNE1 0.025 0.016 -10000 0 -10000 0 0
CKS1B 0.011 0.3 -10000 0 -1 18 18
RB1 0.009 0.21 -10000 0 -0.87 20 20
FOXM1C/SP1 0.011 0.33 -10000 0 -1.2 19 19
AURKB -0.11 0.34 -10000 0 -0.82 99 99
CENPF -0.001 0.33 -10000 0 -1.1 26 26
CDK4 0.021 0.025 -10000 0 -10000 0 0
MYC -0.001 0.26 -10000 0 -0.88 19 19
CHEK2 0.026 0.045 -10000 0 -0.49 1 1
ONECUT1 0.01 0.28 -10000 0 -0.98 18 18
CDKN2A -0.013 0.12 -10000 0 -0.44 37 37
LAMA4 0.007 0.3 -10000 0 -1.1 18 18
FOXM1B/HNF6 0.002 0.32 -10000 0 -1.2 18 18
FOS -0.024 0.36 -10000 0 -1.1 40 40
SP1 0.026 0.021 -10000 0 -0.44 1 1
CDC25B 0.032 0.3 -10000 0 -1 18 18
response to radiation 0.008 0.02 -10000 0 -10000 0 0
CENPB 0.031 0.31 -10000 0 -1 19 19
CENPA 0.006 0.3 -10000 0 -1.1 18 18
NEK2 0.011 0.3 -10000 0 -1 18 18
HIST1H2BA 0.004 0.29 -10000 0 -1 18 18
CCNA2 0.024 0.026 -10000 0 -0.46 1 1
EP300 0.024 0.029 -10000 0 -0.44 2 2
CCNB1/CDK1 -0.001 0.33 -10000 0 -1.2 18 18
CCNB2 0.006 0.3 -10000 0 -1 20 20
CCNB1 0.007 0.31 -10000 0 -1.1 18 18
ETV5 -0.002 0.32 -10000 0 -1.1 24 24
ESR1 -0.024 0.37 -10000 0 -1.1 39 39
CCND1 0.01 0.28 -10000 0 -0.94 18 18
GSK3A 0.025 0.036 -10000 0 -10000 0 0
Cyclin A-E1/CDK1-2 0.046 0.054 -10000 0 -0.54 1 1
CDK2 0.024 0.026 -10000 0 -0.46 1 1
G2/M transition of mitotic cell cycle 0.009 0.024 -10000 0 -10000 0 0
FOXM1B/Cbp/p300 0.017 0.32 -10000 0 -1.1 18 18
GAS1 -0.082 0.46 -10000 0 -1.1 80 80
MMP2 -0.016 0.36 -10000 0 -1.2 34 34
RB1/FOXM1C -0.008 0.28 -10000 0 -0.96 23 23
CREBBP 0.026 0.004 -10000 0 -10000 0 0
S1P4 pathway

Figure S69.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S69.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:S1P 0 0 -10000 0 -10000 0 0
GNAO1 0.018 0.084 -10000 0 -0.44 17 17
CDC42/GTP 0.001 0.096 -10000 0 -0.28 36 36
PLCG1 -0.005 0.08 0.19 18 -0.29 22 40
mol:GTP 0 0 -10000 0 -10000 0 0
GNAI2 0.026 0.004 -10000 0 -10000 0 0
GNAI3 0.026 0.005 -10000 0 -10000 0 0
G12/G13 0.034 0.025 -10000 0 -0.32 2 2
cell migration 0.001 0.094 -10000 0 -0.28 37 37
S1PR5 0.021 0.053 -10000 0 -0.44 7 7
S1PR4 0.01 0.092 -10000 0 -0.44 22 22
MAPK3 -0.016 0.091 0.19 1 -0.29 36 37
MAPK1 -0.01 0.085 -10000 0 -0.29 33 33
S1P/S1P5/Gi -0.002 0.087 -10000 0 -0.25 47 47
GNAI1 0.018 0.063 -10000 0 -0.44 10 10
CDC42/GDP 0.016 0.028 -10000 0 -0.32 4 4
S1P/S1P5/G12 0.029 0.036 -10000 0 -0.27 7 7
RHOA -0.004 0.074 0.19 52 -0.23 19 71
S1P/S1P4/Gi -0.007 0.096 -10000 0 -0.27 51 51
mol:GDP 0 0 -10000 0 -10000 0 0
GNAZ 0.015 0.071 -10000 0 -0.44 13 13
S1P/S1P4/G12/G13 0.036 0.055 -10000 0 -0.25 18 18
GNA12 0.024 0.008 -10000 0 -10000 0 0
GNA13 0.024 0.028 -10000 0 -0.44 2 2
CDC42 0.022 0.04 -10000 0 -0.44 4 4
Paxillin-independent events mediated by a4b1 and a4b7

Figure S70.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S70.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.002 0.083 -10000 0 -0.35 29 29
CRKL 0.026 0.005 -10000 0 -10000 0 0
Rac1/GDP 0.018 0.006 -10000 0 -10000 0 0
DOCK1 0.025 0.02 -10000 0 -0.44 1 1
ITGA4 0.006 0.097 -10000 0 -0.44 25 25
alpha4/beta7 Integrin/MAdCAM1 0.011 0.14 -10000 0 -0.27 101 101
EPO 0.007 0.024 -10000 0 -10000 0 0
alpha4/beta7 Integrin 0.014 0.1 -10000 0 -0.35 38 38
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.022 0.011 -10000 0 -10000 0 0
alpha4/beta1 Integrin 0.024 0.074 -10000 0 -0.32 25 25
EPO/EPOR (dimer) 0.035 0.02 -10000 0 -0.32 1 1
lamellipodium assembly -0.002 0.094 -10000 0 -0.32 36 36
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
PI3K 0.035 0.031 -10000 0 -0.32 4 4
ARF6 0.024 0.021 -10000 0 -0.44 1 1
JAK2 0.002 0.084 -10000 0 -0.31 33 33
PXN 0.027 0.002 -10000 0 -10000 0 0
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
MADCAM1 -0.024 0.16 -10000 0 -0.44 68 68
cell adhesion 0.009 0.14 -10000 0 -0.27 101 101
CRKL/CBL 0.037 0.009 -10000 0 -10000 0 0
ITGB1 0.027 0.002 -10000 0 -10000 0 0
SRC -0.022 0.067 -10000 0 -0.35 20 20
ITGB7 0.013 0.084 -10000 0 -0.44 18 18
RAC1 0.024 0.008 -10000 0 -10000 0 0
alpha4/beta1 Integrin/VCAM1 0.031 0.099 -10000 0 -0.35 32 32
p130Cas/Crk/Dock1 0.042 0.095 -10000 0 -0.34 19 19
VCAM1 0.012 0.084 -10000 0 -0.44 18 18
RHOA 0.025 0.02 -10000 0 -0.44 1 1
alpha4/beta1 Integrin/Paxillin/GIT1 0.053 0.066 -10000 0 -0.25 24 24
BCAR1 -0.023 0.066 0.13 1 -0.34 20 21
EPOR 0.025 0.029 -10000 0 -0.44 2 2
mol:GDP 0 0 -10000 0 -10000 0 0
CBL 0.026 0.004 -10000 0 -10000 0 0
GIT1 0.025 0.02 -10000 0 -0.44 1 1
Rac1/GTP -0.002 0.097 -10000 0 -0.32 36 36
Visual signal transduction: Cones

Figure S71.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S71.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Cone Metarhodopsin II/Cone Transducin 0.026 0.072 -10000 0 -0.24 37 37
RGS9BP 0.009 0.074 -10000 0 -0.44 14 14
mol:GTP 0 0 -10000 0 -10000 0 0
GRK1 -0.009 0.016 -10000 0 -10000 0 0
mol:Na + 0.016 0.07 -10000 0 -0.27 29 29
mol:ADP -0.012 0.027 0.22 6 -10000 0 6
GNAT2 0.016 0.058 -10000 0 -0.44 8 8
RGS9-1/Gbeta5/R9AP 0.028 0.085 -10000 0 -0.28 37 37
mol:GDP 0 0 -10000 0 -10000 0 0
PDE6H/GNAT2/GTP 0.025 0.037 -10000 0 -0.27 8 8
GRK7 0.012 0.024 -10000 0 -10000 0 0
CNGB3 0.002 0.03 -10000 0 -10000 0 0
Cone Metarhodopsin II/X-Arrestin 0.016 0.006 -10000 0 -10000 0 0
mol:Ca2+ -0.009 0.088 0.18 70 -0.25 29 99
Cone PDE6 0.04 0.082 -10000 0 -0.25 37 37
Cone Metarhodopsin II 0.022 0.014 -10000 0 -10000 0 0
Na + (4 Units) 0.028 0.07 0.21 1 -0.25 29 30
GNAT2/GDP 0.032 0.083 -10000 0 -0.24 44 44
GNB5 0.024 0.029 -10000 0 -0.44 2 2
mol:GMP (4 units) -0.019 0.035 0.18 6 -0.25 8 14
Cone Transducin 0.028 0.077 -10000 0 -0.25 37 37
SLC24A2 0.009 0.038 -10000 0 -0.44 2 2
GNB3/GNGT2 0.019 0.084 -10000 0 -0.33 30 30
GNB3 0.012 0.084 -10000 0 -0.44 18 18
GNAT2/GTP 0.015 0.04 -10000 0 -0.32 8 8
CNGA3 -0.005 0.11 -10000 0 -0.44 31 31
ARR3 -0.006 0.022 -10000 0 -10000 0 0
absorption of light 0 0 -10000 0 -10000 0 0
cGMP/Cone CNG Channel 0.016 0.07 -10000 0 -0.27 29 29
mol:Pi 0.027 0.084 -10000 0 -0.28 37 37
Cone CNG Channel 0.028 0.076 -10000 0 -0.24 36 36
mol:all-trans-retinal 0 0 -10000 0 -10000 0 0
mol:K + 0.009 0.038 -10000 0 -0.44 2 2
RGS9 0.008 0.095 -10000 0 -0.44 23 23
PDE6C -0.006 0.02 -10000 0 -10000 0 0
GNGT2 0.015 0.074 -10000 0 -0.44 14 14
mol:cGMP (4 units) 0 0 -10000 0 -10000 0 0
PDE6H -0.015 0.012 -10000 0 -10000 0 0
EPO signaling pathway

Figure S72.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S72.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.017 0.056 -10000 0 -10000 0 0
CRKL -0.004 0.06 0.19 10 -0.22 16 26
mol:DAG 0.013 0.034 -10000 0 -0.28 1 1
HRAS -0.012 0.065 0.28 5 -0.26 2 7
MAPK8 0.011 0.069 0.18 79 -0.26 1 80
RAP1A -0.005 0.062 0.19 10 -0.24 16 26
GAB1 -0.005 0.059 0.18 9 -0.22 16 25
MAPK14 0.011 0.068 0.18 78 -10000 0 78
EPO 0.021 0.019 -10000 0 -10000 0 0
PLCG1 0.013 0.034 -10000 0 -0.28 1 1
EPOR/TRPC2/IP3 Receptors 0.026 0.03 -10000 0 -0.38 2 2
RAPGEF1 0.026 0.02 -10000 0 -0.44 1 1
EPO/EPOR (dimer)/SOCS3 0.046 0.042 -10000 0 -0.29 5 5
GAB1/SHC/GRB2/SOS1 0.041 0.059 0.26 1 -0.25 4 5
EPO/EPOR (dimer) 0.035 0.028 0.19 1 -0.32 1 2
IRS2 -0.009 0.048 0.16 2 -0.23 13 15
STAT1 0.024 0.052 -10000 0 -0.38 2 2
STAT5B 0.022 0.046 -10000 0 -0.27 1 1
cell proliferation 0.011 0.074 0.18 83 -0.24 1 84
GAB1/SHIP/PIK3R1/SHP2/SHC 0.021 0.081 -10000 0 -0.29 15 15
TEC -0.004 0.06 0.19 10 -0.22 16 26
SOCS3 0.024 0.041 -10000 0 -0.44 4 4
STAT1 (dimer) 0.023 0.052 -10000 0 -0.37 2 2
JAK2 0.015 0.078 -10000 0 -0.45 15 15
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
EPO/EPOR (dimer)/JAK2 0.06 0.062 -10000 0 -0.23 16 16
EPO/EPOR 0.035 0.028 0.19 1 -0.32 1 2
LYN 0.023 0.011 -10000 0 -10000 0 0
TEC/VAV2 0.015 0.073 -10000 0 -0.22 38 38
elevation of cytosolic calcium ion concentration 0.025 0.03 -10000 0 -0.38 2 2
SHC1 0.026 0.004 -10000 0 -10000 0 0
EPO/EPOR (dimer)/LYN 0.045 0.03 -10000 0 -10000 0 0
mol:IP3 0.013 0.034 -10000 0 -0.28 1 1
PI3K regualtory subunit polypeptide 1/IRS2/SHIP 0.014 0.071 -10000 0 -0.23 24 24
SH2B3 0.026 0.014 -10000 0 -10000 0 0
NFKB1 0.01 0.068 0.18 76 -0.26 1 77
EPO/EPOR (dimer)/JAK2/SOCS3 0.003 0.052 -10000 0 -0.24 20 20
PTPN6 0.004 0.06 0.3 2 -0.23 16 18
TEC/VAV2/GRB2 0.027 0.078 0.26 2 -0.22 38 40
EPOR 0.026 0.03 -10000 0 -0.38 2 2
INPP5D 0.006 0.095 -10000 0 -0.44 24 24
mol:GDP 0.04 0.059 0.26 1 -0.25 4 5
SOS1 0.027 0.002 -10000 0 -10000 0 0
PLCG2 0.015 0.076 -10000 0 -0.44 15 15
CRKL/CBL/C3G 0.037 0.061 0.26 2 -0.22 16 18
VAV2 -0.013 0.073 0.19 9 -0.22 38 47
CBL -0.005 0.06 0.19 9 -0.23 15 24
SHC/Grb2/SOS1 0.034 0.051 -10000 0 -0.22 16 16
STAT5A 0.022 0.046 -10000 0 -0.27 1 1
GRB2 0.026 0.004 -10000 0 -10000 0 0
STAT5 (dimer) 0.036 0.063 -10000 0 -0.31 6 6
LYN/PLCgamma2 0.028 0.053 -10000 0 -0.32 12 12
PTPN11 0.022 0.044 -10000 0 -0.44 5 5
BTK -0.016 0.077 0.2 6 -0.24 38 44
BCL2 0.01 0.14 -10000 0 -0.72 15 15
PDGFR-alpha signaling pathway

Figure S73.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S73.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRA 0.014 0.086 -10000 0 -0.44 18 18
PDGF/PDGFRA/CRKL 0.028 0.063 -10000 0 -0.3 18 18
positive regulation of JUN kinase activity 0.055 0.055 -10000 0 -0.24 17 17
CRKL 0.026 0.005 -10000 0 -10000 0 0
PDGF/PDGFRA/Caveolin-3 0.024 0.064 -10000 0 -0.31 18 18
AP1 -0.011 0.16 0.29 4 -0.66 24 28
mol:IP3 -0.016 0.053 -10000 0 -0.33 15 15
PLCG1 -0.016 0.053 -10000 0 -0.33 15 15
PDGF/PDGFRA/alphaV Integrin 0.022 0.082 -10000 0 -0.32 28 28
RAPGEF1 0.026 0.02 -10000 0 -0.44 1 1
CRK 0.022 0.011 -10000 0 -10000 0 0
mol:Ca2+ -0.016 0.053 -10000 0 -0.33 15 15
CAV3 -0.01 0.019 -10000 0 -10000 0 0
CAV1 0.024 0.041 -10000 0 -0.44 4 4
SHC/Grb2/SOS1 0.057 0.056 -10000 0 -0.24 17 17
PDGF/PDGFRA/Shf 0.025 0.079 -10000 0 -0.31 27 27
FOS -0.032 0.15 0.3 16 -0.66 24 40
JUN -0.012 0.037 -10000 0 -0.35 4 4
oligodendrocyte development 0.022 0.081 -10000 0 -0.32 28 28
GRB2 0.026 0.004 -10000 0 -10000 0 0
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
mol:DAG -0.016 0.053 -10000 0 -0.33 15 15
PDGF/PDGFRA 0.014 0.086 -10000 0 -0.44 18 18
actin cytoskeleton reorganization 0.029 0.062 -10000 0 -0.31 17 17
SRF -0.008 0.015 0.23 1 -10000 0 1
SHC1 0.026 0.004 -10000 0 -10000 0 0
PI3K 0.042 0.062 -10000 0 -0.26 21 21
PDGF/PDGFRA/Crk/C3G 0.037 0.058 -10000 0 -0.26 18 18
JAK1 -0.009 0.056 -10000 0 -0.31 17 17
ELK1/SRF 0.016 0.084 0.15 125 -0.26 14 139
SHB 0.026 0.005 -10000 0 -10000 0 0
SHF 0.023 0.063 -10000 0 -0.44 9 9
CSNK2A1 0.013 0.023 -10000 0 -10000 0 0
GO:0007205 -0.014 0.057 -10000 0 -0.35 15 15
SOS1 0.027 0.002 -10000 0 -10000 0 0
Ras protein signal transduction 0.055 0.055 -10000 0 -0.24 17 17
PDGF/PDGFRA/SHB 0.029 0.062 -10000 0 -0.31 17 17
PDGF/PDGFRA/Caveolin-1 0.028 0.068 -10000 0 -0.32 18 18
ITGAV 0.017 0.065 -10000 0 -0.44 11 11
ELK1 -0.014 0.053 0.24 2 -0.31 15 17
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
PDGF/PDGFRA/Crk 0.023 0.063 -10000 0 -0.3 18 18
JAK-STAT cascade -0.009 0.056 -10000 0 -0.31 17 17
cell proliferation 0.025 0.079 -10000 0 -0.31 27 27
Regulation of p38-alpha and p38-beta

Figure S74.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S74.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
RIP1/MEKK3 0.033 0.02 -10000 0 -0.27 2 2
response to insulin stimulus 0 0 -10000 0 -10000 0 0
RIPK1 0.026 0.004 -10000 0 -10000 0 0
response to stress 0 0 -10000 0 -10000 0 0
MAP2K6 0.018 0.062 -10000 0 -0.44 10 10
mol:GTP 0 0 -10000 0 -10000 0 0
MAP2K4 0.021 0.022 -10000 0 -0.44 1 1
RAC1-CDC42/GTP/PAK family 0.01 0.027 -10000 0 -0.26 4 4
response to UV 0 0 -10000 0 -10000 0 0
YES1 0.019 0.035 -10000 0 -0.44 3 3
interleukin-1 receptor activity 0 0 -10000 0 -10000 0 0
tumor necrosis factor receptor activity 0 0 -10000 0 -10000 0 0
MAP3K3 0.024 0.028 -10000 0 -0.44 2 2
FYN 0.023 0.04 -10000 0 -0.44 4 4
MAP3K12 0.022 0.049 -10000 0 -0.44 6 6
FGR 0.01 0.088 -10000 0 -0.44 20 20
p38 alpha/TAB1 -0.065 0.13 -10000 0 -0.34 76 76
PRKG1 0.003 0.1 -10000 0 -0.44 29 29
DUSP8 0.023 0.04 -10000 0 -0.44 4 4
PGK/cGMP/p38 alpha -0.03 0.16 0.2 3 -0.37 75 78
apoptosis -0.062 0.12 -10000 0 -0.32 76 76
RAL/GTP 0.033 0.011 -10000 0 -10000 0 0
LYN 0.023 0.009 -10000 0 -10000 0 0
DUSP1 0.026 0.037 -10000 0 -0.44 3 3
PAK1 0.026 0.004 -10000 0 -10000 0 0
SRC 0.015 0.023 -10000 0 -0.44 1 1
RAC1/OSM/MEKK3/MKK3 0.05 0.038 -10000 0 -0.26 3 3
TRAF6 0.025 0.02 -10000 0 -0.44 1 1
RAC1 0.024 0.008 -10000 0 -10000 0 0
epidermal growth factor receptor activity 0 0 -10000 0 -10000 0 0
mol:LPS 0 0 -10000 0 -10000 0 0
mol:cGMP 0 0 -10000 0 -10000 0 0
CCM2 0.024 0.021 -10000 0 -0.44 1 1
RAC1-CDC42/GTP 0.028 0.029 -10000 0 -0.27 4 4
MAPK11 -0.009 0.16 0.27 20 -0.4 45 65
BLK -0.021 0.14 -10000 0 -0.44 54 54
HCK 0.006 0.071 -10000 0 -0.44 13 13
MAP2K3 0.022 0.01 -10000 0 -10000 0 0
DUSP16 0.026 0.005 -10000 0 -10000 0 0
DUSP10 0.025 0.02 -10000 0 -0.44 1 1
TRAF6/MEKK3 0.031 0.021 -10000 0 -0.24 3 3
MAP3K7IP1 0 0 -10000 0 -10000 0 0
MAPK14 -0.022 0.17 0.22 24 -0.38 69 93
positive regulation of innate immune response -0.023 0.19 0.28 20 -0.46 53 73
LCK 0.014 0.085 -10000 0 -0.44 18 18
p38alpha-beta/MKP7 -0.014 0.19 0.3 12 -0.45 49 61
p38alpha-beta/MKP5 -0.013 0.19 0.3 14 -0.45 49 63
PGK/cGMP 0.003 0.074 -10000 0 -0.32 29 29
PAK2 0.026 0.02 -10000 0 -0.44 1 1
p38alpha-beta/MKP1 -0.013 0.19 0.31 14 -0.44 52 66
CDC42 0.022 0.04 -10000 0 -0.44 4 4
RALB 0.027 0.001 -10000 0 -10000 0 0
RALA 0.024 0.008 -10000 0 -10000 0 0
PAK3 0.01 0.025 -10000 0 -10000 0 0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)

Figure S75.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S75.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MET/RANBP9 0.037 0.027 -10000 0 -0.57 1 1
CRKL 0.013 0.11 0.26 9 -0.43 17 26
mol:PIP3 0.001 0.038 -10000 0 -0.82 1 1
AKT1 -0.007 0.038 -10000 0 -0.72 1 1
PTK2B 0.019 0.03 -10000 0 -0.44 2 2
RAPGEF1 0.015 0.1 0.3 6 -0.42 17 23
RANBP10 0.026 0.003 -10000 0 -10000 0 0
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
HGF/MET/SHIP2 0.033 0.077 -10000 0 -0.27 32 32
MAP3K5 0.004 0.13 0.35 4 -0.46 24 28
HGF/MET/CIN85/CBL/ENDOPHILINS 0.046 0.076 -10000 0 -0.25 33 33
AP1 0.017 0.065 0.16 4 -0.26 22 26
mol:SU11274 0 0 -10000 0 -10000 0 0
SHC1 0.026 0.004 -10000 0 -10000 0 0
apoptosis -0.056 0.26 -10000 0 -0.75 66 66
STAT3 (dimer) -0.005 0.068 -10000 0 -0.36 9 9
GAB1/CRKL/SHP2/PI3K 0.046 0.11 0.3 3 -0.44 17 20
INPP5D 0.006 0.095 -10000 0 -0.44 24 24
CBL/CRK 0.033 0.1 0.28 5 -0.41 16 21
PTPN11 0.022 0.044 -10000 0 -0.44 5 5
GO:0007205 0 0 -10000 0 -10000 0 0
PLCG1 0.015 0.023 -10000 0 -0.44 1 1
PTEN 0.025 0.006 -10000 0 -10000 0 0
ELK1 0.005 0.096 0.3 45 -0.43 1 46
mol:SU5416 0 0 -10000 0 -10000 0 0
SHP2/GRB2/SOS1GAB1 -0.004 0.056 -10000 0 -0.25 14 14
PAK1 -0.009 0.039 0.28 1 -0.69 1 2
HGF/MET/RANBP10 0.034 0.076 -10000 0 -0.27 31 31
HRAS 0.005 0.085 -10000 0 -0.79 2 2
DOCK1 0.014 0.1 0.29 4 -0.43 16 20
GAB1 0.007 0.1 -10000 0 -0.45 17 17
CRK 0.012 0.1 0.26 8 -0.44 15 23
mol:PHA665752 0 0 -10000 0 -10000 0 0
mol:GDP -0.002 0.12 -10000 0 -0.46 33 33
JUN 0.023 0.04 -10000 0 -0.44 4 4
EntrezGene:200958 0 0 -10000 0 -10000 0 0
HGF/MET -0.021 0.051 -10000 0 -0.19 33 33
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
cell morphogenesis 0.026 0.12 0.26 34 -0.4 13 47
GRB2/SHC -0.002 0.063 -10000 0 -0.22 9 9
FOS 0.013 0.082 -10000 0 -0.44 17 17
GLMN -0.006 0.048 -10000 0 -0.27 18 18
cell motility 0.005 0.096 0.3 45 -0.43 1 46
HGF/MET/MUC20 0.019 0.07 -10000 0 -0.27 31 31
cell migration -0.002 0.062 -10000 0 -0.22 9 9
GRB2 0.026 0.004 -10000 0 -10000 0 0
CBL 0.026 0.004 -10000 0 -10000 0 0
MET/RANBP10 0.037 0.017 -10000 0 -0.32 1 1
HGF/MET/Paxillin/FAK1/FAK12/RasGAP 0.001 0.067 -10000 0 -0.25 31 31
MET/MUC20 0.018 0.015 -10000 0 -0.32 1 1
RAP1B 0.012 0.1 0.31 7 -0.39 17 24
RAP1A 0.011 0.099 0.29 6 -0.4 16 22
HGF/MET/RANBP9 0.034 0.078 -10000 0 -0.28 31 31
RAF1 0.007 0.085 -10000 0 -0.73 2 2
STAT3 -0.005 0.069 -10000 0 -0.37 9 9
cell proliferation 0.005 0.096 0.29 4 -0.35 25 29
RPS6KB1 -0.007 0.057 -10000 0 -0.27 19 19
MAPK3 -0.011 0.083 0.4 15 -10000 0 15
MAPK1 0.019 0.16 0.65 31 -10000 0 31
RANBP9 0.026 0.02 -10000 0 -0.44 1 1
MAPK8 0.01 0.12 0.34 4 -0.39 28 32
SRC -0.008 0.062 0.19 5 -0.33 9 14
PI3K -0.003 0.068 -10000 0 -0.19 34 34
MET/Glomulin -0.019 0.057 -10000 0 -0.2 26 26
SOS1 0.027 0.002 -10000 0 -10000 0 0
MAP2K1 0.005 0.084 0.3 1 -0.74 2 3
MET 0.025 0.021 -10000 0 -0.44 1 1
MAP4K1 0.006 0.14 0.29 3 -0.5 23 26
PTK2 0.021 0.022 -10000 0 -0.44 1 1
MAP2K2 0.005 0.083 0.3 1 -0.58 3 4
BAD -0.01 0.04 -10000 0 -0.55 2 2
MAP2K4 -0.001 0.12 0.31 5 -0.41 24 29
SHP2/GRB2/SOS1/GAB1 0.035 0.099 -10000 0 -0.4 16 16
INPPL1 0.025 0.02 -10000 0 -0.44 1 1
PXN 0.027 0.002 -10000 0 -10000 0 0
SH3KBP1 0.024 0.028 -10000 0 -0.44 2 2
HGS -0.023 0.047 -10000 0 -0.18 32 32
PLCgamma1/PKC 0.011 0.017 -10000 0 -0.32 1 1
HGF 0.001 0.11 -10000 0 -0.44 31 31
RASA1 0.024 0.028 -10000 0 -0.44 2 2
NCK1 0.025 0.028 -10000 0 -0.44 2 2
PTPRJ 0.025 0.02 -10000 0 -0.44 1 1
NCK/PLCgamma1 0.016 0.052 -10000 0 -0.19 26 26
PDPK1 -0.003 0.041 -10000 0 -0.76 1 1
HGF/MET/SHIP 0.021 0.098 -10000 0 -0.28 53 53
RXR and RAR heterodimerization with other nuclear receptor

Figure S76.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S76.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 -0.016 0.17 0.81 3 -1.2 9 12
VDR 0.026 0.02 -10000 0 -0.44 1 1
FAM120B 0.025 0.02 -10000 0 -0.44 1 1
RXRs/LXRs/DNA/9cRA 0.021 0.071 -10000 0 -0.29 23 23
RXRs/LXRs/DNA/Oxysterols 0.019 0.1 -10000 0 -0.42 26 26
MED1 0.024 0.028 -10000 0 -0.44 2 2
mol:9cRA 0.001 0.011 -10000 0 -0.071 2 2
RARs/THRs/DNA/Src-1 -0.011 0.097 -10000 0 -0.24 78 78
RXRs/NUR77 0.068 0.052 -10000 0 -0.29 3 3
RXRs/PPAR 0.019 0.047 -10000 0 -0.26 9 9
NCOR2 0.024 0.035 -10000 0 -0.44 3 3
VDR/VDR/Vit D3 0.019 0.014 -10000 0 -0.32 1 1
RARs/VDR/DNA/Vit D3 0.051 0.055 -10000 0 -0.25 16 16
RARA 0.025 0.02 -10000 0 -0.44 1 1
NCOA1 0.026 0.02 -10000 0 -0.44 1 1
VDR/VDR/DNA 0.026 0.02 -10000 0 -0.44 1 1
RARs/RARs/DNA/9cRA 0.036 0.052 -10000 0 -0.25 15 15
RARG 0.021 0.048 -10000 0 -0.44 6 6
RPS6KB1 -0.004 0.096 0.54 9 -0.42 14 23
RARs/THRs/DNA/SMRT -0.012 0.1 -10000 0 -0.24 78 78
THRA 0.025 0.02 -10000 0 -0.44 1 1
mol:Bile acids 0 0 -10000 0 -10000 0 0
VDR/Vit D3/DNA 0.019 0.014 -10000 0 -0.32 1 1
RXRs/PPAR/9cRA/PGJ2/DNA 0.052 0.055 0.29 6 -0.16 24 30
NR1H4 -0.019 0.15 -10000 0 -0.44 58 58
RXRs/LXRs/DNA 0.075 0.072 -10000 0 -0.22 24 24
NR1H2 0.025 0.027 -10000 0 -0.47 1 1
NR1H3 0.026 0.02 -10000 0 -10000 0 0
RXRs/VDR/DNA/Vit D3 0.06 0.044 -10000 0 -0.2 5 5
NR4A1 0.031 0.028 -10000 0 -0.44 1 1
mol:ATRA 0 0 -10000 0 -10000 0 0
RXRs/FXR/9cRA/MED1 -0.005 0.082 -10000 0 -0.22 59 59
RXRG 0.025 0.031 -10000 0 -0.44 1 1
RXR alpha/CCPG 0.037 0.023 -10000 0 -0.33 1 1
RXRA 0.025 0.027 -10000 0 -0.45 1 1
RXRB 0.026 0.019 -10000 0 -10000 0 0
THRB -0.026 0.15 -10000 0 -0.44 65 65
PPARG 0.02 0.052 -10000 0 -0.44 7 7
PPARD 0.026 0.02 -10000 0 -0.44 1 1
TNF -0.009 0.2 -10000 0 -1 20 20
mol:Oxysterols 0.001 0.01 -10000 0 -10000 0 0
cholesterol transport 0.019 0.1 -10000 0 -0.42 26 26
PPARA 0.024 0.021 -10000 0 -0.44 1 1
mol:Vit D3 0 0 -10000 0 -10000 0 0
RARB 0.019 0.063 -10000 0 -0.44 10 10
RXRs/NUR77/BCL2 0.006 0.046 -10000 0 -0.23 11 11
SREBF1 0.007 0.1 -10000 0 -0.89 3 3
RXRs/RXRs/DNA/9cRA 0.052 0.054 0.28 6 -0.16 24 30
ABCA1 0.004 0.15 -10000 0 -1 9 9
RARs/THRs 0.032 0.12 -10000 0 -0.25 75 75
RXRs/FXR 0.038 0.11 0.21 1 -0.25 60 61
BCL2 0.015 0.05 -10000 0 -0.44 6 6
LPA4-mediated signaling events

Figure S77.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S77.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ADCY4 -0.011 0.022 -10000 0 -0.27 4 4
ADCY5 -0.044 0.083 -10000 0 -0.27 65 65
ADCY6 -0.009 0.001 -10000 0 -10000 0 0
ADCY7 -0.01 0.011 -10000 0 -0.27 1 1
ADCY1 -0.015 0.044 0.22 5 -0.27 11 16
ADCY2 -0.028 0.067 -10000 0 -0.27 40 40
ADCY3 -0.009 0.001 -10000 0 -10000 0 0
ADCY8 -0.011 0.012 0.22 1 -10000 0 1
PRKCE -0.006 0 -10000 0 -10000 0 0
ADCY9 -0.01 0.016 -10000 0 -0.27 2 2
mol:DAG 0 0 -10000 0 -10000 0 0
cAMP biosynthetic process -0.003 0.074 0.19 24 -0.2 17 41
Syndecan-3-mediated signaling events

Figure S78.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S78.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CTTN 0.026 0.004 -10000 0 -10000 0 0
Syndecan-3/Src/Cortactin 0.009 0.091 -10000 0 -0.36 18 18
Syndecan-3/Neurocan 0.006 0.091 -10000 0 -0.39 26 26
POMC 0.012 0.085 -10000 0 -0.44 18 18
EGFR 0.02 0.045 -10000 0 -0.44 5 5
Syndecan-3/EGFR 0.004 0.092 -10000 0 -0.38 27 27
AGRP -0.001 0.024 -10000 0 -10000 0 0
NCSTN 0.026 0.004 -10000 0 -10000 0 0
PSENEN 0.025 0.02 -10000 0 -0.44 1 1
RP11-540L11.1 0 0 -10000 0 -10000 0 0
APH1B 0.022 0.04 -10000 0 -0.44 4 4
APH1A 0.026 0.004 -10000 0 -10000 0 0
NCAN 0.004 0.026 -10000 0 -10000 0 0
long-term memory 0.021 0.093 -10000 0 -0.36 28 28
Syndecan-3/IL8 -0.012 0.12 -10000 0 -0.4 31 31
PSEN1 0.025 0.007 -10000 0 -10000 0 0
Src/Cortactin 0.022 0.024 -10000 0 -0.32 1 1
FYN 0.023 0.04 -10000 0 -0.44 4 4
limb bud formation -0.008 0.087 -10000 0 -0.4 26 26
MC4R -0.004 0.021 -10000 0 -10000 0 0
SRC 0.015 0.023 -10000 0 -0.44 1 1
PTN 0.007 0.094 -10000 0 -0.44 23 23
FGFR/FGF/Syndecan-3 -0.008 0.088 -10000 0 -0.4 26 26
neuron projection morphogenesis 0.045 0.12 0.32 2 -0.37 17 19
Syndecan-3/AgRP 0.005 0.09 -10000 0 -0.39 26 26
Syndecan-3/AgRP/MC4R 0.011 0.088 -10000 0 -0.37 26 26
Fyn/Cortactin 0.035 0.032 -10000 0 -0.32 4 4
SDC3 -0.008 0.089 -10000 0 -0.41 26 26
GO:0007205 0 0 -10000 0 -10000 0 0
positive regulation of leukocyte migration -0.011 0.12 -10000 0 -0.39 31 31
IL8 -0.017 0.15 -10000 0 -0.44 61 61
Syndecan-3/Fyn/Cortactin 0.022 0.095 -10000 0 -0.37 28 28
Syndecan-3/CASK -0.009 0.085 -10000 0 -0.38 28 28
alpha-MSH/MC4R 0.017 0.063 -10000 0 -0.31 18 18
Gamma Secretase 0.065 0.041 -10000 0 -0.24 5 5
Regulation of Androgen receptor activity

Figure S79.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S79.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 -0.013 0.014 -10000 0 -0.32 1 1
SMARCC1 0.01 0.017 -10000 0 -0.33 1 1
REL 0.025 0.035 -10000 0 -0.44 3 3
HDAC7 -0.031 0.072 -10000 0 -0.38 10 10
JUN 0.022 0.04 -10000 0 -0.44 4 4
EP300 0.024 0.029 -10000 0 -0.44 2 2
KAT2B 0.012 0.078 -10000 0 -0.44 16 16
KAT5 0.025 0.02 -10000 0 -0.44 1 1
MAPK14 -0.003 0.045 -10000 0 -0.34 9 9
FOXO1 0.02 0.011 -10000 0 -10000 0 0
T-DHT/AR 0.006 0.087 -10000 0 -0.35 14 14
MAP2K6 0.015 0.065 -10000 0 -0.46 10 10
BRM/BAF57 0.028 0.041 -10000 0 -0.32 5 5
MAP2K4 0.018 0.025 -10000 0 -0.44 1 1
SMARCA2 0.018 0.043 -10000 0 -0.45 4 4
PDE9A -0.076 0.29 -10000 0 -0.8 67 67
NCOA2 0.018 0.049 -10000 0 -0.44 6 6
CEBPA 0.013 0.078 -10000 0 -0.44 16 16
EHMT2 0.023 0.023 -10000 0 -0.44 1 1
cell proliferation 0.037 0.14 0.3 30 -0.4 18 48
NR0B1 -0.001 0.024 -10000 0 -10000 0 0
EGR1 0.018 0.059 -10000 0 -0.45 8 8
RXRs/9cRA 0.041 0.033 -10000 0 -0.25 2 2
AR/RACK1/Src 0.052 0.1 0.26 10 -0.3 11 21
AR/GR -0.008 0.081 0.23 1 -0.26 40 41
GNB2L1 0.027 0.005 -10000 0 -10000 0 0
PKN1 0.024 0.034 -10000 0 -0.44 3 3
RCHY1 0.025 0.02 -10000 0 -0.44 1 1
epidermal growth factor receptor activity 0 0.001 -10000 0 -10000 0 0
MAPK8 0.002 0.024 -10000 0 -0.32 2 2
T-DHT/AR/TIF2/CARM1 0.004 0.071 -10000 0 -0.31 15 15
SRC 0.009 0.079 0.18 76 -0.28 11 87
NR3C1 0.013 0.081 -10000 0 -0.44 17 17
KLK3 -0.14 0.34 -10000 0 -1.1 57 57
APPBP2 0.02 0.042 -10000 0 -0.44 4 4
TRIM24 0.021 0.016 -10000 0 -10000 0 0
T-DHT/AR/TIP60 -0.007 0.065 0.23 4 -0.34 10 14
TMPRSS2 -0.024 0.16 -10000 0 -0.58 35 35
RXRG 0.015 0.033 -10000 0 -0.44 1 1
mol:9cRA -0.001 0.002 -10000 0 -10000 0 0
RXRA 0.025 0.02 -10000 0 -0.44 1 1
RXRB 0.026 0.003 -10000 0 -10000 0 0
CARM1 0.026 0.02 -10000 0 -0.44 1 1
NR2C2 0.025 0.02 -10000 0 -0.44 1 1
KLK2 0.028 0.075 0.28 2 -0.37 4 6
AR -0.01 0.062 -10000 0 -0.26 28 28
SENP1 0.025 0.02 -10000 0 -0.44 1 1
HSP90AA1 0.024 0.021 -10000 0 -0.44 1 1
MDM2 0.027 0.03 -10000 0 -0.44 2 2
SRY 0.002 0.009 0.029 50 -10000 0 50
GATA2 0.011 0.086 -10000 0 -0.44 19 19
MYST2 0 0.001 -10000 0 -10000 0 0
HOXB13 -0.001 0.12 -10000 0 -0.41 40 40
T-DHT/AR/RACK1/Src 0.057 0.11 0.19 138 -0.31 11 149
positive regulation of transcription 0.011 0.085 -10000 0 -0.44 19 19
DNAJA1 0.024 0.014 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.014 0.035 -10000 0 -0.4 3 3
NCOA1 0.024 0.027 -10000 0 -0.48 1 1
SPDEF -0.056 0.19 -10000 0 -0.44 105 105
T-DHT/AR/TIF2 -0.008 0.1 0.28 5 -0.45 14 19
T-DHT/AR/Hsp90 -0.008 0.062 0.22 4 -0.32 11 15
GSK3B 0.024 0.029 -10000 0 -0.44 2 2
NR2C1 0.026 0.02 -10000 0 -0.44 1 1
mol:T-DHT -0.019 0.042 -10000 0 -0.3 10 10
SIRT1 0.022 0.04 -10000 0 -0.44 4 4
ZMIZ2 0.026 0.023 -10000 0 -0.44 1 1
POU2F1 0.02 0.063 -10000 0 -0.35 10 10
T-DHT/AR/DAX-1 -0.018 0.06 0.33 1 -0.32 10 11
CREBBP 0.026 0.004 -10000 0 -10000 0 0
SMARCE1 0.021 0.025 -10000 0 -0.44 1 1
Aurora B signaling

Figure S80.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S80.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Condensin I complex -0.008 0.087 -9999 0 -0.31 26 26
STMN1 -0.012 0.045 -9999 0 -0.32 11 11
Aurora B/RasGAP/Survivin 0.043 0.03 -9999 0 -0.29 2 2
Chromosomal passenger complex/Cul3 protein complex -0.015 0.079 -9999 0 -0.23 45 45
BIRC5 0.027 0.007 -9999 0 -10000 0 0
DES -0.16 0.31 -9999 0 -0.62 172 172
Aurora C/Aurora B/INCENP 0.034 0.052 -9999 0 -0.24 16 16
Aurora B/TACC1 0.024 0.034 -9999 0 -0.27 6 6
Aurora B/PP2A 0.032 0.016 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
CBX5 0.006 0.011 -9999 0 -0.25 1 1
mitotic metaphase/anaphase transition 0.001 0.004 -9999 0 -10000 0 0
NDC80 -0.01 0.039 -9999 0 -0.32 8 8
Cul3 protein complex 0.033 0.095 -9999 0 -0.28 46 46
KIF2C 0.009 0.046 -9999 0 -0.36 6 6
PEBP1 0.028 0.003 -9999 0 -10000 0 0
KIF20A 0.026 0.029 -9999 0 -0.44 2 2
mol:GDP 0 0 -9999 0 -10000 0 0
Aurora B/RasGAP 0.031 0.026 -9999 0 -0.32 2 2
SEPT1 0.017 0.069 -9999 0 -0.44 12 12
SMC2 0.02 0.056 -9999 0 -0.44 8 8
SMC4 0.014 0.076 -9999 0 -0.44 15 15
NSUN2/NPM1/Nucleolin -0.073 0.2 -9999 0 -0.5 99 99
PSMA3 0.025 0.007 -9999 0 -10000 0 0
G2/M transition of mitotic cell cycle -0.001 0.003 -9999 0 -10000 0 0
H3F3B 0.011 0.005 -9999 0 -10000 0 0
AURKB 0.022 0.012 -9999 0 -10000 0 0
AURKC 0.012 0.079 -9999 0 -0.44 16 16
CDCA8 0.027 0.005 -9999 0 -10000 0 0
cytokinesis 0.001 0.068 -9999 0 -0.28 22 22
Aurora B/Septin1 -0.003 0.11 -9999 0 -0.29 36 36
AURKA 0.016 0.014 -9999 0 -10000 0 0
INCENP 0.027 0.005 -9999 0 -10000 0 0
KLHL13 0 0.13 -9999 0 -0.44 45 45
BUB1 0.028 0.021 -9999 0 -0.45 1 1
hSgo1/Aurora B/Survivin 0.039 0.034 -9999 0 -0.24 5 5
EVI5 0.019 0.056 -9999 0 -0.45 8 8
RhoA/GTP 0.034 0.064 -9999 0 -0.23 2 2
SGOL1 0.022 0.044 -9999 0 -0.44 5 5
CENPA 0.025 0.061 -9999 0 -0.2 11 11
NCAPG 0.023 0.035 -9999 0 -0.44 3 3
Aurora B/HC8 Proteasome 0.032 0.016 -9999 0 -10000 0 0
NCAPD2 0.026 0.005 -9999 0 -10000 0 0
Aurora B/PP1-gamma 0.032 0.022 -9999 0 -0.32 1 1
RHOA 0.025 0.02 -9999 0 -0.44 1 1
NCAPH 0.026 0.02 -9999 0 -0.44 1 1
NPM1 -0.052 0.17 -9999 0 -0.36 104 104
RASA1 0.024 0.028 -9999 0 -0.44 2 2
KLHL9 0.025 0.02 -9999 0 -0.44 1 1
mitotic prometaphase 0 0.002 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.032 0.016 -9999 0 -10000 0 0
PPP1CC 0.026 0.02 -9999 0 -0.44 1 1
Centraspindlin 0.029 0.063 -9999 0 -0.23 2 2
RhoA/GDP 0.019 0.014 -9999 0 -0.32 1 1
NSUN2 -0.035 0.11 -9999 0 -0.28 97 97
MYLK 0.002 0.056 -9999 0 -0.32 15 15
KIF23 0.026 0.006 -9999 0 -10000 0 0
VIM -0.008 0.026 -9999 0 -0.32 3 3
RACGAP1 0.027 0.004 -9999 0 -10000 0 0
mitosis 0 0 -9999 0 -10000 0 0
NCL -0.035 0.11 -9999 0 -0.28 100 100
Chromosomal passenger complex 0.008 0.052 -9999 0 -0.19 15 15
Chromosomal passenger complex/EVI5 0.061 0.054 -9999 0 -0.24 8 8
TACC1 0.018 0.049 -9999 0 -0.44 6 6
PPP2R5D 0.026 0.004 -9999 0 -10000 0 0
CUL3 0.025 0.028 -9999 0 -0.44 2 2
response to DNA damage stimulus 0 0 -9999 0 -10000 0 0
Coregulation of Androgen receptor activity

Figure S81.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S81.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NRIP1 0.009 0.061 -10000 0 -0.44 7 7
SVIL 0.017 0.036 -10000 0 -0.44 1 1
ZNF318 0.039 0.046 0.19 49 -10000 0 49
JMJD2C 0.005 0.009 0.04 2 -10000 0 2
T-DHT/AR/Ubc9 0.027 0.069 -10000 0 -0.26 23 23
CARM1 0.021 0.025 -10000 0 -0.44 1 1
PRDX1 0.026 0.02 -10000 0 -0.44 1 1
PELP1 0.023 0.024 -10000 0 -0.44 1 1
CTNNB1 0.018 0.027 -10000 0 -10000 0 0
AKT1 0.028 0.025 -10000 0 -0.44 1 1
PTK2B 0.014 0.035 -10000 0 -0.44 2 2
MED1 0.028 0.033 -10000 0 -0.44 2 2
MAK 0.031 0.072 0.19 49 -0.43 7 56
response to oxidative stress 0.001 0.004 -10000 0 -10000 0 0
HIP1 0.014 0.048 -10000 0 -0.44 4 4
GSN 0.013 0.057 -10000 0 -0.27 11 11
NCOA2 0.015 0.05 -10000 0 -0.45 6 6
NCOA6 0.011 0.03 -10000 0 -0.44 1 1
DNA-PK 0.053 0.049 0.2 30 -0.5 1 31
NCOA4 0.021 0.031 -10000 0 -0.44 2 2
PIAS3 0.018 0.034 -10000 0 -0.44 1 1
cell proliferation 0.015 0.092 0.22 1 -0.52 12 13
XRCC5 0.029 0.023 -10000 0 -0.44 1 1
UBE3A 0.012 0.05 -10000 0 -0.32 5 5
T-DHT/AR/SNURF -0.003 0.12 -10000 0 -0.28 72 72
FHL2 0.028 0.064 -10000 0 -1 1 1
RANBP9 0.016 0.039 -10000 0 -0.44 1 1
JMJD1A 0 0.029 -10000 0 -0.12 31 31
CDK6 0.026 0.007 -10000 0 -10000 0 0
TGFB1I1 0.015 0.045 -10000 0 -0.44 3 3
T-DHT/AR/CyclinD1 0.019 0.073 -10000 0 -0.27 22 22
XRCC6 0.028 0.012 -10000 0 -10000 0 0
T-DHT/AR 0.033 0.083 -10000 0 -0.22 50 50
CTDSP1 0.02 0.027 -10000 0 -0.44 1 1
CTDSP2 0.035 0.03 -10000 0 -10000 0 0
BRCA1 0.017 0.035 -10000 0 -0.44 1 1
TCF4 0.022 0.04 -10000 0 -0.42 3 3
CDKN2A 0.006 0.12 0.17 3 -0.44 37 40
SRF 0.035 0.018 -10000 0 -0.13 1 1
NKX3-1 -0.038 0.19 -10000 0 -0.72 37 37
KLK3 -0.11 0.39 -10000 0 -1.3 50 50
TMF1 0.017 0.05 -10000 0 -0.44 6 6
HNRNPA1 0.032 0.018 -10000 0 -10000 0 0
AOF2 -0.006 0.023 -10000 0 -0.079 50 50
APPL1 -0.007 0.056 0.12 45 -0.32 11 56
T-DHT/AR/Caspase 8 0.032 0.073 -10000 0 -0.26 23 23
AR 0.01 0.097 -10000 0 -0.43 22 22
UBA3 0.02 0.027 -10000 0 -0.44 1 1
PATZ1 0.03 0.019 -10000 0 -10000 0 0
PAWR 0.021 0.025 -10000 0 -0.44 1 1
PRKDC 0.025 0.024 -10000 0 -0.44 1 1
PA2G4 0.032 0.019 -10000 0 -10000 0 0
UBE2I 0.026 0.004 -10000 0 -10000 0 0
T-DHT/AR/Cyclin D3/CDK11 p58 0.03 0.065 -10000 0 -0.23 23 23
RPS6KA3 0.013 0.052 -10000 0 -0.44 4 4
T-DHT/AR/ARA70 0.022 0.072 -10000 0 -0.27 25 25
LATS2 0.023 0.028 -10000 0 -0.44 1 1
T-DHT/AR/PRX1 0.033 0.07 0.17 9 -0.24 23 32
Cyclin D3/CDK11 p58 0.02 0.005 -10000 0 -10000 0 0
VAV3 -0.04 0.16 -10000 0 -0.44 71 71
KLK2 0.006 0.035 -10000 0 -0.33 1 1
CASP8 0.028 0.021 -10000 0 -0.44 1 1
T-DHT/AR/TIF2/CARM1 0.026 0.077 -10000 0 -0.26 24 24
TMPRSS2 -0.003 0.088 -10000 0 -0.49 10 10
CCND1 0.02 0.02 -10000 0 -10000 0 0
PIAS1 0.015 0.039 -10000 0 -10000 0 0
mol:T-DHT -0.001 0.016 -10000 0 -0.063 31 31
CDC2L1 0 0.002 -10000 0 -10000 0 0
PIAS4 0.01 0.058 -10000 0 -0.18 48 48
T-DHT/AR/CDK6 0.028 0.069 -10000 0 -0.26 21 21
CMTM2 0.009 0.095 -10000 0 -0.44 23 23
SNURF -0.027 0.14 -10000 0 -0.44 53 53
ZMIZ1 0.024 0.024 -10000 0 -10000 0 0
CCND3 0.027 0.005 -10000 0 -10000 0 0
TGIF1 0.025 0.019 -10000 0 -10000 0 0
FKBP4 0.016 0.033 -10000 0 -10000 0 0
Class I PI3K signaling events mediated by Akt

Figure S82.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S82.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.007 0.006 -10000 0 -10000 0 0
BAD/BCL-XL/YWHAZ 0.022 0.027 -10000 0 -0.25 2 2
CDKN1B 0.018 0.075 -10000 0 -0.36 15 15
CDKN1A 0.016 0.078 -10000 0 -0.35 18 18
FRAP1 0 0 -10000 0 -10000 0 0
PRKDC 0.022 0.022 -10000 0 -0.44 1 1
FOXO3 0.019 0.069 -10000 0 -0.34 14 14
AKT1 -0.003 0.071 -10000 0 -0.37 18 18
BAD 0.025 0.02 -10000 0 -0.44 1 1
AKT3 0.006 0.043 -10000 0 -0.3 11 11
mol:GTP 0 0 -10000 0 -10000 0 0
FOXO4 0.017 0.077 -10000 0 -0.35 17 17
AKT1/ASK1 0.034 0.1 0.23 1 -0.35 20 21
BAD/YWHAZ 0.043 0.031 -10000 0 -0.27 3 3
RICTOR 0.009 0.087 -10000 0 -0.44 20 20
RAF1 0.026 0.004 -10000 0 -10000 0 0
JNK cascade -0.031 0.097 0.34 20 -10000 0 20
TSC1 0.016 0.078 -10000 0 -0.35 18 18
YWHAZ 0.021 0.029 -10000 0 -0.44 2 2
AKT1/RAF1 0.038 0.1 0.24 3 -0.36 18 21
EP300 0.024 0.029 -10000 0 -0.44 2 2
mol:GDP 0.02 0.08 -10000 0 -0.36 18 18
mol:PI-3-4-5-P3 0 0 -10000 0 -10000 0 0
TSC2 0.017 0.079 0.19 1 -0.37 16 17
YWHAQ 0.027 0.002 -10000 0 -10000 0 0
TBC1D4 0.002 0.019 -10000 0 -0.26 3 3
MAP3K5 0.024 0.028 -10000 0 -0.44 2 2
MAPKAP1 0.026 0.003 -10000 0 -10000 0 0
negative regulation of cell cycle -0.044 0.096 0.31 13 -0.2 49 62
YWHAH 0.026 0.005 -10000 0 -10000 0 0
AKT1S1 0.017 0.08 -10000 0 -0.37 17 17
CASP9 0.017 0.074 -10000 0 -0.37 14 14
YWHAB 0.015 0.013 -10000 0 -10000 0 0
p27Kip1/KPNA1 0.036 0.1 0.31 6 -0.36 20 26
GBL 0 0 -10000 0 -10000 0 0
PDK1/Src/Hsp90 0.03 0.03 -10000 0 -0.27 1 1
YWHAE 0.022 0.01 -10000 0 -10000 0 0
SRC 0.015 0.023 -10000 0 -0.44 1 1
AKT2/p21CIP1 0.013 0.084 -10000 0 -0.37 14 14
KIAA1303 0 0 -10000 0 -10000 0 0
mTOR/RHEB/GTP/Raptor/GBL 0.014 0.033 -10000 0 -0.27 2 2
CHUK 0.02 0.067 -10000 0 -0.36 11 11
BAD/BCL-XL 0.01 0.075 -10000 0 -0.37 14 14
mTORC2 0.024 0.05 -10000 0 -0.24 19 19
AKT2 0.012 0.013 -10000 0 -0.3 1 1
FOXO1-3a-4/14-3-3 family 0.051 0.13 0.26 51 -0.4 19 70
PDPK1 0.026 0.004 -10000 0 -10000 0 0
MDM2 0.016 0.078 -10000 0 -0.37 15 15
MAPKKK cascade -0.038 0.1 0.36 18 -0.23 3 21
MDM2/Cbp/p300 0.041 0.1 0.26 1 -0.43 10 11
TSC1/TSC2 0.014 0.08 0.26 4 -0.38 15 19
proteasomal ubiquitin-dependent protein catabolic process 0.039 0.098 0.25 1 -0.38 12 13
glucose import 0.024 0.084 0.2 89 -0.24 11 100
mTOR/RHEB/GDP/Raptor/GBL/PRAS40 0.019 0.054 0.17 5 -0.27 8 13
response to stress 0 0 -10000 0 -10000 0 0
SLC2A4 0.024 0.084 0.2 89 -0.24 11 100
GSK3A 0.018 0.077 -10000 0 -0.38 14 14
FOXO1 0.023 0.076 0.19 32 -0.35 12 44
GSK3B 0.016 0.081 -10000 0 -0.36 18 18
SFN 0.025 0.023 -10000 0 -0.44 1 1
G1/S transition of mitotic cell cycle 0.019 0.1 0.27 7 -0.38 16 23
p27Kip1/14-3-3 family 0.044 0.053 0.27 1 -10000 0 1
PRKACA 0.026 0.003 -10000 0 -10000 0 0
KPNA1 0.025 0.028 -10000 0 -0.44 2 2
HSP90AA1 0.024 0.021 -10000 0 -0.44 1 1
YWHAG 0.026 0.005 -10000 0 -10000 0 0
RHEB 0.026 0.005 -10000 0 -10000 0 0
CREBBP 0.026 0.004 -10000 0 -10000 0 0
HIV-1 Nef: Negative effector of Fas and TNF-alpha

Figure S83.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S83.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BAG4 0.022 0.022 -10000 0 -0.44 1 1
Caspase 8 (4 units) 0.017 0.087 -10000 0 -0.38 11 11
NEF -0.009 0.039 -10000 0 -0.16 29 29
NFKBIA 0.022 0.022 -10000 0 -10000 0 0
BIRC3 -0.001 0.082 -10000 0 -0.48 15 15
CYCS -0.008 0.099 0.18 40 -0.29 39 79
RIPK1 0.026 0.004 -10000 0 -10000 0 0
CD247 -0.004 0.11 -10000 0 -0.32 47 47
MAP2K7 0.003 0.12 -10000 0 -0.59 14 14
protein ubiquitination 0.009 0.065 0.42 3 -0.31 5 8
CRADD 0.026 0.003 -10000 0 -10000 0 0
DAXX 0.026 0.003 -10000 0 -10000 0 0
FAS 0.02 0.053 -10000 0 -0.44 7 7
BID -0.011 0.085 0.18 6 -0.28 43 49
NF-kappa-B/RelA/I kappa B alpha 0.045 0.055 -10000 0 -0.26 15 15
TRADD 0.026 0.003 -10000 0 -10000 0 0
MAP3K5 0.024 0.028 -10000 0 -0.44 2 2
CFLAR 0.027 0 -10000 0 -10000 0 0
FADD 0.026 0.004 -10000 0 -10000 0 0
NF-kappa-B/RelA/I kappa B alpha/ubiquitin 0.045 0.055 -10000 0 -0.26 15 15
MAPK8 0.001 0.11 0.42 1 -0.56 14 15
APAF1 0.024 0.034 -10000 0 -0.44 3 3
TRAF1 0.027 0.006 -10000 0 -10000 0 0
TRAF2 0.025 0.02 -10000 0 -0.44 1 1
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG -0.004 0.092 0.19 7 -0.29 45 52
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP1/cIAP2/TRAF1/TRAF2/Ask1/RAIDD 0.015 0.062 -10000 0 -0.36 4 4
CHUK 0.007 0.06 0.21 1 -0.33 5 6
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 0.068 0.048 -10000 0 -0.26 9 9
TCRz/NEF -0.01 0.11 -10000 0 -0.35 47 47
TNF 0.011 0.086 -10000 0 -0.44 19 19
FASLG -0.035 0.16 -10000 0 -0.54 47 47
NFKB1 0.022 0.03 -10000 0 -0.44 1 1
TNFR1A/BAG4/TNF-alpha 0.035 0.06 -10000 0 -0.27 18 18
CASP6 0.019 0.11 -10000 0 -0.5 16 16
CASP7 -0.011 0.12 0.34 2 -0.47 23 25
RELA 0.023 0.022 -10000 0 -10000 0 0
CASP2 0.025 0.006 -10000 0 -10000 0 0
CASP3 -0.016 0.12 0.43 1 -0.5 22 23
TNFRSF1A 0.026 0.005 -10000 0 -10000 0 0
TNFR1A/BAG4 0.033 0.021 -10000 0 -0.32 1 1
CASP8 0.026 0.02 -10000 0 -0.44 1 1
CASP9 0.024 0.021 -10000 0 -0.44 1 1
MAP3K14 0.012 0.062 0.22 1 -0.35 4 5
APAF-1/Caspase 9 -0.001 0.1 -10000 0 -0.4 19 19
BCL2 -0.006 0.1 0.33 2 -0.53 13 15
IL2 signaling events mediated by STAT5

Figure S84.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S84.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GAB2 0.025 0.028 -10000 0 -0.44 2 2
ELF1 0.005 0.084 -10000 0 -0.34 30 30
CCNA2 0.025 0.02 -10000 0 -0.44 1 1
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
JAK3 0.021 0.053 -10000 0 -0.44 7 7
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
JAK1 0.025 0.02 -10000 0 -0.44 1 1
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K 0.004 0.14 -10000 0 -0.45 32 32
SHC1 0.026 0.004 -10000 0 -10000 0 0
SP1 0.008 0.091 -10000 0 -0.33 37 37
IL2RA -0.026 0.16 0.24 1 -0.67 30 31
IL2RB 0.013 0.081 -10000 0 -0.44 17 17
SOS1 0.027 0.002 -10000 0 -10000 0 0
IL2RG 0.018 0.065 -10000 0 -0.44 11 11
G1/S transition of mitotic cell cycle -0.025 0.18 0.37 2 -0.65 40 42
PTPN11 0.023 0.044 -10000 0 -0.44 5 5
CCND2 -0.03 0.18 0.25 3 -0.69 37 40
LCK 0.015 0.085 -10000 0 -0.44 18 18
GRB2 0.026 0.004 -10000 0 -10000 0 0
IL2 0.019 0.011 -10000 0 -10000 0 0
CDK6 0.025 0.007 -10000 0 -10000 0 0
CCND3 0.006 0.12 0.4 1 -0.5 11 12
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Figure S85.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S85.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HIF3A 0.003 0.12 -10000 0 -0.44 36 36
oxygen homeostasis 0 0 -10000 0 -10000 0 0
TCEB2 0.026 0.022 -10000 0 -0.44 1 1
TCEB1 0.023 0.009 -10000 0 -10000 0 0
HIF1A/p53 -0.008 0.085 0.26 1 -0.24 58 59
HIF1A -0.004 0.055 -10000 0 -0.25 24 24
COPS5 0.023 0.009 -10000 0 -10000 0 0
VHL/Elongin B/Elongin C/RBX1/CUL2 0.063 0.038 -10000 0 -0.26 2 2
FIH (dimer) 0.025 0.006 -10000 0 -10000 0 0
CDKN2A 0.001 0.12 -10000 0 -0.44 37 37
ARNT/IPAS 0.02 0.091 -10000 0 -0.32 36 36
HIF1AN 0.025 0.006 -10000 0 -10000 0 0
GNB2L1 0.026 0.005 -10000 0 -10000 0 0
HIF1A/ARNT 0.003 0.07 -10000 0 -0.27 30 30
CUL2 0.027 0.002 -10000 0 -10000 0 0
OS9 0.027 0.002 -10000 0 -10000 0 0
RACK1/Elongin B/Elongin C 0.045 0.025 -10000 0 -0.27 1 1
response to hypoxia 0 0 -10000 0 -10000 0 0
HIF1A/Hsp90 0.008 0.069 0.26 1 -0.26 30 31
PHD1-3/OS9 0.059 0.037 -10000 0 -0.25 5 5
HIF1A/RACK1/Elongin B/Elongin C 0.022 0.073 -10000 0 -0.26 27 27
VHL 0.025 0.02 -10000 0 -0.44 1 1
HSP90AA1 0.024 0.021 -10000 0 -0.44 1 1
HIF1A/JAB1 0.004 0.066 0.26 1 -0.26 25 26
EGLN3 0.022 0.041 -10000 0 -0.44 4 4
EGLN2 0.025 0.02 -10000 0 -0.44 1 1
EGLN1 0.026 0.005 -10000 0 -10000 0 0
TP53 -0.007 0.11 -10000 0 -0.44 34 34
VHL/Elongin B/Elongin C/RBX1/CUL2/HIF1A 0.023 0.082 -10000 0 -0.54 10 10
ARNT 0.025 0.02 -10000 0 -0.44 1 1
ARD1A 0 0 -10000 0 -10000 0 0
RBX1 0.025 0.021 -10000 0 -0.44 1 1
HIF1A/p19ARF -0.007 0.093 0.24 2 -0.24 65 67
Arf6 downstream pathway

Figure S86.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S86.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PLAUR 0.009 0.048 -10000 0 -0.87 1 1
regulation of axonogenesis -0.003 0.048 0.3 11 -10000 0 11
myoblast fusion -0.021 0.036 0.47 2 -10000 0 2
mol:GTP 0.009 0.046 -10000 0 -0.16 35 35
regulation of calcium-dependent cell-cell adhesion -0.029 0.075 0.26 27 -10000 0 27
ARF1/GTP 0.025 0.041 -10000 0 -0.23 3 3
mol:GM1 0.001 0.033 -10000 0 -0.26 2 2
mol:Choline 0.003 0.029 -10000 0 -0.32 3 3
lamellipodium assembly -0.003 0.091 -10000 0 -0.36 31 31
MAPK3 0.011 0.037 -10000 0 -0.3 3 3
ARF6/GTP/NME1/Tiam1 0.03 0.076 -10000 0 -0.26 27 27
ARF1 0.026 0.005 -10000 0 -10000 0 0
ARF6/GDP 0.021 0.037 -10000 0 -0.48 2 2
ARF1/GDP 0.016 0.065 -10000 0 -0.28 10 10
ARF6 0.03 0.026 -10000 0 -0.54 1 1
RAB11A 0.025 0.006 -10000 0 -10000 0 0
TIAM1 0.008 0.1 -10000 0 -0.44 26 26
fibronectin binding 0 0 -10000 0 -10000 0 0
MAPK1 0.013 0.032 -10000 0 -0.3 2 2
actin filament bundle formation -0.019 0.068 0.3 10 -10000 0 10
KALRN 0.012 0.037 -10000 0 -0.29 7 7
RAB11FIP3/RAB11A 0.036 0.018 -10000 0 -0.32 1 1
RhoA/GDP 0.02 0.069 -10000 0 -0.3 10 10
NME1 0.026 0.008 -10000 0 -10000 0 0
Rac1/GDP 0.019 0.064 -10000 0 -0.29 9 9
substrate adhesion-dependent cell spreading 0.009 0.046 -10000 0 -0.16 35 35
cortical actin cytoskeleton organization -0.003 0.09 -10000 0 -0.37 30 30
RAC1 0.024 0.008 -10000 0 -10000 0 0
liver development 0.009 0.046 -10000 0 -0.16 35 35
ARF6/GTP 0.009 0.046 -10000 0 -0.16 35 35
RhoA/GTP 0.025 0.046 -10000 0 -0.38 2 2
mol:GDP 0.001 0.064 -10000 0 -0.23 33 33
ARF6/GTP/RAB11FIP3/RAB11A 0.039 0.043 -10000 0 -0.24 3 3
RHOA 0.025 0.02 -10000 0 -0.44 1 1
PLD1 0.008 0.045 -10000 0 -0.34 4 4
RAB11FIP3 0.025 0.02 -10000 0 -0.44 1 1
tube morphogenesis -0.003 0.091 -10000 0 -0.36 31 31
ruffle organization 0.003 0.048 -10000 0 -0.3 11 11
regulation of epithelial cell migration 0.009 0.046 -10000 0 -0.16 35 35
PLD2 0.012 0.025 -10000 0 -0.26 2 2
PIP5K1A 0.003 0.049 -10000 0 -0.3 11 11
mol:Phosphatidic acid 0.003 0.029 -10000 0 -0.32 3 3
Rac1/GTP -0.004 0.091 -10000 0 -0.36 31 31
mTOR signaling pathway

Figure S87.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S87.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GBL 0 0 -10000 0 -10000 0 0
MKNK1 0.026 0.004 -10000 0 -10000 0 0
mol:PIP3 -0.012 0.041 -10000 0 -0.26 12 12
FRAP1 -0.017 0.12 -10000 0 -0.44 37 37
AKT1 -0.008 0.051 0.15 12 -0.26 13 25
INSR 0.025 0.02 -10000 0 -0.44 1 1
Insulin Receptor/Insulin 0.028 0.015 -10000 0 -0.27 1 1
mol:GTP 0.02 0.056 0.19 3 -0.24 10 13
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA/eIF3/40s Ribosomal subunit -0.001 0.049 -10000 0 -0.22 14 14
TSC2 0.026 0.02 -10000 0 -0.44 1 1
RHEB/GDP 0.012 0.044 -10000 0 -0.22 10 10
TSC1 0.026 0.003 -10000 0 -10000 0 0
Insulin Receptor/IRS1 0.016 0.047 -10000 0 -0.29 12 12
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA 0.008 0.059 -10000 0 -0.24 15 15
mol:GDP 0 0 -10000 0 -10000 0 0
EIF3A 0.025 0.02 -10000 0 -0.44 1 1
RPS6KB1 -0.004 0.087 0.24 3 -0.34 23 26
MAP3K5 0.002 0.036 0.19 3 -0.2 13 16
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
apoptosis 0.003 0.035 0.19 3 -0.2 13 16
mol:LY294002 0 0 0.001 2 -0.001 11 13
EIF4B -0.004 0.08 0.28 4 -0.3 22 26
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 0.015 0.08 0.24 2 -0.29 22 24
eIF4E/eIF4G1/eIF4A1 -0.001 0.073 -10000 0 -0.27 36 36
KIAA1303 0 0 -10000 0 -10000 0 0
PI3K 0.029 0.052 -10000 0 -0.26 15 15
mTOR/RHEB/GTP/Raptor/GBL 0.003 0.035 0.19 8 -0.18 2 10
FKBP1A 0.021 0.011 -10000 0 -10000 0 0
RHEB/GTP 0.025 0.05 0.2 1 -0.28 4 5
mol:Amino Acids 0 0 0.001 2 -0.001 11 13
FKBP12/Rapamycin 0.016 0.008 -10000 0 -10000 0 0
PDPK1 -0.015 0.039 0.16 3 -0.25 12 15
EIF4E 0.024 0.028 -10000 0 -0.44 2 2
ASK1/PP5C -0.002 0.14 -10000 0 -0.45 42 42
mTOR/RHEB/GTP/Raptor/GBL/eIF4E 0.007 0.051 -10000 0 -0.29 7 7
TSC1/TSC2 0.022 0.06 0.21 3 -0.26 10 13
tumor necrosis factor receptor activity 0 0 0.001 11 -0.001 2 13
RPS6 0.026 0.008 -10000 0 -10000 0 0
PPP5C 0.026 0.004 -10000 0 -10000 0 0
EIF4G1 0.027 0.002 -10000 0 -10000 0 0
IRS1 0 0.046 -10000 0 -0.32 11 11
INS -0.017 0.009 -10000 0 -10000 0 0
PTEN 0.025 0.006 -10000 0 -10000 0 0
PDK2 -0.015 0.041 0.16 3 -0.24 14 17
EIF4EBP1 -0.072 0.3 -10000 0 -1 50 50
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
PPP2R5D -0.014 0.11 0.25 3 -0.4 37 40
peptide biosynthetic process -0.009 0.04 0.18 21 -0.25 2 23
RHEB 0.026 0.006 -10000 0 -10000 0 0
EIF4A1 0.022 0.01 -10000 0 -10000 0 0
mol:Rapamycin 0 0.001 0.003 9 -0.003 10 19
EEF2 -0.009 0.04 0.18 21 -0.25 2 23
eIF4E/4E-BP1 -0.056 0.29 -10000 0 -0.97 50 50
Nectin adhesion pathway

Figure S88.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S88.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB 0.02 0.056 -10000 0 -0.44 8 8
alphaV beta3 Integrin 0.025 0.072 -10000 0 -0.33 21 21
PTK2 -0.003 0.098 -10000 0 -0.42 20 20
positive regulation of JNK cascade 0.015 0.083 -10000 0 -0.31 17 17
CDC42/GDP 0.036 0.12 0.3 1 -0.4 25 26
Rac1/GDP 0.03 0.12 -10000 0 -0.4 24 24
RAP1B 0.027 0.002 -10000 0 -10000 0 0
RAP1A 0.025 0.02 -10000 0 -0.44 1 1
CTNNB1 0.026 0.003 -10000 0 -10000 0 0
CDC42/GTP 0.029 0.1 -10000 0 -0.39 17 17
nectin-3/I-afadin 0.023 0.073 -10000 0 -0.32 24 24
RAPGEF1 0.008 0.11 -10000 0 -0.42 25 25
mol:GTP 0 0 -10000 0 -10000 0 0
CRK -0.009 0.11 -10000 0 -0.47 25 25
PDGFB-D/PDGFRB 0.02 0.056 -10000 0 -0.44 8 8
TLN1 -0.012 0.045 -10000 0 -0.38 5 5
Rap1/GTP 0.013 0.082 -10000 0 -0.31 23 23
IQGAP1 0.024 0.029 -10000 0 -0.44 2 2
Rap1/GTP/I-afadin 0.047 0.022 -10000 0 -0.25 2 2
nectin-3(dimer)/I-afadin/I-afadin/nectin-3(dimer)/I-afadin/I-afadin 0.023 0.073 -10000 0 -0.32 24 24
PVR 0.026 0.003 -10000 0 -10000 0 0
Necl-5(dimer) 0.026 0.003 -10000 0 -10000 0 0
mol:GDP 0.025 0.14 0.31 1 -0.5 24 25
MLLT4 0.025 0.02 -10000 0 -0.44 1 1
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
PI3K 0.055 0.08 -10000 0 -0.25 34 34
nectin-1(dimer)/I-afadin/I-afadin/nectin-1(dimer)/I-afadin/I-afadin 0.036 0.027 -10000 0 -0.32 3 3
positive regulation of lamellipodium assembly 0.01 0.1 -10000 0 -0.32 26 26
PVRL1 0.024 0.028 -10000 0 -0.44 2 2
PVRL3 0.007 0.093 -10000 0 -0.44 23 23
PVRL2 0.026 0.02 -10000 0 -0.44 1 1
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
CDH1 0.026 0.02 -10000 0 -0.44 1 1
CLDN1 0.011 0.085 -10000 0 -0.44 19 19
JAM-A/CLDN1 0.042 0.084 -10000 0 -0.25 41 41
SRC -0.009 0.12 -10000 0 -0.51 25 25
ITGB3 0.018 0.066 -10000 0 -0.44 11 11
nectin-1(dimer)/I-afadin/I-afadin 0.036 0.027 -10000 0 -0.32 3 3
FARP2 0.031 0.13 -10000 0 -0.51 17 17
RAC1 0.024 0.008 -10000 0 -10000 0 0
CTNNA1 0.025 0.028 -10000 0 -0.44 2 2
nectin-3(dimer)/I-afadin/I-afadin/Necl-5(dimer) 0.038 0.065 -10000 0 -0.27 23 23
nectin-1/I-afadin 0.036 0.027 -10000 0 -0.32 3 3
nectin-2/I-afadin 0.037 0.023 -10000 0 -0.32 2 2
RAC1/GTP/IQGAP1/filamentous actin 0.03 0.022 -10000 0 -0.27 2 2
nectin-1(dimer)/I-afadin/I-afadin/nectin-3(dimer/I-afadin/I-afadin 0.036 0.069 -10000 0 -0.27 26 26
CDC42/GTP/IQGAP1/filamentous actin 0.029 0.038 -10000 0 -0.38 4 4
F11R 0.026 0.004 -10000 0 -10000 0 0
positive regulation of filopodium formation 0.015 0.083 -10000 0 -0.31 17 17
alphaV/beta3 Integrin/Talin -0.01 0.093 -10000 0 -0.3 24 24
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.037 0.023 -10000 0 -0.32 2 2
nectin-2(dimer)/I-afadin/I-afadin 0.037 0.023 -10000 0 -0.32 2 2
PIP5K1C -0.005 0.046 -10000 0 -0.2 23 23
VAV2 0.014 0.16 -10000 0 -0.5 34 34
RAP1/GDP 0.039 0.11 0.27 2 -0.38 23 25
ITGAV 0.017 0.065 -10000 0 -0.44 11 11
nectin-3(dimer)/I-afadin/I-afadin/nectin-2(dimer)/I-afadin/I-afadin 0.038 0.067 -10000 0 -0.27 24 24
nectin-3(dimer)/I-afadin/I-afadin 0.023 0.073 -10000 0 -0.32 24 24
Rac1/GTP 0.015 0.12 -10000 0 -0.4 26 26
PTPRM 0 0.051 -10000 0 -0.22 24 24
E-cadherin/beta catenin/alpha catenin 0.07 0.042 -10000 0 -0.27 6 6
adherens junction assembly 0 0 -10000 0 -10000 0 0
CDC42 0.022 0.04 -10000 0 -0.44 4 4
S1P5 pathway

Figure S89.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S89.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:S1P 0 0 -10000 0 -10000 0 0
telencephalon oligodendrocyte cell migration -0.009 0.084 0.27 27 -10000 0 27
GNAI2 0.026 0.004 -10000 0 -10000 0 0
S1P/S1P5/G12 0.029 0.036 -10000 0 -0.27 7 7
mol:GDP 0 0 -10000 0 -10000 0 0
GNAO1 0.018 0.084 -10000 0 -0.44 17 17
RhoA/GTP 0.01 0.086 -10000 0 -0.28 27 27
negative regulation of cAMP metabolic process -0.003 0.087 -10000 0 -0.25 47 47
GNAZ 0.015 0.071 -10000 0 -0.44 13 13
GNAI3 0.026 0.005 -10000 0 -10000 0 0
GNA12 0.024 0.008 -10000 0 -10000 0 0
S1PR5 0.021 0.053 -10000 0 -0.44 7 7
mol:GTP 0 0 -10000 0 -10000 0 0
S1P/S1P5/Gi -0.002 0.087 -10000 0 -0.25 47 47
RhoA/GDP 0.019 0.014 -10000 0 -0.32 1 1
RHOA 0.025 0.02 -10000 0 -0.44 1 1
GNAI1 0.018 0.063 -10000 0 -0.44 10 10
Paxillin-dependent events mediated by a4b1

Figure S90.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S90.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CRKL 0.026 0.005 -10000 0 -10000 0 0
Rac1/GDP 0.026 0.012 -10000 0 -10000 0 0
DOCK1 0.025 0.02 -10000 0 -0.44 1 1
ITGA4 0.006 0.097 -10000 0 -0.44 25 25
RAC1 0.024 0.008 -10000 0 -10000 0 0
alpha4/beta7 Integrin 0.014 0.1 -10000 0 -0.35 38 38
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.022 0.011 -10000 0 -10000 0 0
alpha4/beta1 Integrin 0.039 0.068 -10000 0 -0.27 25 25
alpha4/beta7 Integrin/Paxillin 0.022 0.084 -10000 0 -0.28 38 38
lamellipodium assembly -0.003 0.095 -10000 0 -0.42 22 22
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
PI3K 0.035 0.031 -10000 0 -0.32 4 4
ARF6 0.024 0.021 -10000 0 -0.44 1 1
TLN1 0.025 0.02 -10000 0 -0.44 1 1
PXN -0.012 0.001 -10000 0 -10000 0 0
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
ARF6/GTP 0.039 0.059 -10000 0 -0.22 25 25
cell adhesion 0.041 0.062 -10000 0 -0.24 26 26
CRKL/CBL 0.037 0.009 -10000 0 -10000 0 0
alpha4/beta1 Integrin/Paxillin 0.03 0.061 -10000 0 -0.25 25 25
ITGB1 0.027 0.002 -10000 0 -10000 0 0
ITGB7 0.013 0.084 -10000 0 -0.44 18 18
ARF6/GDP 0.026 0.023 -10000 0 -0.44 1 1
alpha4/beta1 Integrin/Paxillin/VCAM1 0.036 0.09 -10000 0 -0.31 32 32
p130Cas/Crk/Dock1 0.042 0.032 -10000 0 -0.28 3 3
VCAM1 0.012 0.084 -10000 0 -0.44 18 18
alpha4/beta1 Integrin/Paxillin/Talin 0.043 0.063 -10000 0 -0.24 26 26
alpha4/beta1 Integrin/Paxillin/GIT1 0.043 0.061 -10000 0 -0.24 24 24
BCAR1 0.025 0.029 -10000 0 -0.44 2 2
mol:GDP -0.041 0.06 0.24 24 -10000 0 24
CBL 0.026 0.004 -10000 0 -10000 0 0
PRKACA 0.026 0.003 -10000 0 -10000 0 0
GIT1 0.025 0.02 -10000 0 -0.44 1 1
alpha4/beta1 Integrin/Paxillin/Talin/Actin Cytoskeleton 0.043 0.063 -10000 0 -0.24 26 26
Rac1/GTP -0.005 0.1 -10000 0 -0.47 22 22
IL2 signaling events mediated by PI3K

Figure S91.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S91.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.059 0.12 -10000 0 -0.49 5 5
UGCG 0.009 0.081 -10000 0 -0.7 6 6
AKT1/mTOR/p70S6K/Hsp90/TERT -0.017 0.15 0.22 1 -0.49 34 35
mol:GTP 0 0 -10000 0 -10000 0 0
mol:glucosylceramide 0.009 0.08 -10000 0 -0.69 6 6
mol:DAG -0.002 0.1 -10000 0 -0.82 8 8
CaM/Ca2+/Calcineurin A alpha-beta B1 0 0.14 -10000 0 -0.43 38 38
FRAP1 -0.011 0.16 -10000 0 -0.5 38 38
FOXO3 -0.012 0.14 0.35 1 -0.44 36 37
AKT1 -0.01 0.15 -10000 0 -0.47 36 36
GAB2 0.025 0.028 -10000 0 -0.44 2 2
SMPD1 0.007 0.09 -10000 0 -0.76 7 7
SGMS1 0.008 0.078 -10000 0 -0.61 8 8
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
mol:GDP -0.009 0.022 -10000 0 -0.27 4 4
CALM1 0.025 0.007 -10000 0 -10000 0 0
cell proliferation 0.019 0.098 -10000 0 -0.46 10 10
EIF3A 0.025 0.02 -10000 0 -0.44 1 1
PI3K 0.038 0.032 -10000 0 -0.32 4 4
RPS6KB1 -0.001 0.14 -10000 0 -0.86 13 13
mol:sphingomyelin -0.002 0.1 -10000 0 -0.82 8 8
natural killer cell activation 0 0.001 -10000 0 -0.01 4 4
JAK3 0.022 0.053 -10000 0 -0.44 7 7
PIK3R1 0.025 0.029 -10000 0 -0.44 2 2
JAK1 0.026 0.021 -10000 0 -0.44 1 1
NFKB1 0.025 0.02 -10000 0 -0.44 1 1
MYC 0.016 0.16 -10000 0 -0.58 19 19
MYB 0.003 0.16 -10000 0 -1.1 10 10
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K -0.007 0.13 -10000 0 -0.43 34 34
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 0.027 0.13 -10000 0 -0.8 13 13
mol:PI-3-4-5-P3 -0.006 0.13 -10000 0 -0.42 34 34
Rac1/GDP 0.017 0.025 -10000 0 -0.25 4 4
T cell proliferation -0.008 0.12 0.22 1 -0.41 30 31
SHC1 0.026 0.005 -10000 0 -10000 0 0
RAC1 0.024 0.008 -10000 0 -10000 0 0
positive regulation of cyclin-dependent protein kinase activity 0.002 0.009 -10000 0 -0.065 9 9
PRKCZ -0.01 0.12 0.23 1 -0.42 31 32
NF kappa B1 p50/RelA 0.01 0.15 -10000 0 -0.45 35 35
IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K 0.003 0.095 -10000 0 -0.42 19 19
HSP90AA1 0.024 0.021 -10000 0 -0.44 1 1
RELA 0.026 0.004 -10000 0 -10000 0 0
IL2RA -0.007 0.12 -10000 0 -0.44 41 41
IL2RB 0.014 0.081 -10000 0 -0.44 17 17
TERT 0.007 0.1 -10000 0 -0.44 28 28
E2F1 0.004 0.066 -10000 0 -0.42 10 10
SOS1 0.027 0.004 -10000 0 -10000 0 0
RPS6 0.026 0.008 -10000 0 -10000 0 0
mol:cAMP -0.001 0.004 0.032 9 -10000 0 9
PTPN11 0.022 0.045 -10000 0 -0.45 5 5
IL2RG 0.019 0.066 -10000 0 -0.44 11 11
actin cytoskeleton organization -0.008 0.12 0.22 1 -0.41 30 31
GRB2 0.026 0.005 -10000 0 -10000 0 0
IL2 0.02 0.011 -10000 0 -10000 0 0
PIK3CA 0.026 0.028 -10000 0 -0.44 2 2
Rac1/GTP 0.043 0.032 -10000 0 -0.23 4 4
LCK 0.016 0.085 -10000 0 -0.44 18 18
BCL2 -0.013 0.17 -10000 0 -0.67 25 25
S1P3 pathway

Figure S92.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S92.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB 0.02 0.056 -10000 0 -0.44 8 8
mol:S1P 0 0.004 -10000 0 -10000 0 0
S1P1/S1P/Gi 0 0.073 -10000 0 -0.25 37 37
GNAO1 0.018 0.085 -10000 0 -0.45 17 17
S1P/S1P3/G12/G13 0.042 0.037 -10000 0 -0.25 6 6
AKT1 -0.018 0.15 -10000 0 -0.44 53 53
AKT3 -0.003 0.17 -10000 0 -1.2 11 11
mol:GTP 0 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB 0.02 0.056 -10000 0 -0.44 8 8
GNAI2 0.026 0.01 -10000 0 -10000 0 0
GNAI3 0.025 0.01 -10000 0 -10000 0 0
GNAI1 0.017 0.063 -10000 0 -0.44 10 10
mol:GDP 0 0 -10000 0 -10000 0 0
S1PR3 0.023 0.042 -10000 0 -0.45 4 4
S1PR2 0.026 0.004 -10000 0 -10000 0 0
EDG1 0 0 -10000 0 -10000 0 0
mol:Ca2+ 0 0.1 -10000 0 -0.36 26 26
MAPK3 -0.009 0.096 0.2 1 -0.4 20 21
MAPK1 -0.004 0.091 -10000 0 -0.35 23 23
JAK2 0.03 0.13 0.22 9 -0.48 17 26
CXCR4 -0.013 0.1 -10000 0 -0.41 24 24
FLT1 0.019 0.025 -10000 0 -0.46 1 1
RhoA/GDP 0.019 0.014 -10000 0 -0.32 1 1
Rac1/GDP 0.018 0.006 -10000 0 -10000 0 0
SRC -0.002 0.09 0.2 21 -0.39 15 36
S1P/S1P3/Gi 0 0.1 -10000 0 -0.36 26 26
RAC1 0.024 0.008 -10000 0 -10000 0 0
RhoA/GTP 0.011 0.098 -10000 0 -0.38 19 19
VEGFA 0.026 0.011 -10000 0 -10000 0 0
S1P/S1P2/Gi 0.002 0.083 -10000 0 -0.26 39 39
VEGFR1 homodimer/VEGFA homodimer 0.03 0.028 -10000 0 -0.35 1 1
RHOA 0.025 0.02 -10000 0 -0.44 1 1
S1P/S1P3/Gq 0.004 0.083 -10000 0 -0.29 34 34
GNAQ 0.022 0.044 -10000 0 -0.44 5 5
GNAZ 0.015 0.072 -10000 0 -0.44 13 13
G12/G13 0.034 0.025 -10000 0 -0.32 2 2
GNA14 0.014 0.076 -10000 0 -0.44 15 15
GNA15 0.015 0.074 -10000 0 -0.44 14 14
GNA12 0.024 0.008 -10000 0 -10000 0 0
GNA13 0.024 0.028 -10000 0 -0.44 2 2
GNA11 0.024 0.035 -10000 0 -0.44 3 3
Rac1/GTP 0.007 0.096 -10000 0 -0.39 18 18
PLK1 signaling events

Figure S93.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S93.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
regulation of centriole-centriole cohesion -0.008 0.029 0.15 14 -0.11 2 16
BUB1B 0.014 0.044 0.12 3 -0.18 9 12
PLK1 0.022 0.028 0.097 6 -0.1 3 9
PLK1S1 0.02 0.051 0.13 6 -0.18 22 28
KIF2A 0.016 0.027 0.18 2 -10000 0 2
regulation of mitotic centrosome separation 0.022 0.028 0.097 6 -0.1 3 9
GOLGA2 0.025 0.028 -10000 0 -0.44 2 2
Hec1/SPC24 0.032 0.054 -10000 0 -0.2 20 20
WEE1 0.024 0.057 -10000 0 -0.37 8 8
cytokinesis 0.017 0.056 -10000 0 -0.34 6 6
PP2A-alpha B56 0.049 0.095 -10000 0 -0.53 14 14
AURKA 0.023 0.022 0.1 1 -10000 0 1
PICH/PLK1 0.011 0.044 0.15 4 -0.24 12 16
CENPE 0.008 0.049 0.11 1 -0.22 18 19
RhoA/GTP 0.019 0.014 -10000 0 -0.32 1 1
positive regulation of microtubule depolymerization 0.016 0.027 0.18 2 -10000 0 2
PPP2CA 0.026 0.004 -10000 0 -10000 0 0
FZR1 0.025 0.02 -10000 0 -0.44 1 1
TPX2 0.036 0.041 0.12 5 -0.25 2 7
PAK1 0.027 0.004 -10000 0 -10000 0 0
SPC24 0.018 0.065 -10000 0 -0.44 11 11
FBXW11 0.026 0.004 -10000 0 -10000 0 0
CLSPN 0.014 0.044 -10000 0 -0.22 16 16
GORASP1 0.026 0.003 -10000 0 -10000 0 0
metaphase 0.001 0.002 0.017 8 -0.012 2 10
mol:GTP 0 0 -10000 0 -10000 0 0
NLP 0.011 0.016 0.037 70 -0.049 5 75
G2 phase of mitotic cell cycle 0.001 0.003 0.014 11 -10000 0 11
STAG2 0.023 0.04 -10000 0 -0.44 4 4
GRASP65/GM130/RAB1/GTP 0.012 0.048 -10000 0 -0.46 5 5
spindle elongation 0.022 0.028 0.097 6 -0.1 3 9
ODF2 0.029 0.004 -10000 0 -10000 0 0
BUB1 0.014 0.093 -10000 0 -0.58 13 13
TPT1 0.025 0.038 0.098 28 -0.17 9 37
CDC25C 0.017 0.041 -10000 0 -0.25 11 11
CDC25B 0.021 0.013 -10000 0 -10000 0 0
SGOL1 0.008 0.029 0.11 2 -0.15 14 16
RHOA 0.025 0.02 -10000 0 -0.44 1 1
CCNB1/CDK1 0.032 0.034 -10000 0 -0.21 3 3
CDC14B -0.001 0.024 -10000 0 -0.32 3 3
CDC20 0.026 0.003 -10000 0 -10000 0 0
PLK1/PBIP1 0.012 0.037 0.089 3 -0.2 11 14
mitosis -0.001 0.002 -10000 0 -10000 0 0
FBXO5 0.013 0.037 0.16 4 -0.19 6 10
CDC2 0.002 0.002 0.009 1 -0.01 2 3
NDC80 0.014 0.059 -10000 0 -0.44 9 9
metaphase plate congression 0.006 0.065 -10000 0 -0.22 39 39
ERCC6L 0.011 0.048 0.16 1 -0.24 13 14
NLP/gamma Tubulin 0.011 0.017 0.076 7 -0.07 5 12
microtubule cytoskeleton organization 0.025 0.038 0.098 28 -0.17 9 37
G2/M transition DNA damage checkpoint 0 0.002 0.013 10 -10000 0 10
PPP1R12A 0.025 0.035 -10000 0 -0.45 3 3
interphase 0 0.002 0.013 10 -10000 0 10
PLK1/PRC1-2 0.046 0.033 -10000 0 -0.2 2 2
GRASP65/GM130/RAB1/GTP/PLK1 0.057 0.03 -10000 0 -0.2 2 2
RAB1A 0.026 0.02 -10000 0 -0.44 1 1
prophase 0 0 -10000 0 -10000 0 0
Aurora A/BORA 0.026 0.031 0.074 72 -10000 0 72
mitotic prometaphase 0.001 0.005 0.018 39 -10000 0 39
proteasomal ubiquitin-dependent protein catabolic process 0.022 0.033 0.17 1 -0.22 1 2
microtubule-based process 0.034 0.03 0.12 1 -0.21 2 3
Golgi organization 0.022 0.028 0.097 6 -0.1 3 9
Cohesin/SA2 0.032 0.029 0.11 1 -0.2 4 5
PPP1CB/MYPT1 0.037 0.04 -10000 0 -0.37 5 5
KIF20A 0.025 0.028 -10000 0 -0.44 2 2
APC/C/CDC20 0.036 0.026 0.12 1 -10000 0 1
PPP2R1A 0.025 0.02 -10000 0 -0.44 1 1
chromosome segregation 0.011 0.036 0.088 3 -0.2 11 14
PRC1 0.026 0.005 -10000 0 -10000 0 0
ECT2 0.011 0.047 0.21 4 -0.22 13 17
C13orf34 0.021 0.026 0.063 70 -0.074 3 73
NUDC 0.006 0.065 -10000 0 -0.22 39 39
regulation of attachment of spindle microtubules to kinetochore 0.014 0.044 0.12 3 -0.17 9 12
spindle assembly 0.017 0.024 0.092 12 -0.089 3 15
spindle stabilization 0.02 0.051 0.13 6 -0.18 22 28
APC/C/HCDH1 0.022 0.025 -10000 0 -0.27 4 4
MKLP2/PLK1 0.034 0.03 0.12 1 -0.21 2 3
CCNB1 0.025 0.011 -10000 0 -10000 0 0
PPP1CB 0.025 0.035 -10000 0 -0.45 3 3
BTRC 0.025 0.021 -10000 0 -0.44 1 1
ROCK2 0.016 0.068 -10000 0 -0.4 12 12
TUBG1 0.017 0.023 0.11 2 -0.17 4 6
G2/M transition of mitotic cell cycle 0.007 0.028 0.17 1 -0.21 3 4
MLF1IP -0.007 0.045 -10000 0 -0.32 11 11
INCENP 0.027 0.004 -10000 0 -10000 0 0
Signaling mediated by p38-gamma and p38-delta

Figure S94.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S94.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EEF2K -0.012 0.012 -10000 0 -0.27 1 1
SNTA1 0.013 0.036 -10000 0 -0.44 3 3
response to hypoxia 0 0 -10000 0 -10000 0 0
STMN1 -0.016 0.039 -10000 0 -0.3 10 10
MAPK12 -0.011 0.054 0.2 9 -0.25 21 30
CCND1 0.002 0.048 -10000 0 -0.36 7 7
p38 gamma/SNTA1 0.001 0.052 0.19 5 -0.24 19 24
MAP2K3 0.022 0.01 -10000 0 -10000 0 0
PKN1 0.024 0.034 -10000 0 -0.44 3 3
G2/M transition checkpoint -0.011 0.054 0.2 9 -0.25 21 30
MAP2K6 -0.004 0.046 -10000 0 -0.26 18 18
MAPT -0.021 0.085 0.25 6 -0.3 37 43
MAPK13 -0.01 0.014 -10000 0 -0.32 1 1
hyperosmotic response 0 0 -10000 0 -10000 0 0
ZAK 0.008 0.037 -10000 0 -0.3 8 8
Arf6 trafficking events

Figure S95.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S95.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SLC2A4 0.016 0.064 -10000 0 -0.44 10 10
CLTC -0.006 0.11 0.22 1 -0.4 35 36
calcium ion-dependent exocytosis 0.006 0.053 -10000 0 -0.18 30 30
Dynamin 2/GTP 0.022 0.018 -10000 0 -0.25 2 2
EXOC4 0.026 0.005 -10000 0 -10000 0 0
CD59 -0.005 0.086 -10000 0 -0.35 31 31
CPE -0.018 0.079 -10000 0 -0.27 49 49
CTNNB1 0.026 0.003 -10000 0 -10000 0 0
membrane fusion 0.014 0.031 -10000 0 -0.37 1 1
CTNND1 -0.012 0.027 0.18 8 -0.23 2 10
DNM2 0.026 0.02 -10000 0 -0.44 1 1
mol:PI-4-5-P2 -0.001 0.067 -10000 0 -0.26 25 25
TSHR 0 0.026 -10000 0 -0.28 3 3
INS 0.004 0.051 -10000 0 -0.49 5 5
BIN1 0.022 0.044 -10000 0 -0.44 5 5
mol:Choline 0.014 0.031 -10000 0 -0.37 1 1
growth hormone secretagogue receptor activity 0 0 -10000 0 -10000 0 0
mol:GDP 0.011 0.012 -10000 0 -0.27 1 1
membrane depolarization 0 0 -10000 0 -10000 0 0
ARF6 0.024 0.021 -10000 0 -0.44 1 1
mol:Ca2+ 0.022 0.018 -10000 0 -0.24 2 2
JUP -0.005 0.086 -10000 0 -0.33 33 33
ASAP2/amphiphysin II 0.043 0.037 -10000 0 -0.25 8 8
ARF6/GTP 0.018 0.015 -10000 0 -0.32 1 1
CDH1 -0.006 0.086 -10000 0 -0.34 31 31
clathrin-independent pinocytosis 0.018 0.015 -10000 0 -0.31 1 1
MAPK8IP3 0.024 0.035 -10000 0 -0.44 3 3
positive regulation of endocytosis 0.018 0.015 -10000 0 -0.31 1 1
EXOC2 0.025 0.02 -10000 0 -0.44 1 1
substrate adhesion-dependent cell spreading 0.004 0.072 -10000 0 -0.39 9 9
insulin receptor binding 0 0 -10000 0 -10000 0 0
SPAG9 0.025 0.02 -10000 0 -0.44 1 1
regulation of calcium-dependent cell-cell adhesion -0.016 0.093 0.32 34 -10000 0 34
positive regulation of phagocytosis 0.01 0.012 -10000 0 -0.27 1 1
ARF6/GTP/JIP3 0.031 0.028 -10000 0 -0.27 4 4
ACAP1 0.013 0.038 -10000 0 -0.17 10 10
mol:GTP 0 0 -10000 0 -10000 0 0
CHRM2 -0.018 0.096 0.18 3 -0.35 32 35
clathrin heavy chain/ACAP1 -0.002 0.092 0.21 5 -0.34 32 37
JIP4/KLC1 0.045 0.023 -10000 0 -0.25 2 2
EXOC1 0.025 0.02 -10000 0 -0.44 1 1
exocyst 0.001 0.071 -10000 0 -0.4 9 9
RALA/GTP 0.018 0.006 -10000 0 -10000 0 0
ARF6/GTP/ARF6/GTP/JIP4/Dynactin Complex 0.032 0.021 -10000 0 -0.27 2 2
receptor recycling 0.018 0.015 -10000 0 -0.31 1 1
CTNNA1 -0.012 0.03 0.18 8 -0.23 4 12
NME1 0.011 0.012 -10000 0 -0.27 1 1
clathrin coat assembly -0.006 0.11 0.22 1 -0.39 36 37
IL2RA -0.017 0.1 -10000 0 -0.36 33 33
VAMP3 0.01 0.012 -10000 0 -0.27 1 1
GLUT4/clathrin heavy chain/ACAP1 0.004 0.095 0.2 1 -0.31 33 34
EXOC6 0.023 0.035 -10000 0 -0.44 3 3
PLD1 0.008 0.023 -10000 0 -0.47 1 1
PLD2 0.009 0.01 -10000 0 -0.14 1 1
EXOC5 0.013 0.073 -10000 0 -0.44 14 14
PIP5K1C 0.003 0.058 -10000 0 -0.22 28 28
SDC1 -0.005 0.086 -10000 0 -0.33 33 33
ARF6/GDP 0.021 0.014 -10000 0 -0.27 1 1
EXOC7 0.026 0.004 -10000 0 -10000 0 0
E-cadherin/beta catenin 0.018 0.096 -10000 0 -0.33 34 34
mol:Phosphatidic acid 0.014 0.031 -10000 0 -0.37 1 1
endocytosis -0.042 0.037 0.24 8 -10000 0 8
SCAMP2 0.025 0.006 -10000 0 -10000 0 0
ADRB2 -0.02 0.11 0.38 1 -0.38 39 40
EXOC3 0.026 0.004 -10000 0 -10000 0 0
ASAP2 0.025 0.028 -10000 0 -0.44 2 2
Dynamin 2/GDP 0.025 0.018 -10000 0 -0.25 2 2
KLC1 0.025 0.007 -10000 0 -10000 0 0
AVPR2 -0.018 0.11 0.27 6 -0.38 37 43
RALA 0.024 0.008 -10000 0 -10000 0 0
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.01 0.091 -10000 0 -0.32 32 32
Regulation of Telomerase

Figure S96.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S96.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Telomerase catalytic core complex -0.054 0.27 0.39 1 -1.1 32 33
RAD9A 0.025 0.02 -10000 0 -0.44 1 1
AP1 0.022 0.071 -10000 0 -0.32 21 21
IFNAR2 0.022 0.025 -10000 0 -0.44 1 1
AKT1 0.002 0.05 -10000 0 -0.2 28 28
ER alpha/Oestrogen 0.003 0.073 -10000 0 -0.32 27 27
NFX1/SIN3/HDAC complex 0.029 0.055 0.18 1 -0.28 4 5
EGF -0.031 0.17 -10000 0 -0.44 80 80
SMG5 0.025 0.02 -10000 0 -0.44 1 1
SMG6 0.022 0.01 -10000 0 -10000 0 0
SP3/HDAC2 0.035 0.026 -10000 0 -0.32 1 1
TERT/c-Abl -0.045 0.26 -10000 0 -0.98 34 34
SAP18 0.021 0.011 -10000 0 -10000 0 0
MRN complex 0.032 0.076 -10000 0 -0.35 18 18
WT1 -0.057 0.19 -10000 0 -0.44 110 110
WRN 0.019 0.03 -10000 0 -0.44 2 2
SP1 0.023 0.026 -10000 0 -0.44 1 1
SP3 0.023 0.023 -10000 0 -0.44 1 1
TERF2IP 0.026 0.02 -10000 0 -0.44 1 1
Telomerase/Nucleolin -0.028 0.24 -10000 0 -0.88 34 34
Mad/Max 0.034 0.025 -10000 0 -0.32 1 1
TERT -0.058 0.29 0.39 1 -1.2 32 33
CCND1 -0.047 0.24 -10000 0 -0.95 32 32
MAX 0.023 0.013 -10000 0 -10000 0 0
RBBP7 0.025 0.02 -10000 0 -0.44 1 1
RBBP4 0.025 0.02 -10000 0 -0.44 1 1
TERF2 0.025 0.012 -10000 0 -10000 0 0
PTGES3 0.025 0.028 -10000 0 -0.44 2 2
SIN3A 0.024 0.021 -10000 0 -0.44 1 1
Telomerase/911 0.031 0.056 -10000 0 -0.42 3 3
CDKN1B -0.009 0.074 -10000 0 -0.27 37 37
RAD1 0.026 0.004 -10000 0 -10000 0 0
XRCC5 0.026 0.02 -10000 0 -0.44 1 1
XRCC6 0.025 0.006 -10000 0 -10000 0 0
SAP30 0.023 0.029 -10000 0 -0.44 2 2
TRF2/PARP2 0.035 0.018 -10000 0 -0.28 1 1
UBE3A 0.02 0.036 -10000 0 -0.44 3 3
JUN 0.021 0.041 -10000 0 -0.44 4 4
E6 0 0.003 -10000 0 -10000 0 0
HPV-16 E6/E6AP 0.015 0.027 -10000 0 -0.32 3 3
FOS 0.011 0.083 -10000 0 -0.43 18 18
IFN-gamma/IRF1 0.019 0.093 -10000 0 -0.31 38 38
PARP2 0.024 0.021 -10000 0 -0.44 1 1
BLM 0.021 0.044 -10000 0 -0.44 5 5
Telomerase -0.008 0.11 -10000 0 -0.45 20 20
IRF1 0.027 0.015 -10000 0 -0.17 1 1
ESR1 0.004 0.1 -10000 0 -0.44 27 27
KU/TER 0.037 0.017 -10000 0 -0.32 1 1
ATM/TRF2 0.033 0.04 -10000 0 -0.26 9 9
ubiquitin-dependent protein catabolic process 0.024 0.064 -10000 0 -0.26 10 10
HPV-16 E6/E6AP/NFX1/SIN3/HDAC complex 0.024 0.065 -10000 0 -0.26 10 10
HDAC1 0.026 0.005 -10000 0 -10000 0 0
HDAC2 0.023 0.017 -10000 0 -10000 0 0
ATM 0.005 0.044 -10000 0 -0.36 8 8
SMAD3 -0.015 0.04 -10000 0 -0.32 9 9
ABL1 0.026 0.02 -10000 0 -0.44 1 1
MXD1 0.024 0.024 -10000 0 -0.44 1 1
MRE11A 0.019 0.056 -10000 0 -0.44 8 8
HUS1 0.024 0.008 -10000 0 -10000 0 0
RPS6KB1 0.021 0.044 -10000 0 -0.44 5 5
TERT/NF kappa B1/14-3-3 -0.038 0.26 0.39 1 -0.95 34 35
NR2F2 0.026 0.009 -10000 0 -10000 0 0
MAPK3 -0.011 0.019 -10000 0 -0.32 1 1
MAPK1 -0.01 0.014 -10000 0 -10000 0 0
TGFB1/TGF beta receptor Type II 0.019 0.059 -10000 0 -0.44 9 9
NFKB1 0.025 0.02 -10000 0 -0.44 1 1
HNRNPC 0.025 0.007 -10000 0 -10000 0 0
DNA damage response signal transduction by p53 class mediator resulting in induction of apoptosis 0.005 0.044 -10000 0 -0.36 8 8
NBN 0.01 0.076 -10000 0 -0.44 15 15
EGFR 0.019 0.045 -10000 0 -0.44 5 5
mol:Oestrogen 0 0.002 -10000 0 -10000 0 0
EGF/EGFR -0.007 0.13 -10000 0 -0.32 75 75
MYC 0.016 0.046 -10000 0 -0.44 5 5
IL2 0.017 0.018 -10000 0 -10000 0 0
KU 0.037 0.017 -10000 0 -0.32 1 1
RAD50 0.025 0.02 -10000 0 -0.44 1 1
HSP90AA1 0.024 0.021 -10000 0 -0.44 1 1
TGFB1 0.019 0.06 -10000 0 -0.44 9 9
TRF2/BLM 0.034 0.034 -10000 0 -0.3 5 5
FRAP1 0 0 -10000 0 -10000 0 0
KU/TERT -0.034 0.26 0.37 1 -1 33 34
SP1/HDAC2 0.035 0.029 -10000 0 -0.32 1 1
PINX1 0.016 0.045 -10000 0 -0.44 5 5
Telomerase/EST1A -0.032 0.23 -10000 0 -0.88 34 34
Smad3/Myc 0.013 0.049 -10000 0 -0.27 15 15
911 complex 0.047 0.023 -10000 0 -0.27 1 1
IFNG -0.001 0.12 -10000 0 -0.43 38 38
Telomerase/PinX1 -0.039 0.23 -10000 0 -0.87 35 35
Telomerase/AKT1/mTOR/p70S6K -0.012 0.11 0.28 1 -0.46 16 17
SIN3B 0.025 0.02 -10000 0 -0.44 1 1
YWHAE 0.022 0.01 -10000 0 -10000 0 0
Telomerase/EST1B -0.028 0.24 -10000 0 -0.87 35 35
response to DNA damage stimulus 0 0.023 -10000 0 -0.11 24 24
MRN complex/TRF2/Rap1 0.05 0.073 -10000 0 -0.3 18 18
TRF2/WRN 0.029 0.026 -10000 0 -0.29 2 2
Telomerase/hnRNP C1/C2 -0.027 0.24 -10000 0 -0.88 34 34
E2F1 0.013 0.025 -10000 0 -0.44 1 1
ZNFX1 0.015 0.013 -10000 0 -10000 0 0
PIF1 0.022 0.04 -10000 0 -0.44 4 4
NCL 0.027 0.002 -10000 0 -10000 0 0
DKC1 0.026 0.003 -10000 0 -10000 0 0
telomeric DNA binding 0 0 -10000 0 -10000 0 0
Insulin Pathway

Figure S97.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S97.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CBL/APS/CAP 0.041 0.07 -10000 0 -0.24 27 27
TC10/GTP 0.029 0.056 -10000 0 -0.22 23 23
Insulin Receptor/Insulin/IRS1/Shp2 0.066 0.058 -10000 0 -0.24 15 15
HRAS 0.026 0.021 -10000 0 -0.44 1 1
APS homodimer 0.017 0.069 -10000 0 -0.44 12 12
GRB14 -0.049 0.18 -10000 0 -0.44 92 92
FOXO3 -0.001 0.12 -10000 0 -0.65 17 17
AKT1 -0.037 0.09 0.2 6 -10000 0 6
INSR 0.037 0.024 -10000 0 -0.42 1 1
Insulin Receptor/Insulin 0.073 0.072 0.25 1 -10000 0 1
mol:GTP 0 0 -10000 0 -10000 0 0
GRB10 0.021 0.04 -10000 0 -0.44 4 4
SORBS1 0.018 0.067 -10000 0 -0.44 11 11
CRK 0.022 0.011 -10000 0 -10000 0 0
PTPN1 -0.001 0.029 0.3 1 -10000 0 1
CAV1 0.007 0.057 0.17 23 -0.22 13 36
CBL/APS/CAP/Crk-II/C3G 0.05 0.069 -10000 0 -0.23 23 23
Insulin Receptor/Insulin/IRS1/NCK2 0.069 0.052 -10000 0 -0.24 11 11
mol:GDP 0 0 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 0.05 0.048 -10000 0 -0.21 14 14
Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B 0.056 0.076 -10000 0 -0.34 6 6
RPS6KB1 -0.044 0.083 0.2 4 -0.31 2 6
PARD6A 0.026 0.021 -10000 0 -0.44 1 1
CBL 0.026 0.004 -10000 0 -10000 0 0
tumor necrosis factor-mediated signaling pathway 0 0 -10000 0 -10000 0 0
DOK1 0.019 0.01 -10000 0 -10000 0 0
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
Insulin Receptor/Insuli/IRS1/GRB2/Shc -0.014 0.096 0.18 2 -0.29 2 4
HRAS/GTP -0.016 0.057 -10000 0 -0.24 16 16
Insulin Receptor 0.037 0.024 -10000 0 -0.42 1 1
Insulin Receptor/Insuli/IRS1/GRB2/SHC 0.076 0.052 -10000 0 -0.23 10 10
PRKCI 0.011 0.074 -10000 0 -0.47 8 8
Insulin Receptor/Insulin/GRB14/PDK1 -0.014 0.097 -10000 0 -0.22 86 86
SHC1 0.026 0.004 -10000 0 -10000 0 0
negative regulation of MAPKKK cascade 0.039 0.037 -10000 0 -0.36 1 1
PI3K 0.062 0.053 -10000 0 -0.22 14 14
NCK2 0.026 0.02 -10000 0 -0.44 1 1
RHOQ 0.027 0.002 -10000 0 -10000 0 0
mol:H2O2 0.001 0.005 -10000 0 -10000 0 0
HRAS/GDP 0.019 0.015 -10000 0 -0.32 1 1
AKT2 -0.037 0.09 0.19 6 -0.23 1 7
PRKCZ 0.001 0.091 -10000 0 -0.39 18 18
SH2B2 0.017 0.069 -10000 0 -0.44 12 12
SHC/SHIP 0.027 0.071 0.19 12 -0.22 33 45
F2RL2 -0.004 0.12 -10000 0 -0.44 37 37
TRIP10 0.025 0.02 -10000 0 -0.44 1 1
Insulin Receptor/Insulin/Shc 0.057 0.028 -10000 0 -0.2 1 1
TC10/GTP/CIP4/Exocyst 0.035 0.014 -10000 0 -0.27 1 1
Insulin Receptor/Insulin/SHC/GRB2/Sos1 0.081 0.035 -10000 0 -0.19 1 1
RAPGEF1 0.026 0.02 -10000 0 -0.44 1 1
RASA1 0.024 0.028 -10000 0 -0.44 2 2
NCK1 0.025 0.028 -10000 0 -0.44 2 2
CBL/APS/CAP/Crk-II 0.042 0.066 -10000 0 -0.24 22 22
TC10/GDP 0.02 0.002 -10000 0 -10000 0 0
Insulin Receptor/Insulin/SHC/GRB10 0.063 0.044 -10000 0 -0.23 5 5
INPP5D 0.001 0.074 0.17 24 -0.23 33 57
SOS1 0.027 0.002 -10000 0 -10000 0 0
SGK1 -0.005 0.11 -10000 0 -0.7 14 14
mol:cAMP 0 0 -10000 0 -10000 0 0
PTPN11 0.022 0.044 -10000 0 -0.44 5 5
IRS1 0.019 0.059 -10000 0 -0.44 9 9
p62DOK/RasGAP 0.039 0.037 -10000 0 -0.37 1 1
INS 0.028 0.017 -10000 0 -10000 0 0
mol:PI-3-4-P2 0.001 0.073 0.17 24 -0.23 33 57
GRB2 0.026 0.004 -10000 0 -10000 0 0
EIF4EBP1 -0.038 0.08 0.18 4 -0.32 2 6
PTPRA 0.027 0.016 -10000 0 -10000 0 0
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
TC10/GTP/CIP4 0.035 0.014 -10000 0 -0.27 1 1
PDPK1 0.026 0.004 -10000 0 -10000 0 0
Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos 0.027 0.04 -10000 0 -0.22 8 8
Insulin Receptor/Insulin/IRS1 0.054 0.046 -10000 0 -0.24 10 10
Insulin Receptor/Insulin/IRS3 0.049 0.03 -10000 0 -0.28 1 1
Par3/Par6 0.04 0.077 -10000 0 -0.24 37 37
Signaling events mediated by PRL

Figure S98.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S98.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CCNE1 0.026 0.004 -10000 0 -10000 0 0
mol:Halofuginone 0.002 0.009 -10000 0 -0.21 1 1
ITGA1 0.022 0.044 -10000 0 -0.44 5 5
CDKN1A 0.003 0.056 -10000 0 -0.33 13 13
PRL-3/alpha Tubulin 0.023 0.059 -10000 0 -0.32 15 15
mol:Ca2+ -0.021 0.08 0.33 14 -0.33 19 33
AGT 0.009 0.094 -10000 0 -0.44 23 23
CCNA2 -0.007 0.045 -10000 0 -0.82 1 1
TUBA1B 0.027 0.002 -10000 0 -10000 0 0
EGR1 0.005 0.043 -10000 0 -0.32 9 9
CDK2/Cyclin E1 0.066 0.081 -10000 0 -0.3 13 13
MAPK3 -0.013 0.065 0.23 14 -0.32 16 30
PRL-2 /Rab GGTase beta 0.036 0.027 -10000 0 -0.32 3 3
MAPK1 -0.012 0.062 0.23 13 -0.32 14 27
PTP4A1 -0.006 0.048 -10000 0 -0.86 1 1
PTP4A3 0.01 0.076 -10000 0 -0.44 15 15
PTP4A2 0.026 0.005 -10000 0 -10000 0 0
ITGB1 -0.012 0.064 0.23 14 -0.32 15 29
SRC 0.015 0.023 -10000 0 -0.44 1 1
RAC1 -0.001 0.075 -10000 0 -0.41 16 16
Rab GGTase beta/Rab GGTase alpha 0.033 0.032 -10000 0 -0.32 4 4
PRL-1/ATF-5 0.076 0.096 -10000 0 -0.82 1 1
RABGGTA 0.024 0.021 -10000 0 -0.44 1 1
BCAR1 -0.01 0.054 0.34 13 -10000 0 13
RHOC -0.005 0.084 -10000 0 -0.38 23 23
RHOA -0.003 0.079 -10000 0 -0.4 19 19
cell motility 0.03 0.12 0.26 13 -0.41 22 35
PRL-1/alpha Tubulin 0.076 0.096 -10000 0 -0.82 1 1
PRL-3/alpha1 Integrin 0.021 0.066 -10000 0 -0.32 19 19
ROCK1 0.034 0.12 0.26 12 -0.42 19 31
RABGGTB 0.023 0.035 -10000 0 -0.44 3 3
CDK2 0.026 0.02 -10000 0 -0.44 1 1
mitosis -0.006 0.048 -10000 0 -0.85 1 1
ATF5 0.026 0.005 -10000 0 -10000 0 0
Class IB PI3K non-lipid kinase events

Figure S99.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S99.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
cAMP biosynthetic process -0.017 0.065 0.44 11 -10000 0 11
PI3K Class IB/PDE3B 0.017 0.065 -10000 0 -0.44 11 11
PDE3B 0.017 0.065 -10000 0 -0.44 11 11
Sphingosine 1-phosphate (S1P) pathway

Figure S100.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S100.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPHK2 0.026 0.021 -9999 0 -0.44 1 1
SPHK1 0.015 0.083 -9999 0 -0.44 17 17
GNAI2 0.026 0.004 -9999 0 -10000 0 0
mol:S1P 0.004 0.048 -9999 0 -0.26 19 19
GNAO1 0.018 0.084 -9999 0 -0.44 17 17
mol:Sphinganine-1-P -0.024 0.055 -9999 0 -0.32 18 18
growth factor activity 0 0 -9999 0 -10000 0 0
S1P/S1P2/G12/G13 0.041 0.054 -9999 0 -0.2 19 19
GNAI3 0.026 0.005 -9999 0 -10000 0 0
G12/G13 0.034 0.025 -9999 0 -0.32 2 2
S1PR3 0.023 0.04 -9999 0 -0.44 4 4
S1PR2 0.026 0.004 -9999 0 -10000 0 0
EDG1 0 0 -9999 0 -10000 0 0
S1P1/S1P -0.001 0.044 -9999 0 -0.21 21 21
S1PR5 0.021 0.053 -9999 0 -0.44 7 7
S1PR4 0.01 0.092 -9999 0 -0.44 22 22
GNAI1 0.018 0.063 -9999 0 -0.44 10 10
S1P/S1P5/G12 0.027 0.057 -9999 0 -0.21 23 23
S1P/S1P3/Gq 0.005 0.093 -9999 0 -0.36 23 23
S1P/S1P4/Gi -0.01 0.1 -9999 0 -0.31 40 40
GNAQ 0.022 0.044 -9999 0 -0.44 5 5
GNAZ 0.015 0.071 -9999 0 -0.44 13 13
GNA14 0.014 0.076 -9999 0 -0.44 15 15
GNA15 0.015 0.074 -9999 0 -0.44 14 14
GNA12 0.024 0.008 -9999 0 -10000 0 0
GNA13 0.024 0.028 -9999 0 -0.44 2 2
GNA11 0.024 0.035 -9999 0 -0.44 3 3
ABCC1 0.025 0.02 -9999 0 -0.44 1 1
Hedgehog signaling events mediated by Gli proteins

Figure S101.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S101.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.026 0.005 -10000 0 -10000 0 0
HDAC2 0.026 0.005 -10000 0 -10000 0 0
GNB1/GNG2 0.033 0.069 -10000 0 -0.27 25 25
forebrain development -0.011 0.14 0.36 2 -0.48 31 33
GNAO1 0.018 0.084 -10000 0 -0.44 17 17
SMO/beta Arrestin2 0.02 0.067 -10000 0 -0.32 20 20
SMO 0.009 0.088 -10000 0 -0.44 20 20
ARRB2 0.022 0.011 -10000 0 -10000 0 0
GLI3/SPOP 0.038 0.1 0.25 2 -0.51 7 9
mol:GTP 0 0.001 -10000 0 -10000 0 0
GSK3B 0.025 0.028 -10000 0 -0.44 2 2
GNAI2 0.026 0.006 -10000 0 -10000 0 0
SIN3/HDAC complex 0.046 0.04 -10000 0 -0.25 4 4
GNAI1 0.018 0.063 -10000 0 -0.44 10 10
XPO1 0.018 0.066 -10000 0 -0.44 11 11
GLI1/Su(fu) -0.018 0.14 -10000 0 -0.58 18 18
SAP30 0.024 0.029 -10000 0 -0.44 2 2
mol:GDP 0.009 0.088 -10000 0 -0.44 20 20
MIM/GLI2A 0.017 0.062 -10000 0 -0.44 9 9
IFT88 0.017 0.041 -10000 0 -0.44 4 4
GNAI3 0.026 0.006 -10000 0 -10000 0 0
GLI2 -0.003 0.078 -10000 0 -0.34 16 16
GLI3 0.027 0.1 0.27 4 -0.53 7 11
CSNK1D 0.026 0.004 -10000 0 -10000 0 0
CSNK1E 0.025 0.006 -10000 0 -10000 0 0
SAP18 0.021 0.011 -10000 0 -10000 0 0
embryonic digit morphogenesis 0.017 0.041 -10000 0 -0.44 4 4
GNG2 0.021 0.045 -10000 0 -0.44 5 5
Gi family/GTP -0.009 0.1 -10000 0 -0.27 55 55
SIN3B 0.025 0.02 -10000 0 -0.44 1 1
SIN3A 0.024 0.021 -10000 0 -0.44 1 1
GLI3/Su(fu) 0.027 0.093 0.26 3 -0.42 9 12
GLI2/Su(fu) -0.001 0.089 -10000 0 -0.35 21 21
FOXA2 -0.019 0.19 -10000 0 -0.79 27 27
neural tube patterning -0.011 0.14 0.36 2 -0.48 31 33
SPOP 0.026 0.004 -10000 0 -10000 0 0
Su(fu)/PIAS1 0.016 0.056 -10000 0 -0.36 2 2
GNB1 0.025 0.006 -10000 0 -10000 0 0
CSNK1G2 0.025 0.028 -10000 0 -0.44 2 2
CSNK1G3 0.025 0.02 -10000 0 -0.44 1 1
MTSS1 0.017 0.062 -10000 0 -0.44 9 9
embryonic limb morphogenesis -0.011 0.14 0.36 2 -0.48 31 33
SUFU 0.009 0.043 -10000 0 -0.2 20 20
LGALS3 0.024 0.021 -10000 0 -0.44 1 1
catabolic process 0.031 0.12 -10000 0 -0.47 14 14
GLI3A/CBP 0.022 0.055 -10000 0 -0.33 13 13
KIF3A 0.018 0.062 -10000 0 -0.44 10 10
GLI1 -0.011 0.14 0.36 2 -0.5 30 32
RAB23 0.023 0.04 -10000 0 -0.44 4 4
CSNK1A1 0.024 0.028 -10000 0 -0.44 2 2
IFT172 0.027 0 -10000 0 -10000 0 0
RBBP7 0.025 0.02 -10000 0 -0.44 1 1
Su(fu)/Galectin3 0.016 0.057 -10000 0 -0.27 5 5
GNAZ 0.015 0.072 -10000 0 -0.42 14 14
RBBP4 0.025 0.02 -10000 0 -0.44 1 1
CSNK1G1 0.024 0.021 -10000 0 -0.44 1 1
PIAS1 0.025 0.006 -10000 0 -10000 0 0
PRKACA 0.026 0.003 -10000 0 -10000 0 0
GLI2/SPOP 0.011 0.078 -10000 0 -0.33 14 14
STK36 0.027 0.009 -10000 0 -10000 0 0
Gi family/GNB1/GNG2/GDP -0.011 0.1 -10000 0 -0.41 21 21
PTCH1 -0.015 0.16 0.38 1 -0.82 14 15
MIM/GLI1 -0.004 0.15 0.39 1 -0.56 26 27
CREBBP 0.022 0.055 -10000 0 -0.33 13 13
Su(fu)/SIN3/HDAC complex 0.017 0.082 -10000 0 -0.32 20 20
Insulin-mediated glucose transport

Figure S102.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S102.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Insulin responsive Vesicles -0.098 0.17 -10000 0 -0.4 94 94
CaM/Ca2+ 0.018 0.005 -10000 0 -10000 0 0
AKT1 0.024 0.021 -10000 0 -0.44 1 1
AKT2 0.025 0.021 -10000 0 -0.44 1 1
STXBP4 0.021 0.048 -10000 0 -0.44 6 6
mol:GTP 0 0 -10000 0 -10000 0 0
mol:glucose -0.12 0.18 -10000 0 -0.42 98 98
YWHAZ 0.021 0.029 -10000 0 -0.44 2 2
CALM1 0.025 0.007 -10000 0 -10000 0 0
YWHAQ 0.027 0.002 -10000 0 -10000 0 0
TBC1D4 -0.01 0.023 -10000 0 -0.32 3 3
mol:Ca2+ 0 0 -10000 0 -10000 0 0
YWHAH 0.026 0.005 -10000 0 -10000 0 0
YWHAB 0.015 0.013 -10000 0 -10000 0 0
SNARE/Synip 0.04 0.038 -10000 0 -0.26 6 6
YWHAG 0.026 0.005 -10000 0 -10000 0 0
ASIP 0.003 0.018 -10000 0 -10000 0 0
PRKCI 0.024 0.034 -10000 0 -0.44 3 3
AS160/CaM/Ca2+ 0.018 0.005 -10000 0 -10000 0 0
RHOQ 0.027 0.002 -10000 0 -10000 0 0
GYS1 0.005 0.033 0.14 1 -0.34 4 5
PRKCZ 0.025 0.021 -10000 0 -0.44 1 1
TRIP10 0.025 0.02 -10000 0 -0.44 1 1
TC10/GTP/CIP4/Exocyst 0.035 0.014 -10000 0 -0.27 1 1
AS160/14-3-3 0.008 0.048 -10000 0 -0.29 6 6
VAMP2 0.022 0.01 -10000 0 -10000 0 0
SLC2A4 -0.13 0.2 -10000 0 -0.48 98 98
STX4 0.026 0.003 -10000 0 -10000 0 0
GSK3B 0.015 0.035 -10000 0 -0.42 3 3
SFN 0.025 0.023 -10000 0 -0.44 1 1
LNPEP 0.021 0.044 -10000 0 -0.44 5 5
YWHAE 0.022 0.01 -10000 0 -10000 0 0
ceramide signaling pathway

Figure S103.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S103.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAP4K4 0.005 0.072 -10000 0 -0.33 8 8
BAG4 0.022 0.022 -10000 0 -0.44 1 1
BAD 0.005 0.035 0.15 4 -0.4 1 5
NFKBIA 0.025 0.007 -10000 0 -10000 0 0
BIRC3 0.016 0.074 -10000 0 -0.44 14 14
BAX 0.007 0.044 0.19 11 -0.4 1 12
EnzymeConsortium:3.1.4.12 0.004 0.021 0.1 4 -0.076 7 11
IKBKB 0.018 0.081 0.3 2 -0.31 3 5
MAP2K2 0.003 0.047 0.19 17 -0.35 1 18
MAP2K1 0.001 0.045 0.19 15 -0.22 3 18
SMPD1 0.004 0.028 0.14 4 -0.16 5 9
GO:0005551 0 0 -10000 0 -10000 0 0
FADD/Caspase 8 0.01 0.073 -10000 0 -0.32 7 7
MAP2K4 0.001 0.036 0.18 3 -0.22 6 9
protein ubiquitination 0.01 0.076 0.32 3 -0.34 6 9
EnzymeConsortium:2.7.1.37 0.002 0.049 0.19 16 -0.26 2 18
response to UV 0 0.001 0.002 17 -0.002 1 18
RAF1 0.005 0.045 0.19 17 -0.2 2 19
CRADD 0.026 0.003 -10000 0 -10000 0 0
mol:ceramide 0.008 0.034 0.14 7 -0.12 8 15
I-kappa-B-alpha/RELA/p50/ubiquitin 0.033 0.01 -10000 0 -10000 0 0
MADD 0.026 0.003 -10000 0 -10000 0 0
MAP3K1 0.003 0.039 0.16 4 -0.23 6 10
TRADD 0.026 0.003 -10000 0 -10000 0 0
RELA/p50 0.026 0.004 -10000 0 -10000 0 0
MAPK3 0.005 0.046 0.19 16 -0.24 2 18
MAPK1 0.002 0.05 0.19 15 -0.22 5 20
p50/RELA/I-kappa-B-alpha 0.036 0.011 -10000 0 -10000 0 0
FADD 0.007 0.069 0.21 1 -0.3 7 8
KSR1 0.007 0.045 0.18 17 -0.18 3 20
MAPK8 -0.002 0.039 0.22 3 -0.22 7 10
TRAF2 0.025 0.02 -10000 0 -0.44 1 1
response to radiation 0 0 0.002 6 -10000 0 6
CHUK 0.001 0.071 0.25 1 -0.36 6 7
TNF R/SODD 0.033 0.021 -10000 0 -0.32 1 1
TNF 0.011 0.086 -10000 0 -0.44 19 19
CYCS 0.025 0.058 0.16 26 -0.26 4 30
IKBKG 0.004 0.073 0.23 2 -0.36 6 8
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD 0.01 0.073 -10000 0 -0.3 10 10
RELA 0.026 0.004 -10000 0 -10000 0 0
RIPK1 0.026 0.004 -10000 0 -10000 0 0
AIFM1 0.023 0.049 0.14 26 -0.42 1 27
TNF/TNF R/SODD 0.035 0.06 -10000 0 -0.27 18 18
TNFRSF1A 0.026 0.005 -10000 0 -10000 0 0
response to heat 0 0 0.002 6 -10000 0 6
CASP8 0.019 0.098 -10000 0 -0.6 13 13
NSMAF 0.025 0.085 0.2 53 -0.29 6 59
response to hydrogen peroxide 0 0.001 0.002 17 -0.002 1 18
BCL2 0.015 0.05 -10000 0 -0.44 6 6
Stabilization and expansion of the E-cadherin adherens junction

Figure S104.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S104.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
adherens junction organization 0.017 0.034 -10000 0 -0.23 10 10
epithelial cell differentiation 0.053 0.025 -10000 0 -0.23 3 3
CYFIP2 0.019 0.059 -10000 0 -0.44 9 9
ENAH -0.026 0.049 0.26 1 -0.39 4 5
EGFR 0.02 0.045 -10000 0 -0.44 5 5
EPHA2 0.024 0.029 -10000 0 -0.44 2 2
MYO6 -0.016 0.022 0.17 3 -0.23 3 6
CTNNB1 0.026 0.003 -10000 0 -10000 0 0
ABI1/Sra1/Nap1 0.046 0.05 -10000 0 -0.29 11 11
AQP5 -0.01 0.096 -10000 0 -0.44 25 25
CTNND1 0.026 0.004 -10000 0 -10000 0 0
mol:PI-4-5-P2 -0.016 0.026 0.17 5 -0.22 4 9
regulation of calcium-dependent cell-cell adhesion -0.03 0.059 0.18 5 -0.23 38 43
EGF -0.03 0.17 -10000 0 -0.44 80 80
NCKAP1 0.025 0.028 -10000 0 -0.44 2 2
AQP3 0.003 0.06 -10000 0 -0.43 9 9
cortical microtubule organization 0.053 0.025 -10000 0 -0.23 3 3
GO:0000145 -0.015 0.024 0.16 5 -0.21 4 9
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.058 0.026 -10000 0 -0.24 3 3
MLLT4 0.025 0.02 -10000 0 -0.44 1 1
ARF6/GDP -0.027 0.029 -10000 0 -0.27 6 6
ARF6 0.024 0.021 -10000 0 -0.44 1 1
Ephrin A1/EPHA2/NCK1/GIT1 0.058 0.039 -10000 0 -0.3 4 4
mol:Ca2+ 0 0 -10000 0 -10000 0 0
VASP -0.005 0.02 0.17 1 -0.21 4 5
PVRL2 0.026 0.02 -10000 0 -0.44 1 1
ZYX -0.017 0.021 0.17 1 -0.23 4 5
ARF6/GTP 0.061 0.045 -10000 0 -0.34 4 4
CDH1 0.026 0.02 -10000 0 -0.44 1 1
EGFR/EGFR/EGF/EGF 0.01 0.098 -10000 0 -0.22 78 78
RhoA/GDP 0.053 0.028 -10000 0 -0.23 4 4
actin cytoskeleton organization -0.018 0.022 0.16 2 -0.22 5 7
IGF-1R heterotetramer 0.025 0.021 -10000 0 -0.44 1 1
GIT1 0.025 0.02 -10000 0 -0.44 1 1
IGF1R 0.025 0.021 -10000 0 -0.44 1 1
IGF1 -0.008 0.13 -10000 0 -0.44 47 47
DIAPH1 0.028 0.13 -10000 0 -0.58 22 22
Wnt receptor signaling pathway -0.053 0.025 0.23 3 -10000 0 3
RHOA 0.025 0.02 -10000 0 -0.44 1 1
RhoA/GTP -0.028 0.029 -10000 0 -0.26 7 7
CTNNA1 0.025 0.028 -10000 0 -0.44 2 2
VCL -0.018 0.023 0.16 2 -0.22 5 7
EFNA1 0.026 0.004 -10000 0 -10000 0 0
LPP -0.018 0.025 0.16 5 -0.22 4 9
Ephrin A1/EPHA2 0.044 0.031 -10000 0 -0.22 5 5
SEC6/SEC8 -0.025 0.02 -10000 0 -0.22 5 5
MGAT3 -0.03 0.059 0.18 5 -0.23 38 43
HGF/MET 0.032 0.067 -10000 0 -0.22 34 34
HGF 0.001 0.11 -10000 0 -0.44 31 31
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.017 0.035 -10000 0 -0.23 10 10
actin cable formation -0.011 0.071 0.23 15 -0.31 9 24
KIAA1543 -0.016 0.024 0.16 5 -0.22 4 9
KIFC3 -0.019 0.029 0.17 1 -0.23 9 10
NCK1 0.025 0.028 -10000 0 -0.44 2 2
EXOC3 0.026 0.004 -10000 0 -10000 0 0
ACTN1 -0.015 0.024 0.17 5 -0.23 3 8
NCK1/GIT1 0.036 0.027 -10000 0 -0.32 3 3
mol:GDP 0.053 0.025 -10000 0 -0.23 3 3
EXOC4 0.026 0.005 -10000 0 -10000 0 0
STX4 -0.017 0.02 0.17 2 -0.23 3 5
PIP5K1C -0.016 0.026 0.17 5 -0.23 4 9
LIMA1 0.021 0.052 -10000 0 -0.44 7 7
ABI1 0.026 0.02 -10000 0 -0.44 1 1
ROCK1 -0.021 0.052 0.26 4 -0.43 2 6
adherens junction assembly -0.007 0.059 0.27 4 -0.4 6 10
IGF-1R heterotetramer/IGF1 0.026 0.08 -10000 0 -0.23 48 48
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.037 0.023 -10000 0 -0.32 2 2
MET 0.025 0.021 -10000 0 -0.44 1 1
PLEKHA7 -0.016 0.026 0.17 5 -0.23 4 9
mol:GTP 0.056 0.038 -10000 0 -0.3 4 4
establishment of epithelial cell apical/basal polarity -0.016 0.052 0.31 3 -10000 0 3
cortical actin cytoskeleton stabilization 0.017 0.034 -10000 0 -0.23 10 10
regulation of cell-cell adhesion -0.018 0.022 0.16 2 -0.22 5 7
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.017 0.035 -10000 0 -0.23 10 10
Sumoylation by RanBP2 regulates transcriptional repression

Figure S105.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S105.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.026 0.005 -9999 0 -10000 0 0
Ran/GTP/Exportin 1/HDAC4 -0.027 0.073 -9999 0 -0.4 19 19
MDM2/SUMO1 0.016 0.1 -9999 0 -0.43 22 22
HDAC4 0.027 0.004 -9999 0 -10000 0 0
Ran/GTP/Exportin 1/HDAC1 -0.026 0.073 -9999 0 -0.4 19 19
SUMO1 0.011 0.085 -9999 0 -0.44 19 19
NPC/RanGAP1/SUMO1 -0.006 0.082 -9999 0 -0.37 24 24
mol:GTP 0 0 -9999 0 -10000 0 0
XPO1 -0.017 0.1 -9999 0 -0.44 24 24
EntrezGene:23636 0 0 -9999 0 -10000 0 0
RAN 0.026 0.003 -9999 0 -10000 0 0
EntrezGene:8021 0 0 -9999 0 -10000 0 0
RANBP2 0.012 0.083 -9999 0 -0.44 18 18
SUMO1/HDAC4 0.017 0.096 -9999 0 -0.42 22 22
SUMO1/HDAC1 0.017 0.095 -9999 0 -0.43 21 21
RANGAP1 0.025 0.021 -9999 0 -0.44 1 1
MDM2/SUMO1/SUMO1 0.041 0.066 -9999 0 -0.26 19 19
NPC/RanGAP1/SUMO1/RanBP2/Ubc9 -0.004 0.081 -9999 0 -0.36 24 24
Ran/GTP 0.007 0.081 -9999 0 -0.33 25 25
EntrezGene:23225 0 0 -9999 0 -10000 0 0
MDM2 0.025 0.028 -9999 0 -0.44 2 2
UBE2I 0.026 0.004 -9999 0 -10000 0 0
Ran/GTP/Exportin 1 0 0.1 -9999 0 -0.54 16 16
NPC 0.008 0.042 -9999 0 -0.22 18 18
PIAS2 0.02 0.012 -9999 0 -10000 0 0
PIAS1 0.025 0.006 -9999 0 -10000 0 0
EntrezGene:9972 0 0 -9999 0 -10000 0 0
Regulation of nuclear SMAD2/3 signaling

Figure S106.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S106.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EP300 0.023 0.03 -10000 0 -0.44 2 2
HSPA8 0.024 0.028 -10000 0 -0.44 2 2
SMAD3/SMAD4/ER alpha 0.021 0.091 0.23 2 -0.28 30 32
AKT1 0.023 0.028 -10000 0 -0.3 2 2
GSC -0.014 0.15 -10000 0 -1.2 5 5
NKX2-5 0.02 0.02 -10000 0 -0.12 2 2
muscle cell differentiation 0.027 0.12 0.37 18 -10000 0 18
SMAD2-3/SMAD4/SP1 0.043 0.085 -10000 0 -0.28 10 10
SMAD4 0.016 0.037 -10000 0 -0.18 1 1
CBFB 0.024 0.034 -10000 0 -0.44 3 3
SAP18 0.021 0.011 -10000 0 -10000 0 0
Cbp/p300/MSG1 0.04 0.075 -10000 0 -0.27 27 27
SMAD3/SMAD4/VDR 0.049 0.068 -10000 0 -0.3 3 3
MYC 0.018 0.046 -10000 0 -0.45 5 5
CDKN2B -0.028 0.21 -10000 0 -1.2 15 15
AP1 0.013 0.076 -10000 0 -0.29 20 20
SMAD2/SMAD2/SMAD4/SnoN/SIN3/HDAC complex/NCoR1 -0.025 0.13 -10000 0 -0.36 44 44
SMAD2-3/SMAD4/FOXO1-3a-4/FOXG1 -0.032 0.11 -10000 0 -0.35 38 38
SP3 0.027 0.02 -10000 0 -0.44 1 1
CREB1 0.025 0.028 -10000 0 -0.44 2 2
FOXH1 0.005 0.099 -10000 0 -0.44 25 25
SMAD3/SMAD4/GR 0.023 0.081 -10000 0 -0.29 18 18
GATA3 0.004 0.09 -10000 0 -0.45 17 17
SKI/SIN3/HDAC complex/NCoR1 0.01 0.077 -10000 0 -0.31 15 15
MEF2C/TIF2 0.003 0.082 -10000 0 -0.33 10 10
endothelial cell migration 0.006 0.18 1.2 12 -10000 0 12
MAX 0.025 0.009 -10000 0 -10000 0 0
RBBP7 0.025 0.02 -10000 0 -0.44 1 1
RBBP4 0.025 0.02 -10000 0 -0.44 1 1
RUNX2 0.018 0.066 -10000 0 -0.44 11 11
RUNX3 0.017 0.07 -10000 0 -0.44 12 12
RUNX1 0.025 0.006 -10000 0 -10000 0 0
CTBP1 0.025 0.02 -10000 0 -0.44 1 1
NR3C1 0.013 0.08 -10000 0 -0.43 17 17
VDR 0.026 0.02 -10000 0 -0.44 1 1
CDKN1A -0.002 0.11 -10000 0 -1.1 4 4
KAT2B 0.012 0.079 -10000 0 -0.44 16 16
SMAD2/SMAD2/SMAD4/FOXH1 0.019 0.081 -10000 0 -0.28 28 28
DCP1A 0.026 0.004 -10000 0 -10000 0 0
SKI 0.025 0.006 -10000 0 -10000 0 0
SERPINE1 -0.006 0.18 -10000 0 -1.2 12 12
SMAD3/SMAD4/ATF2 0.029 0.063 -10000 0 -0.25 7 7
SMAD3/SMAD4/ATF3 0.031 0.062 -10000 0 -0.25 6 6
SAP30 0.024 0.029 -10000 0 -0.44 2 2
Cbp/p300/PIAS3 0.047 0.033 -10000 0 -0.27 3 3
JUN -0.003 0.069 -10000 0 -0.3 17 17
SMAD3/SMAD4/IRF7 0.028 0.066 -10000 0 -0.27 9 9
TFE3 0.027 0.015 -10000 0 -10000 0 0
COL1A2 -0.011 0.17 -10000 0 -0.83 22 22
mesenchymal cell differentiation -0.025 0.073 0.26 16 -10000 0 16
DLX1 0.02 0.047 -10000 0 -0.44 3 3
TCF3 0.025 0.02 -10000 0 -0.44 1 1
FOS 0.009 0.085 -10000 0 -0.45 17 17
SMAD3/SMAD4/Max 0.03 0.06 -10000 0 -0.22 5 5
Cbp/p300/SNIP1 0.047 0.027 -10000 0 -0.27 2 2
ZBTB17 0.024 0.022 -10000 0 -0.45 1 1
LAMC1 0.004 0.041 -10000 0 -10000 0 0
TGIF2/HDAC complex/SMAD3/SMAD4 0.019 0.053 -10000 0 -0.28 6 6
IRF7 0.023 0.041 -10000 0 -0.38 5 5
ESR1 0.003 0.1 0.17 1 -0.43 27 28
HNF4A 0.009 0.053 -10000 0 -0.44 7 7
MEF2C 0.001 0.086 0.2 1 -0.32 10 11
SMAD2-3/SMAD4 0.032 0.064 -10000 0 -0.25 4 4
Cbp/p300/Src-1 0.048 0.034 -10000 0 -0.39 2 2
IGHV3OR16-13 0.005 0.045 -10000 0 -0.7 2 2
TGIF2/HDAC complex 0.011 0.045 -10000 0 -0.44 5 5
CREBBP 0.025 0.01 -10000 0 -10000 0 0
SKIL 0.017 0.065 -10000 0 -0.44 11 11
HDAC1 0.026 0.005 -10000 0 -10000 0 0
HDAC2 0.026 0.005 -10000 0 -10000 0 0
SNIP1 0.026 0.005 -10000 0 -10000 0 0
GCN5L2 0 0.005 -10000 0 -10000 0 0
SMAD3/SMAD4/TFE3 0.035 0.062 -10000 0 -0.23 4 4
MSG1/HSC70 0.028 0.08 -10000 0 -0.32 27 27
SMAD2 0.019 0.029 -10000 0 -0.44 1 1
SMAD3 0.014 0.053 -10000 0 -0.34 5 5
SMAD3/E2F4-5/DP1/p107/SMAD4 -0.001 0.054 -10000 0 -0.24 13 13
SMAD2/SMAD2/SMAD4 -0.055 0.12 -10000 0 -0.33 55 55
NCOR1 0.022 0.01 -10000 0 -10000 0 0
NCOA2 0.018 0.049 -10000 0 -0.44 6 6
NCOA1 0.026 0.02 -10000 0 -0.44 1 1
MYOD/E2A 0.032 0.017 -10000 0 -0.32 1 1
SMAD2-3/SMAD4/SP1/MIZ-1 0.05 0.088 -10000 0 -0.29 8 8
IFNB1 -0.005 0.046 -10000 0 -0.3 3 3
SMAD3/SMAD4/MEF2C 0.023 0.099 -10000 0 -0.35 8 8
CITED1 0.015 0.1 -10000 0 -0.44 25 25
SMAD2-3/SMAD4/ARC105 0.041 0.068 -10000 0 -0.26 4 4
RBL1 0.015 0.03 -10000 0 -0.44 2 2
SMAD2-3/SMAD4/FOXO1-3a-4/CEBPB -0.002 0.11 -10000 0 -0.41 28 28
RUNX1-3/PEBPB2 0.042 0.054 -10000 0 -0.27 14 14
SMAD7 0.006 0.1 -10000 0 -0.47 12 12
MYC/MIZ-1 0.027 0.043 0.18 8 -0.32 6 14
SMAD3/SMAD4 -0.038 0.11 0.25 3 -0.4 31 34
IL10 -0.029 0.13 -10000 0 -0.46 41 41
PIASy/HDAC complex 0.024 0.023 -10000 0 -0.44 1 1
PIAS3 0.025 0.021 -10000 0 -0.44 1 1
CDK2 0.025 0.022 -10000 0 -0.44 1 1
IL5 -0.016 0.081 -10000 0 -0.28 30 30
CDK4 0.026 0.009 -10000 0 -10000 0 0
PIAS4 0.024 0.023 -10000 0 -0.44 1 1
ATF3 0.027 0.024 -10000 0 -0.44 1 1
SMAD3/SMAD4/SP1 0.03 0.079 -10000 0 -0.26 16 16
FOXG1 -0.008 0.074 -10000 0 -0.44 12 12
FOXO3 0.009 0.022 -10000 0 -0.23 2 2
FOXO1 0.007 0.021 -10000 0 -0.32 1 1
FOXO4 0.008 0.027 -10000 0 -0.28 3 3
heart looping 0.001 0.085 0.2 1 -0.31 10 11
CEBPB 0.014 0.025 -10000 0 -0.44 1 1
SMAD3/SMAD4/DLX1 0.031 0.069 -10000 0 -0.24 9 9
MYOD1 -0.017 0.01 -10000 0 -10000 0 0
SMAD3/SMAD4/HNF4 0.017 0.057 -10000 0 -0.3 8 8
SMAD3/SMAD4/GATA3 0.017 0.11 -10000 0 -0.28 52 52
SnoN/SIN3/HDAC complex/NCoR1 0.017 0.065 -10000 0 -0.44 11 11
SMAD3/SMAD4/RUNX1-3/PEBPB2 0.042 0.08 -10000 0 -0.24 16 16
SMAD3/SMAD4/SP1-3 0.043 0.08 -10000 0 -0.26 8 8
MED15 0.025 0.021 -10000 0 -0.44 1 1
SP1 0.022 0.04 -10000 0 -0.16 20 20
SIN3B 0.026 0.02 -10000 0 -0.44 1 1
SIN3A 0.025 0.021 -10000 0 -0.44 1 1
SMAD2/SMAD2/SMAD4/FOXH1/NKX2-5 0.027 0.083 -10000 0 -0.25 28 28
ITGB5 -0.002 0.052 -10000 0 -0.29 2 2
TGIF/SIN3/HDAC complex/CtBP 0.016 0.062 -10000 0 -0.33 6 6
SMAD3/SMAD4/AR 0.021 0.089 -10000 0 -0.29 26 26
AR 0.008 0.093 -10000 0 -0.44 21 21
negative regulation of cell growth -0.009 0.072 -10000 0 -0.3 16 16
SMAD3/SMAD4/MYOD 0.026 0.059 -10000 0 -0.23 5 5
E2F5 0.012 0.071 -10000 0 -0.44 13 13
E2F4 0.026 0.003 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1/SMIF 0.034 0.082 -10000 0 -0.24 26 26
SMAD2-3/SMAD4/FOXO1-3a-4 0.012 0.09 -10000 0 -0.38 20 20
TFDP1 0.021 0.011 -10000 0 -10000 0 0
SMAD3/SMAD4/AP1 0.028 0.085 -10000 0 -0.3 19 19
SMAD3/SMAD4/RUNX2 0.025 0.073 -10000 0 -0.26 16 16
TGIF2 0.011 0.045 -10000 0 -0.44 5 5
TGIF1 0.021 0.011 -10000 0 -10000 0 0
ATF2 0.025 0.028 -10000 0 -0.44 2 2
ErbB4 signaling events

Figure S107.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S107.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ErbB4/ErbB4/HBEGF/HBEGF 0.049 0.085 -10000 0 -0.75 4 4
epithelial cell differentiation 0.008 0.12 -10000 0 -0.58 8 8
ITCH 0.015 0.036 -10000 0 -0.44 3 3
WWP1 0.006 0.097 -10000 0 -1.2 3 3
FYN 0.023 0.04 -10000 0 -0.44 4 4
EGFR 0.02 0.045 -10000 0 -0.44 5 5
PRL 0.004 0.029 -10000 0 -10000 0 0
neuron projection morphogenesis 0.002 0.092 0.23 11 -0.62 4 15
PTPRZ1 -0.006 0.12 -10000 0 -0.44 34 34
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/GRB2/SHC 0.029 0.099 -10000 0 -0.79 3 3
ErbB4 CYT2/ErbB4 CYT2/neuregulin 1 beta/neuregulin 1 beta 0.001 0.094 -10000 0 -0.72 4 4
ADAM17 0.012 0.038 -10000 0 -0.51 2 2
ErbB4/ErbB4 0.006 0.079 -10000 0 -0.81 4 4
ErbB4/ErbB4/neuregulin 3/neuregulin 3 0.047 0.085 -10000 0 -0.76 4 4
NCOR1 0.022 0.01 -10000 0 -10000 0 0
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/Fyn 0.012 0.099 -10000 0 -0.64 5 5
GRIN2B -0.012 0.11 0.26 3 -0.5 12 15
ErbB4/ErbB2/betacellulin 0.041 0.085 -10000 0 -0.83 3 3
STAT1 0.026 0.029 -10000 0 -0.44 2 2
HBEGF 0.028 0.012 -10000 0 -10000 0 0
PRLR -0.015 0.13 -10000 0 -0.44 49 49
E4ICDs/ETO2 0.036 0.11 -10000 0 -0.5 9 9
axon guidance -0.001 0.1 0.31 3 -0.94 4 7
NEDD4 0.01 0.034 -10000 0 -0.44 2 2
Prolactin receptor/Prolactin receptor/Prolactin 0.005 0.1 -10000 0 -0.33 49 49
CBFA2T3 0.003 0.12 -10000 0 -0.44 37 37
ErbB4/ErbB2/HBEGF 0.047 0.079 -10000 0 -0.83 3 3
MAPK3 0.008 0.092 0.25 5 -0.64 4 9
STAT1 (dimer) 0.049 0.094 -10000 0 -0.84 4 4
MAPK1 0.008 0.09 0.25 4 -0.73 3 7
JAK2 0.014 0.076 -10000 0 -0.44 15 15
ErbB4/ErbB2/neuregulin 1 beta 0.002 0.094 0.22 5 -0.7 4 9
NRG1 -0.035 0.084 -10000 0 -0.33 41 41
NRG3 0.007 0.026 -10000 0 -10000 0 0
NRG2 0.019 0.027 -10000 0 -10000 0 0
NRG4 0.016 0.047 -10000 0 -0.44 4 4
heart development -0.001 0.1 0.31 3 -0.94 4 7
neural crest cell migration 0.002 0.092 0.22 5 -0.68 4 9
ERBB2 -0.008 0.039 0.24 7 -0.35 3 10
WWOX/E4ICDs 0.047 0.085 -10000 0 -0.75 4 4
SHC1 0.026 0.004 -10000 0 -10000 0 0
ErbB4/EGFR/neuregulin 4 0.05 0.094 -10000 0 -0.72 5 5
apoptosis -0.017 0.1 0.54 9 -10000 0 9
ErbB4/ErbB4/neuregulin 2 beta/neuregulin 2 beta 0.048 0.087 -10000 0 -0.78 4 4
ErbB4/ErbB2/epiregulin -0.006 0.14 -10000 0 -0.54 7 7
ErbB4/ErbB4/betacellulin/betacellulin 0.042 0.091 -10000 0 -0.75 4 4
ErbB4/ErbB4/HBEGF/HBEGF/Prolactin receptor/Prolactin receptor/Prolactin/JAK2 0.046 0.13 -10000 0 -0.6 8 8
MDM2 0.001 0.078 -10000 0 -0.8 4 4
ErbB4 JM-B/ErbB4 JM-B/neuregulin 1 beta/neuregulin 1 beta -0.007 0.084 -10000 0 -0.49 7 7
STAT5A 0.007 0.11 0.3 2 -0.91 4 6
ErbB4/EGFR/neuregulin 1 beta 0.009 0.1 -10000 0 -0.69 5 5
DLG4 0.021 0.03 -10000 0 -0.44 2 2
GRB2/SHC 0.038 0.008 -10000 0 -10000 0 0
E4ICDs/TAB2/NCoR1 0.034 0.078 -10000 0 -0.7 4 4
STAT5A (dimer) 0.02 0.13 0.29 1 -0.66 8 9
MAP3K7IP2 0 0 -10000 0 -10000 0 0
STAT5B (dimer) 0.03 0.11 0.32 1 -0.91 4 5
LRIG1 0.015 0.071 -10000 0 -0.44 13 13
EREG -0.074 0.2 -10000 0 -0.44 127 127
BTC 0.016 0.068 -10000 0 -0.44 12 12
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta -0.005 0.1 0.37 1 -0.97 4 5
ERBB4 0.003 0.077 -10000 0 -0.81 4 4
STAT5B 0.026 0.004 -10000 0 -10000 0 0
YAP1 -0.002 0.1 -10000 0 -0.57 13 13
GRB2 0.026 0.004 -10000 0 -10000 0 0
ErbB4/ErbB2/neuregulin 4 0.046 0.081 -10000 0 -0.84 3 3
glial cell differentiation -0.034 0.077 0.69 4 -10000 0 4
WWOX 0.025 0.028 -10000 0 -0.44 2 2
cell proliferation -0.002 0.12 0.29 2 -0.76 5 7
Signaling events mediated by HDAC Class III

Figure S108.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S108.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EP300 0.024 0.029 -10000 0 -0.44 2 2
HDAC4 0.027 0.004 -10000 0 -10000 0 0
induction of apoptosis 0 0 -10000 0 -10000 0 0
regulation of S phase of mitotic cell cycle 0.021 0.052 0.32 15 -0.16 3 18
CDKN1A -0.001 0.046 -10000 0 -0.58 2 2
KAT2B 0.013 0.078 -10000 0 -0.44 16 16
BAX 0.025 0.02 -10000 0 -0.44 1 1
FOXO3 -0.003 0.028 0.44 2 -10000 0 2
FOXO1 0.02 0.011 -10000 0 -10000 0 0
FOXO4 0.011 0.024 -10000 0 -0.31 3 3
response to UV 0 0 -10000 0 -10000 0 0
XRCC6 0.025 0.006 -10000 0 -10000 0 0
TAT 0.018 0.028 -10000 0 -10000 0 0
mol:Lysophosphatidic acid 0 0 -10000 0 -10000 0 0
MYOD1 -0.025 0.051 -10000 0 -0.32 16 16
PPARGC1A -0.013 0.13 -10000 0 -0.44 47 47
FHL2 0.026 0.02 -10000 0 -0.44 1 1
response to nutrient levels 0 0 -10000 0 -10000 0 0
KU70/SIRT1 0.033 0.032 -10000 0 -0.32 4 4
HIST2H4A -0.021 0.052 0.16 3 -0.32 15 18
SIRT1/FOXO3a 0.019 0.027 0.18 1 -0.25 2 3
SIRT1 0.021 0.041 0.2 1 -0.44 4 5
response to hypoxia 0 0 -10000 0 -10000 0 0
SIRT1/MEF2D/HDAC4 0.048 0.033 -10000 0 -0.27 5 5
SIRT1/Histone H1b 0.012 0.059 0.19 1 -0.25 19 20
apoptosis -0.045 0.034 0.27 5 -10000 0 5
SIRT1/PGC1A 0.006 0.087 -10000 0 -0.27 51 51
p53/SIRT1 0.004 0.091 0.39 1 -0.33 37 38
SIRT1/FOXO4 0.017 0.049 0.19 1 -0.31 7 8
FOXO1/FHL2/SIRT1 0.035 0.034 -10000 0 -0.25 4 4
HIST1H1E 0.005 0.043 -10000 0 -0.26 14 14
SIRT1/p300 0.033 0.044 -10000 0 -0.45 4 4
muscle cell differentiation -0.019 0.063 0.3 18 -0.22 3 21
TP53 -0.008 0.11 0.2 1 -0.45 34 35
KU70/SIRT1/BAX 0.046 0.035 -10000 0 -0.27 5 5
CREBBP 0.026 0.004 -10000 0 -10000 0 0
MEF2D 0.025 0.02 -10000 0 -0.44 1 1
HIV-1 Tat/SIRT1 0.036 0.034 -10000 0 -0.32 4 4
ACSS2 -0.009 0.024 0.13 1 -0.32 3 4
SIRT1/PCAF/MYOD 0.019 0.063 0.22 3 -0.31 18 21
Role of Calcineurin-dependent NFAT signaling in lymphocytes

Figure S109.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S109.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.016 0.013 -10000 0 -10000 0 0
NFATC1 -0.036 0.14 0.3 3 -0.4 39 42
NFATC2 0.02 0.064 0.16 4 -0.22 13 17
NFATC3 0.017 0.017 -10000 0 -0.35 1 1
YWHAE 0.022 0.01 -10000 0 -10000 0 0
Calcineurin A alpha-beta B1/CABIN1 -0.046 0.13 0.22 3 -0.4 44 47
Exportin 1/Ran/NUP214 0.047 0.044 -10000 0 -0.27 10 10
mol:DAG 0 0 -10000 0 -10000 0 0
CABIN1/MEF2D/CaM/Ca2+/CAMK IV -0.023 0.14 0.23 1 -0.38 47 48
BCL2/BAX 0.025 0.043 -10000 0 -0.32 7 7
CaM/Ca2+/Calcineurin A alpha-beta B1 0.019 0.006 -10000 0 -10000 0 0
CaM/Ca2+ 0.019 0.006 -10000 0 -10000 0 0
BAX 0.025 0.02 -10000 0 -0.44 1 1
MAPK14 0.026 0.003 -10000 0 -10000 0 0
BAD 0.025 0.02 -10000 0 -0.44 1 1
CABIN1/MEF2D -0.034 0.13 0.22 2 -0.39 42 44
Calcineurin A alpha-beta B1/BCL2 0.015 0.05 -10000 0 -0.44 6 6
FKBP8 0.025 0.028 -10000 0 -0.44 2 2
activation-induced cell death of T cells 0.033 0.13 0.38 42 -0.22 2 44
KPNB1 0.026 0.004 -10000 0 -10000 0 0
KPNA2 0.026 0.005 -10000 0 -10000 0 0
XPO1 0.018 0.065 -10000 0 -0.44 11 11
SFN 0.025 0.023 -10000 0 -0.44 1 1
MAP3K8 0.026 0.02 -10000 0 -0.44 1 1
NFAT4/CK1 alpha 0.021 0.041 -10000 0 -0.3 6 6
MEF2D/NFAT1/Cbp/p300 0.055 0.08 -10000 0 -0.44 4 4
CABIN1 -0.048 0.13 0.19 2 -0.4 44 46
CALM1 0.025 0.007 -10000 0 -10000 0 0
RAN 0.026 0.003 -10000 0 -10000 0 0
MAP3K1 0.022 0.044 -10000 0 -0.44 5 5
CAMK4 0.013 0.077 -10000 0 -0.44 15 15
mol:Ca2+ 0 0.001 -10000 0 -10000 0 0
MAPK3 0.025 0.02 -10000 0 -0.44 1 1
YWHAH 0.026 0.005 -10000 0 -10000 0 0
Calcineurin A alpha-beta B1/AKAP79/PKA 0.029 0.057 -10000 0 -0.32 14 14
YWHAB 0.015 0.013 -10000 0 -10000 0 0
MAPK8 0.025 0.02 -10000 0 -0.44 1 1
MAPK9 0.026 0.004 -10000 0 -10000 0 0
YWHAG 0.026 0.005 -10000 0 -10000 0 0
FKBP1A 0.021 0.011 -10000 0 -10000 0 0
NFAT1-c-4/YWHAQ -0.012 0.14 0.42 1 -0.38 32 33
PRKCH 0.021 0.045 -10000 0 -0.44 5 5
CABIN1/Cbp/p300 0.036 0.024 -10000 0 -0.32 2 2
CASP3 0.025 0.007 -10000 0 -10000 0 0
PIM1 0.026 0.003 -10000 0 -10000 0 0
Calcineurin A alpha-beta B1/FKBP12/FK506 0.015 0.007 -10000 0 -10000 0 0
apoptosis 0.008 0.028 0.19 1 -0.52 1 2
14-3-3 family/BAD/CaM/Ca2+/Calcineurin A alpha-beta B1 0.027 0.054 -10000 0 -0.33 5 5
PRKCB 0 0.11 -10000 0 -0.44 34 34
PRKCE 0.027 0.002 -10000 0 -10000 0 0
JNK2/NFAT4 0.022 0.041 -10000 0 -0.32 1 1
BAD/BCL-XL 0.022 0.024 -10000 0 -0.32 1 1
PRKCD 0.026 0.004 -10000 0 -10000 0 0
NUP214 0.026 0.003 -10000 0 -10000 0 0
PRKCZ 0.025 0.021 -10000 0 -0.45 1 1
PRKCA 0.025 0.02 -10000 0 -0.44 1 1
PRKCG -0.024 0.16 -10000 0 -0.44 71 71
PRKCQ -0.015 0.13 -10000 0 -0.44 49 49
FKBP38/BCL2 0.024 0.045 -10000 0 -0.32 8 8
EP300 0.024 0.029 -10000 0 -0.44 2 2
PRKCB1 0 0 -10000 0 -10000 0 0
CSNK2A1 0.021 0.011 -10000 0 -10000 0 0
NFATc/JNK1 -0.022 0.14 0.3 3 -0.38 39 42
CaM/Ca2+/FKBP38 0.033 0.021 -10000 0 -0.27 2 2
FKBP12/FK506 0.016 0.008 -10000 0 -10000 0 0
CSNK1A1 0.009 0.018 -10000 0 -0.27 2 2
CaM/Ca2+/CAMK IV 0.025 0.049 -10000 0 -0.26 15 15
NFATc/ERK1 -0.024 0.14 0.32 2 -0.38 37 39
CABIN1/YWHAQ/CaM/Ca2+/CAMK IV -0.023 0.14 0.23 1 -0.39 45 46
NR4A1 0.022 0.073 0.24 4 -0.44 4 8
GSK3B 0.025 0.028 -10000 0 -0.44 2 2
positive T cell selection 0.017 0.017 -10000 0 -0.35 1 1
NFAT1/CK1 alpha 0.02 0.052 0.15 1 -0.25 6 7
RCH1/ KPNB1 0.038 0.008 -10000 0 -10000 0 0
YWHAQ 0.027 0.002 -10000 0 -10000 0 0
PRKACA 0.026 0.003 -10000 0 -10000 0 0
AKAP5 0.015 0.075 -10000 0 -0.44 14 14
MEF2D 0.025 0.021 -10000 0 -0.45 1 1
mol:FK506 0 0 -10000 0 -10000 0 0
YWHAZ 0.021 0.029 -10000 0 -0.44 2 2
NFATc/p38 alpha -0.024 0.14 0.32 2 -0.38 38 40
CREBBP 0.026 0.004 -10000 0 -10000 0 0
BCL2 0.015 0.05 -10000 0 -0.44 6 6
TCGA08_rtk_signaling

Figure S110.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S110.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRA 0.011 0.083 -10000 0 -0.44 18 18
HRAS 0.026 0.021 -10000 0 -0.44 1 1
EGFR 0.02 0.045 -10000 0 -0.44 5 5
AKT 0.034 0.084 0.24 18 -0.3 15 33
FOXO3 0.026 0.005 -10000 0 -10000 0 0
AKT1 0.024 0.021 -10000 0 -0.44 1 1
FOXO1 0.02 0.011 -10000 0 -10000 0 0
AKT3 0.018 0.066 -10000 0 -0.44 11 11
FOXO4 0.026 0.02 -10000 0 -0.44 1 1
MET 0.025 0.021 -10000 0 -0.44 1 1
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
PIK3CB 0.024 0.034 -10000 0 -0.44 3 3
NRAS 0.018 0.059 -10000 0 -0.44 9 9
PIK3CG -0.004 0.12 -10000 0 -0.44 37 37
PIK3R3 0.024 0.034 -10000 0 -0.44 3 3
PIK3R2 0.026 0.02 -10000 0 -0.44 1 1
NF1 0.023 0.035 -10000 0 -0.44 3 3
RAS 0.014 0.052 0.16 3 -0.17 26 29
ERBB2 0.025 0.021 -10000 0 -0.44 1 1
proliferation/survival/translation -0.025 0.069 0.27 16 -0.23 3 19
PI3K 0.022 0.071 0.21 28 -0.25 13 41
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
KRAS 0.022 0.044 -10000 0 -0.44 5 5
FOXO 0.058 0.053 0.21 23 -0.12 4 27
AKT2 0.025 0.021 -10000 0 -0.44 1 1
PTEN 0.025 0.006 -10000 0 -10000 0 0
HIF-2-alpha transcription factor network

Figure S111.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S111.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MMP14 0.01 0.14 -10000 0 -0.56 32 32
oxygen homeostasis 0.003 0.008 -10000 0 -10000 0 0
TCEB2 0.026 0.022 -10000 0 -0.44 1 1
TCEB1 0.023 0.009 -10000 0 -10000 0 0
VHL/Elongin B/Elongin C/HIF2A 0.041 0.077 -10000 0 -0.35 3 3
EPO 0.045 0.12 -10000 0 -0.42 8 8
FIH (dimer) 0.024 0.02 -10000 0 -10000 0 0
APEX1 0.024 0.023 -10000 0 -10000 0 0
SERPINE1 0.037 0.14 -10000 0 -0.52 16 16
FLT1 0.018 0.12 -10000 0 -0.65 14 14
ADORA2A 0.033 0.12 0.32 5 -0.47 9 14
germ cell development 0.036 0.14 -10000 0 -0.48 21 21
SLC11A2 0.043 0.12 -10000 0 -0.46 9 9
BHLHE40 0.043 0.12 -10000 0 -0.46 9 9
HIF1AN 0.024 0.02 -10000 0 -10000 0 0
HIF2A/ARNT/SIRT1 0.051 0.095 -10000 0 -0.35 5 5
ETS1 0.031 0.034 -10000 0 -0.44 2 2
CITED2 0.024 0.1 -10000 0 -0.62 11 11
KDR 0.018 0.14 -10000 0 -0.68 18 18
PGK1 0.043 0.12 -10000 0 -0.46 9 9
SIRT1 0.023 0.04 -10000 0 -0.44 4 4
response to hypoxia 0 0 -10000 0 -10000 0 0
HIF2A/ARNT 0.085 0.15 -10000 0 -0.52 9 9
EPAS1 0.021 0.056 0.18 1 -0.31 3 4
SP1 0.029 0.02 -10000 0 -0.44 1 1
ABCG2 0.034 0.15 -10000 0 -0.49 27 27
EFNA1 0.043 0.12 -10000 0 -0.46 9 9
FXN 0.034 0.12 0.32 6 -0.45 10 16
POU5F1 0.036 0.14 -10000 0 -0.49 21 21
neuron apoptosis -0.083 0.15 0.51 9 -10000 0 9
EP300 0.024 0.029 -10000 0 -0.44 2 2
EGLN3 0.021 0.045 -10000 0 -0.44 4 4
EGLN2 0.024 0.028 -10000 0 -0.46 1 1
EGLN1 0.024 0.02 -10000 0 -10000 0 0
VHL/Elongin B/Elongin C 0.045 0.029 -10000 0 -0.29 2 2
VHL 0.025 0.02 -10000 0 -0.44 1 1
ARNT 0.024 0.03 -10000 0 -0.44 1 1
SLC2A1 0.033 0.12 0.32 5 -0.45 9 14
TWIST1 0.017 0.15 0.32 4 -0.48 30 34
ELK1 0.029 0.021 -10000 0 -0.44 1 1
HIF2A/ARNT/Cbp/p300 0.06 0.099 -10000 0 -0.35 4 4
VEGFA 0.043 0.12 -10000 0 -0.46 9 9
CREBBP 0.026 0.004 -10000 0 -10000 0 0
FoxO family signaling

Figure S112.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S112.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
G6PC 0.025 0.066 0.5 2 -10000 0 2
PLK1 0.013 0.13 0.51 1 -0.84 3 4
CDKN1B 0.058 0.11 0.44 5 -0.38 14 19
FOXO3 0.023 0.12 -10000 0 -0.53 9 9
KAT2B 0.014 0.081 -10000 0 -0.45 16 16
FOXO1/SIRT1 0.04 0.061 0.25 3 -0.28 5 8
CAT 0.014 0.12 -10000 0 -0.69 2 2
CTNNB1 0.026 0.003 -10000 0 -10000 0 0
AKT1 0.026 0.028 -10000 0 -0.44 1 1
FOXO1 0.032 0.068 0.36 5 -0.25 3 8
MAPK10 0.021 0.074 0.19 48 -0.23 26 74
mol:GTP 0.001 0.001 -10000 0 -10000 0 0
FOXO4 0.028 0.082 0.3 7 -0.57 2 9
response to oxidative stress 0.006 0.009 -10000 0 -10000 0 0
FOXO3A/SIRT1 0.036 0.1 -10000 0 -0.49 6 6
XPO1 0.018 0.065 -10000 0 -0.44 11 11
EP300 0.025 0.029 -10000 0 -0.44 2 2
BCL2L11 0.028 0.025 -10000 0 -10000 0 0
FOXO1/SKP2 0.039 0.062 0.25 4 -0.32 4 8
mol:GDP 0.006 0.009 -10000 0 -10000 0 0
RAN 0.027 0.003 -10000 0 -10000 0 0
GADD45A 0.031 0.14 -10000 0 -0.61 19 19
YWHAQ 0.027 0.002 -10000 0 -10000 0 0
FOXO1/14-3-3 family 0.032 0.13 0.33 2 -0.44 21 23
MST1 0.015 0.089 -10000 0 -0.42 20 20
CSNK1D 0.026 0.004 -10000 0 -10000 0 0
CSNK1E 0.025 0.006 -10000 0 -10000 0 0
FOXO4/14-3-3 family -0.015 0.11 -10000 0 -0.39 29 29
YWHAB 0.015 0.013 -10000 0 -10000 0 0
MAPK8 0.032 0.052 0.19 52 -0.27 1 53
MAPK9 0.032 0.051 0.19 52 -10000 0 52
YWHAG 0.026 0.005 -10000 0 -10000 0 0
YWHAE 0.022 0.01 -10000 0 -10000 0 0
YWHAZ 0.021 0.029 -10000 0 -0.44 2 2
SIRT1 0.024 0.042 -10000 0 -0.44 4 4
SOD2 0.053 0.11 0.46 4 -0.49 6 10
RBL2 0.033 0.13 -10000 0 -1.2 3 3
RAL/GDP 0.037 0.018 -10000 0 -10000 0 0
CHUK 0.024 0.039 -10000 0 -0.44 3 3
Ran/GTP 0.021 0.004 -10000 0 -10000 0 0
CSNK1G2 0.025 0.028 -10000 0 -0.44 2 2
RAL/GTP 0.039 0.016 -10000 0 -10000 0 0
CSNK1G1 0.024 0.021 -10000 0 -0.44 1 1
FASLG -0.064 0.35 -10000 0 -1.3 40 40
SKP2 0.024 0.034 -10000 0 -0.44 3 3
USP7 0.027 0.004 -10000 0 -10000 0 0
IKBKB 0.024 0.019 -10000 0 -10000 0 0
CCNB1 0.016 0.11 -10000 0 -0.69 2 2
FOXO1-3a-4/beta catenin 0.062 0.12 0.4 9 -0.43 2 11
proteasomal ubiquitin-dependent protein catabolic process 0.038 0.061 0.25 4 -0.31 4 8
CSNK1A1 0.024 0.028 -10000 0 -0.44 2 2
SGK1 0.026 0.041 -10000 0 -0.44 3 3
CSNK1G3 0.025 0.02 -10000 0 -0.44 1 1
Ran/GTP/Exportin 1 0.033 0.043 -10000 0 -0.27 11 11
ZFAND5 0.025 0.081 0.33 3 -0.7 2 5
SFN 0.025 0.023 -10000 0 -0.44 1 1
CDK2 0.026 0.02 -10000 0 -0.44 1 1
FOXO3A/14-3-3 -0.009 0.099 -10000 0 -0.38 20 20
CREBBP 0.026 0.004 -10000 0 -10000 0 0
FBXO32 0.043 0.14 0.51 1 -0.69 2 3
BCL6 0.035 0.11 -10000 0 -0.78 2 2
RALB 0.027 0.002 -10000 0 -10000 0 0
RALA 0.025 0.008 -10000 0 -10000 0 0
YWHAH 0.026 0.005 -10000 0 -10000 0 0
E-cadherin signaling in the nascent adherens junction

Figure S113.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S113.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CTTN 0.015 0.039 -10000 0 -0.36 3 3
KLHL20 0.037 0.082 0.2 32 -0.23 22 54
CYFIP2 0.019 0.059 -10000 0 -0.44 9 9
Rac1/GDP 0.059 0.087 0.28 6 -0.34 2 8
ENAH 0.01 0.049 -10000 0 -0.36 4 4
AP1M1 0.026 0.02 -10000 0 -0.44 1 1
RAP1B 0.027 0.002 -10000 0 -10000 0 0
RAP1A 0.025 0.02 -10000 0 -0.44 1 1
CTNNB1 0.026 0.003 -10000 0 -10000 0 0
CDC42/GTP 0.013 0.034 -10000 0 -0.31 1 1
ABI1/Sra1/Nap1 -0.011 0.038 -10000 0 -0.17 25 25
E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.049 0.057 -10000 0 -0.24 16 16
RAPGEF1 0.053 0.084 0.27 7 -0.35 3 10
CTNND1 0.026 0.004 -10000 0 -10000 0 0
regulation of calcium-dependent cell-cell adhesion 0.025 0.039 -10000 0 -0.36 3 3
CRK 0.054 0.081 -10000 0 -0.36 2 2
E-cadherin/gamma catenin/alpha catenin 0.049 0.03 -10000 0 -0.27 4 4
alphaE/beta7 Integrin 0.024 0.063 -10000 0 -0.31 18 18
IQGAP1 0.024 0.029 -10000 0 -0.44 2 2
NCKAP1 0.025 0.028 -10000 0 -0.44 2 2
Rap1/GTP/I-afadin 0.047 0.022 -10000 0 -0.25 2 2
DLG1 0.013 0.042 -10000 0 -0.36 3 3
ChemicalAbstracts:7440-70-2 0 0 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 -0.011 0.022 -10000 0 -0.22 2 2
MLLT4 0.025 0.02 -10000 0 -0.44 1 1
ARF6/GTP/NME1/Tiam1 0.033 0.065 -10000 0 -0.24 26 26
PI3K -0.013 0.028 -10000 0 -0.29 2 2
ARF6 0.024 0.021 -10000 0 -0.44 1 1
mol:Ca2+ 0 0 -10000 0 -10000 0 0
E-cadherin/gamma catenin 0.037 0.022 -10000 0 -0.32 2 2
TIAM1 0.008 0.1 -10000 0 -0.44 26 26
E-cadherin(dimer)/Ca2+ 0.059 0.026 -10000 0 -0.24 3 3
AKT1 0.017 0.049 -10000 0 -0.23 2 2
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
CDH1 0.026 0.02 -10000 0 -0.44 1 1
RhoA/GDP 0.071 0.09 0.3 8 -0.34 2 10
actin cytoskeleton organization 0.032 0.065 0.16 37 -0.17 21 58
CDC42/GDP 0.066 0.091 0.3 9 -0.34 2 11
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.016 0.021 -10000 0 -0.22 4 4
ITGB7 0.013 0.084 -10000 0 -0.44 18 18
RAC1 0.024 0.008 -10000 0 -10000 0 0
E-cadherin/beta catenin/alpha catenin/p120 catenin 0.063 0.028 -10000 0 -0.25 3 3
E-cadherin/Ca2+/beta catenin/alpha catenin 0.044 0.022 -10000 0 -0.23 3 3
mol:GDP 0.062 0.098 0.31 10 -0.4 2 12
CDC42/GTP/IQGAP1 0.029 0.038 -10000 0 -0.38 4 4
JUP 0.025 0.02 -10000 0 -0.44 1 1
p120 catenin/RhoA/GDP 0.08 0.091 0.3 8 -0.35 2 10
RAC1/GTP/IQGAP1 0.03 0.022 -10000 0 -0.27 2 2
PIP5K1C/AP1M1 0.038 0.026 -10000 0 -0.57 1 1
RHOA 0.025 0.02 -10000 0 -0.44 1 1
CDC42 0.022 0.04 -10000 0 -0.44 4 4
CTNNA1 0.025 0.028 -10000 0 -0.44 2 2
positive regulation of S phase of mitotic cell cycle 0.029 0.05 0.14 42 -0.14 4 46
NME1 0.026 0.006 -10000 0 -10000 0 0
clathrin coat assembly 0 0 -10000 0 -10000 0 0
TJP1 0.013 0.04 -10000 0 -0.36 3 3
regulation of cell-cell adhesion 0.007 0.026 -10000 0 -0.23 2 2
WASF2 0.013 0.035 0.091 25 -0.12 3 28
Rap1/GTP 0.073 0.076 0.3 3 -0.35 1 4
E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.061 -10000 0 -0.23 18 18
CCND1 0.033 0.058 0.15 41 -0.18 4 45
VAV2 0.053 0.18 0.4 1 -0.66 26 27
RAP1/GDP 0.079 0.087 0.31 7 -0.4 1 8
adherens junction assembly 0.013 0.039 -10000 0 -0.35 3 3
homophilic cell adhesion 0 0 -10000 0 -10000 0 0
ABI1 0.026 0.02 -10000 0 -0.44 1 1
PIP5K1C 0.025 0.02 -10000 0 -0.44 1 1
regulation of heterotypic cell-cell adhesion 0.041 0.055 -10000 0 -0.22 18 18
E-cadherin/beta catenin 0.011 0.02 -10000 0 -0.3 2 2
mol:GTP 0 0 -10000 0 -10000 0 0
SRC 0.008 0.031 -10000 0 -0.38 2 2
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
Rac1/GTP -0.011 0.083 -10000 0 -0.38 23 23
E-cadherin/beta catenin/alpha catenin 0.051 0.026 -10000 0 -0.27 3 3
ITGAE 0.022 0.011 -10000 0 -10000 0 0
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.025 0.04 -10000 0 -0.37 3 3
BARD1 signaling events

Figure S114.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S114.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BARD1/CSTF1 0.021 0.032 -10000 0 -0.32 3 3
ATM 0.019 0.056 -10000 0 -0.44 8 8
UBE2D3 0.026 0.005 -10000 0 -10000 0 0
PRKDC 0.022 0.022 -10000 0 -0.44 1 1
ATR 0.025 0.028 -10000 0 -0.44 2 2
UBE2L3 0.026 0.005 -10000 0 -10000 0 0
FANCD2 0.012 0.054 -10000 0 -0.38 9 9
protein ubiquitination 0.058 0.058 -10000 0 -0.26 15 15
XRCC5 0.026 0.02 -10000 0 -0.44 1 1
XRCC6 0.025 0.006 -10000 0 -10000 0 0
M/R/N Complex 0.032 0.076 -10000 0 -0.35 18 18
MRE11A 0.019 0.056 -10000 0 -0.44 8 8
DNA-PK 0.044 0.031 -10000 0 -0.5 1 1
FA complex/FANCD2/Ubiquitin 0.016 0.064 -10000 0 -0.46 6 6
FANCF 0.021 0.048 -10000 0 -0.44 6 6
BRCA1 0.025 0.02 -10000 0 -0.44 1 1
CCNE1 0.026 0.004 -10000 0 -10000 0 0
CDK2/Cyclin E1 0.038 0.017 -10000 0 -0.32 1 1
FANCG 0.026 0.004 -10000 0 -10000 0 0
BRCA1/BACH1/BARD1 0.034 0.043 -10000 0 -0.32 8 8
FANCE 0.026 0.003 -10000 0 -10000 0 0
FANCC 0.026 0.003 -10000 0 -10000 0 0
NBN 0.01 0.076 -10000 0 -0.44 15 15
FANCA 0.026 0.004 -10000 0 -10000 0 0
DNA repair 0.026 0.085 0.27 6 -0.46 5 11
BRCA1/BARD1/ubiquitin 0.034 0.043 -10000 0 -0.32 8 8
BARD1/DNA-PK 0.054 0.045 -10000 0 -0.28 6 6
FANCL 0.024 0.034 -10000 0 -0.44 3 3
mRNA polyadenylation -0.021 0.032 0.32 3 -10000 0 3
BRCA1/BARD1/CTIP/M/R/N Complex -0.001 0.13 -10000 0 -0.48 25 25
BRCA1/BACH1/BARD1/TopBP1 0.047 0.042 -10000 0 -0.27 9 9
BRCA1/BARD1/P53 0.029 0.091 -10000 0 -0.26 41 41
BARD1/CSTF1/BRCA1 0.028 0.036 -10000 0 -0.27 3 3
BRCA1/BACH1 0.025 0.02 -10000 0 -0.44 1 1
BARD1 0.021 0.052 -10000 0 -0.44 7 7
PCNA 0.021 0.011 -10000 0 -10000 0 0
BRCA1/BARD1/UbcH5C 0.047 0.04 -10000 0 -0.27 8 8
BRCA1/BARD1/UbcH7 0.046 0.041 -10000 0 -0.27 8 8
BRCA1/BARD1/RAD51/PCNA 0.047 0.044 -10000 0 -0.24 7 7
BARD1/DNA-PK/P53 0.037 0.082 -10000 0 -0.25 32 32
BRCA1/BARD1/Ubiquitin 0.034 0.043 -10000 0 -0.32 8 8
BRCA1/BARD1/CTIP 0.02 0.073 -10000 0 -0.31 21 21
FA complex 0.02 0.045 -10000 0 -0.49 2 2
BARD1/EWS 0.033 0.04 -10000 0 -0.32 7 7
RBBP8 -0.018 0.061 -10000 0 -0.4 13 13
TP53 -0.007 0.11 -10000 0 -0.44 34 34
TOPBP1 0.026 0.02 -10000 0 -0.44 1 1
G1/S transition of mitotic cell cycle -0.028 0.09 0.26 41 -10000 0 41
BRCA1/BARD1 0.065 0.06 -10000 0 -0.27 15 15
CSTF1 0.015 0.013 -10000 0 -10000 0 0
BARD1/EWS-Fli1 0.016 0.037 -10000 0 -0.32 7 7
CDK2 0.026 0.02 -10000 0 -0.44 1 1
UniProt:Q9BZD1 0 0 -10000 0 -10000 0 0
RAD51 0.025 0.007 -10000 0 -10000 0 0
RAD50 0.025 0.02 -10000 0 -0.44 1 1
BRCA1/BARD1/DNA-directed RNA polymerase II holoenzyme 0.034 0.043 -10000 0 -0.32 8 8
EWSR1 0.025 0.006 -10000 0 -10000 0 0
Signaling events mediated by HDAC Class I

Figure S115.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S115.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NF kappa B/RelA 0.041 0.082 -10000 0 -0.3 22 22
Ran/GTP/Exportin 1/HDAC1 -0.022 0.055 -10000 0 -0.3 19 19
NF kappa B1 p50/RelA/I kappa B alpha 0.015 0.082 -10000 0 -0.31 22 22
SUMO1 0.011 0.085 -10000 0 -0.44 19 19
ZFPM1 0.024 0.041 -10000 0 -0.44 4 4
NPC/RanGAP1/SUMO1/Ubc9 -0.004 0.081 -10000 0 -0.36 24 24
FKBP3 0.016 0.065 -10000 0 -0.44 11 11
Histones 0.051 0.051 -10000 0 -10000 0 0
YY1/LSF 0.006 0.075 -10000 0 -0.26 30 30
SMG5 0.025 0.02 -10000 0 -0.44 1 1
RAN 0.026 0.003 -10000 0 -10000 0 0
I kappa B alpha/HDAC3 0.013 0.047 -10000 0 -0.23 19 19
I kappa B alpha/HDAC1 0.016 0.059 -10000 0 -0.37 1 1
SAP18 0.021 0.011 -10000 0 -10000 0 0
RELA 0.011 0.056 -10000 0 -0.56 2 2
HDAC1/Smad7 0.037 0.031 -10000 0 -0.27 2 2
RANGAP1 0.025 0.021 -10000 0 -0.44 1 1
HDAC3/TR2 0.025 0.047 -10000 0 -0.23 1 1
NuRD/MBD3 Complex 0.008 0.056 -10000 0 -0.3 7 7
NF kappa B1 p50/RelA 0.015 0.079 0.3 1 -0.34 11 12
EntrezGene:23225 0 0 -10000 0 -10000 0 0
GATA2 0.011 0.086 -10000 0 -0.44 19 19
GATA1 0.011 0.031 -10000 0 -0.44 1 1
Mad/Max 0.037 0.018 -10000 0 -0.32 1 1
NuRD/MBD3 Complex/GATA1/Fog1 0.002 0.079 -10000 0 -0.41 8 8
RBBP7 0.025 0.02 -10000 0 -0.44 1 1
NPC 0.008 0.042 -10000 0 -0.22 18 18
RBBP4 0.025 0.02 -10000 0 -0.44 1 1
MAX 0.025 0.007 -10000 0 -10000 0 0
EntrezGene:9972 0 0 -10000 0 -10000 0 0
FBXW11 0.026 0.004 -10000 0 -10000 0 0
NFKBIA 0.012 0.038 -10000 0 -0.4 1 1
KAT2B 0.013 0.078 -10000 0 -0.44 16 16
mol:GTP 0 0 -10000 0 -10000 0 0
SIN3/HDAC complex 0.009 0.038 -10000 0 -0.36 1 1
SIN3 complex 0.046 0.04 -10000 0 -0.25 4 4
SMURF1 0.025 0.006 -10000 0 -10000 0 0
CHD3 0.022 0.01 -10000 0 -10000 0 0
SAP30 0.024 0.029 -10000 0 -0.44 2 2
EntrezGene:23636 0 0 -10000 0 -10000 0 0
NCOR1 0.022 0.01 -10000 0 -10000 0 0
YY1/HDAC3 0.003 0.066 -10000 0 -0.34 6 6
YY1/HDAC2 0.007 0.071 -10000 0 -0.26 26 26
YY1/HDAC1 0.007 0.072 -10000 0 -0.25 28 28
NuRD/MBD2 Complex (MeCP1) 0.001 0.068 -10000 0 -0.29 17 17
PPARG 0.003 0.078 -10000 0 -0.32 27 27
HDAC8/hEST1B 0.052 0.017 -10000 0 -0.27 1 1
UBE2I 0.026 0.004 -10000 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.026 0.004 -10000 0 -10000 0 0
TNFRSF1A 0.026 0.005 -10000 0 -10000 0 0
HDAC3/SMRT (N-CoR2) 0.025 0.05 -10000 0 -0.23 3 3
MBD3L2 -0.017 0.007 -10000 0 -10000 0 0
ubiquitin-dependent protein catabolic process 0.037 0.031 -10000 0 -0.27 2 2
CREBBP 0.026 0.004 -10000 0 -10000 0 0
NuRD/MBD3/MBD3L2 Complex 0.004 0.074 -10000 0 -0.34 8 8
HDAC1 0.026 0.005 -10000 0 -10000 0 0
HDAC3 0.014 0.035 -10000 0 -10000 0 0
HDAC2 0.026 0.005 -10000 0 -10000 0 0
YY1 0.006 0.056 -10000 0 -0.3 17 17
HDAC8 0.027 0.002 -10000 0 -10000 0 0
SMAD7 0.018 0.03 -10000 0 -0.44 2 2
NCOR2 0.024 0.035 -10000 0 -0.44 3 3
MXD1 0.026 0.021 -10000 0 -0.44 1 1
STAT3 0.017 0.019 -10000 0 -0.29 2 2
NFKB1 0.025 0.02 -10000 0 -0.44 1 1
EntrezGene:8021 0 0 -10000 0 -10000 0 0
RANBP2 0.012 0.083 -10000 0 -0.44 18 18
YY1/LSF/HDAC1 0.019 0.075 -10000 0 -0.26 22 22
YY1/SAP30/HDAC1 0.019 0.073 -10000 0 -0.24 26 26
EP300 0.024 0.029 -10000 0 -0.44 2 2
STAT3 (dimer non-phopshorylated) 0.017 0.019 -10000 0 -0.29 2 2
proteasomal ubiquitin-dependent protein catabolic process 0.012 0.038 -10000 0 -0.4 1 1
histone deacetylation 0.001 0.067 -10000 0 -0.29 17 17
STAT3 (dimer non-phopshorylated)/HDAC3 0.017 0.041 -10000 0 -10000 0 0
nuclear export -0.051 0.017 0.27 1 -10000 0 1
PRKACA 0.026 0.003 -10000 0 -10000 0 0
GATAD2B 0.026 0.004 -10000 0 -10000 0 0
GATAD2A 0.026 0.02 -10000 0 -0.44 1 1
GATA2/HDAC3 0.017 0.067 -10000 0 -0.24 19 19
GATA1/HDAC1 0.036 0.019 -10000 0 -0.32 1 1
GATA1/HDAC3 0.025 0.048 -10000 0 -0.23 1 1
CHD4 0.026 0.005 -10000 0 -10000 0 0
TNF-alpha/TNFR1A 0.027 0.065 -10000 0 -0.32 19 19
SIN3/HDAC complex/Mad/Max 0.024 0.056 -10000 0 -0.28 6 6
NuRD Complex -0.018 0.097 -10000 0 -0.32 23 23
positive regulation of chromatin silencing 0.049 0.05 -10000 0 -10000 0 0
SIN3B 0.026 0.02 -10000 0 -0.44 1 1
MTA2 0.026 0.004 -10000 0 -10000 0 0
SIN3A 0.025 0.021 -10000 0 -0.44 1 1
XPO1 0.017 0.065 -10000 0 -0.44 11 11
SUMO1/HDAC1 0.017 0.095 -10000 0 -0.43 21 21
HDAC complex 0.062 0.026 -10000 0 -0.25 2 2
GATA1/Fog1 0.035 0.036 -10000 0 -0.32 5 5
FKBP25/HDAC1/HDAC2 0.041 0.048 -10000 0 -0.27 11 11
TNF 0.011 0.086 -10000 0 -0.44 19 19
negative regulation of cell growth 0.024 0.055 -10000 0 -0.27 6 6
NuRD/MBD2/PRMT5 Complex 0.001 0.068 -10000 0 -0.29 17 17
Ran/GTP/Exportin 1 0.016 0.1 -10000 0 -0.42 24 24
NF kappa B/RelA/I kappa B alpha 0.004 0.074 -10000 0 -0.32 21 21
SIN3/HDAC complex/NCoR1 -0.004 0.063 -10000 0 -0.3 11 11
TFCP2 0.025 0.028 -10000 0 -0.44 2 2
NR2C1 0.026 0.02 -10000 0 -0.44 1 1
MBD3 0.024 0.035 -10000 0 -0.44 3 3
MBD2 0.019 0.023 -10000 0 -0.44 1 1
Signaling events mediated by VEGFR1 and VEGFR2

Figure S116.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S116.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
alphaV beta3 Integrin 0.025 0.072 -10000 0 -0.33 21 21
AKT1 0.068 0.11 0.36 13 -0.46 7 20
PTK2B -0.02 0.071 0.34 1 -0.55 5 6
VEGFR2 homodimer/Frs2 0.026 0.059 -10000 0 -0.54 5 5
CAV1 0.024 0.041 -10000 0 -0.44 4 4
CALM1 0.025 0.007 -10000 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/Frs2 0.041 0.061 -10000 0 -0.58 4 4
endothelial cell proliferation 0.095 0.15 0.31 92 -0.42 7 99
mol:Ca2+ 0.003 0.046 -10000 0 -0.51 3 3
VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Rac 0.048 0.062 -10000 0 -0.67 3 3
RP11-342D11.1 -0.01 0.052 -10000 0 -0.47 5 5
CDH5 0.026 0.021 -10000 0 -0.44 1 1
VEGFA homodimer 0.057 0.044 -10000 0 -0.29 6 6
SHC1 0.026 0.004 -10000 0 -10000 0 0
SHC2 0.001 0.11 -10000 0 -0.44 33 33
HRAS/GDP 0.038 0.055 -10000 0 -0.55 3 3
SH2D2A 0.026 0.005 -10000 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/SHP1/eNOS 0.077 0.11 0.3 3 -0.43 12 15
VEGFR2 homodimer/VEGFA homodimer/TsAd 0.041 0.054 -10000 0 -0.63 3 3
VEGFR1 homodimer 0.019 0.023 -10000 0 -0.44 1 1
SHC/GRB2/SOS1 0.062 0.063 -10000 0 -0.6 3 3
GRB10 0.006 0.068 -10000 0 -0.59 6 6
PTPN11 0.022 0.044 -10000 0 -0.44 5 5
GRB2 0.026 0.004 -10000 0 -10000 0 0
PAK1 0.026 0.004 -10000 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Cadherin/beta catenin 0.063 0.063 -10000 0 -0.65 3 3
HRAS 0.026 0.021 -10000 0 -0.44 1 1
VEGF/Rho/ROCK1/Integrin Complex -0.021 0.12 -10000 0 -0.52 17 17
HIF1A 0.02 0.049 -10000 0 -0.44 6 6
FRS2 0.025 0.028 -10000 0 -0.44 2 2
oxygen and reactive oxygen species metabolic process 0.046 0.061 -10000 0 -0.66 3 3
mol:GTP 0 0 -10000 0 -10000 0 0
FLT4 0.021 0.057 -10000 0 -0.44 8 8
Nck/Pak 0.037 0.022 -10000 0 -0.32 2 2
VEGFR2 homodimer/VEGFA homodimer/Fyn 0.039 0.06 -10000 0 -0.57 4 4
mol:GDP 0.049 0.058 -10000 0 -0.58 3 3
mol:NADP 0.066 0.11 0.33 12 -0.41 12 24
eNOS/Hsp90 0.071 0.11 0.32 12 -0.39 12 24
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
mol:IP3 0.003 0.046 -10000 0 -0.51 3 3
HIF1A/ARNT 0.032 0.044 -10000 0 -0.36 6 6
SHB 0.026 0.005 -10000 0 -10000 0 0
VEGFA 0.027 0.009 -10000 0 -10000 0 0
VEGFC 0.014 0.077 -10000 0 -0.44 15 15
FAK1/Vinculin 0.03 0.11 0.3 3 -0.54 10 13
mol:Ca ++ 0 0 -10000 0 -10000 0 0
RHOA 0.025 0.02 -10000 0 -0.44 1 1
VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin 0.045 0.082 -10000 0 -0.57 5 5
PTPN6 0.026 0.004 -10000 0 -10000 0 0
EPAS1 0.029 0.034 -10000 0 -0.36 4 4
mol:L-citrulline 0.066 0.11 0.33 12 -0.41 12 24
ITGAV 0.017 0.065 -10000 0 -0.44 11 11
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
VEGFR2 homodimer/VEGFA homodimer/Frs2/GRB2 0.054 0.061 -10000 0 -0.67 3 3
VEGFR2 homodimer/VEGFA homodimer 0.041 0.063 -10000 0 -0.51 5 5
VEGFR2/3 heterodimer 0.023 0.067 -10000 0 -0.39 11 11
VEGFB 0.026 0.004 -10000 0 -10000 0 0
MAPK11 -0.009 0.07 0.24 1 -0.47 9 10
VEGFR2 homodimer 0.012 0.056 -10000 0 -0.74 3 3
FLT1 0.019 0.023 -10000 0 -0.44 1 1
NEDD4 0.024 0.03 -10000 0 -0.44 2 2
MAPK3 0.039 0.094 0.31 9 -0.48 3 12
MAPK1 0.037 0.092 0.32 7 -0.48 3 10
VEGFA145/NRP2 0.035 0.047 -10000 0 -0.32 9 9
VEGFR1/2 heterodimer 0.02 0.051 -10000 0 -0.46 5 5
KDR 0.012 0.056 -10000 0 -0.74 3 3
VEGFA165/NRP1/VEGFR2 homodimer 0.039 0.069 -10000 0 -0.46 6 6
SRC 0.015 0.023 -10000 0 -0.44 1 1
platelet activating factor biosynthetic process 0.047 0.1 0.32 13 -0.5 3 16
PI3K 0.04 0.082 -10000 0 -0.5 5 5
VEGFR2 homodimer/VEGFA homodimer/NCK1 0.042 0.055 -10000 0 -0.53 4 4
FES 0.005 0.065 -10000 0 -0.59 4 4
GAB1 0.017 0.058 -10000 0 -0.54 4 4
VEGFR2 homodimer/VEGFA homodimer/Src 0.024 0.05 -10000 0 -0.45 4 4
CTNNB1 0.026 0.003 -10000 0 -10000 0 0
SOS1 0.027 0.002 -10000 0 -10000 0 0
ARNT 0.025 0.02 -10000 0 -0.44 1 1
eNOS/Caveolin-1 0.067 0.11 0.3 5 -0.39 12 17
VEGFR2 homodimer/VEGFA homodimer/Yes 0.033 0.062 -10000 0 -0.58 4 4
PI3K/GAB1 0.037 0.076 -10000 0 -0.46 6 6
VEGFR2 homodimer/VEGFA homodimer/Frs2/Nck/Pak 0.064 0.064 -10000 0 -0.6 4 4
PRKACA 0.026 0.003 -10000 0 -10000 0 0
VEGFR2/3 heterodimer/VEGFC homodimer 0.03 0.083 -10000 0 -0.33 23 23
HSP90AA1 0.024 0.021 -10000 0 -0.44 1 1
CDC42 0.008 0.062 -10000 0 -0.7 3 3
actin cytoskeleton reorganization 0.041 0.054 -10000 0 -0.62 3 3
PTK2 0.01 0.099 0.24 2 -0.51 12 14
EDG1 -0.01 0.052 -10000 0 -0.47 5 5
mol:DAG 0.003 0.046 -10000 0 -0.51 3 3
CaM/Ca2+ 0.012 0.047 -10000 0 -0.47 3 3
MAP2K3 -0.013 0.057 -10000 0 -0.56 4 4
VEGFR2 homodimer/VEGFA homodimer/GRB10/NEDD4 0.05 0.089 -10000 0 -0.61 6 6
PLCG1 0.003 0.047 -10000 0 -0.52 3 3
VEGFR2 homodimer/VEGFA homodimer/Src/Shb 0.031 0.053 -10000 0 -0.49 3 3
IQGAP1 0.024 0.029 -10000 0 -0.44 2 2
YES1 0.019 0.035 -10000 0 -0.44 3 3
VEGFR2 homodimer/VEGFA homodimer/SHP2 0.04 0.063 -10000 0 -0.47 6 6
VEGFR2 homodimer/VEGFA homodimer/SHP1 0.041 0.054 -10000 0 -0.63 3 3
cell migration 0.035 0.11 0.29 6 -0.52 8 14
mol:PI-3-4-5-P3 0.039 0.077 -10000 0 -0.46 5 5
FYN 0.023 0.04 -10000 0 -0.44 4 4
VEGFB/NRP1 0.015 0.053 -10000 0 -0.58 3 3
mol:NO 0.066 0.11 0.33 12 -0.41 12 24
PXN 0.027 0.002 -10000 0 -10000 0 0
HRAS/GTP 0.02 0.051 -10000 0 -0.55 3 3
VEGFR2 homodimer/VEGFA homodimer/GRB10 0.026 0.073 -10000 0 -0.61 6 6
VHL 0.025 0.02 -10000 0 -0.44 1 1
ITGB3 0.018 0.066 -10000 0 -0.44 11 11
NOS3 0.067 0.12 0.34 12 -0.46 12 24
VEGFR2 homodimer/VEGFA homodimer/Sck 0.027 0.086 -10000 0 -0.28 33 33
RAC1 0.024 0.008 -10000 0 -10000 0 0
PRKCA -0.009 0.042 -10000 0 -0.49 3 3
PRKCB -0.016 0.06 -10000 0 -0.43 5 5
VCL 0.024 0.028 -10000 0 -0.44 2 2
VEGFA165/NRP1 0.018 0.055 -10000 0 -0.47 5 5
VEGFR1/2 heterodimer/VEGFA homodimer 0.031 0.053 -10000 0 -0.49 4 4
VEGFA165/NRP2 0.035 0.047 -10000 0 -0.32 9 9
MAPKKK cascade 0.017 0.066 -10000 0 -0.52 6 6
NRP2 0.021 0.061 -10000 0 -0.44 9 9
VEGFC homodimer 0.014 0.076 -10000 0 -0.44 15 15
NCK1 0.025 0.028 -10000 0 -0.44 2 2
ROCK1 0.017 0.049 -10000 0 -0.44 6 6
FAK1/Paxillin 0.031 0.11 0.3 3 -0.53 9 12
MAP3K13 0.009 0.059 -10000 0 -0.58 4 4
PDPK1 0.062 0.1 0.24 76 -0.42 5 81
Signaling events mediated by HDAC Class II

Figure S117.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S117.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
G beta1gamma2/HDAC5 0.056 0.044 -10000 0 -0.29 6 6
HDAC3 0.026 0.004 -10000 0 -10000 0 0
Ran/GTP/Exportin 1/HDAC4 -0.023 0.055 -10000 0 -0.3 19 19
GATA1/HDAC4 0.037 0.018 -10000 0 -0.32 1 1
GATA1/HDAC5 0.036 0.024 -10000 0 -0.32 2 2
GATA2/HDAC5 0.026 0.068 -10000 0 -0.33 19 19
HDAC5/BCL6/BCoR 0.051 0.018 -10000 0 -0.27 1 1
HDAC9 0 0.11 -10000 0 -0.44 31 31
Glucocorticoid receptor/Hsp90/HDAC6 0.04 0.059 -10000 0 -0.27 18 18
HDAC4/ANKRA2 0.038 0.017 -10000 0 -0.32 1 1
HDAC5/YWHAB 0.021 0.024 -10000 0 -0.32 1 1
NPC/RanGAP1/SUMO1/Ubc9 -0.004 0.081 -10000 0 -0.36 24 24
GATA2 0.011 0.086 -10000 0 -0.44 19 19
HDAC4/RFXANK 0.038 0.022 -10000 0 -0.32 2 2
BCOR 0.026 0.003 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
HDAC10 0.024 0.029 -10000 0 -0.44 2 2
HDAC5 0.025 0.02 -10000 0 -0.44 1 1
GNB1/GNG2 0.032 0.036 -10000 0 -0.32 5 5
Histones 0.009 0.084 -10000 0 -0.37 13 13
ADRBK1 0.026 0.021 -10000 0 -0.44 1 1
HDAC4 0.027 0.004 -10000 0 -10000 0 0
XPO1 0.017 0.065 -10000 0 -0.44 11 11
HDAC5/ANKRA2 0.036 0.023 -10000 0 -0.32 2 2
HDAC4/Ubc9 0.039 0.007 -10000 0 -10000 0 0
HDAC7 0.026 0.02 -10000 0 -0.44 1 1
HDAC5/14-3-3 E 0.032 0.022 -10000 0 -0.32 1 1
TUBA1B 0.027 0.002 -10000 0 -10000 0 0
HDAC6 0.026 0.003 -10000 0 -10000 0 0
HDAC5/RFXANK 0.037 0.031 -10000 0 -0.45 2 2
CAMK4 0.013 0.077 -10000 0 -0.44 15 15
Tubulin/HDAC6 0.049 0.044 -10000 0 -0.27 9 9
SUMO1 0.011 0.085 -10000 0 -0.44 19 19
EntrezGene:9972 0 0 -10000 0 -10000 0 0
YWHAB 0.015 0.013 -10000 0 -10000 0 0
GATA1 0.011 0.031 -10000 0 -0.44 1 1
EntrezGene:8021 0 0 -10000 0 -10000 0 0
YWHAE 0.022 0.01 -10000 0 -10000 0 0
NR3C1 0.013 0.081 -10000 0 -0.44 17 17
SUMO1/HDAC4 0.017 0.096 -10000 0 -0.42 22 22
SRF 0.026 0.005 -10000 0 -10000 0 0
HDAC4/YWHAB 0.022 0.02 -10000 0 -10000 0 0
Tubulin 0.035 0.047 -10000 0 -0.32 9 9
HDAC4/14-3-3 E 0.033 0.016 -10000 0 -10000 0 0
GNB1 0.025 0.006 -10000 0 -10000 0 0
RANGAP1 0.025 0.021 -10000 0 -0.44 1 1
BCL6/BCoR 0.039 0.007 -10000 0 -10000 0 0
HDAC4/HDAC3/SMRT (N-CoR2) 0.051 0.026 -10000 0 -0.27 3 3
HDAC4/SRF 0.042 0.055 -10000 0 -0.28 15 15
HDAC4/ER alpha 0.023 0.078 -10000 0 -0.32 27 27
EntrezGene:23225 0 0 -10000 0 -10000 0 0
positive regulation of chromatin silencing 0.009 0.083 -10000 0 -0.35 14 14
cell motility 0.048 0.043 -10000 0 -0.27 9 9
EntrezGene:23636 0 0 -10000 0 -10000 0 0
UBE2I 0.026 0.004 -10000 0 -10000 0 0
HDAC7/HDAC3 0.038 0.016 -10000 0 -0.32 1 1
BCL6 0.027 0.007 -10000 0 -10000 0 0
HDAC4/CaMK II delta B 0.027 0.004 -10000 0 -10000 0 0
Hsp90/HDAC6 0.036 0.018 -10000 0 -0.32 1 1
ESR1 0.004 0.1 -10000 0 -0.44 27 27
HDAC6/HDAC11 0.037 0.022 -10000 0 -0.32 2 2
Ran/GTP/Exportin 1 0.016 0.1 -10000 0 -0.42 24 24
NPC 0.008 0.042 -10000 0 -0.22 18 18
MEF2C 0.022 0.045 -10000 0 -0.44 5 5
RAN 0.026 0.003 -10000 0 -10000 0 0
HDAC4/MEF2C 0.07 0.043 -10000 0 -0.24 8 8
GNG2 0.021 0.045 -10000 0 -0.44 5 5
NCOR2 0.024 0.035 -10000 0 -0.44 3 3
TUBB2A 0.022 0.061 -10000 0 -0.44 9 9
HDAC11 0.025 0.028 -10000 0 -0.44 2 2
HSP90AA1 0.024 0.021 -10000 0 -0.44 1 1
RANBP2 0.012 0.083 -10000 0 -0.44 18 18
ANKRA2 0.025 0.02 -10000 0 -0.44 1 1
RFXANK 0.025 0.028 -10000 0 -0.44 2 2
nuclear import -0.016 0.021 0.27 1 -10000 0 1
Canonical NF-kappaB pathway

Figure S118.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S118.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
FBXW11 0.028 0.004 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
NF kappa B1 p50/RelA/I kappa B alpha 0.031 0.09 0.31 8 -0.31 7 15
ERC1 0.026 0.006 -10000 0 -10000 0 0
RIP2/NOD2 0.024 0.06 -10000 0 -0.32 16 16
NFKBIA -0.009 0.012 -10000 0 -0.24 1 1
BIRC2 0.015 0.071 -10000 0 -0.44 13 13
IKBKB 0.023 0.009 -10000 0 -10000 0 0
RIPK2 0.023 0.009 -10000 0 -10000 0 0
IKBKG 0.01 0.067 -10000 0 -0.39 6 6
IKK complex/A20 0.031 0.087 -10000 0 -0.37 8 8
NEMO/A20/RIP2 0.023 0.009 -10000 0 -10000 0 0
XPO1 0.017 0.065 -10000 0 -0.44 11 11
NEMO/ATM 0.026 0.086 0.26 2 -0.4 12 14
tumor necrosis factor receptor activity 0 0 -10000 0 -10000 0 0
RAN 0.026 0.003 -10000 0 -10000 0 0
Exportin 1/RanGTP 0.03 0.042 -10000 0 -0.27 11 11
IKK complex/ELKS 0.028 0.074 -10000 0 -0.4 7 7
BCL10/MALT1/TRAF6 0.036 0.048 -10000 0 -0.36 5 5
NOD2 0.011 0.085 -10000 0 -0.44 19 19
NFKB1 0.026 0.02 -10000 0 -0.44 1 1
RELA 0.028 0.004 -10000 0 -10000 0 0
MALT1 0.018 0.03 -10000 0 -0.44 2 2
cIAP1/UbcH5C 0.029 0.054 -10000 0 -0.32 13 13
ATM 0.019 0.056 -10000 0 -0.44 8 8
TNF/TNFR1A 0.027 0.065 -10000 0 -0.32 19 19
TRAF6 0.025 0.02 -10000 0 -0.44 1 1
PRKCA 0.025 0.02 -10000 0 -0.44 1 1
CHUK 0.023 0.035 -10000 0 -0.44 3 3
UBE2D3 0.026 0.005 -10000 0 -10000 0 0
TNF 0.011 0.086 -10000 0 -0.44 19 19
NF kappa B1 p50/RelA 0.056 0.02 -10000 0 -0.27 1 1
BCL10 0.023 0.04 -10000 0 -0.44 4 4
proteasomal ubiquitin-dependent protein catabolic process -0.009 0.012 -10000 0 -0.24 1 1
beta TrCP1/SCF ubiquitin ligase complex 0.028 0.004 -10000 0 -10000 0 0
TNFRSF1A 0.026 0.005 -10000 0 -10000 0 0
IKK complex 0.029 0.079 -10000 0 -0.42 7 7
CYLD 0.025 0.02 -10000 0 -0.44 1 1
IKK complex/PKC alpha 0.036 0.081 -10000 0 -0.41 7 7
p38 MAPK signaling pathway

Figure S119.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S119.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TRAF6/ASK1 0.018 0.024 -10000 0 -0.33 2 2
TRAF2/ASK1 0.034 0.02 -10000 0 -0.27 2 2
ATM 0.019 0.056 -10000 0 -0.44 8 8
MAP2K3 -0.008 0.11 0.36 2 -0.43 25 27
response to stress 0 0 -10000 0 -10000 0 0
MAP2K6 -0.003 0.1 0.28 4 -0.41 20 24
hyperosmotic response 0 0 -10000 0 -10000 0 0
response to oxidative stress 0 0 -10000 0 -10000 0 0
GADD45G 0.028 0.024 -10000 0 -0.44 1 1
TXN 0.006 0.001 -10000 0 -10000 0 0
CALM1 0.025 0.007 -10000 0 -10000 0 0
GADD45A 0.024 0.028 -10000 0 -0.44 2 2
GADD45B 0.027 0.007 -10000 0 -10000 0 0
MAP3K1 0.022 0.044 -10000 0 -0.44 5 5
MAP3K6 0.022 0.04 -10000 0 -0.44 4 4
MAP3K7 0.026 0.004 -10000 0 -10000 0 0
MAP3K4 0.026 0.004 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
ASK1/ASK2 0.033 0.038 -10000 0 -0.32 6 6
TAK1/TAB family 0.001 0.019 0.16 3 -0.13 1 4
RAC1/OSM/MEKK3 0.043 0.028 -10000 0 -0.26 3 3
TRAF2 0.025 0.02 -10000 0 -0.44 1 1
RAC1/OSM/MEKK3/MKK3 0.007 0.093 -10000 0 -0.37 21 21
TRAF6 0.006 0.013 -10000 0 -0.3 1 1
RAC1 0.024 0.008 -10000 0 -10000 0 0
mol:LPS 0 0 -10000 0 -10000 0 0
CAMK2B 0.007 0.091 -10000 0 -0.44 20 20
CCM2 0.024 0.021 -10000 0 -0.44 1 1
CaM/Ca2+/CAMKIIB 0.023 0.059 -10000 0 -0.27 20 20
MAPK11 0.024 0.037 -10000 0 -0.44 3 3
response to DNA damage stimulus 0 0 -10000 0 -10000 0 0
CaM/Ca2+/CAMKIIB/ASK1 0.034 0.061 -10000 0 -0.25 22 22
OSM/MEKK3 0.033 0.03 -10000 0 -0.33 3 3
TAOK1 0.003 0.064 -10000 0 -0.38 13 13
TAOK2 0.007 0.039 -10000 0 -0.3 9 9
TAOK3 0.008 0.037 -10000 0 -0.3 8 8
MAP3K7IP1 0 0 -10000 0 -10000 0 0
MAPK14 0.026 0.003 -10000 0 -10000 0 0
MAP3K7IP2 0 0 -10000 0 -10000 0 0
MAP3K5 0.024 0.028 -10000 0 -0.44 2 2
MAP3K10 0.024 0.035 -10000 0 -0.44 3 3
MAP3K3 0.024 0.028 -10000 0 -0.44 2 2
TRX/ASK1 0.023 0.015 -10000 0 -0.26 1 1
GADD45/MTK1/MTK1 0.058 0.029 -10000 0 -0.25 3 3
Arf1 pathway

Figure S120.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S120.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
coatomer protein complex 0.057 0.072 0.15 171 -0.5 1 172
EntrezGene:79658 0 0 -10000 0 -10000 0 0
ARF1/GDP/Membrin/GBF1/p115/Brefeldin A 0.006 0.04 0.15 10 -0.18 6 16
AP2 0.038 0.017 -10000 0 -0.32 1 1
mol:DAG 0 0 -10000 0 -10000 0 0
Arfaptin 2/Rac/GTP 0.031 0.013 -10000 0 -10000 0 0
CLTB 0.026 0.021 -10000 0 -0.44 1 1
coatomer protein complex/ARF1/GTP/ER cargo protein 0.017 0.011 -10000 0 -0.22 1 1
CD4 0.01 0.088 -10000 0 -0.44 20 20
CLTA 0.026 0.004 -10000 0 -10000 0 0
mol:GTP -0.001 0.003 -10000 0 -10000 0 0
ARFGAP1 -0.004 0.013 -10000 0 -0.32 1 1
mol:PI-4-5-P2 0.004 0.019 -10000 0 -0.28 2 2
ARF1/GTP 0.034 0.014 -10000 0 -10000 0 0
coatomer protein complex/ARF1/GTP/ARF-GAP1/ER cargo protein 0.005 0.02 0.18 2 -0.38 1 3
mol:Choline 0.003 0.018 -10000 0 -0.28 2 2
mol:GDP 0 0 -10000 0 -10000 0 0
ARF1 0.027 0.007 -10000 0 -10000 0 0
DDEF1 0.002 0.019 -10000 0 -0.29 2 2
ARF1/GDP 0.001 0.014 -10000 0 -0.26 1 1
AP2M1 0.027 0.002 -10000 0 -10000 0 0
EntrezGene:1313 0 0 -10000 0 -10000 0 0
actin filament polymerization 0.01 0.006 -10000 0 -10000 0 0
Rac/GTP 0.019 0.007 -10000 0 -10000 0 0
ARF1/GTP/GGA3/ARF-GAP1 0.021 0.023 -10000 0 -0.24 1 1
ARFIP2 0.016 0.022 -10000 0 -10000 0 0
COPA 0.026 0.004 -10000 0 -10000 0 0
RAC1 0.024 0.008 -10000 0 -10000 0 0
ARF1/GTP/coatomer protein complex 0.011 0.019 0.14 1 -0.18 1 2
ARF1/GTP/ARHGAP10 0.019 0.006 -10000 0 -10000 0 0
GGA3 0.026 0.004 -10000 0 -10000 0 0
ARF1/GTP/Membrin 0.022 0.032 -10000 0 -0.24 7 7
AP2A1 0.026 0.021 -10000 0 -0.44 1 1
coatomer protein complex/ARF1/GTP/ARF-GAP1 0.006 0.029 0.13 2 -0.36 2 4
ARF1/GDP/Membrin 0.015 0.039 -10000 0 -0.26 8 8
Arfaptin 2/Rac/GDP 0.03 0.013 -10000 0 -10000 0 0
CYTH2 0.028 0.006 -10000 0 -10000 0 0
ARF1/GTP/GGA3 0.036 0.01 -10000 0 -10000 0 0
mol:ATP 0 0 -10000 0 -10000 0 0
Rac/GDP 0.018 0.006 -10000 0 -10000 0 0
mol:Brefeldin A 0 0 -10000 0 -10000 0 0
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex/Coatomer protein complex/ARF1/GTP 0.012 0.044 -10000 0 -0.2 20 20
PLD2 0.003 0.019 -10000 0 -0.28 2 2
ARF-GAP1/v-SNARE -0.004 0.013 -10000 0 -0.32 1 1
PIP5K1A 0.004 0.019 -10000 0 -0.29 2 2
ARF1/GTP/Membrin/GBF1/p115 0.008 0.033 -10000 0 -0.15 6 6
mol:Phosphatic acid 0 0 -10000 0 -10000 0 0
mol:Phosphatidic acid 0.003 0.018 -10000 0 -0.28 2 2
KDEL Receptor/Ligand/ARF-GAP1 -0.004 0.013 -10000 0 -0.32 1 1
GOSR2 0.009 0.017 -10000 0 -0.31 1 1
USO1 0.003 0.057 -10000 0 -0.41 10 10
GBF1 0.005 0.041 -10000 0 -0.32 8 8
ARF1/GTP/Arfaptin 2 0.036 0.01 -10000 0 -10000 0 0
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex 0.04 0.063 -10000 0 -0.27 21 21
Aurora C signaling

Figure S121.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S121.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
INCENP 0.026 0.004 -9999 0 -10000 0 0
Aurora C/Aurora B/INCENP 0.033 0.052 -9999 0 -0.24 16 16
metaphase 0 0 -9999 0 -10000 0 0
mitosis 0 0 -9999 0 -10000 0 0
H3F3B 0.007 0.02 -9999 0 -0.3 1 1
AURKB 0.022 0.01 -9999 0 -10000 0 0
AURKC 0.012 0.079 -9999 0 -0.44 16 16
PLK2 and PLK4 events

Figure S122.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S122.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PLK2 0.025 0.037 -9999 0 -0.44 3 3
PLK4 0.024 0.028 -9999 0 -0.44 2 2
regulation of centriole replication -0.015 0.034 -9999 0 -0.38 4 4
Atypical NF-kappaB pathway

Figure S123.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S123.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL3/RelA 0.037 0.023 -10000 0 -0.32 2 2
FBXW11 0.026 0.004 -10000 0 -10000 0 0
NF kappa B1 p50/c-Rel 0.021 0.027 -10000 0 -0.27 4 4
NF kappa B1 p50/RelA/I kappa B alpha 0.045 0.059 0.2 4 -0.21 4 8
NFKBIA 0.041 0.057 -10000 0 -0.2 6 6
MAPK14 0.026 0.003 -10000 0 -10000 0 0
NF kappa B1 p105/p50 0.023 0.016 -10000 0 -0.27 1 1
ARRB2 0.011 0.005 -10000 0 -10000 0 0
REL 0.024 0.034 -10000 0 -0.44 3 3
response to oxidative stress 0 0 -10000 0 -10000 0 0
BCL3/NF kappa B1 p50 0.022 0.024 -10000 0 -0.27 3 3
response to UV 0 0 -10000 0 -10000 0 0
NF kappa B1 p105/RelA 0.023 0.016 -10000 0 -0.27 1 1
PIK3CA 0.025 0.028 -10000 0 -0.44 2 2
NF kappa B1 p50 dimer 0.016 0.016 -10000 0 -0.32 1 1
PIK3R1 0.024 0.028 -10000 0 -0.44 2 2
NFKB1 -0.01 0.017 0.23 1 -0.32 1 2
RELA 0.026 0.004 -10000 0 -10000 0 0
positive regulation of anti-apoptosis 0.03 0.051 -10000 0 -0.2 6 6
NF kappa B1 p50/RelA/I kappa B alpha/beta Arrestin2 0.038 0.059 0.19 4 -0.21 5 9
SRC 0.015 0.023 -10000 0 -0.44 1 1
PI3K 0.035 0.031 -10000 0 -0.32 4 4
NF kappa B1 p50/RelA 0.03 0.051 -10000 0 -0.2 6 6
IKBKB 0.023 0.009 -10000 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.026 0.004 -10000 0 -10000 0 0
SYK 0.026 0.004 -10000 0 -10000 0 0
I kappa B alpha/PIK3R1 0.048 0.064 0.21 4 -0.2 8 12
cell death 0.036 0.057 0.19 4 -0.21 5 9
NF kappa B1 p105/c-Rel 0.021 0.027 -10000 0 -0.27 4 4
LCK 0.014 0.085 -10000 0 -0.44 18 18
BCL3 0.025 0.028 -10000 0 -0.44 2 2
Rapid glucocorticoid signaling

Figure S124.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S124.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Gs family/GDP/Gbeta gamma 0.031 0.049 -10000 0 -0.23 15 15
MAPK9 0.006 0.001 -10000 0 -10000 0 0
adrenocorticotropin secretion -0.01 0.005 -10000 0 -10000 0 0
GNB1/GNG2 0.03 0.031 -10000 0 -0.27 5 5
GNB1 0.025 0.006 -10000 0 -10000 0 0
regulation of calcium ion transport via voltage-gated calcium channel activity 0 0 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
MAPK14 0.006 0.001 -10000 0 -10000 0 0
Gs family/GTP 0.01 0.036 -10000 0 -0.19 14 14
EntrezGene:2778 0 0 -10000 0 -10000 0 0
vasopressin secretion 0 0 -10000 0 -10000 0 0
G-protein coupled receptor activity 0 0 -10000 0 -10000 0 0
ChemicalAbstracts:86-01-1 0 0 -10000 0 -10000 0 0
glutamate secretion 0.003 0.009 0.061 11 -10000 0 11
GNAL 0.015 0.065 -10000 0 -0.44 10 10
GNG2 0.021 0.045 -10000 0 -0.44 5 5
CRH -0.015 0.01 -10000 0 -10000 0 0
mol:cortisol 0 0 -10000 0 -10000 0 0
MAPK8 0.006 0.013 -10000 0 -0.3 1 1
MAPK11 0.005 0.022 -10000 0 -0.3 3 3
E-cadherin signaling in keratinocytes

Figure S125.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S125.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
keratinocyte differentiation 0.003 0.041 -10000 0 -0.4 3 3
adherens junction organization 0.028 0.047 -10000 0 -0.31 2 2
mol:GTP 0 0 -10000 0 -10000 0 0
Rac1/GDP 0.01 0.039 -10000 0 -0.35 3 3
FMN1 0.028 0.043 -10000 0 -0.31 2 2
mol:IP3 0.006 0.03 -10000 0 -0.24 5 5
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin 0.037 0.043 -10000 0 -0.32 2 2
CTNNB1 0.027 0.003 -10000 0 -10000 0 0
AKT1 0.044 0.059 0.18 7 -0.38 2 9
E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin 0.061 0.07 -10000 0 -0.48 3 3
CTNND1 0.029 0.006 -10000 0 -10000 0 0
mol:PI-4-5-P2 0.031 0.045 -10000 0 -0.28 4 4
VASP 0.03 0.041 -10000 0 -0.31 2 2
ZYX 0.029 0.045 -10000 0 -0.4 2 2
JUB 0.033 0.041 -10000 0 -0.3 2 2
EGFR(dimer) 0.042 0.053 -10000 0 -0.27 5 5
E-cadherin/beta catenin-gamma catenin 0.048 0.022 -10000 0 -0.26 2 2
mol:PI-3-4-5-P3 0.078 0.07 0.21 8 -0.24 5 13
PIK3CA 0.028 0.029 -10000 0 -0.44 2 2
PI3K 0.08 0.072 0.22 8 -0.24 5 13
FYN -0.001 0.039 -10000 0 -0.28 7 7
mol:Ca2+ 0.006 0.029 -10000 0 -0.24 5 5
JUP 0.026 0.021 -10000 0 -0.45 1 1
PIK3R1 0.027 0.029 -10000 0 -0.44 2 2
mol:DAG 0.006 0.03 -10000 0 -0.24 5 5
CDH1 0.026 0.02 -10000 0 -0.44 1 1
RhoA/GDP 0.013 0.046 -10000 0 -0.33 4 4
establishment of polarity of embryonic epithelium 0.032 0.042 -10000 0 -0.3 2 2
SRC 0.015 0.023 -10000 0 -0.44 1 1
RAC1 0.024 0.008 -10000 0 -10000 0 0
RHOA 0.025 0.02 -10000 0 -0.44 1 1
EGFR 0.02 0.045 -10000 0 -0.44 5 5
CASR -0.003 0.028 -10000 0 -0.26 3 3
RhoA/GTP 0.013 0.035 -10000 0 -0.26 4 4
AKT2 0.046 0.059 0.17 5 -0.32 3 8
actin cable formation 0.024 0.043 -10000 0 -0.3 2 2
apoptosis -0.039 0.061 0.38 3 -0.19 6 9
CTNNA1 0.027 0.029 -10000 0 -0.45 2 2
mol:GDP 0.002 0.037 0.17 3 -0.33 4 7
PIP5K1A 0.03 0.044 -10000 0 -0.28 4 4
PLCG1 0.006 0.03 -10000 0 -0.24 5 5
Rac1/GTP 0.047 0.052 -10000 0 -0.26 4 4
homophilic cell adhesion 0.002 0.004 -10000 0 -10000 0 0
Aurora A signaling

Figure S126.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S126.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Aurora A/GADD45A 0.045 0.038 -10000 0 -0.26 1 1
BIRC5 0.026 0.006 -10000 0 -10000 0 0
NFKBIA 0.003 0.011 0.24 1 -10000 0 1
CPEB1 -0.009 0.12 -10000 0 -0.44 36 36
AKT1 0.002 0.012 -10000 0 -0.26 1 1
NDEL1 0.022 0.01 -10000 0 -10000 0 0
Aurora A/BRCA1 0.015 0.019 -10000 0 -0.26 1 1
NDEL1/TACC3 0.052 0.035 -10000 0 -10000 0 0
GADD45A 0.024 0.028 -10000 0 -0.44 2 2
GSK3B 0.023 0.025 -10000 0 -0.39 2 2
PAK1/Aurora A 0.047 0.035 -10000 0 -10000 0 0
MDM2 0.025 0.028 -10000 0 -0.44 2 2
JUB 0 0 -10000 0 -10000 0 0
TPX2 -0.008 0.02 -10000 0 -0.32 2 2
TP53 -0.005 0.07 -10000 0 -0.3 27 27
DLG7 0.004 0.005 -10000 0 -10000 0 0
AURKAIP1 0.025 0.021 -10000 0 -0.44 1 1
ARHGEF7 0.02 0.011 -10000 0 -10000 0 0
G2 phase of mitotic cell cycle 0 0 -10000 0 -10000 0 0
Aurora A/NDEL1/TACC3 0.055 0.037 -10000 0 -10000 0 0
G2/M transition of mitotic cell cycle 0.014 0.019 -10000 0 -0.26 1 1
AURKA 0.009 0.009 -10000 0 -10000 0 0
AURKB 0.008 0.01 -10000 0 -0.14 1 1
CDC25B 0.008 0.009 -10000 0 -10000 0 0
G2/M transition checkpoint 0.005 0.007 -10000 0 -10000 0 0
mRNA polyadenylation 0.004 0.056 -10000 0 -0.24 18 18
Aurora A/CPEB 0.004 0.056 -10000 0 -0.24 18 18
Aurora A/TACC1/TRAP/chTOG 0.066 0.048 -10000 0 -0.24 3 3
BRCA1 0.025 0.02 -10000 0 -0.44 1 1
centrosome duplication 0.046 0.035 -10000 0 -10000 0 0
regulation of centrosome cycle 0.05 0.035 -10000 0 -10000 0 0
spindle assembly 0.064 0.047 -10000 0 -0.24 3 3
TDRD7 0.026 0.003 -10000 0 -10000 0 0
Aurora A/RasGAP/Survivin 0.07 0.038 -10000 0 -0.24 1 1
CENPA 0.008 0.028 -10000 0 -0.34 3 3
Aurora A/PP2A 0.046 0.035 -10000 0 -10000 0 0
meiosis 0 0 -10000 0 -10000 0 0
protein catabolic process 0.026 0.046 0.2 2 -10000 0 2
negative regulation of DNA binding -0.014 0.08 -10000 0 -0.29 27 27
prophase 0 0 -10000 0 -10000 0 0
GIT1/beta-PIX 0.029 0.023 -10000 0 -0.32 1 1
RASA1 0.024 0.028 -10000 0 -0.44 2 2
Ajuba/Aurora A 0.005 0.007 -10000 0 -10000 0 0
mitotic prometaphase 0.01 0.028 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.009 0.009 -10000 0 -10000 0 0
TACC1 0.018 0.049 -10000 0 -0.44 6 6
TACC3 0.026 0.006 -10000 0 -10000 0 0
Aurora A/Antizyme1 0.065 0.036 -10000 0 -0.24 1 1
Aurora A/RasGAP 0.045 0.037 -10000 0 -10000 0 0
OAZ1 0.026 0.004 -10000 0 -10000 0 0
RAN 0.026 0.003 -10000 0 -10000 0 0
mitosis 0 0 -10000 0 -10000 0 0
PRKACA 0.025 0.005 -10000 0 -10000 0 0
GIT1 0.025 0.02 -10000 0 -0.44 1 1
GIT1/beta-PIX/PAK1 0.039 0.027 -10000 0 -0.27 1 1
Importin alpha/Importin beta/TPX2 -0.008 0.019 -10000 0 -0.32 2 2
PPP2R5D 0.026 0.004 -10000 0 -10000 0 0
Aurora A/TPX2 0.009 0.016 -10000 0 -0.24 1 1
PAK1 0.026 0.004 -10000 0 -10000 0 0
CKAP5 0.026 0.003 -10000 0 -10000 0 0
TRAIL signaling pathway

Figure S127.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S127.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TNFSF10 0.023 0.04 -9999 0 -0.44 4 4
positive regulation of NF-kappaB transcription factor activity 0.027 0.034 -9999 0 -0.32 4 4
MAP2K4 0.011 0.029 -9999 0 -10000 0 0
IKBKB 0.023 0.009 -9999 0 -10000 0 0
TNFRSF10B 0.02 0.012 -9999 0 -10000 0 0
TNFRSF10A 0.02 0.012 -9999 0 -10000 0 0
SMPD1 0.007 0.023 -9999 0 -0.21 5 5
IKBKG 0.026 0.02 -9999 0 -0.44 1 1
mol:GTP 0 0 -9999 0 -10000 0 0
TNFRSF10D 0.02 0.013 -9999 0 -10000 0 0
TRAIL/TRAILR2 0.027 0.034 -9999 0 -0.32 4 4
TRAIL/TRAILR3 0.028 0.042 -9999 0 -0.32 6 6
TRAIL/TRAILR1 0.027 0.034 -9999 0 -0.32 4 4
TRAIL/TRAILR4 0.027 0.034 -9999 0 -0.32 4 4
TRAIL/TRAILR1/DAP3/GTP 0.035 0.033 -9999 0 -0.25 4 4
IKK complex 0.007 0.06 -9999 0 -0.38 4 4
RIPK1 0.026 0.004 -9999 0 -10000 0 0
response to oxidative stress 0 0 -9999 0 -10000 0 0
DAP3/GTP 0.019 0.003 -9999 0 -10000 0 0
MAPK3 -0.014 0.026 -9999 0 -0.32 4 4
MAP3K1 0.016 0.03 -9999 0 -0.22 5 5
TRAILR4 (trimer) 0.02 0.013 -9999 0 -10000 0 0
TRADD 0.026 0.003 -9999 0 -10000 0 0
TRAILR1 (trimer) 0.02 0.012 -9999 0 -10000 0 0
TRAIL/TRAILR1/FADD/TRADD/RIP/TRAF2 0.016 0.031 -9999 0 -0.22 4 4
CFLAR 0.027 0 -9999 0 -10000 0 0
MAPK1 -0.013 0.026 -9999 0 -0.32 4 4
TRAIL/TRAILR1/FADD/TRADD/RIP 0.056 0.042 -9999 0 -0.24 3 3
mol:ceramide 0.007 0.023 -9999 0 -0.21 5 5
FADD 0.026 0.004 -9999 0 -10000 0 0
MAPK8 -0.001 0.042 -9999 0 -0.3 1 1
TRAF2 0.025 0.02 -9999 0 -0.44 1 1
TRAILR3 (trimer) 0.021 0.034 -9999 0 -0.44 2 2
CHUK 0.023 0.035 -9999 0 -0.44 3 3
TRAIL/TRAILR1/FADD 0.037 0.036 -9999 0 -0.27 4 4
DAP3 0.026 0.004 -9999 0 -10000 0 0
CASP10 -0.007 0.03 -9999 0 -0.29 5 5
JNK cascade 0.027 0.034 -9999 0 -0.32 4 4
TRAIL (trimer) 0.023 0.04 -9999 0 -0.44 4 4
TNFRSF10C 0.021 0.034 -9999 0 -0.44 2 2
TRAIL/TRAILR1/DAP3/GTP/FADD 0.044 0.037 -9999 0 -0.24 4 4
TRAIL/TRAILR2/FADD 0.037 0.036 -9999 0 -0.27 4 4
cell death 0.007 0.023 -9999 0 -0.21 5 5
TRAIL/TRAILR2/FADD/TRADD/RIP/TRAF2 0.016 0.031 -9999 0 -0.22 4 4
TRAILR2 (trimer) 0.02 0.012 -9999 0 -10000 0 0
CASP8 0.014 0.035 -9999 0 -0.76 1 1
negative regulation of caspase activity 0 0 -9999 0 -10000 0 0
TRAIL/TRAILR2/FADD/TRADD/RIP 0.056 0.042 -9999 0 -0.24 3 3
Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Figure S128.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S128.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SMAD4 0.019 0.012 -10000 0 -10000 0 0
SMAD2 0.012 0.037 0.21 1 -0.21 1 2
SMAD3 0.013 0.025 -10000 0 -0.27 1 1
SMAD3/SMAD4 0.018 0.067 -10000 0 -0.45 10 10
SMAD4/Ubc9/PIASy 0.037 0.03 -10000 0 -0.27 1 1
SMAD2/SMAD2/SMAD4 0.035 0.047 -10000 0 -10000 0 0
PPM1A 0.025 0.007 -10000 0 -10000 0 0
CALM1 0.025 0.007 -10000 0 -10000 0 0
SMAD2/SMAD4 0.012 0.031 -10000 0 -0.2 1 1
MAP3K1 0.022 0.044 -10000 0 -0.44 5 5
TRAP-1/SMAD4 0.027 0.027 -10000 0 -0.32 2 2
MAPK3 0.025 0.02 -10000 0 -0.44 1 1
MAPK1 0.025 0.006 -10000 0 -10000 0 0
NUP214 0.026 0.003 -10000 0 -10000 0 0
CTDSP1 0.026 0.02 -10000 0 -0.44 1 1
CTDSP2 0.027 0.002 -10000 0 -10000 0 0
CTDSPL 0.026 0.003 -10000 0 -10000 0 0
KPNB1 0.026 0.004 -10000 0 -10000 0 0
TGFBRAP1 0.025 0.028 -10000 0 -0.44 2 2
UBE2I 0.026 0.004 -10000 0 -10000 0 0
NUP153 0.026 0.004 -10000 0 -10000 0 0
KPNA2 0.026 0.005 -10000 0 -10000 0 0
PIAS4 0.025 0.02 -10000 0 -0.44 1 1
Circadian rhythm pathway

Figure S129.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S129.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
chromatin modification 0.043 0.057 -10000 0 -1.1 1 1
CLOCK 0.027 0.008 -10000 0 -10000 0 0
TIMELESS/CRY2 0.031 0.054 -10000 0 -1.2 1 1
DEC1/BMAL1 0.035 0.019 -10000 0 -0.32 1 1
ATR 0.025 0.028 -10000 0 -0.44 2 2
NR1D1 0.014 0.056 -10000 0 -1.2 1 1
ARNTL 0.026 0.029 -10000 0 -0.44 2 2
TIMELESS 0.015 0.056 -10000 0 -1.2 1 1
NPAS2 0.027 0.021 -10000 0 -0.44 1 1
CRY2 0.026 0.003 -10000 0 -10000 0 0
mol:CO -0.006 0.008 0.14 2 -10000 0 2
CHEK1 0.025 0.02 -10000 0 -0.44 1 1
mol:HEME 0.006 0.008 -10000 0 -0.14 2 2
PER1 0.022 0.024 -10000 0 -0.44 1 1
BMAL/CLOCK/NPAS2 0.058 0.03 -10000 0 -0.27 3 3
BMAL1/CLOCK 0.015 0.071 -10000 0 -0.84 2 2
S phase of mitotic cell cycle 0.043 0.057 -10000 0 -1.1 1 1
TIMELESS/CHEK1/ATR 0.044 0.058 -10000 0 -1.1 1 1
mol:NADPH 0.006 0.008 -10000 0 -0.14 2 2
PER1/TIMELESS 0.026 0.059 -10000 0 -0.86 2 2
PER1-2 / CRY1-2 0 0 -10000 0 -10000 0 0
DEC1 -0.001 0.024 -10000 0 -10000 0 0
E-cadherin signaling events

Figure S130.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S130.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
E-cadherin/beta catenin-gamma catenin 0.051 0.022 -9999 0 -0.27 2 2
E-cadherin/beta catenin 0.038 0.016 -9999 0 -0.32 1 1
CTNNB1 0.026 0.003 -9999 0 -10000 0 0
JUP 0.025 0.02 -9999 0 -0.44 1 1
CDH1 0.026 0.02 -9999 0 -0.44 1 1
Alternative NF-kappaB pathway

Figure S131.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S131.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IKK alpha homodimer 0.035 0.032 -10000 0 -0.32 4 4
FBXW11 0.026 0.004 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0 0 -10000 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.026 0.004 -10000 0 -10000 0 0
CHUK 0.023 0.035 -10000 0 -0.44 3 3
NF kappa B2 p100/RelB 0.07 0.044 -10000 0 -0.34 4 4
NFKB1 0.025 0.02 -10000 0 -0.44 1 1
MAP3K14 0.025 0.02 -10000 0 -0.44 1 1
NF kappa B1 p50/RelB 0.037 0.023 -10000 0 -0.32 2 2
RELB 0.026 0.021 -10000 0 -0.44 1 1
NFKB2 0.025 0.021 -10000 0 -0.44 1 1
NF kappa B2 p52/RelB 0.033 0.025 0.13 1 -0.5 1 2
regulation of B cell activation 0.033 0.024 0.13 1 -0.5 1 2
Inferred Pathway Levels Matrix

Table 3.  Get Full Table First 10 out of 7202 rows and 4 out of 563 columns in the PARADIGM inferred pathway levels matrix.

pid_entity TCGA.QG.A5Z2 TCGA.QG.A5Z1 TCGA.QG.A5YX TCGA.QG.A5YW
109_MAP3K5 0.024 -0.0028 0.031 0.024
47_PPARGC1A 0.027 0.027 0.027 0.027
105_BMP4 0.027 0.027 -0.44 0.027
105_BMP6 0.027 0.027 -0.44 0.027
105_BMP7 0.027 0 0.027 0.027
105_BMP2 0.027 0.027 0.027 0.027
131_RELN/VLDLR 0.069 0.069 -0.25 0.069
30_TGFB1/TGF beta receptor Type II 0.026 0.026 -0.44 0.026
84_STAT5B -0.12 0.071 -0.12 0.04
84_STAT5A -0.12 0.071 -0.12 0.04
Methods & Data
Input

  • Expression Data Normalization = Tumor samples were used to median center the expression data used in this analysis.

  • mRNASeq Expression File Used = /xchip/cga/gdac-prod/tcga-gdac/jobResults/mRNAseq_preprocessor/COADREAD-TP/6044560/COADREAD-TP.uncv2.mRNAseq_RSEM_normalized_log2_PARADIGM.txt

  • Copy Number File Used = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_Gistic2/COADREAD-TP/6154435/Gistic2_Analysis_6154750/all_data_by_genes.txt

Data Sets and Pathway Interactions

Both copy number and expression data are incorporated into PARADIGM's inference. Whenever normal tissue controls are available for analysis in the expression data, each patient's gene-value is normalized by subtracting the gene's median level observed in the normal control. Copy number data is also normalized to reflect the difference in copy number between a gene's levels detected in tumor versus control (e.g. blood normal). The collection of pathways used by PARADIGM includes those from NCI-PID on September 15, 2009 containing 131 pathways, 11,563 interactions, and 7,204 entities. All gene identifiers were translated into HUGO standard identifiers wherever possible. We refer to molecular entities as "concepts," which include gene products such as proteins and miRNAs, small molecules, protein complexes, and abstract concepts. Each concept is represented as "node" in PARADIGM's graphical model. The abstract concepts correspond to general cellular processes (such as "apoptosis" or "DNA damage response") and families of genes that share functional activity such as the RAS family of signal transducers. Various types of concept-concept interactions are included in the pathways including protein-protein interactions, transcriptional regulatory interactions, and protein modifications such as phosphorylation and ubiquitinylation interactions.

Pathway Inference Method

The PARADIGM algorithm (described in PMID: 20529912) assigns an integrated pathway level (IPL) reflecting the activity of a concept determined through a belief propagation strategy. The belief propagation is given the copy number and gene expression measurements of all of the genes and iteratively updates hidden states reflecting the activities of all of the genes in a pathway so as to maximize the likelihood of the observed data given the interactions in the pathway. In the end, the inferred level of a concept reflects both the data observed for the concept and the neighborhood of activity surrounding the concept.

Determining significantly altered levels

The significance of the IPL obtained for each concept in each patient sample is assessed using a permutation analysis. Importantly, the permutation analysis preserves data tuples so as to preserve any implicit correlations between the different data modalities. For example, genes that are deleted have concomitantly lower expression levels. Preserving the copy number and expression pairs therefore retains this data property. The simulation therefore makes "null samples" by permuting data tuples across all of the genes in the genome so that each gene in a null sample is associated with a random tuple of another gene with equal probability. This approach has the added benefit of preserving the pathway structure so that every observed IPL can be compared to a distribution of random IPLs derived from exactly the same interaction context. PARADIGM inferences are then obtained for 1000 "null" patients and serve as a background distribution to contrast the observed IPLs against. Pathway concepts are excluded from further analysis if they did not obtain a minimum IPL of 0.5 in any patient sample both observed or simulated.

An IPL I(i,j) for concept i in sample j, is considered to be deviated if its absolute level is two standard deviations from the average level observed for concept i in the 1000 null samples. The degree to which a concept has significantly altered levels across a patient cohort is summarized in the proportion of deviated samples (PDS) score. For example, a protein with a PDS of 0.10 reflects that the protein's level of activity was inferred to be significantly higher or lower in tumors compared to normal in 10% of the patient samples. An average PDS for a pathway is also reported by computing the mean PDS over all concepts in the pathway.

Download Results

In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.

References
[2] Charles J. Vaske, Stephen C. Benz, J. Zachary Sanborn, Dent Earl, Christopher Szeto, Jingchun Zhu, David Haussler, and Joshua M. Stuart, Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM, Bioinformatics 12(26):237-245 (2010)
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