HotNet pathway analysis of mutation and copy number data
Kidney Renal Papillary Cell Carcinoma (Primary solid tumor)
Due to issues with GAF 3.0, we strongly advise caution in the use of these results.
23 September 2013
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analyses__2013_09_23
Maintainer Information
Citation Information
Maintained by Hailei Zhang
(Broad Institute)
Cite as
Broad Institute TCGA Genome Data Analysis Center
(2013):
HotNet pathway analysis of mutation and copy number data.
Broad Institute of MIT and Harvard.
doi:10.7908/C12Z13V5
Overview
Introduction
Summary
There were 28 significant subnetworks identified in HotNet analysis.
Results
Significant subnetworks
HotNet identifies 28 altered subnetworks based on the matched somatic mutation and copy number alterations data. Table 1 showes the top 10 significant subnetworks.
Network | No.ofgenes | p-value | RepeatTimes |
---|---|---|---|
AGTR2(17),PIK3CB(33),ACE(75) | 3 | 0 | 2 |
BAIAP2(75),DIAPH1(1),SHANK1(9) | 3 | 0 | 2 |
DST(13),ITGB4(75),ITGA6(1) | 3 | 0 | 2 |
EIF1AX(17),EIF5B(1),EIF5(26) | 3 | 0 | 2 |
NOL11(75),PMPCB(64),MARK3(25) | 3 | 0 | 2 |
ANKRD23(1),CAPN3(15),TTN(17) | 3 | 0 | 1 |
CEACAM5(9),HNRNPM(8),PTCHD2(24) | 3 | 0 | 1 |
EMD(17),BCLAF1(14),SYNE1(18) | 3 | 0 | 1 |
EPOR(8),SH2B2(65),JAK3(8) | 3 | 0 | 1 |
GAN(1),TBCB(8),UBA1(17) | 3 | 0 | 1 |
Methods & Data
Copyright © 2013
Broad Institute TCGA GDAC as part of the TCGA Research Network.
All rights reserved.