HotNet pathway analysis of mutation and copy number data
Colon Adenocarcinoma (Primary solid tumor)
23 May 2013  |  analyses__2013_05_23
Maintainer Information
Citation Information
Maintained by Hailei Zhang (Broad Institute)
Cite as Broad Institute TCGA Genome Data Analysis Center (2013): HotNet pathway analysis of mutation and copy number data. Broad Institute of MIT and Harvard. doi:10.7908/C1MK69XM
- Overview
+ Introduction
- Summary

There were 49 significant subnetworks identified in HotNet analysis.

- Results
- Significant subnetworks

HotNet identifies 49 altered subnetworks based on the matched somatic mutation and copy number alterations data. Table 1 showes the top 10 significant subnetworks.

Table 1.  Get Full Table Top 10 out of 49 subnetworks in ranked by p value. The last column of RepeatTimes shows how many times the subnetwork was picked up in differenct delta values.

Network No.ofgenes p-value RepeatTimes
C8A(41),C9(34),C8B(45) 3 0.0000 2
NRAS(52),SHOC2(36),PLCE1(39) 3 0.0000 2
OBSCN(22),ANK1(72),SLC4A3(12) 3 0.0000 2
RHOJ(58),DOCK8(24),DOCK10(16) 3 0.0000 2
TSHR(60),ADRB3(30),CAV3(25),GNAS(112) 4 0.0000 2
PGF(57),GPC1(10),CSDA(17),VEGFA(32),SLIT1(41) 5 0.0045 2
SORBS1(39),FYB(32),SEMA6A(36),EVL(59),DNMBP(38) 5 0.0045 2
SPERT(7),PAK7(73),LZTS2(37),NINL(85),SH3BP5L(14) 5 0.0045 2
ADRB3(30),CAV3(25),GNAS(112) 3 0.0000 1
CHGB(74),YLPM1(62),OGG1(23) 3 0.0000 1
+ Methods & Data