PARADIGM pathway analysis of mRNASeq expression and copy number data
Kidney Renal Papillary Cell Carcinoma (Primary solid tumor)
15 July 2014  |  analyses__2014_07_15
Maintainer Information
Citation Information
doi:10.7908/C19Z93NP
Maintained by Dan DiCara (Broad Institute)
Cite as Broad Institute TCGA Genome Data Analysis Center (2014): PARADIGM pathway analysis of mRNASeq expression and copy number data. Broad Institute of MIT and Harvard. doi:10.7908/C19Z93NP
Overview
Introduction

PAthway Representation and Analysis by Direct Inference on Graphical Models (PARADIGM) predicts the activity of a diverse set of molecular concepts such as genes, complexes, and processes. The predicted activities are called Inferred Pathway Levels (IPLs) and are derived from a probabilistic belief propagation strategy that incorporates multimodal data such as copy number and gene expression estimates with a concept's pathway context.

Summary

There were 25 significant pathways identified in this analysis.

Table 1.  Get Full Table Top 10 out of 131 pathways in order of significance.

Pathway.Name Avg.Num.Perturbations
Nephrin/Neph1 signaling in the kidney podocyte 94
Angiopoietin receptor Tie2-mediated signaling 68
FOXA2 and FOXA3 transcription factor networks 66
EGFR-dependent Endothelin signaling events 62
PDGFR-alpha signaling pathway 41
Thromboxane A2 receptor signaling 35
Glypican 1 network 29
Signaling mediated by p38-alpha and p38-beta 28
BMP receptor signaling 26
Endothelins 22
Results
Summary Table

The following list describes the columns found in Table 2.

  • Pathway.Name = Full pathway name of curated PARADIGM pathway

  • Significance.Ratio = (Ave.Num.Perturbations)/ (Cohort Size) where Cohort Size is 213 . Pathway is significant if Significance.Ratio > 0.05 .

  • Avg.Num.Perturbations = Average number of samples with perturbations across the pathway concepts determined by a background permutation model (>2 standard deviations away from the permuted distribution)

  • Total.Perturbations = Total number of perturbed concepts across all samples (>2 standard deviations away from the permuted distribution)

  • Num.Entities = Number of concepts that belong to the pathway

  • Min.Mean.Truth = Minimum IPL for concepts in the pathway among real samples

  • Max.Mean.Truth = Maximum IPL for concepts in the pathway among real samples

  • Min.Mean.Within = Minimum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Max.Mean.Within = Maximum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Min.Mean.Any = Minimum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes)

  • Max.Mean.Any = Maximum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes).

Table 2.  Get Full Table This summary table provides a report of cancer type specific pathway perturbations. Click on the links in the first column to display more detailed results for each pathway. A pathway is defined as significant (red number in Significance.Ratio column) if the Ave.Num.Perturbationsis > 5% of the cohort size ( 213 ).

Pathway.Name Significance.Ratio Avg.Num.Perturbations Total.Perturbations Num.Entities Min.Mean.Truth Max.Mean.Truth Min.Mean.Within Max.Mean.Within Min.Mean.Any Max.Mean.Within.1
Nephrin/Neph1 signaling in the kidney podocyte 0.4413 94 3222 34 -0.47 0.028 1000 -1000 -0.038 -1000
Angiopoietin receptor Tie2-mediated signaling 0.3192 68 6016 88 -0.86 0.092 1000 -1000 -0.065 -1000
FOXA2 and FOXA3 transcription factor networks 0.3099 66 3077 46 -1.1 0.03 1000 -1000 -0.095 -1000
EGFR-dependent Endothelin signaling events 0.2911 62 1313 21 -0.57 0.038 1000 -1000 -0.05 -1000
PDGFR-alpha signaling pathway 0.1925 41 1847 44 -0.25 0.037 1000 -1000 -0.042 -1000
Thromboxane A2 receptor signaling 0.1643 35 3688 105 -0.57 0.095 1000 -1000 -0.048 -1000
Glypican 1 network 0.1362 29 1411 48 -0.34 0.051 1000 -1000 -0.037 -1000
Signaling mediated by p38-alpha and p38-beta 0.1315 28 1255 44 -0.15 0.027 1000 -1000 -0.033 -1000
BMP receptor signaling 0.1221 26 2145 81 -0.37 0.055 1000 -1000 -0.054 -1000
Endothelins 0.1033 22 2121 96 -0.6 0.039 1000 -1000 -0.056 -1000
Arf6 signaling events 0.0986 21 1343 62 -0.57 0.059 1000 -1000 -0.041 -1000
Signaling events mediated by VEGFR1 and VEGFR2 0.0939 20 2581 125 -0.13 0.061 1000 -1000 -0.058 -1000
Signaling events mediated by Stem cell factor receptor (c-Kit) 0.0939 20 1630 78 -0.25 0.052 1000 -1000 -0.05 -1000
Integrins in angiogenesis 0.0892 19 1608 84 -0.44 0.06 1000 -1000 -0.052 -1000
IL4-mediated signaling events 0.0798 17 1622 91 -0.84 0.44 1000 -1000 -0.1 -1000
Signaling events mediated by PTP1B 0.0751 16 1289 76 -0.57 0.089 1000 -1000 -0.045 -1000
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 0.0751 16 1129 68 -0.47 0.079 1000 -1000 -0.086 -1000
amb2 Integrin signaling 0.0704 15 1286 82 -0.39 0.038 1000 -1000 -0.039 -1000
Neurotrophic factor-mediated Trk receptor signaling 0.0704 15 1865 120 -0.25 0.12 1000 -1000 -0.053 -1000
Ceramide signaling pathway 0.0657 14 1079 76 -0.57 0.2 1000 -1000 -0.035 -1000
S1P1 pathway 0.0657 14 514 36 -0.14 0.027 1000 -1000 -0.044 -1000
Stabilization and expansion of the E-cadherin adherens junction 0.0657 14 1104 74 -0.57 0.064 1000 -1000 -0.07 -1000
FoxO family signaling 0.0610 13 837 64 -0.89 0.063 1000 -1000 -0.058 -1000
Signaling events mediated by the Hedgehog family 0.0516 11 600 52 -0.054 0.04 1000 -1000 -0.041 -1000
Plasma membrane estrogen receptor signaling 0.0516 11 981 86 -0.12 0.048 1000 -1000 -0.061 -1000
LPA4-mediated signaling events 0.0469 10 123 12 -0.15 0.007 1000 -1000 -0.027 -1000
Ephrin A reverse signaling 0.0469 10 75 7 -0.032 0 1000 -1000 -0.017 -1000
Glucocorticoid receptor regulatory network 0.0469 10 1185 114 -0.54 0.13 1000 -1000 -0.049 -1000
TCR signaling in naïve CD8+ T cells 0.0423 9 842 93 -0.22 0.11 1000 -1000 -0.062 -1000
Nongenotropic Androgen signaling 0.0423 9 517 52 -0.12 0.051 1000 -1000 -0.047 -1000
E-cadherin signaling events 0.0423 9 48 5 -0.026 0.027 1000 -1000 -0.003 -1000
Caspase cascade in apoptosis 0.0376 8 632 74 -0.42 0.066 1000 -1000 -0.045 -1000
Noncanonical Wnt signaling pathway 0.0376 8 231 26 -0.17 0.027 1000 -1000 -0.053 -1000
Signaling events regulated by Ret tyrosine kinase 0.0376 8 729 82 -0.067 0.028 1000 -1000 -0.064 -1000
Syndecan-3-mediated signaling events 0.0376 8 293 35 -0.1 0.073 1000 -1000 -0.033 -1000
Coregulation of Androgen receptor activity 0.0329 7 595 76 -0.66 0.05 1000 -1000 -0.022 -1000
ErbB4 signaling events 0.0329 7 533 69 -0.29 0.089 1000 -1000 -0.05 -1000
p75(NTR)-mediated signaling 0.0329 7 955 125 -0.37 0.073 1000 -1000 -0.083 -1000
Calcium signaling in the CD4+ TCR pathway 0.0329 7 226 31 -0.098 0.028 1000 -1000 -0.044 -1000
IL6-mediated signaling events 0.0329 7 573 75 -0.21 0.041 1000 -1000 -0.043 -1000
S1P3 pathway 0.0329 7 334 42 -0.11 0.038 1000 -1000 -0.042 -1000
E-cadherin signaling in keratinocytes 0.0329 7 321 43 -0.21 0.04 1000 -1000 -0.042 -1000
Regulation of nuclear SMAD2/3 signaling 0.0282 6 914 136 -0.47 0.094 1000 -1000 -0.044 -1000
Osteopontin-mediated events 0.0282 6 233 38 -0.071 0.051 1000 -1000 -0.057 -1000
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 0.0282 6 570 85 -0.11 0.11 1000 -1000 -0.051 -1000
Presenilin action in Notch and Wnt signaling 0.0282 6 370 61 -0.15 0.083 1000 -1000 -0.06 -1000
Reelin signaling pathway 0.0282 6 351 56 -0.12 0.07 1000 -1000 -0.049 -1000
RXR and RAR heterodimerization with other nuclear receptor 0.0282 6 335 52 -0.24 0.083 1000 -1000 -0.039 -1000
IL27-mediated signaling events 0.0282 6 318 51 -0.96 0.24 1000 -1000 -0.052 -1000
TCGA08_rtk_signaling 0.0282 6 161 26 -0.2 0.063 1000 -1000 -0.013 -1000
E-cadherin signaling in the nascent adherens junction 0.0282 6 526 76 -0.038 0.048 1000 -1000 -0.062 -1000
Regulation of Telomerase 0.0282 6 645 102 -0.57 0.07 1000 -1000 -0.06 -1000
IL23-mediated signaling events 0.0282 6 394 60 -0.061 0.043 1000 -1000 -0.076 -1000
PDGFR-beta signaling pathway 0.0282 6 611 97 -0.039 0.057 1000 -1000 -0.073 -1000
Visual signal transduction: Rods 0.0282 6 317 52 -0.15 0.052 1000 -1000 -0.039 -1000
Regulation of Androgen receptor activity 0.0282 6 426 70 -0.76 0.043 1000 -1000 -0.053 -1000
Sphingosine 1-phosphate (S1P) pathway 0.0235 5 143 28 -0.11 0.045 1000 -1000 -0.03 -1000
HIF-1-alpha transcription factor network 0.0235 5 421 76 -0.082 0.096 1000 -1000 -0.081 -1000
IFN-gamma pathway 0.0235 5 376 68 -0.31 0.066 1000 -1000 -0.068 -1000
ceramide signaling pathway 0.0235 5 286 49 0 0.041 1000 -1000 -0.038 -1000
TCGA08_p53 0.0235 5 39 7 -0.032 0.029 1000 -1000 -0.009 -1000
EPHB forward signaling 0.0235 5 509 85 -0.12 0.069 1000 -1000 -0.077 -1000
Effects of Botulinum toxin 0.0235 5 150 26 -0.15 0.045 1000 -1000 -0.015 -1000
Syndecan-4-mediated signaling events 0.0235 5 356 67 -0.36 0.1 1000 -1000 -0.051 -1000
Syndecan-1-mediated signaling events 0.0188 4 169 34 -0.035 0.028 1000 -1000 -0.051 -1000
Lissencephaly gene (LIS1) in neuronal migration and development 0.0188 4 232 54 -0.049 0.041 1000 -1000 -0.062 -1000
Cellular roles of Anthrax toxin 0.0188 4 187 39 -0.14 0.036 1000 -1000 -0.027 -1000
Fc-epsilon receptor I signaling in mast cells 0.0188 4 420 97 -0.071 0.05 1000 -1000 -0.068 -1000
Ephrin B reverse signaling 0.0188 4 216 48 -0.024 0.037 1000 -1000 -0.034 -1000
Signaling mediated by p38-gamma and p38-delta 0.0188 4 63 15 -0.01 0.028 1000 -1000 -0.039 -1000
Regulation of p38-alpha and p38-beta 0.0188 4 250 54 -0.13 0.067 1000 -1000 -0.054 -1000
Arf6 trafficking events 0.0188 4 301 71 -0.26 0.046 1000 -1000 -0.034 -1000
BCR signaling pathway 0.0188 4 480 99 -0.051 0.058 1000 -1000 -0.062 -1000
Signaling events mediated by PRL 0.0188 4 137 34 -0.041 0.04 1000 -1000 -0.048 -1000
Class IB PI3K non-lipid kinase events 0.0188 4 12 3 -0.013 0.013 1000 -1000 -0.009 -1000
Ras signaling in the CD4+ TCR pathway 0.0188 4 78 17 -0.011 0.042 1000 -1000 -0.038 -1000
ErbB2/ErbB3 signaling events 0.0141 3 230 65 -0.061 0.048 1000 -1000 -0.055 -1000
Syndecan-2-mediated signaling events 0.0141 3 262 69 -0.39 0.053 1000 -1000 -0.041 -1000
PLK1 signaling events 0.0141 3 329 85 -0.006 0.054 1000 -1000 -0.036 -1000
Class I PI3K signaling events mediated by Akt 0.0141 3 247 68 -0.019 0.055 1000 -1000 -0.039 -1000
IL1-mediated signaling events 0.0141 3 193 62 -0.1 0.072 1000 -1000 -0.057 -1000
S1P5 pathway 0.0141 3 64 17 -0.013 0.027 1000 -1000 -0.019 -1000
Canonical Wnt signaling pathway 0.0141 3 201 51 -0.14 0.074 1000 -1000 -0.055 -1000
Wnt signaling 0.0141 3 25 7 -0.001 0.027 1000 -1000 -0.023 -1000
LPA receptor mediated events 0.0141 3 344 102 -0.08 0.06 1000 -1000 -0.062 -1000
IGF1 pathway 0.0141 3 205 57 -0.018 0.062 1000 -1000 -0.05 -1000
S1P4 pathway 0.0141 3 92 25 -0.011 0.053 1000 -1000 -0.031 -1000
IL12-mediated signaling events 0.0094 2 215 87 -0.18 0.06 1000 -1000 -0.078 -1000
BARD1 signaling events 0.0094 2 141 57 -0.046 0.057 1000 -1000 -0.047 -1000
EPO signaling pathway 0.0094 2 135 55 -0.007 0.074 1000 -1000 -0.05 -1000
mTOR signaling pathway 0.0094 2 140 53 -0.017 0.047 1000 -1000 -0.038 -1000
Nectin adhesion pathway 0.0094 2 179 63 -0.026 0.053 1000 -1000 -0.043 -1000
HIF-2-alpha transcription factor network 0.0094 2 108 43 -0.17 0.094 1000 -1000 -0.05 -1000
Role of Calcineurin-dependent NFAT signaling in lymphocytes 0.0094 2 241 83 -0.24 0.047 1000 -1000 -0.049 -1000
FAS signaling pathway (CD95) 0.0094 2 111 47 -0.11 0.04 1000 -1000 -0.037 -1000
Class I PI3K signaling events 0.0094 2 159 73 -0.02 0.046 1000 -1000 -0.054 -1000
VEGFR1 specific signals 0.0094 2 112 56 -0.015 0.06 1000 -1000 -0.057 -1000
FOXM1 transcription factor network 0.0094 2 102 51 -0.092 0.047 1000 -1000 -0.11 -1000
Aurora B signaling 0.0094 2 198 67 -0.24 0.049 1000 -1000 -0.045 -1000
Signaling events mediated by HDAC Class II 0.0047 1 101 75 -0.083 0.069 1000 -1000 -0.036 -1000
Hedgehog signaling events mediated by Gli proteins 0.0047 1 120 65 -0.011 0.065 1000 -1000 -0.046 -1000
Arf6 downstream pathway 0.0047 1 71 43 -0.042 0.043 1000 -1000 -0.04 -1000
Insulin-mediated glucose transport 0.0047 1 43 32 -0.019 0.048 1000 -1000 -0.037 -1000
Signaling events mediated by HDAC Class I 0.0047 1 107 104 -0.083 0.066 1000 -1000 -0.035 -1000
Retinoic acid receptors-mediated signaling 0.0047 1 85 58 -0.031 0.059 1000 -1000 -0.05 -1000
IL2 signaling events mediated by PI3K 0.0047 1 108 58 -0.016 0.062 1000 -1000 -0.045 -1000
TCGA08_retinoblastoma 0.0047 1 9 8 -0.048 0.031 1000 -1000 -0.007 -1000
Insulin Pathway 0.0047 1 134 74 -0.023 0.07 1000 -1000 -0.054 -1000
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 0.0047 1 54 33 -0.049 0.066 1000 -1000 -0.036 -1000
Regulation of cytoplasmic and nuclear SMAD2/3 signaling 0.0000 0 15 23 -0.013 0.048 1000 -1000 -0.034 -1000
Canonical NF-kappaB pathway 0.0000 0 16 39 0 0.059 1000 -1000 -0.043 -1000
PLK2 and PLK4 events 0.0000 0 0 3 0.009 0.026 1000 -1000 -0.016 -1000
Visual signal transduction: Cones 0.0000 0 24 38 -0.015 0.054 1000 -1000 -0.02 -1000
Circadian rhythm pathway 0.0000 0 5 22 -0.009 0.057 1000 -1000 -0.034 -1000
JNK signaling in the CD4+ TCR pathway 0.0000 0 13 17 0.016 0.045 1000 -1000 -0.041 -1000
a4b1 and a4b7 Integrin signaling 0.0000 0 0 5 0.027 0.04 1000 -1000 0 -1000
Aurora A signaling 0.0000 0 19 60 -0.012 0.061 1000 -1000 -0.03 -1000
Aurora C signaling 0.0000 0 0 7 -0.016 0.028 1000 -1000 -0.015 -1000
Paxillin-independent events mediated by a4b1 and a4b7 0.0000 0 4 37 -0.009 0.063 1000 -1000 -0.037 -1000
Signaling events mediated by HDAC Class III 0.0000 0 17 40 -0.048 0.05 1000 -1000 -0.021 -1000
TRAIL signaling pathway 0.0000 0 7 48 0 0.071 1000 -1000 -0.041 -1000
Paxillin-dependent events mediated by a4b1 0.0000 0 0 36 -0.053 0.056 1000 -1000 -0.043 -1000
Atypical NF-kappaB pathway 0.0000 0 9 31 0 0.04 1000 -1000 -0.03 -1000
HIV-1 Nef: Negative effector of Fas and TNF-alpha 0.0000 0 43 45 0 0.077 1000 -1000 -0.06 -1000
Glypican 2 network 0.0000 0 0 4 -0.003 0.001 1000 -1000 0.003 -1000
Sumoylation by RanBP2 regulates transcriptional repression 0.0000 0 1 27 0 0.062 1000 -1000 -0.037 -1000
IL2 signaling events mediated by STAT5 0.0000 0 11 22 0 0.04 1000 -1000 -0.048 -1000
Rapid glucocorticoid signaling 0.0000 0 8 20 -0.003 0.034 1000 -1000 -0.005 -1000
p38 MAPK signaling pathway 0.0000 0 31 44 0 0.053 1000 -1000 -0.041 -1000
Arf1 pathway 0.0000 0 20 54 -0.001 0.048 1000 -1000 -0.019 -1000
Alternative NF-kappaB pathway 0.0000 0 0 13 0 0.074 1000 -1000 -0.002 -1000
Total NA 1084 69879 7203 -24 7.8 131000 -131000 -5.8 -131000
Nephrin/Neph1 signaling in the kidney podocyte

Figure S1.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S1.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
positive regulation of NF-kappaB transcription factor activity 0.38 0.29 0.57 141 -10000 0 141
KIRREL -0.11 0.2 -10000 0 -0.7 20 20
Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.38 0.29 -10000 0 -0.57 141 141
PLCG1 0.027 0.006 -10000 0 -10000 0 0
ARRB2 0.025 0.01 -10000 0 -10000 0 0
WASL 0.022 0.011 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/CD2AP -0.4 0.32 -10000 0 -0.56 155 155
ChemicalAbstracts:57-88-5 0 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.34 0.26 -10000 0 -0.49 140 140
FYN -0.4 0.28 0.27 1 -0.53 155 156
mol:Ca2+ -0.4 0.31 -10000 0 -0.56 151 151
mol:DAG -0.4 0.31 -10000 0 -0.56 151 151
NPHS2 -0.31 0.32 -10000 0 -0.71 84 84
mol:IP3 -0.4 0.31 -10000 0 -0.56 151 151
regulation of endocytosis -0.36 0.28 -10000 0 -0.51 152 152
Nephrin/NEPH1/podocin/Cholesterol -0.41 0.31 -10000 0 -0.56 155 155
establishment of cell polarity -0.38 0.29 -10000 0 -0.57 141 141
Nephrin/NEPH1/podocin/NCK1-2 -0.38 0.3 -10000 0 -0.53 154 154
Nephrin/NEPH1/beta Arrestin2 -0.36 0.29 -10000 0 -0.52 152 152
NPHS1 -0.45 0.32 -10000 0 -0.69 135 135
Nephrin/NEPH1/podocin -0.39 0.3 -10000 0 -0.54 155 155
TJP1 0.027 0.005 -10000 0 -10000 0 0
NCK1 0.027 0.006 -10000 0 -10000 0 0
NCK2 0.028 0.003 -10000 0 -10000 0 0
heterophilic cell adhesion 0 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/PLCgamma1 -0.4 0.32 -10000 0 -0.57 151 151
CD2AP 0.026 0.007 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/GRB2 -0.4 0.31 -10000 0 -0.57 150 150
GRB2 0.026 0.008 -10000 0 -10000 0 0
homophilic cell adhesion 0 0 -10000 0 -10000 0 0
TRPC6 -0.47 0.31 0.28 1 -0.59 166 167
cytoskeleton organization -0.41 0.32 -10000 0 -0.6 142 142
Nephrin/NEPH1 -0.28 0.22 -10000 0 -0.42 141 141
Nephrin/NEPH1/ZO-1 -0.31 0.25 -10000 0 -0.48 137 137
Angiopoietin receptor Tie2-mediated signaling

Figure S2.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S2.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
AKT1 -0.52 0.53 -10000 0 -1 113 113
NCK1/PAK1/Dok-R -0.24 0.22 -10000 0 -0.44 112 112
NCK1/Dok-R -0.65 0.69 -10000 0 -1.3 112 112
PIK3CA 0.028 0.005 -10000 0 -10000 0 0
mol:beta2-estradiol 0.078 0.11 0.24 67 -10000 0 67
RELA 0.028 0.002 -10000 0 -10000 0 0
SHC1 0.026 0.005 -10000 0 -10000 0 0
Rac/GDP 0.017 0.008 -10000 0 -10000 0 0
F2 0.092 0.12 0.26 67 -10000 0 67
TNIP2 0.027 0.005 -10000 0 -10000 0 0
NF kappa B/RelA -0.58 0.64 -10000 0 -1.2 111 111
FN1 0.021 0.025 -10000 0 -10000 0 0
PLD2 -0.7 0.72 -10000 0 -1.3 113 113
PTPN11 0.027 0.006 -10000 0 -10000 0 0
GRB14 -0.011 0.16 -10000 0 -0.61 13 13
ELK1 -0.59 0.6 -10000 0 -1.1 113 113
GRB7 0.026 0.008 -10000 0 -10000 0 0
PAK1 0.028 0.003 -10000 0 -10000 0 0
Tie2/Ang1/alpha5/beta1 Integrin -0.62 0.68 -10000 0 -1.2 113 113
CDKN1A -0.35 0.35 -10000 0 -0.67 111 111
ITGA5 0.027 0.005 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
RasGAP/Dok-R -0.65 0.7 -10000 0 -1.3 112 112
CRK 0.026 0.008 -10000 0 -10000 0 0
mol:NO -0.35 0.38 -10000 0 -0.69 113 113
PLG -0.86 0.69 -10000 0 -1.4 113 113
mol:GDP 0 0 -10000 0 -10000 0 0
chemokinesis -0.48 0.49 -10000 0 -0.93 113 113
GRB2 0.026 0.008 -10000 0 -10000 0 0
PIK3R1 0.026 0.004 -10000 0 -10000 0 0
ANGPT2 -0.26 0.3 -10000 0 -0.73 49 49
BMX -0.7 0.72 -10000 0 -1.3 113 113
ANGPT1 -0.45 0.63 -10000 0 -1.4 67 67
tube development -0.4 0.4 -10000 0 -0.76 113 113
ANGPT4 0.012 0.024 -10000 0 -10000 0 0
response to hypoxia -0.036 0.034 -10000 0 -10000 0 0
Tie2/Ang1/GRB14 -0.74 0.76 -10000 0 -1.4 113 113
alpha5/beta1 Integrin 0.039 0.01 -10000 0 -10000 0 0
FGF2 0.027 0.007 -10000 0 -10000 0 0
STAT5A (dimer) -0.46 0.47 -10000 0 -0.88 112 112
mol:L-citrulline -0.35 0.38 -10000 0 -0.69 113 113
AGTR1 -0.19 0.32 -10000 0 -0.65 67 67
MAPK14 -0.7 0.71 -10000 0 -1.3 113 113
Tie2/SHP2 -0.57 0.62 -10000 0 -1.2 98 98
TEK -0.63 0.7 -10000 0 -1.4 98 98
RPS6KB1 -0.49 0.5 -10000 0 -0.94 113 113
Angiotensin II/AT1 -0.14 0.24 -10000 0 -0.49 67 67
Tie2/Ang1/GRB2 -0.72 0.76 -10000 0 -1.4 113 113
MAPK3 -0.6 0.62 -10000 0 -1.2 112 112
MAPK1 -0.62 0.62 -10000 0 -1.2 113 113
Tie2/Ang1/GRB7 -0.72 0.76 -10000 0 -1.4 113 113
NFKB1 0.027 0.006 -10000 0 -10000 0 0
MAPK8 -0.7 0.73 -10000 0 -1.3 113 113
PI3K -0.62 0.64 -10000 0 -1.2 113 113
FES -0.7 0.71 -10000 0 -1.3 113 113
Crk/Dok-R -0.65 0.69 -10000 0 -1.3 111 111
Tie2/Ang1/ABIN2 -0.72 0.77 -10000 0 -1.4 113 113
blood circulation 0 0 -10000 0 -10000 0 0
negative regulation of caspase activity -0.45 0.46 -10000 0 -0.88 113 113
STAT5A 0.026 0.008 -10000 0 -10000 0 0
mol:ROS 0 0 -10000 0 -10000 0 0
PTK2 -0.5 0.5 -10000 0 -0.96 113 113
Tie2/Ang2 -0.59 0.6 -10000 0 -1.1 113 113
Tie2/Ang1 -0.79 0.84 -10000 0 -1.5 113 113
FOXO1 -0.46 0.47 -10000 0 -0.89 113 113
ELF1 -0.038 0.073 -10000 0 -10000 0 0
ELF2 -0.7 0.73 -10000 0 -1.4 112 112
mol:Choline -0.64 0.66 -10000 0 -1.2 113 113
cell migration -0.13 0.12 -10000 0 -0.24 112 112
FYN -0.47 0.47 -10000 0 -0.9 113 113
DOK2 0.018 0.052 -10000 0 -0.66 1 1
negative regulation of cell cycle -0.31 0.32 -10000 0 -0.6 113 113
ETS1 -0.066 0.12 -10000 0 -0.25 62 62
PXN -0.39 0.4 -10000 0 -0.76 112 112
ITGB1 0.027 0.005 -10000 0 -10000 0 0
NOS3 -0.41 0.44 -10000 0 -0.8 113 113
RAC1 0.022 0.011 -10000 0 -10000 0 0
TNF -0.076 0.14 -10000 0 -0.27 64 64
MAPKKK cascade -0.64 0.66 -10000 0 -1.2 113 113
RASA1 0.027 0.005 -10000 0 -10000 0 0
Tie2/Ang1/Shc -0.72 0.77 -10000 0 -1.4 113 113
NCK1 0.027 0.006 -10000 0 -10000 0 0
vasculogenesis -0.31 0.34 -10000 0 -0.61 113 113
mol:Phosphatidic acid -0.64 0.66 -10000 0 -1.2 113 113
mol:Angiotensin II 0 0.001 -10000 0 -10000 0 0
mol:NADP -0.35 0.38 -10000 0 -0.69 113 113
Rac1/GTP -0.44 0.45 -10000 0 -0.86 113 113
MMP2 -0.69 0.72 -10000 0 -1.3 112 112
FOXA2 and FOXA3 transcription factor networks

Figure S3.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S3.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ACADVL -0.52 0.38 -9999 0 -0.92 83 83
PCK1 -1.1 0.65 -9999 0 -1.5 152 152
HNF4A -0.6 0.51 -9999 0 -1.2 67 67
KCNJ11 -0.55 0.38 -9999 0 -0.97 81 81
AKT1 -0.28 0.16 -9999 0 -0.47 49 49
response to starvation -0.003 0.013 -9999 0 -10000 0 0
DLK1 -0.56 0.4 -9999 0 -1 82 82
NKX2-1 -0.15 0.15 -9999 0 -0.56 4 4
ACADM -0.52 0.38 -9999 0 -0.92 85 85
TAT -0.46 0.23 -9999 0 -0.72 63 63
CEBPB -0.043 0.048 -9999 0 -10000 0 0
CEBPA -0.05 0.065 -9999 0 -0.45 2 2
TTR -0.78 0.42 -9999 0 -1.1 112 112
PKLR -0.66 0.55 -9999 0 -1.2 87 87
APOA1 -0.67 0.55 -9999 0 -1.3 77 77
CPT1C -0.53 0.38 -9999 0 -0.94 84 84
ALAS1 -0.23 0.15 -9999 0 -0.64 3 3
TFRC -0.61 0.29 -9999 0 -0.83 109 109
FOXF1 0.019 0.067 -9999 0 -0.66 2 2
NF1 0.03 0.008 -9999 0 -10000 0 0
HNF1A (dimer) -0.065 0.11 -9999 0 -0.7 4 4
CPT1A -0.52 0.37 -9999 0 -0.94 80 80
HMGCS1 -0.52 0.38 -9999 0 -0.92 83 83
NR3C1 0.016 0.052 -9999 0 -10000 0 0
CPT1B -0.52 0.38 -9999 0 -0.92 85 85
chromatin remodeling 0 0 -9999 0 -10000 0 0
SP1 0.027 0.009 -9999 0 -10000 0 0
GCK -0.49 0.39 -9999 0 -0.94 75 75
CREB1 -0.1 0.076 -9999 0 -0.23 12 12
IGFBP1 -0.29 0.37 -9999 0 -1.3 21 21
PDX1 -0.28 0.2 -9999 0 -0.66 22 22
UCP2 -0.53 0.38 -9999 0 -0.92 88 88
ALDOB -1.1 0.36 -9999 0 -1.2 202 202
AFP -0.45 0.31 -9999 0 -0.56 132 132
BDH1 -0.52 0.38 -9999 0 -0.92 85 85
HADH -0.55 0.39 -9999 0 -0.97 80 80
F2 -0.62 0.47 -9999 0 -1.2 69 69
HNF1A -0.065 0.11 -9999 0 -0.7 4 4
G6PC -1.1 0.58 -9999 0 -1.4 148 148
SLC2A2 -0.51 0.58 -9999 0 -1.6 42 42
INS -0.008 0.054 -9999 0 -10000 0 0
FOXA1 -0.21 0.11 -9999 0 -0.26 152 152
FOXA3 -0.45 0.22 -9999 0 -0.48 196 196
FOXA2 -0.63 0.43 -9999 0 -1.1 85 85
ABCC8 -0.55 0.38 -9999 0 -0.98 80 80
ALB -1 0.36 -9999 0 -1.1 190 190
EGFR-dependent Endothelin signaling events

Figure S4.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S4.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HRAS 0.028 0.003 -9999 0 -10000 0 0
EGFR 0.022 0.011 -9999 0 -10000 0 0
EGF/EGFR -0.29 0.15 -9999 0 -0.38 140 140
EGF/EGFR dimer/SHC/GRB2/SOS1 -0.27 0.15 -9999 0 -0.38 129 129
mol:GTP 0 0 -9999 0 -10000 0 0
EDNRA 0.001 0.13 -9999 0 -0.66 8 8
response to oxidative stress 0 0 -9999 0 -10000 0 0
EGF -0.57 0.22 -9999 0 -0.64 188 188
EGF/EGFR dimer/SHC -0.33 0.16 -9999 0 -0.43 137 137
mol:GDP -0.27 0.15 -9999 0 -0.37 129 129
mol:Ca2+ 0 0 -9999 0 -10000 0 0
EDN1 0.026 0.009 -9999 0 -10000 0 0
GRB2/SOS1 0.038 0.013 -9999 0 -10000 0 0
HRAS/GTP -0.25 0.14 -9999 0 -0.35 129 129
SHC1 0.027 0.005 -9999 0 -10000 0 0
HRAS/GDP -0.26 0.14 -9999 0 -0.36 129 129
FRAP1 -0.27 0.13 -9999 0 -0.36 129 129
EGF/EGFR dimer -0.38 0.18 -9999 0 -0.44 187 187
SOS1 0.027 0.004 -9999 0 -10000 0 0
GRB2 0.026 0.008 -9999 0 -10000 0 0
ETA receptor/Endothelin-1 0.017 0.1 -9999 0 -0.5 8 8
PDGFR-alpha signaling pathway

Figure S5.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S5.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRA -0.21 0.32 -10000 0 -0.66 71 71
PDGF/PDGFRA/CRKL -0.14 0.25 -10000 0 -0.48 71 71
positive regulation of JUN kinase activity -0.075 0.2 -10000 0 -0.39 58 58
CRKL 0.026 0.008 -10000 0 -10000 0 0
PDGF/PDGFRA/Caveolin-3 -0.14 0.24 -10000 0 -0.48 71 71
AP1 -0.25 0.4 -10000 0 -1.1 33 33
mol:IP3 -0.16 0.24 -10000 0 -0.48 71 71
PLCG1 -0.16 0.24 -10000 0 -0.48 71 71
PDGF/PDGFRA/alphaV Integrin -0.14 0.25 -10000 0 -0.48 71 71
RAPGEF1 0.026 0.007 -10000 0 -10000 0 0
CRK 0.026 0.008 -10000 0 -10000 0 0
mol:Ca2+ -0.16 0.24 -10000 0 -0.48 71 71
CAV3 -0.009 0.019 -10000 0 -10000 0 0
CAV1 0.022 0.013 -10000 0 -10000 0 0
SHC/Grb2/SOS1 -0.074 0.2 -10000 0 -0.39 58 58
PDGF/PDGFRA/Shf -0.14 0.25 -10000 0 -0.49 70 70
FOS -0.25 0.4 0.32 1 -1.1 33 34
JUN -0.032 0.026 -10000 0 -10000 0 0
oligodendrocyte development -0.14 0.24 -10000 0 -0.48 71 71
GRB2 0.026 0.008 -10000 0 -10000 0 0
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
mol:DAG -0.16 0.24 -10000 0 -0.48 71 71
PDGF/PDGFRA -0.21 0.32 -10000 0 -0.66 71 71
actin cytoskeleton reorganization -0.14 0.25 -10000 0 -0.49 70 70
SRF 0.017 0.01 -10000 0 -10000 0 0
SHC1 0.027 0.005 -10000 0 -10000 0 0
PI3K -0.1 0.22 -10000 0 -0.41 68 68
PDGF/PDGFRA/Crk/C3G -0.1 0.21 -10000 0 -0.4 68 68
JAK1 -0.15 0.24 -10000 0 -0.49 69 69
ELK1/SRF -0.13 0.18 -10000 0 -0.4 59 59
SHB 0.027 0.006 -10000 0 -10000 0 0
SHF 0.027 0.005 -10000 0 -10000 0 0
CSNK2A1 0.037 0.02 -10000 0 -10000 0 0
GO:0007205 -0.17 0.24 -10000 0 -0.5 71 71
SOS1 0.027 0.004 -10000 0 -10000 0 0
Ras protein signal transduction -0.075 0.2 -10000 0 -0.39 58 58
PDGF/PDGFRA/SHB -0.14 0.25 -10000 0 -0.49 70 70
PDGF/PDGFRA/Caveolin-1 -0.12 0.23 -10000 0 -0.43 71 71
ITGAV 0.028 0.003 -10000 0 -10000 0 0
ELK1 -0.16 0.22 0.26 1 -0.46 69 70
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
PDGF/PDGFRA/Crk -0.13 0.24 -10000 0 -0.46 71 71
JAK-STAT cascade -0.15 0.24 -10000 0 -0.49 69 69
cell proliferation -0.14 0.25 -10000 0 -0.49 70 70
Thromboxane A2 receptor signaling

Figure S6.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S6.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGM2 0.018 0.025 -10000 0 -10000 0 0
GNB1/GNG2 -0.092 0.09 -10000 0 -0.18 99 99
AKT1 -0.088 0.14 0.22 3 -0.32 17 20
EGF -0.57 0.22 -10000 0 -0.64 188 188
mol:TXA2 -0.001 0.001 -10000 0 -10000 0 0
FGR -0.018 0.082 -10000 0 -0.34 7 7
mol:Ca2+ -0.13 0.17 0.22 1 -0.3 90 91
LYN -0.019 0.073 -10000 0 -0.31 7 7
RhoA/GTP -0.053 0.068 -10000 0 -0.14 11 11
mol:PGI2 0 0 -10000 0 -10000 0 0
SYK -0.15 0.19 -10000 0 -0.34 101 101
GNG2 0.026 0.007 -10000 0 -10000 0 0
ARRB2 0.025 0.01 -10000 0 -10000 0 0
TP alpha/Gq family/GDP/G beta5/gamma2 -0.049 0.13 -10000 0 -0.51 9 9
G beta5/gamma2 -0.12 0.12 -10000 0 -0.24 98 98
PRKCH -0.16 0.2 -10000 0 -0.35 101 101
DNM1 -0.002 0.045 -10000 0 -10000 0 0
TXA2/TP beta/beta Arrestin3 0.008 0.021 -10000 0 -10000 0 0
mol:GTP -0.001 0.001 -10000 0 -10000 0 0
PTGDR 0.026 0.008 -10000 0 -10000 0 0
G12 family/GTP -0.13 0.15 -10000 0 -0.31 71 71
ADRBK1 0.028 0.002 -10000 0 -10000 0 0
ADRBK2 0.025 0.008 -10000 0 -10000 0 0
RhoA/GTP/ROCK1 0.033 0.012 -10000 0 -10000 0 0
mol:GDP 0.095 0.15 0.44 20 -10000 0 20
mol:NADP 0.006 0.1 -10000 0 -0.66 5 5
RAB11A 0.028 0.004 -10000 0 -10000 0 0
PRKG1 -0.13 0.28 -10000 0 -0.65 48 48
mol:IP3 -0.16 0.21 -10000 0 -0.38 90 90
cell morphogenesis 0.033 0.012 -10000 0 -10000 0 0
PLCB2 -0.23 0.28 -10000 0 -0.51 98 98
mol:cGMP -0.001 0.001 -10000 0 -10000 0 0
BLK -0.02 0.071 -10000 0 -0.31 6 6
mol:PDG2 0 0 -10000 0 -10000 0 0
HCK -0.024 0.074 -10000 0 -0.35 6 6
RHOA 0.027 0.006 -10000 0 -10000 0 0
PTGIR 0.021 0.066 -10000 0 -0.66 2 2
PRKCB1 -0.17 0.21 -10000 0 -0.37 101 101
GNAQ 0.026 0.007 -10000 0 -10000 0 0
mol:L-citrulline 0.006 0.1 -10000 0 -0.66 5 5
TXA2/TXA2-R family -0.23 0.28 -10000 0 -0.52 101 101
LCK -0.018 0.074 -10000 0 -0.31 7 7
TXA2/TP beta/beta Arrestin3/RAB11/GDP 0.005 0.097 -10000 0 -0.34 14 14
TXA2-R family/G12 family/GDP/G beta/gamma -0.018 0.13 -10000 0 -0.43 19 19
TXA2/TP beta/beta Arrestin2/RAB11/GDP 0.009 0.094 -10000 0 -0.34 12 12
MAPK14 -0.099 0.13 0.19 1 -0.23 74 75
TGM2/GTP -0.18 0.23 -10000 0 -0.42 81 81
MAPK11 -0.099 0.13 0.19 1 -0.23 74 75
ARHGEF1 -0.076 0.091 -10000 0 -0.18 69 69
GNAI2 0.027 0.007 -10000 0 -10000 0 0
JNK cascade -0.17 0.21 -10000 0 -0.38 101 101
RAB11/GDP 0.028 0.004 -10000 0 -10000 0 0
ICAM1 -0.12 0.16 0.21 1 -0.28 101 102
cAMP biosynthetic process -0.15 0.19 -10000 0 -0.35 84 84
Gq family/GTP/EBP50 -0.043 0.1 -10000 0 -0.32 8 8
actin cytoskeleton reorganization 0.033 0.012 -10000 0 -10000 0 0
SRC -0.019 0.066 -10000 0 -0.31 6 6
GNB5 0.027 0.005 -10000 0 -10000 0 0
GNB1 0.025 0.008 -10000 0 -10000 0 0
EGF/EGFR -0.12 0.084 0.25 1 -0.31 16 17
VCAM1 -0.12 0.16 0.21 1 -0.29 101 102
TP beta/Gq family/GDP/G beta5/gamma2 -0.049 0.13 -10000 0 -0.51 9 9
platelet activation -0.13 0.17 0.26 1 -0.3 95 96
PGI2/IP 0.015 0.05 -10000 0 -0.49 2 2
PRKACA 0.014 0.033 -10000 0 -0.32 2 2
Gq family/GDP/G beta5/gamma2 -0.043 0.12 -10000 0 -0.44 10 10
TXA2/TP beta/beta Arrestin2 0.005 0.045 -10000 0 -0.34 2 2
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
TBXA2R -0.016 0.099 -10000 0 -0.38 14 14
mol:DAG -0.19 0.23 -10000 0 -0.42 101 101
EGFR 0.022 0.011 -10000 0 -10000 0 0
TXA2/TP alpha -0.21 0.26 -10000 0 -0.48 84 84
Gq family/GTP -0.052 0.12 -10000 0 -0.26 49 49
YES1 -0.017 0.074 -10000 0 -0.46 1 1
GNAI2/GTP -0.004 0.085 -10000 0 -0.33 11 11
PGD2/DP 0.019 0.006 -10000 0 -10000 0 0
SLC9A3R1 0.026 0.008 -10000 0 -10000 0 0
FYN -0.018 0.074 -10000 0 -0.31 7 7
mol:NO 0.006 0.1 -10000 0 -0.66 5 5
GNA15 0.022 0.023 -10000 0 -10000 0 0
PGK/cGMP -0.072 0.19 -10000 0 -0.38 52 52
RhoA/GDP 0.028 0.007 -10000 0 -10000 0 0
TP alpha/TGM2/GDP/G beta/gamma 0.022 0.096 -10000 0 -0.36 10 10
NOS3 0.006 0.1 -10000 0 -0.66 5 5
RAC1 0.022 0.011 -10000 0 -10000 0 0
PRKCA -0.15 0.19 0.28 2 -0.35 93 95
PRKCB -0.15 0.2 0.29 2 -0.36 90 92
PRKCE -0.16 0.2 0.27 1 -0.36 101 102
PRKCD -0.17 0.21 -10000 0 -0.38 99 99
PRKCG -0.17 0.21 -10000 0 -0.39 101 101
muscle contraction -0.21 0.26 -10000 0 -0.48 101 101
PRKCZ -0.15 0.19 0.23 1 -0.34 101 102
ARR3 -0.01 0.018 -10000 0 -10000 0 0
TXA2/TP beta 0.003 0.099 -10000 0 -0.35 14 14
PRKCQ -0.16 0.2 -10000 0 -0.36 102 102
MAPKKK cascade -0.2 0.24 -10000 0 -0.44 100 100
SELE -0.18 0.22 0.21 1 -0.41 101 102
TP beta/GNAI2/GDP/G beta/gamma 0.025 0.098 -10000 0 -0.35 11 11
ROCK1 0.026 0.007 -10000 0 -10000 0 0
GNA14 -0.11 0.27 -10000 0 -0.64 44 44
chemotaxis -0.27 0.32 -10000 0 -0.6 101 101
GNA12 0.023 0.011 -10000 0 -10000 0 0
GNA13 0.026 0.008 -10000 0 -10000 0 0
GNA11 0.012 0.1 -10000 0 -0.66 5 5
Rac1/GTP 0.016 0.008 -10000 0 -10000 0 0
Glypican 1 network

Figure S7.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S7.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GPC1/FGF2 dimer/FGFR1 dimer 0.051 0.019 -10000 0 -10000 0 0
fibroblast growth factor receptor signaling pathway 0.05 0.019 -10000 0 -10000 0 0
LAMA1 0.003 0.11 -10000 0 -0.66 5 5
PRNP 0.027 0.006 -10000 0 -10000 0 0
GPC1/SLIT2 -0.068 0.21 -10000 0 -0.47 44 44
SMAD2 0.016 0.024 -10000 0 -10000 0 0
GPC1/PrPc/Cu2+ 0.035 0.012 -10000 0 -10000 0 0
GPC1/Laminin alpha1 0.019 0.084 -10000 0 -0.5 5 5
TDGF1 -0.34 0.33 -10000 0 -0.65 111 111
CRIPTO/GPC1 -0.24 0.26 -10000 0 -0.49 111 111
APP/GPC1 0.037 0.015 -10000 0 -10000 0 0
mol:NO 0 0 -10000 0 -10000 0 0
YES1 -0.22 0.21 -10000 0 -0.43 105 105
FLT1 0.02 0.067 -10000 0 -0.66 2 2
GPC1/TGFB/TGFBR1/TGFBR2 0.051 0.018 -10000 0 -10000 0 0
SERPINC1 -0.16 0.3 -10000 0 -0.65 57 57
FYN -0.22 0.21 -10000 0 -0.43 108 108
FGR -0.22 0.22 -10000 0 -0.43 108 108
positive regulation of MAPKKK cascade -0.23 0.24 0.5 2 -0.45 109 111
SLIT2 -0.11 0.27 -10000 0 -0.63 44 44
GPC1/NRG 0.028 0.074 -10000 0 -0.5 4 4
NRG1 0.013 0.094 -10000 0 -0.66 4 4
GPC1/VEGF165 homodimer/VEGFR1 homodimer 0.046 0.051 -10000 0 -0.43 2 2
LYN -0.22 0.21 -10000 0 -0.43 107 107
mol:Spermine 0.007 0.004 -10000 0 -10000 0 0
cell growth 0.05 0.019 -10000 0 -10000 0 0
BMP signaling pathway -0.027 0.009 -10000 0 -10000 0 0
SRC -0.22 0.21 -10000 0 -0.43 103 103
TGFBR1 0.027 0.007 -10000 0 -10000 0 0
mol:Cu2+ 0 0 -10000 0 -10000 0 0
PLA2G2A -0.004 0.029 -10000 0 -10000 0 0
GPC1 0.027 0.009 -10000 0 -10000 0 0
TGFBR1 (dimer) 0.027 0.007 -10000 0 -10000 0 0
VEGFA 0.026 0.009 -10000 0 -10000 0 0
BLK -0.22 0.21 -10000 0 -0.43 106 106
HCK -0.22 0.21 -10000 0 -0.44 103 103
FGF2 0.027 0.007 -10000 0 -10000 0 0
FGFR1 0.027 0.006 -10000 0 -10000 0 0
VEGFR1 homodimer 0.02 0.066 -10000 0 -0.66 2 2
TGFBR2 0.027 0.006 -10000 0 -10000 0 0
cell death 0.037 0.014 -10000 0 -10000 0 0
ATIII/GPC1 -0.1 0.23 -10000 0 -0.49 57 57
PLA2G2A/GPC1 0.026 0.026 -10000 0 -10000 0 0
LCK -0.22 0.21 -10000 0 -0.43 108 108
neuron differentiation 0.027 0.074 -10000 0 -0.5 4 4
PrPc/Cu2+ 0.02 0.005 -10000 0 -10000 0 0
APP 0.026 0.008 -10000 0 -10000 0 0
TGFBR2 (dimer) 0.027 0.006 -10000 0 -10000 0 0
Signaling mediated by p38-alpha and p38-beta

Figure S8.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S8.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTGS2 -0.15 0.42 -10000 0 -1.1 32 32
MKNK1 0.026 0.007 -10000 0 -10000 0 0
MAPK14 -0.025 0.14 -10000 0 -0.35 31 31
ATF2/c-Jun -0.031 0.12 -10000 0 -0.44 6 6
MAPK11 -0.024 0.14 -10000 0 -0.34 34 34
MITF -0.039 0.16 -10000 0 -0.39 35 35
MAPKAPK5 -0.041 0.16 -10000 0 -0.39 36 36
KRT8 -0.042 0.16 -10000 0 -0.39 36 36
MAPKAPK3 0.027 0.007 -10000 0 -10000 0 0
MAPKAPK2 0.027 0.006 -10000 0 -10000 0 0
p38alpha-beta/CK2 -0.048 0.23 -10000 0 -0.5 37 37
CEBPB -0.042 0.17 -10000 0 -0.4 36 36
SLC9A1 -0.048 0.18 -10000 0 -0.41 38 38
mol:GDP 0 0 -10000 0 -10000 0 0
ATF2 -0.039 0.16 -10000 0 -0.39 34 34
p38alpha-beta/MNK1 -0.025 0.2 -10000 0 -0.45 31 31
JUN -0.033 0.12 -10000 0 -0.43 6 6
PPARGC1A -0.055 0.19 -10000 0 -0.42 40 40
USF1 -0.05 0.18 -10000 0 -0.41 39 39
RAB5/GDP/GDI1 -0.03 0.13 -10000 0 -0.3 33 33
NOS2 -0.094 0.33 -10000 0 -1.2 16 16
DDIT3 -0.041 0.16 -10000 0 -0.39 36 36
RAB5A 0.027 0.006 -10000 0 -10000 0 0
HSPB1 0.004 0.16 0.28 29 -0.38 12 41
p38alpha-beta/HBP1 -0.026 0.18 -10000 0 -0.45 25 25
CREB1 -0.054 0.19 -10000 0 -0.43 39 39
RAB5/GDP 0.02 0.004 -10000 0 -10000 0 0
EIF4E -0.045 0.16 -10000 0 -0.41 28 28
RPS6KA4 -0.046 0.17 -10000 0 -0.39 39 39
PLA2G4A -0.059 0.19 -10000 0 -0.44 33 33
GDI1 -0.046 0.17 -10000 0 -0.39 39 39
TP53 -0.064 0.2 -10000 0 -0.5 32 32
RPS6KA5 -0.055 0.19 -10000 0 -0.43 39 39
ESR1 -0.07 0.22 -10000 0 -0.46 44 44
HBP1 0.022 0.011 -10000 0 -10000 0 0
MEF2C -0.047 0.17 -10000 0 -0.39 39 39
MEF2A -0.048 0.18 -10000 0 -0.4 39 39
EIF4EBP1 -0.054 0.19 -10000 0 -0.43 39 39
KRT19 -0.07 0.19 -10000 0 -0.42 46 46
ELK4 -0.05 0.18 -10000 0 -0.41 39 39
ATF6 -0.05 0.18 -10000 0 -0.41 39 39
ATF1 -0.053 0.19 -10000 0 -0.42 39 39
p38alpha-beta/MAPKAPK2 -0.025 0.2 -10000 0 -0.45 31 31
p38alpha-beta/MAPKAPK3 -0.021 0.19 -10000 0 -0.45 29 29
BMP receptor signaling

Figure S9.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S9.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BMP7/BMPR2/BMPR1A-1B/FS -0.37 0.3 -10000 0 -0.52 153 153
SMAD6-7/SMURF1 0.039 0.041 -10000 0 -0.43 1 1
NOG 0.015 0.068 -10000 0 -0.66 2 2
SMAD9 -0.086 0.18 -10000 0 -0.56 22 22
SMAD4 0.026 0.008 -10000 0 -10000 0 0
SMAD5 -0.18 0.18 -10000 0 -0.32 119 119
BMP7/USAG1 -0.2 0.28 -10000 0 -0.53 84 84
SMAD5/SKI -0.18 0.19 0.25 2 -0.46 30 32
SMAD1 -0.043 0.098 -10000 0 -0.55 4 4
BMP2 0.027 0.006 -10000 0 -10000 0 0
SMAD1/SMAD1/SMAD4 -0.039 0.094 -10000 0 -0.42 6 6
BMPR1A 0.028 0.003 -10000 0 -10000 0 0
BMPR1B -0.37 0.33 -10000 0 -0.65 124 124
BMPR1A-1B/BAMBI -0.23 0.24 -10000 0 -0.43 121 121
AHSG -0.003 0.026 -10000 0 -10000 0 0
CER1 -0.002 0.022 -10000 0 -10000 0 0
BMP2-4/CER1 0.045 0.019 -10000 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA -0.14 0.16 -10000 0 -0.4 29 29
BMP2-4 (homodimer) 0.037 0.014 -10000 0 -10000 0 0
RGMB 0.027 0.005 -10000 0 -10000 0 0
BMP6/BMPR2/BMPR1A-1B -0.2 0.22 -10000 0 -0.4 120 120
RGMA -0.032 0.19 -10000 0 -0.62 19 19
SMURF1 0.023 0.011 -10000 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP -0.15 0.16 -10000 0 -0.38 29 29
BMP2-4/USAG1 -0.049 0.17 -10000 0 -0.43 36 36
SMAD6/SMURF1/SMAD5 -0.16 0.18 -10000 0 -0.48 24 24
SOSTDC1 -0.11 0.25 -10000 0 -0.66 36 36
BMP7/BMPR2/BMPR1A-1B -0.31 0.26 -10000 0 -0.45 151 151
SKI 0.025 0.008 -10000 0 -10000 0 0
BMP6 (homodimer) 0.027 0.006 -10000 0 -10000 0 0
HFE2 0.012 0.023 -10000 0 -10000 0 0
ZFYVE16 0.027 0.005 -10000 0 -10000 0 0
MAP3K7 0.027 0.005 -10000 0 -10000 0 0
BMP2-4/CHRD 0.029 0.097 -10000 0 -0.39 10 10
SMAD5/SMAD5/SMAD4 -0.18 0.19 0.25 2 -0.46 30 32
MAPK1 0.025 0.008 -10000 0 -10000 0 0
TAK1/TAB family -0.11 0.14 -10000 0 -0.36 21 21
BMP7 (homodimer) -0.17 0.3 -10000 0 -0.66 59 59
NUP214 0.026 0.007 -10000 0 -10000 0 0
BMP6/FETUA 0.031 0.019 -10000 0 -10000 0 0
SMAD1/SKI -0.038 0.11 -10000 0 -0.49 6 6
SMAD6 0.024 0.047 -10000 0 -0.66 1 1
CTDSP2 0.027 0.005 -10000 0 -10000 0 0
BMP2-4/FETUA 0.043 0.024 -10000 0 -10000 0 0
MAP3K7IP1 0 0 -10000 0 -10000 0 0
GREM1 -0.12 0.27 -10000 0 -0.64 43 43
BMPR2 (homodimer) 0.028 0.004 -10000 0 -10000 0 0
GADD34/PP1CA 0.055 0.012 -10000 0 -10000 0 0
BMPR1A-1B (homodimer) -0.27 0.26 -10000 0 -0.49 124 124
CHRDL1 -0.24 0.33 -10000 0 -0.66 81 81
ENDOFIN/SMAD1 -0.042 0.11 0.28 1 -0.5 6 7
SMAD6-7/SMURF1/SMAD1 -0.037 0.11 -10000 0 -0.46 7 7
SMAD6/SMURF1 0.023 0.011 -10000 0 -10000 0 0
BAMBI 0.024 0.047 -10000 0 -0.66 1 1
SMURF2 0.026 0.008 -10000 0 -10000 0 0
BMP2-4/CHRDL1 -0.13 0.23 -10000 0 -0.41 81 81
BMP2-4/GREM1 -0.047 0.19 -10000 0 -0.42 41 41
SMAD7 0.026 0.008 -10000 0 -10000 0 0
SMAD8A/SMAD8A/SMAD4 -0.084 0.19 -10000 0 -0.56 24 24
SMAD1/SMAD6 -0.042 0.11 -10000 0 -0.51 6 6
TAK1/SMAD6 0.032 0.018 -10000 0 -10000 0 0
BMP7 -0.17 0.31 -10000 0 -0.66 59 59
BMP6 0.027 0.006 -10000 0 -10000 0 0
MAP3K7IP2 0 0 -10000 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 -0.12 0.14 -10000 0 -0.37 29 29
PPM1A 0.026 0.007 -10000 0 -10000 0 0
SMAD1/SMURF2 -0.043 0.1 -10000 0 -0.51 5 5
SMAD7/SMURF1 0.031 0.019 -10000 0 -10000 0 0
CTDSPL 0.027 0.006 -10000 0 -10000 0 0
PPP1CA 0.028 0.002 -10000 0 -10000 0 0
XIAP 0.028 0 -10000 0 -10000 0 0
CTDSP1 0.027 0.005 -10000 0 -10000 0 0
PPP1R15A 0.028 0.003 -10000 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/FS -0.24 0.28 -10000 0 -0.47 94 94
CHRD -0.005 0.15 -10000 0 -0.66 10 10
BMPR2 0.028 0.004 -10000 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM -0.16 0.16 -10000 0 -0.28 123 123
BMP4 0.026 0.007 -10000 0 -10000 0 0
FST -0.13 0.27 -10000 0 -0.66 45 45
BMP2-4/NOG 0.042 0.051 -10000 0 -0.43 2 2
BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 -0.27 0.24 -10000 0 -0.45 122 122
Endothelins

Figure S10.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S10.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
AKT1 -0.006 0.13 0.25 4 -0.45 9 13
PTK2B 0.026 0.006 -10000 0 -10000 0 0
mol:Ca2+ -0.28 0.44 -10000 0 -0.92 63 63
EDN1 0.028 0.067 -10000 0 -10000 0 0
EDN3 0.011 0.023 -10000 0 -10000 0 0
EDN2 0.002 0.12 -10000 0 -0.58 8 8
HRAS/GDP -0.11 0.21 0.28 2 -0.5 33 35
ETA receptor/Endothelin-1/Gq/GTP/PLC beta -0.084 0.19 -10000 0 -0.43 36 36
ADCY4 -0.031 0.15 -10000 0 -0.44 17 17
ADCY5 -0.026 0.14 -10000 0 -0.41 17 17
ADCY6 -0.007 0.11 -10000 0 -0.38 9 9
ADCY7 -0.005 0.1 -10000 0 -0.39 6 6
ADCY1 -0.13 0.2 -10000 0 -0.39 69 69
ADCY2 -0.025 0.11 -10000 0 -0.4 9 9
ADCY3 -0.007 0.11 -10000 0 -0.38 9 9
ADCY8 -0.01 0.11 -10000 0 -0.38 9 9
ADCY9 -0.004 0.097 -10000 0 -0.39 6 6
arachidonic acid secretion -0.18 0.27 -10000 0 -0.55 53 53
ETB receptor/Endothelin-1/Gq/GTP -0.064 0.16 -10000 0 -0.34 43 43
GNAO1 -0.011 0.15 -10000 0 -0.66 11 11
HRAS 0.027 0.004 -10000 0 -10000 0 0
ETA receptor/Endothelin-1/G12/GTP 0.017 0.13 0.38 8 -0.4 8 16
ETA receptor/Endothelin-1/Gs/GTP 0.02 0.14 0.35 11 -0.39 10 21
mol:GTP -0.003 0.007 -10000 0 -10000 0 0
COL3A1 -0.014 0.16 -10000 0 -0.56 11 11
EDNRB 0.024 0.048 -10000 0 -0.66 1 1
response to oxidative stress 0 0 -10000 0 -10000 0 0
CYSLTR2 -0.025 0.17 -10000 0 -0.57 15 15
CYSLTR1 -0.007 0.14 -10000 0 -0.49 9 9
SLC9A1 0.005 0.082 -10000 0 -0.31 6 6
mol:GDP -0.13 0.22 0.28 2 -0.5 39 41
SLC9A3 -0.6 0.37 -10000 0 -0.72 169 169
RAF1 -0.14 0.23 0.29 1 -0.52 39 40
JUN -0.16 0.28 -10000 0 -0.68 33 33
JAK2 -0.006 0.13 0.25 4 -0.45 9 13
mol:IP3 -0.1 0.2 -10000 0 -0.46 40 40
ETA receptor/Endothelin-1 0.021 0.17 0.44 11 -0.44 16 27
PLCB1 -0.03 0.19 -10000 0 -0.66 17 17
PLCB2 0.011 0.033 -10000 0 -10000 0 0
ETA receptor/Endothelin-3 0.014 0.11 -10000 0 -0.49 8 8
FOS -0.2 0.36 -10000 0 -0.89 39 39
Gai/GDP -0.062 0.25 -10000 0 -0.76 23 23
CRK 0.025 0.008 -10000 0 -10000 0 0
mol:Ca ++ -0.095 0.21 -10000 0 -0.56 24 24
BCAR1 0.026 0.007 -10000 0 -10000 0 0
PRKCB1 -0.11 0.2 -10000 0 -0.44 44 44
GNAQ 0.014 0.023 -10000 0 -10000 0 0
GNAZ 0.025 0.008 -10000 0 -10000 0 0
GNAL 0.023 0.048 -10000 0 -0.66 1 1
Gs family/GDP -0.11 0.2 0.25 1 -0.48 35 36
ETA receptor/Endothelin-1/Gq/GTP -0.087 0.22 -10000 0 -0.48 37 37
MAPK14 -0.071 0.14 -10000 0 -0.41 16 16
TRPC6 -0.3 0.48 -10000 0 -1 63 63
GNAI2 0.027 0.007 -10000 0 -10000 0 0
GNAI3 0.027 0.006 -10000 0 -10000 0 0
GNAI1 0.019 0.048 -10000 0 -0.66 1 1
ETB receptor/Endothelin-1/Gq/GTP/PLC beta -0.07 0.15 -10000 0 -0.35 33 33
ETB receptor/Endothelin-2 0.018 0.1 -10000 0 -0.44 9 9
ETB receptor/Endothelin-3 0.034 0.04 -10000 0 -0.5 1 1
ETB receptor/Endothelin-1 0.039 0.067 -10000 0 -0.58 1 1
MAPK3 -0.18 0.31 -10000 0 -0.76 39 39
MAPK1 -0.2 0.34 -10000 0 -0.83 39 39
Rac1/GDP -0.1 0.2 0.28 2 -0.51 27 29
cAMP biosynthetic process -0.074 0.17 0.29 5 -0.44 21 26
MAPK8 -0.19 0.34 -10000 0 -0.75 43 43
SRC 0.026 0.009 -10000 0 -10000 0 0
ETB receptor/Endothelin-1/Gi/GTP 0 0.077 -10000 0 -0.29 10 10
p130Cas/CRK/Src/PYK2 -0.16 0.26 0.29 2 -0.56 44 46
mol:K + 0 0 -10000 0 -10000 0 0
G12/GDP -0.1 0.2 0.28 2 -0.5 28 30
COL1A2 0.006 0.11 0.32 1 -0.55 2 3
EntrezGene:2778 0 0 -10000 0 -10000 0 0
ETA receptor/Endothelin-2 -0.002 0.15 -10000 0 -0.51 14 14
mol:DAG -0.1 0.2 -10000 0 -0.46 40 40
MAP2K2 -0.16 0.26 0.28 1 -0.59 43 44
MAP2K1 -0.16 0.26 0.28 1 -0.59 42 43
EDNRA -0.002 0.15 0.23 4 -0.68 8 12
positive regulation of muscle contraction 0.028 0.14 0.4 3 -0.41 6 9
Gq family/GDP -0.13 0.26 -10000 0 -0.55 44 44
HRAS/GTP -0.13 0.22 -10000 0 -0.48 43 43
PRKCH -0.11 0.2 -10000 0 -0.48 34 34
RAC1 0.022 0.011 -10000 0 -10000 0 0
PRKCA -0.094 0.2 0.32 1 -0.49 31 32
PRKCB -0.094 0.19 -10000 0 -0.46 31 31
PRKCE -0.11 0.2 -10000 0 -0.48 33 33
PRKCD -0.1 0.19 -10000 0 -0.48 32 32
PRKCG -0.12 0.2 -10000 0 -0.49 35 35
regulation of vascular smooth muscle contraction -0.24 0.41 -10000 0 -1 39 39
PRKCQ -0.11 0.2 -10000 0 -0.49 35 35
PLA2G4A -0.19 0.31 -10000 0 -0.61 53 53
GNA14 -0.12 0.27 -10000 0 -0.65 44 44
GNA15 0.013 0.029 -10000 0 -10000 0 0
GNA12 0.023 0.011 -10000 0 -10000 0 0
GNA11 0.002 0.1 -10000 0 -0.66 5 5
Rac1/GTP 0.017 0.13 0.38 8 -0.42 7 15
MMP1 -0.053 0.23 -10000 0 -0.99 11 11
Arf6 signaling events

Figure S11.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S11.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CENTA1/KIF3B 0.029 0.016 -10000 0 -10000 0 0
ARNO/beta Arrestin1-2 0.026 0.1 -10000 0 -0.8 3 3
EGFR 0.022 0.011 -10000 0 -10000 0 0
EPHA2 0.025 0.008 -10000 0 -10000 0 0
USP6 0.021 0.022 -10000 0 -10000 0 0
IQSEC1 0.027 0.006 -10000 0 -10000 0 0
EGFR/EGFR/EGF/EGF -0.39 0.18 -10000 0 -0.44 187 187
ARRB2 0.008 0.009 -10000 0 -10000 0 0
mol:GTP 0.027 0.049 0.18 13 -10000 0 13
ARRB1 0.028 0.003 -10000 0 -10000 0 0
FBXO8 0.026 0.007 -10000 0 -10000 0 0
TSHR 0.018 0.019 -10000 0 -10000 0 0
EGF -0.57 0.22 -10000 0 -0.64 188 188
somatostatin receptor activity 0 0 0.001 5 -0.001 69 74
ARAP2 0.027 0.006 -10000 0 -10000 0 0
mol:GDP -0.084 0.14 0.25 1 -0.29 44 45
mol:PI-3-4-5-P3 0 0 0.001 5 -0.001 37 42
ITGA2B 0.018 0.026 -10000 0 -10000 0 0
ARF6 0.026 0.007 -10000 0 -10000 0 0
Ephrin A1/EPHA2/NCK1/GIT1 0.059 0.028 -10000 0 -10000 0 0
ADAP1 0.023 0.011 -10000 0 -10000 0 0
KIF13B 0.027 0.006 -10000 0 -10000 0 0
HGF/MET 0.006 0.1 -10000 0 -0.47 9 9
PXN 0.027 0.006 -10000 0 -10000 0 0
ARF6/GTP -0.13 0.15 0.25 5 -0.3 69 74
EGFR/EGFR/EGF/EGF/ARFGEP100 -0.32 0.16 -10000 0 -0.43 138 138
ADRB2 0.02 0.025 -10000 0 -10000 0 0
receptor agonist activity 0 0 0 7 0 63 70
actin filament binding 0 0 0.001 4 -0.001 69 73
SRC 0.026 0.009 -10000 0 -10000 0 0
ITGB3 -0.002 0.13 -10000 0 -0.66 8 8
GNAQ 0.026 0.007 -10000 0 -10000 0 0
EFA6/PI-4-5-P2 0 0.001 0.002 6 -0.001 39 45
ARF6/GDP -0.046 0.14 0.25 3 -0.48 12 15
ARF6/GDP/GULP/ACAP1 -0.064 0.14 0.25 1 -0.39 11 12
alphaIIb/beta3 Integrin/paxillin/GIT1 0.047 0.087 -10000 0 -0.4 7 7
ACAP1 0.014 0.033 -10000 0 -10000 0 0
ACAP2 0.027 0.005 -10000 0 -10000 0 0
LHCGR/beta Arrestin2 0.014 0.02 -10000 0 -10000 0 0
EFNA1 0.027 0.005 -10000 0 -10000 0 0
HGF -0.007 0.14 -10000 0 -0.66 9 9
CYTH3 0.005 0.003 -10000 0 -10000 0 0
CYTH2 0.004 0.12 -10000 0 -0.98 3 3
NCK1 0.027 0.006 -10000 0 -10000 0 0
fibronectin binding 0 0 0 23 0 44 67
endosomal lumen acidification 0 0 0.001 3 -0.001 68 71
microtubule-based process 0 0 -10000 0 -10000 0 0
GULP1 0.028 0.004 -10000 0 -10000 0 0
GNAQ/ARNO 0.018 0.11 -10000 0 -0.91 3 3
mol:Phosphatidic acid 0 0 -10000 0 -10000 0 0
PIP3-E 0 0 -10000 0 0 10 10
MET 0.017 0.024 -10000 0 -10000 0 0
GNA14 -0.11 0.27 -10000 0 -0.64 44 44
GNA15 0.022 0.023 -10000 0 -10000 0 0
GIT1 0.026 0.007 -10000 0 -10000 0 0
mol:PI-4-5-P2 0 0 0.001 7 -0.001 43 50
GNA11 0.011 0.1 -10000 0 -0.66 5 5
LHCGR -0.004 0.03 -10000 0 -10000 0 0
AGTR1 -0.19 0.32 -10000 0 -0.65 67 67
desensitization of G-protein coupled receptor protein signaling pathway 0.014 0.019 -10000 0 -10000 0 0
IPCEF1/ARNO -0.25 0.14 -10000 0 -0.92 3 3
alphaIIb/beta3 Integrin 0.01 0.1 -10000 0 -0.5 8 8
Signaling events mediated by VEGFR1 and VEGFR2

Figure S12.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S12.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
alphaV beta3 Integrin 0.016 0.1 -10000 0 -0.5 8 8
AKT1 -0.062 0.24 0.36 5 -0.59 33 38
PTK2B -0.095 0.27 0.34 1 -0.69 33 34
VEGFR2 homodimer/Frs2 -0.1 0.31 -10000 0 -0.8 35 35
CAV1 0.022 0.013 -10000 0 -10000 0 0
CALM1 0.026 0.007 -10000 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/Frs2 -0.083 0.3 -10000 0 -0.75 34 34
endothelial cell proliferation -0.031 0.25 0.52 9 -0.55 31 40
mol:Ca2+ -0.092 0.26 -10000 0 -0.67 34 34
VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Rac -0.07 0.27 -10000 0 -0.68 34 34
RP11-342D11.1 -0.1 0.26 -10000 0 -0.69 34 34
CDH5 0.026 0.007 -10000 0 -10000 0 0
VEGFA homodimer 0.061 0.027 -10000 0 -10000 0 0
SHC1 0.027 0.005 -10000 0 -10000 0 0
SHC2 0.018 0.069 -10000 0 -0.66 2 2
HRAS/GDP -0.06 0.24 -10000 0 -0.6 34 34
SH2D2A 0.016 0.031 -10000 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/SHP1/eNOS -0.043 0.25 0.32 1 -0.58 34 35
VEGFR2 homodimer/VEGFA homodimer/TsAd -0.086 0.3 -10000 0 -0.74 35 35
VEGFR1 homodimer 0.02 0.066 -10000 0 -0.66 2 2
SHC/GRB2/SOS1 -0.049 0.27 -10000 0 -0.66 34 34
GRB10 -0.09 0.25 -10000 0 -0.65 34 34
PTPN11 0.027 0.006 -10000 0 -10000 0 0
GRB2 0.026 0.008 -10000 0 -10000 0 0
PAK1 0.028 0.003 -10000 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Cadherin/beta catenin -0.054 0.28 -10000 0 -0.7 33 33
HRAS 0.028 0.003 -10000 0 -10000 0 0
VEGF/Rho/ROCK1/Integrin Complex -0.057 0.17 -10000 0 -0.4 33 33
HIF1A 0.026 0.007 -10000 0 -10000 0 0
FRS2 0.027 0.006 -10000 0 -10000 0 0
oxygen and reactive oxygen species metabolic process -0.07 0.27 -10000 0 -0.67 34 34
mol:GTP 0 0 -10000 0 -10000 0 0
FLT4 0.011 0.1 -10000 0 -0.66 5 5
Nck/Pak 0.04 0.009 -10000 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/Fyn -0.083 0.3 -10000 0 -0.76 34 34
mol:GDP -0.057 0.26 -10000 0 -0.64 34 34
mol:NADP -0.044 0.21 0.32 4 -0.5 33 37
eNOS/Hsp90 -0.028 0.2 0.32 3 -0.47 32 35
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
mol:IP3 -0.094 0.26 -10000 0 -0.68 34 34
HIF1A/ARNT 0.038 0.012 -10000 0 -10000 0 0
SHB 0.027 0.006 -10000 0 -10000 0 0
VEGFA 0.027 0.01 -10000 0 -10000 0 0
VEGFC 0.025 0.012 -10000 0 -10000 0 0
FAK1/Vinculin -0.087 0.28 0.41 2 -0.7 33 35
mol:Ca ++ 0 0 -10000 0 -10000 0 0
RHOA 0.027 0.006 -10000 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin -0.082 0.29 -10000 0 -0.67 40 40
PTPN6 0.027 0.007 -10000 0 -10000 0 0
EPAS1 -0.036 0.16 -10000 0 -0.39 35 35
mol:L-citrulline -0.044 0.21 0.32 4 -0.5 33 37
ITGAV 0.028 0.003 -10000 0 -10000 0 0
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/Frs2/GRB2 -0.066 0.28 -10000 0 -0.71 34 34
VEGFR2 homodimer/VEGFA homodimer -0.08 0.3 -10000 0 -0.75 34 34
VEGFR2/3 heterodimer -0.11 0.32 -10000 0 -0.79 38 38
VEGFB 0.028 0.002 -10000 0 -10000 0 0
MAPK11 -0.11 0.28 -10000 0 -0.72 35 35
VEGFR2 homodimer -0.13 0.34 -10000 0 -0.88 36 36
FLT1 0.02 0.067 -10000 0 -0.66 2 2
NEDD4 0.029 0.005 -10000 0 -10000 0 0
MAPK3 -0.085 0.23 0.34 1 -0.61 33 34
MAPK1 -0.088 0.24 0.33 2 -0.61 34 36
VEGFA145/NRP2 0.036 0.038 -10000 0 -0.48 1 1
VEGFR1/2 heterodimer -0.11 0.32 -10000 0 -0.81 36 36
KDR -0.13 0.34 -10000 0 -0.88 36 36
VEGFA165/NRP1/VEGFR2 homodimer -0.072 0.28 -10000 0 -0.7 34 34
SRC 0.026 0.009 -10000 0 -10000 0 0
platelet activating factor biosynthetic process -0.08 0.25 0.37 5 -0.63 33 38
PI3K -0.084 0.28 -10000 0 -0.71 34 34
VEGFR2 homodimer/VEGFA homodimer/NCK1 -0.083 0.3 -10000 0 -0.75 34 34
FES -0.099 0.28 -10000 0 -0.72 34 34
GAB1 -0.088 0.28 -10000 0 -0.73 34 34
VEGFR2 homodimer/VEGFA homodimer/Src -0.08 0.29 -10000 0 -0.74 34 34
CTNNB1 0.027 0.006 -10000 0 -10000 0 0
SOS1 0.027 0.004 -10000 0 -10000 0 0
ARNT 0.027 0.005 -10000 0 -10000 0 0
eNOS/Caveolin-1 -0.04 0.19 0.33 3 -0.49 24 27
VEGFR2 homodimer/VEGFA homodimer/Yes -0.085 0.3 -10000 0 -0.75 34 34
PI3K/GAB1 -0.064 0.24 -10000 0 -0.61 33 33
VEGFR2 homodimer/VEGFA homodimer/Frs2/Nck/Pak -0.055 0.28 -10000 0 -0.7 34 34
PRKACA 0.028 0.002 -10000 0 -10000 0 0
VEGFR2/3 heterodimer/VEGFC homodimer -0.095 0.31 -10000 0 -0.76 37 37
HSP90AA1 0.026 0.008 -10000 0 -10000 0 0
CDC42 -0.098 0.27 -10000 0 -0.71 34 34
actin cytoskeleton reorganization -0.085 0.29 -10000 0 -0.74 35 35
PTK2 -0.1 0.29 -10000 0 -0.76 33 33
EDG1 -0.1 0.26 -10000 0 -0.69 34 34
mol:DAG -0.094 0.26 -10000 0 -0.68 34 34
CaM/Ca2+ -0.074 0.25 -10000 0 -0.63 34 34
MAP2K3 -0.099 0.26 -10000 0 -0.69 33 33
VEGFR2 homodimer/VEGFA homodimer/GRB10/NEDD4 -0.044 0.29 -10000 0 -0.68 34 34
PLCG1 -0.096 0.27 -10000 0 -0.7 34 34
VEGFR2 homodimer/VEGFA homodimer/Src/Shb -0.065 0.28 -10000 0 -0.71 34 34
IQGAP1 0.027 0.004 -10000 0 -10000 0 0
YES1 0.026 0.008 -10000 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/SHP2 -0.083 0.3 -10000 0 -0.75 34 34
VEGFR2 homodimer/VEGFA homodimer/SHP1 -0.084 0.3 -10000 0 -0.75 34 34
cell migration -0.06 0.24 0.32 1 -0.58 33 34
mol:PI-3-4-5-P3 -0.074 0.26 -10000 0 -0.64 34 34
FYN 0.027 0.005 -10000 0 -10000 0 0
VEGFB/NRP1 -0.084 0.26 -10000 0 -0.66 34 34
mol:NO -0.044 0.21 0.32 4 -0.5 33 37
PXN 0.027 0.006 -10000 0 -10000 0 0
HRAS/GTP -0.075 0.23 -10000 0 -0.6 34 34
VEGFR2 homodimer/VEGFA homodimer/GRB10 -0.083 0.27 -10000 0 -0.68 34 34
VHL 0.027 0.006 -10000 0 -10000 0 0
ITGB3 -0.002 0.13 -10000 0 -0.66 8 8
NOS3 -0.056 0.24 0.34 3 -0.58 33 36
VEGFR2 homodimer/VEGFA homodimer/Sck -0.088 0.3 -10000 0 -0.74 36 36
RAC1 0.022 0.011 -10000 0 -10000 0 0
PRKCA -0.091 0.24 -10000 0 -0.64 33 33
PRKCB -0.093 0.24 -10000 0 -0.66 31 31
VCL 0.028 0.003 -10000 0 -10000 0 0
VEGFA165/NRP1 -0.087 0.27 -10000 0 -0.69 34 34
VEGFR1/2 heterodimer/VEGFA homodimer -0.087 0.31 -10000 0 -0.78 34 34
VEGFA165/NRP2 0.036 0.038 -10000 0 -0.48 1 1
MAPKKK cascade -0.066 0.23 -10000 0 -0.58 32 32
NRP2 0.023 0.048 -10000 0 -0.66 1 1
VEGFC homodimer 0.025 0.012 -10000 0 -10000 0 0
NCK1 0.027 0.006 -10000 0 -10000 0 0
ROCK1 0.026 0.007 -10000 0 -10000 0 0
FAK1/Paxillin -0.09 0.28 0.34 1 -0.7 33 34
MAP3K13 -0.099 0.28 -10000 0 -0.73 34 34
PDPK1 -0.073 0.22 -10000 0 -0.58 31 31
Signaling events mediated by Stem cell factor receptor (c-Kit)

Figure S13.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S13.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAP4K1 -0.047 0.16 -10000 0 -0.44 29 29
CRKL -0.046 0.18 -10000 0 -0.46 30 30
HRAS -0.014 0.15 -10000 0 -0.44 11 11
mol:PIP3 -0.036 0.17 -10000 0 -0.42 29 29
SPRED1 0.027 0.005 -10000 0 -10000 0 0
SPRED2 0.028 0.004 -10000 0 -10000 0 0
GAB1 -0.046 0.19 -10000 0 -0.48 30 30
FOXO3 -0.032 0.21 0.28 2 -0.41 40 42
AKT1 -0.034 0.22 0.29 2 -0.44 41 43
BAD -0.032 0.21 0.28 2 -0.42 38 40
megakaryocyte differentiation -0.09 0.22 -10000 0 -0.44 53 53
GSK3B -0.027 0.21 0.38 4 -0.41 40 44
RAF1 -0.013 0.12 -10000 0 -0.37 7 7
SHC1 0.027 0.005 -10000 0 -10000 0 0
STAT3 -0.047 0.18 -10000 0 -0.47 29 29
STAT1 -0.1 0.37 -10000 0 -1 30 30
HRAS/SPRED1 -0.001 0.13 -10000 0 -0.38 8 8
cell proliferation -0.052 0.2 -10000 0 -0.48 32 32
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
TEC 0.027 0.006 -10000 0 -10000 0 0
RPS6KB1 -0.036 0.2 -10000 0 -0.47 31 31
HRAS/SPRED2 -0.001 0.13 -10000 0 -0.39 7 7
LYN/TEC/p62DOK -0.007 0.19 -10000 0 -0.45 30 30
MAPK3 -0.002 0.1 0.34 4 -0.28 4 8
STAP1 -0.24 0.25 -10000 0 -0.4 134 134
GRAP2 0.023 0.017 -10000 0 -10000 0 0
JAK2 -0.096 0.32 -10000 0 -0.88 30 30
STAT1 (dimer) -0.1 0.36 -10000 0 -0.97 30 30
mol:Gleevec 0 0.007 -10000 0 -10000 0 0
GRB2/SOCS1/VAV1 -0.012 0.18 -10000 0 -0.46 24 24
actin filament polymerization -0.053 0.18 -10000 0 -0.47 29 29
LYN 0.027 0.005 -10000 0 -10000 0 0
STAP1/STAT5A (dimer) -0.25 0.28 -10000 0 -0.71 37 37
PIK3R1 0.028 0.004 -10000 0 -10000 0 0
CBL/CRKL/GRB2 -0.018 0.16 -10000 0 -0.41 28 28
PI3K -0.01 0.2 -10000 0 -0.45 29 29
PTEN 0.028 0.003 -10000 0 -10000 0 0
SCF/KIT/EPO/EPOR -0.12 0.43 -10000 0 -1.2 30 30
MAPK8 -0.054 0.2 -10000 0 -0.49 32 32
STAT3 (dimer) -0.046 0.18 -10000 0 -0.46 29 29
positive regulation of transcription 0.002 0.09 0.32 4 -0.24 3 7
mol:GDP -0.017 0.15 -10000 0 -0.41 21 21
PIK3C2B -0.046 0.19 -10000 0 -0.47 30 30
CBL/CRKL -0.032 0.17 -10000 0 -0.43 30 30
FER -0.046 0.19 -10000 0 -0.48 29 29
SH2B3 -0.045 0.18 -10000 0 -0.47 30 30
PDPK1 -0.021 0.15 0.3 4 -0.4 23 27
SNAI2 -0.075 0.22 -10000 0 -0.48 42 42
positive regulation of cell proliferation -0.073 0.28 -10000 0 -0.75 30 30
KITLG 0.021 0.026 -10000 0 -10000 0 0
cell motility -0.073 0.28 -10000 0 -0.75 30 30
PTPN6 0.027 0.011 -10000 0 -10000 0 0
EPOR -0.001 0.14 -10000 0 -1.1 1 1
STAT5A (dimer) -0.06 0.24 -10000 0 -0.63 30 30
SOCS1 0.022 0.048 -10000 0 -0.66 1 1
cell migration 0.052 0.2 0.49 31 -10000 0 31
SOS1 0.027 0.004 -10000 0 -10000 0 0
EPO 0.015 0.022 -10000 0 -10000 0 0
VAV1 0.007 0.06 -10000 0 -0.66 1 1
GRB10 -0.054 0.18 -10000 0 -0.48 29 29
PTPN11 0.027 0.008 -10000 0 -10000 0 0
SCF/KIT -0.048 0.21 -10000 0 -0.5 31 31
GO:0007205 0.001 0.008 -10000 0 -10000 0 0
MAP2K1 -0.005 0.11 0.36 3 -0.32 4 7
CBL 0.027 0.005 -10000 0 -10000 0 0
KIT -0.15 0.47 -10000 0 -1.2 34 34
MAP2K2 -0.007 0.11 0.36 3 -0.32 4 7
SHC/Grb2/SOS1 -0.007 0.18 -10000 0 -0.45 26 26
STAT5A -0.063 0.25 -10000 0 -0.65 30 30
GRB2 0.026 0.008 -10000 0 -10000 0 0
response to radiation -0.073 0.22 -10000 0 -0.46 42 42
SHC/GRAP2 0.035 0.019 -10000 0 -10000 0 0
PTPRO -0.092 0.22 -10000 0 -0.45 53 53
SH2B2 -0.054 0.18 -10000 0 -0.48 29 29
DOK1 0.027 0.008 -10000 0 -10000 0 0
MATK -0.053 0.2 -10000 0 -0.5 31 31
CREBBP 0.027 0.044 -10000 0 -10000 0 0
BCL2 -0.042 0.23 -10000 0 -1.1 6 6
Integrins in angiogenesis

Figure S14.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S14.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR2 homodimer/VEGFA homodimer -0.051 0.2 -10000 0 -0.5 35 35
alphaV beta3 Integrin 0.029 0.094 -10000 0 -0.43 8 8
PTK2 -0.14 0.25 0.53 4 -0.59 30 34
IGF1R 0.027 0.004 -10000 0 -10000 0 0
PI4KB 0.027 0.005 -10000 0 -10000 0 0
MFGE8 0.027 0.004 -10000 0 -10000 0 0
SRC 0.026 0.009 -10000 0 -10000 0 0
CDKN1B -0.16 0.26 -10000 0 -0.53 68 68
VEGFA 0.026 0.009 -10000 0 -10000 0 0
ILK -0.16 0.26 -10000 0 -0.53 68 68
ROCK1 0.026 0.007 -10000 0 -10000 0 0
AKT1 -0.16 0.24 -10000 0 -0.5 67 67
PTK2B -0.066 0.16 -10000 0 -0.38 37 37
alphaV/beta3 Integrin/JAM-A -0.1 0.21 -10000 0 -0.39 73 73
CBL 0.027 0.005 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
alphaV beta3 Integrin/ANGPTL3 -0.28 0.23 -10000 0 -0.43 139 139
IGF-1R heterotetramer/IGF1/IRS1/Shp2 0.047 0.092 -10000 0 -0.4 8 8
VEGF/Rho/ROCK/alphaV/beta3 Integrin -0.13 0.2 -10000 0 -0.5 33 33
alphaV/beta3 Integrin/Syndecan-1 0.028 0.1 -10000 0 -0.43 9 9
PI4KA 0.026 0.008 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1 0.024 0.11 -10000 0 -0.35 15 15
PI4 Kinase 0.037 0.013 -10000 0 -10000 0 0
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
alphaV/beta3 Integrin/Osteopontin 0.023 0.1 -10000 0 -0.43 10 10
RPS6KB1 -0.035 0.09 -10000 0 -0.34 15 15
TLN1 0.027 0.006 -10000 0 -10000 0 0
MAPK3 -0.069 0.14 -10000 0 -0.52 11 11
GPR124 0.024 0.047 -10000 0 -0.66 1 1
MAPK1 -0.071 0.14 -10000 0 -0.49 14 14
PXN 0.027 0.006 -10000 0 -10000 0 0
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
alphaV/beta3 Integrin/Tumstatin 0.009 0.14 -10000 0 -0.48 16 16
cell adhesion -0.22 0.19 -10000 0 -0.36 126 126
ANGPTL3 -0.44 0.31 -10000 0 -0.64 144 144
VEGFR2 homodimer/VEGFA homodimer/Src -0.025 0.17 -10000 0 -0.43 30 30
IGF-1R heterotetramer 0.027 0.004 -10000 0 -10000 0 0
Rac1/GDP 0.017 0.008 -10000 0 -10000 0 0
TGFBR2 0.027 0.006 -10000 0 -10000 0 0
ITGB3 -0.002 0.13 -10000 0 -0.66 8 8
IGF1 0.011 0.1 -10000 0 -0.66 5 5
RAC1 0.022 0.011 -10000 0 -10000 0 0
regulation of cell-matrix adhesion 0.028 0.096 -10000 0 -0.41 9 9
apoptosis 0.028 0.003 -10000 0 -10000 0 0
CD47 0.027 0.005 -10000 0 -10000 0 0
alphaV/beta3 Integrin/CD47 0.031 0.091 -10000 0 -0.41 8 8
VCL 0.028 0.003 -10000 0 -10000 0 0
alphaV/beta3 Integrin/Del1 -0.013 0.17 -10000 0 -0.45 25 25
CSF1 0.023 0.048 -10000 0 -0.66 1 1
PIK3C2A -0.16 0.26 -10000 0 -0.53 68 68
PI4 Kinase/Pyk2 -0.15 0.23 -10000 0 -0.41 84 84
VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin -0.028 0.18 -10000 0 -0.41 38 38
FAK1/Vinculin -0.1 0.21 0.5 4 -0.47 28 32
alphaV beta3/Integrin/ppsTEM5 0.029 0.096 -10000 0 -0.41 9 9
RHOA 0.027 0.006 -10000 0 -10000 0 0
VTN -0.2 0.32 -10000 0 -0.66 68 68
BCAR1 0.026 0.007 -10000 0 -10000 0 0
FGF2 0.027 0.007 -10000 0 -10000 0 0
F11R 0.013 0.004 -10000 0 -10000 0 0
alphaV/beta3 Integrin/Lactadherin 0.031 0.094 -10000 0 -0.43 8 8
alphaV/beta3 Integrin/TGFBR2 0.031 0.091 -10000 0 -0.41 8 8
alphaV/beta3 Integrin/c-FMS/Cbl/Cas 0.06 0.04 -10000 0 -0.4 1 1
HSP90AA1 0.026 0.008 -10000 0 -10000 0 0
alphaV/beta3 Integrin/Talin 0.028 0.087 -10000 0 -0.4 8 8
mol:GDP 0 0 -10000 0 -10000 0 0
FN1 0.021 0.025 -10000 0 -10000 0 0
alphaV/beta3 Integrin/Pyk2 -0.036 0.17 -10000 0 -0.38 37 37
SDC1 0.024 0.048 -10000 0 -0.66 1 1
VAV3 0 0.058 0.36 1 -0.38 1 2
PTPN11 0.027 0.006 -10000 0 -10000 0 0
IRS1 0.015 0.085 -10000 0 -0.58 4 4
FAK1/Paxillin -0.11 0.2 0.33 2 -0.47 28 30
cell migration -0.1 0.18 0.28 4 -0.42 27 31
ITGAV 0.028 0.003 -10000 0 -10000 0 0
PI3K -0.087 0.2 -10000 0 -0.36 71 71
SPP1 0.016 0.072 -10000 0 -0.55 3 3
KDR -0.088 0.26 -10000 0 -0.65 36 36
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
alphaV/beta3 Integrin/Caspase 8 0.028 0.003 -10000 0 -10000 0 0
COL4A3 -0.007 0.15 -10000 0 -0.63 11 11
angiogenesis -0.1 0.18 -10000 0 -0.52 13 13
Rac1/GTP 0.025 0.043 -10000 0 -0.35 1 1
EDIL3 -0.039 0.2 -10000 0 -0.66 19 19
cell proliferation 0.031 0.09 -10000 0 -0.4 8 8
IL4-mediated signaling events

Figure S15.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S15.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.4 0.42 -10000 0 -1.1 31 31
STAT6 (cleaved dimer) -0.4 0.43 -10000 0 -1.1 41 41
IGHG1 -0.14 0.15 -10000 0 -0.37 11 11
IGHG3 -0.39 0.41 -10000 0 -1 40 40
AKT1 -0.18 0.23 -10000 0 -0.75 12 12
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 -0.12 0.16 -10000 0 -0.56 6 6
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 -0.2 0.25 -10000 0 -0.79 15 15
THY1 -0.6 0.64 -10000 0 -1.4 71 71
MYB 0.004 0.042 -10000 0 -10000 0 0
HMGA1 0.024 0.018 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3 -0.23 0.24 -10000 0 -0.63 27 27
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP -0.2 0.25 -10000 0 -0.84 12 12
SP1 0.031 0.01 -10000 0 -10000 0 0
INPP5D 0.024 0.017 -10000 0 -10000 0 0
SOCS5 0.034 0.023 -10000 0 -10000 0 0
STAT6 (dimer)/ETS1 -0.4 0.44 -10000 0 -1.1 39 39
SOCS1 -0.26 0.28 -10000 0 -0.74 30 30
SOCS3 -0.19 0.22 -10000 0 -0.9 3 3
FCER2 -0.31 0.33 -10000 0 -0.83 39 39
PARP14 0.027 0.006 -10000 0 -10000 0 0
CCL17 -0.4 0.42 -10000 0 -1.1 34 34
GRB2 0.026 0.008 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP -0.16 0.21 -10000 0 -0.74 11 11
T cell proliferation -0.39 0.43 -10000 0 -1.1 37 37
IL4R/JAK1 -0.39 0.42 -10000 0 -1.1 34 34
EGR2 -0.46 0.54 -10000 0 -1.4 41 41
JAK2 -0.026 0.042 -10000 0 -10000 0 0
JAK3 0.011 0.043 -10000 0 -10000 0 0
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
JAK1 0.003 0.024 -10000 0 -10000 0 0
COL1A2 -0.11 0.14 -10000 0 -10000 0 0
CCL26 -0.37 0.44 -10000 0 -1.1 32 32
IL4R -0.42 0.45 -10000 0 -1.2 34 34
PTPN6 0.036 0.016 -10000 0 -10000 0 0
IL13RA2 -0.84 0.66 -10000 0 -1.4 122 122
IL13RA1 -0.025 0.044 -10000 0 -10000 0 0
IRF4 -0.082 0.18 -10000 0 -0.82 8 8
ARG1 -0.11 0.14 -10000 0 -0.76 2 2
CBL -0.22 0.23 -10000 0 -0.63 21 21
GTF3A 0.028 0.014 -10000 0 -10000 0 0
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
IL13RA1/JAK2 -0.03 0.059 -10000 0 -10000 0 0
IRF4/BCL6 -0.073 0.17 -10000 0 -0.78 8 8
CD40LG 0.027 0.024 -10000 0 -10000 0 0
MAPK14 -0.22 0.23 -10000 0 -0.65 18 18
mitosis -0.17 0.22 -10000 0 -0.7 12 12
STAT6 -0.45 0.5 -10000 0 -1.3 39 39
SPI1 0.012 0.038 -10000 0 -10000 0 0
RPS6KB1 -0.15 0.22 0.52 1 -0.69 11 12
STAT6 (dimer) -0.45 0.5 -10000 0 -1.3 39 39
STAT6 (dimer)/PARP14 -0.41 0.46 -10000 0 -1.2 38 38
mast cell activation 0.011 0.011 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/DOK2 -0.17 0.2 -10000 0 -0.63 10 10
FRAP1 -0.18 0.23 -10000 0 -0.77 11 11
LTA -0.4 0.42 -10000 0 -1.1 34 34
FES 0.024 0.047 -10000 0 -0.66 1 1
T-helper 1 cell differentiation 0.44 0.48 1.2 39 -10000 0 39
CCL11 -0.46 0.5 -10000 0 -1.3 46 46
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES -0.17 0.2 -10000 0 -0.63 11 11
IL2RG 0.029 0.021 -10000 0 -10000 0 0
IL10 -0.4 0.42 -10000 0 -1.1 34 34
IRS1 0.015 0.085 -10000 0 -0.58 4 4
IRS2 0.026 0.009 -10000 0 -10000 0 0
IL4 -0.1 0.14 -10000 0 -0.93 3 3
IL5 -0.41 0.42 -10000 0 -1.1 35 35
IL4/IL4R/JAK1/IL13RA1/JAK2 -0.35 0.37 -10000 0 -0.94 37 37
COL1A1 -0.14 0.2 -10000 0 -0.9 6 6
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
IL4/IL4R/JAK1 -0.4 0.44 -10000 0 -1.2 32 32
IL2R gamma/JAK3 0.025 0.042 -10000 0 -10000 0 0
TFF3 -0.51 0.56 -10000 0 -1.4 52 52
ALOX15 -0.4 0.42 -10000 0 -1.2 31 31
MYBL1 0.021 0.025 -10000 0 -10000 0 0
T-helper 2 cell differentiation -0.34 0.37 -10000 0 -0.9 41 41
SHC1 0.027 0.005 -10000 0 -10000 0 0
CEBPB 0.026 0.016 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 -0.19 0.25 -10000 0 -0.84 13 13
mol:PI-3-4-5-P3 -0.18 0.23 -10000 0 -0.77 11 11
PI3K -0.18 0.24 -10000 0 -0.82 11 11
DOK2 0.018 0.052 -10000 0 -0.66 1 1
ETS1 0.035 0.019 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 -0.15 0.2 -10000 0 -0.76 9 9
ITGB3 -0.42 0.46 -10000 0 -1.2 37 37
PIGR -0.44 0.48 -10000 0 -1.2 41 41
IGHE 0.038 0.05 0.2 7 -10000 0 7
MAPKKK cascade -0.15 0.2 0.47 1 -0.73 9 10
BCL6 0.026 0.009 -10000 0 -10000 0 0
OPRM1 -0.41 0.42 -10000 0 -1.1 34 34
RETNLB -0.4 0.42 -10000 0 -1.1 33 33
SELP -0.45 0.52 -10000 0 -1.4 36 36
AICDA -0.39 0.4 -10000 0 -1.1 33 33
Signaling events mediated by PTP1B

Figure S16.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S16.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB -0.002 0.14 -10000 0 -0.66 9 9
Jak2/Leptin Receptor -0.18 0.18 -10000 0 -0.49 32 32
PTP1B/AKT1 -0.076 0.11 0.23 3 -0.35 17 20
FYN 0.027 0.005 -10000 0 -10000 0 0
p210 bcr-abl/PTP1B -0.089 0.12 0.22 5 -0.35 23 28
EGFR -0.015 0.018 -10000 0 -10000 0 0
EGF/EGFR -0.32 0.14 0.23 1 -0.39 153 154
CSF1 0.023 0.048 -10000 0 -0.66 1 1
AKT1 0.026 0.008 -10000 0 -10000 0 0
INSR 0.028 0.003 -10000 0 -10000 0 0
PTP1B/N-cadherin -0.097 0.15 0.23 3 -0.43 25 28
Insulin Receptor/Insulin -0.057 0.1 0.25 1 -0.37 7 8
HCK 0.012 0.056 -10000 0 -0.66 1 1
CRK 0.026 0.008 -10000 0 -10000 0 0
TYK2 -0.087 0.11 0.23 3 -0.36 20 23
EGF -0.57 0.22 -10000 0 -0.65 188 188
YES1 0.026 0.008 -10000 0 -10000 0 0
CAV1 -0.15 0.13 0.22 6 -0.38 24 30
TXN 0.02 0.009 -10000 0 -10000 0 0
PTP1B/IRS1/GRB2 -0.095 0.11 -10000 0 -0.38 21 21
cell migration 0.089 0.12 0.35 23 -0.22 5 28
STAT3 0.025 0.008 -10000 0 -10000 0 0
PRLR -0.29 0.34 -10000 0 -0.66 97 97
ITGA2B 0.017 0.026 -10000 0 -10000 0 0
CSF1R 0.021 0.05 -10000 0 -0.66 1 1
Prolactin Receptor/Prolactin -0.21 0.26 -10000 0 -0.5 97 97
FGR 0.02 0.05 -10000 0 -0.66 1 1
PTP1B/p130 Cas -0.088 0.11 0.26 1 -0.35 21 22
Crk/p130 Cas -0.087 0.1 0.27 1 -0.36 17 18
DOK1 -0.08 0.13 0.29 5 -0.38 17 22
JAK2 -0.19 0.2 0.24 1 -0.4 74 75
Jak2/Leptin Receptor/Leptin -0.1 0.12 -10000 0 -0.45 10 10
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
PTPN1 -0.09 0.12 0.22 5 -0.36 23 28
LYN 0.027 0.005 -10000 0 -10000 0 0
CDH2 -0.004 0.14 -10000 0 -0.66 9 9
SRC -0.02 0.1 -10000 0 -0.61 5 5
ITGB3 -0.003 0.13 -10000 0 -0.66 8 8
CAT1/PTP1B -0.19 0.2 0.35 5 -0.47 38 43
CAPN1 0.026 0.003 -10000 0 -10000 0 0
CSK 0.027 0.004 -10000 0 -10000 0 0
PI3K -0.051 0.097 -10000 0 -0.4 4 4
mol:H2O2 -0.005 0.004 -10000 0 -10000 0 0
STAT3 (dimer) -0.093 0.11 -10000 0 -0.44 8 8
negative regulation of transcription -0.19 0.2 0.24 1 -0.39 74 75
FCGR2A 0.023 0.02 -10000 0 -10000 0 0
FER 0.021 0.005 -10000 0 -10000 0 0
alphaIIb/beta3 Integrin 0.007 0.1 -10000 0 -0.5 8 8
BLK 0.017 0.025 -10000 0 -10000 0 0
Insulin Receptor/Insulin/Shc 0.047 0.013 -10000 0 -10000 0 0
RHOA 0.025 0.006 -10000 0 -10000 0 0
LEPR 0.025 0.026 -10000 0 -0.33 1 1
BCAR1 0.026 0.007 -10000 0 -10000 0 0
p210 bcr-abl/Grb2 0.026 0.008 -10000 0 -10000 0 0
mol:NADPH -0.006 0.003 -10000 0 -10000 0 0
TRPV6 -0.14 0.21 0.34 2 -0.52 25 27
PRL -0.011 0.018 -10000 0 -10000 0 0
SOCS3 0.032 0.095 -10000 0 -1.3 1 1
SPRY2 0.024 0.006 -10000 0 -10000 0 0
Insulin Receptor/Insulin/IRS1 0.039 0.062 -10000 0 -0.44 3 3
CSF1/CSF1R -0.088 0.11 -10000 0 -0.38 18 18
Ras protein signal transduction 0.064 0.13 0.48 18 -10000 0 18
IRS1 0.015 0.085 -10000 0 -0.58 4 4
INS -0.012 0.016 -10000 0 -10000 0 0
LEP 0.003 0.031 -10000 0 -10000 0 0
STAT5B -0.12 0.14 0.24 2 -0.41 24 26
STAT5A -0.12 0.14 0.24 2 -0.4 26 28
GRB2 0.026 0.008 -10000 0 -10000 0 0
PDGFB-D/PDGFRB -0.1 0.13 -10000 0 -0.39 25 25
CSN2 -0.077 0.12 -10000 0 -0.63 3 3
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
LAT -0.023 0.1 0.27 1 -0.55 6 7
YBX1 0.028 0.008 -10000 0 -10000 0 0
LCK 0.024 0.017 -10000 0 -10000 0 0
SHC1 0.027 0.005 -10000 0 -10000 0 0
NOX4 -0.06 0.22 -10000 0 -0.65 26 26
Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Figure S17.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S17.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
FOXP3 0.02 0.03 -10000 0 -10000 0 0
NFATC2 0.004 0.18 -10000 0 -0.61 13 13
NFATC3 -0.007 0.11 -10000 0 -0.33 10 10
CD40LG -0.14 0.38 -10000 0 -0.96 30 30
ITCH 0.021 0.051 -10000 0 -10000 0 0
CBLB 0.021 0.051 -10000 0 -10000 0 0
CD4-positive CD25-positive alpha-beta regulatory T cell lineage commitment -0.064 0.23 -10000 0 -0.79 6 6
JUNB 0.028 0.003 -10000 0 -10000 0 0
CaM/Ca2+/Calcineurin A alpha-beta B1 0.028 0.061 -10000 0 -0.32 6 6
T cell anergy 0.014 0.084 -10000 0 -0.41 6 6
TLE4 -0.002 0.13 -10000 0 -0.45 10 10
Jun/NFAT1-c-4/p21SNFT -0.063 0.37 -10000 0 -0.91 29 29
AP-1/NFAT1-c-4 -0.13 0.47 -10000 0 -1.1 33 33
IKZF1 0.003 0.11 -10000 0 -0.45 7 7
T-helper 2 cell differentiation -0.41 0.31 -10000 0 -0.77 58 58
AP-1/NFAT1 -0.03 0.21 -10000 0 -0.48 26 26
CALM1 0.029 0.039 -10000 0 -10000 0 0
EGR2 -0.16 0.49 -10000 0 -1.4 24 24
EGR3 -0.18 0.54 -10000 0 -1.5 29 29
NFAT1/FOXP3 0.02 0.14 -10000 0 -0.44 13 13
EGR1 -0.028 0.19 -10000 0 -0.66 17 17
JUN 0.023 0.021 -10000 0 -10000 0 0
EGR4 0.019 0.019 -10000 0 -10000 0 0
mol:Ca2+ 0.004 0.032 -10000 0 -0.18 6 6
GBP3 0.001 0.13 -10000 0 -0.48 7 7
FOSL1 0.026 0.014 -10000 0 -10000 0 0
NFAT1-c-4/MAF/IRF4 -0.058 0.36 -10000 0 -0.9 28 28
DGKA 0.001 0.13 -10000 0 -0.49 6 6
CREM 0.027 0.005 -10000 0 -10000 0 0
NFAT1-c-4/PPARG -0.071 0.37 -10000 0 -0.92 29 29
CTLA4 -0.006 0.11 -10000 0 -0.42 7 7
NFAT1-c-4 (dimer)/EGR1 -0.098 0.42 -10000 0 -1.1 29 29
NFAT1-c-4 (dimer)/EGR4 -0.073 0.38 -10000 0 -0.94 29 29
FOS -0.075 0.24 -10000 0 -0.61 33 33
IFNG -0.019 0.15 -10000 0 -0.59 5 5
T cell activation -0.071 0.23 -10000 0 -0.65 20 20
MAF 0.026 0.008 -10000 0 -10000 0 0
T-helper 2 cell lineage commitment 0 0 -10000 0 -10000 0 0
activation-induced cell death of T cells 0.079 0.28 0.72 32 -10000 0 32
TNF -0.12 0.36 -10000 0 -0.93 30 30
FASLG -0.18 0.53 -10000 0 -1.3 33 33
TBX21 0.022 0.023 -10000 0 -10000 0 0
BATF3 0.026 0.009 -10000 0 -10000 0 0
PRKCQ 0.019 0.081 -10000 0 -0.66 3 3
PTPN1 0.003 0.13 -10000 0 -0.49 6 6
NFAT1-c-4/ICER1 -0.075 0.37 -10000 0 -0.93 29 29
GATA3 -0.47 0.3 -10000 0 -0.65 155 155
T-helper 1 cell differentiation -0.018 0.15 -10000 0 -0.58 5 5
IL2RA -0.055 0.23 -10000 0 -0.72 8 8
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
CASP3 0 0.13 -10000 0 -0.54 3 3
E2F1 0.001 0.045 -10000 0 -10000 0 0
PPARG 0.026 0.009 -10000 0 -10000 0 0
SLC3A2 0.002 0.13 -10000 0 -0.44 12 12
IRF4 0.017 0.053 -10000 0 -0.66 1 1
PTGS2 -0.18 0.44 -10000 0 -1 39 39
CSF2 -0.14 0.38 -10000 0 -0.98 28 28
JunB/Fra1/NFAT1-c-4 -0.056 0.37 -10000 0 -0.9 29 29
IL4 -0.43 0.33 -10000 0 -0.82 57 57
IL5 -0.14 0.38 -10000 0 -0.97 29 29
IL2 -0.073 0.24 -10000 0 -0.66 20 20
IL3 -0.022 0.14 -10000 0 -0.84 4 4
RNF128 0.009 0.13 -10000 0 -0.74 6 6
NFATC1 -0.079 0.28 -10000 0 -0.72 32 32
CDK4 0.04 0.18 0.5 16 -10000 0 16
PTPRK 0.002 0.13 -10000 0 -0.5 5 5
IL8 -0.14 0.38 -10000 0 -0.96 31 31
POU2F1 0.027 0.006 -10000 0 -10000 0 0
amb2 Integrin signaling

Figure S18.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S18.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
alphaM/beta2 Integrin/proMMP-2 0.024 0.052 -10000 0 -10000 0 0
alphaM/beta2 Integrin/GPIbA 0.021 0.061 -10000 0 -0.48 1 1
alphaM/beta2 Integrin/proMMP-9 0.005 0.073 -10000 0 -0.43 2 2
PLAUR 0.021 0.026 -10000 0 -10000 0 0
HMGB1 0.018 0.031 -10000 0 -10000 0 0
alphaM/beta2 Integrin/Talin 0.023 0.052 -10000 0 -10000 0 0
AGER 0.008 0.042 -10000 0 -10000 0 0
RAP1A 0.027 0.006 -10000 0 -10000 0 0
SELPLG 0.018 0.029 -10000 0 -10000 0 0
mol:LDL 0 0 -10000 0 -10000 0 0
alphaM/beta2 Integrin/RAGE/HMGB1 0.017 0.098 -10000 0 -0.33 6 6
mol:GTP 0 0 -10000 0 -10000 0 0
MMP9 -0.013 0.078 -10000 0 -0.66 2 2
CYR61 0.002 0.12 -10000 0 -0.55 9 9
TLN1 0.027 0.006 -10000 0 -10000 0 0
Rap1/GTP -0.15 0.14 -10000 0 -0.42 30 30
RHOA 0.027 0.006 -10000 0 -10000 0 0
P-selectin oligomer -0.02 0.17 -10000 0 -0.6 16 16
MYH2 -0.22 0.19 -10000 0 -0.58 32 32
MST1R 0.012 0.042 -10000 0 -0.34 1 1
leukocyte activation during inflammatory response -0.035 0.15 -10000 0 -0.39 29 29
APOB -0.019 0.16 -10000 0 -0.66 12 12
mol:GDP 0 0 -10000 0 -10000 0 0
complement component iC3b receptor activity 0 0 -10000 0 -10000 0 0
MMP2 0.025 0.012 -10000 0 -10000 0 0
JAM3 0.027 0.005 -10000 0 -10000 0 0
GP1BA 0.023 0.048 -10000 0 -0.66 1 1
alphaM/beta2 Integrin/CTGF 0.017 0.076 -10000 0 -0.45 3 3
alphaM/beta2 Integrin -0.18 0.16 -10000 0 -0.43 41 41
JAM3 homodimer 0.027 0.005 -10000 0 -10000 0 0
ICAM2 0.026 0.008 -10000 0 -10000 0 0
ICAM1 0.027 0.007 -10000 0 -10000 0 0
phagocytosis triggered by activation of immune response cell surface activating receptor -0.18 0.16 -10000 0 -0.43 39 39
cell adhesion 0.021 0.061 -10000 0 -0.48 1 1
NFKB1 -0.023 0.16 0.35 1 -0.46 18 19
THY1 -0.15 0.3 -10000 0 -0.65 56 56
RhoA/GDP 0.02 0.005 -10000 0 -10000 0 0
Lipoprotein(a) -0.041 0.16 -10000 0 -0.43 32 32
alphaM/beta2 Integrin/LRP/tPA 0.008 0.11 -10000 0 -0.39 11 11
IL6 -0.066 0.24 -10000 0 -0.78 19 19
ITGB2 0.002 0.043 -10000 0 -10000 0 0
elevation of cytosolic calcium ion concentration 0.027 0.067 -10000 0 -0.44 1 1
alphaM/beta2 Integrin/JAM2/JAM3 0.031 0.073 -10000 0 -0.34 3 3
JAM2 0.015 0.085 -10000 0 -0.58 4 4
alphaM/beta2 Integrin/ICAM1 0.038 0.067 -10000 0 -0.37 1 1
alphaM/beta2 Integrin/uPA/Plg -0.21 0.22 -10000 0 -0.41 108 108
RhoA/GTP -0.24 0.2 -10000 0 -0.6 34 34
positive regulation of phagocytosis -0.14 0.12 -10000 0 -0.36 26 26
Ron/MSP 0.025 0.05 -10000 0 -0.36 2 2
alphaM/beta2 Integrin/uPAR/uPA 0.028 0.068 -10000 0 -0.45 1 1
alphaM/beta2 Integrin/uPAR 0.019 0.056 -10000 0 -10000 0 0
PLAU 0.025 0.047 -10000 0 -0.66 1 1
PLAT -0.019 0.17 -10000 0 -0.62 15 15
actin filament polymerization -0.22 0.18 -10000 0 -0.55 32 32
MST1 0.023 0.047 -10000 0 -0.66 1 1
alphaM/beta2 Integrin/lipoprotein(a) -0.033 0.15 -10000 0 -0.39 29 29
TNF -0.029 0.16 0.34 1 -0.6 9 10
RAP1B 0.027 0.006 -10000 0 -10000 0 0
alphaM/beta2 Integrin/uPA 0.022 0.062 -10000 0 -0.48 1 1
fibrinolysis -0.2 0.22 -10000 0 -0.41 108 108
HCK 0.012 0.056 -10000 0 -0.66 1 1
dendritic cell antigen processing and presentation -0.18 0.16 -10000 0 -0.43 39 39
VTN -0.2 0.32 -10000 0 -0.66 68 68
alphaM/beta2 Integrin/CYR61 0.01 0.092 -10000 0 -0.38 7 7
LPA -0.066 0.19 -10000 0 -0.66 20 20
LRP1 0.027 0.005 -10000 0 -10000 0 0
cell migration -0.008 0.065 -10000 0 -0.4 2 2
FN1 0.021 0.025 -10000 0 -10000 0 0
alphaM/beta2 Integrin/Thy1 -0.086 0.2 -10000 0 -0.41 55 55
MPO 0.018 0.024 -10000 0 -10000 0 0
KNG1 -0.39 0.32 -10000 0 -0.66 123 123
RAP1/GDP 0.035 0.011 -10000 0 -10000 0 0
ROCK1 -0.22 0.19 -10000 0 -0.57 32 32
ELA2 0 0 -10000 0 -10000 0 0
PLG -0.37 0.32 -10000 0 -0.65 119 119
CTGF 0.018 0.081 -10000 0 -0.66 3 3
alphaM/beta2 Integrin/Hck 0.016 0.067 -10000 0 -0.48 1 1
ITGAM 0.008 0.038 -10000 0 -10000 0 0
alphaM/beta2 Integrin/P-Selectin/PSGL1 0.01 0.1 -10000 0 -0.37 9 9
HP 0.011 0.032 -10000 0 -10000 0 0
leukocyte adhesion -0.09 0.2 -10000 0 -0.41 52 52
SELP -0.02 0.17 -10000 0 -0.6 16 16
Neurotrophic factor-mediated Trk receptor signaling

Figure S19.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S19.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CRKL 0.026 0.008 -10000 0 -10000 0 0
RAS family/GTP/Tiam1 -0.041 0.11 -10000 0 -0.3 12 12
NT3 (dimer)/TRKC -0.11 0.26 -10000 0 -0.53 55 55
NT3 (dimer)/TRKB -0.2 0.27 -10000 0 -0.46 102 102
SHC/Grb2/SOS1/GAB1/PI3K 0.025 0.022 -10000 0 -10000 0 0
RAPGEF1 0.026 0.007 -10000 0 -10000 0 0
BDNF 0.014 0.035 -10000 0 -10000 0 0
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
DYNLT1 0.027 0.005 -10000 0 -10000 0 0
NTRK1 -0.098 0.26 -10000 0 -0.65 37 37
NTRK2 -0.25 0.33 -10000 0 -0.64 86 86
NTRK3 -0.067 0.24 -10000 0 -0.66 29 29
NT-4/5 (dimer)/TRKB -0.15 0.23 -10000 0 -0.42 87 87
neuron apoptosis 0.12 0.18 0.47 28 -10000 0 28
SHC 2-3/Grb2 -0.13 0.2 -10000 0 -0.52 27 27
SHC1 0.027 0.005 -10000 0 -10000 0 0
SHC2 -0.11 0.18 -10000 0 -0.48 25 25
SHC3 -0.14 0.22 -10000 0 -0.54 34 34
STAT3 (dimer) 0.029 0.029 -10000 0 -0.38 1 1
NT3 (dimer)/TRKA -0.11 0.26 -10000 0 -0.48 62 62
RIN/GDP -0.023 0.12 0.3 8 -0.28 8 16
GIPC1 0.028 0.002 -10000 0 -10000 0 0
KRAS 0.027 0.006 -10000 0 -10000 0 0
DNAJA3 -0.047 0.12 -10000 0 -0.31 33 33
RIN/GTP 0.012 0.006 -10000 0 -10000 0 0
CCND1 0.013 0.063 -10000 0 -0.9 1 1
MAGED1 0.028 0.003 -10000 0 -10000 0 0
PTPN11 0.027 0.006 -10000 0 -10000 0 0
RICS 0 0 -10000 0 -10000 0 0
NT-4/5 (dimer) -0.004 0.034 -10000 0 -10000 0 0
SHC/GRB2/SOS1 0.05 0.019 -10000 0 -10000 0 0
GRB2 0.026 0.008 -10000 0 -10000 0 0
NGF (dimer)/TRKA/MATK -0.054 0.2 -10000 0 -0.44 43 43
TRKA/NEDD4-2 -0.057 0.2 -10000 0 -0.48 38 38
ELMO1 0.022 0.011 -10000 0 -10000 0 0
RhoG/GTP/ELMO1/DOCK1 0.03 0.016 -10000 0 -10000 0 0
NGF 0.009 0.1 -10000 0 -0.66 5 5
HRAS 0.028 0.003 -10000 0 -10000 0 0
DOCK1 0.028 0.003 -10000 0 -10000 0 0
GAB2 0.028 0.003 -10000 0 -10000 0 0
RIT2 -0.014 0.014 -10000 0 -10000 0 0
RIT1 0.027 0.005 -10000 0 -10000 0 0
FRS2 0.027 0.006 -10000 0 -10000 0 0
DNM1 -0.002 0.045 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.026 0.008 -10000 0 -10000 0 0
SH2B1 (homopentamer) 0 0 -10000 0 -10000 0 0
RhoG/GTP -0.04 0.13 -10000 0 -0.31 34 34
mol:GDP -0.044 0.16 0.38 7 -0.39 13 20
NGF (dimer) 0.009 0.1 -10000 0 -0.66 5 5
RhoG/GDP 0.017 0.008 -10000 0 -10000 0 0
RIT1/GDP -0.023 0.12 0.31 7 -0.28 8 15
TIAM1 0.026 0.008 -10000 0 -10000 0 0
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
BDNF (dimer)/TRKB -0.15 0.23 -10000 0 -0.43 84 84
KIDINS220/CRKL/C3G 0.036 0.014 -10000 0 -10000 0 0
SHC/RasGAP 0.039 0.01 -10000 0 -10000 0 0
FRS2 family/SHP2 0.051 0.018 -10000 0 -10000 0 0
SHC/GRB2/SOS1/GAB1 0.061 0.026 -10000 0 -10000 0 0
RIT1/GTP 0.02 0.004 -10000 0 -10000 0 0
NT3 (dimer) -0.082 0.25 -10000 0 -0.66 33 33
RAP1/GDP -0.029 0.085 -10000 0 -0.26 5 5
KIDINS220/CRKL 0.026 0.008 -10000 0 -10000 0 0
BDNF (dimer) 0.014 0.035 -10000 0 -10000 0 0
ubiquitin-dependent protein catabolic process -0.045 0.19 -10000 0 -0.43 40 40
Schwann cell development -0.037 0.033 -10000 0 -10000 0 0
EHD4 0.027 0.005 -10000 0 -10000 0 0
FRS2 family/GRB2/SOS1 0.06 0.027 -10000 0 -10000 0 0
FRS2 family/SHP2/CRK family/C3G/GAB2 0.023 0.035 -10000 0 -10000 0 0
RAP1B 0.027 0.006 -10000 0 -10000 0 0
RAP1A 0.027 0.006 -10000 0 -10000 0 0
CDC42/GTP -0.21 0.25 -10000 0 -0.42 111 111
ABL1 0.026 0.007 -10000 0 -10000 0 0
SH2B family/GRB2/SOS1 0.038 0.013 -10000 0 -10000 0 0
Rap1/GTP -0.074 0.14 -10000 0 -0.46 14 14
STAT3 0.029 0.029 -10000 0 -0.37 1 1
axon guidance -0.21 0.23 -10000 0 -0.4 111 111
MAPK3 -0.069 0.16 -10000 0 -0.4 35 35
MAPK1 -0.075 0.17 -10000 0 -0.4 42 42
CDC42/GDP -0.02 0.12 0.3 8 -0.28 8 16
NTF3 -0.082 0.25 -10000 0 -0.66 33 33
NTF4 -0.004 0.034 -10000 0 -10000 0 0
NGF (dimer)/TRKA/FAIM -0.042 0.19 -10000 0 -0.42 40 40
PI3K 0.04 0.009 -10000 0 -10000 0 0
FRS3 0.027 0.007 -10000 0 -10000 0 0
FAIM 0.027 0.009 -10000 0 -10000 0 0
GAB1 0.027 0.007 -10000 0 -10000 0 0
RASGRF1 -0.053 0.14 -10000 0 -0.33 36 36
SOS1 0.027 0.004 -10000 0 -10000 0 0
MCF2L -0.11 0.22 -10000 0 -0.46 55 55
RGS19 0.026 0.009 -10000 0 -10000 0 0
CDC42 0.026 0.008 -10000 0 -10000 0 0
RAS family/GTP 0.016 0.093 0.31 1 -0.49 2 3
Rac1/GDP -0.026 0.1 0.29 3 -0.28 7 10
NGF (dimer)/TRKA/GRIT -0.056 0.18 -10000 0 -0.43 41 41
neuron projection morphogenesis -0.024 0.13 -10000 0 -0.54 4 4
NGF (dimer)/TRKA/NEDD4-2 -0.045 0.19 -10000 0 -0.43 40 40
MAP2K1 0.01 0.077 0.39 5 -10000 0 5
NGFR 0.013 0.093 -10000 0 -0.66 4 4
NGF (dimer)/TRKA/GIPC/GAIP -0.045 0.14 -10000 0 -0.31 39 39
RAS family/GTP/PI3K 0.023 0.01 -10000 0 -10000 0 0
FRS2 family/SHP2/GRB2/SOS1 0.069 0.032 -10000 0 -10000 0 0
NRAS 0.027 0.006 -10000 0 -10000 0 0
GRB2/SOS1 0.038 0.013 -10000 0 -10000 0 0
PRKCI 0.027 0.005 -10000 0 -10000 0 0
ChemicalAbstracts:146-91-8 0 0 -10000 0 -10000 0 0
RAC1 0.022 0.011 -10000 0 -10000 0 0
PRKCZ 0.025 0.008 -10000 0 -10000 0 0
MAPKKK cascade -0.13 0.26 -10000 0 -0.58 51 51
RASA1 0.027 0.005 -10000 0 -10000 0 0
TRKA/c-Abl -0.055 0.2 -10000 0 -0.49 37 37
SQSTM1 0.025 0.015 -10000 0 -10000 0 0
BDNF (dimer)/TRKB/GIPC -0.12 0.22 -10000 0 -0.4 82 82
NGF (dimer)/TRKA/p62/Atypical PKCs -0.015 0.18 -10000 0 -0.39 37 37
MATK 0.013 0.084 -10000 0 -0.66 3 3
NEDD4L 0.024 0.026 -10000 0 -0.34 1 1
RAS family/GDP -0.042 0.067 -10000 0 -0.23 5 5
NGF (dimer)/TRKA -0.049 0.14 -10000 0 -0.33 36 36
Rac1/GTP -0.053 0.1 -10000 0 -0.31 16 16
FRS2 family/SHP2/CRK family 0.065 0.035 -10000 0 -10000 0 0
Ceramide signaling pathway

Figure S20.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S20.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPHK2 0.009 0.011 -10000 0 -10000 0 0
MAP4K4 0.012 0.049 -10000 0 -0.33 1 1
BAG4 0.027 0.006 -10000 0 -10000 0 0
PKC zeta/ceramide -0.11 0.091 -10000 0 -0.27 42 42
NFKBIA 0.026 0.007 -10000 0 -10000 0 0
BIRC3 0.021 0.025 -10000 0 -10000 0 0
BAX -0.046 0.052 -10000 0 -0.37 3 3
RIPK1 0.027 0.006 -10000 0 -10000 0 0
AKT1 0.018 0.05 0.71 1 -10000 0 1
BAD -0.12 0.084 -10000 0 -0.27 42 42
SMPD1 0.009 0.057 0.22 4 -0.23 5 9
RB1 -0.11 0.085 -10000 0 -0.27 41 41
FADD/Caspase 8 0.013 0.058 -10000 0 -10000 0 0
MAP2K4 -0.1 0.083 0.21 1 -0.26 36 37
NSMAF 0.027 0.005 -10000 0 -10000 0 0
response to UV 0 0 -10000 0 -10000 0 0
RAF1 -0.097 0.084 0.21 1 -0.26 33 34
EGF -0.57 0.22 -10000 0 -0.64 188 188
mol:ceramide -0.12 0.089 -10000 0 -0.29 42 42
MADD 0.028 0.004 -10000 0 -10000 0 0
response to oxidative stress 0 0 -10000 0 -10000 0 0
mol:Free Fatty acid 0.009 0.011 -10000 0 -10000 0 0
ASAH1 0.027 0.006 -10000 0 -10000 0 0
negative regulation of cell cycle -0.11 0.084 -10000 0 -0.27 41 41
cell proliferation -0.089 0.086 -10000 0 -0.35 5 5
BID -0.062 0.2 -10000 0 -0.67 20 20
MAP3K1 -0.11 0.084 -10000 0 -0.27 41 41
EIF2A -0.099 0.084 0.24 1 -0.25 37 38
TRADD 0.026 0.007 -10000 0 -10000 0 0
CRADD 0.027 0.005 -10000 0 -10000 0 0
MAPK3 -0.09 0.081 -10000 0 -10000 0 0
response to heat 0 0 -10000 0 -10000 0 0
MAPK1 -0.1 0.083 -10000 0 -10000 0 0
Cathepsin D/ceramide -0.11 0.088 -10000 0 -0.27 42 42
FADD 0.013 0.041 -10000 0 -10000 0 0
KSR1 -0.11 0.086 0.22 1 -0.27 35 36
MAPK8 -0.11 0.099 -10000 0 -0.27 47 47
PRKRA -0.11 0.086 0.19 1 -0.27 41 42
PDGFA 0.02 0.018 -10000 0 -10000 0 0
TRAF2 0.026 0.007 -10000 0 -10000 0 0
IGF1 0.011 0.1 -10000 0 -0.66 5 5
mol:GD3 0 0 -10000 0 -10000 0 0
ganglioside biosynthetic process -0.12 0.088 -10000 0 -0.29 42 42
CTSD 0.028 0.004 -10000 0 -10000 0 0
regulation of nitric oxide biosynthetic process 0.039 0.01 -10000 0 -10000 0 0
response to radiation 0 0 -10000 0 -10000 0 0
ERK1/PKC delta -0.094 0.092 -10000 0 -0.38 5 5
PRKCD 0.027 0.006 -10000 0 -10000 0 0
PRKCZ 0.025 0.008 -10000 0 -10000 0 0
mol:GW4869 0 0 -10000 0 -10000 0 0
mol:sphingosine 0.009 0.011 -10000 0 -10000 0 0
RelA/NF kappa B1 0.039 0.01 -10000 0 -10000 0 0
mol:glutathione 0 0 -10000 0 -10000 0 0
PAWR 0.027 0.006 -10000 0 -10000 0 0
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD 0.015 0.045 -10000 0 -0.35 1 1
TNFR1A/BAG4/TNF-alpha 0.041 0.054 -10000 0 -0.43 2 2
mol:Sphingosine-1-phosphate 0.009 0.011 -10000 0 -10000 0 0
MAP2K1 -0.094 0.083 -10000 0 -0.25 29 29
mol:C11AG 0 0 -10000 0 -10000 0 0
RELA 0.028 0.002 -10000 0 -10000 0 0
CYCS -0.05 0.041 -10000 0 -0.2 2 2
TNFRSF1A 0.027 0.007 -10000 0 -10000 0 0
NFKB1 0.027 0.006 -10000 0 -10000 0 0
TNFR1A/BAG4 0.038 0.012 -10000 0 -10000 0 0
EIF2AK2 -0.11 0.085 -10000 0 -0.26 41 41
TNF-alpha/TNFR1A/FAN 0.041 0.054 -10000 0 -0.43 2 2
response to hydrogen peroxide 0 0 -10000 0 -10000 0 0
CASP8 0.019 0.081 -10000 0 -0.38 6 6
MAP2K2 -0.094 0.083 -10000 0 -10000 0 0
SMPD3 0.013 0.039 -10000 0 -0.21 1 1
TNF 0.014 0.07 -10000 0 -0.66 2 2
PKC zeta/PAR4 0.036 0.015 -10000 0 -10000 0 0
mol:PHOSPHOCHOLINE 0.2 0.085 0.25 147 -10000 0 147
NF kappa B1/RelA/I kappa B alpha 0.07 0.032 -10000 0 -10000 0 0
AIFM1 -0.067 0.062 -10000 0 -0.17 42 42
BCL2 0.026 0.008 -10000 0 -10000 0 0
S1P1 pathway

Figure S21.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S21.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR2 homodimer/VEGFA homodimer -0.056 0.2 -10000 0 -0.5 35 35
PDGFRB -0.002 0.14 -10000 0 -0.66 9 9
SPHK1 -0.006 0.033 -10000 0 -10000 0 0
mol:S1P -0.007 0.042 -10000 0 -10000 0 0
S1P1/S1P/Gi -0.07 0.18 0.22 1 -0.44 33 34
GNAO1 -0.015 0.15 -10000 0 -0.66 11 11
PDGFB-D/PDGFRB/PLCgamma1 -0.054 0.19 0.49 1 -0.44 27 28
PLCG1 -0.064 0.17 0.23 2 -0.42 30 32
mol:GTP 0 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB -0.002 0.14 -10000 0 -0.66 9 9
GNAI2 0.022 0.018 -10000 0 -10000 0 0
GNAI3 0.021 0.018 -10000 0 -10000 0 0
GNAI1 0.015 0.05 -10000 0 -0.66 1 1
mol:GDP 0 0 -10000 0 -10000 0 0
EDG1 -0.071 0.16 -10000 0 -0.43 35 35
S1P1/S1P -0.057 0.13 -10000 0 -0.35 24 24
negative regulation of cAMP metabolic process -0.068 0.18 0.22 1 -0.42 33 34
MAPK3 -0.081 0.22 0.34 6 -0.56 32 38
calcium-dependent phospholipase C activity -0.001 0.003 -10000 0 -10000 0 0
Rac1/GDP 0.017 0.008 -10000 0 -10000 0 0
RhoA/GDP 0.02 0.005 -10000 0 -10000 0 0
KDR -0.092 0.25 -10000 0 -0.65 36 36
PLCB2 -0.045 0.14 0.3 3 -0.35 12 15
RAC1 0.022 0.011 -10000 0 -10000 0 0
RhoA/GTP -0.048 0.11 -10000 0 -0.34 11 11
receptor internalization -0.058 0.12 -10000 0 -0.33 24 24
PTGS2 -0.14 0.38 0.4 5 -0.9 38 43
Rac1/GTP -0.043 0.1 -10000 0 -0.34 8 8
RHOA 0.027 0.006 -10000 0 -10000 0 0
VEGFA 0.022 0.015 -10000 0 -10000 0 0
negative regulation of T cell proliferation -0.068 0.18 0.22 1 -0.42 33 34
GO:0007205 0 0 -10000 0 -10000 0 0
GNAZ 0.021 0.017 -10000 0 -10000 0 0
MAPK1 -0.1 0.24 -10000 0 -0.58 37 37
S1P1/S1P/PDGFB-D/PDGFRB -0.056 0.17 0.34 1 -0.44 15 16
ABCC1 0.025 0.009 -10000 0 -10000 0 0
Stabilization and expansion of the E-cadherin adherens junction

Figure S22.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S22.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
adherens junction organization 0 0.082 -10000 0 -0.28 16 16
epithelial cell differentiation 0.021 0.11 -10000 0 -0.37 16 16
CYFIP2 0.027 0.005 -10000 0 -10000 0 0
ENAH -0.003 0.13 0.49 9 -10000 0 9
EGFR 0.022 0.011 -10000 0 -10000 0 0
EPHA2 0.025 0.008 -10000 0 -10000 0 0
MYO6 -0.019 0.12 0.34 6 -0.36 16 22
CTNNB1 0.027 0.006 -10000 0 -10000 0 0
ABI1/Sra1/Nap1 0.053 0.016 -10000 0 -10000 0 0
AQP5 -0.071 0.19 -10000 0 -0.58 22 22
CTNND1 0.028 0.002 -10000 0 -10000 0 0
mol:PI-4-5-P2 -0.018 0.12 0.34 7 -0.36 16 23
regulation of calcium-dependent cell-cell adhesion -0.044 0.15 0.35 4 -0.39 25 29
EGF -0.57 0.22 -10000 0 -0.64 188 188
NCKAP1 0.028 0.004 -10000 0 -10000 0 0
AQP3 -0.16 0.27 -10000 0 -0.57 58 58
cortical microtubule organization 0.021 0.11 -10000 0 -0.37 16 16
GO:0000145 -0.017 0.12 0.33 7 -0.34 16 23
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.026 0.12 -10000 0 -0.38 16 16
MLLT4 0.027 0.005 -10000 0 -10000 0 0
ARF6/GDP -0.037 0.079 -10000 0 -0.32 12 12
ARF6 0.026 0.007 -10000 0 -10000 0 0
Ephrin A1/EPHA2/NCK1/GIT1 0.059 0.028 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
VASP -0.013 0.1 0.34 2 -0.33 15 17
PVRL2 0.028 0.003 -10000 0 -10000 0 0
ZYX -0.023 0.11 0.35 3 -0.36 15 18
ARF6/GTP 0.064 0.032 -10000 0 -10000 0 0
CDH1 -0.026 0.18 -10000 0 -0.66 16 16
EGFR/EGFR/EGF/EGF -0.28 0.17 -10000 0 -0.39 135 135
RhoA/GDP 0.023 0.11 -10000 0 -0.36 16 16
actin cytoskeleton organization -0.019 0.12 0.33 6 -0.35 16 22
IGF-1R heterotetramer 0.027 0.004 -10000 0 -10000 0 0
GIT1 0.026 0.007 -10000 0 -10000 0 0
IGF1R 0.027 0.004 -10000 0 -10000 0 0
IGF1 0.011 0.1 -10000 0 -0.66 5 5
DIAPH1 0.037 0.1 -10000 0 -10000 0 0
Wnt receptor signaling pathway -0.021 0.11 0.37 16 -10000 0 16
RHOA 0.027 0.006 -10000 0 -10000 0 0
RhoA/GTP -0.038 0.08 -10000 0 -0.33 13 13
CTNNA1 0.027 0.005 -10000 0 -10000 0 0
VCL -0.02 0.12 0.33 6 -0.36 16 22
EFNA1 0.027 0.005 -10000 0 -10000 0 0
LPP -0.026 0.1 0.34 3 -0.34 16 19
Ephrin A1/EPHA2 0.015 0.11 -10000 0 -0.35 16 16
SEC6/SEC8 -0.036 0.085 -10000 0 -0.34 15 15
MGAT3 -0.045 0.15 0.35 4 -0.4 25 29
HGF/MET -0.005 0.13 -10000 0 -0.37 21 21
HGF -0.007 0.14 -10000 0 -0.66 9 9
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0 0.083 -10000 0 -0.29 16 16
actin cable formation 0.027 0.15 0.55 11 -10000 0 11
KIAA1543 -0.019 0.12 0.33 7 -0.34 17 24
KIFC3 -0.035 0.095 -10000 0 -0.36 16 16
NCK1 0.027 0.006 -10000 0 -10000 0 0
EXOC3 0.027 0.005 -10000 0 -10000 0 0
ACTN1 -0.017 0.12 0.34 7 -0.36 16 23
NCK1/GIT1 0.038 0.012 -10000 0 -10000 0 0
mol:GDP 0.021 0.11 -10000 0 -0.37 16 16
EXOC4 0.023 0.011 -10000 0 -10000 0 0
STX4 -0.035 0.094 -10000 0 -0.36 16 16
PIP5K1C -0.018 0.12 0.34 7 -0.36 16 23
LIMA1 0.027 0.005 -10000 0 -10000 0 0
ABI1 0.027 0.005 -10000 0 -10000 0 0
ROCK1 -0.001 0.15 0.51 10 -10000 0 10
adherens junction assembly 0.002 0.13 0.4 10 -10000 0 10
IGF-1R heterotetramer/IGF1 0.007 0.12 -10000 0 -0.35 21 21
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.04 0.009 -10000 0 -10000 0 0
MET 0.017 0.024 -10000 0 -10000 0 0
PLEKHA7 -0.019 0.12 0.34 7 -0.36 17 24
mol:GTP 0.057 0.027 -10000 0 -10000 0 0
establishment of epithelial cell apical/basal polarity -0.006 0.11 0.31 1 -10000 0 1
cortical actin cytoskeleton stabilization 0 0.082 -10000 0 -0.28 16 16
regulation of cell-cell adhesion -0.019 0.12 0.33 6 -0.35 16 22
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0 0.083 -10000 0 -0.29 16 16
FoxO family signaling

Figure S23.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S23.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
G6PC -0.89 0.6 -10000 0 -1.3 148 148
PLK1 0.046 0.097 -10000 0 -10000 0 0
CDKN1B -0.072 0.12 -10000 0 -0.35 7 7
FOXO3 0.045 0.048 -10000 0 -10000 0 0
KAT2B 0.035 0.008 -10000 0 -10000 0 0
FOXO1/SIRT1 -0.31 0.26 -10000 0 -0.45 147 147
CAT 0.033 0.072 -10000 0 -10000 0 0
CTNNB1 0.027 0.006 -10000 0 -10000 0 0
AKT1 -0.032 0.049 -10000 0 -10000 0 0
FOXO1 -0.33 0.27 -10000 0 -0.48 147 147
MAPK10 0.03 0.075 0.21 6 -10000 0 6
mol:GTP 0.001 0 -10000 0 -10000 0 0
FOXO4 0.054 0.092 0.36 3 -10000 0 3
response to oxidative stress -0.037 0.036 -10000 0 -0.17 5 5
FOXO3A/SIRT1 0.063 0.081 -10000 0 -10000 0 0
XPO1 0.028 0.004 -10000 0 -10000 0 0
EP300 -0.04 0.051 -10000 0 -0.19 5 5
BCL2L11 0.03 0.051 -10000 0 -0.68 1 1
FOXO1/SKP2 -0.3 0.26 -10000 0 -0.44 146 146
mol:GDP -0.037 0.036 -10000 0 -0.17 5 5
RAN 0.028 0.006 -10000 0 -10000 0 0
GADD45A 0.049 0.17 0.36 1 -0.57 12 13
YWHAQ 0.027 0.005 -10000 0 -10000 0 0
FOXO1/14-3-3 family -0.05 0.12 -10000 0 -0.45 10 10
MST1 0.031 0.048 -10000 0 -0.65 1 1
CSNK1D 0.026 0.008 -10000 0 -10000 0 0
CSNK1E 0.025 0.008 -10000 0 -10000 0 0
FOXO4/14-3-3 family -0.014 0.13 -10000 0 -0.61 5 5
YWHAB 0.027 0.006 -10000 0 -10000 0 0
MAPK8 0.025 0.081 0.21 7 -0.23 3 10
MAPK9 0.031 0.075 0.21 7 -10000 0 7
YWHAG 0.023 0.011 -10000 0 -10000 0 0
YWHAE 0.026 0.008 -10000 0 -10000 0 0
YWHAZ 0.027 0.004 -10000 0 -10000 0 0
SIRT1 0.03 0.005 -10000 0 -10000 0 0
SOD2 -0.079 0.14 -10000 0 -0.56 3 3
RBL2 0.055 0.088 -10000 0 -0.76 1 1
RAL/GDP -0.002 0.033 -10000 0 -10000 0 0
CHUK 0.036 0.005 -10000 0 -10000 0 0
Ran/GTP 0.023 0.005 -10000 0 -10000 0 0
CSNK1G2 0.028 0.003 -10000 0 -10000 0 0
RAL/GTP 0.002 0.032 -10000 0 -10000 0 0
CSNK1G1 0.028 0.004 -10000 0 -10000 0 0
FASLG 0.006 0.13 -10000 0 -0.75 6 6
SKP2 0.027 0.004 -10000 0 -10000 0 0
USP7 0.026 0.009 -10000 0 -10000 0 0
IKBKB 0.035 0.008 -10000 0 -10000 0 0
CCNB1 0.034 0.072 -10000 0 -10000 0 0
FOXO1-3a-4/beta catenin -0.063 0.13 0.35 1 -0.41 1 2
proteasomal ubiquitin-dependent protein catabolic process -0.3 0.26 -10000 0 -0.44 146 146
CSNK1A1 0.027 0.005 -10000 0 -10000 0 0
SGK1 0.035 0.007 -10000 0 -10000 0 0
CSNK1G3 0.027 0.005 -10000 0 -10000 0 0
Ran/GTP/Exportin 1 0.04 0.01 -10000 0 -10000 0 0
ZFAND5 0.05 0.085 0.46 1 -10000 0 1
SFN -0.019 0.048 -10000 0 -10000 0 0
CDK2 -0.059 0.063 -10000 0 -0.22 4 4
FOXO3A/14-3-3 -0.004 0.11 -10000 0 -0.61 4 4
CREBBP -0.053 0.06 -10000 0 -0.25 1 1
FBXO32 0.037 0.074 0.42 1 -10000 0 1
BCL6 0.054 0.099 -10000 0 -0.68 2 2
RALB 0.029 0.003 -10000 0 -10000 0 0
RALA 0.023 0.012 -10000 0 -10000 0 0
YWHAH 0.025 0.008 -10000 0 -10000 0 0
Signaling events mediated by the Hedgehog family

Figure S24.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S24.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB2 -0.012 0.12 -10000 0 -0.39 2 2
IHH -0.049 0.23 -10000 0 -0.68 25 25
SHH Np/Cholesterol/GAS1 -0.001 0.085 -10000 0 -0.33 12 12
LRPAP1 0.027 0.005 -10000 0 -10000 0 0
dorsoventral neural tube patterning 0.001 0.085 0.33 12 -10000 0 12
SMO/beta Arrestin2 -0.018 0.15 -10000 0 -0.42 20 20
SMO -0.029 0.15 -10000 0 -0.44 20 20
AKT1 -0.023 0.15 -10000 0 -0.63 7 7
ARRB2 0.025 0.01 -10000 0 -10000 0 0
BOC 0.027 0.005 -10000 0 -10000 0 0
ADRBK1 0.028 0.002 -10000 0 -10000 0 0
heart looping -0.029 0.15 -10000 0 -0.43 20 20
STIL 0.009 0.13 0.26 1 -0.33 6 7
DHH N/PTCH2 0.016 0.1 -10000 0 -0.49 8 8
DHH N/PTCH1 -0.019 0.15 -10000 0 -0.37 32 32
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
DHH -0.002 0.13 -10000 0 -0.66 8 8
PTHLH -0.025 0.15 -10000 0 -0.49 2 2
determination of left/right symmetry -0.029 0.15 -10000 0 -0.43 20 20
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
skeletal system development -0.025 0.15 -10000 0 -0.48 2 2
IHH N/Hhip -0.039 0.19 -10000 0 -0.46 34 34
DHH N/Hhip -0.006 0.16 -10000 0 -0.55 15 15
mol:Cholesterol 0 0 -10000 0 -10000 0 0
heart development -0.029 0.15 -10000 0 -0.43 20 20
pancreas development -0.007 0.14 -10000 0 -0.66 9 9
HHAT 0.027 0.006 -10000 0 -10000 0 0
PI3K 0.04 0.009 -10000 0 -10000 0 0
EntrezGene:84976 0 0 -10000 0 -10000 0 0
GAS1 -0.003 0.14 -10000 0 -0.59 10 10
somite specification -0.029 0.15 -10000 0 -0.43 20 20
SHH Np/Cholesterol/PTCH1 -0.017 0.11 -10000 0 -0.32 20 20
SHH Np/Cholesterol/PTCH2 0.013 0.051 -10000 0 -0.39 3 3
SHH Np/Cholesterol/Megalin -0.031 0.14 -10000 0 -0.41 25 25
SHH 0.002 0.061 -10000 0 -0.5 3 3
catabolic process -0.018 0.14 -10000 0 -0.39 25 25
SMO/Vitamin D3 -0.022 0.13 -10000 0 -0.38 21 21
SHH Np/Cholesterol/Hhip -0.005 0.094 -10000 0 -0.4 11 11
LRP2 -0.047 0.21 -10000 0 -0.66 23 23
receptor-mediated endocytosis -0.054 0.18 -10000 0 -0.55 16 16
SHH Np/Cholesterol/BOC 0.014 0.051 -10000 0 -0.4 3 3
SHH Np/Cholesterol/CDO 0.013 0.052 -10000 0 -0.4 3 3
mesenchymal cell differentiation 0.005 0.094 0.39 11 -10000 0 11
mol:Vitamin D3 0.017 0.14 0.37 1 -0.32 20 21
IHH N/PTCH2 -0.015 0.16 -10000 0 -0.44 25 25
CDON 0.026 0.013 -10000 0 -10000 0 0
IHH N/PTCH1 -0.01 0.14 -10000 0 -0.39 25 25
Megalin/LRPAP1 -0.018 0.17 -10000 0 -0.49 23 23
PTCH2 0.025 0.012 -10000 0 -10000 0 0
SHH Np/Cholesterol 0.006 0.049 -10000 0 -0.39 3 3
PTCH1 -0.018 0.14 -10000 0 -0.39 25 25
HHIP -0.007 0.14 -10000 0 -0.66 9 9
Plasma membrane estrogen receptor signaling

Figure S25.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S25.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GNB1/GNG2 0.037 0.094 -10000 0 -0.38 9 9
ER alpha/Gai/GDP/Gbeta gamma -0.048 0.2 -10000 0 -0.6 20 20
AKT1 -0.03 0.23 -10000 0 -0.8 16 16
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
E2/ER alpha (dimer)/PELP1/Src/PI3K -0.027 0.23 -10000 0 -0.81 16 16
mol:Ca2+ -0.12 0.22 -10000 0 -0.47 51 51
IGF1R 0.027 0.004 -10000 0 -10000 0 0
E2/ER alpha (dimer)/Striatin 0.005 0.12 -10000 0 -0.38 16 16
SHC1 0.027 0.005 -10000 0 -10000 0 0
apoptosis 0.028 0.22 0.76 16 -10000 0 16
RhoA/GTP 0.007 0.072 -10000 0 -0.34 7 7
E2/ER alpha (dimer)/PELP1/Src/p130 Cas -0.016 0.18 -10000 0 -0.55 17 17
regulation of stress fiber formation 0.007 0.093 0.29 2 -0.33 6 8
E2/ERA-ERB (dimer) 0.011 0.098 -10000 0 -0.37 12 12
KRAS 0.027 0.006 -10000 0 -10000 0 0
G13/GTP 0.013 0.083 -10000 0 -0.31 12 12
pseudopodium formation -0.007 0.093 0.33 6 -0.29 2 8
E2/ER alpha (dimer)/PELP1 0.012 0.094 -10000 0 -0.36 12 12
GRB2 0.026 0.008 -10000 0 -10000 0 0
GNG2 0.026 0.007 -10000 0 -10000 0 0
GNAO1 -0.011 0.15 -10000 0 -0.66 11 11
HRAS 0.028 0.003 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
mol:NO -0.016 0.21 0.37 2 -0.57 19 21
E2/ER beta (dimer) 0.019 0.007 -10000 0 -10000 0 0
mol:GDP -0.008 0.1 -10000 0 -0.42 12 12
mol:NADP -0.016 0.21 0.37 2 -0.57 19 21
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
mol:IP3 -0.12 0.23 -10000 0 -0.49 51 51
IGF-1R heterotetramer 0.027 0.004 -10000 0 -10000 0 0
PLCB1 -0.12 0.24 -10000 0 -0.5 52 52
PLCB2 -0.099 0.22 -10000 0 -0.5 45 45
IGF1 0.011 0.1 -10000 0 -0.66 5 5
mol:L-citrulline -0.016 0.21 0.37 2 -0.57 19 21
RHOA 0.027 0.006 -10000 0 -10000 0 0
Gai/GDP -0.035 0.22 -10000 0 -0.68 20 20
JNK cascade 0.019 0.007 -10000 0 -10000 0 0
BCAR1 0.026 0.007 -10000 0 -10000 0 0
ESR2 0.026 0.01 -10000 0 -10000 0 0
GNAQ 0.026 0.007 -10000 0 -10000 0 0
ESR1 -0.007 0.14 -10000 0 -0.58 12 12
Gq family/GDP/Gbeta gamma -0.065 0.2 -10000 0 -0.65 13 13
E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 0.002 0.14 -10000 0 -0.76 5 5
E2/ER alpha (dimer)/PELP1/Src/p52 SHC -0.017 0.18 -10000 0 -0.56 16 16
GNAZ 0.025 0.008 -10000 0 -10000 0 0
E2/ER alpha (dimer) -0.005 0.11 -10000 0 -0.43 12 12
STRN 0.015 0.093 -10000 0 -0.66 4 4
GNAL 0.023 0.048 -10000 0 -0.66 1 1
PELP1 0.026 0.008 -10000 0 -10000 0 0
MAPK11 0.012 0.006 -10000 0 -10000 0 0
GNAI2 0.027 0.007 -10000 0 -10000 0 0
GNAI3 0.027 0.006 -10000 0 -10000 0 0
GNAI1 0.019 0.048 -10000 0 -0.66 1 1
HBEGF -0.025 0.21 0.42 7 -0.55 19 26
cAMP biosynthetic process 0.007 0.084 -10000 0 -0.35 10 10
SRC -0.045 0.19 -10000 0 -0.6 17 17
PI3K 0.04 0.009 -10000 0 -10000 0 0
GNB1 0.025 0.008 -10000 0 -10000 0 0
G13/GDP/Gbeta gamma 0.021 0.1 -10000 0 -0.44 7 7
SOS1 0.027 0.004 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1 -0.042 0.15 -10000 0 -0.46 17 17
Gs family/GTP 0.013 0.087 -10000 0 -0.36 10 10
EntrezGene:2778 0 0 -10000 0 -10000 0 0
RAS family/GTP 0.048 0.017 -10000 0 -10000 0 0
vasodilation -0.013 0.2 0.36 2 -0.54 19 21
mol:DAG -0.12 0.23 -10000 0 -0.49 51 51
Gs family/GDP/Gbeta gamma 0 0.095 -10000 0 -0.4 8 8
MSN -0.008 0.097 0.33 6 -0.32 2 8
Gq family/GTP -0.093 0.23 -10000 0 -0.52 45 45
mol:PI-3-4-5-P3 -0.024 0.22 -10000 0 -0.78 16 16
NRAS 0.027 0.006 -10000 0 -10000 0 0
mol:E2 0 0 -10000 0 -10000 0 0
cell adhesion 0.013 0.2 0.54 19 -0.36 2 21
GRB2/SOS1 0.038 0.013 -10000 0 -10000 0 0
RhoA/GDP 0.009 0.11 -10000 0 -0.4 12 12
NOS3 -0.02 0.22 0.37 2 -0.61 19 21
GNA11 0.012 0.1 -10000 0 -0.66 5 5
MAPKKK cascade -0.014 0.21 0.38 4 -0.65 16 20
E2/ER alpha (dimer)/PELP1/Src -0.022 0.19 -10000 0 -0.57 17 17
ruffle organization -0.007 0.093 0.33 6 -0.29 2 8
ROCK2 -0.006 0.1 0.35 6 -0.33 9 15
GNA14 -0.11 0.27 -10000 0 -0.64 44 44
GNA15 0.022 0.023 -10000 0 -10000 0 0
GNA13 0.026 0.008 -10000 0 -10000 0 0
MMP9 -0.041 0.19 0.38 3 -0.55 19 22
MMP2 -0.029 0.19 -10000 0 -0.56 17 17
LPA4-mediated signaling events

Figure S26.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S26.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ADCY4 -0.032 0.1 -10000 0 -0.43 13 13
ADCY5 -0.032 0.1 -10000 0 -0.43 13 13
ADCY6 -0.006 0.001 -10000 0 -10000 0 0
ADCY7 -0.007 0.007 -10000 0 -10000 0 0
ADCY1 -0.15 0.2 -10000 0 -0.43 73 73
ADCY2 -0.024 0.017 -10000 0 -10000 0 0
ADCY3 -0.006 0.001 -10000 0 -10000 0 0
ADCY8 -0.009 0.006 -10000 0 -10000 0 0
PRKCE 0.007 0.001 -10000 0 -10000 0 0
ADCY9 -0.006 0.002 -10000 0 -10000 0 0
mol:DAG 0 0 -10000 0 -10000 0 0
cAMP biosynthetic process -0.029 0.11 0.3 9 -0.24 15 24
Ephrin A reverse signaling

Figure S27.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S27.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAPKKK cascade -0.005 0.12 -9999 0 -0.43 15 15
EFNA5 -0.022 0.18 -9999 0 -0.66 15 15
FYN -0.032 0.1 -9999 0 -0.4 15 15
neuron projection morphogenesis -0.005 0.12 -9999 0 -0.43 15 15
cell-cell signaling 0 0 -9999 0 -10000 0 0
Ephrin A5/EPHA5 -0.005 0.12 -9999 0 -0.43 15 15
EPHA5 -0.008 0.024 -9999 0 -10000 0 0
Glucocorticoid receptor regulatory network

Figure S28.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S28.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PCK2 0.034 0.1 -10000 0 -0.9 2 2
SMARCC2 0.028 0.006 -10000 0 -10000 0 0
SMARCC1 0.028 0.007 -10000 0 -10000 0 0
TBX21 -0.038 0.075 0.35 2 -10000 0 2
SUMO2 0.018 0.019 -10000 0 -10000 0 0
STAT1 (dimer) 0.032 0.011 -10000 0 -10000 0 0
FKBP4 0.027 0.007 -10000 0 -10000 0 0
FKBP5 0.01 0.1 -10000 0 -0.66 5 5
GR alpha/HSP90/FKBP51/HSP90 0.067 0.088 -10000 0 -0.37 5 5
PRL -0.028 0.068 -10000 0 -10000 0 0
cortisol/GR alpha (dimer)/TIF2 0.082 0.2 0.46 11 -0.45 8 19
RELA -0.079 0.12 -10000 0 -0.28 18 18
FGG 0.083 0.12 0.38 8 -10000 0 8
GR beta/TIF2 0.027 0.16 0.27 3 -0.47 18 21
IFNG -0.091 0.14 -10000 0 -0.55 6 6
apoptosis -0.051 0.22 -10000 0 -0.59 21 21
CREB1 0.017 0.065 -10000 0 -0.36 6 6
histone acetylation -0.025 0.061 -10000 0 -0.28 1 1
BGLAP -0.029 0.065 -10000 0 -10000 0 0
GR/PKAc 0.09 0.058 -10000 0 -10000 0 0
NF kappa B1 p50/RelA -0.14 0.2 -10000 0 -0.44 30 30
SMARCD1 0.028 0.006 -10000 0 -10000 0 0
MDM2 0.041 0.051 0.19 4 -10000 0 4
GATA3 -0.47 0.3 -10000 0 -0.65 155 155
AKT1 0.023 0.019 -10000 0 -10000 0 0
CSF2 -0.029 0.049 -10000 0 -10000 0 0
GSK3B 0.019 0.019 -10000 0 -10000 0 0
NR1I3 -0.061 0.26 -10000 0 -0.78 16 16
CSN2 0.067 0.1 0.32 7 -10000 0 7
BRG1/BAF155/BAF170/BAF60A 0.072 0.022 -10000 0 -10000 0 0
NFATC1 0.027 0.009 -10000 0 -10000 0 0
POU2F1 0.028 0.006 -10000 0 -10000 0 0
CDKN1A 0.014 0.056 -10000 0 -10000 0 0
response to stress 0 0 -10000 0 -10000 0 0
response to UV -0.003 0.006 -10000 0 -10000 0 0
SFN -0.019 0.048 -10000 0 -10000 0 0
GR alpha/HSP90/FKBP51/HSP90/14-3-3 0.058 0.094 -10000 0 -0.35 4 4
prolactin receptor activity 0 0 -10000 0 -10000 0 0
EGR1 -0.074 0.29 0.41 1 -0.8 22 23
JUN -0.069 0.14 -10000 0 -0.44 17 17
IL4 -0.038 0.066 -10000 0 -10000 0 0
CDK5R1 0.025 0.008 -10000 0 -10000 0 0
PRKACA 0.028 0.002 -10000 0 -10000 0 0
cortisol/GR alpha (monomer)/AP-1 -0.052 0.15 0.22 7 -0.39 26 33
GR alpha/HSP90/FKBP51/HSP90/PP5C 0.08 0.086 -10000 0 -0.34 5 5
cortisol/GR alpha (monomer) 0.13 0.17 0.5 13 -10000 0 13
NCOA2 -0.031 0.19 -10000 0 -0.66 18 18
response to hypoxia 0 0 -10000 0 -10000 0 0
FOS -0.076 0.24 -10000 0 -0.6 33 33
AP-1/NFAT1-c-4 -0.12 0.23 -10000 0 -0.6 26 26
AFP -0.16 0.4 -10000 0 -1.3 21 21
SUV420H1 0.028 0.004 -10000 0 -10000 0 0
IRF1 0.077 0.076 -10000 0 -10000 0 0
TP53 0.037 0.016 -10000 0 -10000 0 0
PPP5C 0.028 0.003 -10000 0 -10000 0 0
KRT17 -0.12 0.26 -10000 0 -1 11 11
KRT14 -0.042 0.057 -10000 0 -10000 0 0
TBP 0.033 0.007 -10000 0 -10000 0 0
CREBBP 0.028 0.012 -10000 0 -10000 0 0
HDAC1 0.025 0.007 -10000 0 -10000 0 0
HDAC2 0.027 0.005 -10000 0 -10000 0 0
AP-1 -0.12 0.23 -10000 0 -0.6 26 26
MAPK14 0.019 0.019 -10000 0 -10000 0 0
MAPK10 0.019 0.018 -10000 0 -10000 0 0
MAPK11 0.017 0.019 -10000 0 -10000 0 0
KRT5 -0.1 0.2 -10000 0 -0.97 6 6
interleukin-1 receptor activity -0.001 0.001 -10000 0 -10000 0 0
NCOA1 0.028 0.014 -10000 0 -10000 0 0
STAT1 0.032 0.011 -10000 0 -10000 0 0
CGA -0.071 0.2 -10000 0 -1.2 6 6
NF kappa B1 p50/RelA/Cbp/cortisol/GR alpha (monomer)/HDAC2 0.008 0.061 -10000 0 -10000 0 0
MAPK3 0.019 0.018 -10000 0 -10000 0 0
MAPK1 0.018 0.019 -10000 0 -10000 0 0
ICAM1 -0.14 0.18 -10000 0 -0.49 18 18
NFKB1 -0.074 0.12 -10000 0 -0.28 15 15
MAPK8 -0.07 0.12 -10000 0 -0.39 14 14
MAPK9 0.019 0.018 -10000 0 -10000 0 0
cortisol/GR alpha (dimer) -0.059 0.23 -10000 0 -0.62 21 21
BAX 0.02 0.048 -10000 0 -10000 0 0
POMC -0.19 0.27 -10000 0 -0.77 15 15
EP300 0.028 0.012 -10000 0 -10000 0 0
cortisol/GR alpha (dimer)/p53 0.12 0.15 0.47 10 -10000 0 10
proteasomal ubiquitin-dependent protein catabolic process 0.032 0.078 0.34 10 -10000 0 10
SGK1 0.037 0.071 -10000 0 -10000 0 0
IL13 -0.38 0.26 -10000 0 -0.66 66 66
IL6 -0.19 0.36 -10000 0 -1.2 22 22
PRKACG -0.01 0.018 -10000 0 -10000 0 0
IL5 -0.31 0.21 -10000 0 -0.58 41 41
IL2 -0.099 0.16 -10000 0 -0.64 7 7
CDK5 0.021 0.012 -10000 0 -10000 0 0
PRKACB 0.027 0.007 -10000 0 -10000 0 0
HSP90AA1 0.026 0.008 -10000 0 -10000 0 0
IL8 -0.15 0.19 -10000 0 -0.55 15 15
CDK5R1/CDK5 0.029 0.019 -10000 0 -10000 0 0
NF kappa B1 p50/RelA/PKAc -0.08 0.18 -10000 0 -0.41 16 16
cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 0.11 0.14 0.41 11 -10000 0 11
SMARCA4 0.029 0.003 -10000 0 -10000 0 0
chromatin remodeling 0.084 0.084 0.33 5 -10000 0 5
NF kappa B1 p50/RelA/Cbp -0.078 0.17 -10000 0 -0.43 15 15
JUN (dimer) -0.069 0.14 -10000 0 -0.44 17 17
YWHAH 0.025 0.008 -10000 0 -10000 0 0
VIPR1 -0.079 0.21 0.32 1 -0.96 10 11
NR3C1 0.074 0.097 0.34 6 -10000 0 6
NR4A1 -0.24 0.34 -10000 0 -0.66 84 84
TIF2/SUV420H1 -0.006 0.15 -10000 0 -0.5 18 18
MAPKKK cascade -0.051 0.22 -10000 0 -0.59 21 21
cortisol/GR alpha (dimer)/Src-1 0.12 0.15 0.45 9 -10000 0 9
PBX1 0.018 0.081 -10000 0 -0.66 3 3
POU1F1 0.005 0.023 -10000 0 -10000 0 0
SELE -0.54 0.58 -10000 0 -1.1 102 102
cortisol/GR alpha/BRG1/BAF155/BAF170/BAF60A 0.084 0.085 0.33 5 -10000 0 5
cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 0.11 0.14 0.41 11 -10000 0 11
mol:cortisol 0.06 0.088 0.27 13 -10000 0 13
MMP1 -0.095 0.3 -10000 0 -1.1 16 16
TCR signaling in naïve CD8+ T cells

Figure S29.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S29.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GRB2/SOS1/SHC 0.016 0.09 -10000 0 -10000 0 0
FYN 0.008 0.11 0.35 6 -0.44 3 9
LAT/GRAP2/SLP76 0.02 0.091 0.29 2 -10000 0 2
IKBKB 0.027 0.005 -10000 0 -10000 0 0
AKT1 0.017 0.13 0.35 15 -0.34 5 20
B2M 0.028 0.006 -10000 0 -10000 0 0
IKBKG 0.012 0.047 0.14 7 -10000 0 7
MAP3K8 0.027 0.005 -10000 0 -10000 0 0
mol:Ca2+ -0.058 0.05 -10000 0 -0.11 106 106
integrin-mediated signaling pathway 0.034 0.012 -10000 0 -10000 0 0
LAT/GRAP2/SLP76/VAV1/PI3K Class IA 0.009 0.13 0.38 9 -0.4 6 15
TRPV6 -0.22 0.56 0.81 37 -0.66 115 152
CD28 0.021 0.051 -10000 0 -0.66 1 1
SHC1 0.003 0.1 0.32 3 -0.37 2 5
receptor internalization 0.004 0.098 -10000 0 -0.36 9 9
PRF1 0.016 0.094 -10000 0 -0.57 2 2
KRAS 0.027 0.006 -10000 0 -10000 0 0
GRB2 0.026 0.008 -10000 0 -10000 0 0
COT/AKT1 0.027 0.12 0.33 15 -0.28 4 19
LAT 0.01 0.1 0.36 4 -0.36 5 9
EntrezGene:6955 0.001 0.002 -10000 0 -10000 0 0
CD3D 0.012 0.038 -10000 0 -10000 0 0
CD3E 0.018 0.054 -10000 0 -0.66 1 1
CD3G 0.022 0.024 -10000 0 -10000 0 0
RASGRP2 0.001 0.025 0.11 1 -0.16 3 4
RASGRP1 0.017 0.13 0.38 12 -0.36 7 19
HLA-A 0.027 0.009 -10000 0 -10000 0 0
RASSF5 0.026 0.011 -10000 0 -10000 0 0
RAP1A/GTP/RAPL 0.035 0.012 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
mol:GDP 0.037 0.091 0.3 14 -10000 0 14
PDK1/CARD11/BCL10/MALT1/TRAF6 -0.01 0.039 -10000 0 -10000 0 0
PRKCA 0.007 0.057 0.2 3 -0.25 1 4
GRAP2 0.023 0.017 -10000 0 -10000 0 0
mol:IP3 0.11 0.14 0.25 90 -0.38 1 91
EntrezGene:6957 0.001 0.002 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8 0.014 0.048 -10000 0 -0.3 1 1
ORAI1 0.065 0.37 0.67 4 -0.65 36 40
CSK 0.004 0.098 0.29 3 -0.36 3 6
B7 family/CD28 0.029 0.1 0.28 2 -0.37 1 3
CHUK 0.028 0.003 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8/LCK/ZAP-70 0.002 0.1 0.28 2 -0.39 5 7
PTPN6 0.003 0.1 0.29 3 -0.35 5 8
VAV1 -0.002 0.11 0.3 3 -0.42 5 8
Monovalent TCR/CD3 0.014 0.032 -10000 0 -0.3 1 1
CBL 0.027 0.005 -10000 0 -10000 0 0
LCK 0.004 0.12 0.36 5 -0.4 6 11
PAG1 0.004 0.1 0.3 4 -0.36 3 7
RAP1A 0.027 0.006 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8/LCK 0.002 0.1 0.26 3 -0.38 5 8
CD80 0.014 0.034 -10000 0 -10000 0 0
CD86 0.009 0.039 -10000 0 -10000 0 0
PDK1/CARD11/BCL10/MALT1 -0.005 0.049 -10000 0 -10000 0 0
HRAS 0.028 0.003 -10000 0 -10000 0 0
GO:0035030 -0.004 0.078 0.24 2 -0.33 1 3
CD8A 0.019 0.03 -10000 0 -10000 0 0
CD8B 0.021 0.027 -10000 0 -10000 0 0
PTPRC 0.023 0.049 -10000 0 -0.66 1 1
PDK1/PKC theta 0.024 0.16 0.46 15 -0.4 2 17
CSK/PAG1 0.003 0.093 0.32 2 -0.37 1 3
SOS1 0.027 0.004 -10000 0 -10000 0 0
peptide-MHC class I 0.04 0.014 -10000 0 -10000 0 0
GRAP2/SLP76 0.017 0.097 -10000 0 -0.36 1 1
STIM1 0.056 0.15 -10000 0 -0.77 4 4
RAS family/GTP 0.035 0.087 0.28 13 -0.17 1 14
TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin 0.003 0.1 -10000 0 -0.37 9 9
mol:DAG 0.025 0.081 0.16 2 -0.35 1 3
RAP1A/GDP 0.023 0.049 0.17 12 -10000 0 12
PLCG1 0.027 0.006 -10000 0 -10000 0 0
CD247 0.024 0.02 -10000 0 -10000 0 0
cytotoxic T cell degranulation 0.016 0.092 -10000 0 -0.55 2 2
RAP1A/GTP 0.001 0.009 -10000 0 -0.065 1 1
mol:PI-3-4-5-P3 0.011 0.12 0.37 9 -0.35 6 15
LAT/GRAP2/SLP76/VAV1/PLCgamma1 0.1 0.15 0.27 74 -0.5 1 75
NRAS 0.027 0.006 -10000 0 -10000 0 0
ZAP70 0.016 0.033 -10000 0 -10000 0 0
GRB2/SOS1 0.038 0.013 -10000 0 -10000 0 0
LAT/GRAP2/SLP76/VAV1 0.008 0.093 0.27 2 -0.52 1 3
MALT1 0.026 0.008 -10000 0 -10000 0 0
TRAF6 0.028 0.004 -10000 0 -10000 0 0
CD8 heterodimer 0.031 0.036 -10000 0 -10000 0 0
CARD11 -0.001 0.041 -10000 0 -10000 0 0
PRKCB 0.005 0.052 0.16 1 -0.25 1 2
PRKCE 0.009 0.056 0.22 2 -0.25 1 3
PRKCQ 0.01 0.14 0.42 9 -0.39 5 14
LCP2 0.025 0.015 -10000 0 -10000 0 0
BCL10 0.027 0.007 -10000 0 -10000 0 0
regulation of survival gene product expression 0.018 0.12 0.34 15 -0.3 5 20
IKK complex 0.048 0.13 0.36 20 -10000 0 20
RAS family/GDP 0.001 0.008 -10000 0 -10000 0 0
MAP3K14 0.007 0.066 0.21 7 -0.23 3 10
PDPK1 0.024 0.13 0.4 15 -0.3 4 19
TCR/CD3/MHC I/CD8/Fyn 0.003 0.11 -10000 0 -0.55 2 2
Nongenotropic Androgen signaling

Figure S30.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S30.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 0.006 0.004 -10000 0 -10000 0 0
GNB1/GNG2 0.028 0.091 -10000 0 -0.39 9 9
regulation of S phase of mitotic cell cycle 0.009 0.066 -10000 0 -0.31 8 8
GNAO1 -0.011 0.15 -10000 0 -0.66 11 11
HRAS 0.026 0.009 -10000 0 -10000 0 0
SHBG/T-DHT 0.001 0.079 -10000 0 -0.33 10 10
PELP1 0.025 0.008 -10000 0 -10000 0 0
AKT1 0.007 0.002 -10000 0 -10000 0 0
MAP2K1 -0.027 0.083 -10000 0 -0.34 8 8
T-DHT/AR -0.004 0.1 -10000 0 -0.5 9 9
G-protein coupled receptor activity 0 0 -10000 0 -10000 0 0
mol:GTP -0.001 0.004 -10000 0 -0.009 33 33
GNAI2 0.026 0.007 -10000 0 -10000 0 0
GNAI3 0.027 0.006 -10000 0 -10000 0 0
GNAI1 0.019 0.048 -10000 0 -0.66 1 1
mol:GDP -0.018 0.1 -10000 0 -0.5 9 9
cell proliferation -0.047 0.17 0.37 2 -0.43 25 27
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
FOS -0.12 0.3 0.32 1 -0.81 33 34
mol:Ca2+ -0.005 0.021 -10000 0 -0.07 13 13
MAPK3 -0.022 0.13 0.36 5 -0.49 2 7
MAPK1 -0.051 0.16 -10000 0 -0.48 19 19
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
mol:IP3 -0.001 0.002 -10000 0 -0.005 33 33
cAMP biosynthetic process -0.007 0.083 0.24 6 -0.32 9 15
GNG2 0.026 0.007 -10000 0 -10000 0 0
potassium channel inhibitor activity -0.001 0.002 -10000 0 -0.005 33 33
HRAS/GTP 0.02 0.088 -10000 0 -0.35 9 9
actin cytoskeleton reorganization 0.031 0.02 -10000 0 -10000 0 0
SRC 0.026 0.009 -10000 0 -10000 0 0
voltage-gated calcium channel activity -0.001 0.002 -10000 0 -0.005 33 33
PI3K 0.036 0.008 -10000 0 -10000 0 0
apoptosis 0.051 0.17 0.45 27 -0.28 2 29
T-DHT/AR/PELP1 0.014 0.09 -10000 0 -0.4 9 9
HRAS/GDP -0.003 0.1 -10000 0 -0.48 9 9
CREB1 -0.056 0.19 0.35 1 -0.49 27 28
RAC1-CDC42/GTP 0.038 0.026 -10000 0 -10000 0 0
AR -0.004 0.14 -10000 0 -0.66 9 9
GNB1 0.025 0.008 -10000 0 -10000 0 0
RAF1 -0.008 0.086 -10000 0 -0.35 8 8
RAC1-CDC42/GDP 0.011 0.1 -10000 0 -0.48 8 8
T-DHT/AR/PELP1/Src 0.028 0.089 -10000 0 -0.38 9 9
MAP2K2 -0.028 0.084 -10000 0 -0.34 8 8
T-DHT/AR/PELP1/Src/PI3K 0.009 0.066 -10000 0 -0.31 8 8
GNAZ 0.025 0.008 -10000 0 -10000 0 0
SHBG -0.001 0.12 -10000 0 -0.53 10 10
Gi family/GNB1/GNG2/GDP -0.027 0.15 -10000 0 -0.46 19 19
mol:T-DHT -0.001 0.003 0.001 1 -0.005 30 31
RAC1 0.022 0.011 -10000 0 -10000 0 0
GNRH1 -0.005 0.021 -10000 0 -10000 0 0
Gi family/GTP -0.017 0.073 -10000 0 -0.25 11 11
CDC42 0.026 0.008 -10000 0 -10000 0 0
E-cadherin signaling events

Figure S31.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S31.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
E-cadherin/beta catenin-gamma catenin 0.013 0.13 -9999 0 -0.42 16 16
E-cadherin/beta catenin -0.003 0.14 -9999 0 -0.5 16 16
CTNNB1 0.027 0.006 -9999 0 -10000 0 0
JUP 0.026 0.008 -9999 0 -10000 0 0
CDH1 -0.026 0.18 -9999 0 -0.66 16 16
Caspase cascade in apoptosis

Figure S32.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S32.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TOP1 0.005 0.1 -10000 0 -0.43 9 9
ACTA1 -0.01 0.065 -10000 0 -0.45 2 2
NUMA1 0.003 0.1 -10000 0 -0.43 9 9
SPTAN1 -0.012 0.064 0.27 1 -0.45 2 3
LIMK1 0.023 0.098 0.28 1 -0.45 2 3
BIRC3 0.021 0.025 -10000 0 -10000 0 0
BIRC2 0.027 0.005 -10000 0 -10000 0 0
BAX 0.027 0.008 -10000 0 -10000 0 0
CASP10 -0.014 0.031 -10000 0 -0.43 1 1
CRMA 0 0 -10000 0 -10000 0 0
XIAP 0.028 0 -10000 0 -10000 0 0
PTK2 0 0.14 -10000 0 -0.57 9 9
DIABLO 0.027 0.006 -10000 0 -10000 0 0
apoptotic nuclear changes -0.012 0.064 0.27 1 -0.44 2 3
response to UV 0 0 -10000 0 -10000 0 0
CRADD 0.027 0.005 -10000 0 -10000 0 0
GSN -0.012 0.065 0.27 1 -0.45 2 3
MADD 0.028 0.004 -10000 0 -10000 0 0
TFAP2A -0.42 0.28 -10000 0 -0.53 165 165
BID 0.003 0.017 -10000 0 -0.23 1 1
MAP3K1 0.003 0.059 -10000 0 -0.44 3 3
TRADD 0.026 0.007 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
APAF-1/Pro-Caspase 9 0.036 0.014 -10000 0 -10000 0 0
mol:Activated DNA 0 0 -10000 0 -10000 0 0
ARHGDIB -0.003 0.077 0.28 1 -0.45 2 3
CASP9 0.026 0.008 -10000 0 -10000 0 0
DNA repair 0.001 0.052 0.25 7 -10000 0 7
neuron apoptosis -0.02 0.18 -10000 0 -0.66 14 14
mol:NAD 0 0 -10000 0 -10000 0 0
DNA fragmentation during apoptosis -0.005 0.087 -10000 0 -0.4 7 7
APAF1 0.027 0.006 -10000 0 -10000 0 0
CASP6 -0.003 0.22 -10000 0 -0.96 10 10
TRAF2 0.026 0.007 -10000 0 -10000 0 0
ICAD/CAD -0.012 0.059 -10000 0 -0.44 2 2
CASP7 0.002 0.03 -10000 0 -0.27 1 1
KRT18 0.022 0.04 -10000 0 -10000 0 0
apoptosis -0.013 0.11 -10000 0 -0.49 9 9
DFFA -0.011 0.06 -10000 0 -0.45 2 2
DFFB -0.01 0.062 -10000 0 -0.45 2 2
PARP1 -0.001 0.052 -10000 0 -0.25 7 7
actin filament polymerization -0.022 0.09 0.41 2 -0.26 1 3
TNF 0.014 0.07 -10000 0 -0.66 2 2
CYCS 0.013 0.029 0.18 1 -10000 0 1
SATB1 -0.001 0.21 0.38 4 -0.91 10 14
SLK -0.013 0.062 -10000 0 -0.44 2 2
p15 BID/BAX 0.007 0.046 -10000 0 -10000 0 0
CASP2 0.033 0.091 0.21 32 -0.33 1 33
JNK cascade -0.003 0.059 0.44 3 -10000 0 3
CASP3 -0.011 0.067 -10000 0 -0.47 2 2
LMNB2 0.036 0.14 0.3 8 -0.5 8 16
RIPK1 0.027 0.006 -10000 0 -10000 0 0
CASP4 0.027 0.005 -10000 0 -10000 0 0
Mammalian IAPs/DIABLO 0.066 0.019 -10000 0 -10000 0 0
negative regulation of DNA binding -0.42 0.28 -10000 0 -0.53 165 165
stress fiber formation -0.013 0.061 -10000 0 -0.43 2 2
GZMB 0.004 0.04 -10000 0 -0.5 1 1
CASP1 0.014 0.004 -10000 0 -10000 0 0
LMNB1 0.036 0.14 0.3 8 -0.53 7 15
APP -0.02 0.18 -10000 0 -0.66 14 14
TNFRSF1A 0.027 0.007 -10000 0 -10000 0 0
response to stress 0 0 -10000 0 -10000 0 0
CASP8 0.007 0.001 -10000 0 -10000 0 0
VIM -0.01 0.11 -10000 0 -0.49 10 10
LMNA 0.033 0.16 0.3 8 -0.62 7 15
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD/PIDD 0.009 0.058 -10000 0 -0.26 5 5
LRDD 0 0 -10000 0 -10000 0 0
SREBF1 -0.002 0.079 0.28 1 -0.45 2 3
APAF-1/Caspase 9 -0.022 0.16 -10000 0 -0.6 15 15
nuclear fragmentation during apoptosis 0.003 0.1 -10000 0 -0.42 9 9
CFL2 0.022 0.091 0.26 1 -0.42 2 3
GAS2 -0.02 0.084 -10000 0 -0.44 6 6
positive regulation of apoptosis 0.038 0.15 0.31 8 -0.5 10 18
PRF1 0.025 0.017 -10000 0 -10000 0 0
Noncanonical Wnt signaling pathway

Figure S33.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S33.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC2 -0.018 0.16 -9999 0 -0.66 13 13
GNB1/GNG2 0.022 0.092 -9999 0 -0.43 1 1
mol:DAG -0.002 0.071 -9999 0 -0.4 1 1
PLCG1 -0.002 0.073 -9999 0 -0.42 1 1
YES1 -0.009 0.075 -9999 0 -0.45 1 1
FZD3 0.027 0.006 -9999 0 -10000 0 0
FZD6 0.027 0.004 -9999 0 -10000 0 0
G protein 0.023 0.086 -9999 0 -0.42 1 1
MAP3K7 -0.16 0.16 -9999 0 -0.33 89 89
mol:Ca2+ -0.002 0.07 -9999 0 -0.39 1 1
mol:IP3 -0.002 0.071 -9999 0 -0.4 1 1
NLK 0.004 0.013 -9999 0 -10000 0 0
GNB1 0.025 0.008 -9999 0 -10000 0 0
CAMK2A -0.17 0.18 -9999 0 -0.35 93 93
MAP3K7IP1 0 0 -9999 0 -10000 0 0
Noncanonical Wnts/FZD 0.001 0.081 -9999 0 -0.3 12 12
CSNK1A1 0.027 0.005 -9999 0 -10000 0 0
GNAS -0.009 0.07 -9999 0 -0.45 1 1
GO:0007205 -0.011 0.068 -9999 0 -0.4 1 1
WNT6 0.019 0.049 -9999 0 -0.66 1 1
WNT4 0.012 0.094 -9999 0 -0.66 4 4
NFAT1/CK1 alpha -0.003 0.12 -9999 0 -0.42 1 1
GNG2 0.026 0.007 -9999 0 -10000 0 0
WNT5A 0.011 0.036 -9999 0 -10000 0 0
WNT11 -0.001 0.13 -9999 0 -0.66 8 8
CDC42 -0.006 0.074 -9999 0 -0.43 1 1
Signaling events regulated by Ret tyrosine kinase

Figure S34.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S34.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 0.002 0.077 -10000 0 -0.42 3 3
Crk/p130 Cas/Paxillin -0.026 0.1 -10000 0 -0.34 12 12
JUN -0.024 0.11 -10000 0 -0.46 6 6
HRAS 0.028 0.003 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/GRB10 0.009 0.13 -10000 0 -0.41 17 17
RAP1A 0.027 0.006 -10000 0 -10000 0 0
FRS2 0.027 0.006 -10000 0 -10000 0 0
RAP1A/GDP 0.02 0.004 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/DOK1 0.015 0.15 -10000 0 -0.42 21 21
EntrezGene:5979 0 0 -10000 0 -10000 0 0
PTPN11 0.027 0.006 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.026 0.008 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/Enigma 0.017 0.11 -10000 0 -0.4 13 13
RHOA 0.027 0.006 -10000 0 -10000 0 0
RAP1A/GTP 0.013 0.13 -10000 0 -0.37 21 21
GRB7 0.026 0.008 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF 0.016 0.15 -10000 0 -0.42 21 21
MAPKKK cascade -0.005 0.12 -10000 0 -0.37 18 18
BCAR1 0.026 0.007 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/IRS1 0.009 0.13 -10000 0 -0.43 15 15
lamellipodium assembly -0.017 0.094 -10000 0 -0.32 12 12
RET51/GFRalpha1/GDNF/SHC 0.014 0.15 -10000 0 -0.42 21 21
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/SHC 0.017 0.11 -10000 0 -0.4 13 13
RET9/GFRalpha1/GDNF/Shank3 0.015 0.11 -10000 0 -0.39 13 13
MAPK3 -0.047 0.1 -10000 0 -0.35 21 21
DOK1 0.027 0.008 -10000 0 -10000 0 0
DOK6 -0.067 0.23 -10000 0 -0.63 30 30
PXN 0.027 0.006 -10000 0 -10000 0 0
neurite development -0.057 0.12 -10000 0 -0.45 9 9
DOK5 0.016 0.081 -10000 0 -0.66 3 3
GFRA1 -0.017 0.16 -10000 0 -0.66 13 13
MAPK8 -0.023 0.11 -10000 0 -0.44 8 8
HRAS/GTP 0.012 0.14 -10000 0 -0.41 20 20
tube development 0.024 0.1 -10000 0 -0.38 10 10
MAPK1 -0.037 0.12 0.34 2 -0.35 21 23
RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 0.002 0.07 -10000 0 -0.29 10 10
Rac1/GDP 0.017 0.008 -10000 0 -10000 0 0
SRC 0.026 0.009 -10000 0 -10000 0 0
PDLIM7 0.027 0.006 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/Dok6 -0.033 0.2 -10000 0 -0.42 41 41
SHC1 0.027 0.005 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/Dok4 0.014 0.14 -10000 0 -0.41 21 21
RET51/GFRalpha1/GDNF/Dok5 0.009 0.15 -10000 0 -0.41 23 23
PRKCA 0.026 0.008 -10000 0 -10000 0 0
HRAS/GDP 0.021 0.002 -10000 0 -10000 0 0
CREB1 -0.006 0.097 -10000 0 -0.36 12 12
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 0 0.078 -10000 0 -0.32 11 11
RET51/GFRalpha1/GDNF/Grb7 0.015 0.14 -10000 0 -0.41 19 19
mol:GDP 0 0 -10000 0 -10000 0 0
RET -0.003 0.14 -10000 0 -0.66 9 9
DOK4 0.026 0.007 -10000 0 -10000 0 0
JNK cascade -0.024 0.11 -10000 0 -0.45 6 6
RET9/GFRalpha1/GDNF/FRS2 0.016 0.11 -10000 0 -0.4 13 13
SHANK3 0.025 0.009 -10000 0 -10000 0 0
RASA1 0.027 0.005 -10000 0 -10000 0 0
NCK1 0.027 0.006 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 0.002 0.071 -10000 0 -0.29 9 9
RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.007 0.099 -10000 0 -0.31 18 18
RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK -0.011 0.11 -10000 0 -0.32 20 20
RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.009 0.1 -10000 0 -0.32 18 18
PI3K -0.022 0.15 -10000 0 -0.49 13 13
SOS1 0.027 0.004 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/Shank3/Grb2 0.027 0.098 -10000 0 -0.38 10 10
GRB10 0.023 0.011 -10000 0 -10000 0 0
activation of MAPKK activity 0 0.089 -10000 0 -0.32 9 9
RET51/GFRalpha1/GDNF/FRS2 0.015 0.14 -10000 0 -0.42 20 20
GAB1 0.027 0.007 -10000 0 -10000 0 0
IRS1 0.015 0.085 -10000 0 -0.58 4 4
IRS2 0.026 0.009 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.012 0.11 -10000 0 -0.34 20 20
RET51/GFRalpha1/GDNF/PKC alpha 0.015 0.14 -10000 0 -0.41 19 19
GRB2 0.026 0.008 -10000 0 -10000 0 0
PRKACA 0.028 0.002 -10000 0 -10000 0 0
GDNF -0.008 0.02 -10000 0 -10000 0 0
RAC1 0.022 0.011 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/IRS1 0.008 0.16 -10000 0 -0.44 23 23
Rac1/GTP -0.015 0.11 -10000 0 -0.38 12 12
RET9/GFRalpha1/GDNF 0.001 0.11 -10000 0 -0.43 13 13
GFRalpha1/GDNF -0.001 0.13 -10000 0 -0.5 13 13
Syndecan-3-mediated signaling events

Figure S35.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S35.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CTTN 0.028 0.004 -9999 0 -10000 0 0
Syndecan-3/Src/Cortactin -0.052 0.18 -9999 0 -0.37 46 46
Syndecan-3/Neurocan -0.005 0.1 -9999 0 -0.36 16 16
POMC 0.019 0.071 -9999 0 -0.55 3 3
EGFR 0.022 0.011 -9999 0 -10000 0 0
Syndecan-3/EGFR -0.004 0.1 -9999 0 -0.35 16 16
AGRP 0.013 0.021 -9999 0 -10000 0 0
NCSTN 0.027 0.006 -9999 0 -10000 0 0
PSENEN 0.028 0.003 -9999 0 -10000 0 0
RP11-540L11.1 0 0 -9999 0 -10000 0 0
APH1B 0.024 0.047 -9999 0 -0.66 1 1
APH1A 0.027 0.005 -9999 0 -10000 0 0
NCAN 0.005 0.035 -9999 0 -10000 0 0
long-term memory 0.018 0.1 -9999 0 -0.33 16 16
Syndecan-3/IL8 -0.011 0.1 -9999 0 -0.35 17 17
PSEN1 0.026 0.007 -9999 0 -10000 0 0
Src/Cortactin 0.038 0.012 -9999 0 -10000 0 0
FYN 0.027 0.005 -9999 0 -10000 0 0
limb bud formation -0.01 0.094 -9999 0 -0.38 13 13
MC4R -0.007 0.021 -9999 0 -10000 0 0
SRC 0.026 0.009 -9999 0 -10000 0 0
PTN -0.1 0.26 -9999 0 -0.66 39 39
FGFR/FGF/Syndecan-3 -0.01 0.095 -9999 0 -0.38 13 13
neuron projection morphogenesis -0.047 0.18 -9999 0 -0.42 16 16
Syndecan-3/AgRP -0.001 0.1 -9999 0 -0.36 15 15
Syndecan-3/AgRP/MC4R 0.008 0.1 -9999 0 -0.34 15 15
Fyn/Cortactin 0.04 0.008 -9999 0 -10000 0 0
SDC3 -0.01 0.095 -9999 0 -0.38 13 13
GO:0007205 0 0 -9999 0 -10000 0 0
positive regulation of leukocyte migration -0.011 0.1 -9999 0 -0.35 17 17
IL8 0.001 0.062 -9999 0 -0.66 1 1
Syndecan-3/Fyn/Cortactin 0.019 0.1 -9999 0 -0.34 16 16
Syndecan-3/CASK -0.015 0.097 -9999 0 -0.35 16 16
alpha-MSH/MC4R 0.025 0.057 -9999 0 -0.42 3 3
Gamma Secretase 0.073 0.04 -9999 0 -0.38 1 1
Coregulation of Androgen receptor activity

Figure S36.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S36.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NRIP1 0.026 0.012 -9999 0 -10000 0 0
SVIL 0.027 0.009 -9999 0 -10000 0 0
ZNF318 0.027 0.013 -9999 0 -10000 0 0
JMJD2C 0.001 0.005 -9999 0 -10000 0 0
T-DHT/AR/Ubc9 -0.061 0.11 -9999 0 -0.46 9 9
CARM1 0.028 0.004 -9999 0 -10000 0 0
PRDX1 0.026 0.007 -9999 0 -10000 0 0
PELP1 0.026 0.008 -9999 0 -10000 0 0
CTNNB1 0.026 0.009 -9999 0 -10000 0 0
AKT1 0.026 0.009 -9999 0 -10000 0 0
PTK2B 0.027 0.006 -9999 0 -10000 0 0
MED1 0.026 0.009 -9999 0 -10000 0 0
MAK 0.022 0.024 -9999 0 -10000 0 0
response to oxidative stress 0 0.001 -9999 0 -10000 0 0
HIP1 0.019 0.049 -9999 0 -0.66 1 1
GSN 0.026 0.011 -9999 0 -10000 0 0
NCOA2 -0.031 0.19 -9999 0 -0.66 18 18
NCOA6 0.026 0.01 -9999 0 -10000 0 0
DNA-PK 0.05 0.022 -9999 0 -10000 0 0
NCOA4 0.027 0.005 -9999 0 -10000 0 0
PIAS3 0.027 0.009 -9999 0 -10000 0 0
cell proliferation -0.043 0.11 -9999 0 -0.49 10 10
XRCC5 0.027 0.005 -9999 0 -10000 0 0
UBE3A 0.027 0.01 -9999 0 -10000 0 0
T-DHT/AR/SNURF -0.09 0.14 -9999 0 -0.46 22 22
FHL2 -0.038 0.078 -9999 0 -10000 0 0
RANBP9 0.027 0.009 -9999 0 -10000 0 0
JMJD1A -0.086 0.071 -9999 0 -0.14 138 138
CDK6 0.023 0.011 -9999 0 -10000 0 0
TGFB1I1 0.016 0.081 -9999 0 -0.66 3 3
T-DHT/AR/CyclinD1 -0.066 0.11 -9999 0 -0.46 10 10
XRCC6 0.026 0.009 -9999 0 -10000 0 0
T-DHT/AR -0.12 0.14 -9999 0 -0.49 9 9
CTDSP1 0.027 0.007 -9999 0 -10000 0 0
CTDSP2 0.027 0.009 -9999 0 -10000 0 0
BRCA1 0.024 0.016 -9999 0 -10000 0 0
TCF4 0.025 0.008 -9999 0 -10000 0 0
CDKN2A -0.049 0.041 -9999 0 -10000 0 0
SRF 0.032 0.01 -9999 0 -10000 0 0
NKX3-1 -0.15 0.14 -9999 0 -0.45 10 10
KLK3 0.009 0.1 -9999 0 -1.3 1 1
TMF1 0.026 0.007 -9999 0 -10000 0 0
HNRNPA1 0.027 0.007 -9999 0 -10000 0 0
AOF2 0 0.005 -9999 0 -0.068 1 1
APPL1 0.012 0.009 -9999 0 -10000 0 0
T-DHT/AR/Caspase 8 -0.063 0.11 -9999 0 -0.46 9 9
AR -0.067 0.14 -9999 0 -0.68 9 9
UBA3 0.026 0.008 -9999 0 -10000 0 0
PATZ1 0.025 0.01 -9999 0 -10000 0 0
PAWR 0.027 0.007 -9999 0 -10000 0 0
PRKDC 0.027 0.005 -9999 0 -10000 0 0
PA2G4 0.027 0.008 -9999 0 -10000 0 0
UBE2I 0.025 0.008 -9999 0 -10000 0 0
T-DHT/AR/Cyclin D3/CDK11 p58 -0.054 0.098 -9999 0 -0.42 9 9
RPS6KA3 0.028 0.009 -9999 0 -10000 0 0
T-DHT/AR/ARA70 -0.064 0.11 -9999 0 -0.46 9 9
LATS2 0.027 0.008 -9999 0 -10000 0 0
T-DHT/AR/PRX1 -0.056 0.098 -9999 0 -0.42 9 9
Cyclin D3/CDK11 p58 0.02 0.005 -9999 0 -10000 0 0
VAV3 0.027 0.009 -9999 0 -10000 0 0
KLK2 -0.055 0.063 -9999 0 -0.4 1 1
CASP8 0.028 0.004 -9999 0 -10000 0 0
T-DHT/AR/TIF2/CARM1 -0.084 0.17 -9999 0 -0.52 22 22
TMPRSS2 -0.66 0.49 -9999 0 -1 138 138
CCND1 0.024 0.047 -9999 0 -0.66 1 1
PIAS1 0.027 0.01 -9999 0 -10000 0 0
mol:T-DHT -0.043 0.035 -9999 0 -0.069 134 134
CDC2L1 0 0.001 -9999 0 -10000 0 0
PIAS4 0.027 0.014 -9999 0 -10000 0 0
T-DHT/AR/CDK6 -0.054 0.1 -9999 0 -0.44 9 9
CMTM2 0.018 0.026 -9999 0 -10000 0 0
SNURF -0.02 0.16 -9999 0 -0.63 13 13
ZMIZ1 -0.037 0.051 -9999 0 -10000 0 0
CCND3 0.027 0.007 -9999 0 -10000 0 0
TGIF1 0.026 0.009 -9999 0 -10000 0 0
FKBP4 0.026 0.01 -9999 0 -10000 0 0
ErbB4 signaling events

Figure S37.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S37.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ErbB4/ErbB4/HBEGF/HBEGF -0.1 0.1 -10000 0 -0.5 2 2
epithelial cell differentiation -0.18 0.18 -10000 0 -0.39 68 68
ITCH 0.056 0.024 -10000 0 -10000 0 0
WWP1 -0.089 0.08 -10000 0 -10000 0 0
FYN 0.027 0.005 -10000 0 -10000 0 0
EGFR 0.022 0.011 -10000 0 -10000 0 0
PRL -0.012 0.016 -10000 0 -10000 0 0
neuron projection morphogenesis -0.055 0.089 0.33 1 -0.41 2 3
PTPRZ1 0 0.068 -10000 0 -0.66 2 2
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/GRB2/SHC -0.06 0.094 -10000 0 -0.44 2 2
ErbB4 CYT2/ErbB4 CYT2/neuregulin 1 beta/neuregulin 1 beta -0.086 0.088 -10000 0 -0.41 5 5
ADAM17 0.057 0.022 -10000 0 -10000 0 0
ErbB4/ErbB4 -0.12 0.1 -10000 0 -0.31 5 5
ErbB4/ErbB4/neuregulin 3/neuregulin 3 -0.1 0.11 -10000 0 -0.46 3 3
NCOR1 0.026 0.008 -10000 0 -10000 0 0
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/Fyn -0.076 0.089 -10000 0 -0.42 4 4
GRIN2B -0.079 0.08 -10000 0 -0.4 4 4
ErbB4/ErbB2/betacellulin -0.071 0.098 -10000 0 -0.48 4 4
STAT1 0.027 0.01 -10000 0 -10000 0 0
HBEGF 0.021 0.067 -10000 0 -0.66 2 2
PRLR -0.29 0.34 -10000 0 -0.65 97 97
E4ICDs/ETO2 -0.095 0.098 -10000 0 -10000 0 0
axon guidance -0.057 0.063 -10000 0 -10000 0 0
NEDD4 0.056 0.023 -10000 0 -10000 0 0
Prolactin receptor/Prolactin receptor/Prolactin -0.21 0.26 -10000 0 -0.5 97 97
CBFA2T3 0.025 0.01 -10000 0 -10000 0 0
ErbB4/ErbB2/HBEGF -0.065 0.085 -10000 0 -0.54 1 1
MAPK3 -0.064 0.08 -10000 0 -0.42 2 2
STAT1 (dimer) -0.099 0.097 -10000 0 -10000 0 0
MAPK1 -0.062 0.08 -10000 0 -0.42 2 2
JAK2 0.026 0.007 -10000 0 -10000 0 0
ErbB4/ErbB2/neuregulin 1 beta -0.072 0.091 -10000 0 -0.42 4 4
NRG1 0.019 0.074 -10000 0 -0.5 4 4
NRG3 0.016 0.069 -10000 0 -0.66 2 2
NRG2 0.019 0.071 -10000 0 -0.55 3 3
NRG4 0.021 0.03 -10000 0 -0.34 1 1
heart development -0.057 0.063 -10000 0 -10000 0 0
neural crest cell migration -0.071 0.09 -10000 0 -0.42 4 4
ERBB2 0.029 0.015 -10000 0 -10000 0 0
WWOX/E4ICDs -0.096 0.097 -10000 0 -0.27 5 5
SHC1 0.027 0.005 -10000 0 -10000 0 0
ErbB4/EGFR/neuregulin 4 -0.069 0.099 -10000 0 -0.41 1 1
apoptosis 0.085 0.092 0.45 3 -10000 0 3
ErbB4/ErbB4/neuregulin 2 beta/neuregulin 2 beta -0.11 0.1 -10000 0 -0.39 3 3
ErbB4/ErbB2/epiregulin -0.074 0.082 -10000 0 -10000 0 0
ErbB4/ErbB4/betacellulin/betacellulin -0.11 0.12 -10000 0 -0.55 5 5
ErbB4/ErbB4/HBEGF/HBEGF/Prolactin receptor/Prolactin receptor/Prolactin/JAK2 -0.25 0.21 -10000 0 -0.45 97 97
MDM2 -0.099 0.096 0.25 3 -10000 0 3
ErbB4 JM-B/ErbB4 JM-B/neuregulin 1 beta/neuregulin 1 beta -0.055 0.079 -10000 0 -0.41 4 4
STAT5A -0.048 0.07 -10000 0 -10000 0 0
ErbB4/EGFR/neuregulin 1 beta -0.06 0.09 -10000 0 -0.42 4 4
DLG4 0.026 0.008 -10000 0 -10000 0 0
GRB2/SHC 0.037 0.013 -10000 0 -10000 0 0
E4ICDs/TAB2/NCoR1 -0.09 0.088 -10000 0 -10000 0 0
STAT5A (dimer) -0.19 0.19 -10000 0 -0.42 63 63
MAP3K7IP2 0 0 -10000 0 -10000 0 0
STAT5B (dimer) -0.049 0.066 -10000 0 -10000 0 0
LRIG1 0.027 0.006 -10000 0 -10000 0 0
EREG -0.024 0.048 -10000 0 -10000 0 0
BTC 0.009 0.11 -10000 0 -0.6 6 6
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta -0.057 0.063 -10000 0 -10000 0 0
ERBB4 -0.12 0.1 -10000 0 -0.31 5 5
STAT5B 0.026 0.008 -10000 0 -10000 0 0
YAP1 -0.028 0.08 -10000 0 -0.5 5 5
GRB2 0.026 0.008 -10000 0 -10000 0 0
ErbB4/ErbB2/neuregulin 4 -0.066 0.08 -10000 0 -0.35 1 1
glial cell differentiation 0.089 0.087 -10000 0 -10000 0 0
WWOX 0.026 0.008 -10000 0 -10000 0 0
cell proliferation -0.057 0.12 0.7 1 -0.43 6 7
p75(NTR)-mediated signaling

Figure S38.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S38.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Sortilin/TRAF6 0.039 0.01 -10000 0 -10000 0 0
Necdin/E2F1 -0.015 0.12 -10000 0 -0.45 13 13
proNGF (dimer)/p75(NTR)/Sortilin/NADE/14-3-3 E 0.056 0.091 -10000 0 -0.43 6 6
NGF (dimer)/p75(NTR)/BEX1 -0.002 0.15 -10000 0 -0.42 23 23
NT-4/5 (dimer)/p75(NTR) 0.015 0.077 -10000 0 -0.5 4 4
IKBKB 0.027 0.005 -10000 0 -10000 0 0
AKT1 0.012 0.094 0.35 2 -0.42 6 8
IKBKG 0.028 0.002 -10000 0 -10000 0 0
BDNF 0.014 0.035 -10000 0 -10000 0 0
MGDIs/NGR/p75(NTR)/LINGO1 0.033 0.077 -10000 0 -0.39 6 6
FURIN 0.027 0.004 -10000 0 -10000 0 0
proBDNF (dimer)/p75(NTR)/Sortilin 0.03 0.073 -10000 0 -0.44 4 4
LINGO1 0.021 0.066 -10000 0 -0.66 2 2
Sortilin/TRAF6/NRIF 0.033 0.03 -10000 0 -0.35 1 1
proBDNF (dimer) 0.014 0.035 -10000 0 -10000 0 0
NTRK1 -0.098 0.26 -10000 0 -0.65 37 37
RTN4R 0.024 0.016 -10000 0 -10000 0 0
neuron apoptosis 0.006 0.11 0.29 3 -0.48 6 9
IRAK1 0.028 0.002 -10000 0 -10000 0 0
SHC1 -0.001 0.088 -10000 0 -0.48 6 6
ARHGDIA 0.026 0.008 -10000 0 -10000 0 0
RhoA/GTP 0.02 0.005 -10000 0 -10000 0 0
Gamma Secretase 0.073 0.04 -10000 0 -0.38 1 1
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-H1 0.046 0.095 -10000 0 -0.45 6 6
MAGEH1 0.027 0.008 -10000 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/Necdin 0.022 0.15 -10000 0 -0.48 15 15
Mammalian IAPs/DIABLO 0.066 0.019 -10000 0 -10000 0 0
proNGF (dimer) 0.009 0.1 -10000 0 -0.66 5 5
MAGED1 0.028 0.003 -10000 0 -10000 0 0
APP 0.026 0.008 -10000 0 -10000 0 0
NT-4/5 (dimer) -0.004 0.034 -10000 0 -10000 0 0
ZNF274 0.028 0.003 -10000 0 -10000 0 0
RhoA/GDP/RHOGDI 0.021 0.081 -10000 0 -0.43 6 6
NGF 0.009 0.1 -10000 0 -0.66 5 5
cell cycle arrest -0.008 0.094 0.21 9 -0.4 6 15
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK 0.015 0.068 -10000 0 -0.35 6 6
NT-4/5 (dimer)/p75(NTR)/TRAF6 0.029 0.072 -10000 0 -0.44 4 4
NCSTN 0.027 0.006 -10000 0 -10000 0 0
mol:GTP 0.032 0.097 -10000 0 -0.42 8 8
PSENEN 0.028 0.003 -10000 0 -10000 0 0
mol:ceramide 0.009 0.092 -10000 0 -0.44 6 6
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs 0.009 0.071 -10000 0 -0.44 3 3
p75(NTR)/beta APP 0.026 0.073 -10000 0 -0.49 4 4
BEX1 -0.022 0.18 -10000 0 -0.66 15 15
mol:GDP -0.022 0.086 -10000 0 -0.42 8 8
NGF (dimer) -0.22 0.24 -10000 0 -0.42 121 121
MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI 0.049 0.074 -10000 0 -0.39 5 5
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
RAC1/GTP 0.021 0.083 -10000 0 -0.43 6 6
MYD88 0.027 0.006 -10000 0 -10000 0 0
CHUK 0.028 0.003 -10000 0 -10000 0 0
NGF (dimer)/p75(NTR)/PKA 0.032 0.098 -10000 0 -0.42 8 8
RHOB 0.027 0.005 -10000 0 -10000 0 0
RHOA 0.027 0.006 -10000 0 -10000 0 0
MAGE-G1/E2F1 0.013 0.04 -10000 0 -10000 0 0
NT3 (dimer) -0.082 0.25 -10000 0 -0.66 33 33
TP53 -0.018 0.056 -10000 0 -0.37 4 4
PRDM4 0.006 0.089 -10000 0 -0.45 6 6
BDNF (dimer) -0.22 0.22 -10000 0 -0.41 119 119
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
SORT1 0.027 0.006 -10000 0 -10000 0 0
activation of caspase activity 0.05 0.089 -10000 0 -0.42 6 6
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 0.046 0.095 -10000 0 -0.45 6 6
RHOC 0.027 0.006 -10000 0 -10000 0 0
XIAP 0.028 0 -10000 0 -10000 0 0
MAPK10 0.017 0.098 0.25 3 -0.46 4 7
DIABLO 0.027 0.006 -10000 0 -10000 0 0
SMPD2 0.009 0.093 -10000 0 -0.44 6 6
APH1B 0.024 0.047 -10000 0 -0.66 1 1
APH1A 0.027 0.005 -10000 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin 0.032 0.098 -10000 0 -0.42 8 8
PSEN1 0.026 0.007 -10000 0 -10000 0 0
APAF-1/Pro-Caspase 9 0.036 0.014 -10000 0 -10000 0 0
NT3 (dimer)/p75(NTR) -0.055 0.2 -10000 0 -0.5 36 36
MAPK8 0.013 0.1 0.25 2 -0.42 6 8
MAPK9 0.016 0.097 0.25 3 -0.42 6 9
APAF1 0.027 0.006 -10000 0 -10000 0 0
NTF3 -0.082 0.25 -10000 0 -0.66 33 33
NTF4 -0.004 0.034 -10000 0 -10000 0 0
NDN -0.013 0.16 -10000 0 -0.63 13 13
RAC1/GDP 0.017 0.008 -10000 0 -10000 0 0
RhoA-B-C/GDP 0.048 0.086 -10000 0 -0.4 6 6
p75 CTF/Sortilin/TRAF6/NRIF 0.065 0.022 -10000 0 -10000 0 0
RhoA-B-C/GTP 0.031 0.097 -10000 0 -0.42 8 8
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.061 0.069 -10000 0 -0.39 4 4
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 0.051 0.068 -10000 0 -0.41 4 4
PRKACB 0.027 0.007 -10000 0 -10000 0 0
proBDNF (dimer)/p75 ECD 0.027 0.032 -10000 0 -10000 0 0
ChemicalAbstracts:86-01-1 0 0 -10000 0 -10000 0 0
BIRC3 0.021 0.025 -10000 0 -10000 0 0
BIRC2 0.027 0.005 -10000 0 -10000 0 0
neuron projection morphogenesis -0.018 0.12 0.27 2 -0.47 9 11
BAD 0.017 0.1 0.27 4 -0.47 4 8
RIPK2 0.027 0.004 -10000 0 -10000 0 0
NGFR 0.013 0.093 -10000 0 -0.66 4 4
CYCS -0.012 0.086 0.36 1 -0.43 6 7
ADAM17 0.027 0.005 -10000 0 -10000 0 0
NGF (dimer)/p75(NTR)/TRAF6/RIP2 0.045 0.095 -10000 0 -0.39 8 8
BCL2L11 0.018 0.1 0.29 5 -0.47 4 9
BDNF (dimer)/p75(NTR) 0.017 0.079 -10000 0 -0.51 4 4
PI3K 0.046 0.092 -10000 0 -0.45 6 6
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-G1 0.046 0.095 -10000 0 -0.45 6 6
NDNL2 0.027 0.005 -10000 0 -10000 0 0
YWHAE 0.026 0.008 -10000 0 -10000 0 0
PRKCI 0.027 0.005 -10000 0 -10000 0 0
NGF (dimer)/p75(NTR) 0.016 0.11 -10000 0 -0.49 8 8
ChemicalAbstracts:146-91-8 0 0 -10000 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/NRAGE 0.046 0.095 -10000 0 -0.45 6 6
TRAF6 0.028 0.004 -10000 0 -10000 0 0
RAC1 0.022 0.011 -10000 0 -10000 0 0
PRKCZ 0.025 0.008 -10000 0 -10000 0 0
PLG -0.37 0.32 -10000 0 -0.65 119 119
oligodendrocyte cell fate commitment 0 0 -10000 0 -10000 0 0
CASP6 -0.001 0.084 -10000 0 -0.45 6 6
SQSTM1 0.025 0.015 -10000 0 -10000 0 0
NGFRAP1 0.028 0 -10000 0 -10000 0 0
CASP3 0.017 0.1 0.27 5 -0.45 4 9
E2F1 -0.003 0.045 -10000 0 -10000 0 0
CASP9 0.026 0.008 -10000 0 -10000 0 0
IKK complex -0.021 0.17 -10000 0 -0.48 9 9
NGF (dimer)/TRKA -0.066 0.21 -10000 0 -0.49 41 41
MMP7 -0.009 0.1 -10000 0 -0.66 4 4
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.055 0.094 -10000 0 -0.43 6 6
MMP3 -0.011 0.026 -10000 0 -10000 0 0
APAF-1/Caspase 9 -0.026 0.059 -10000 0 -0.57 1 1
Calcium signaling in the CD4+ TCR pathway

Figure S39.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S39.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC1 0.008 0.022 -10000 0 -10000 0 0
NFATC2 -0.018 0.11 -10000 0 -0.43 13 13
NFATC3 0.01 0.02 -10000 0 -10000 0 0
CD40LG -0.054 0.18 0.35 2 -0.53 12 14
PTGS2 -0.098 0.26 0.35 2 -0.66 31 33
JUNB 0.028 0.003 -10000 0 -10000 0 0
CaM/Ca2+/Calcineurin A alpha-beta B1 0.015 0.018 -10000 0 -10000 0 0
CaM/Ca2+ 0.015 0.018 -10000 0 -10000 0 0
CALM1 0.023 0.016 -10000 0 -10000 0 0
JUN 0.023 0.016 -10000 0 -10000 0 0
mol:Ca2+ -0.001 0.006 -10000 0 -10000 0 0
Calcineurin A alpha-beta B1/FKBP12/FK506 0.018 0.007 -10000 0 -10000 0 0
FOSL1 0.026 0.014 -10000 0 -10000 0 0
CREM 0.027 0.005 -10000 0 -10000 0 0
Jun/NFAT1-c-4/p21SNFT 0.01 0.12 -10000 0 -0.37 11 11
FOS -0.075 0.24 -10000 0 -0.61 33 33
IFNG -0.054 0.17 0.35 2 -0.52 12 14
AP-1/NFAT1-c-4 -0.039 0.21 -10000 0 -0.62 12 12
FASLG -0.058 0.17 0.35 2 -0.53 12 14
NFAT1-c-4/ICER1 -0.001 0.1 -10000 0 -0.37 12 12
IL2RA -0.059 0.17 0.35 2 -0.53 12 14
FKBP12/FK506 0.02 0.005 -10000 0 -10000 0 0
CSF2 -0.056 0.18 0.36 1 -0.53 12 13
JunB/Fra1/NFAT1-c-4 0.011 0.1 -10000 0 -0.36 12 12
IL4 -0.057 0.18 0.35 2 -0.53 12 14
IL2 -0.026 0.18 -10000 0 -0.84 10 10
IL3 -0.01 0.14 -10000 0 -0.7 7 7
FKBP1A 0.027 0.006 -10000 0 -10000 0 0
BATF3 0.026 0.009 -10000 0 -10000 0 0
mol:FK506 0 0 -10000 0 -10000 0 0
POU2F1 0.027 0.006 -10000 0 -10000 0 0
IL6-mediated signaling events

Figure S40.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S40.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.007 0.15 0.5 1 -10000 0 1
CRP -0.014 0.15 0.57 1 -0.5 2 3
cell cycle arrest -0.018 0.16 0.41 1 -0.56 2 3
TIMP1 -0.009 0.15 -10000 0 -10000 0 0
IL6ST -0.066 0.24 -10000 0 -0.66 29 29
Rac1/GDP -0.044 0.14 -10000 0 -0.51 7 7
AP1 -0.026 0.15 -10000 0 -0.48 5 5
GAB2 0.028 0.004 -10000 0 -10000 0 0
TNFSF11 -0.016 0.15 -10000 0 -10000 0 0
HSP90B1 0.033 0.039 -10000 0 -10000 0 0
GAB1 0.027 0.007 -10000 0 -10000 0 0
MAPK14 -0.029 0.14 -10000 0 -0.51 7 7
AKT1 0.03 0.024 -10000 0 -10000 0 0
FOXO1 0.033 0.03 -10000 0 -10000 0 0
MAP2K6 -0.043 0.13 -10000 0 -0.39 15 15
mol:GTP 0 0.002 -10000 0 -10000 0 0
MAP2K4 -0.037 0.13 0.34 1 -0.49 6 7
MITF -0.051 0.14 -10000 0 -0.4 18 18
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
TYK2 0.028 0.003 -10000 0 -10000 0 0
A2M 0.008 0.15 -10000 0 -1.3 3 3
CEBPB 0.019 0.025 -10000 0 -10000 0 0
GRB2/SOS1/GAB family/SHP2 0.007 0.087 -10000 0 -0.45 2 2
STAT3 -0.021 0.16 0.42 1 -0.6 2 3
STAT1 0.013 0.019 -10000 0 -10000 0 0
CEBPD -0.011 0.15 0.5 1 -0.5 2 3
PIK3CA 0.028 0.005 -10000 0 -10000 0 0
PI3K 0.041 0.01 -10000 0 -10000 0 0
JUN 0.026 0.007 -10000 0 -10000 0 0
PIAS3/MITF -0.028 0.15 -10000 0 -0.47 10 10
MAPK11 -0.027 0.14 -10000 0 -0.54 6 6
STAT3 (dimer)/FOXO1 -0.022 0.13 -10000 0 -0.47 2 2
GRB2/SOS1/GAB family -0.004 0.15 -10000 0 -0.53 5 5
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/HCK -0.045 0.15 -10000 0 -0.34 35 35
GRB2 0.026 0.008 -10000 0 -10000 0 0
JAK2 0.026 0.007 -10000 0 -10000 0 0
LBP -0.21 0.43 0.42 2 -0.9 57 59
PIK3R1 0.028 0.004 -10000 0 -10000 0 0
JAK1 0.027 0.01 -10000 0 -10000 0 0
MYC -0.011 0.15 0.5 1 -10000 0 1
FGG -0.017 0.15 -10000 0 -10000 0 0
macrophage differentiation -0.018 0.16 0.41 1 -0.56 2 3
IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 -0.025 0.17 -10000 0 -0.39 33 33
JUNB -0.013 0.14 -10000 0 -0.48 2 2
FOS -0.072 0.23 -10000 0 -0.6 33 33
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 -0.048 0.15 -10000 0 -0.34 32 32
STAT1/PIAS1 -0.025 0.15 -10000 0 -0.4 13 13
GRB2/SOS1/GAB family/SHP2/PI3K 0.033 0.025 -10000 0 -10000 0 0
STAT3 (dimer) -0.02 0.16 0.41 1 -0.58 2 3
PRKCD -0.002 0.16 0.33 7 -0.45 5 12
IL6R 0.028 0.008 -10000 0 -10000 0 0
SOCS3 -0.02 0.16 -10000 0 -0.69 5 5
gp130 (dimer)/JAK1/JAK1/LMO4 -0.012 0.17 -10000 0 -0.43 29 29
Rac1/GTP -0.042 0.14 -10000 0 -0.5 7 7
HCK 0.012 0.056 -10000 0 -0.65 1 1
MAPKKK cascade 0.02 0.082 -10000 0 -0.5 2 2
bone resorption -0.013 0.14 -10000 0 -0.49 1 1
IRF1 -0.01 0.15 0.57 1 -0.51 1 2
mol:GDP -0.055 0.14 -10000 0 -0.42 16 16
SOS1 0.027 0.005 -10000 0 -10000 0 0
VAV1 -0.057 0.14 -10000 0 -0.42 16 16
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 -0.041 0.16 -10000 0 -0.51 11 11
PTPN11 0.013 0.019 -10000 0 -10000 0 0
IL6/IL6RA -0.011 0.14 -10000 0 -0.49 16 16
gp130 (dimer)/TYK2/TYK2/LMO4 -0.013 0.17 -10000 0 -0.43 29 29
gp130 (dimer)/JAK2/JAK2/LMO4 -0.015 0.17 -10000 0 -0.43 29 29
IL6 -0.033 0.18 -10000 0 -0.66 16 16
PIAS3 0.027 0.006 -10000 0 -10000 0 0
PTPRE 0.024 0.011 -10000 0 -10000 0 0
PIAS1 0.028 0.004 -10000 0 -10000 0 0
RAC1 0.023 0.011 -10000 0 -10000 0 0
IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 -0.048 0.14 -10000 0 -0.33 36 36
LMO4 0.027 0.012 -10000 0 -10000 0 0
STAT3 (dimer)/PIAS3 -0.017 0.16 -10000 0 -0.63 2 2
MCL1 0.035 0.031 -10000 0 -10000 0 0
S1P3 pathway

Figure S41.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S41.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB -0.002 0.14 -9999 0 -0.66 9 9
mol:S1P 0.001 0 -9999 0 -10000 0 0
S1P1/S1P/Gi 0.003 0.07 -9999 0 -0.28 11 11
GNAO1 -0.01 0.15 -9999 0 -0.66 11 11
S1P/S1P3/G12/G13 0.007 0.11 -9999 0 -0.39 12 12
AKT1 -0.037 0.18 -9999 0 -0.58 17 17
AKT3 -0.007 0.14 -9999 0 -0.6 5 5
mol:GTP 0 0 -9999 0 -10000 0 0
PDGFB-D/PDGFRB -0.002 0.14 -9999 0 -0.66 9 9
GNAI2 0.028 0.007 -9999 0 -10000 0 0
GNAI3 0.028 0.006 -9999 0 -10000 0 0
GNAI1 0.02 0.048 -9999 0 -0.66 1 1
mol:GDP 0 0 -9999 0 -10000 0 0
S1PR3 -0.036 0.2 -9999 0 -0.64 20 20
S1PR2 0.028 0.003 -9999 0 -10000 0 0
EDG1 0 0 -9999 0 -10000 0 0
mol:Ca2+ -0.019 0.16 -9999 0 -0.4 23 23
MAPK3 -0.022 0.14 -9999 0 -0.52 10 10
MAPK1 -0.015 0.14 -9999 0 -0.54 10 10
JAK2 -0.023 0.16 -9999 0 -0.56 11 11
CXCR4 -0.028 0.15 -9999 0 -0.52 11 11
FLT1 0.022 0.067 -9999 0 -0.66 2 2
RhoA/GDP 0.02 0.005 -9999 0 -10000 0 0
Rac1/GDP 0.017 0.008 -9999 0 -10000 0 0
SRC -0.021 0.15 -9999 0 -0.54 10 10
S1P/S1P3/Gi -0.019 0.16 -9999 0 -0.4 23 23
RAC1 0.022 0.011 -9999 0 -10000 0 0
RhoA/GTP -0.014 0.15 -9999 0 -0.49 11 11
VEGFA 0.028 0.01 -9999 0 -10000 0 0
S1P/S1P2/Gi 0.013 0.089 -9999 0 -0.31 10 10
VEGFR1 homodimer/VEGFA homodimer 0.038 0.054 -9999 0 -0.5 2 2
RHOA 0.027 0.006 -9999 0 -10000 0 0
S1P/S1P3/Gq -0.078 0.19 -9999 0 -0.36 56 56
GNAQ 0.026 0.007 -9999 0 -10000 0 0
GNAZ 0.026 0.009 -9999 0 -10000 0 0
G12/G13 0.031 0.018 -9999 0 -10000 0 0
GNA14 -0.11 0.27 -9999 0 -0.64 44 44
GNA15 0.022 0.023 -9999 0 -10000 0 0
GNA12 0.023 0.011 -9999 0 -10000 0 0
GNA13 0.026 0.008 -9999 0 -10000 0 0
GNA11 0.012 0.1 -9999 0 -0.66 5 5
Rac1/GTP -0.024 0.14 -9999 0 -0.49 11 11
E-cadherin signaling in keratinocytes

Figure S42.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S42.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
keratinocyte differentiation 0.009 0.055 -10000 0 -10000 0 0
adherens junction organization -0.002 0.095 0.25 3 -0.28 16 19
mol:GTP 0 0 -10000 0 -10000 0 0
Rac1/GDP 0.013 0.056 -10000 0 -10000 0 0
FMN1 -0.014 0.1 -10000 0 -0.3 20 20
mol:IP3 0.008 0.054 -10000 0 -10000 0 0
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin 0.001 0.09 -10000 0 -0.29 16 16
CTNNB1 0.027 0.008 -10000 0 -10000 0 0
AKT1 0.014 0.068 0.28 2 -10000 0 2
E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin -0.032 0.14 -10000 0 -0.49 16 16
CTNND1 0.03 0.007 -10000 0 -10000 0 0
mol:PI-4-5-P2 -0.001 0.085 -10000 0 -0.27 16 16
VASP -0.003 0.086 -10000 0 -10000 0 0
ZYX -0.007 0.082 -10000 0 -0.28 15 15
JUB -0.002 0.085 -10000 0 -0.28 16 16
EGFR(dimer) 0.009 0.089 -10000 0 -10000 0 0
E-cadherin/beta catenin-gamma catenin 0.014 0.12 -10000 0 -0.41 16 16
mol:PI-3-4-5-P3 0.03 0.075 0.25 1 -10000 0 1
PIK3CA 0.028 0.006 -10000 0 -10000 0 0
PI3K 0.031 0.077 0.26 1 -10000 0 1
FYN -0.18 0.15 -10000 0 -0.38 17 17
mol:Ca2+ 0.008 0.053 -10000 0 -10000 0 0
JUP 0.026 0.009 -10000 0 -10000 0 0
PIK3R1 0.029 0.007 -10000 0 -10000 0 0
mol:DAG 0.008 0.054 -10000 0 -10000 0 0
CDH1 -0.026 0.18 -10000 0 -0.66 16 16
RhoA/GDP 0.04 0.078 -10000 0 -10000 0 0
establishment of polarity of embryonic epithelium -0.001 0.085 -10000 0 -10000 0 0
SRC 0.026 0.009 -10000 0 -10000 0 0
RAC1 0.022 0.011 -10000 0 -10000 0 0
RHOA 0.027 0.006 -10000 0 -10000 0 0
EGFR 0.022 0.011 -10000 0 -10000 0 0
CASR -0.21 0.17 -10000 0 -0.34 118 118
RhoA/GTP 0.021 0.054 -10000 0 -10000 0 0
AKT2 0.015 0.071 0.28 2 -10000 0 2
actin cable formation -0.017 0.1 -10000 0 -0.33 6 6
apoptosis -0.024 0.097 -10000 0 -0.38 8 8
CTNNA1 0.029 0.008 -10000 0 -10000 0 0
mol:GDP 0 0.05 -10000 0 -10000 0 0
PIP5K1A -0.003 0.085 -10000 0 -0.28 16 16
PLCG1 0.008 0.054 -10000 0 -10000 0 0
Rac1/GTP 0.017 0.087 -10000 0 -10000 0 0
homophilic cell adhesion 0.001 0.006 -10000 0 -10000 0 0
Regulation of nuclear SMAD2/3 signaling

Figure S43.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S43.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EP300 0.021 0.02 -10000 0 -10000 0 0
HSPA8 0.025 0.046 -10000 0 -0.64 1 1
SMAD3/SMAD4/ER alpha 0.025 0.11 -10000 0 -0.44 9 9
AKT1 0.028 0.008 -10000 0 -10000 0 0
GSC -0.006 0.097 -10000 0 -0.41 1 1
NKX2-5 0.015 0.021 -10000 0 -10000 0 0
muscle cell differentiation -0.034 0.072 -10000 0 -10000 0 0
SMAD2-3/SMAD4/SP1 0.088 0.043 -10000 0 -10000 0 0
SMAD4 0.028 0.029 -10000 0 -10000 0 0
CBFB 0.026 0.007 -10000 0 -10000 0 0
SAP18 0.027 0.006 -10000 0 -10000 0 0
Cbp/p300/MSG1 0.041 0.031 -10000 0 -10000 0 0
SMAD3/SMAD4/VDR 0.064 0.063 -10000 0 -0.34 1 1
MYC 0.025 0.011 -10000 0 -10000 0 0
CDKN2B -0.009 0.13 -10000 0 -0.53 6 6
AP1 -0.002 0.13 -10000 0 -0.34 22 22
SMAD2/SMAD2/SMAD4/SnoN/SIN3/HDAC complex/NCoR1 0.015 0.1 -10000 0 -0.43 7 7
SMAD2-3/SMAD4/FOXO1-3a-4/FOXG1 0.016 0.044 -10000 0 -10000 0 0
SP3 0.029 0.004 -10000 0 -10000 0 0
CREB1 0.027 0.004 -10000 0 -10000 0 0
FOXH1 0.025 0.022 -10000 0 -10000 0 0
SMAD3/SMAD4/GR 0.057 0.044 -10000 0 -10000 0 0
GATA3 -0.47 0.3 -10000 0 -0.64 155 155
SKI/SIN3/HDAC complex/NCoR1 0.021 0.072 -10000 0 -0.42 4 4
MEF2C/TIF2 0.001 0.12 -10000 0 -0.37 18 18
endothelial cell migration 0.05 0.29 1.3 11 -10000 0 11
MAX 0.028 0.014 -10000 0 -10000 0 0
RBBP7 0.028 0.003 -10000 0 -10000 0 0
RBBP4 0.026 0.007 -10000 0 -10000 0 0
RUNX2 0.024 0.018 -10000 0 -10000 0 0
RUNX3 0.014 0.033 -10000 0 -10000 0 0
RUNX1 0.018 0.028 -10000 0 -10000 0 0
CTBP1 0.027 0.006 -10000 0 -10000 0 0
NR3C1 0.029 0.013 -10000 0 -10000 0 0
VDR 0.017 0.081 -10000 0 -0.66 3 3
CDKN1A 0.023 0.074 -10000 0 -10000 0 0
KAT2B 0.024 0.012 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1 0.063 0.027 -10000 0 -10000 0 0
DCP1A 0.027 0.006 -10000 0 -10000 0 0
SKI 0.026 0.009 -10000 0 -10000 0 0
SERPINE1 -0.052 0.3 -10000 0 -1.3 11 11
SMAD3/SMAD4/ATF2 0.053 0.042 -10000 0 -10000 0 0
SMAD3/SMAD4/ATF3 0.033 0.11 -10000 0 -0.45 8 8
SAP30 0.026 0.01 -10000 0 -10000 0 0
Cbp/p300/PIAS3 0.041 0.033 -10000 0 -10000 0 0
JUN -0.012 0.12 -10000 0 -0.33 21 21
SMAD3/SMAD4/IRF7 0.054 0.043 -10000 0 -10000 0 0
TFE3 0.027 0.023 -10000 0 -10000 0 0
COL1A2 0.027 0.04 -10000 0 -10000 0 0
mesenchymal cell differentiation -0.051 0.041 -10000 0 -10000 0 0
DLX1 0.014 0.027 -10000 0 -10000 0 0
TCF3 0.028 0.003 -10000 0 -10000 0 0
FOS -0.067 0.23 -10000 0 -0.6 33 33
SMAD3/SMAD4/Max 0.055 0.046 -10000 0 -10000 0 0
Cbp/p300/SNIP1 0.041 0.029 -10000 0 -10000 0 0
ZBTB17 0.024 0.008 -10000 0 -10000 0 0
LAMC1 0.021 0.032 -10000 0 -10000 0 0
TGIF2/HDAC complex/SMAD3/SMAD4 0.054 0.04 -10000 0 -10000 0 0
IRF7 0.028 0.006 -10000 0 -10000 0 0
ESR1 -0.008 0.14 -10000 0 -0.58 12 12
HNF4A -0.061 0.23 -10000 0 -0.66 27 27
MEF2C 0.021 0.041 0.31 2 -10000 0 2
SMAD2-3/SMAD4 0.059 0.044 -10000 0 -10000 0 0
Cbp/p300/Src-1 0.042 0.029 -10000 0 -10000 0 0
IGHV3OR16-13 0.008 0.043 -10000 0 -0.35 3 3
TGIF2/HDAC complex 0.027 0.006 -10000 0 -10000 0 0
CREBBP 0.023 0.015 -10000 0 -10000 0 0
SKIL 0.027 0.005 -10000 0 -10000 0 0
HDAC1 0.026 0.007 -10000 0 -10000 0 0
HDAC2 0.028 0.005 -10000 0 -10000 0 0
SNIP1 0.027 0.008 -10000 0 -10000 0 0
GCN5L2 -0.002 0.008 -10000 0 -10000 0 0
SMAD3/SMAD4/TFE3 0.056 0.051 -10000 0 -10000 0 0
MSG1/HSC70 0.037 0.038 -10000 0 -0.48 1 1
SMAD2 0.03 0.009 -10000 0 -10000 0 0
SMAD3 0.027 0.03 -10000 0 -10000 0 0
SMAD3/E2F4-5/DP1/p107/SMAD4 0.031 0.025 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4 0 0.065 -10000 0 -0.41 3 3
NCOR1 0.026 0.008 -10000 0 -10000 0 0
NCOA2 -0.031 0.19 -10000 0 -0.66 18 18
NCOA1 0.027 0.005 -10000 0 -10000 0 0
MYOD/E2A 0.032 0.013 -10000 0 -10000 0 0
SMAD2-3/SMAD4/SP1/MIZ-1 0.094 0.049 -10000 0 -10000 0 0
IFNB1 0.014 0.028 -10000 0 -10000 0 0
SMAD3/SMAD4/MEF2C 0.054 0.041 -10000 0 -10000 0 0
CITED1 0.025 0.014 -10000 0 -10000 0 0
SMAD2-3/SMAD4/ARC105 0.068 0.047 -10000 0 -10000 0 0
RBL1 0.027 0.006 -10000 0 -10000 0 0
SMAD2-3/SMAD4/FOXO1-3a-4/CEBPB 0.024 0.044 -10000 0 -10000 0 0
RUNX1-3/PEBPB2 0.028 0.041 -10000 0 -10000 0 0
SMAD7 0.017 0.11 -10000 0 -10000 0 0
MYC/MIZ-1 0.034 0.014 -10000 0 -10000 0 0
SMAD3/SMAD4 -0.009 0.1 -10000 0 -0.4 11 11
IL10 -0.28 0.18 -10000 0 -0.39 148 148
PIASy/HDAC complex 0.03 0.009 -10000 0 -10000 0 0
PIAS3 0.024 0.014 -10000 0 -10000 0 0
CDK2 0.024 0.013 -10000 0 -10000 0 0
IL5 -0.28 0.18 -10000 0 -0.39 147 147
CDK4 0.024 0.014 -10000 0 -10000 0 0
PIAS4 0.03 0.009 -10000 0 -10000 0 0
ATF3 -0.001 0.13 -10000 0 -0.62 9 9
SMAD3/SMAD4/SP1 0.065 0.044 -10000 0 -10000 0 0
FOXG1 -0.005 0.026 -10000 0 -10000 0 0
FOXO3 0.014 0.007 -10000 0 -10000 0 0
FOXO1 0.015 0.006 -10000 0 -10000 0 0
FOXO4 0.014 0.007 -10000 0 -10000 0 0
heart looping 0.021 0.04 0.31 2 -10000 0 2
CEBPB 0.026 0.015 -10000 0 -10000 0 0
SMAD3/SMAD4/DLX1 0.049 0.044 -10000 0 -10000 0 0
MYOD1 -0.013 0.018 -10000 0 -10000 0 0
SMAD3/SMAD4/HNF4 -0.009 0.17 -10000 0 -0.45 27 27
SMAD3/SMAD4/GATA3 -0.3 0.22 -10000 0 -0.44 151 151
SnoN/SIN3/HDAC complex/NCoR1 0.027 0.005 -10000 0 -10000 0 0
SMAD3/SMAD4/RUNX1-3/PEBPB2 0.061 0.052 -10000 0 -10000 0 0
SMAD3/SMAD4/SP1-3 0.083 0.042 -10000 0 -10000 0 0
MED15 0.026 0.008 -10000 0 -10000 0 0
SP1 0.033 0.007 -10000 0 -10000 0 0
SIN3B 0.028 0.002 -10000 0 -10000 0 0
SIN3A 0.028 0.004 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1/NKX2-5 0.072 0.032 -10000 0 -10000 0 0
ITGB5 0.032 0.036 -10000 0 -10000 0 0
TGIF/SIN3/HDAC complex/CtBP 0.022 0.061 -10000 0 -0.51 2 2
SMAD3/SMAD4/AR 0.031 0.11 -10000 0 -0.46 9 9
AR -0.002 0.14 -10000 0 -0.66 9 9
negative regulation of cell growth 0.017 0.062 -10000 0 -10000 0 0
SMAD3/SMAD4/MYOD 0.047 0.042 -10000 0 -10000 0 0
E2F5 0.027 0.005 -10000 0 -10000 0 0
E2F4 0.026 0.007 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1/SMIF 0.076 0.04 -10000 0 -10000 0 0
SMAD2-3/SMAD4/FOXO1-3a-4 0.031 0.021 -10000 0 -10000 0 0
TFDP1 0.027 0.006 -10000 0 -10000 0 0
SMAD3/SMAD4/AP1 0.018 0.14 -10000 0 -0.34 22 22
SMAD3/SMAD4/RUNX2 0.052 0.041 -10000 0 -10000 0 0
TGIF2 0.027 0.006 -10000 0 -10000 0 0
TGIF1 0.026 0.008 -10000 0 -10000 0 0
ATF2 0.028 0.004 -10000 0 -10000 0 0
Osteopontin-mediated events

Figure S44.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S44.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IKK alpha homodimer 0.019 0.089 -10000 0 -0.36 10 10
NF kappa B1 p50/RelA/I kappa B alpha 0.047 0.12 0.36 13 -0.39 1 14
alphaV/beta3 Integrin/Osteopontin/Src 0.036 0.058 -10000 0 -0.4 3 3
AP1 -0.001 0.17 -10000 0 -0.59 6 6
ILK 0.015 0.098 -10000 0 -0.38 10 10
bone resorption 0.022 0.11 0.32 3 -0.37 8 11
PTK2B 0.027 0.006 -10000 0 -10000 0 0
PYK2/p130Cas 0.051 0.1 -10000 0 -0.35 10 10
ITGAV 0.03 0.008 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
CD44/Rho Family GTPase/ROCK2 0.029 0.057 -10000 0 -0.5 2 2
alphaV/beta3 Integrin/Osteopontin 0.034 0.1 -10000 0 -0.42 10 10
MAP3K1 0.013 0.099 -10000 0 -0.38 10 10
JUN 0.027 0.007 -10000 0 -10000 0 0
MAPK3 -0.004 0.082 -10000 0 -0.36 10 10
MAPK1 -0.005 0.081 -10000 0 -0.36 10 10
Rac1/GDP 0.017 0.008 -10000 0 -10000 0 0
NFKB1 0.027 0.006 -10000 0 -10000 0 0
MAPK8 0.005 0.11 0.38 2 -0.39 10 12
ITGB3 0.001 0.13 -10000 0 -0.65 8 8
NFKBIA -0.006 0.08 -10000 0 -0.36 10 10
FOS -0.071 0.23 -10000 0 -0.6 33 33
CD44 0.021 0.025 -10000 0 -10000 0 0
CHUK 0.028 0.003 -10000 0 -10000 0 0
PLAU 0.023 0.14 0.47 6 -0.93 1 7
NF kappa B1 p50/RelA 0.046 0.093 -10000 0 -10000 0 0
BCAR1 0.026 0.007 -10000 0 -10000 0 0
RELA 0.028 0.002 -10000 0 -10000 0 0
alphaV beta3 Integrin 0.021 0.1 -10000 0 -0.49 8 8
mol:GDP 0 0 -10000 0 -10000 0 0
SYK 0.013 0.099 -10000 0 -0.38 10 10
VAV3 0.008 0.1 0.38 2 -0.36 10 12
MAP3K14 0.004 0.09 -10000 0 -0.38 10 10
ROCK2 0.021 0.067 -10000 0 -0.66 2 2
SPP1 0.019 0.072 -10000 0 -0.55 3 3
RAC1 0.022 0.011 -10000 0 -10000 0 0
Rac1/GTP 0.013 0.076 0.34 1 -0.33 5 6
MMP2 -0.026 0.13 0.31 1 -0.49 5 6
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)

Figure S45.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S45.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MET/RANBP9 0.026 0.025 -10000 0 -10000 0 0
CRKL 0.02 0.13 0.32 2 -0.42 11 13
mol:PIP3 0.003 0.012 -10000 0 -10000 0 0
AKT1 0.015 0.056 -10000 0 -10000 0 0
PTK2B 0.027 0.006 -10000 0 -10000 0 0
RAPGEF1 0.022 0.13 0.31 3 -0.4 11 14
RANBP10 0.026 0.007 -10000 0 -10000 0 0
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
HGF/MET/SHIP2 0.02 0.096 -10000 0 -0.43 8 8
MAP3K5 0.028 0.13 0.33 6 -0.39 11 17
HGF/MET/CIN85/CBL/ENDOPHILINS 0.035 0.093 -10000 0 -0.4 8 8
AP1 -0.014 0.16 -10000 0 -0.39 28 28
mol:SU11274 0 0 -10000 0 -10000 0 0
SHC1 0.027 0.005 -10000 0 -10000 0 0
apoptosis -0.11 0.34 -10000 0 -0.78 40 40
STAT3 (dimer) 0.004 0.063 -10000 0 -0.37 1 1
GAB1/CRKL/SHP2/PI3K 0.046 0.13 -10000 0 -0.39 11 11
INPP5D 0.024 0.017 -10000 0 -10000 0 0
CBL/CRK 0.045 0.15 0.43 6 -0.41 11 17
PTPN11 0.027 0.006 -10000 0 -10000 0 0
GO:0007205 0 0 -10000 0 -10000 0 0
PLCG1 0.027 0.006 -10000 0 -10000 0 0
PTEN 0.028 0.003 -10000 0 -10000 0 0
ELK1 0.08 0.16 0.34 52 -10000 0 52
mol:SU5416 0 0 -10000 0 -10000 0 0
SHP2/GRB2/SOS1GAB1 0.002 0.051 -10000 0 -0.25 2 2
PAK1 0.013 0.053 -10000 0 -10000 0 0
HGF/MET/RANBP10 0.02 0.093 -10000 0 -0.39 9 9
HRAS -0.009 0.11 -10000 0 -0.47 5 5
DOCK1 0.021 0.13 0.31 3 -0.4 11 14
GAB1 0.016 0.14 0.24 2 -0.45 11 13
CRK 0.027 0.15 0.41 5 -0.43 11 16
mol:PHA665752 0 0 -10000 0 -10000 0 0
mol:GDP -0.011 0.12 -10000 0 -0.52 9 9
JUN 0.026 0.007 -10000 0 -10000 0 0
EntrezGene:200958 0 0 -10000 0 -10000 0 0
HGF/MET -0.002 0.048 -10000 0 -0.23 8 8
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
cell morphogenesis 0.027 0.11 0.44 4 -10000 0 4
GRB2/SHC 0.048 0.072 -10000 0 -0.27 1 1
FOS -0.071 0.23 -10000 0 -0.6 33 33
GLMN 0.003 0.001 -10000 0 -10000 0 0
cell motility 0.08 0.16 0.33 52 -10000 0 52
HGF/MET/MUC20 0.007 0.091 -10000 0 -0.41 9 9
cell migration 0.029 0.06 -10000 0 -0.26 1 1
GRB2 0.026 0.008 -10000 0 -10000 0 0
CBL 0.027 0.005 -10000 0 -10000 0 0
MET/RANBP10 0.027 0.025 -10000 0 -10000 0 0
HGF/MET/Paxillin/FAK1/FAK12/RasGAP 0.008 0.064 -10000 0 -0.3 6 6
MET/MUC20 0.013 0.016 -10000 0 -10000 0 0
RAP1B 0.027 0.14 0.41 7 -0.38 11 18
RAP1A 0.02 0.12 0.3 3 -0.37 11 14
HGF/MET/RANBP9 0.019 0.095 -10000 0 -0.4 9 9
RAF1 0.015 0.12 0.32 1 -0.54 2 3
STAT3 0.004 0.063 -10000 0 -0.37 1 1
cell proliferation 0.022 0.097 -10000 0 -0.4 5 5
RPS6KB1 0.007 0.021 -10000 0 -10000 0 0
MAPK3 0.048 0.14 0.47 5 -10000 0 5
MAPK1 0.11 0.23 0.68 22 -10000 0 22
RANBP9 0.027 0.006 -10000 0 -10000 0 0
MAPK8 0.037 0.16 0.47 7 -0.52 6 13
SRC 0 0.058 -10000 0 -0.35 1 1
PI3K 0.048 0.071 -10000 0 -10000 0 0
MET/Glomulin 0.008 0.031 -10000 0 -10000 0 0
SOS1 0.027 0.004 -10000 0 -10000 0 0
MAP2K1 0.025 0.13 0.38 4 -0.5 2 6
MET 0.017 0.024 -10000 0 -10000 0 0
MAP4K1 0.03 0.14 0.35 6 -0.42 11 17
PTK2 0.027 0.004 -10000 0 -10000 0 0
MAP2K2 0.025 0.13 0.36 5 -0.5 2 7
BAD 0.013 0.053 -10000 0 -10000 0 0
MAP2K4 0.035 0.14 0.39 11 -0.39 6 17
SHP2/GRB2/SOS1/GAB1 0.011 0.1 -10000 0 -0.38 9 9
INPPL1 0.028 0.003 -10000 0 -10000 0 0
PXN 0.027 0.006 -10000 0 -10000 0 0
SH3KBP1 0.028 0.003 -10000 0 -10000 0 0
HGS -0.004 0.042 -10000 0 -0.22 7 7
PLCgamma1/PKC 0.02 0.005 -10000 0 -10000 0 0
HGF -0.007 0.14 -10000 0 -0.66 9 9
RASA1 0.027 0.005 -10000 0 -10000 0 0
NCK1 0.027 0.006 -10000 0 -10000 0 0
PTPRJ 0.028 0.004 -10000 0 -10000 0 0
NCK/PLCgamma1 0.024 0.056 -10000 0 -0.23 7 7
PDPK1 0.017 0.06 -10000 0 -10000 0 0
HGF/MET/SHIP 0.017 0.096 -10000 0 -0.41 9 9
Presenilin action in Notch and Wnt signaling

Figure S46.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S46.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Delta 1/NOTCH/NOTCH(cleaved) 0.003 0.14 -10000 0 -0.5 4 4
HDAC1 0.024 0.007 -10000 0 -10000 0 0
AES 0.027 0.003 -10000 0 -10000 0 0
FBXW11 0.027 0.005 -10000 0 -10000 0 0
DTX1 0.02 0.067 -10000 0 -0.66 2 2
LRP6/FZD1 0.032 0.018 -10000 0 -10000 0 0
TLE1 0.026 0.007 -10000 0 -10000 0 0
AP1 -0.11 0.21 -10000 0 -0.38 68 68
NCSTN 0.027 0.006 -10000 0 -10000 0 0
ADAM10 0.027 0.008 -10000 0 -10000 0 0
Beta Catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 0.028 0.077 -10000 0 -0.61 1 1
NICD/RBPSUH 0.018 0.11 -10000 0 -0.39 3 3
WIF1 0.009 0.025 -10000 0 -10000 0 0
NOTCH1 0.008 0.094 -10000 0 -0.39 10 10
PSENEN 0.028 0.003 -10000 0 -10000 0 0
KREMEN2 0.013 0.03 -10000 0 -10000 0 0
DKK1 0.012 0.029 -10000 0 -10000 0 0
beta catenin/beta TrCP1 0.06 0.11 0.37 3 -10000 0 3
APH1B 0.024 0.047 -10000 0 -0.66 1 1
APH1A 0.027 0.005 -10000 0 -10000 0 0
AXIN1 -0.005 0.056 -10000 0 -10000 0 0
CtBP/CBP/TCF1/TLE1/AES 0.008 0.061 -10000 0 -0.4 4 4
PSEN1 0.026 0.007 -10000 0 -10000 0 0
FOS -0.071 0.23 -10000 0 -0.6 33 33
JUN 0.026 0.007 -10000 0 -10000 0 0
MAP3K7 0.026 0.005 -10000 0 -10000 0 0
CTNNB1 0.052 0.12 0.33 6 -10000 0 6
MAPK3 0.026 0.008 -10000 0 -10000 0 0
DKK2/LRP6/Kremen 2 0.037 0.046 -10000 0 -0.43 1 1
HNF1A 0.013 0.093 -10000 0 -0.66 4 4
CTBP1 0.026 0.006 -10000 0 -10000 0 0
MYC 0.022 0.083 -10000 0 -0.81 2 2
NKD1 -0.15 0.29 -10000 0 -0.66 52 52
FZD1 0.022 0.013 -10000 0 -10000 0 0
NOTCH1 precursor/Deltex homolog 1 0.012 0.12 -10000 0 -0.47 4 4
apoptosis -0.11 0.2 -10000 0 -0.38 68 68
Delta 1/NOTCHprecursor 0 0.13 -10000 0 -0.5 4 4
DLL1 -0.008 0.14 -10000 0 -0.6 11 11
PPARD -0.012 0.18 -10000 0 -0.79 11 11
Gamma Secretase 0.074 0.041 -10000 0 -0.38 1 1
APC -0.012 0.088 -10000 0 -0.57 3 3
DVL1 0.016 0.012 -10000 0 -10000 0 0
CSNK2A1 0.027 0.006 -10000 0 -10000 0 0
MAP3K7IP1 -0.001 0.001 -10000 0 -10000 0 0
DKK1/LRP6/Kremen 2 0.035 0.036 -10000 0 -10000 0 0
LRP6 0.027 0.006 -10000 0 -10000 0 0
CSNK1A1 0.028 0.005 -10000 0 -10000 0 0
NLK 0.011 0.005 -10000 0 -10000 0 0
CCND1 0.012 0.14 -10000 0 -0.97 4 4
WNT1 0.011 0.033 -10000 0 -10000 0 0
Axin1/APC/beta catenin 0.05 0.11 0.36 9 -0.49 2 11
DKK2 0.021 0.049 -10000 0 -0.66 1 1
NOTCH1 precursor/DVL1 0.007 0.13 -10000 0 -0.51 6 6
GSK3B 0.027 0.006 -10000 0 -10000 0 0
FRAT1 0.027 0.003 -10000 0 -10000 0 0
NOTCH/Deltex homolog 1 0.016 0.12 -10000 0 -0.47 4 4
PPP2R5D 0.083 0.15 0.34 47 -0.46 1 48
MAPK1 0.025 0.008 -10000 0 -10000 0 0
WNT1/LRP6/FZD1 0.052 0.029 -10000 0 -10000 0 0
RBPJ 0.027 0.006 -10000 0 -10000 0 0
CREBBP 0.027 0.009 -10000 0 -10000 0 0
Reelin signaling pathway

Figure S47.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S47.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDK5R1/CDK5 0.032 0.018 -10000 0 -10000 0 0
VLDLR 0.026 0.007 -10000 0 -10000 0 0
CRKL 0.026 0.008 -10000 0 -10000 0 0
LRPAP1 0.027 0.005 -10000 0 -10000 0 0
FYN 0.027 0.005 -10000 0 -10000 0 0
ITGA3 0.021 0.021 -10000 0 -10000 0 0
RELN/VLDLR/Fyn -0.004 0.1 -10000 0 -0.43 10 10
MAPK8IP1/MKK7/MAP3K11/JNK1 0.07 0.061 -10000 0 -0.38 3 3
AKT1 -0.014 0.065 -10000 0 -0.29 10 10
MAP2K7 0.028 0.002 -10000 0 -10000 0 0
RAPGEF1 0.026 0.007 -10000 0 -10000 0 0
DAB1 -0.002 0.025 -10000 0 -10000 0 0
RELN/LRP8/DAB1 -0.009 0.096 -10000 0 -0.4 10 10
LRPAP1/LRP8 0.037 0.016 -10000 0 -10000 0 0
RELN/LRP8/DAB1/Fyn 0.02 0.094 -10000 0 -0.38 10 10
DAB1/alpha3/beta1 Integrin 0.017 0.091 -10000 0 -0.36 10 10
long-term memory -0.051 0.18 -10000 0 -0.4 37 37
DAB1/LIS1 0.028 0.095 -10000 0 -0.37 10 10
DAB1/CRLK/C3G 0.018 0.089 -10000 0 -0.36 10 10
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
DAB1/NCK2 0.03 0.097 -10000 0 -0.37 10 10
ARHGEF2 0.027 0.005 -10000 0 -10000 0 0
mol:Src family inhibitors PP1 and PP2 0 0 -10000 0 -10000 0 0
GRIN2A -0.12 0.28 -10000 0 -0.66 44 44
CDK5R1 0.026 0.007 -10000 0 -10000 0 0
RELN -0.035 0.14 -10000 0 -0.66 10 10
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
RELN/LRP8/Fyn -0.006 0.1 -10000 0 -0.43 10 10
GRIN2A/RELN/LRP8/DAB1/Fyn -0.051 0.19 -10000 0 -0.41 38 38
MAPK8 0.016 0.085 -10000 0 -0.58 4 4
RELN/VLDLR/DAB1 -0.009 0.094 -10000 0 -0.4 10 10
ITGB1 0.027 0.005 -10000 0 -10000 0 0
MAP1B 0.006 0.11 -10000 0 -0.38 10 10
RELN/LRP8 -0.006 0.1 -10000 0 -0.43 10 10
GRIN2B/RELN/LRP8/DAB1/Fyn 0.027 0.099 -10000 0 -0.39 10 10
PI3K 0.04 0.009 -10000 0 -10000 0 0
mol:PP2 0 0 -10000 0 -10000 0 0
alpha3/beta1 Integrin 0.034 0.021 -10000 0 -10000 0 0
RAP1A 0.004 0.11 0.32 1 -0.36 1 2
PAFAH1B1 0.026 0.008 -10000 0 -10000 0 0
MAPK8IP1 0.028 0.004 -10000 0 -10000 0 0
CRLK/C3G 0.036 0.014 -10000 0 -10000 0 0
GRIN2B 0.005 0.025 -10000 0 -10000 0 0
NCK2 0.028 0.003 -10000 0 -10000 0 0
neuron differentiation 0.015 0.076 -10000 0 -0.35 3 3
neuron adhesion 0.013 0.13 0.33 10 -10000 0 10
LRP8 0.024 0.015 -10000 0 -10000 0 0
GSK3B -0.005 0.07 -10000 0 -0.36 1 1
RELN/VLDLR/DAB1/Fyn 0.018 0.093 -10000 0 -0.38 10 10
MAP3K11 0.028 0.002 -10000 0 -10000 0 0
RELN/VLDLR/DAB1/P13K -0.007 0.069 -10000 0 -0.3 10 10
CDK5 0.023 0.011 -10000 0 -10000 0 0
MAPT 0.018 0.23 0.69 15 -0.6 10 25
neuron migration 0.014 0.12 0.37 1 -0.38 10 11
RELN/LRP8/DAB1/Fyn/MAPK8IP1/MKK7/MAP3K11/JNK1 0.015 0.076 -10000 0 -0.35 3 3
RELN/VLDLR 0.023 0.099 -10000 0 -0.4 10 10
RXR and RAR heterodimerization with other nuclear receptor

Figure S48.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S48.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 0.022 0.083 -10000 0 -10000 0 0
VDR 0.017 0.081 -10000 0 -0.66 3 3
FAM120B 0.027 0.005 -10000 0 -10000 0 0
RXRs/LXRs/DNA/9cRA 0.035 0.033 -10000 0 -0.26 2 2
RXRs/LXRs/DNA/Oxysterols 0.035 0.053 -10000 0 -0.38 2 2
MED1 0.026 0.008 -10000 0 -10000 0 0
mol:9cRA 0.004 0.005 -10000 0 -10000 0 0
RARs/THRs/DNA/Src-1 0.015 0.062 -10000 0 -0.28 7 7
RXRs/NUR77 -0.12 0.22 -10000 0 -0.39 82 82
RXRs/PPAR 0.024 0.028 -10000 0 -10000 0 0
NCOR2 0.027 0.006 -10000 0 -10000 0 0
VDR/VDR/Vit D3 0.013 0.061 -10000 0 -0.49 3 3
RARs/VDR/DNA/Vit D3 0.052 0.056 -10000 0 -0.38 3 3
RARA 0.026 0.008 -10000 0 -10000 0 0
NCOA1 0.027 0.005 -10000 0 -10000 0 0
VDR/VDR/DNA 0.017 0.081 -10000 0 -0.66 3 3
RARs/RARs/DNA/9cRA 0.046 0.019 -10000 0 -10000 0 0
RARG 0.027 0.009 -10000 0 -10000 0 0
RPS6KB1 0.049 0.14 0.53 17 -10000 0 17
RARs/THRs/DNA/SMRT 0.014 0.065 -10000 0 -0.28 8 8
THRA 0.026 0.008 -10000 0 -10000 0 0
mol:Bile acids 0 0 -10000 0 -10000 0 0
VDR/Vit D3/DNA 0.013 0.061 -10000 0 -0.49 3 3
RXRs/PPAR/9cRA/PGJ2/DNA 0.053 0.029 -10000 0 -10000 0 0
NR1H4 0.013 0.094 -10000 0 -0.66 4 4
RXRs/LXRs/DNA 0.083 0.044 -10000 0 -10000 0 0
NR1H2 0.031 0.009 -10000 0 -10000 0 0
NR1H3 0.031 0.01 -10000 0 -10000 0 0
RXRs/VDR/DNA/Vit D3 0.053 0.059 -10000 0 -0.37 3 3
NR4A1 -0.24 0.33 -10000 0 -0.66 83 83
mol:ATRA 0 0 -10000 0 -10000 0 0
RXRs/FXR/9cRA/MED1 0.014 0.068 -10000 0 -0.34 6 6
RXRG 0.021 0.015 -10000 0 -10000 0 0
RXR alpha/CCPG 0.04 0.014 -10000 0 -10000 0 0
RXRA 0.029 0.011 -10000 0 -10000 0 0
RXRB 0.03 0.011 -10000 0 -10000 0 0
THRB 0.001 0.13 -10000 0 -0.66 8 8
PPARG 0.026 0.009 -10000 0 -10000 0 0
PPARD 0.027 0.007 -10000 0 -10000 0 0
TNF 0.02 0.11 -10000 0 -1.1 2 2
mol:Oxysterols 0.003 0.005 -10000 0 -10000 0 0
cholesterol transport 0.035 0.052 -10000 0 -0.38 2 2
PPARA 0.025 0.008 -10000 0 -10000 0 0
mol:Vit D3 0 0 -10000 0 -10000 0 0
RARB 0.027 0.006 -10000 0 -10000 0 0
RXRs/NUR77/BCL2 -0.11 0.17 -10000 0 -0.32 83 83
SREBF1 0.025 0.047 -10000 0 -10000 0 0
RXRs/RXRs/DNA/9cRA 0.053 0.029 -10000 0 -10000 0 0
ABCA1 0.031 0.044 -10000 0 -10000 0 0
RARs/THRs 0.057 0.091 -10000 0 -0.38 8 8
RXRs/FXR 0.057 0.063 -10000 0 -0.38 3 3
BCL2 0.026 0.008 -10000 0 -10000 0 0
IL27-mediated signaling events

Figure S49.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S49.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 0.028 0.011 -10000 0 -10000 0 0
CD4-positive alpha-beta T cell lineage commitment 0 0 -10000 0 -10000 0 0
cytokine production during immune response 0.006 0.11 -10000 0 -10000 0 0
IL27/IL27R/JAK1 0.1 0.21 -10000 0 -10000 0 0
TBX21 0.056 0.14 0.36 2 -10000 0 2
IL12B 0.01 0.022 -10000 0 -10000 0 0
IL12A 0.005 0.006 -10000 0 -10000 0 0
IL6ST -0.062 0.24 -10000 0 -0.66 29 29
IL27RA/JAK1 0.038 0.033 -10000 0 -10000 0 0
IL27 0.019 0.025 -10000 0 -10000 0 0
TYK2 0.03 0.004 -10000 0 -10000 0 0
T-helper cell lineage commitment -0.002 0.11 -10000 0 -0.49 1 1
T-helper 2 cell differentiation 0.006 0.11 -10000 0 -10000 0 0
T cell proliferation during immune response 0.006 0.11 -10000 0 -10000 0 0
MAPKKK cascade -0.006 0.11 -10000 0 -10000 0 0
STAT3 0.026 0.008 -10000 0 -10000 0 0
STAT2 0.027 0.005 -10000 0 -10000 0 0
STAT1 0.031 0.011 -10000 0 -10000 0 0
IL12RB1 0.022 0.025 -10000 0 -10000 0 0
positive regulation of tyrosine phosphorylation of STAT protein 0 0 -10000 0 -10000 0 0
IL12RB2 0.05 0.16 0.36 4 -0.5 2 6
IL27/IL27R/JAK2/TYK2 -0.006 0.11 -10000 0 -10000 0 0
positive regulation of T cell mediated cytotoxicity -0.006 0.11 -10000 0 -10000 0 0
STAT1 (dimer) 0.24 0.3 0.5 90 -10000 0 90
JAK2 0.027 0.008 -10000 0 -10000 0 0
JAK1 0.031 0.009 -10000 0 -10000 0 0
STAT2 (dimer) 0.012 0.11 -10000 0 -10000 0 0
T cell proliferation -0.03 0.13 -10000 0 -0.51 5 5
IL12/IL12R/TYK2/JAK2 0.031 0.098 -10000 0 -0.7 3 3
IL17A -0.012 0.1 -10000 0 -0.49 1 1
mast cell activation 0.006 0.11 -10000 0 -10000 0 0
IFNG 0.008 0.024 -10000 0 -10000 0 0
T cell differentiation 0.001 0.005 0.013 1 -10000 0 1
STAT3 (dimer) 0.012 0.11 -10000 0 -10000 0 0
STAT5A (dimer) 0.012 0.11 -10000 0 -10000 0 0
STAT4 (dimer) 0.01 0.12 -10000 0 -10000 0 0
STAT4 0.02 0.027 -10000 0 -10000 0 0
T cell activation -0.008 0.005 -10000 0 -10000 0 0
IL27R/JAK2/TYK2 0.009 0.15 -10000 0 -10000 0 0
GATA3 -0.96 0.59 0.69 1 -1.3 155 156
IL18 0.006 0.006 -10000 0 -10000 0 0
positive regulation of mast cell cytokine production 0.012 0.11 -10000 0 -10000 0 0
IL27/EBI3 0.032 0.053 -10000 0 -0.49 1 1
IL27RA 0.014 0.021 -10000 0 -10000 0 0
IL6 -0.035 0.18 -10000 0 -0.66 16 16
STAT5A 0.026 0.008 -10000 0 -10000 0 0
monocyte differentiation 0 0 -10000 0 -10000 0 0
IL2 -0.018 0.016 -10000 0 -10000 0 0
IL1B -0.003 0.069 -10000 0 -0.5 4 4
EBI3 0.016 0.059 -10000 0 -0.65 1 1
TNF -0.001 0.05 -10000 0 -0.5 2 2
TCGA08_rtk_signaling

Figure S50.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S50.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRA -0.2 0.32 -10000 0 -0.64 71 71
HRAS 0.028 0.003 -10000 0 -10000 0 0
EGFR 0.022 0.011 -10000 0 -10000 0 0
AKT 0.036 0.1 0.24 23 -10000 0 23
FOXO3 0.027 0.005 -10000 0 -10000 0 0
AKT1 0.026 0.008 -10000 0 -10000 0 0
FOXO1 0.027 0.006 -10000 0 -10000 0 0
AKT3 0.027 0.006 -10000 0 -10000 0 0
FOXO4 0.028 0.002 -10000 0 -10000 0 0
MET 0.017 0.024 -10000 0 -10000 0 0
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
PIK3CB 0.027 0.006 -10000 0 -10000 0 0
NRAS 0.027 0.006 -10000 0 -10000 0 0
PIK3CG 0.018 0.049 -10000 0 -0.66 1 1
PIK3R3 0.026 0.007 -10000 0 -10000 0 0
PIK3R2 0.028 0.003 -10000 0 -10000 0 0
NF1 0.026 0.007 -10000 0 -10000 0 0
RAS -0.027 0.079 -10000 0 -0.24 5 5
ERBB2 0.026 0.008 -10000 0 -10000 0 0
proliferation/survival/translation -0.033 0.052 0.23 1 -0.21 1 2
PI3K 0.011 0.12 0.25 25 -0.21 7 32
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
KRAS 0.027 0.006 -10000 0 -10000 0 0
FOXO 0.063 0.087 0.24 27 -10000 0 27
AKT2 0.028 0.003 -10000 0 -10000 0 0
PTEN 0.028 0.003 -10000 0 -10000 0 0
E-cadherin signaling in the nascent adherens junction

Figure S51.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S51.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CTTN -0.022 0.15 -10000 0 -0.52 16 16
KLHL20 0.014 0.087 0.2 2 -0.29 2 4
CYFIP2 0.027 0.005 -10000 0 -10000 0 0
Rac1/GDP -0.004 0.11 0.41 2 -0.33 14 16
ENAH -0.023 0.15 -10000 0 -0.52 16 16
AP1M1 0.028 0.002 -10000 0 -10000 0 0
RAP1B 0.027 0.006 -10000 0 -10000 0 0
RAP1A 0.027 0.006 -10000 0 -10000 0 0
CTNNB1 0.027 0.006 -10000 0 -10000 0 0
CDC42/GTP 0.004 0.079 -10000 0 -10000 0 0
ABI1/Sra1/Nap1 -0.017 0.042 -10000 0 -0.2 2 2
E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.027 0.12 -10000 0 -0.4 15 15
RAPGEF1 -0.018 0.13 -10000 0 -0.46 15 15
CTNND1 0.028 0.002 -10000 0 -10000 0 0
regulation of calcium-dependent cell-cell adhesion -0.017 0.16 -10000 0 -0.54 16 16
CRK -0.024 0.14 -10000 0 -0.49 15 15
E-cadherin/gamma catenin/alpha catenin 0.014 0.13 -10000 0 -0.42 16 16
alphaE/beta7 Integrin 0.037 0.013 -10000 0 -10000 0 0
IQGAP1 0.027 0.004 -10000 0 -10000 0 0
NCKAP1 0.028 0.004 -10000 0 -10000 0 0
Rap1/GTP/I-afadin 0.048 0.017 -10000 0 -10000 0 0
DLG1 -0.023 0.15 -10000 0 -0.52 16 16
ChemicalAbstracts:7440-70-2 0 0 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 -0.009 0.055 -10000 0 -0.22 1 1
MLLT4 0.027 0.005 -10000 0 -10000 0 0
ARF6/GTP/NME1/Tiam1 0.043 0.022 -10000 0 -10000 0 0
PI3K -0.008 0.072 -10000 0 -0.28 1 1
ARF6 0.026 0.007 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
E-cadherin/gamma catenin -0.003 0.14 -10000 0 -0.48 16 16
TIAM1 0.026 0.008 -10000 0 -10000 0 0
E-cadherin(dimer)/Ca2+ 0.026 0.12 -10000 0 -0.38 16 16
AKT1 -0.011 0.045 -10000 0 -10000 0 0
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
CDH1 -0.026 0.18 -10000 0 -0.66 16 16
RhoA/GDP 0.008 0.12 0.4 5 -0.33 15 20
actin cytoskeleton organization 0.02 0.074 0.2 7 -0.21 2 9
CDC42/GDP 0.018 0.14 0.48 7 -0.33 15 22
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.004 0.082 -10000 0 -0.29 15 15
ITGB7 0.027 0.005 -10000 0 -10000 0 0
RAC1 0.022 0.011 -10000 0 -10000 0 0
E-cadherin/beta catenin/alpha catenin/p120 catenin 0.029 0.12 -10000 0 -0.4 16 16
E-cadherin/Ca2+/beta catenin/alpha catenin 0.012 0.11 -10000 0 -0.37 16 16
mol:GDP 0 0.15 0.5 7 -0.39 15 22
CDC42/GTP/IQGAP1 0.035 0.011 -10000 0 -10000 0 0
JUP 0.026 0.008 -10000 0 -10000 0 0
p120 catenin/RhoA/GDP 0.008 0.12 0.37 1 -0.34 15 16
RAC1/GTP/IQGAP1 0.029 0.016 -10000 0 -10000 0 0
PIP5K1C/AP1M1 0.041 0.005 -10000 0 -10000 0 0
RHOA 0.027 0.006 -10000 0 -10000 0 0
CDC42 0.026 0.008 -10000 0 -10000 0 0
CTNNA1 0.027 0.005 -10000 0 -10000 0 0
positive regulation of S phase of mitotic cell cycle 0.026 0.074 0.24 11 -0.27 1 12
NME1 0.025 0.012 -10000 0 -10000 0 0
clathrin coat assembly 0 0 -10000 0 -10000 0 0
TJP1 -0.023 0.15 -10000 0 -0.52 16 16
regulation of cell-cell adhesion -0.001 0.068 -10000 0 -0.25 1 1
WASF2 0.01 0.033 -10000 0 -10000 0 0
Rap1/GTP 0.008 0.093 -10000 0 -0.31 3 3
E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.036 0.12 -10000 0 -0.38 15 15
CCND1 0.027 0.079 0.25 10 -0.35 1 11
VAV2 -0.038 0.2 -10000 0 -0.52 27 27
RAP1/GDP 0.013 0.11 0.32 3 -0.32 5 8
adherens junction assembly -0.022 0.14 -10000 0 -0.5 16 16
homophilic cell adhesion 0 0 -10000 0 -10000 0 0
ABI1 0.027 0.005 -10000 0 -10000 0 0
PIP5K1C 0.028 0.003 -10000 0 -10000 0 0
regulation of heterotypic cell-cell adhesion 0.024 0.11 -10000 0 -0.37 15 15
E-cadherin/beta catenin -0.022 0.12 -10000 0 -0.43 16 16
mol:GTP 0 0 -10000 0 -10000 0 0
SRC -0.023 0.15 -10000 0 -0.52 16 16
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
Rac1/GTP -0.025 0.11 -10000 0 -0.4 5 5
E-cadherin/beta catenin/alpha catenin 0.014 0.13 -10000 0 -0.43 16 16
ITGAE 0.026 0.008 -10000 0 -10000 0 0
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.018 0.16 -10000 0 -0.55 16 16
Regulation of Telomerase

Figure S52.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S52.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Telomerase catalytic core complex -0.16 0.13 -9999 0 -0.85 2 2
RAD9A 0.028 0.007 -9999 0 -10000 0 0
AP1 -0.037 0.18 -9999 0 -0.44 33 33
IFNAR2 0.026 0.008 -9999 0 -10000 0 0
AKT1 0.004 0.055 -9999 0 -0.24 9 9
ER alpha/Oestrogen -0.005 0.11 -9999 0 -0.43 12 12
NFX1/SIN3/HDAC complex 0.011 0.085 -9999 0 -0.46 4 4
EGF -0.57 0.22 -9999 0 -0.64 188 188
SMG5 0.027 0.005 -9999 0 -10000 0 0
SMG6 0.026 0.008 -9999 0 -10000 0 0
SP3/HDAC2 0.04 0.01 -9999 0 -10000 0 0
TERT/c-Abl -0.15 0.12 -9999 0 -0.78 2 2
SAP18 0.027 0.006 -9999 0 -10000 0 0
MRN complex 0.052 0.016 -9999 0 -10000 0 0
WT1 -0.38 0.33 -9999 0 -0.65 124 124
WRN 0.027 0.006 -9999 0 -10000 0 0
SP1 0.027 0.007 -9999 0 -10000 0 0
SP3 0.028 0.004 -9999 0 -10000 0 0
TERF2IP 0.026 0.007 -9999 0 -10000 0 0
Telomerase/Nucleolin -0.14 0.12 -9999 0 -0.72 2 2
Mad/Max 0.038 0.013 -9999 0 -10000 0 0
TERT -0.16 0.13 -9999 0 -0.88 2 2
CCND1 -0.15 0.14 -9999 0 -0.88 3 3
MAX 0.026 0.007 -9999 0 -10000 0 0
RBBP7 0.028 0.003 -9999 0 -10000 0 0
RBBP4 0.026 0.007 -9999 0 -10000 0 0
TERF2 0.023 0.009 -9999 0 -10000 0 0
PTGES3 0.027 0.005 -9999 0 -10000 0 0
SIN3A 0.028 0.004 -9999 0 -10000 0 0
Telomerase/911 0.017 0.038 -9999 0 -10000 0 0
CDKN1B 0.016 0.016 -9999 0 -10000 0 0
RAD1 0.028 0.004 -9999 0 -10000 0 0
XRCC5 0.027 0.005 -9999 0 -10000 0 0
XRCC6 0.025 0.008 -9999 0 -10000 0 0
SAP30 0.026 0.01 -9999 0 -10000 0 0
TRF2/PARP2 0.035 0.015 -9999 0 -10000 0 0
UBE3A 0.027 0.005 -9999 0 -10000 0 0
JUN 0.027 0.007 -9999 0 -10000 0 0
E6 0 0.001 -9999 0 -10000 0 0
HPV-16 E6/E6AP 0.02 0.004 -9999 0 -10000 0 0
FOS -0.071 0.23 -9999 0 -0.6 33 33
IFN-gamma/IRF1 0.037 0.025 -9999 0 -10000 0 0
PARP2 0.026 0.007 -9999 0 -10000 0 0
BLM 0.019 0.028 -9999 0 -10000 0 0
Telomerase -0.032 0.12 -9999 0 -0.75 4 4
IRF1 0.031 0.006 -9999 0 -10000 0 0
ESR1 -0.007 0.14 -9999 0 -0.58 12 12
KU/TER 0.037 0.013 -9999 0 -10000 0 0
ATM/TRF2 0.038 0.012 -9999 0 -10000 0 0
ubiquitin-dependent protein catabolic process 0.015 0.079 -9999 0 -0.37 5 5
HPV-16 E6/E6AP/NFX1/SIN3/HDAC complex 0.015 0.081 -9999 0 -0.38 5 5
HDAC1 0.026 0.007 -9999 0 -10000 0 0
HDAC2 0.028 0.006 -9999 0 -10000 0 0
ATM 0.01 0.003 -9999 0 -10000 0 0
SMAD3 0.013 0.007 -9999 0 -10000 0 0
ABL1 0.026 0.007 -9999 0 -10000 0 0
MXD1 0.028 0.004 -9999 0 -10000 0 0
MRE11A 0.027 0.005 -9999 0 -10000 0 0
HUS1 0.023 0.011 -9999 0 -10000 0 0
RPS6KB1 0.026 0.008 -9999 0 -10000 0 0
TERT/NF kappa B1/14-3-3 -0.12 0.13 -9999 0 -0.79 2 2
NR2F2 0.027 0.005 -9999 0 -10000 0 0
MAPK3 -0.004 0.014 -9999 0 -10000 0 0
MAPK1 -0.004 0.014 -9999 0 -10000 0 0
TGFB1/TGF beta receptor Type II 0.027 0.01 -9999 0 -10000 0 0
NFKB1 0.027 0.006 -9999 0 -10000 0 0
HNRNPC 0.026 0.007 -9999 0 -10000 0 0
DNA damage response signal transduction by p53 class mediator resulting in induction of apoptosis 0.01 0.003 -9999 0 -10000 0 0
NBN 0.027 0.005 -9999 0 -10000 0 0
EGFR 0.022 0.011 -9999 0 -10000 0 0
mol:Oestrogen 0 0 -9999 0 -10000 0 0
EGF/EGFR -0.38 0.18 -9999 0 -0.44 187 187
MYC 0.027 0.011 -9999 0 -10000 0 0
IL2 0.015 0.018 -9999 0 -10000 0 0
KU 0.037 0.013 -9999 0 -10000 0 0
RAD50 0.027 0.005 -9999 0 -10000 0 0
HSP90AA1 0.026 0.008 -9999 0 -10000 0 0
TGFB1 0.027 0.01 -9999 0 -10000 0 0
TRF2/BLM 0.03 0.027 -9999 0 -10000 0 0
FRAP1 0 0 -9999 0 -10000 0 0
KU/TERT -0.15 0.13 -9999 0 -0.78 2 2
SP1/HDAC2 0.04 0.012 -9999 0 -10000 0 0
PINX1 0.027 0.006 -9999 0 -10000 0 0
Telomerase/EST1A -0.14 0.12 -9999 0 -0.72 2 2
Smad3/Myc 0.028 0.011 -9999 0 -10000 0 0
911 complex 0.044 0.024 -9999 0 -10000 0 0
IFNG 0.019 0.026 -9999 0 -10000 0 0
Telomerase/PinX1 -0.14 0.12 -9999 0 -0.71 2 2
Telomerase/AKT1/mTOR/p70S6K -0.038 0.11 -9999 0 -0.52 6 6
SIN3B 0.028 0.002 -9999 0 -10000 0 0
YWHAE 0.026 0.008 -9999 0 -10000 0 0
Telomerase/EST1B -0.14 0.12 -9999 0 -0.71 2 2
response to DNA damage stimulus 0.001 0.018 -9999 0 -10000 0 0
MRN complex/TRF2/Rap1 0.07 0.027 -9999 0 -10000 0 0
TRF2/WRN 0.036 0.013 -9999 0 -10000 0 0
Telomerase/hnRNP C1/C2 -0.14 0.12 -9999 0 -0.71 2 2
E2F1 -0.003 0.046 -9999 0 -10000 0 0
ZNFX1 0.027 0.006 -9999 0 -10000 0 0
PIF1 0.017 0.031 -9999 0 -10000 0 0
NCL 0.027 0.005 -9999 0 -10000 0 0
DKC1 0.028 0.002 -9999 0 -10000 0 0
telomeric DNA binding 0 0 -9999 0 -10000 0 0
IL23-mediated signaling events

Figure S53.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S53.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CCL2 -0.012 0.29 -10000 0 -0.96 10 10
IL23A -0.019 0.29 -10000 0 -1 9 9
NF kappa B1 p50/RelA/I kappa B alpha 0.01 0.28 -10000 0 -0.92 10 10
positive regulation of T cell mediated cytotoxicity -0.016 0.3 -10000 0 -0.96 12 12
ITGA3 -0.003 0.27 -10000 0 -0.89 9 9
IL17F 0.006 0.21 0.49 3 -0.62 9 12
IL12B 0.023 0.039 -10000 0 -10000 0 0
STAT1 (dimer) -0.012 0.29 -10000 0 -0.95 11 11
CD4 -0.007 0.27 -10000 0 -0.92 9 9
IL23 -0.008 0.29 -10000 0 -1 9 9
IL23R -0.006 0.16 -10000 0 -0.7 7 7
IL1B -0.025 0.31 -10000 0 -1.1 10 10
T-helper cell lineage commitment 0 0 -10000 0 -10000 0 0
IL24 -0.015 0.27 -10000 0 -0.92 9 9
TYK2 0.024 0.032 -10000 0 -10000 0 0
STAT4 0.02 0.027 -10000 0 -10000 0 0
STAT3 0.026 0.008 -10000 0 -10000 0 0
IL18RAP 0.015 0.034 -10000 0 -10000 0 0
IL12RB1 0.018 0.039 -10000 0 -10000 0 0
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
IL12Rbeta1/TYK2 0.03 0.045 -10000 0 -10000 0 0
IL23R/JAK2 0.014 0.15 -10000 0 -0.61 6 6
positive regulation of chronic inflammatory response -0.016 0.3 -10000 0 -0.96 12 12
natural killer cell activation -0.001 0.006 -10000 0 -10000 0 0
JAK2 0.026 0.038 -10000 0 -10000 0 0
PIK3R1 0.028 0.004 -10000 0 -10000 0 0
NFKB1 0.027 0.007 -10000 0 -10000 0 0
RELA 0.029 0.003 -10000 0 -10000 0 0
positive regulation of dendritic cell antigen processing and presentation -0.005 0.28 -10000 0 -0.95 9 9
ALOX12B -0.007 0.26 -10000 0 -0.85 10 10
CXCL1 -0.043 0.32 -10000 0 -1 15 15
T cell proliferation -0.016 0.3 -10000 0 -0.96 12 12
NFKBIA 0.027 0.008 -10000 0 -10000 0 0
IL17A 0.018 0.17 0.37 1 -0.49 8 9
PI3K -0.002 0.28 -10000 0 -0.92 11 11
IFNG 0.002 0.03 0.1 2 -0.11 5 7
STAT3 (dimer) 0.004 0.27 -10000 0 -0.86 10 10
IL18R1 0.025 0.047 -10000 0 -0.66 1 1
IL23/IL23R/JAK2/TYK2/SOCS3 0.01 0.18 -10000 0 -0.66 2 2
IL18/IL18R 0.043 0.045 -10000 0 -0.43 1 1
macrophage activation -0.002 0.014 -10000 0 -0.042 9 9
TNF -0.021 0.29 -10000 0 -1 10 10
STAT3/STAT4 -0.006 0.27 -10000 0 -0.87 11 11
STAT4 (dimer) -0.013 0.29 -10000 0 -0.93 12 12
IL18 0.026 0.013 -10000 0 -10000 0 0
IL19 -0.017 0.27 -10000 0 -0.92 9 9
STAT5A (dimer) -0.017 0.28 -10000 0 -0.9 11 11
STAT1 0.027 0.01 -10000 0 -10000 0 0
SOCS3 0.021 0.049 -10000 0 -0.66 1 1
CXCL9 -0.022 0.29 -10000 0 -0.95 11 11
MPO -0.002 0.27 -10000 0 -0.88 8 8
positive regulation of humoral immune response -0.016 0.3 -10000 0 -0.96 12 12
IL23/IL23R/JAK2/TYK2 -0.018 0.3 -10000 0 -1 11 11
IL6 -0.046 0.42 -10000 0 -1.1 24 24
STAT5A 0.026 0.008 -10000 0 -10000 0 0
IL2 0.004 0.024 -10000 0 -10000 0 0
positive regulation of tyrosine phosphorylation of STAT protein -0.001 0.006 -10000 0 -10000 0 0
CD3E -0.019 0.28 -10000 0 -0.98 9 9
keratinocyte proliferation -0.016 0.3 -10000 0 -0.96 12 12
NOS2 -0.061 0.39 -10000 0 -1.1 22 22
PDGFR-beta signaling pathway

Figure S54.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S54.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
S1P1/Sphingosine-1-phosphate -0.003 0.12 -10000 0 -0.47 10 10
PDGFB-D/PDGFRB/SLAP 0.015 0.11 -10000 0 -0.5 9 9
PDGFB-D/PDGFRB/APS/CBL 0.025 0.091 -10000 0 -0.42 7 7
AKT1 0.022 0.15 0.53 12 -10000 0 12
mol:PI-4-5-P2 0 0.001 -10000 0 -10000 0 0
mol:Sphingosine-1-phosphate -0.001 0.13 -10000 0 -0.5 10 10
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
FGR -0.039 0.16 0.34 1 -0.49 15 16
mol:Ca2+ 0.003 0.15 0.34 4 -0.55 10 14
MYC 0.044 0.14 0.47 7 -0.42 2 9
SHC1 0.027 0.005 -10000 0 -10000 0 0
HRAS/GDP 0.02 0.086 -10000 0 -0.36 9 9
LRP1/PDGFRB/PDGFB 0.027 0.1 -10000 0 -0.42 10 10
GRB10 0.023 0.011 -10000 0 -10000 0 0
PTPN11 0.027 0.006 -10000 0 -10000 0 0
GO:0007205 0.002 0.15 0.35 3 -0.56 10 13
PTEN 0.028 0.003 -10000 0 -10000 0 0
GRB2 0.026 0.008 -10000 0 -10000 0 0
GRB7 0.026 0.008 -10000 0 -10000 0 0
PDGFB-D/PDGFRB/SHP2 0.017 0.11 -10000 0 -0.49 9 9
PDGFB-D/PDGFRB/GRB10 0.014 0.096 -10000 0 -0.42 9 9
cell cycle arrest 0.015 0.11 -10000 0 -0.5 9 9
HRAS 0.028 0.003 -10000 0 -10000 0 0
HIF1A 0.019 0.14 0.51 12 -10000 0 12
GAB1 0.002 0.15 0.38 4 -0.52 10 14
mol:GTP 0 0 -10000 0 -10000 0 0
DNM2 0.003 0.14 0.38 5 -0.48 9 14
PDGFB-D/PDGFRB 0.031 0.1 -10000 0 -0.43 9 9
mol:GDP 0 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB/LMW-PTP 0.017 0.11 -10000 0 -0.49 9 9
S1P1/Sphingosine-1-phosphate/PDGFB-D/PDGFRB 0 0.1 -10000 0 -0.49 7 7
positive regulation of MAPKKK cascade 0.017 0.11 -10000 0 -0.49 9 9
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
mol:IP3 0.002 0.15 0.36 3 -0.56 10 13
E5 0 0.001 -10000 0 -10000 0 0
CSK 0.026 0.01 -10000 0 -10000 0 0
PDGFB-D/PDGFRB/GRB7 0.018 0.1 -10000 0 -0.44 9 9
SHB 0.027 0.006 -10000 0 -10000 0 0
BLK -0.017 0.11 -10000 0 -0.43 11 11
PTPN2 0.027 0.009 -10000 0 -10000 0 0
PDGFB-D/PDGFRB/SNX15 0.018 0.11 -10000 0 -0.49 9 9
BCAR1 0.026 0.007 -10000 0 -10000 0 0
VAV2 0.006 0.15 0.4 4 -0.51 10 14
CBL 0.027 0.005 -10000 0 -10000 0 0
PDGFB-D/PDGFRB/DEP1 0.017 0.11 -10000 0 -0.49 9 9
LCK -0.031 0.15 0.34 1 -0.49 13 14
PDGFRB -0.001 0.14 -10000 0 -0.66 9 9
ACP1 0.027 0.005 -10000 0 -10000 0 0
HCK -0.008 0.093 -10000 0 -0.41 10 10
ABL1 0.002 0.14 0.34 5 -0.47 11 16
PDGFB-D/PDGFRB/CBL -0.001 0.16 0.37 2 -0.56 12 14
PTPN1 0.027 0.007 -10000 0 -10000 0 0
SNX15 0.028 0.002 -10000 0 -10000 0 0
STAT3 0.026 0.008 -10000 0 -10000 0 0
STAT1 0.027 0.01 -10000 0 -10000 0 0
cell proliferation 0.044 0.14 0.46 7 -0.38 2 9
SLA 0.024 0.017 -10000 0 -10000 0 0
actin cytoskeleton reorganization 0.026 0.094 0.38 4 -0.36 7 11
SRC -0.004 0.086 -10000 0 -0.4 9 9
PI3K -0.002 0.062 -10000 0 -0.34 6 6
PDGFB-D/PDGFRB/GRB7/SHC 0.032 0.091 -10000 0 -0.43 7 7
SH2B2 0.023 0.011 -10000 0 -10000 0 0
PLCgamma1/SPHK1 -0.002 0.13 -10000 0 -0.52 10 10
LYN -0.008 0.095 -10000 0 -0.42 10 10
LRP1 0.027 0.005 -10000 0 -10000 0 0
SOS1 0.027 0.004 -10000 0 -10000 0 0
STAT5B 0.026 0.008 -10000 0 -10000 0 0
STAT5A 0.026 0.008 -10000 0 -10000 0 0
NCK1-2/p130 Cas 0.057 0.087 -10000 0 -0.36 7 7
SPHK1 -0.017 0.048 -10000 0 -10000 0 0
EDG1 0 0.003 -10000 0 -10000 0 0
mol:DAG 0.002 0.15 0.36 3 -0.56 10 13
PLCG1 0.002 0.15 0.39 2 -0.58 10 12
NHERF/PDGFRB 0.032 0.086 -10000 0 -0.43 6 6
YES1 -0.035 0.17 0.34 1 -0.53 19 20
cell migration 0.032 0.085 -10000 0 -0.43 6 6
SHC/Grb2/SOS1 0.054 0.088 -10000 0 -0.36 7 7
SLC9A3R2 0.025 0.008 -10000 0 -10000 0 0
SLC9A3R1 0.026 0.008 -10000 0 -10000 0 0
NHERF1-2/PDGFRB/PTEN 0.045 0.084 -10000 0 -0.39 6 6
FYN -0.013 0.12 -10000 0 -0.47 10 10
DOK1 0.004 0.09 -10000 0 -0.39 9 9
HRAS/GTP 0.021 0.002 -10000 0 -10000 0 0
PDGFB 0.022 0.048 -10000 0 -0.66 1 1
RAC1 0.041 0.16 0.45 7 -0.5 6 13
PRKCD 0.004 0.087 -10000 0 -0.4 8 8
FER 0.006 0.092 -10000 0 -0.4 9 9
MAPKKK cascade 0 0.12 0.42 8 -0.36 7 15
RASA1 0.006 0.092 -10000 0 -0.4 9 9
NCK1 0.027 0.006 -10000 0 -10000 0 0
NCK2 0.028 0.003 -10000 0 -10000 0 0
p62DOK/Csk 0.017 0.086 -10000 0 -0.37 9 9
PDGFB-D/PDGFRB/SHB 0.017 0.11 -10000 0 -0.49 9 9
chemotaxis 0.002 0.14 0.34 5 -0.46 11 16
STAT1-3-5/STAT1-3-5 0.045 0.079 -10000 0 -0.36 7 7
Bovine Papilomavirus E5/PDGFRB -0.001 0.1 -10000 0 -0.49 9 9
PTPRJ 0.028 0.004 -10000 0 -10000 0 0
Visual signal transduction: Rods

Figure S55.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S55.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:K + 0.028 0.004 -10000 0 -10000 0 0
GNAT1/GTP 0.013 0.008 -10000 0 -10000 0 0
Metarhodopsin II/Arrestin 0.025 0.011 -10000 0 -10000 0 0
PDE6G/GNAT1/GTP 0.019 0.064 -10000 0 -0.43 4 4
mol:GTP 0 0 -10000 0 -10000 0 0
absorption of light 0 0 -10000 0 -10000 0 0
GNAT1 -0.008 0.021 -10000 0 -10000 0 0
GRK1 -0.008 0.02 -10000 0 -10000 0 0
CNG Channel -0.062 0.17 -10000 0 -0.36 47 47
mol:Na + -0.054 0.16 -10000 0 -0.36 40 40
mol:ADP -0.008 0.02 -10000 0 -10000 0 0
RGS9-1/Gbeta5/R9AP 0.039 0.07 -10000 0 -0.44 4 4
mol:GDP 0 0 -10000 0 -10000 0 0
cGMP/CNG Channel -0.044 0.17 -10000 0 -0.37 40 40
CNGB1 0.011 0.026 -10000 0 -10000 0 0
RDH5 0.014 0.07 -10000 0 -0.66 2 2
SAG -0.016 0.01 -10000 0 -10000 0 0
mol:Ca2+ -0.075 0.17 0.4 8 -0.36 39 47
Na + (4 Units) -0.056 0.15 -10000 0 -0.35 40 40
RGS9 0.014 0.082 -10000 0 -0.66 3 3
GNB1/GNGT1 0.021 0.027 -10000 0 -10000 0 0
GNAT1/GDP 0.043 0.064 -10000 0 -0.38 4 4
GUCY2D 0.01 0.03 -10000 0 -10000 0 0
GNGT1 0.001 0.03 -10000 0 -10000 0 0
GUCY2F -0.015 0.013 -10000 0 -10000 0 0
GNB5 0.027 0.005 -10000 0 -10000 0 0
mol:GMP (4 units) 0.002 0.064 -10000 0 -0.38 5 5
mol:11-cis-retinal 0.014 0.07 -10000 0 -0.66 2 2
mol:cGMP 0.032 0.033 -10000 0 -10000 0 0
GNB1 0.025 0.008 -10000 0 -10000 0 0
Rhodopsin 0.023 0.057 -10000 0 -0.5 2 2
SLC24A1 0.028 0.004 -10000 0 -10000 0 0
CNGA1 -0.15 0.29 -10000 0 -0.63 55 55
Metarhodopsin II 0.024 0.012 -10000 0 -10000 0 0
mol:Ca ++ 0 0 -10000 0 -10000 0 0
GC1/GCAP Family 0.05 0.028 -10000 0 -10000 0 0
RGS9BP 0.023 0.048 -10000 0 -0.66 1 1
Metarhodopsin II/Transducin 0.006 0.018 -10000 0 -10000 0 0
GCAP Family/Ca ++ 0.04 0.02 -10000 0 -10000 0 0
PDE6A/B 0.03 0.046 -10000 0 -0.37 2 2
mol:Pi 0.038 0.07 -10000 0 -0.44 4 4
mol:all-trans-retinal 0 0 -10000 0 -10000 0 0
Transducin 0.026 0.03 -10000 0 -10000 0 0
PDE6B 0.021 0.055 -10000 0 -0.5 2 2
PDE6A 0.014 0.025 -10000 0 -10000 0 0
PDE6G 0.012 0.094 -10000 0 -0.66 4 4
RHO 0.002 0.025 -10000 0 -10000 0 0
PDE6 0.049 0.095 -10000 0 -0.37 9 9
GUCA1A -0.002 0.025 -10000 0 -10000 0 0
GC2/GCAP Family 0.052 0.021 -10000 0 -10000 0 0
GUCA1C 0.008 0.023 -10000 0 -10000 0 0
GUCA1B 0.027 0.007 -10000 0 -10000 0 0
Regulation of Androgen receptor activity

Figure S56.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S56.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.012 0.005 -10000 0 -10000 0 0
SMARCC1 0.005 0.048 -10000 0 -0.65 1 1
REL 0.024 0.048 -10000 0 -0.66 1 1
HDAC7 -0.12 0.11 -10000 0 -0.43 2 2
JUN 0.026 0.007 -10000 0 -10000 0 0
EP300 0.025 0.009 -10000 0 -10000 0 0
KAT2B 0.027 0.006 -10000 0 -10000 0 0
KAT5 0.028 0.002 -10000 0 -10000 0 0
MAPK14 -0.016 0.025 -10000 0 -10000 0 0
FOXO1 0.027 0.006 -10000 0 -10000 0 0
T-DHT/AR -0.11 0.13 -10000 0 -0.44 2 2
MAP2K6 -0.006 0.026 -10000 0 -10000 0 0
BRM/BAF57 0.036 0.015 -10000 0 -10000 0 0
MAP2K4 -0.006 0.026 -10000 0 -10000 0 0
SMARCA2 0.026 0.007 -10000 0 -10000 0 0
PDE9A -0.17 0.21 -10000 0 -0.78 11 11
NCOA2 -0.031 0.19 -10000 0 -0.66 18 18
CEBPA 0.017 0.054 -10000 0 -0.66 1 1
EHMT2 0.027 0.006 -10000 0 -10000 0 0
cell proliferation -0.14 0.21 0.5 8 -0.49 25 33
NR0B1 -0.007 0.038 -10000 0 -10000 0 0
EGR1 -0.028 0.19 -10000 0 -0.66 17 17
RXRs/9cRA 0.043 0.019 -10000 0 -10000 0 0
AR/RACK1/Src -0.037 0.092 0.32 3 -0.35 4 7
AR/GR -0.015 0.094 0.24 6 -0.34 9 15
GNB2L1 0.027 0.005 -10000 0 -10000 0 0
PKN1 0.028 0.002 -10000 0 -10000 0 0
RCHY1 0.027 0.006 -10000 0 -10000 0 0
epidermal growth factor receptor activity 0 0 -10000 0 -10000 0 0
MAPK8 -0.025 0.059 -10000 0 -0.39 4 4
T-DHT/AR/TIF2/CARM1 -0.059 0.16 0.33 5 -0.5 17 22
SRC -0.042 0.049 0.19 2 -0.38 1 3
NR3C1 0.027 0.005 -10000 0 -10000 0 0
KLK3 -0.058 0.18 -10000 0 -0.68 6 6
APPBP2 -0.006 0.026 -10000 0 -10000 0 0
TRIM24 0.022 0.012 -10000 0 -10000 0 0
T-DHT/AR/TIP60 -0.039 0.1 0.3 7 -0.36 4 11
TMPRSS2 -0.76 0.53 -10000 0 -1.1 138 138
RXRG -0.003 0.022 -10000 0 -10000 0 0
mol:9cRA 0 0.001 -10000 0 -10000 0 0
RXRA 0.026 0.007 -10000 0 -10000 0 0
RXRB 0.027 0.006 -10000 0 -10000 0 0
CARM1 0.028 0.003 -10000 0 -10000 0 0
NR2C2 0.025 0.026 -10000 0 -0.34 1 1
KLK2 -0.043 0.13 0.33 6 -0.5 5 11
AR -0.03 0.081 -10000 0 -0.36 10 10
SENP1 0.027 0.006 -10000 0 -10000 0 0
HSP90AA1 0.026 0.008 -10000 0 -10000 0 0
MDM2 0.027 0.006 -10000 0 -10000 0 0
SRY 0 0.002 0.033 1 -10000 0 1
GATA2 -0.083 0.25 -10000 0 -0.66 34 34
MYST2 0 0 -10000 0 -10000 0 0
HOXB13 -0.005 0.042 -10000 0 -10000 0 0
T-DHT/AR/RACK1/Src -0.036 0.1 0.33 5 -0.36 4 9
positive regulation of transcription -0.083 0.25 -10000 0 -0.66 34 34
DNAJA1 -0.007 0.027 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.017 0.007 -10000 0 -10000 0 0
NCOA1 0.034 0.016 -10000 0 -10000 0 0
SPDEF 0.015 0.028 -10000 0 -10000 0 0
T-DHT/AR/TIF2 -0.035 0.12 0.29 5 -0.46 7 12
T-DHT/AR/Hsp90 -0.035 0.099 0.3 7 -0.36 4 11
GSK3B 0.023 0.009 -10000 0 -10000 0 0
NR2C1 0.027 0.005 -10000 0 -10000 0 0
mol:T-DHT -0.046 0.047 -10000 0 -0.4 1 1
SIRT1 0.028 0.003 -10000 0 -10000 0 0
ZMIZ2 0.022 0.011 -10000 0 -10000 0 0
POU2F1 -0.052 0.067 -10000 0 -10000 0 0
T-DHT/AR/DAX-1 -0.047 0.1 0.31 6 -0.38 4 10
CREBBP 0.025 0.008 -10000 0 -10000 0 0
SMARCE1 0.026 0.009 -10000 0 -10000 0 0
Sphingosine 1-phosphate (S1P) pathway

Figure S57.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S57.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPHK2 0.028 0.003 -9999 0 -10000 0 0
SPHK1 -0.018 0.048 -9999 0 -10000 0 0
GNAI2 0.027 0.007 -9999 0 -10000 0 0
mol:S1P 0.004 0.012 -9999 0 -10000 0 0
GNAO1 -0.011 0.15 -9999 0 -0.66 11 11
mol:Sphinganine-1-P -0.014 0.03 -9999 0 -10000 0 0
growth factor activity 0 0 -9999 0 -10000 0 0
S1P/S1P2/G12/G13 0.045 0.033 -9999 0 -10000 0 0
GNAI3 0.027 0.006 -9999 0 -10000 0 0
G12/G13 0.031 0.018 -9999 0 -10000 0 0
S1PR3 -0.037 0.2 -9999 0 -0.64 20 20
S1PR2 0.028 0.003 -9999 0 -10000 0 0
EDG1 0 0 -9999 0 -10000 0 0
S1P1/S1P 0.001 0.013 -9999 0 -10000 0 0
S1PR5 0.019 0.068 -9999 0 -0.66 2 2
S1PR4 0.026 0.012 -9999 0 -10000 0 0
GNAI1 0.019 0.048 -9999 0 -0.66 1 1
S1P/S1P5/G12 0.035 0.05 -9999 0 -0.35 2 2
S1P/S1P3/Gq -0.079 0.19 -9999 0 -0.38 46 46
S1P/S1P4/Gi 0.011 0.094 -9999 0 -0.3 12 12
GNAQ 0.026 0.007 -9999 0 -10000 0 0
GNAZ 0.025 0.008 -9999 0 -10000 0 0
GNA14 -0.11 0.27 -9999 0 -0.64 44 44
GNA15 0.022 0.023 -9999 0 -10000 0 0
GNA12 0.023 0.011 -9999 0 -10000 0 0
GNA13 0.026 0.008 -9999 0 -10000 0 0
GNA11 0.012 0.1 -9999 0 -0.66 5 5
ABCC1 0.026 0.008 -9999 0 -10000 0 0
HIF-1-alpha transcription factor network

Figure S58.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S58.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PKM2 0.039 0.27 -10000 0 -1.1 4 4
HDAC7 0.028 0.006 -10000 0 -10000 0 0
HIF1A/ARNT/Cbp/p300/Src-1 0.094 0.25 -10000 0 -0.75 3 3
SMAD4 0.027 0.008 -10000 0 -10000 0 0
ID2 0.039 0.27 -10000 0 -1.1 4 4
AP1 -0.035 0.18 -10000 0 -0.44 33 33
ABCG2 0.036 0.28 -10000 0 -1 5 5
HIF1A 0.028 0.067 -10000 0 -10000 0 0
TFF3 -0.017 0.34 -10000 0 -0.89 14 14
GATA2 -0.082 0.25 -10000 0 -0.66 34 34
AKT1 0.033 0.066 -10000 0 -10000 0 0
response to hypoxia 0.013 0.056 -10000 0 -10000 0 0
MCL1 0.038 0.27 -10000 0 -0.98 5 5
NDRG1 0.04 0.27 -10000 0 -1.1 4 4
SERPINE1 -0.009 0.28 -10000 0 -0.94 8 8
FECH 0.032 0.27 -10000 0 -1.1 4 4
FURIN 0.039 0.27 -10000 0 -1.1 4 4
NCOA2 -0.03 0.19 -10000 0 -0.66 18 18
EP300 0.039 0.08 -10000 0 -0.34 2 2
HMOX1 0.03 0.28 -10000 0 -1.2 4 4
BHLHE40 0.036 0.27 -10000 0 -0.96 5 5
BHLHE41 0.035 0.27 -10000 0 -1 4 4
HIF1A/ARNT/SMAD3/SMAD4/SP1 0.081 0.11 -10000 0 -10000 0 0
ENG 0.042 0.083 0.34 1 -10000 0 1
JUN 0.027 0.007 -10000 0 -10000 0 0
RORA 0.037 0.28 -10000 0 -0.98 5 5
ABCB1 -0.049 0.26 -10000 0 -1.1 11 11
TFRC 0.039 0.27 -10000 0 -1 4 4
CXCR4 0.038 0.27 -10000 0 -1.1 4 4
TF 0.03 0.28 -10000 0 -1 4 4
CITED2 0.04 0.27 -10000 0 -1.1 4 4
HIF1A/ARNT 0.094 0.34 -10000 0 -1.2 4 4
LDHA 0.013 0.1 -10000 0 -0.71 3 3
ETS1 0.037 0.27 -10000 0 -1.1 4 4
PGK1 0.04 0.27 -10000 0 -0.98 5 5
NOS2 0.014 0.31 -10000 0 -0.93 10 10
ITGB2 0.026 0.27 -10000 0 -1.1 4 4
ALDOA 0.034 0.26 -10000 0 -1 4 4
Cbp/p300/CITED2 0.057 0.28 -10000 0 -1 4 4
FOS -0.071 0.23 -10000 0 -0.6 33 33
HK2 0.027 0.27 -10000 0 -1 5 5
SP1 0.025 0.036 -10000 0 -10000 0 0
GCK 0.03 0.16 -10000 0 -0.62 2 2
HK1 0.039 0.27 -10000 0 -1.1 4 4
NPM1 0.037 0.27 -10000 0 -1.1 4 4
EGLN1 0.036 0.27 -10000 0 -1.1 4 4
CREB1 0.033 0.005 -10000 0 -10000 0 0
PGM1 0.036 0.27 -10000 0 -0.98 5 5
SMAD3 0.029 0.004 -10000 0 -10000 0 0
EDN1 -0.047 0.23 -10000 0 -0.68 15 15
IGFBP1 -0.022 0.29 -10000 0 -0.94 8 8
VEGFA 0.069 0.21 0.52 1 -0.7 1 2
HIF1A/JAB1 0.041 0.054 -10000 0 -10000 0 0
CP 0.012 0.3 -10000 0 -0.87 9 9
CXCL12 -0.001 0.35 -10000 0 -0.9 16 16
COPS5 0.028 0.005 -10000 0 -10000 0 0
SMAD3/SMAD4 0.039 0.013 -10000 0 -10000 0 0
BNIP3 0.039 0.27 -10000 0 -0.98 5 5
EGLN3 0.041 0.27 -10000 0 -1.1 4 4
CA9 0.025 0.27 -10000 0 -1 5 5
TERT 0.03 0.27 -10000 0 -1.1 4 4
ENO1 0.036 0.27 -10000 0 -1.1 4 4
PFKL 0.031 0.27 -10000 0 -1.1 4 4
NCOA1 0.028 0.005 -10000 0 -10000 0 0
ADM 0.035 0.28 -10000 0 -1.1 5 5
ARNT 0.029 0.067 -10000 0 -10000 0 0
HNF4A -0.059 0.23 -10000 0 -0.66 27 27
ADFP 0.027 0.26 -10000 0 -0.92 6 6
SLC2A1 0.065 0.21 0.52 1 -0.7 1 2
LEP 0.003 0.25 -10000 0 -1 4 4
HIF1A/ARNT/Cbp/p300 0.086 0.26 -10000 0 -0.77 3 3
EPO 0.009 0.22 -10000 0 -0.82 4 4
CREBBP 0.041 0.07 -10000 0 -0.32 1 1
HIF1A/ARNT/Cbp/p300/HDAC7 0.096 0.25 -10000 0 -0.81 1 1
PFKFB3 0.039 0.27 -10000 0 -0.98 5 5
NT5E 0.039 0.28 -10000 0 -1.1 4 4
IFN-gamma pathway

Figure S59.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S59.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 0.059 0.03 -10000 0 -10000 0 0
positive regulation of NF-kappaB transcription factor activity 0 0.002 -10000 0 -10000 0 0
CRKL 0.026 0.008 -10000 0 -10000 0 0
STAT1 (dimer)/Cbp/p300 0.047 0.04 0.3 3 -10000 0 3
IFN-gammaR/JAK1/JAK1/JAK2/JAK2 0.054 0.028 -10000 0 -10000 0 0
antigen processing and presentation of peptide antigen via MHC class I -0.058 0.086 -10000 0 -10000 0 0
CaM/Ca2+ 0.058 0.032 -10000 0 -10000 0 0
RAP1A 0.027 0.006 -10000 0 -10000 0 0
STAT1 (dimer)/SHP2 0.025 0.026 -10000 0 -10000 0 0
AKT1 0.015 0.073 0.36 7 -10000 0 7
MAP2K1 0.002 0.056 0.29 7 -10000 0 7
MAP3K11 0.022 0.058 0.29 8 -10000 0 8
IFNGR1 0.029 0.009 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
CaM/Ca2+/CAMKII -0.2 0.25 -10000 0 -0.45 100 100
Rap1/GTP 0.016 0.017 -10000 0 -10000 0 0
CRKL/C3G 0.036 0.014 -10000 0 -10000 0 0
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 /TC-PTP 0.066 0.035 -10000 0 -10000 0 0
CEBPB 0.018 0.12 0.37 7 -0.57 1 8
STAT3 0.026 0.008 -10000 0 -10000 0 0
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 0.059 0.12 -10000 0 -1.1 2 2
STAT1 0.02 0.055 0.29 7 -10000 0 7
CALM1 0.026 0.007 -10000 0 -10000 0 0
IFN-gamma (dimer) 0.005 0.032 -10000 0 -10000 0 0
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
STAT1 (dimer)/PIAS1 0.034 0.055 0.29 7 -10000 0 7
CEBPB/PTGES2/Cbp/p300 0.025 0.064 -10000 0 -0.35 1 1
mol:Ca2+ 0.055 0.028 -10000 0 -10000 0 0
MAPK3 0.018 0.06 -10000 0 -0.58 1 1
STAT1 (dimer) -0.068 0.12 -10000 0 -10000 0 0
MAPK1 -0.038 0.23 0.42 1 -0.71 19 20
JAK2 0.029 0.011 -10000 0 -10000 0 0
PIK3R1 0.028 0.004 -10000 0 -10000 0 0
JAK1 0.029 0.01 -10000 0 -10000 0 0
CAMK2D 0.027 0.006 -10000 0 -10000 0 0
DAPK1 0.019 0.086 0.31 8 -0.32 1 9
SMAD7 -0.014 0.084 0.28 9 -10000 0 9
CBL/CRKL/C3G 0.045 0.057 0.29 8 -10000 0 8
PI3K 0.057 0.031 -10000 0 -10000 0 0
IFNG 0.005 0.032 -10000 0 -10000 0 0
apoptosis -0.016 0.11 -10000 0 -0.42 10 10
CAMK2G 0.028 0.003 -10000 0 -10000 0 0
STAT3 (dimer) 0.026 0.008 -10000 0 -10000 0 0
CAMK2A -0.31 0.33 -10000 0 -0.65 100 100
CAMK2B 0.002 0.096 -10000 0 -0.66 4 4
FRAP1 0.005 0.071 0.35 7 -10000 0 7
PRKCD 0.001 0.056 0.31 5 -10000 0 5
RAP1B 0.027 0.006 -10000 0 -10000 0 0
negative regulation of cell growth -0.058 0.086 -10000 0 -10000 0 0
PTPN2 0.026 0.008 -10000 0 -10000 0 0
EP300 0.026 0.009 -10000 0 -10000 0 0
IRF1 0.021 0.077 0.46 3 -0.39 1 4
STAT1 (dimer)/PIASy 0.032 0.055 0.29 7 -10000 0 7
SOCS1 0.014 0.13 -10000 0 -1.3 2 2
mol:GDP 0.041 0.053 0.27 8 -10000 0 8
CASP1 -0.015 0.085 0.28 9 -10000 0 9
PTGES2 0.027 0.007 -10000 0 -10000 0 0
IRF9 0.029 0.058 0.25 8 -10000 0 8
mol:PI-3-4-5-P3 0.042 0.023 -10000 0 -10000 0 0
RAP1/GDP 0.036 0.021 -10000 0 -10000 0 0
CBL 0.015 0.06 0.29 8 -10000 0 8
MAP3K1 0.021 0.055 0.29 7 -10000 0 7
PIAS1 0.028 0.004 -10000 0 -10000 0 0
PIAS4 0.028 0.003 -10000 0 -10000 0 0
antigen processing and presentation of peptide antigen via MHC class II -0.058 0.086 -10000 0 -10000 0 0
PTPN11 0.011 0.02 -10000 0 -10000 0 0
CREBBP 0.026 0.009 -10000 0 -10000 0 0
RAPGEF1 0.026 0.007 -10000 0 -10000 0 0
ceramide signaling pathway

Figure S60.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S60.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAP4K4 0.006 0.087 -10000 0 -0.42 4 4
BAG4 0.027 0.006 -10000 0 -10000 0 0
BAD 0.009 0.045 0.2 5 -0.18 1 6
NFKBIA 0.026 0.007 -10000 0 -10000 0 0
BIRC3 0.021 0.025 -10000 0 -10000 0 0
BAX 0.009 0.045 0.2 5 -0.18 1 6
EnzymeConsortium:3.1.4.12 0.008 0.032 0.13 7 -0.092 4 11
IKBKB 0.009 0.088 0.26 1 -0.39 4 5
MAP2K2 0.018 0.08 0.27 15 -10000 0 15
MAP2K1 0.019 0.079 0.27 15 -10000 0 15
SMPD1 0.009 0.037 0.15 5 -0.15 3 8
GO:0005551 0 0 -10000 0 -10000 0 0
FADD/Caspase 8 0.012 0.084 -10000 0 -0.37 4 4
MAP2K4 0.019 0.076 0.3 11 -10000 0 11
protein ubiquitination 0.014 0.1 0.36 4 -0.41 4 8
EnzymeConsortium:2.7.1.37 0.021 0.092 0.31 15 -10000 0 15
response to UV 0 0.001 0.004 15 -10000 0 15
RAF1 0.021 0.082 0.28 15 -10000 0 15
CRADD 0.027 0.005 -10000 0 -10000 0 0
mol:ceramide 0.012 0.047 0.18 7 -0.14 4 11
I-kappa-B-alpha/RELA/p50/ubiquitin 0.035 0.01 -10000 0 -10000 0 0
MADD 0.028 0.004 -10000 0 -10000 0 0
MAP3K1 0.012 0.052 0.25 5 -0.18 1 6
TRADD 0.026 0.007 -10000 0 -10000 0 0
RELA/p50 0.028 0.002 -10000 0 -10000 0 0
MAPK3 0.021 0.076 0.26 15 -10000 0 15
MAPK1 0.013 0.083 0.26 14 -10000 0 14
p50/RELA/I-kappa-B-alpha 0.039 0.011 -10000 0 -10000 0 0
FADD 0.008 0.081 -10000 0 -0.38 4 4
KSR1 0.019 0.071 0.26 13 -0.18 1 14
MAPK8 0.01 0.08 0.29 10 -0.29 2 12
TRAF2 0.026 0.007 -10000 0 -10000 0 0
response to radiation 0 0.001 0.004 7 -10000 0 7
CHUK 0.011 0.091 0.27 3 -0.4 4 7
TNF R/SODD 0.038 0.012 -10000 0 -10000 0 0
TNF 0.014 0.07 -10000 0 -0.66 2 2
CYCS 0.025 0.056 0.2 9 -10000 0 9
IKBKG 0.012 0.092 0.27 3 -0.4 4 7
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD 0.008 0.086 -10000 0 -0.44 4 4
RELA 0.028 0.002 -10000 0 -10000 0 0
RIPK1 0.027 0.006 -10000 0 -10000 0 0
AIFM1 0.012 0.044 0.19 5 -10000 0 5
TNF/TNF R/SODD 0.041 0.053 -10000 0 -0.43 2 2
TNFRSF1A 0.027 0.007 -10000 0 -10000 0 0
response to heat 0 0.001 0.004 7 -10000 0 7
CASP8 0.023 0.077 -10000 0 -0.5 4 4
NSMAF 0.007 0.082 -10000 0 -0.41 3 3
response to hydrogen peroxide 0 0.001 0.004 15 -10000 0 15
BCL2 0.026 0.008 -10000 0 -10000 0 0
TCGA08_p53

Figure S61.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S61.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDKN2A -0.032 0.022 -10000 0 -10000 0 0
TP53 -0.01 0.039 -10000 0 -0.19 9 9
Senescence -0.011 0.04 -10000 0 -0.19 10 10
Apoptosis -0.011 0.04 -10000 0 -0.19 10 10
Activated_Oncogenes 0 0 -10000 0 -10000 0 0
MDM2 0.029 0.067 0.32 10 -10000 0 10
MDM4 0.027 0.006 -10000 0 -10000 0 0
EPHB forward signaling

Figure S62.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S62.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Ephrin A5/EPHB2 0 0.12 -10000 0 -0.43 15 15
cell-cell adhesion 0.021 0.05 0.32 5 -10000 0 5
Ephrin B/EPHB2/RasGAP 0.056 0.069 -10000 0 -0.38 4 4
ITSN1 0.026 0.008 -10000 0 -10000 0 0
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
SHC1 0.027 0.005 -10000 0 -10000 0 0
Ephrin B1/EPHB3 -0.062 0.19 -10000 0 -0.42 45 45
Ephrin B1/EPHB1 0.028 0.056 -10000 0 -0.43 3 3
HRAS/GDP 0.014 0.067 -10000 0 -0.35 3 3
Ephrin B/EPHB1/GRB7 0.054 0.083 -10000 0 -0.38 6 6
Endophilin/SYNJ1 -0.007 0.065 -10000 0 -0.35 4 4
KRAS 0.027 0.006 -10000 0 -10000 0 0
Ephrin B/EPHB1/Src 0.053 0.083 -10000 0 -0.38 6 6
endothelial cell migration 0.045 0.026 -10000 0 -10000 0 0
GRB2 0.026 0.008 -10000 0 -10000 0 0
GRB7 0.026 0.008 -10000 0 -10000 0 0
PAK1 -0.002 0.08 0.35 4 -0.36 3 7
HRAS 0.028 0.003 -10000 0 -10000 0 0
RRAS -0.005 0.07 -10000 0 -0.36 4 4
DNM1 -0.002 0.045 -10000 0 -10000 0 0
cell-cell signaling 0 0 -10000 0 -10000 0 0
CRK -0.018 0.07 0.35 1 -0.36 6 7
lamellipodium assembly -0.021 0.05 -10000 0 -0.32 5 5
Ephrin B/EPHB1/Src/p52 SHC/GRB2 0.017 0.053 -10000 0 -0.28 3 3
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
EPHB2 0.024 0.016 -10000 0 -10000 0 0
EPHB3 -0.12 0.28 -10000 0 -0.66 45 45
EPHB1 0.015 0.082 -10000 0 -0.66 3 3
EPHB4 0.023 0.011 -10000 0 -10000 0 0
mol:GDP 0.033 0.11 0.37 12 -0.37 3 15
Ephrin B/EPHB2 0.044 0.064 -10000 0 -0.38 4 4
Ephrin B/EPHB3 -0.039 0.18 -10000 0 -0.38 42 42
JNK cascade -0.009 0.071 0.35 5 -0.37 3 8
Ephrin B/EPHB1 0.041 0.078 -10000 0 -0.38 6 6
RAP1/GDP 0.069 0.12 0.36 10 -0.34 2 12
EFNB2 0.027 0.006 -10000 0 -10000 0 0
EFNB3 0.002 0.097 -10000 0 -0.66 4 4
EFNB1 0.028 0.002 -10000 0 -10000 0 0
Ephrin B2/EPHB1-2 0.038 0.057 -10000 0 -0.4 3 3
RAP1B 0.027 0.006 -10000 0 -10000 0 0
RAP1A 0.027 0.006 -10000 0 -10000 0 0
CDC42/GTP 0.025 0.074 -10000 0 -0.37 3 3
Rap1/GTP 0.007 0.064 -10000 0 -10000 0 0
axon guidance -0.001 0.12 -10000 0 -0.42 15 15
MAPK3 0.013 0.062 -10000 0 -10000 0 0
MAPK1 0.007 0.055 -10000 0 -10000 0 0
Rac1/GDP 0.022 0.09 0.33 3 -0.34 3 6
actin cytoskeleton reorganization -0.006 0.046 -10000 0 -10000 0 0
CDC42/GDP 0.069 0.13 0.36 13 -0.34 3 16
PI3K 0.05 0.029 -10000 0 -10000 0 0
EFNA5 -0.022 0.18 -10000 0 -0.66 15 15
Ephrin B2/EPHB4 0.029 0.016 -10000 0 -10000 0 0
Ephrin B/EPHB2/Intersectin/N-WASP 0.009 0.056 -10000 0 -0.33 4 4
CDC42 0.026 0.008 -10000 0 -10000 0 0
RAS family/GTP 0.005 0.062 -10000 0 -10000 0 0
PTK2 -0.001 0.053 0.53 2 -10000 0 2
MAP4K4 -0.009 0.072 0.36 5 -0.38 3 8
SRC 0.026 0.009 -10000 0 -10000 0 0
KALRN 0.027 0.005 -10000 0 -10000 0 0
Intersectin/N-WASP 0.031 0.018 -10000 0 -10000 0 0
neuron projection morphogenesis 0.058 0.15 0.36 34 -10000 0 34
MAP2K1 0.008 0.052 -10000 0 -10000 0 0
WASL 0.022 0.011 -10000 0 -10000 0 0
Ephrin B1/EPHB1-2/NCK1 0.055 0.06 -10000 0 -0.4 3 3
cell migration 0.037 0.12 0.43 9 -10000 0 9
NRAS 0.027 0.006 -10000 0 -10000 0 0
SYNJ1 -0.007 0.066 -10000 0 -0.36 4 4
PXN 0.027 0.006 -10000 0 -10000 0 0
TF -0.016 0.07 -10000 0 -0.35 6 6
HRAS/GTP 0.034 0.071 -10000 0 -0.34 6 6
Ephrin B1/EPHB1-2 0.038 0.057 -10000 0 -0.4 3 3
cell adhesion mediated by integrin 0.04 0.088 0.4 4 -10000 0 4
RAC1 0.022 0.011 -10000 0 -10000 0 0
mol:GTP 0.035 0.074 -10000 0 -0.36 6 6
RAC1-CDC42/GTP -0.061 0.14 -10000 0 -0.51 4 4
RASA1 0.027 0.005 -10000 0 -10000 0 0
RAC1-CDC42/GDP 0.031 0.089 0.32 3 -0.34 2 5
ruffle organization 0.038 0.14 0.33 35 -10000 0 35
NCK1 0.027 0.006 -10000 0 -10000 0 0
receptor internalization -0.015 0.063 -10000 0 -0.34 4 4
Ephrin B/EPHB2/KALRN 0.058 0.065 -10000 0 -0.38 3 3
ROCK1 -0.069 0.17 -10000 0 -0.39 44 44
RAS family/GDP -0.018 0.043 -10000 0 -10000 0 0
Rac1/GTP 0 0.058 -10000 0 -0.34 5 5
Ephrin B/EPHB1/Src/Paxillin 0.011 0.06 -10000 0 -0.28 6 6
Effects of Botulinum toxin

Figure S63.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S63.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
STX1A 0.006 0.004 -10000 0 -10000 0 0
UniProt:P19321 0 0 -10000 0 -10000 0 0
RIMS1/UNC13B 0.032 0.022 -10000 0 -10000 0 0
STXBP1 0.027 0.007 -10000 0 -10000 0 0
ACh/CHRNA1 -0.004 0.041 -10000 0 -10000 0 0
RAB3GAP2/RIMS1/UNC13B 0.045 0.026 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
UniProt:P30996 0 0 -10000 0 -10000 0 0
UniProt:Q60393 0 0 -10000 0 -10000 0 0
CST086 0 0 -10000 0 -10000 0 0
RIMS1 0.004 0.029 -10000 0 -10000 0 0
mol:ACh 0.018 0.045 0.093 42 -0.14 1 43
RAB3GAP2 0.027 0.006 -10000 0 -10000 0 0
STX1A/SNAP25/VAMP2 0.029 0.039 -10000 0 -10000 0 0
UniProt:P10844 0 0 -10000 0 -10000 0 0
muscle contraction -0.004 0.041 -10000 0 -10000 0 0
UNC13B 0.027 0.006 -10000 0 -10000 0 0
CHRNA1 -0.043 0.043 -10000 0 -10000 0 0
UniProt:P10845 0 0 -10000 0 -10000 0 0
ACh/Synaptotagmin 1 -0.091 0.2 -10000 0 -0.44 53 53
SNAP25 -0.005 0.025 -10000 0 -0.33 1 1
VAMP2 0.004 0.001 -10000 0 -10000 0 0
SYT1 -0.15 0.3 -10000 0 -0.66 53 53
UniProt:Q00496 0 0 -10000 0 -10000 0 0
STXIA/STXBP1 0.019 0.012 -10000 0 -10000 0 0
STX1A/SNAP25 fragment 1/VAMP2 0.029 0.039 -10000 0 -10000 0 0
Syndecan-4-mediated signaling events

Figure S64.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S64.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.017 0.086 -10000 0 -0.72 2 2
Syndecan-4/Syndesmos -0.14 0.16 -10000 0 -0.54 4 4
positive regulation of JNK cascade -0.17 0.18 -10000 0 -0.59 12 12
Syndecan-4/ADAM12 -0.15 0.16 -10000 0 -0.54 4 4
CCL5 0.016 0.031 -10000 0 -10000 0 0
Rac1/GDP 0.017 0.008 -10000 0 -10000 0 0
DNM2 0.028 0.003 -10000 0 -10000 0 0
ITGA5 0.027 0.005 -10000 0 -10000 0 0
SDCBP 0.027 0.005 -10000 0 -10000 0 0
PLG -0.36 0.31 -10000 0 -0.63 120 120
ADAM12 0.015 0.033 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
NUDT16L1 0.025 0.008 -10000 0 -10000 0 0
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
Syndecan-4/PKC alpha -0.056 0.033 -10000 0 -10000 0 0
Syndecan-4/Laminin alpha1 -0.15 0.18 -10000 0 -0.58 9 9
Syndecan-4/CXCL12/CXCR4 -0.18 0.19 -10000 0 -0.63 12 12
Syndecan-4/Laminin alpha3 -0.15 0.16 -10000 0 -0.54 4 4
MDK 0.004 0.042 -10000 0 -10000 0 0
Syndecan-4/FZD7 -0.16 0.17 -10000 0 -0.56 7 7
Syndecan-4/Midkine -0.15 0.16 -10000 0 -0.54 4 4
FZD7 0.005 0.12 -10000 0 -0.66 7 7
Syndecan-4/FGFR1/FGF -0.13 0.16 -10000 0 -0.51 4 4
THBS1 0.016 0.085 -10000 0 -0.58 4 4
integrin-mediated signaling pathway -0.14 0.16 -10000 0 -0.51 5 5
positive regulation of MAPKKK cascade -0.17 0.18 -10000 0 -0.59 12 12
Syndecan-4/TACI -0.15 0.16 -10000 0 -0.54 4 4
CXCR4 0.022 0.024 -10000 0 -10000 0 0
cell adhesion 0.027 0.039 0.2 7 -10000 0 7
Syndecan-4/Dynamin -0.14 0.16 -10000 0 -0.54 4 4
Syndecan-4/TSP1 -0.15 0.17 -10000 0 -0.56 6 6
Syndecan-4/GIPC -0.14 0.16 -10000 0 -0.54 4 4
Syndecan-4/RANTES -0.15 0.16 -10000 0 -0.54 4 4
ITGB1 0.027 0.005 -10000 0 -10000 0 0
LAMA1 0.003 0.11 -10000 0 -0.66 5 5
LAMA3 -0.002 0.044 -10000 0 -10000 0 0
RAC1 0.022 0.011 -10000 0 -10000 0 0
PRKCA 0.1 0.22 0.84 17 -10000 0 17
Syndecan-4/alpha-Actinin -0.14 0.16 -10000 0 -0.54 4 4
TFPI 0.023 0.048 -10000 0 -0.66 1 1
F2 0.019 0.031 -10000 0 -10000 0 0
alpha5/beta1 Integrin 0.039 0.01 -10000 0 -10000 0 0
positive regulation of cell adhesion -0.16 0.17 -10000 0 -0.57 9 9
ACTN1 0.026 0.007 -10000 0 -10000 0 0
TNC 0.012 0.071 -10000 0 -0.66 2 2
Syndecan-4/CXCL12 -0.18 0.19 -10000 0 -0.63 13 13
FGF6 -0.016 0.011 -10000 0 -10000 0 0
RHOA 0.027 0.006 -10000 0 -10000 0 0
CXCL12 -0.05 0.22 -10000 0 -0.66 24 24
TNFRSF13B 0.007 0.028 -10000 0 -10000 0 0
FGF2 0.027 0.007 -10000 0 -10000 0 0
FGFR1 0.027 0.006 -10000 0 -10000 0 0
Syndecan-4/PI-4-5-P2 -0.15 0.15 -10000 0 -0.51 5 5
mol:GDP 0 0 -10000 0 -10000 0 0
FN1 0.022 0.031 -10000 0 -10000 0 0
cell migration -0.02 0.01 -10000 0 -10000 0 0
PRKCD 0.029 0.02 -10000 0 -10000 0 0
vasculogenesis -0.15 0.16 -10000 0 -0.54 6 6
SDC4 -0.16 0.16 -10000 0 -0.54 5 5
Syndecan-4/Tenascin C -0.15 0.16 -10000 0 -0.53 5 5
Syndecan-4/PI-4-5-P2/PKC alpha -0.045 0.026 -10000 0 -10000 0 0
Syndecan-4/Syntenin -0.14 0.16 -10000 0 -0.54 4 4
MMP9 -0.009 0.077 -10000 0 -0.65 2 2
Rac1/GTP 0.027 0.04 0.2 7 -10000 0 7
cytoskeleton organization -0.14 0.15 -10000 0 -0.52 4 4
GIPC1 0.028 0.002 -10000 0 -10000 0 0
Syndecan-4/TFPI -0.14 0.16 -10000 0 -0.58 4 4
Syndecan-1-mediated signaling events

Figure S65.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S65.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 0.027 0.01 -10000 0 -10000 0 0
CCL5 0.016 0.031 -10000 0 -10000 0 0
SDCBP 0.027 0.005 -10000 0 -10000 0 0
FGFR/FGF2/Syndecan-1 -0.026 0.12 0.25 2 -0.39 12 14
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
RP11-540L11.1 0 0 -10000 0 -10000 0 0
Syndecan-1/Laminin-5 -0.023 0.12 -10000 0 -0.53 5 5
Syndecan-1/Syntenin -0.019 0.12 -10000 0 -0.69 3 3
MAPK3 -0.02 0.11 -10000 0 -0.63 3 3
HGF/MET 0.007 0.1 -10000 0 -0.47 9 9
TGFB1/TGF beta receptor Type II 0.027 0.01 -10000 0 -10000 0 0
BSG 0.028 0.003 -10000 0 -10000 0 0
keratinocyte migration -0.023 0.12 -10000 0 -0.52 5 5
Syndecan-1/RANTES -0.023 0.12 -10000 0 -0.53 5 5
Syndecan-1/CD147 -0.001 0.13 -10000 0 -0.67 3 3
Syndecan-1/Syntenin/PIP2 -0.019 0.12 -10000 0 -0.67 3 3
LAMA5 0.027 0.007 -10000 0 -10000 0 0
positive regulation of cell-cell adhesion -0.018 0.12 -10000 0 -0.65 3 3
MMP7 -0.009 0.1 -10000 0 -0.66 4 4
HGF -0.007 0.14 -10000 0 -0.66 9 9
Syndecan-1/CASK -0.035 0.12 -10000 0 -0.36 13 13
Syndecan-1/HGF/MET -0.024 0.15 -10000 0 -0.52 9 9
regulation of cell adhesion -0.028 0.1 -10000 0 -0.61 3 3
HPSE 0 0.13 -10000 0 -0.66 8 8
positive regulation of cell migration -0.026 0.12 0.25 2 -0.39 12 14
SDC1 -0.027 0.12 -10000 0 -0.4 12 12
Syndecan-1/Collagen -0.026 0.12 0.25 2 -0.39 12 14
PPIB 0.028 0.004 -10000 0 -10000 0 0
MET 0.017 0.024 -10000 0 -10000 0 0
PRKACA 0.028 0.002 -10000 0 -10000 0 0
MMP9 -0.013 0.078 -10000 0 -0.66 2 2
MAPK1 -0.02 0.11 -10000 0 -0.63 3 3
homophilic cell adhesion -0.029 0.12 0.25 2 -0.39 12 14
MMP1 -0.017 0.15 -10000 0 -0.66 11 11
Lissencephaly gene (LIS1) in neuronal migration and development

Figure S66.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S66.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
DYNC1H1 0.026 0.008 -10000 0 -10000 0 0
VLDLR 0.026 0.007 -10000 0 -10000 0 0
LRPAP1 0.027 0.005 -10000 0 -10000 0 0
NUDC 0.026 0.008 -10000 0 -10000 0 0
RELN/LRP8 -0.006 0.1 -10000 0 -0.43 10 10
CaM/Ca2+ 0.019 0.005 -10000 0 -10000 0 0
KATNA1 0.027 0.005 -10000 0 -10000 0 0
GO:0030286 0 0 -10000 0 -10000 0 0
ABL1 0.015 0.12 -10000 0 -0.4 10 10
IQGAP1/CaM 0.038 0.011 -10000 0 -10000 0 0
DAB1 -0.002 0.025 -10000 0 -10000 0 0
IQGAP1 0.027 0.004 -10000 0 -10000 0 0
PLA2G7 -0.049 0.041 -10000 0 -10000 0 0
CALM1 0.026 0.007 -10000 0 -10000 0 0
DYNLT1 0.027 0.005 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
LRPAP1/LRP8 0.037 0.016 -10000 0 -10000 0 0
UniProt:Q4QZ09 0 0 -10000 0 -10000 0 0
CLIP1 0.027 0.006 -10000 0 -10000 0 0
CDK5R1 0.026 0.007 -10000 0 -10000 0 0
LIS1/Poliovirus Protein 3A 0.009 0.003 -10000 0 -10000 0 0
CDK5R2 -0.005 0.042 -10000 0 -10000 0 0
mol:PP1 0 0 -10000 0 -10000 0 0
RELN/VLDLR/DAB1 -0.011 0.1 -10000 0 -0.44 10 10
YWHAE 0.026 0.008 -10000 0 -10000 0 0
NDEL1/14-3-3 E 0.033 0.14 0.31 33 -0.36 1 34
MAP1B 0.006 0.003 -10000 0 -10000 0 0
RAC1 0.011 0.007 -10000 0 -10000 0 0
p35/CDK5 -0.014 0.083 -10000 0 -0.36 10 10
RELN -0.035 0.14 -10000 0 -0.66 10 10
PAFAH/LIS1 -0.025 0.027 -10000 0 -10000 0 0
LIS1/CLIP170 0.027 0.011 -10000 0 -10000 0 0
LIS1/NDEL1/Katanin 60/Dynein Light chain/Dynein heavy chain -0.008 0.07 -10000 0 -10000 0 0
RELN/VLDLR/DAB1/LIS1/PAFAH1B2/PAFAH1B3 -0.008 0.087 -10000 0 -0.37 2 2
GO:0005869 0 0 -10000 0 -10000 0 0
NDEL1 0.03 0.15 0.32 33 -0.37 4 37
LIS1/IQGAP1 0.027 0.011 -10000 0 -10000 0 0
RHOA 0.013 0.005 -10000 0 -10000 0 0
PAFAH1B1 0.012 0.004 -10000 0 -10000 0 0
PAFAH1B3 0.027 0.008 -10000 0 -10000 0 0
PAFAH1B2 0.024 0.047 -10000 0 -0.66 1 1
MAP1B/LIS1/Dynein heavy chain 0.025 0.02 -10000 0 -10000 0 0
NDEL1/Katanin 60/Dynein heavy chain 0.041 0.14 0.31 33 -0.36 1 34
LRP8 0.024 0.015 -10000 0 -10000 0 0
NDEL1/Katanin 60 0.032 0.14 0.31 33 -0.37 1 34
P39/CDK5 -0.026 0.083 -10000 0 -0.36 10 10
LIS1/NudC/Dynein intermediate chain/microtubule organizing center 0.025 0.012 -10000 0 -10000 0 0
CDK5 -0.029 0.082 -10000 0 -0.37 10 10
PPP2R5D 0.027 0.007 -10000 0 -10000 0 0
LIS1/CLIP170/Dynein Complex/Dynactin Complex 0.023 0.009 -10000 0 -10000 0 0
CSNK2A1 0.027 0.006 -10000 0 -10000 0 0
RELN/VLDLR/DAB1/LIS1 0.005 0.094 -10000 0 -0.38 10 10
RELN/VLDLR 0.023 0.099 -10000 0 -0.4 10 10
CDC42 0.012 0.006 -10000 0 -10000 0 0
Cellular roles of Anthrax toxin

Figure S67.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S67.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ANTXR1 0.028 0.004 -10000 0 -10000 0 0
ANTXR2 0.027 0.006 -10000 0 -10000 0 0
negative regulation of myeloid dendritic cell antigen processing and presentation -0.001 0 -10000 0 -10000 0 0
monocyte activation -0.014 0.1 -10000 0 -0.34 20 20
MAP2K2 0.009 0.068 -10000 0 -0.56 3 3
MAP2K1 -0.003 0.001 -10000 0 -10000 0 0
MAP2K7 -0.003 0.001 -10000 0 -10000 0 0
MAP2K6 -0.003 0.001 -10000 0 -10000 0 0
CYAA -0.005 0.001 -10000 0 -10000 0 0
MAP2K4 -0.003 0.001 -10000 0 -10000 0 0
IL1B -0.002 0.055 0.2 2 -0.34 4 6
Channel 0.034 0.009 -10000 0 -10000 0 0
NLRP1 -0.003 0.003 -10000 0 -10000 0 0
CALM1 0.026 0.007 -10000 0 -10000 0 0
negative regulation of phagocytosis -0.013 0.097 -10000 0 -0.38 14 14
mol:Ca2+ 0 0 -10000 0 -10000 0 0
regulation of endothelial cell proliferation 0.001 0 -10000 0 -10000 0 0
MAPK3 -0.003 0.001 -10000 0 -10000 0 0
MAPK1 -0.003 0.001 -10000 0 -10000 0 0
PGR -0.14 0.18 -10000 0 -0.36 83 83
PA/Cellular Receptors 0.036 0.009 -10000 0 -10000 0 0
apoptosis -0.001 0 -10000 0 -10000 0 0
LOC728358 0 0 -10000 0 -10000 0 0
Lethal toxin (unfolded) 0.033 0.009 -10000 0 -10000 0 0
macrophage activation -0.005 0.002 -10000 0 -10000 0 0
TNF 0.014 0.07 -10000 0 -0.66 2 2
VCAM1 -0.006 0.09 -10000 0 -0.32 16 16
platelet activation -0.013 0.097 -10000 0 -0.38 14 14
MAPKKK cascade -0.008 0.034 -10000 0 -0.13 13 13
IL18 0.005 0.028 0.16 2 -10000 0 2
negative regulation of macrophage activation -0.001 0 -10000 0 -10000 0 0
LEF -0.001 0 -10000 0 -10000 0 0
CASP1 0.001 0.002 -10000 0 -10000 0 0
mol:cAMP -0.013 0.097 -10000 0 -0.38 14 14
necrosis -0.001 0 -10000 0 -10000 0 0
intracellular pH reduction 0 0 -10000 0 -10000 0 0
PAGA 0 0 -10000 0 -10000 0 0
Edema toxin (unfolded) 0.033 0.009 -10000 0 -10000 0 0
mol:Epigallocatechin-3-gallate (EGCG) 0 0 -10000 0 -10000 0 0
Fc-epsilon receptor I signaling in mast cells

Figure S68.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S68.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PPAP2A 0.027 0.004 -10000 0 -10000 0 0
LAT2 -0.011 0.059 -10000 0 -0.36 2 2
AP1 -0.008 0.15 -10000 0 -0.48 10 10
mol:PIP3 0.047 0.16 0.48 13 -0.45 2 15
IKBKB 0.044 0.13 0.43 13 -0.26 1 14
AKT1 -0.019 0.087 0.33 6 -10000 0 6
IKBKG 0.042 0.12 0.41 13 -0.26 1 14
MS4A2 -0.005 0.058 -10000 0 -0.52 1 1
mol:Sphingosine-1-phosphate 0 0 -10000 0 -10000 0 0
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
MAP3K1 0.011 0.1 0.33 9 -0.39 3 12
mol:Ca2+ 0.045 0.14 0.45 13 -0.34 2 15
LYN 0.028 0.007 -10000 0 -10000 0 0
CBLB -0.008 0.06 -10000 0 -0.36 2 2
SHC1 0.027 0.005 -10000 0 -10000 0 0
RasGAP/p62DOK 0.05 0.023 -10000 0 -0.21 1 1
positive regulation of cell migration 0 0 -10000 0 -10000 0 0
INPP5D 0.024 0.017 -10000 0 -10000 0 0
PLD2 -0.024 0.066 0.34 2 -0.37 4 6
PTPN13 0.019 0.12 0.41 1 -0.92 2 3
PTPN11 0.025 0.013 -10000 0 -10000 0 0
GO:0007205 0 0 -10000 0 -10000 0 0
regulation of mast cell degranulation 0.019 0.12 0.42 11 -0.39 2 13
SYK 0.024 0.049 -10000 0 -0.67 1 1
GRB2 0.026 0.008 -10000 0 -10000 0 0
LAT/PLCgamma1/GRB2/SLP76/GADs 0.008 0.084 -10000 0 -0.47 2 2
LAT -0.009 0.06 -10000 0 -0.36 2 2
PAK2 0.009 0.1 0.34 8 -0.43 3 11
NFATC2 -0.037 0.15 -10000 0 -0.57 14 14
HRAS 0.006 0.096 0.3 6 -0.42 4 10
GAB2 0.028 0.003 -10000 0 -10000 0 0
PLA2G1B -0.002 0.13 -10000 0 -0.84 5 5
Fc epsilon R1 0.003 0.087 -10000 0 -0.45 5 5
Antigen/IgE/Fc epsilon R1 0.005 0.081 -10000 0 -0.41 5 5
mol:GDP -0.001 0.09 -10000 0 -0.48 4 4
JUN 0.026 0.007 -10000 0 -10000 0 0
mol:Ca++ 0 0 -10000 0 -10000 0 0
PIK3R1 0.028 0.004 -10000 0 -10000 0 0
FOS -0.071 0.23 -10000 0 -0.6 33 33
Antigen/IgE/Fc epsilon R1/LYN/SYK 0 0.065 -10000 0 -0.33 3 3
CHUK 0.042 0.12 0.41 13 -0.26 1 14
KLRG1 -0.008 0.055 -10000 0 -0.29 3 3
VAV1 -0.014 0.072 -10000 0 -0.43 3 3
calcium-dependent protein kinase C activity 0 0 -10000 0 -10000 0 0
CBL -0.008 0.06 -10000 0 -0.36 2 2
negative regulation of mast cell degranulation 0.011 0.067 0.23 2 -0.3 2 4
BTK 0.003 0.083 -10000 0 -0.5 3 3
Fc epsilon R1/FcgammaRIIB/SHIP/RasGAP/p62DOK -0.001 0.074 -10000 0 -0.38 5 5
GAB2/PI3K/SHP2 -0.033 0.056 -10000 0 -0.35 5 5
Antigen/IgE/Fc epsilon R1/LYN/SYK/WIP 0.005 0.047 -10000 0 -0.25 5 5
RAF1 0.002 0.14 -10000 0 -0.9 5 5
Fc epsilon R1/FcgammaRIIB/SHIP 0.024 0.1 -10000 0 -0.45 5 5
FCER1G 0.004 0.043 -10000 0 -10000 0 0
FCER1A 0.01 0.11 -10000 0 -0.67 5 5
Antigen/IgE/Fc epsilon R1/Fyn 0.035 0.077 -10000 0 -0.38 5 5
MAPK3 0.001 0.13 -10000 0 -0.82 5 5
MAPK1 -0.01 0.14 -10000 0 -0.89 5 5
NFKB1 0.027 0.006 -10000 0 -10000 0 0
MAPK8 0.011 0.15 -10000 0 -0.64 8 8
DUSP1 0.024 0.047 -10000 0 -0.66 1 1
NF-kappa-B/RelA 0.022 0.048 0.15 1 -10000 0 1
actin cytoskeleton reorganization 0.021 0.12 -10000 0 -0.97 2 2
mol:Glucocorticoid Dexamethasone 0 0 -10000 0 -10000 0 0
PI3K 0.014 0.085 -10000 0 -0.44 3 3
FER -0.007 0.06 -10000 0 -0.36 2 2
RELA 0.028 0.002 -10000 0 -10000 0 0
ITK 0.004 0.029 -10000 0 -0.23 2 2
SOS1 0.027 0.004 -10000 0 -10000 0 0
PLCG1 0.014 0.11 0.33 7 -0.45 4 11
cytokine secretion 0.01 0.029 -10000 0 -10000 0 0
SPHK1 -0.02 0.058 -10000 0 -0.36 2 2
PTK2 0.02 0.13 -10000 0 -1.1 2 2
NTAL/PLCgamma1/GRB2/SLP76/GADs 0.003 0.083 -10000 0 -0.47 2 2
EDG1 0 0 -10000 0 -10000 0 0
mol:DAG 0.04 0.14 0.45 12 -0.44 2 14
MAP2K2 -0.002 0.13 -10000 0 -0.84 5 5
MAP2K1 -0.003 0.13 -10000 0 -0.84 5 5
MAP2K7 0.028 0.002 -10000 0 -10000 0 0
KLRG1/SHP2 0.005 0.059 -10000 0 -0.27 2 2
MAP2K4 0.006 0.16 -10000 0 -0.78 8 8
Fc epsilon R1/FcgammaRIIB 0.017 0.1 -10000 0 -0.48 5 5
mol:Choline -0.023 0.065 0.34 2 -0.36 4 6
SHC/Grb2/SOS1 0.042 0.072 -10000 0 -0.33 1 1
FYN 0.027 0.005 -10000 0 -10000 0 0
DOK1 0.027 0.008 -10000 0 -10000 0 0
PXN 0.027 0.13 0.38 7 -0.93 2 9
HCLS1 -0.008 0.061 -10000 0 -0.36 2 2
PRKCB 0.047 0.14 0.46 13 -0.33 2 15
FCGR2B -0.004 0.063 -10000 0 -0.66 1 1
IGHE 0 0.006 -10000 0 -10000 0 0
KLRG1/SHIP 0.011 0.068 0.24 2 -0.3 2 4
LCP2 0.025 0.015 -10000 0 -10000 0 0
PLA2G4A -0.01 0.073 -10000 0 -0.38 5 5
RASA1 0.027 0.005 -10000 0 -10000 0 0
mol:Phosphatidic acid -0.023 0.065 0.34 2 -0.36 4 6
IKK complex 0.04 0.12 0.4 13 -10000 0 13
WIPF1 0.027 0.004 -10000 0 -10000 0 0
Ephrin B reverse signaling

Figure S69.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S69.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EFNB2 0.027 0.006 -10000 0 -10000 0 0
EPHB2 0.024 0.016 -10000 0 -10000 0 0
EFNB1 -0.004 0.028 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
Rac1/GDP 0.036 0.057 -10000 0 -0.37 2 2
Ephrin B2/EPHB1-2 0.037 0.057 -10000 0 -0.39 3 3
neuron projection morphogenesis 0.014 0.051 -10000 0 -0.35 2 2
Ephrin B1/EPHB1-2/Tiam1 0.022 0.065 -10000 0 -0.39 3 3
DNM1 -0.002 0.045 -10000 0 -10000 0 0
cell-cell signaling 0 0.004 -10000 0 -10000 0 0
MAP2K4 -0.004 0.09 -10000 0 -0.38 9 9
YES1 -0.014 0.14 -10000 0 -0.62 10 10
Ephrin B1/EPHB1-2/NCK2 0.025 0.066 -10000 0 -0.39 3 3
PI3K 0.024 0.093 -10000 0 -0.39 10 10
mol:GDP 0.021 0.064 -10000 0 -0.39 3 3
ITGA2B 0.018 0.026 -10000 0 -10000 0 0
endothelial cell proliferation 0.029 0.016 -10000 0 -10000 0 0
FYN -0.011 0.14 -10000 0 -0.62 10 10
MAP3K7 -0.008 0.076 -10000 0 -0.42 7 7
FGR -0.009 0.13 -10000 0 -0.62 9 9
TIAM1 0.026 0.008 -10000 0 -10000 0 0
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
RGS3 0.027 0.007 -10000 0 -10000 0 0
cell adhesion -0.003 0.11 -10000 0 -0.38 14 14
LYN -0.011 0.14 -10000 0 -0.62 10 10
Ephrin B1/EPHB1-2/Src Family Kinases -0.015 0.12 -10000 0 -0.55 10 10
Ephrin B1/EPHB1-2 -0.008 0.088 -10000 0 -0.45 8 8
SRC -0.01 0.13 -10000 0 -0.6 10 10
ITGB3 -0.002 0.13 -10000 0 -0.66 8 8
EPHB1 0.015 0.082 -10000 0 -0.66 3 3
EPHB4 0.023 0.011 -10000 0 -10000 0 0
RAC1 0.022 0.011 -10000 0 -10000 0 0
Ephrin B2/EPHB4 0.029 0.016 -10000 0 -10000 0 0
alphaIIb/beta3 Integrin 0.01 0.1 -10000 0 -0.5 8 8
BLK -0.01 0.13 -10000 0 -0.61 10 10
HCK -0.01 0.13 -10000 0 -0.59 10 10
regulation of stress fiber formation -0.024 0.065 0.39 3 -10000 0 3
MAPK8 -0.009 0.1 0.28 2 -0.39 11 13
Ephrin B1/EPHB1-2/RGS3 0.025 0.066 -10000 0 -0.39 3 3
endothelial cell migration 0.025 0.099 0.43 1 -0.32 7 8
NCK2 0.028 0.003 -10000 0 -10000 0 0
PTPN13 0.027 0.009 -10000 0 -10000 0 0
regulation of focal adhesion formation -0.024 0.065 0.39 3 -10000 0 3
chemotaxis -0.024 0.065 0.39 3 -10000 0 3
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
Rac1/GTP 0.029 0.052 -10000 0 -0.36 2 2
angiogenesis -0.012 0.096 -10000 0 -0.44 10 10
LCK -0.008 0.13 -10000 0 -0.62 9 9
Signaling mediated by p38-gamma and p38-delta

Figure S70.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S70.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EEF2K -0.008 0.005 -10000 0 -10000 0 0
SNTA1 0.017 0.081 -10000 0 -0.66 3 3
response to hypoxia 0 0 -10000 0 -10000 0 0
STMN1 -0.01 0.028 -10000 0 -0.41 1 1
MAPK12 0.015 0.053 0.21 14 -10000 0 14
CCND1 0.014 0.049 -10000 0 -0.39 2 2
p38 gamma/SNTA1 0.024 0.064 -10000 0 -0.37 3 3
MAP2K3 0.026 0.008 -10000 0 -10000 0 0
PKN1 0.028 0.002 -10000 0 -10000 0 0
G2/M transition checkpoint 0.015 0.053 0.21 14 -10000 0 14
MAP2K6 0.007 0.002 -10000 0 -10000 0 0
MAPT 0.005 0.11 0.29 14 -0.36 11 25
MAPK13 0.01 0.034 -10000 0 -0.48 1 1
hyperosmotic response 0 0 -10000 0 -10000 0 0
ZAK 0.015 0.002 -10000 0 -10000 0 0
Regulation of p38-alpha and p38-beta

Figure S71.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S71.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
RIP1/MEKK3 0.033 0.013 -10000 0 -10000 0 0
response to insulin stimulus 0 0 -10000 0 -10000 0 0
RIPK1 0.027 0.006 -10000 0 -10000 0 0
response to stress 0 0 -10000 0 -10000 0 0
MAP2K6 0.026 0.008 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
MAP2K4 0.026 0.008 -10000 0 -10000 0 0
RAC1-CDC42/GTP/PAK family 0.013 0.009 -10000 0 -10000 0 0
response to UV 0 0 -10000 0 -10000 0 0
YES1 0.026 0.008 -10000 0 -10000 0 0
interleukin-1 receptor activity 0 0 -10000 0 -10000 0 0
tumor necrosis factor receptor activity 0 0 -10000 0 -10000 0 0
MAP3K3 0.026 0.008 -10000 0 -10000 0 0
FYN 0.027 0.005 -10000 0 -10000 0 0
MAP3K12 0.027 0.005 -10000 0 -10000 0 0
FGR 0.02 0.05 -10000 0 -0.66 1 1
p38 alpha/TAB1 -0.023 0.072 -10000 0 -0.34 7 7
PRKG1 -0.13 0.28 -10000 0 -0.65 48 48
DUSP8 0.028 0.004 -10000 0 -10000 0 0
PGK/cGMP/p38 alpha -0.042 0.16 -10000 0 -0.32 37 37
apoptosis -0.022 0.069 -10000 0 -0.37 5 5
RAL/GTP 0.03 0.015 -10000 0 -10000 0 0
LYN 0.027 0.005 -10000 0 -10000 0 0
DUSP1 0.024 0.047 -10000 0 -0.66 1 1
PAK1 0.028 0.003 -10000 0 -10000 0 0
SRC 0.026 0.009 -10000 0 -10000 0 0
RAC1/OSM/MEKK3/MKK3 0.052 0.033 -10000 0 -10000 0 0
TRAF6 0.028 0.004 -10000 0 -10000 0 0
RAC1 0.022 0.011 -10000 0 -10000 0 0
epidermal growth factor receptor activity 0 0 -10000 0 -10000 0 0
mol:LPS 0 0 -10000 0 -10000 0 0
mol:cGMP 0 0 -10000 0 -10000 0 0
CCM2 0.023 0.011 -10000 0 -10000 0 0
RAC1-CDC42/GTP 0.027 0.017 -10000 0 -10000 0 0
MAPK11 0.052 0.15 0.4 13 -0.46 5 18
BLK 0.017 0.025 -10000 0 -10000 0 0
HCK 0.012 0.056 -10000 0 -0.66 1 1
MAP2K3 0.026 0.008 -10000 0 -10000 0 0
DUSP16 0.027 0.006 -10000 0 -10000 0 0
DUSP10 0.02 0.026 -10000 0 -10000 0 0
TRAF6/MEKK3 0.033 0.011 -10000 0 -10000 0 0
MAP3K7IP1 0 0 -10000 0 -10000 0 0
MAPK14 0.048 0.14 0.35 14 -0.46 4 18
positive regulation of innate immune response 0.061 0.17 0.42 16 -0.46 6 22
LCK 0.024 0.017 -10000 0 -10000 0 0
p38alpha-beta/MKP7 0.053 0.14 0.37 8 -0.55 3 11
p38alpha-beta/MKP5 0.067 0.16 0.42 14 -0.49 4 18
PGK/cGMP -0.096 0.21 -10000 0 -0.49 48 48
PAK2 0.027 0.005 -10000 0 -10000 0 0
p38alpha-beta/MKP1 0.061 0.15 0.4 11 -0.5 4 15
CDC42 0.026 0.008 -10000 0 -10000 0 0
RALB 0.028 0.003 -10000 0 -10000 0 0
RALA 0.022 0.011 -10000 0 -10000 0 0
PAK3 0.019 0.019 -10000 0 -10000 0 0
Arf6 trafficking events

Figure S72.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S72.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SLC2A4 0.02 0.054 -10000 0 -0.5 2 2
CLTC 0.01 0.1 -10000 0 -0.38 12 12
calcium ion-dependent exocytosis 0.019 0.053 -10000 0 -0.26 3 3
Dynamin 2/GTP 0.024 0.012 -10000 0 -10000 0 0
EXOC4 0.023 0.011 -10000 0 -10000 0 0
CD59 0.006 0.082 -10000 0 -0.31 12 12
CPE 0.012 0.009 -10000 0 -10000 0 0
CTNNB1 0.027 0.006 -10000 0 -10000 0 0
membrane fusion 0.025 0.039 -10000 0 -10000 0 0
CTNND1 0.024 0.047 -10000 0 -10000 0 0
DNM2 0.028 0.003 -10000 0 -10000 0 0
mol:PI-4-5-P2 0.012 0.065 -10000 0 -0.3 4 4
TSHR 0.009 0.011 -10000 0 -10000 0 0
INS 0.007 0.068 -10000 0 -0.45 4 4
BIN1 0.021 0.066 -10000 0 -0.66 2 2
mol:Choline 0.025 0.039 -10000 0 -10000 0 0
growth hormone secretagogue receptor activity 0 0 -10000 0 -10000 0 0
mol:GDP 0.012 0.007 -10000 0 -10000 0 0
membrane depolarization 0 0 -10000 0 -10000 0 0
ARF6 0.026 0.007 -10000 0 -10000 0 0
mol:Ca2+ 0.023 0.012 -10000 0 -10000 0 0
JUP 0.004 0.083 -10000 0 -0.31 12 12
ASAP2/amphiphysin II 0.043 0.054 -10000 0 -0.39 3 3
ARF6/GTP 0.019 0.005 -10000 0 -10000 0 0
CDH1 -0.011 0.12 -10000 0 -0.41 12 12
clathrin-independent pinocytosis 0.019 0.005 -10000 0 -10000 0 0
MAPK8IP3 0.024 0.016 -10000 0 -10000 0 0
positive regulation of endocytosis 0.019 0.005 -10000 0 -10000 0 0
EXOC2 0.027 0.006 -10000 0 -10000 0 0
substrate adhesion-dependent cell spreading 0.011 0.05 -10000 0 -0.31 3 3
insulin receptor binding 0 0 -10000 0 -10000 0 0
SPAG9 0.026 0.008 -10000 0 -10000 0 0
regulation of calcium-dependent cell-cell adhesion -0.016 0.12 0.5 5 -10000 0 5
positive regulation of phagocytosis 0.013 0.005 -10000 0 -10000 0 0
ARF6/GTP/JIP3 0.031 0.016 -10000 0 -10000 0 0
ACAP1 0.025 0.049 -10000 0 -0.22 3 3
mol:GTP 0 0 -10000 0 -10000 0 0
CHRM2 -0.008 0.08 -10000 0 -0.32 12 12
clathrin heavy chain/ACAP1 0.017 0.089 0.26 1 -0.38 4 5
JIP4/KLC1 0.046 0.02 -10000 0 -10000 0 0
EXOC1 0.027 0.006 -10000 0 -10000 0 0
exocyst 0.011 0.05 -10000 0 -0.31 3 3
RALA/GTP 0.017 0.008 -10000 0 -10000 0 0
ARF6/GTP/ARF6/GTP/JIP4/Dynactin Complex 0.033 0.014 -10000 0 -10000 0 0
receptor recycling 0.019 0.005 -10000 0 -10000 0 0
CTNNA1 0.021 0.043 -10000 0 -10000 0 0
NME1 0.012 0.007 -10000 0 -10000 0 0
clathrin coat assembly 0.018 0.11 0.25 3 -0.37 12 15
IL2RA 0.003 0.086 -10000 0 -0.32 12 12
VAMP3 0.013 0.005 -10000 0 -10000 0 0
GLUT4/clathrin heavy chain/ACAP1 0.021 0.084 -10000 0 -0.36 4 4
EXOC6 0.028 0.003 -10000 0 -10000 0 0
PLD1 0.009 0.013 -10000 0 -10000 0 0
PLD2 0.009 0.012 -10000 0 -10000 0 0
EXOC5 0.026 0.007 -10000 0 -10000 0 0
PIP5K1C 0.012 0.065 -10000 0 -0.3 4 4
SDC1 0.005 0.085 -10000 0 -0.31 12 12
ARF6/GDP 0.022 0.011 -10000 0 -10000 0 0
EXOC7 0.026 0.008 -10000 0 -10000 0 0
E-cadherin/beta catenin 0.018 0.12 -10000 0 -0.52 5 5
mol:Phosphatidic acid 0.025 0.039 -10000 0 -10000 0 0
endocytosis -0.041 0.054 0.39 3 -10000 0 3
SCAMP2 0.027 0.004 -10000 0 -10000 0 0
ADRB2 0.02 0.12 0.33 6 -0.36 11 17
EXOC3 0.027 0.005 -10000 0 -10000 0 0
ASAP2 0.024 0.047 -10000 0 -0.66 1 1
Dynamin 2/GDP 0.027 0.013 -10000 0 -10000 0 0
KLC1 0.026 0.008 -10000 0 -10000 0 0
AVPR2 -0.26 0.18 0.28 1 -0.36 124 125
RALA 0.022 0.011 -10000 0 -10000 0 0
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.014 0.12 0.33 1 -0.49 5 6
BCR signaling pathway

Figure S73.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S73.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
JUN 0.008 0.12 0.39 2 -0.45 7 9
IKBKB 0.027 0.092 0.29 5 -0.32 1 6
AKT1 0.013 0.098 0.34 11 -10000 0 11
IKBKG 0.031 0.081 0.29 4 -0.27 2 6
CALM1 -0.004 0.094 0.36 1 -0.41 5 6
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
MAP3K1 0.029 0.13 0.4 4 -0.47 5 9
MAP3K7 0.027 0.005 -10000 0 -10000 0 0
mol:Ca2+ -0.005 0.097 -10000 0 -0.4 6 6
DOK1 0.027 0.008 -10000 0 -10000 0 0
AP-1 -0.015 0.097 0.4 1 -0.26 9 10
LYN 0.027 0.005 -10000 0 -10000 0 0
BLNK -0.001 0.14 -10000 0 -0.66 9 9
SHC1 0.027 0.005 -10000 0 -10000 0 0
BCR complex 0.015 0.078 -10000 0 -0.5 4 4
CD22 -0.005 0.072 -10000 0 -0.47 4 4
CAMK2G -0.007 0.091 0.35 1 -0.4 4 5
CSNK2A1 0.027 0.006 -10000 0 -10000 0 0
INPP5D 0.024 0.017 -10000 0 -10000 0 0
SHC/GRB2/SOS1 0.004 0.086 -10000 0 -0.38 8 8
GO:0007205 -0.005 0.099 -10000 0 -0.41 6 6
SYK 0.023 0.047 -10000 0 -0.66 1 1
ELK1 -0.006 0.096 0.26 1 -0.39 6 7
NFATC1 -0.002 0.091 0.37 3 -0.38 3 6
B-cell antigen/BCR complex 0.015 0.078 -10000 0 -0.5 4 4
PAG1/CSK 0.04 0.008 -10000 0 -10000 0 0
NFKBIB 0.024 0.052 0.15 7 -0.13 10 17
HRAS 0 0.09 0.28 1 -0.41 4 5
NFKBIA 0.025 0.051 0.15 7 -0.12 9 16
NF-kappa-B/RelA/I kappa B beta 0.029 0.045 0.17 5 -10000 0 5
RasGAP/Csk 0.049 0.074 -10000 0 -0.38 4 4
mol:GDP -0.004 0.097 -10000 0 -0.39 7 7
PTEN 0.028 0.003 -10000 0 -10000 0 0
CD79B 0.019 0.067 -10000 0 -0.66 2 2
NF-kappa-B/RelA/I kappa B alpha 0.03 0.045 0.17 5 -10000 0 5
GRB2 0.026 0.008 -10000 0 -10000 0 0
PI3K/BCAP/CD19 0.015 0.11 0.46 2 -0.51 2 4
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
mol:IP3 -0.006 0.097 -10000 0 -0.4 7 7
CSK 0.027 0.004 -10000 0 -10000 0 0
FOS -0.051 0.15 0.24 1 -0.4 24 25
CHUK 0.029 0.085 0.29 4 -0.29 1 5
IBTK 0.027 0.005 -10000 0 -10000 0 0
CARD11/BCL10/MALT1/TAK1 0.039 0.11 0.3 3 -0.4 3 6
PTPN6 -0.01 0.068 -10000 0 -0.49 3 3
RELA 0.028 0.002 -10000 0 -10000 0 0
BCL2A1 0.019 0.031 0.15 2 -10000 0 2
VAV2 0.002 0.086 -10000 0 -0.5 3 3
ubiquitin-dependent protein catabolic process 0.027 0.052 0.15 7 -0.13 8 15
BTK 0.01 0.09 -10000 0 -0.9 2 2
CD19 -0.004 0.07 -10000 0 -0.47 4 4
MAP4K1 0.016 0.033 -10000 0 -10000 0 0
CD72 0.018 0.028 -10000 0 -10000 0 0
PAG1 0.027 0.004 -10000 0 -10000 0 0
MAPK14 0.029 0.11 0.38 4 -0.4 5 9
SH3BP5 0.007 0.11 -10000 0 -0.66 6 6
PIK3AP1 -0.005 0.1 -10000 0 -0.42 7 7
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 -0.018 0.13 -10000 0 -0.48 13 13
RAF1 0.002 0.087 0.27 1 -0.43 3 4
RasGAP/p62DOK/SHIP 0.046 0.074 -10000 0 -0.37 4 4
CD79A 0.007 0.073 -10000 0 -0.66 2 2
re-entry into mitotic cell cycle -0.014 0.095 0.39 1 -0.26 10 11
RASA1 0.027 0.005 -10000 0 -10000 0 0
MAPK3 0.013 0.094 0.32 7 -0.34 2 9
MAPK1 0.001 0.076 0.24 1 -0.36 3 4
CD72/SHP1 0.013 0.085 0.34 2 -0.47 3 5
NFKB1 0.027 0.006 -10000 0 -10000 0 0
MAPK8 0.023 0.12 0.38 4 -0.41 6 10
actin cytoskeleton organization 0.031 0.11 0.33 4 -0.43 3 7
NF-kappa-B/RelA 0.058 0.087 0.27 7 -10000 0 7
Calcineurin 0.025 0.093 0.33 1 -0.38 4 5
PI3K 0 0.065 -10000 0 -0.38 3 3
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 -0.001 0.1 0.25 4 -0.43 7 11
SOS1 0.027 0.004 -10000 0 -10000 0 0
Bam32/HPK1 0.004 0.17 -10000 0 -0.65 12 12
DAPP1 -0.016 0.18 -10000 0 -0.72 12 12
cytokine secretion -0.001 0.088 0.36 3 -0.35 3 6
mol:DAG -0.006 0.097 -10000 0 -0.4 7 7
PLCG2 -0.007 0.14 -10000 0 -0.66 10 10
MAP2K1 0.001 0.083 0.25 1 -0.4 3 4
B-cell antigen/BCR complex/FcgammaRIIB 0.001 0.082 -10000 0 -0.43 5 5
mol:PI-3-4-5-P3 -0.017 0.054 0.24 1 -0.31 1 2
ETS1 -0.007 0.084 0.33 1 -0.37 4 5
B-cell antigen/BCR complex/LYN/SYK/BLNK 0.042 0.11 -10000 0 -0.42 9 9
B-cell antigen/BCR complex/LYN 0.007 0.076 -10000 0 -0.48 4 4
MALT1 0.026 0.008 -10000 0 -10000 0 0
TRAF6 0.028 0.004 -10000 0 -10000 0 0
RAC1 0.03 0.11 0.29 3 -0.46 3 6
B-cell antigen/BCR complex/LYN/SYK 0.035 0.087 -10000 0 -0.5 3 3
CARD11 0.021 0.12 0.34 3 -0.46 3 6
FCGR2B -0.004 0.063 -10000 0 -0.66 1 1
PPP3CA 0.027 0.006 -10000 0 -10000 0 0
BCL10 0.026 0.007 -10000 0 -10000 0 0
IKK complex 0.023 0.053 0.18 11 -0.12 1 12
PTPRC 0.023 0.048 -10000 0 -0.66 1 1
PDPK1 -0.014 0.041 0.2 2 -10000 0 2
PPP3CB 0.028 0.003 -10000 0 -10000 0 0
PPP3CC 0.027 0.006 -10000 0 -10000 0 0
POU2F2 0.022 0.031 0.15 2 -10000 0 2
Signaling events mediated by PRL

Figure S74.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S74.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CCNE1 0.02 0.027 -10000 0 -10000 0 0
mol:Halofuginone 0.003 0.001 -10000 0 -10000 0 0
ITGA1 0.021 0.066 -10000 0 -0.66 2 2
CDKN1A -0.013 0.11 -10000 0 -0.41 13 13
PRL-3/alpha Tubulin 0.04 0.009 -10000 0 -10000 0 0
mol:Ca2+ -0.041 0.098 -10000 0 -0.51 9 9
AGT -0.004 0.14 -10000 0 -0.63 10 10
CCNA2 -0.033 0.092 -10000 0 -10000 0 0
TUBA1B 0.027 0.005 -10000 0 -10000 0 0
EGR1 -0.025 0.14 -10000 0 -0.49 17 17
CDK2/Cyclin E1 0.007 0.13 -10000 0 -0.35 20 20
MAPK3 0.012 0.004 -10000 0 -10000 0 0
PRL-2 /Rab GGTase beta 0.039 0.011 -10000 0 -10000 0 0
MAPK1 0.012 0.004 -10000 0 -10000 0 0
PTP4A1 -0.024 0.099 -10000 0 -0.38 15 15
PTP4A3 0.027 0.004 -10000 0 -10000 0 0
PTP4A2 0.026 0.007 -10000 0 -10000 0 0
ITGB1 0.013 0.003 -10000 0 -10000 0 0
SRC 0.026 0.009 -10000 0 -10000 0 0
RAC1 0.007 0.041 -10000 0 -10000 0 0
Rab GGTase beta/Rab GGTase alpha 0.038 0.013 -10000 0 -10000 0 0
PRL-1/ATF-5 -0.001 0.11 -10000 0 -10000 0 0
RABGGTA 0.026 0.008 -10000 0 -10000 0 0
BCAR1 -0.019 0.006 -10000 0 -10000 0 0
RHOC -0.001 0.086 -10000 0 -0.39 7 7
RHOA 0.001 0.075 -10000 0 -0.35 6 6
cell motility 0 0.11 0.29 3 -0.36 10 13
PRL-1/alpha Tubulin -0.002 0.1 -10000 0 -10000 0 0
PRL-3/alpha1 Integrin 0.035 0.053 -10000 0 -0.5 2 2
ROCK1 0.001 0.089 0.28 1 -0.35 7 8
RABGGTB 0.027 0.006 -10000 0 -10000 0 0
CDK2 0.027 0.005 -10000 0 -10000 0 0
mitosis -0.026 0.1 -10000 0 -0.38 15 15
ATF5 0.028 0.003 -10000 0 -10000 0 0
Class IB PI3K non-lipid kinase events

Figure S75.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S75.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
cAMP biosynthetic process -0.013 0.094 0.66 4 -10000 0 4
PI3K Class IB/PDE3B 0.013 0.094 -10000 0 -0.66 4 4
PDE3B 0.013 0.094 -10000 0 -0.66 4 4
Ras signaling in the CD4+ TCR pathway

Figure S76.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S76.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ERK1-2/ELK1 -0.006 0.18 -10000 0 -0.52 13 13
MAP3K8 0.024 0.012 -10000 0 -10000 0 0
FOS 0.007 0.13 0.27 2 -0.46 9 11
PRKCA 0.02 0.018 -10000 0 -10000 0 0
PTPN7 0.016 0.053 -10000 0 -0.67 1 1
HRAS 0.026 0.008 -10000 0 -10000 0 0
PRKCB 0.019 0.021 -10000 0 -10000 0 0
NRAS 0.025 0.01 -10000 0 -10000 0 0
RAS family/GTP 0.042 0.028 -10000 0 -10000 0 0
MAPK3 0.019 0.09 -10000 0 -0.42 7 7
MAP2K1 0.03 0.044 -10000 0 -10000 0 0
ELK1 0.018 0.025 -10000 0 -10000 0 0
BRAF 0.012 0.018 -10000 0 -10000 0 0
mol:GTP -0.001 0.003 -10000 0 -0.007 33 33
MAPK1 -0.011 0.15 -10000 0 -0.48 13 13
RAF1 0.015 0.018 -10000 0 -10000 0 0
KRAS 0.026 0.006 -10000 0 -10000 0 0
ErbB2/ErbB3 signaling events

Figure S77.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S77.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
USP8 -0.005 0.009 -10000 0 -10000 0 0
RAS family/GTP 0.035 0.068 -10000 0 -0.3 1 1
NFATC4 -0.008 0.077 0.31 6 -0.28 4 10
ERBB2IP 0.027 0.007 -10000 0 -10000 0 0
HSP90 (dimer) 0.026 0.008 -10000 0 -10000 0 0
mammary gland morphogenesis 0.009 0.065 -10000 0 -0.35 6 6
JUN 0.015 0.06 0.2 3 -10000 0 3
HRAS 0.027 0.003 -10000 0 -10000 0 0
DOCK7 -0.017 0.068 0.28 1 -0.34 6 7
ErbB2/ErbB3/neuregulin 1 beta/SHC 0.03 0.075 -10000 0 -0.39 6 6
AKT1 0.006 0.006 -10000 0 -10000 0 0
BAD -0.005 0.006 -10000 0 -10000 0 0
MAPK10 0.009 0.062 0.19 6 -10000 0 6
mol:GTP -0.001 0.001 -10000 0 -10000 0 0
ErbB2/ErbB3/neuregulin 1 beta 0.01 0.07 -10000 0 -0.37 6 6
RAF1 0.009 0.072 0.35 2 -10000 0 2
ErbB2/ErbB3/neuregulin 2 0.023 0.062 -10000 0 -0.41 4 4
STAT3 0.032 0.015 -10000 0 -10000 0 0
cell migration 0.024 0.093 0.32 11 -10000 0 11
mol:PI-3-4-5-P3 0 0.002 -10000 0 -10000 0 0
cell proliferation -0.033 0.16 0.37 1 -0.54 6 7
FOS -0.061 0.2 0.3 2 -0.49 34 36
NRAS 0.026 0.006 -10000 0 -10000 0 0
mol:Ca2+ 0.009 0.065 -10000 0 -0.35 6 6
MAPK3 -0.003 0.1 0.34 2 -10000 0 2
MAPK1 -0.036 0.18 0.35 2 -0.63 10 12
JAK2 -0.016 0.069 0.28 1 -0.33 6 7
NF2 0.007 0.044 -10000 0 -0.62 1 1
ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 0.015 0.066 -10000 0 -0.3 6 6
NRG1 0.012 0.094 -10000 0 -0.66 4 4
GRB2/SOS1 0.037 0.012 -10000 0 -10000 0 0
MAPK8 0.011 0.08 0.25 1 -0.31 7 8
MAPK9 0.008 0.06 0.18 5 -10000 0 5
ERBB2 -0.019 0.007 -10000 0 -10000 0 0
ERBB3 0.02 0.067 -10000 0 -0.66 2 2
SHC1 0.027 0.005 -10000 0 -10000 0 0
RAC1 0.022 0.011 -10000 0 -10000 0 0
apoptosis 0.003 0.008 -10000 0 -10000 0 0
STAT3 (dimer) 0.032 0.015 -10000 0 -10000 0 0
RNF41 -0.008 0.006 -10000 0 -10000 0 0
FRAP1 -0.002 0.005 -10000 0 -10000 0 0
RAC1-CDC42/GTP -0.014 0.044 -10000 0 -0.25 6 6
ErbB2/ErbB2/HSP90 (dimer) 0.012 0.015 -10000 0 -10000 0 0
CHRNA1 -0.017 0.11 0.32 2 -0.54 1 3
myelination -0.003 0.09 0.35 8 -0.28 2 10
PPP3CB -0.015 0.066 0.27 1 -0.31 6 7
KRAS 0.026 0.006 -10000 0 -10000 0 0
RAC1-CDC42/GDP 0.03 0.068 0.27 1 -0.28 2 3
NRG2 0.019 0.071 -10000 0 -0.55 3 3
mol:GDP 0.015 0.066 -10000 0 -0.3 6 6
SOS1 0.027 0.004 -10000 0 -10000 0 0
MAP2K2 -0.008 0.072 0.35 2 -10000 0 2
SRC 0.026 0.009 -10000 0 -10000 0 0
mol:cAMP -0.001 0.001 -10000 0 -10000 0 0
PTPN11 -0.016 0.07 0.28 1 -0.34 6 7
MAP2K1 -0.013 0.14 0.36 1 -0.63 4 5
heart morphogenesis 0.009 0.065 -10000 0 -0.35 6 6
RAS family/GDP 0.048 0.071 0.27 1 -10000 0 1
GRB2 0.026 0.008 -10000 0 -10000 0 0
PRKACA 0.012 0.046 -10000 0 -0.65 1 1
CHRNE 0.011 0.019 0.085 6 -10000 0 6
HSP90AA1 0.026 0.008 -10000 0 -10000 0 0
activation of caspase activity -0.006 0.006 -10000 0 -10000 0 0
nervous system development 0.009 0.065 -10000 0 -0.35 6 6
CDC42 0.026 0.008 -10000 0 -10000 0 0
Syndecan-2-mediated signaling events

Figure S78.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S78.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Syndecan-2/Fibronectin 0.024 0.017 -10000 0 -10000 0 0
EPHB2 0.024 0.016 -10000 0 -10000 0 0
Syndecan-2/TACI 0.022 0.016 -10000 0 -10000 0 0
LAMA1 0.003 0.11 -10000 0 -0.66 5 5
Syndecan-2/alpha2 ITGB1 0.05 0.021 -10000 0 -10000 0 0
HRAS 0.028 0.003 -10000 0 -10000 0 0
Syndecan-2/CASK 0.009 0.002 -10000 0 -10000 0 0
ITGA5 0.027 0.005 -10000 0 -10000 0 0
BAX -0.001 0.047 -10000 0 -10000 0 0
EPB41 0.026 0.008 -10000 0 -10000 0 0
positive regulation of cell-cell adhesion 0.026 0.006 -10000 0 -10000 0 0
LAMA3 -0.002 0.044 -10000 0 -10000 0 0
EZR 0.027 0.005 -10000 0 -10000 0 0
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
CAV2 0.022 0.013 -10000 0 -10000 0 0
Syndecan-2/MMP2 0.027 0.011 -10000 0 -10000 0 0
RP11-540L11.1 0 0 -10000 0 -10000 0 0
alpha2 ITGB1 0.04 0.009 -10000 0 -10000 0 0
dendrite morphogenesis 0.026 0.013 -10000 0 -10000 0 0
Syndecan-2/GM-CSF 0.024 0.01 -10000 0 -10000 0 0
determination of left/right symmetry 0.012 0.003 -10000 0 -10000 0 0
Syndecan-2/PKC delta 0.028 0.009 -10000 0 -10000 0 0
GNB2L1 0.027 0.005 -10000 0 -10000 0 0
MAPK3 0.011 0.014 -10000 0 -10000 0 0
MAPK1 0.012 0.018 -10000 0 -10000 0 0
Syndecan-2/RACK1 0.041 0.011 -10000 0 -10000 0 0
NF1 0.026 0.007 -10000 0 -10000 0 0
FGFR/FGF/Syndecan-2 0.012 0.003 -10000 0 -10000 0 0
ITGA2 0.027 0.004 -10000 0 -10000 0 0
MAPK8 0.004 0.053 -10000 0 -0.42 3 3
Syndecan-2/alpha2/beta1 Integrin 0.044 0.064 -10000 0 -0.37 4 4
Syndecan-2/Kininogen -0.24 0.22 -10000 0 -0.42 123 123
ITGB1 0.027 0.005 -10000 0 -10000 0 0
SRC 0.018 0.023 -10000 0 -10000 0 0
Syndecan-2/CASK/Protein 4.1 0.025 0.009 -10000 0 -10000 0 0
extracellular matrix organization 0.028 0.009 -10000 0 -10000 0 0
actin cytoskeleton reorganization 0.024 0.017 -10000 0 -10000 0 0
Syndecan-2/Caveolin-2/Ras 0.035 0.021 -10000 0 -10000 0 0
Syndecan-2/Laminin alpha3 0.01 0.028 -10000 0 -10000 0 0
Syndecan-2/RasGAP 0.053 0.015 -10000 0 -10000 0 0
alpha5/beta1 Integrin 0.039 0.01 -10000 0 -10000 0 0
PRKCD 0.027 0.006 -10000 0 -10000 0 0
Syndecan-2 dimer 0.026 0.013 -10000 0 -10000 0 0
GO:0007205 0.002 0.001 -10000 0 -10000 0 0
DNA mediated transformation 0 0 -10000 0 -10000 0 0
Syndecan-2/RasGAP/Src 0.037 0.019 -10000 0 -10000 0 0
RHOA 0.027 0.006 -10000 0 -10000 0 0
SDCBP 0.027 0.005 -10000 0 -10000 0 0
TNFRSF13B 0.007 0.028 -10000 0 -10000 0 0
RASA1 0.027 0.005 -10000 0 -10000 0 0
alpha2/beta1 Integrin 0.04 0.009 -10000 0 -10000 0 0
Syndecan-2/Synbindin 0.028 0.008 -10000 0 -10000 0 0
TGFB1 0.027 0.01 -10000 0 -10000 0 0
CASP3 0.014 0.014 -10000 0 -10000 0 0
FN1 0.021 0.025 -10000 0 -10000 0 0
Syndecan-2/IL8 0.012 0.04 -10000 0 -0.42 1 1
SDC2 0.012 0.003 -10000 0 -10000 0 0
KNG1 -0.39 0.32 -10000 0 -0.66 123 123
Syndecan-2/Neurofibromin 0.028 0.009 -10000 0 -10000 0 0
TRAPPC4 0.027 0.005 -10000 0 -10000 0 0
CSF2 0.002 0.025 -10000 0 -10000 0 0
Syndecan-2/TGFB1 0.028 0.009 -10000 0 -10000 0 0
Syndecan-2/Syntenin/PI-4-5-P2 0.027 0.006 -10000 0 -10000 0 0
Syndecan-2/Ezrin 0.043 0.013 -10000 0 -10000 0 0
PRKACA 0.015 0.013 0.19 1 -10000 0 1
angiogenesis 0.012 0.04 -10000 0 -0.42 1 1
MMP2 0.025 0.012 -10000 0 -10000 0 0
IL8 0.001 0.062 -10000 0 -0.66 1 1
calcineurin-NFAT signaling pathway 0.022 0.016 -10000 0 -10000 0 0
PLK1 signaling events

Figure S79.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S79.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
regulation of centriole-centriole cohesion -0.004 0.031 0.14 5 -0.13 5 10
BUB1B 0.008 0.037 0.15 5 -0.18 1 6
PLK1 0.01 0.031 0.12 9 -10000 0 9
PLK1S1 0.014 0.027 0.13 8 -10000 0 8
KIF2A 0.009 0.041 0.28 3 -10000 0 3
regulation of mitotic centrosome separation 0.01 0.031 0.12 9 -10000 0 9
GOLGA2 0.027 0.007 -10000 0 -10000 0 0
Hec1/SPC24 0.03 0.04 -10000 0 -10000 0 0
WEE1 0.014 0.06 -10000 0 -0.32 5 5
cytokinesis 0.006 0.058 0.22 5 -0.22 1 6
PP2A-alpha B56 0.054 0.056 -10000 0 -0.5 2 2
AURKA 0.013 0.021 0.12 2 -10000 0 2
PICH/PLK1 0.009 0.026 -10000 0 -10000 0 0
CENPE 0.006 0.034 0.23 2 -10000 0 2
RhoA/GTP 0.02 0.005 -10000 0 -10000 0 0
positive regulation of microtubule depolymerization 0.009 0.04 0.27 3 -10000 0 3
PPP2CA 0.027 0.005 -10000 0 -10000 0 0
FZR1 0.028 0.003 -10000 0 -10000 0 0
TPX2 0.011 0.028 0.12 9 -10000 0 9
PAK1 0.028 0.003 -10000 0 -10000 0 0
SPC24 0.009 0.037 -10000 0 -10000 0 0
FBXW11 0.027 0.005 -10000 0 -10000 0 0
CLSPN -0.005 0.067 -10000 0 -0.24 15 15
GORASP1 0.027 0.006 -10000 0 -10000 0 0
metaphase 0.002 0.005 0.018 19 -10000 0 19
mol:GTP 0 0 -10000 0 -10000 0 0
NLP 0.004 0.017 0.069 9 -10000 0 9
G2 phase of mitotic cell cycle 0 0.003 0.011 7 -10000 0 7
STAG2 0.028 0.002 -10000 0 -10000 0 0
GRASP65/GM130/RAB1/GTP 0.008 0.09 -10000 0 -0.52 6 6
spindle elongation 0.01 0.031 0.12 9 -10000 0 9
ODF2 0.027 0.007 -10000 0 -10000 0 0
BUB1 0.021 0.056 -10000 0 -0.53 2 2
TPT1 0.005 0.045 0.11 2 -0.2 8 10
CDC25C 0.008 0.043 -10000 0 -0.3 3 3
CDC25B 0.027 0.011 -10000 0 -10000 0 0
SGOL1 0.004 0.032 0.13 5 -0.14 5 10
RHOA 0.027 0.006 -10000 0 -10000 0 0
CCNB1/CDK1 0.037 0.029 -10000 0 -10000 0 0
CDC14B 0.006 0.003 -10000 0 -10000 0 0
CDC20 0.015 0.031 -10000 0 -10000 0 0
PLK1/PBIP1 0.007 0.026 0.12 2 -10000 0 2
mitosis -0.002 0.003 -10000 0 -10000 0 0
FBXO5 0.007 0.029 0.13 4 -10000 0 4
CDC2 0.001 0.002 -10000 0 -10000 0 0
NDC80 0.016 0.03 -10000 0 -10000 0 0
metaphase plate congression -0.005 0.074 -10000 0 -0.24 18 18
ERCC6L 0.014 0.031 -10000 0 -10000 0 0
NLP/gamma Tubulin 0.01 0.025 0.11 9 -10000 0 9
microtubule cytoskeleton organization 0.005 0.045 0.11 2 -0.2 8 10
G2/M transition DNA damage checkpoint 0 0.002 0.013 2 -10000 0 2
PPP1R12A 0.027 0.006 -10000 0 -10000 0 0
interphase 0 0.002 0.013 2 -10000 0 2
PLK1/PRC1-2 0.022 0.042 -10000 0 -10000 0 0
GRASP65/GM130/RAB1/GTP/PLK1 0.047 0.028 -10000 0 -10000 0 0
RAB1A 0.028 0.004 -10000 0 -10000 0 0
prophase 0 0 -10000 0 -10000 0 0
Aurora A/BORA 0.008 0.026 0.1 11 -10000 0 11
mitotic prometaphase 0.001 0.005 0.017 18 -10000 0 18
proteasomal ubiquitin-dependent protein catabolic process 0.021 0.023 -10000 0 -0.26 1 1
microtubule-based process 0.009 0.035 0.15 1 -10000 0 1
Golgi organization 0.01 0.031 0.12 9 -10000 0 9
Cohesin/SA2 0.026 0.023 0.13 2 -10000 0 2
PPP1CB/MYPT1 0.039 0.011 -10000 0 -10000 0 0
KIF20A -0.006 0.047 -10000 0 -10000 0 0
APC/C/CDC20 0.023 0.029 0.15 1 -10000 0 1
PPP2R1A 0.028 0.003 -10000 0 -10000 0 0
chromosome segregation 0.007 0.026 0.12 2 -10000 0 2
PRC1 0.023 0.021 -10000 0 -10000 0 0
ECT2 0.013 0.055 0.28 7 -10000 0 7
C13orf34 0.008 0.025 0.1 9 -10000 0 9
NUDC -0.005 0.074 -10000 0 -0.24 18 18
regulation of attachment of spindle microtubules to kinetochore 0.008 0.037 0.15 5 -0.17 1 6
spindle assembly 0.013 0.038 0.14 12 -10000 0 12
spindle stabilization 0.014 0.027 0.13 8 -10000 0 8
APC/C/HCDH1 0.024 0.006 -10000 0 -10000 0 0
MKLP2/PLK1 0.01 0.035 0.15 1 -10000 0 1
CCNB1 0.027 0.014 -10000 0 -10000 0 0
PPP1CB 0.028 0.005 -10000 0 -10000 0 0
BTRC 0.028 0.003 -10000 0 -10000 0 0
ROCK2 0.01 0.07 0.28 1 -0.33 6 7
TUBG1 0.014 0.024 0.14 5 -10000 0 5
G2/M transition of mitotic cell cycle 0.005 0.021 -10000 0 -10000 0 0
MLF1IP 0.001 0.017 -10000 0 -10000 0 0
INCENP 0.028 0.002 -10000 0 -10000 0 0
Class I PI3K signaling events mediated by Akt

Figure S80.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S80.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.013 0.003 -10000 0 -10000 0 0
BAD/BCL-XL/YWHAZ 0.044 0.013 -10000 0 -10000 0 0
CDKN1B 0.001 0.1 -10000 0 -0.45 4 4
CDKN1A 0.003 0.083 -10000 0 -0.28 13 13
FRAP1 0 0 -10000 0 -10000 0 0
PRKDC 0.027 0.005 -10000 0 -10000 0 0
FOXO3 0.003 0.082 -10000 0 -0.29 2 2
AKT1 -0.007 0.097 -10000 0 -0.35 13 13
BAD 0.028 0.002 -10000 0 -10000 0 0
AKT3 0.013 0.005 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
FOXO4 -0.003 0.1 -10000 0 -0.33 15 15
AKT1/ASK1 0.016 0.11 -10000 0 -0.43 4 4
BAD/YWHAZ 0.055 0.01 -10000 0 -10000 0 0
RICTOR 0.027 0.005 -10000 0 -10000 0 0
RAF1 0.027 0.006 -10000 0 -10000 0 0
JNK cascade -0.013 0.1 0.42 4 -10000 0 4
TSC1 0.005 0.077 -10000 0 -0.28 11 11
YWHAZ 0.027 0.004 -10000 0 -10000 0 0
AKT1/RAF1 0.017 0.11 0.28 1 -0.33 14 15
EP300 0.025 0.009 -10000 0 -10000 0 0
mol:GDP -0.003 0.1 -10000 0 -0.34 15 15
mol:PI-3-4-5-P3 0 0 -10000 0 -10000 0 0
TSC2 -0.01 0.098 -10000 0 -0.45 4 4
YWHAQ 0.027 0.005 -10000 0 -10000 0 0
TBC1D4 0.006 0.003 -10000 0 -10000 0 0
MAP3K5 0.027 0.005 -10000 0 -10000 0 0
MAPKAP1 0.027 0.007 -10000 0 -10000 0 0
negative regulation of cell cycle -0.018 0.1 0.42 5 -0.27 7 12
YWHAH 0.025 0.008 -10000 0 -10000 0 0
AKT1S1 0 0.098 -10000 0 -0.51 3 3
CASP9 0.012 0.063 -10000 0 -0.29 1 1
YWHAB 0.027 0.006 -10000 0 -10000 0 0
p27Kip1/KPNA1 0.02 0.11 0.34 4 -0.58 2 6
GBL 0 0 -10000 0 -10000 0 0
PDK1/Src/Hsp90 0.046 0.023 -10000 0 -10000 0 0
YWHAE 0.026 0.008 -10000 0 -10000 0 0
SRC 0.026 0.009 -10000 0 -10000 0 0
AKT2/p21CIP1 -0.004 0.087 -10000 0 -0.55 2 2
KIAA1303 0 0 -10000 0 -10000 0 0
mTOR/RHEB/GTP/Raptor/GBL 0.007 0.029 -10000 0 -10000 0 0
CHUK -0.001 0.1 -10000 0 -0.62 2 2
BAD/BCL-XL 0.017 0.1 -10000 0 -0.58 2 2
mTORC2 0.033 0.01 -10000 0 -10000 0 0
AKT2 0.014 0.005 -10000 0 -10000 0 0
FOXO1-3a-4/14-3-3 family 0.01 0.14 0.32 7 -0.61 5 12
PDPK1 0.025 0.008 -10000 0 -10000 0 0
MDM2 0.001 0.1 -10000 0 -0.33 14 14
MAPKKK cascade -0.017 0.11 0.32 14 -0.28 1 15
MDM2/Cbp/p300 0.019 0.1 -10000 0 -0.56 2 2
TSC1/TSC2 0.012 0.12 0.27 16 -0.58 2 18
proteasomal ubiquitin-dependent protein catabolic process 0.018 0.097 -10000 0 -0.53 2 2
glucose import 0.006 0.043 0.21 6 -0.38 1 7
mTOR/RHEB/GDP/Raptor/GBL/PRAS40 0.012 0.063 0.18 1 -0.35 2 3
response to stress 0 0 -10000 0 -10000 0 0
SLC2A4 0.001 0.03 0.21 1 -0.38 1 2
GSK3A 0 0.098 -10000 0 -0.34 13 13
FOXO1 0.006 0.074 -10000 0 -0.28 10 10
GSK3B -0.003 0.1 -10000 0 -0.33 15 15
SFN -0.019 0.048 -10000 0 -10000 0 0
G1/S transition of mitotic cell cycle 0.003 0.11 0.3 4 -0.6 2 6
p27Kip1/14-3-3 family 0.035 0.052 -10000 0 -10000 0 0
PRKACA 0.028 0.002 -10000 0 -10000 0 0
KPNA1 0.027 0.006 -10000 0 -10000 0 0
HSP90AA1 0.026 0.008 -10000 0 -10000 0 0
YWHAG 0.023 0.011 -10000 0 -10000 0 0
RHEB 0.023 0.011 -10000 0 -10000 0 0
CREBBP 0.025 0.008 -10000 0 -10000 0 0
IL1-mediated signaling events

Figure S81.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S81.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
UBC13/UEV1A 0.033 0.01 -9999 0 -10000 0 0
PRKCZ 0.025 0.008 -9999 0 -10000 0 0
MAP3K7IP2 0 0 -9999 0 -10000 0 0
ERC1 0.027 0.006 -9999 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 0.018 0.045 -9999 0 -10000 0 0
IRAK/TOLLIP 0.028 0.009 -9999 0 -10000 0 0
IKBKB 0.027 0.005 -9999 0 -10000 0 0
IKBKG 0.028 0.002 -9999 0 -10000 0 0
IL1 alpha/IL1R2 -0.075 0.21 -9999 0 -0.5 40 40
IL1A 0.009 0.036 -9999 0 -10000 0 0
IL1B 0.003 0.07 -9999 0 -0.5 4 4
IRAK/TRAF6/p62/Atypical PKCs 0.062 0.036 -9999 0 -10000 0 0
IL1R2 -0.1 0.27 -9999 0 -0.66 40 40
IL1R1 0.028 0.003 -9999 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP 0.011 0.041 -9999 0 -10000 0 0
TOLLIP 0.028 0.004 -9999 0 -10000 0 0
TICAM2 0.024 0.047 -9999 0 -0.66 1 1
MAP3K3 0.026 0.008 -9999 0 -10000 0 0
TAK1/TAB1/TAB2 0.019 0.003 -9999 0 -10000 0 0
IKK complex/ELKS 0.036 0.052 -9999 0 -10000 0 0
JUN -0.011 0.042 -9999 0 -0.33 1 1
MAP3K7 0.027 0.005 -9999 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/PI3K 0.061 0.056 -9999 0 -0.37 3 3
IL1 alpha/IL1R1/IL1RAP/MYD88 0.064 0.021 -9999 0 -10000 0 0
PIK3R1 0.027 0.004 -9999 0 -10000 0 0
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 0.072 0.027 -9999 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP 0.035 0.057 -9999 0 -0.4 3 3
NFKB1 0.027 0.006 -9999 0 -10000 0 0
MAPK8 -0.009 0.043 -9999 0 -0.35 1 1
IRAK1 -0.007 0.013 -9999 0 -10000 0 0
IL1RN/IL1R1 0.034 0.029 -9999 0 -0.21 1 1
IRAK4 0.027 0.006 -9999 0 -10000 0 0
PRKCI 0.027 0.005 -9999 0 -10000 0 0
TRAF6 0.028 0.004 -9999 0 -10000 0 0
PI3K 0.04 0.009 -9999 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP 0.019 0.045 -9999 0 -10000 0 0
CHUK 0.028 0.003 -9999 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/MYD88s 0.035 0.057 -9999 0 -0.4 3 3
IL1 beta/IL1R2 -0.063 0.19 -9999 0 -0.43 44 44
IRAK/TRAF6/TAK1/TAB1/TAB2 0.035 0.013 -9999 0 -10000 0 0
NF kappa B1 p50/RelA 0.046 0.052 -9999 0 -0.34 3 3
IRAK3 0.027 0.009 -9999 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 0.058 0.064 -9999 0 -0.37 4 4
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP 0.023 0.027 -9999 0 -10000 0 0
IL1 alpha/IL1R1/IL1RAP 0.039 0.036 -9999 0 -10000 0 0
RELA 0.028 0.002 -9999 0 -10000 0 0
MAP3K7IP1 0 0 -9999 0 -10000 0 0
SQSTM1 0.025 0.015 -9999 0 -10000 0 0
MYD88 0.027 0.006 -9999 0 -10000 0 0
IRAK/TRAF6/MEKK3 0.047 0.03 -9999 0 -10000 0 0
IL1RAP 0.026 0.011 -9999 0 -10000 0 0
UBE2N 0.027 0.005 -9999 0 -10000 0 0
IRAK/TRAF6 0.027 0.047 -9999 0 -10000 0 0
CASP1 0.027 0.009 -9999 0 -10000 0 0
IL1RN/IL1R2 -0.068 0.21 -9999 0 -0.49 41 41
IL1 beta fragment/IL1R1/IL1RAP/MYD88 0.051 0.055 -9999 0 -0.38 3 3
TMEM189-UBE2V1 -0.008 0.02 -9999 0 -10000 0 0
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP 0.022 0.046 -9999 0 -10000 0 0
PIK3CA 0.027 0.005 -9999 0 -10000 0 0
IL1RN 0.019 0.036 -9999 0 -0.34 1 1
TRAF6/TAK1/TAB1/TAB2 0.046 0.016 -9999 0 -10000 0 0
MAP2K6 -0.005 0.036 -9999 0 -10000 0 0
S1P5 pathway

Figure S82.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S82.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:S1P 0 0 -10000 0 -10000 0 0
telencephalon oligodendrocyte cell migration -0.013 0.091 0.28 12 -10000 0 12
GNAI2 0.027 0.007 -10000 0 -10000 0 0
S1P/S1P5/G12 0.024 0.048 -10000 0 -0.43 2 2
mol:GDP 0 0 -10000 0 -10000 0 0
GNAO1 -0.011 0.15 -10000 0 -0.66 11 11
RhoA/GTP 0.013 0.092 -10000 0 -0.28 12 12
negative regulation of cAMP metabolic process 0.006 0.092 -10000 0 -0.3 12 12
GNAZ 0.025 0.008 -10000 0 -10000 0 0
GNAI3 0.027 0.006 -10000 0 -10000 0 0
GNA12 0.023 0.011 -10000 0 -10000 0 0
S1PR5 0.019 0.068 -10000 0 -0.66 2 2
mol:GTP 0 0 -10000 0 -10000 0 0
S1P/S1P5/Gi 0.006 0.093 -10000 0 -0.31 12 12
RhoA/GDP 0.02 0.005 -10000 0 -10000 0 0
RHOA 0.027 0.006 -10000 0 -10000 0 0
GNAI1 0.019 0.048 -10000 0 -0.66 1 1
Canonical Wnt signaling pathway

Figure S83.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S83.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.023 0.008 -10000 0 -10000 0 0
AES 0.025 0.005 -10000 0 -10000 0 0
FBXW11 0.027 0.005 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
LRP6/FZD1 0.033 0.019 -10000 0 -10000 0 0
SMAD4 0.026 0.008 -10000 0 -10000 0 0
DKK2 0.021 0.049 -10000 0 -0.66 1 1
TLE1 0.024 0.008 -10000 0 -10000 0 0
MACF1 0.027 0.008 -10000 0 -10000 0 0
CTNNB1 0.067 0.11 0.42 10 -10000 0 10
WIF1 0.009 0.025 -10000 0 -10000 0 0
beta catenin/RanBP3 0.02 0.061 0.35 1 -10000 0 1
KREMEN2 0.013 0.03 -10000 0 -10000 0 0
DKK1 0.013 0.029 -10000 0 -10000 0 0
beta catenin/beta TrCP1 0.072 0.1 0.42 7 -10000 0 7
FZD1 0.022 0.013 -10000 0 -10000 0 0
AXIN2 0.053 0.16 0.57 16 -10000 0 16
AXIN1 0.026 0.009 -10000 0 -10000 0 0
RAN 0.027 0.006 -10000 0 -10000 0 0
Axin1/APC/GSK3/beta catenin 0.026 0.062 -10000 0 -0.57 2 2
beta catenin/TCF/CtBP/CBP/TLE1/AES/SMAD4 0.008 0.15 0.3 1 -0.55 8 9
Axin1/APC/GSK3 0.045 0.076 0.3 2 -0.42 1 3
Axin1/APC/GSK3/beta catenin/Macf1 0.05 0.088 0.45 3 -0.37 1 4
HNF1A 0.011 0.094 -10000 0 -0.66 4 4
CTBP1 0.024 0.007 -10000 0 -10000 0 0
MYC 0.013 0.062 0.6 1 -10000 0 1
RANBP3 0.028 0.003 -10000 0 -10000 0 0
DKK2/LRP6/Kremen 2 0.037 0.046 -10000 0 -0.43 1 1
NKD1 -0.14 0.29 -10000 0 -0.66 52 52
TCF4 0.023 0.008 -10000 0 -10000 0 0
TCF3 0.025 0.005 -10000 0 -10000 0 0
WNT1/LRP6/FZD1/Axin1 0.051 0.032 -10000 0 -10000 0 0
Ran/GTP 0.02 0.004 -10000 0 -10000 0 0
CtBP/CBP/TCF/TLE1/AES -0.03 0.1 0.42 1 -0.38 10 11
LEF1 -0.025 0.18 -10000 0 -0.66 15 15
DVL1 0.019 0.051 -10000 0 -0.56 1 1
CSNK2A1 0.027 0.006 -10000 0 -10000 0 0
beta catenin/TCF/CtBP/CBP/TLE1/AES 0.037 0.11 0.37 1 -0.47 2 3
DKK1/LRP6/Kremen 2 0.035 0.037 -10000 0 -10000 0 0
LRP6 0.027 0.006 -10000 0 -10000 0 0
CSNK1A1 0.025 0.007 -10000 0 -10000 0 0
NLK 0.027 0.008 -10000 0 -10000 0 0
CCND1 0.005 0.12 0.9 1 -1.4 1 2
WNT1 0.013 0.032 -10000 0 -10000 0 0
GSK3A 0.029 0.005 -10000 0 -10000 0 0
GSK3B 0.027 0.006 -10000 0 -10000 0 0
FRAT1 0.028 0.003 -10000 0 -10000 0 0
PPP2R5D 0.074 0.15 0.32 48 -0.39 1 49
APC 0.057 0.13 0.53 9 -10000 0 9
WNT1/LRP6/FZD1 0.016 0.026 -10000 0 -10000 0 0
CREBBP 0.023 0.009 -10000 0 -10000 0 0
Wnt signaling

Figure S84.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S84.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Noncanonical Wnts/FZD 0.001 0.081 -9999 0 -0.3 12 12
FZD6 0.027 0.004 -9999 0 -10000 0 0
WNT6 0.019 0.049 -9999 0 -0.66 1 1
WNT4 0.012 0.094 -9999 0 -0.66 4 4
FZD3 0.027 0.006 -9999 0 -10000 0 0
WNT5A 0.011 0.036 -9999 0 -10000 0 0
WNT11 -0.001 0.13 -9999 0 -0.66 8 8
LPA receptor mediated events

Figure S85.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S85.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GNB1/GNG2 0.047 0.043 -10000 0 -0.49 1 1
NF kappa B1 p50/RelA/I kappa B alpha 0.01 0.092 0.33 1 -10000 0 1
AP1 -0.015 0.14 -10000 0 -0.36 27 27
mol:PIP3 0.01 0.014 -10000 0 -10000 0 0
AKT1 0.039 0.072 0.35 5 -10000 0 5
PTK2B 0.001 0.06 -10000 0 -0.37 2 2
RHOA 0.021 0.06 -10000 0 -0.27 4 4
PIK3CB 0.027 0.006 -10000 0 -10000 0 0
mol:Ca2+ -0.013 0.08 0.32 1 -10000 0 1
MAGI3 0.027 0.006 -10000 0 -10000 0 0
RELA 0.028 0.002 -10000 0 -10000 0 0
apoptosis 0.013 0.034 -10000 0 -0.45 1 1
HRAS/GDP 0.021 0.002 -10000 0 -10000 0 0
positive regulation of microtubule depolymerization 0.001 0.12 0.29 8 -0.38 11 19
NF kappa B1 p50/RelA 0.006 0.069 -10000 0 -10000 0 0
endothelial cell migration 0.016 0.029 -10000 0 -0.38 1 1
ADCY4 0 0.094 -10000 0 -0.39 4 4
ADCY5 -0.001 0.1 -10000 0 -0.44 6 6
ADCY6 0.013 0.069 -10000 0 -0.29 1 1
ADCY7 0.012 0.068 -10000 0 -10000 0 0
ADCY1 -0.08 0.14 -10000 0 -0.53 10 10
ADCY2 0.009 0.07 -10000 0 -0.29 1 1
ADCY3 0.014 0.073 -10000 0 -0.44 1 1
ADCY8 0.014 0.069 -10000 0 -0.29 1 1
ADCY9 0.012 0.068 -10000 0 -10000 0 0
GSK3B 0.004 0.066 0.25 3 -0.35 2 5
arachidonic acid secretion 0.006 0.08 -10000 0 -0.33 3 3
GNG2 0.026 0.007 -10000 0 -10000 0 0
TRIP6 0.018 0.011 -10000 0 -10000 0 0
GNAO1 -0.006 0.098 -10000 0 -0.4 12 12
HRAS 0.028 0.003 -10000 0 -10000 0 0
NFKBIA -0.011 0.09 0.3 2 -10000 0 2
GAB1 0.027 0.007 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
lamellipodium assembly -0.017 0.21 -10000 0 -0.74 15 15
JUN 0.026 0.007 -10000 0 -10000 0 0
LPA/LPA2/NHERF2 0.036 0.014 -10000 0 -10000 0 0
TIAM1 -0.036 0.24 -10000 0 -0.91 15 15
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
mol:IP3 -0.01 0.076 0.32 1 -10000 0 1
PLCB3 0.032 0.048 -10000 0 -10000 0 0
FOS -0.071 0.23 -10000 0 -0.6 33 33
positive regulation of mitosis 0.006 0.08 -10000 0 -0.33 3 3
LPA/LPA1-2-3 0.047 0.041 -10000 0 -0.48 1 1
mol:Ca ++ 0 0 -10000 0 -10000 0 0
JNK cascade 0 0 -10000 0 -10000 0 0
BCAR1 0.026 0.007 -10000 0 -10000 0 0
stress fiber formation 0.012 0.057 -10000 0 -0.43 2 2
GNAZ 0.015 0.038 -10000 0 -0.52 1 1
EGFR/PI3K-beta/Gab1 0.021 0.019 -10000 0 -10000 0 0
positive regulation of dendritic cell cytokine production 0.046 0.04 -10000 0 -0.48 1 1
LPA/LPA2/MAGI-3 0.037 0.018 -10000 0 -10000 0 0
ARHGEF1 0.06 0.084 0.36 5 -10000 0 5
GNAI2 0.016 0.025 -10000 0 -0.33 1 1
GNAI3 0.016 0.037 -10000 0 -0.52 1 1
GNAI1 0.012 0.039 -10000 0 -0.38 2 2
LPA/LPA3 0.015 0.018 -10000 0 -0.21 1 1
LPA/LPA2 0.021 0.016 -10000 0 -0.2 1 1
LPA/LPA1 0.022 0.043 -10000 0 -0.59 1 1
HB-EGF/EGFR -0.005 0.06 -10000 0 -0.43 3 3
HBEGF -0.016 0.067 -10000 0 -0.44 4 4
mol:DAG -0.01 0.076 0.32 1 -10000 0 1
cAMP biosynthetic process -0.004 0.12 0.39 5 -0.37 9 14
NFKB1 0.027 0.006 -10000 0 -10000 0 0
SRC 0.026 0.009 -10000 0 -10000 0 0
GNB1 0.025 0.008 -10000 0 -10000 0 0
LYN -0.004 0.083 0.29 3 -10000 0 3
GNAQ 0.014 0.014 -10000 0 -10000 0 0
LPAR2 0.027 0.007 -10000 0 -10000 0 0
LPAR3 -0.003 0.024 -10000 0 -10000 0 0
LPAR1 0.027 0.024 -10000 0 -0.3 1 1
IL8 -0.024 0.11 0.43 1 -0.42 6 7
PTK2 0.013 0.028 -10000 0 -10000 0 0
Rac1/GDP 0.017 0.008 -10000 0 -10000 0 0
CASP3 0.013 0.035 -10000 0 -0.45 1 1
EGFR 0.022 0.011 -10000 0 -10000 0 0
PLCG1 -0.02 0.068 -10000 0 -0.32 2 2
PLD2 0.013 0.028 -10000 0 -10000 0 0
G12/G13 0.041 0.03 -10000 0 -10000 0 0
PI3K-beta 0.013 0.035 -10000 0 -10000 0 0
cell migration 0.01 0.067 -10000 0 -0.24 10 10
SLC9A3R2 0.025 0.008 -10000 0 -10000 0 0
PXN 0.012 0.058 -10000 0 -0.44 2 2
HRAS/GTP 0.007 0.079 -10000 0 -0.34 3 3
RAC1 0.022 0.011 -10000 0 -10000 0 0
MMP9 -0.013 0.078 -10000 0 -0.66 2 2
PRKCE 0.027 0.004 -10000 0 -10000 0 0
PRKCD -0.011 0.084 0.31 3 -10000 0 3
Gi(beta/gamma) 0.013 0.077 -10000 0 -0.47 2 2
mol:LPA 0.002 0.02 -10000 0 -0.29 1 1
TRIP6/p130 Cas/FAK1/Paxillin 0.046 0.061 -10000 0 -0.39 1 1
MAPKKK cascade 0.006 0.08 -10000 0 -0.33 3 3
contractile ring contraction involved in cytokinesis 0.023 0.068 0.26 1 -0.29 5 6
mol:GDP 0 0 -10000 0 -10000 0 0
GNA14 -0.063 0.15 -10000 0 -0.36 43 43
GNA15 0.011 0.018 -10000 0 -10000 0 0
GNA12 0.023 0.011 -10000 0 -10000 0 0
GNA13 0.026 0.008 -10000 0 -10000 0 0
MAPT 0 0.12 0.3 8 -0.39 11 19
GNA11 0.004 0.061 -10000 0 -0.37 5 5
Rac1/GTP -0.018 0.22 -10000 0 -0.78 15 15
MMP2 0.016 0.029 -10000 0 -0.38 1 1
IGF1 pathway

Figure S86.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S86.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NCK2 0.028 0.003 -10000 0 -10000 0 0
PTK2 0.027 0.004 -10000 0 -10000 0 0
CRKL 0.002 0.065 -10000 0 -0.32 8 8
GRB2/SOS1/SHC 0.05 0.019 -10000 0 -10000 0 0
HRAS 0.028 0.003 -10000 0 -10000 0 0
IRS1/Crk 0.011 0.068 -10000 0 -0.32 8 8
IGF-1R heterotetramer/IGF1/PTP1B 0.039 0.069 -10000 0 -0.41 4 4
AKT1 -0.017 0.056 0.27 1 -0.31 4 5
BAD -0.018 0.053 0.26 1 -0.3 3 4
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.002 0.065 -10000 0 -0.32 8 8
IGF-1R heterotetramer/IGF1/IRS1/Shp2 0.017 0.069 -10000 0 -0.32 8 8
RAF1 -0.003 0.083 -10000 0 -0.49 3 3
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos 0.045 0.072 -10000 0 -0.3 7 7
YWHAZ 0.027 0.004 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1 0.019 0.075 -10000 0 -0.35 8 8
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
RPS6KB1 -0.017 0.057 0.27 1 -0.31 4 5
GNB2L1 0.027 0.005 -10000 0 -10000 0 0
positive regulation of MAPKKK cascade 0.001 0.081 0.26 3 -0.37 3 6
PXN 0.027 0.006 -10000 0 -10000 0 0
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
cell adhesion 0 0 -10000 0 -10000 0 0
GRB2/SOS1 0.038 0.013 -10000 0 -10000 0 0
HRAS/GTP 0.02 0.058 -10000 0 -0.31 4 4
IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc 0.062 0.065 -10000 0 -0.33 4 4
IGF-1R heterotetramer 0.026 0.026 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS/Nck 0.034 0.074 -10000 0 -0.32 8 8
Crk/p130 Cas/Paxillin 0.045 0.077 -10000 0 -0.3 8 8
IGF1R 0.026 0.026 -10000 0 -10000 0 0
IGF1 0.01 0.11 -10000 0 -0.67 5 5
IRS2/Crk 0.011 0.065 -10000 0 -0.3 8 8
PI3K 0.046 0.075 -10000 0 -0.31 8 8
apoptosis 0 0.086 -10000 0 -0.32 8 8
HRAS/GDP 0.021 0.002 -10000 0 -10000 0 0
PRKCD 0.005 0.073 -10000 0 -0.42 5 5
RAF1/14-3-3 E 0.015 0.091 0.28 2 -0.42 3 5
BAD/14-3-3 0 0.09 0.33 8 -10000 0 8
PRKCZ -0.015 0.055 0.27 1 -0.31 3 4
Crk/p130 Cas/Paxillin/FAK1 0.021 0.057 -10000 0 -10000 0 0
PTPN1 0.027 0.006 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 0.007 0.077 -10000 0 -0.44 5 5
BCAR1 0.026 0.007 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/SHC/GRB10 0.043 0.068 -10000 0 -0.36 4 4
mol:GDP 0 0 -10000 0 -10000 0 0
SOS1 0.027 0.004 -10000 0 -10000 0 0
IRS1/NCK2 0.021 0.073 -10000 0 -0.32 8 8
GRB10 0.023 0.011 -10000 0 -10000 0 0
PTPN11 0.003 0.066 -10000 0 -0.32 8 8
IRS1 0.005 0.074 -10000 0 -0.35 8 8
IRS2 0.002 0.065 -10000 0 -0.32 8 8
IGF-1R heterotetramer/IGF1 0.024 0.087 -10000 0 -0.51 5 5
GRB2 0.026 0.008 -10000 0 -10000 0 0
PDPK1 0.003 0.062 0.27 1 -0.32 4 5
YWHAE 0.026 0.008 -10000 0 -10000 0 0
PRKD1 0.005 0.074 -10000 0 -0.43 5 5
SHC1 0.027 0.005 -10000 0 -10000 0 0
S1P4 pathway

Figure S87.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S87.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:S1P 0 0 -10000 0 -10000 0 0
GNAO1 -0.011 0.15 -10000 0 -0.66 11 11
CDC42/GTP 0.016 0.088 -10000 0 -0.29 10 10
PLCG1 0.002 0.085 -10000 0 -0.3 10 10
mol:GTP 0 0 -10000 0 -10000 0 0
GNAI2 0.027 0.007 -10000 0 -10000 0 0
GNAI3 0.027 0.006 -10000 0 -10000 0 0
G12/G13 0.031 0.018 -10000 0 -10000 0 0
cell migration 0.015 0.086 -10000 0 -0.28 10 10
S1PR5 0.019 0.068 -10000 0 -0.66 2 2
S1PR4 0.026 0.012 -10000 0 -10000 0 0
MAPK3 0.001 0.085 -10000 0 -0.3 10 10
MAPK1 0.011 0.077 -10000 0 -0.3 10 10
S1P/S1P5/Gi 0.006 0.093 -10000 0 -0.31 12 12
GNAI1 0.019 0.048 -10000 0 -0.66 1 1
CDC42/GDP 0.019 0.006 -10000 0 -10000 0 0
S1P/S1P5/G12 0.024 0.048 -10000 0 -0.43 2 2
RHOA 0.053 0.079 0.35 4 -10000 0 4
S1P/S1P4/Gi 0.009 0.089 -10000 0 -0.31 10 10
mol:GDP 0 0 -10000 0 -10000 0 0
GNAZ 0.025 0.008 -10000 0 -10000 0 0
S1P/S1P4/G12/G13 0.039 0.025 -10000 0 -10000 0 0
GNA12 0.023 0.011 -10000 0 -10000 0 0
GNA13 0.026 0.008 -10000 0 -10000 0 0
CDC42 0.026 0.008 -10000 0 -10000 0 0
IL12-mediated signaling events

Figure S88.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S88.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IL12/IL12R/TYK2/JAK2/SOCS1 0.013 0.063 -10000 0 -0.4 2 2
TBX21 0.01 0.19 -10000 0 -0.83 3 3
B2M 0.028 0.006 -10000 0 -10000 0 0
TYK2 0.025 0.026 -10000 0 -10000 0 0
IL12RB1 0.019 0.036 -10000 0 -10000 0 0
GADD45B 0.015 0.19 -10000 0 -0.79 4 4
IL12RB2 -0.025 0.079 -10000 0 -0.67 2 2
GADD45G -0.002 0.21 -10000 0 -0.98 4 4
natural killer cell activation 0.004 0.013 -10000 0 -10000 0 0
RELB 0.028 0.003 -10000 0 -10000 0 0
RELA 0.028 0.002 -10000 0 -10000 0 0
IL18 0.025 0.022 -10000 0 -10000 0 0
IL2RA 0.016 0.031 -10000 0 -10000 0 0
IFNG 0.003 0.031 -10000 0 -10000 0 0
STAT3 (dimer) 0.01 0.17 -10000 0 -0.58 6 6
HLA-DRB5 0.01 0.072 -10000 0 -0.67 2 2
FASLG 0.002 0.19 -10000 0 -1 2 2
NF kappa B2 p52/RelB 0.017 0.19 -10000 0 -0.71 6 6
CD4 0.018 0.025 -10000 0 -10000 0 0
SOCS1 0.022 0.048 -10000 0 -0.66 1 1
EntrezGene:6955 -0.002 0.009 -10000 0 -10000 0 0
CD3D 0.005 0.04 -10000 0 -10000 0 0
CD3E 0.011 0.056 -10000 0 -0.66 1 1
CD3G 0.015 0.03 -10000 0 -10000 0 0
IL12Rbeta2/JAK2 0.012 0.069 -10000 0 -0.52 2 2
CCL3 0.004 0.21 -10000 0 -1.1 3 3
CCL4 0.007 0.19 -10000 0 -0.77 4 4
HLA-A 0.027 0.009 -10000 0 -10000 0 0
IL18/IL18R 0.06 0.06 -10000 0 -0.43 1 1
NOS2 -0.043 0.35 -10000 0 -1.2 18 18
IL12/IL12R/TYK2/JAK2/SPHK2 0.016 0.059 -10000 0 -0.37 1 1
IL1R1 0.001 0.18 -10000 0 -0.71 6 6
IL4 -0.009 0.029 -10000 0 -10000 0 0
JAK2 0.023 0.027 -10000 0 -10000 0 0
EntrezGene:6957 -0.002 0.008 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8 0.007 0.057 -10000 0 -10000 0 0
RAB7A 0.023 0.18 -10000 0 -0.61 3 3
lysosomal transport 0.024 0.17 -10000 0 -0.58 3 3
FOS -0.18 0.5 -10000 0 -1.2 38 38
STAT4 (dimer) 0.016 0.18 0.5 1 -0.68 4 5
STAT5A (dimer) 0.013 0.18 -10000 0 -0.77 4 4
GZMA 0.002 0.18 -10000 0 -1 2 2
GZMB 0 0.19 -10000 0 -1.1 3 3
HLX 0.026 0.009 -10000 0 -10000 0 0
LCK 0.001 0.19 -10000 0 -0.76 6 6
TCR/CD3/MHC II/CD4 -0.015 0.11 -10000 0 -0.44 8 8
IL2/IL2R 0.049 0.038 -10000 0 -10000 0 0
MAPK14 0.015 0.2 -10000 0 -0.61 8 8
CCR5 0.013 0.17 -10000 0 -0.63 2 2
IL1B 0.012 0.1 -10000 0 -0.68 4 4
STAT6 0.021 0.066 -10000 0 -10000 0 0
STAT4 0.02 0.027 -10000 0 -10000 0 0
STAT3 0.026 0.008 -10000 0 -10000 0 0
STAT1 0.027 0.01 -10000 0 -10000 0 0
NFKB1 0.027 0.006 -10000 0 -10000 0 0
NFKB2 0.028 0.003 -10000 0 -10000 0 0
IL12B 0.02 0.027 -10000 0 -10000 0 0
CD8A 0.019 0.03 -10000 0 -10000 0 0
CD8B 0.021 0.027 -10000 0 -10000 0 0
T-helper 1 cell differentiation 0 0 -10000 0 -10000 0 0
natural killer cell mediated cytotoxicity -0.012 0.064 0.4 2 -10000 0 2
IL2RB 0.015 0.031 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.017 0.17 0.5 1 -0.63 4 5
IL2RG 0.025 0.018 -10000 0 -10000 0 0
IL12 0.034 0.039 -10000 0 -10000 0 0
STAT5A 0.026 0.008 -10000 0 -10000 0 0
CD247 0.017 0.026 -10000 0 -10000 0 0
IL2 -0.002 0.023 -10000 0 -10000 0 0
SPHK2 0.028 0.003 -10000 0 -10000 0 0
FRAP1 0 0 -10000 0 -10000 0 0
IL12A 0.023 0.027 -10000 0 -10000 0 0
IL12/IL12R/TYK2/JAK2 0.001 0.2 -10000 0 -0.8 6 6
MAP2K3 0.012 0.19 -10000 0 -0.59 9 9
RIPK2 0.027 0.004 -10000 0 -10000 0 0
MAP2K6 0.015 0.19 -10000 0 -0.6 8 8
regulation of dendritic cell antigen processing and presentation 0 0 -10000 0 -10000 0 0
HLA-DRA 0.016 0.052 -10000 0 -0.66 1 1
IL18RAP 0.014 0.037 -10000 0 -10000 0 0
IL12Rbeta1/TYK2 0.035 0.041 -10000 0 -10000 0 0
EOMES -0.003 0.087 -10000 0 -0.55 4 4
STAT1 (dimer) 0.024 0.17 -10000 0 -0.6 5 5
T cell proliferation 0.01 0.16 -10000 0 -0.49 8 8
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
IL18R1 0.023 0.05 -10000 0 -0.66 1 1
CD8-positive alpha-beta T cell lineage commitment 0 0 -10000 0 -10000 0 0
NF kappa B1 p50/RelA 0.018 0.18 -10000 0 -0.61 4 4
ATF2 0.016 0.19 0.4 1 -0.59 7 8
BARD1 signaling events

Figure S89.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S89.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BARD1/CSTF1 0.023 0.09 -10000 0 -0.5 6 6
ATM 0.027 0.005 -10000 0 -10000 0 0
UBE2D3 0.027 0.006 -10000 0 -10000 0 0
PRKDC 0.027 0.005 -10000 0 -10000 0 0
ATR 0.027 0.006 -10000 0 -10000 0 0
UBE2L3 0.026 0.008 -10000 0 -10000 0 0
FANCD2 0.021 0.007 -10000 0 -10000 0 0
protein ubiquitination 0.051 0.078 -10000 0 -0.38 6 6
XRCC5 0.027 0.005 -10000 0 -10000 0 0
XRCC6 0.025 0.008 -10000 0 -10000 0 0
M/R/N Complex 0.052 0.016 -10000 0 -10000 0 0
MRE11A 0.027 0.005 -10000 0 -10000 0 0
DNA-PK 0.05 0.019 -10000 0 -10000 0 0
FA complex/FANCD2/Ubiquitin 0.01 0.088 -10000 0 -0.45 5 5
FANCF 0.028 0.004 -10000 0 -10000 0 0
BRCA1 0.024 0.014 -10000 0 -10000 0 0
CCNE1 0.02 0.027 -10000 0 -10000 0 0
CDK2/Cyclin E1 0.033 0.025 -10000 0 -10000 0 0
FANCG 0.027 0.006 -10000 0 -10000 0 0
BRCA1/BACH1/BARD1 0.021 0.09 -10000 0 -0.5 6 6
FANCE 0.027 0.006 -10000 0 -10000 0 0
FANCC 0.026 0.007 -10000 0 -10000 0 0
NBN 0.027 0.005 -10000 0 -10000 0 0
FANCA -0.011 0.047 -10000 0 -10000 0 0
DNA repair 0.022 0.12 0.4 8 -10000 0 8
BRCA1/BARD1/ubiquitin 0.021 0.09 -10000 0 -0.5 6 6
BARD1/DNA-PK 0.049 0.08 -10000 0 -0.4 6 6
FANCL 0.028 0.004 -10000 0 -10000 0 0
mRNA polyadenylation -0.023 0.089 0.5 6 -10000 0 6
BRCA1/BARD1/CTIP/M/R/N Complex 0.009 0.071 -10000 0 -10000 0 0
BRCA1/BACH1/BARD1/TopBP1 0.034 0.083 -10000 0 -0.43 6 6
BRCA1/BARD1/P53 0.048 0.081 -10000 0 -0.4 6 6
BARD1/CSTF1/BRCA1 0.035 0.083 -10000 0 -0.43 6 6
BRCA1/BACH1 0.024 0.014 -10000 0 -10000 0 0
BARD1 0.007 0.11 -10000 0 -0.66 6 6
PCNA 0.027 0.006 -10000 0 -10000 0 0
BRCA1/BARD1/UbcH5C 0.034 0.083 -10000 0 -0.43 6 6
BRCA1/BARD1/UbcH7 0.032 0.083 -10000 0 -0.43 6 6
BRCA1/BARD1/RAD51/PCNA 0.045 0.081 -10000 0 -0.4 6 6
BARD1/DNA-PK/P53 0.054 0.081 -10000 0 -0.38 6 6
BRCA1/BARD1/Ubiquitin 0.021 0.09 -10000 0 -0.5 6 6
BRCA1/BARD1/CTIP 0.023 0.08 -10000 0 -0.4 7 7
FA complex 0.016 0.036 -10000 0 -10000 0 0
BARD1/EWS 0.022 0.09 -10000 0 -0.5 6 6
RBBP8 0.01 0.035 -10000 0 -0.5 1 1
TP53 0.025 0.008 -10000 0 -10000 0 0
TOPBP1 0.027 0.006 -10000 0 -10000 0 0
G1/S transition of mitotic cell cycle -0.046 0.08 0.4 6 -10000 0 6
BRCA1/BARD1 0.057 0.081 -10000 0 -0.38 6 6
CSTF1 0.027 0.006 -10000 0 -10000 0 0
BARD1/EWS-Fli1 0.006 0.085 -10000 0 -0.49 6 6
CDK2 0.027 0.005 -10000 0 -10000 0 0
UniProt:Q9BZD1 0 0 -10000 0 -10000 0 0
RAD51 0.014 0.034 -10000 0 -10000 0 0
RAD50 0.027 0.005 -10000 0 -10000 0 0
BRCA1/BARD1/DNA-directed RNA polymerase II holoenzyme 0.021 0.09 -10000 0 -0.5 6 6
EWSR1 0.025 0.008 -10000 0 -10000 0 0
EPO signaling pathway

Figure S90.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S90.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.056 0.052 -10000 0 -10000 0 0
CRKL 0.052 0.087 0.37 10 -10000 0 10
mol:DAG 0.028 0.028 -10000 0 -10000 0 0
HRAS 0.044 0.089 0.34 10 -10000 0 10
MAPK8 0.039 0.074 0.25 1 -0.41 1 2
RAP1A 0.054 0.087 0.37 10 -10000 0 10
GAB1 0.053 0.085 0.37 9 -10000 0 9
MAPK14 0.044 0.06 0.25 1 -10000 0 1
EPO 0.022 0.015 -10000 0 -10000 0 0
PLCG1 0.027 0.024 -10000 0 -10000 0 0
EPOR/TRPC2/IP3 Receptors 0.034 0.012 -10000 0 -10000 0 0
RAPGEF1 0.026 0.007 -10000 0 -10000 0 0
EPO/EPOR (dimer)/SOCS3 0.04 0.044 -10000 0 -0.45 1 1
GAB1/SHC/GRB2/SOS1 0.065 0.052 -10000 0 -10000 0 0
EPO/EPOR (dimer) 0.035 0.021 -10000 0 -10000 0 0
IRS2 0.053 0.086 0.37 10 -10000 0 10
STAT1 0.035 0.034 -10000 0 -10000 0 0
STAT5B 0.031 0.033 -10000 0 -10000 0 0
cell proliferation 0.02 0.084 0.32 2 -0.39 1 3
GAB1/SHIP/PIK3R1/SHP2/SHC 0.053 0.037 -10000 0 -10000 0 0
TEC 0.053 0.085 0.37 9 -10000 0 9
SOCS3 0.021 0.049 -10000 0 -0.66 1 1
STAT1 (dimer) 0.035 0.033 -10000 0 -10000 0 0
JAK2 0.032 0.014 -10000 0 -10000 0 0
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
EPO/EPOR (dimer)/JAK2 0.061 0.039 -10000 0 -10000 0 0
EPO/EPOR 0.035 0.021 -10000 0 -10000 0 0
LYN 0.029 0.005 -10000 0 -10000 0 0
TEC/VAV2 0.053 0.052 0.28 3 -10000 0 3
elevation of cytosolic calcium ion concentration 0.034 0.012 -10000 0 -10000 0 0
SHC1 0.027 0.005 -10000 0 -10000 0 0
EPO/EPOR (dimer)/LYN 0.05 0.027 -10000 0 -10000 0 0
mol:IP3 0.028 0.028 -10000 0 -10000 0 0
PI3K regualtory subunit polypeptide 1/IRS2/SHIP 0.074 0.073 0.35 8 -10000 0 8
SH2B3 0.031 0.009 -10000 0 -10000 0 0
NFKB1 0.044 0.059 -10000 0 -10000 0 0
EPO/EPOR (dimer)/JAK2/SOCS3 0.012 0.027 -10000 0 -0.24 1 1
PTPN6 0.04 0.053 -10000 0 -10000 0 0
TEC/VAV2/GRB2 0.06 0.053 0.28 3 -10000 0 3
EPOR 0.035 0.012 -10000 0 -10000 0 0
INPP5D 0.024 0.017 -10000 0 -10000 0 0
mol:GDP 0.065 0.052 -10000 0 -10000 0 0
SOS1 0.027 0.004 -10000 0 -10000 0 0
PLCG2 -0.007 0.14 -10000 0 -0.66 10 10
CRKL/CBL/C3G 0.061 0.056 0.28 4 -10000 0 4
VAV2 0.054 0.087 0.37 10 -10000 0 10
CBL 0.054 0.086 0.37 10 -10000 0 10
SHC/Grb2/SOS1 0.036 0.027 -10000 0 -10000 0 0
STAT5A 0.031 0.033 -10000 0 -10000 0 0
GRB2 0.026 0.008 -10000 0 -10000 0 0
STAT5 (dimer) 0.048 0.039 -10000 0 -10000 0 0
LYN/PLCgamma2 0.014 0.11 -10000 0 -0.47 10 10
PTPN11 0.027 0.006 -10000 0 -10000 0 0
BTK 0.043 0.091 0.36 10 -10000 0 10
BCL2 0.055 0.053 -10000 0 -10000 0 0
mTOR signaling pathway

Figure S91.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S91.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GBL 0 0 -10000 0 -10000 0 0
MKNK1 0.026 0.007 -10000 0 -10000 0 0
mol:PIP3 0.001 0.055 -10000 0 -0.31 4 4
FRAP1 0.018 0.06 0.37 3 -10000 0 3
AKT1 -0.003 0.046 -10000 0 -0.27 4 4
INSR 0.028 0.002 -10000 0 -10000 0 0
Insulin Receptor/Insulin 0.031 0.005 -10000 0 -10000 0 0
mol:GTP 0.017 0.057 -10000 0 -10000 0 0
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA/eIF3/40s Ribosomal subunit 0.011 0.023 -10000 0 -10000 0 0
TSC2 0.025 0.008 -10000 0 -10000 0 0
RHEB/GDP 0.006 0.047 -10000 0 -10000 0 0
TSC1 0.027 0.007 -10000 0 -10000 0 0
Insulin Receptor/IRS1 0.015 0.064 -10000 0 -0.26 10 10
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA 0.023 0.03 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
EIF3A 0.028 0.003 -10000 0 -10000 0 0
RPS6KB1 0.027 0.075 0.39 5 -10000 0 5
MAP3K5 0 0.033 -10000 0 -0.18 7 7
PIK3R1 0.028 0.005 -10000 0 -10000 0 0
apoptosis 0 0.033 -10000 0 -0.18 7 7
mol:LY294002 0 0 -10000 0 -0.001 9 9
EIF4B 0.03 0.092 0.42 8 -10000 0 8
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 0.047 0.067 0.36 5 -10000 0 5
eIF4E/eIF4G1/eIF4A1 0.015 0.024 -10000 0 -10000 0 0
KIAA1303 0 0 -10000 0 -10000 0 0
PI3K 0.03 0.063 -10000 0 -0.3 5 5
mTOR/RHEB/GTP/Raptor/GBL 0.01 0.062 0.31 5 -10000 0 5
FKBP1A 0.027 0.006 -10000 0 -10000 0 0
RHEB/GTP 0.013 0.052 -10000 0 -10000 0 0
mol:Amino Acids 0 0 -10000 0 -0.001 9 9
FKBP12/Rapamycin 0.02 0.005 -10000 0 -10000 0 0
PDPK1 -0.012 0.048 -10000 0 -0.29 4 4
EIF4E 0.027 0.006 -10000 0 -10000 0 0
ASK1/PP5C 0.016 0.12 -10000 0 -0.55 7 7
mTOR/RHEB/GTP/Raptor/GBL/eIF4E 0.016 0.057 -10000 0 -10000 0 0
TSC1/TSC2 0.02 0.061 -10000 0 -10000 0 0
tumor necrosis factor receptor activity 0 0 0.001 9 -10000 0 9
RPS6 0.026 0.007 -10000 0 -10000 0 0
PPP5C 0.028 0.003 -10000 0 -10000 0 0
EIF4G1 0.027 0.005 -10000 0 -10000 0 0
IRS1 -0.003 0.064 0.12 1 -0.27 10 11
INS -0.017 0.008 -10000 0 -10000 0 0
PTEN 0.026 0.007 -10000 0 -10000 0 0
PDK2 -0.008 0.052 0.2 3 -0.31 3 6
EIF4EBP1 0 0.16 -10000 0 -1 5 5
PIK3CA 0.028 0.005 -10000 0 -10000 0 0
PPP2R5D 0.02 0.058 0.36 3 -10000 0 3
peptide biosynthetic process -0.012 0.005 -10000 0 -10000 0 0
RHEB 0.023 0.011 -10000 0 -10000 0 0
EIF4A1 0.025 0.008 -10000 0 -10000 0 0
mol:Rapamycin 0 0.002 0.007 9 -10000 0 9
EEF2 -0.012 0.005 -10000 0 -10000 0 0
eIF4E/4E-BP1 0.015 0.15 -10000 0 -0.93 5 5
Nectin adhesion pathway

Figure S92.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S92.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB -0.002 0.14 -10000 0 -0.66 9 9
alphaV beta3 Integrin 0.016 0.1 -10000 0 -0.5 8 8
PTK2 0.016 0.072 -10000 0 -0.42 2 2
positive regulation of JNK cascade 0.018 0.079 -10000 0 -0.36 3 3
CDC42/GDP 0.038 0.12 0.33 2 -0.46 5 7
Rac1/GDP 0.021 0.11 -10000 0 -0.46 5 5
RAP1B 0.027 0.006 -10000 0 -10000 0 0
RAP1A 0.027 0.006 -10000 0 -10000 0 0
CTNNB1 0.027 0.006 -10000 0 -10000 0 0
CDC42/GTP 0.026 0.098 -10000 0 -0.44 3 3
nectin-3/I-afadin 0.033 0.053 -10000 0 -0.5 2 2
RAPGEF1 0.025 0.097 0.28 2 -0.46 2 4
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.014 0.097 -10000 0 -0.46 4 4
PDGFB-D/PDGFRB -0.002 0.14 -10000 0 -0.66 9 9
TLN1 0 0.036 -10000 0 -0.47 1 1
Rap1/GTP 0.016 0.067 -10000 0 -0.34 2 2
IQGAP1 0.027 0.004 -10000 0 -10000 0 0
Rap1/GTP/I-afadin 0.048 0.017 -10000 0 -10000 0 0
nectin-3(dimer)/I-afadin/I-afadin/nectin-3(dimer)/I-afadin/I-afadin 0.033 0.053 -10000 0 -0.5 2 2
PVR 0.027 0.008 -10000 0 -10000 0 0
Necl-5(dimer) 0.027 0.008 -10000 0 -10000 0 0
mol:GDP 0.027 0.13 0.36 2 -0.58 5 7
MLLT4 0.027 0.005 -10000 0 -10000 0 0
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
PI3K 0.053 0.099 -10000 0 -0.38 10 10
nectin-1(dimer)/I-afadin/I-afadin/nectin-1(dimer)/I-afadin/I-afadin 0.039 0.01 -10000 0 -10000 0 0
positive regulation of lamellipodium assembly 0.007 0.092 -10000 0 -0.36 7 7
PVRL1 0.027 0.009 -10000 0 -10000 0 0
PVRL3 0.02 0.067 -10000 0 -0.66 2 2
PVRL2 0.028 0.003 -10000 0 -10000 0 0
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
CDH1 -0.026 0.18 -10000 0 -0.66 16 16
CLDN1 -0.007 0.047 -10000 0 -10000 0 0
JAM-A/CLDN1 0.053 0.051 -10000 0 -0.41 2 2
SRC 0.019 0.1 -10000 0 -0.5 4 4
ITGB3 -0.002 0.13 -10000 0 -0.66 8 8
nectin-1(dimer)/I-afadin/I-afadin 0.039 0.01 -10000 0 -10000 0 0
FARP2 0.022 0.13 -10000 0 -0.56 5 5
RAC1 0.022 0.011 -10000 0 -10000 0 0
CTNNA1 0.027 0.005 -10000 0 -10000 0 0
nectin-3(dimer)/I-afadin/I-afadin/Necl-5(dimer) 0.047 0.049 -10000 0 -0.42 2 2
nectin-1/I-afadin 0.039 0.01 -10000 0 -10000 0 0
nectin-2/I-afadin 0.04 0.009 -10000 0 -10000 0 0
RAC1/GTP/IQGAP1/filamentous actin 0.029 0.016 -10000 0 -10000 0 0
nectin-1(dimer)/I-afadin/I-afadin/nectin-3(dimer/I-afadin/I-afadin 0.047 0.049 -10000 0 -0.42 2 2
CDC42/GTP/IQGAP1/filamentous actin 0.035 0.011 -10000 0 -10000 0 0
F11R 0.027 0.006 -10000 0 -10000 0 0
positive regulation of filopodium formation 0.018 0.079 -10000 0 -0.36 3 3
alphaV/beta3 Integrin/Talin 0.009 0.084 -10000 0 -0.34 7 7
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.04 0.009 -10000 0 -10000 0 0
nectin-2(dimer)/I-afadin/I-afadin 0.04 0.009 -10000 0 -10000 0 0
PIP5K1C 0.004 0.038 -10000 0 -0.36 2 2
VAV2 0.014 0.16 -10000 0 -0.62 7 7
RAP1/GDP 0.036 0.1 -10000 0 -0.4 5 5
ITGAV 0.028 0.003 -10000 0 -10000 0 0
nectin-3(dimer)/I-afadin/I-afadin/nectin-2(dimer)/I-afadin/I-afadin 0.048 0.049 -10000 0 -0.42 2 2
nectin-3(dimer)/I-afadin/I-afadin 0.033 0.053 -10000 0 -0.5 2 2
Rac1/GTP 0.01 0.11 -10000 0 -0.44 7 7
PTPRM 0.009 0.042 -10000 0 -0.39 2 2
E-cadherin/beta catenin/alpha catenin 0.037 0.12 -10000 0 -0.37 16 16
adherens junction assembly 0 0 -10000 0 -10000 0 0
CDC42 0.026 0.008 -10000 0 -10000 0 0
HIF-2-alpha transcription factor network

Figure S93.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S93.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MMP14 0.009 0.15 -10000 0 -0.62 4 4
oxygen homeostasis 0.005 0.009 -10000 0 -10000 0 0
TCEB2 0.025 0.011 -10000 0 -10000 0 0
TCEB1 0.027 0.005 -10000 0 -10000 0 0
VHL/Elongin B/Elongin C/HIF2A 0.06 0.075 -10000 0 -0.39 1 1
EPO 0.052 0.13 -10000 0 -0.57 2 2
FIH (dimer) 0.031 0.017 -10000 0 -10000 0 0
APEX1 0.026 0.024 -10000 0 -10000 0 0
SERPINE1 0.034 0.19 -10000 0 -0.68 10 10
FLT1 -0.009 0.19 -10000 0 -0.89 5 5
ADORA2A 0.049 0.15 0.44 1 -0.64 3 4
germ cell development 0.056 0.15 -10000 0 -0.64 3 3
SLC11A2 0.061 0.15 -10000 0 -0.7 2 2
BHLHE40 0.06 0.15 -10000 0 -0.7 2 2
HIF1AN 0.031 0.017 -10000 0 -10000 0 0
HIF2A/ARNT/SIRT1 0.069 0.1 -10000 0 -0.41 2 2
ETS1 0.014 0.054 -10000 0 -10000 0 0
CITED2 0.031 0.1 -10000 0 -0.55 3 3
KDR -0.17 0.46 -10000 0 -1.2 36 36
PGK1 0.062 0.15 -10000 0 -0.66 3 3
SIRT1 0.028 0.003 -10000 0 -10000 0 0
response to hypoxia 0 0 -10000 0 -10000 0 0
HIF2A/ARNT 0.094 0.18 -10000 0 -0.78 3 3
EPAS1 0.037 0.064 -10000 0 -0.43 1 1
SP1 0.029 0.013 -10000 0 -10000 0 0
ABCG2 0.058 0.16 -10000 0 -0.68 4 4
EFNA1 0.06 0.15 -10000 0 -0.66 3 3
FXN 0.051 0.15 0.44 1 -0.64 3 4
POU5F1 0.056 0.16 -10000 0 -0.67 3 3
neuron apoptosis -0.092 0.18 0.75 3 -10000 0 3
EP300 0.025 0.009 -10000 0 -10000 0 0
EGLN3 0.026 0.023 -10000 0 -10000 0 0
EGLN2 0.031 0.017 -10000 0 -10000 0 0
EGLN1 0.03 0.018 -10000 0 -10000 0 0
VHL/Elongin B/Elongin C 0.049 0.02 -10000 0 -10000 0 0
VHL 0.027 0.006 -10000 0 -10000 0 0
ARNT 0.027 0.023 -10000 0 -10000 0 0
SLC2A1 0.05 0.14 -10000 0 -0.64 3 3
TWIST1 0.042 0.13 0.44 1 -0.65 2 3
ELK1 0.033 0.003 -10000 0 -10000 0 0
HIF2A/ARNT/Cbp/p300 0.065 0.11 -10000 0 -0.48 1 1
VEGFA 0.06 0.15 -10000 0 -0.66 3 3
CREBBP 0.025 0.008 -10000 0 -10000 0 0
Role of Calcineurin-dependent NFAT signaling in lymphocytes

Figure S94.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S94.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.027 0.006 -10000 0 -10000 0 0
NFATC1 0.017 0.11 0.37 4 -0.41 3 7
NFATC2 -0.036 0.096 0.19 2 -0.29 16 18
NFATC3 0.013 0.011 -10000 0 -10000 0 0
YWHAE 0.026 0.008 -10000 0 -10000 0 0
Calcineurin A alpha-beta B1/CABIN1 0.013 0.073 0.28 3 -0.32 1 4
Exportin 1/Ran/NUP214 0.047 0.018 -10000 0 -10000 0 0
mol:DAG -0.003 0.004 -10000 0 -10000 0 0
CABIN1/MEF2D/CaM/Ca2+/CAMK IV 0.019 0.07 -10000 0 -0.31 1 1
BCL2/BAX 0.038 0.013 -10000 0 -10000 0 0
CaM/Ca2+/Calcineurin A alpha-beta B1 0.002 0.024 -10000 0 -10000 0 0
CaM/Ca2+ 0.002 0.024 -10000 0 -10000 0 0
BAX 0.027 0.008 -10000 0 -10000 0 0
MAPK14 0.024 0.008 -10000 0 -10000 0 0
BAD 0.028 0.002 -10000 0 -10000 0 0
CABIN1/MEF2D 0.022 0.07 0.28 1 -0.32 1 2
Calcineurin A alpha-beta B1/BCL2 0.026 0.008 -10000 0 -10000 0 0
FKBP8 0.028 0.003 -10000 0 -10000 0 0
activation-induced cell death of T cells -0.021 0.07 0.32 1 -0.28 1 2
KPNB1 0.026 0.008 -10000 0 -10000 0 0
KPNA2 0.026 0.008 -10000 0 -10000 0 0
XPO1 0.027 0.004 -10000 0 -10000 0 0
SFN -0.019 0.048 -10000 0 -10000 0 0
MAP3K8 0.022 0.013 -10000 0 -10000 0 0
NFAT4/CK1 alpha 0.005 0.034 -10000 0 -10000 0 0
MEF2D/NFAT1/Cbp/p300 -0.11 0.2 -10000 0 -0.36 71 71
CABIN1 0.013 0.073 0.28 3 -0.33 1 4
CALM1 0.02 0.015 -10000 0 -10000 0 0
RAN 0.026 0.006 -10000 0 -10000 0 0
MAP3K1 0.027 0.004 -10000 0 -10000 0 0
CAMK4 0.026 0.008 -10000 0 -10000 0 0
mol:Ca2+ -0.007 0.01 -10000 0 -10000 0 0
MAPK3 0.026 0.008 -10000 0 -10000 0 0
YWHAH 0.025 0.008 -10000 0 -10000 0 0
Calcineurin A alpha-beta B1/AKAP79/PKA 0.036 0.012 -10000 0 -10000 0 0
YWHAB 0.027 0.006 -10000 0 -10000 0 0
MAPK8 0.01 0.086 -10000 0 -0.58 4 4
MAPK9 0.027 0.005 -10000 0 -10000 0 0
YWHAG 0.023 0.011 -10000 0 -10000 0 0
FKBP1A 0.027 0.006 -10000 0 -10000 0 0
NFAT1-c-4/YWHAQ -0.002 0.12 0.3 4 -0.4 8 12
PRKCH 0.026 0.007 -10000 0 -10000 0 0
CABIN1/Cbp/p300 0.01 0.036 -10000 0 -10000 0 0
CASP3 0.022 0.013 -10000 0 -10000 0 0
PIM1 0.026 0.011 -10000 0 -10000 0 0
Calcineurin A alpha-beta B1/FKBP12/FK506 0.008 0.014 -10000 0 -10000 0 0
apoptosis 0.02 0.009 -10000 0 -10000 0 0
14-3-3 family/BAD/CaM/Ca2+/Calcineurin A alpha-beta B1 0.001 0.045 -10000 0 -0.26 1 1
PRKCB 0.024 0.014 -10000 0 -10000 0 0
PRKCE 0.027 0.004 -10000 0 -10000 0 0
JNK2/NFAT4 0.015 0.05 -10000 0 -10000 0 0
BAD/BCL-XL 0.039 0.01 -10000 0 -10000 0 0
PRKCD 0.027 0.006 -10000 0 -10000 0 0
NUP214 0.026 0.007 -10000 0 -10000 0 0
PRKCZ 0.02 0.014 -10000 0 -10000 0 0
PRKCA 0.026 0.008 -10000 0 -10000 0 0
PRKCG -0.009 0.041 -10000 0 -10000 0 0
PRKCQ 0.018 0.081 -10000 0 -0.66 3 3
FKBP38/BCL2 0.038 0.012 -10000 0 -10000 0 0
EP300 0.006 0.027 -10000 0 -10000 0 0
PRKCB1 0 0 -10000 0 -10000 0 0
CSNK2A1 0.027 0.006 -10000 0 -10000 0 0
NFATc/JNK1 0.021 0.12 0.36 4 -0.4 5 9
CaM/Ca2+/FKBP38 0.013 0.03 -10000 0 -10000 0 0
FKBP12/FK506 0.02 0.005 -10000 0 -10000 0 0
CSNK1A1 -0.003 0.022 -10000 0 -10000 0 0
CaM/Ca2+/CAMK IV 0.013 0.03 -10000 0 -10000 0 0
NFATc/ERK1 0.019 0.094 0.33 1 -0.39 3 4
CABIN1/YWHAQ/CaM/Ca2+/CAMK IV 0.029 0.068 -10000 0 -10000 0 0
NR4A1 -0.24 0.32 0.26 1 -0.61 86 87
GSK3B 0.022 0.012 -10000 0 -10000 0 0
positive T cell selection 0.013 0.011 -10000 0 -10000 0 0
NFAT1/CK1 alpha -0.032 0.076 -10000 0 -0.31 5 5
RCH1/ KPNB1 0.038 0.012 -10000 0 -10000 0 0
YWHAQ 0.027 0.005 -10000 0 -10000 0 0
PRKACA 0.025 0.006 -10000 0 -10000 0 0
AKAP5 0.026 0.01 -10000 0 -10000 0 0
MEF2D 0.006 0.028 -10000 0 -10000 0 0
mol:FK506 0 0 -10000 0 -10000 0 0
YWHAZ 0.027 0.004 -10000 0 -10000 0 0
NFATc/p38 alpha 0.028 0.11 0.36 4 -0.39 3 7
CREBBP 0.007 0.026 -10000 0 -10000 0 0
BCL2 0.026 0.008 -10000 0 -10000 0 0
FAS signaling pathway (CD95)

Figure S95.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S95.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPTAN1 -0.007 0.028 0.21 1 -10000 0 1
RFC1 -0.007 0.021 -10000 0 -10000 0 0
PRKDC -0.006 0.035 0.22 2 -10000 0 2
RIPK1 0.027 0.007 -10000 0 -10000 0 0
CASP7 0.01 0.062 -10000 0 -0.56 2 2
FASLG/FAS/FADD/FAF1 0.004 0.035 -10000 0 -10000 0 0
MAP2K4 -0.006 0.11 0.33 1 -0.36 7 8
mol:ceramide 0.012 0.063 -10000 0 -10000 0 0
GSN -0.007 0.028 -10000 0 -10000 0 0
FASLG/FAS/FADD/FAF1/Caspase 8 0.007 0.044 -10000 0 -10000 0 0
FAS 0.024 0.016 -10000 0 -10000 0 0
BID -0.016 0.01 -10000 0 -10000 0 0
MAP3K1 0.005 0.076 0.31 1 -0.4 2 3
MAP3K7 0.027 0.006 -10000 0 -10000 0 0
RB1 -0.006 0.032 0.22 2 -10000 0 2
CFLAR 0.028 0.005 -10000 0 -10000 0 0
HGF/MET 0.018 0.096 -10000 0 -0.41 9 9
ARHGDIB -0.001 0.048 0.22 7 -10000 0 7
FADD 0.024 0.016 -10000 0 -10000 0 0
actin filament polymerization 0.007 0.03 -10000 0 -0.21 1 1
NFKB1 -0.009 0.13 -10000 0 -0.63 7 7
MAPK8 -0.03 0.17 0.31 1 -0.47 23 24
DFFA -0.007 0.021 -10000 0 -10000 0 0
DNA fragmentation during apoptosis -0.007 0.024 -10000 0 -10000 0 0
FAS/FADD/MET 0.034 0.035 -10000 0 -10000 0 0
CFLAR/RIP1 0.04 0.012 -10000 0 -10000 0 0
FAIM3 0.021 0.025 -10000 0 -10000 0 0
FAF1 0.022 0.018 -10000 0 -10000 0 0
PARP1 -0.009 0.027 -10000 0 -10000 0 0
DFFB -0.007 0.021 -10000 0 -10000 0 0
CHUK -0.014 0.12 -10000 0 -0.58 7 7
FASLG 0.013 0.033 -10000 0 -10000 0 0
FAS/FADD 0.035 0.023 -10000 0 -10000 0 0
HGF -0.007 0.14 -10000 0 -0.66 9 9
LMNA -0.009 0.019 -10000 0 -10000 0 0
CASP6 -0.006 0.018 -10000 0 -10000 0 0
CASP10 0.023 0.016 -10000 0 -10000 0 0
CASP3 -0.002 0.006 -10000 0 -10000 0 0
PTPN13 0.027 0.006 -10000 0 -10000 0 0
CASP8 -0.017 0.014 -10000 0 -10000 0 0
IL6 -0.11 0.39 -10000 0 -1.2 24 24
MET 0.017 0.024 -10000 0 -10000 0 0
ICAD/CAD -0.006 0.005 -10000 0 -10000 0 0
FASLG/FAS/FADD/FAF1/Caspase 10 0.013 0.063 -10000 0 -10000 0 0
activation of caspase activity by cytochrome c -0.016 0.01 -10000 0 -10000 0 0
PAK2 -0.003 0.044 0.22 5 -10000 0 5
BCL2 0.026 0.008 -10000 0 -10000 0 0
Class I PI3K signaling events

Figure S96.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S96.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ARF5/GTP -0.016 0.046 -10000 0 -10000 0 0
DAPP1 0.001 0.12 0.29 4 -0.56 5 9
Src family/SYK family/BLNK-LAT/BTK-ITK -0.02 0.15 -10000 0 -0.54 11 11
mol:DAG 0.006 0.098 0.4 7 -0.32 1 8
HRAS 0.028 0.009 -10000 0 -10000 0 0
RAP1A 0.027 0.01 -10000 0 -10000 0 0
ARF5/GDP 0.017 0.067 0.24 1 -0.29 5 6
PLCG2 -0.007 0.14 -10000 0 -0.66 10 10
PLCG1 0.027 0.006 -10000 0 -10000 0 0
ARF5 0.022 0.011 -10000 0 -10000 0 0
mol:GTP -0.015 0.051 -10000 0 -0.34 3 3
ARF1/GTP 0.012 0.061 0.23 2 -0.33 2 4
RHOA 0.027 0.006 -10000 0 -10000 0 0
YES1 0.026 0.008 -10000 0 -10000 0 0
RAP1A/GTP -0.015 0.052 -10000 0 -0.33 3 3
ADAP1 -0.014 0.05 0.28 1 -10000 0 1
ARAP3 -0.015 0.051 -10000 0 -0.34 3 3
INPPL1 0.028 0.003 -10000 0 -10000 0 0
PREX1 0.02 0.067 -10000 0 -0.66 2 2
ARHGEF6 0.028 0 -10000 0 -10000 0 0
ARHGEF7 0.027 0.006 -10000 0 -10000 0 0
ARF1 0.027 0.006 -10000 0 -10000 0 0
NRAS 0.027 0.011 -10000 0 -10000 0 0
FYN 0.027 0.005 -10000 0 -10000 0 0
ARF6 0.026 0.007 -10000 0 -10000 0 0
FGR 0.02 0.05 -10000 0 -0.66 1 1
mol:Ca2+ 0.006 0.064 0.26 8 -10000 0 8
mol:IP4 0 0 -10000 0 -10000 0 0
TIAM1 0.026 0.008 -10000 0 -10000 0 0
ZAP70 0.016 0.033 -10000 0 -10000 0 0
mol:IP3 0 0.066 0.26 7 -0.21 1 8
LYN 0.027 0.005 -10000 0 -10000 0 0
ARF1/GDP 0.025 0.073 0.24 1 -0.28 5 6
RhoA/GDP 0.036 0.063 0.27 1 -0.32 1 2
PDK1/Src/Hsp90 0.046 0.023 -10000 0 -10000 0 0
BLNK -0.001 0.14 -10000 0 -0.66 9 9
actin cytoskeleton reorganization 0.024 0.1 0.32 9 -0.41 2 11
SRC 0.026 0.009 -10000 0 -10000 0 0
PLEKHA2 -0.01 0.006 -10000 0 -10000 0 0
RAC1 0.022 0.011 -10000 0 -10000 0 0
PTEN 0.026 0.013 -10000 0 -10000 0 0
HSP90AA1 0.026 0.008 -10000 0 -10000 0 0
ARF6/GTP -0.018 0.049 -10000 0 -10000 0 0
RhoA/GTP -0.017 0.047 -10000 0 -0.32 3 3
Src family/SYK family/BLNK-LAT 0.002 0.082 -10000 0 -0.39 2 2
BLK 0.017 0.025 -10000 0 -10000 0 0
PDPK1 0.025 0.008 -10000 0 -10000 0 0
CYTH1 -0.016 0.042 -10000 0 -0.32 2 2
HCK 0.012 0.056 -10000 0 -0.66 1 1
CYTH3 -0.014 0.05 0.28 1 -10000 0 1
CYTH2 -0.013 0.058 0.28 2 -0.32 3 5
KRAS 0.026 0.01 -10000 0 -10000 0 0
GO:0030676 0 0 -10000 0 -10000 0 0
FOXO3 0.01 0.04 -10000 0 -10000 0 0
SGK1 0.011 0.053 -10000 0 -10000 0 0
INPP5D 0.024 0.017 -10000 0 -10000 0 0
mol:GDP 0.014 0.075 0.25 2 -0.3 5 7
SOS1 0.027 0.004 -10000 0 -10000 0 0
SYK 0.023 0.047 -10000 0 -0.66 1 1
ARF6/GDP 0.028 0.066 0.28 3 -10000 0 3
mol:PI-3-4-5-P3 -0.014 0.051 -10000 0 -0.33 3 3
ARAP3/RAP1A/GTP -0.015 0.053 -10000 0 -0.34 3 3
VAV1 0.007 0.06 -10000 0 -0.66 1 1
mol:PI-3-4-P2 0.011 0.011 -10000 0 -10000 0 0
RAS family/GTP/PI3K Class I 0.035 0.052 -10000 0 -0.34 3 3
PLEKHA1 -0.01 0.006 -10000 0 -10000 0 0
Rac1/GDP 0.017 0.067 0.24 1 -0.29 5 6
LAT 0.017 0.028 -10000 0 -10000 0 0
Rac1/GTP 0.02 0.068 -10000 0 -0.57 1 1
ITK -0.018 0.048 -10000 0 -10000 0 0
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma -0.007 0.096 0.43 3 -0.34 4 7
LCK 0.024 0.017 -10000 0 -10000 0 0
BTK -0.019 0.059 0.28 2 -0.32 3 5
VEGFR1 specific signals

Figure S97.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S97.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR1 homodimer/VEGFB homodimer 0.024 0.082 -10000 0 -0.8 2 2
VEGFR1 homodimer/NRP1 0.005 0.079 -10000 0 -0.8 2 2
mol:DAG 0.005 0.074 -10000 0 -0.74 2 2
VEGFR1 homodimer/NRP1/VEGFR 121 0.02 0.077 -10000 0 -0.75 2 2
CaM/Ca2+ 0.02 0.073 -10000 0 -0.71 2 2
HIF1A 0.028 0.04 -10000 0 -0.38 2 2
GAB1 0.027 0.007 -10000 0 -10000 0 0
AKT1 0.004 0.067 -10000 0 -0.67 2 2
PLCG1 0.005 0.074 -10000 0 -0.75 2 2
NOS3 0.012 0.089 -10000 0 -0.43 7 7
CBL 0.027 0.005 -10000 0 -10000 0 0
mol:NO 0.021 0.1 0.41 2 -0.41 8 10
FLT1 0.009 0.089 -10000 0 -0.9 2 2
PGF 0.024 0.015 -10000 0 -10000 0 0
VEGFR1 homodimer/NRP2/VEGFR121 0.033 0.085 -10000 0 -0.63 3 3
CALM1 0.026 0.007 -10000 0 -10000 0 0
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
eNOS/Hsp90 0.04 0.1 0.33 3 -0.51 3 6
endothelial cell proliferation 0.004 0.076 -10000 0 -0.71 2 2
mol:Ca2+ 0.005 0.073 -10000 0 -0.73 2 2
MAPK3 -0.014 0.065 -10000 0 -0.67 2 2
MAPK1 -0.014 0.065 -10000 0 -0.67 2 2
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
PLGF homodimer 0.024 0.015 -10000 0 -10000 0 0
PRKACA 0.028 0.002 -10000 0 -10000 0 0
RP11-342D11.1 0 0 -10000 0 -10000 0 0
CAV1 0.022 0.013 -10000 0 -10000 0 0
VEGFA homodimer 0.026 0.009 -10000 0 -10000 0 0
VEGFR1 homodimer/VEGFA homodimer 0.023 0.082 -10000 0 -0.8 2 2
platelet activating factor biosynthetic process -0.015 0.063 -10000 0 -0.65 2 2
PI3K 0.05 0.079 -10000 0 -0.72 2 2
PRKCA -0.014 0.067 -10000 0 -0.7 2 2
PRKCB -0.015 0.067 -10000 0 -0.7 2 2
VEGFR1 homodimer/PLGF homodimer 0.023 0.082 -10000 0 -0.8 2 2
VEGFA 0.026 0.009 -10000 0 -10000 0 0
VEGFB 0.028 0.002 -10000 0 -10000 0 0
mol:IP3 0.005 0.074 -10000 0 -0.74 2 2
RASA1 0.008 0.076 -10000 0 -0.75 2 2
NRP2 0.023 0.048 -10000 0 -0.66 1 1
VEGFR1 homodimer 0.009 0.088 -10000 0 -0.89 2 2
VEGFB homodimer 0.028 0.002 -10000 0 -10000 0 0
NCK1 0.027 0.006 -10000 0 -10000 0 0
eNOS/Caveolin-1 0.012 0.097 0.4 1 -0.46 3 4
PTPN11 0.027 0.006 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 0.048 0.077 -10000 0 -0.71 2 2
mol:L-citrulline 0.021 0.1 0.41 2 -0.41 8 10
VEGFR1 homodimer/VEGFA homodimer/CBL/CD2AP 0.049 0.079 -10000 0 -0.72 2 2
VEGFR1 homodimer/VEGFA homodimer/NCK1 0.035 0.079 -10000 0 -0.75 2 2
CD2AP 0.026 0.007 -10000 0 -10000 0 0
PI3K/GAB1 0.06 0.079 -10000 0 -0.69 2 2
PDPK1 0.007 0.07 -10000 0 -0.68 2 2
VEGFR1 homodimer/VEGFA homodimer/SHP2 0.035 0.08 -10000 0 -0.76 2 2
mol:NADP 0.021 0.1 0.41 2 -0.41 8 10
HSP90AA1 0.026 0.008 -10000 0 -10000 0 0
ubiquitin-dependent protein catabolic process 0.047 0.077 -10000 0 -0.71 2 2
VEGFR1 homodimer/NRP2 0.021 0.088 -10000 0 -0.68 3 3
FOXM1 transcription factor network

Figure S98.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S98.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC3 0.038 0.24 -9999 0 -0.89 1 1
PLK1 0.026 0.052 -9999 0 -10000 0 0
BIRC5 0.014 0.054 -9999 0 -10000 0 0
HSPA1B 0.027 0.25 -9999 0 -0.99 1 1
MAP2K1 0.029 0.039 -9999 0 -10000 0 0
BRCA2 0.029 0.25 -9999 0 -0.99 1 1
FOXM1 0.026 0.27 -9999 0 -1.2 1 1
XRCC1 0.027 0.25 -9999 0 -0.99 1 1
FOXM1B/p19 0.021 0.26 -9999 0 -1.1 1 1
Cyclin D1/CDK4 0.043 0.24 -9999 0 -0.91 2 2
CDC2 0.028 0.26 -9999 0 -1 1 1
TGFA 0.032 0.24 -9999 0 -0.89 2 2
SKP2 0.03 0.24 -9999 0 -0.99 1 1
CCNE1 0.022 0.03 -9999 0 -10000 0 0
CKS1B 0.03 0.25 -9999 0 -0.99 1 1
RB1 0.043 0.17 -9999 0 -0.74 3 3
FOXM1C/SP1 0.036 0.26 -9999 0 -0.97 1 1
AURKB -0.018 0.18 -9999 0 -0.88 8 8
CENPF 0.026 0.25 -9999 0 -0.99 1 1
CDK4 0.028 0.018 -9999 0 -10000 0 0
MYC 0.036 0.23 -9999 0 -0.68 1 1
CHEK2 0.025 0.042 -9999 0 -10000 0 0
ONECUT1 0.034 0.24 -9999 0 -0.95 1 1
CDKN2A -0.049 0.04 -9999 0 -10000 0 0
LAMA4 0.026 0.25 -9999 0 -0.99 1 1
FOXM1B/HNF6 0.031 0.26 -9999 0 -1.1 1 1
FOS -0.092 0.48 -9999 0 -1.1 33 33
SP1 0.028 0.006 -9999 0 -10000 0 0
CDC25B 0.036 0.24 -9999 0 -0.89 1 1
response to radiation 0.009 0.021 -9999 0 -10000 0 0
CENPB 0.036 0.24 -9999 0 -0.89 1 1
CENPA 0.023 0.25 -9999 0 -0.99 1 1
NEK2 0.025 0.25 -9999 0 -0.99 1 1
HIST1H2BA 0.023 0.25 -9999 0 -1 1 1
CCNA2 0.014 0.038 -9999 0 -10000 0 0
EP300 0.025 0.009 -9999 0 -10000 0 0
CCNB1/CDK1 0.024 0.26 -9999 0 -1.1 1 1
CCNB2 0.021 0.25 -9999 0 -0.99 1 1
CCNB1 0.029 0.25 -9999 0 -1 1 1
ETV5 0.032 0.25 -9999 0 -0.89 1 1
ESR1 -0.016 0.36 -9999 0 -1.1 13 13
CCND1 0.036 0.24 -9999 0 -0.99 2 2
GSK3A 0.028 0.035 -9999 0 -10000 0 0
Cyclin A-E1/CDK1-2 0.047 0.056 -9999 0 -10000 0 0
CDK2 0.029 0.01 -9999 0 -10000 0 0
G2/M transition of mitotic cell cycle 0.009 0.025 -9999 0 -10000 0 0
FOXM1B/Cbp/p300 0.04 0.24 -9999 0 -0.94 1 1
GAS1 -0.009 0.34 -9999 0 -1.1 11 11
MMP2 0.037 0.25 -9999 0 -1.1 1 1
RB1/FOXM1C 0.037 0.24 -9999 0 -0.9 2 2
CREBBP 0.025 0.008 -9999 0 -10000 0 0
Aurora B signaling

Figure S99.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S99.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Condensin I complex -0.001 0.059 -10000 0 -0.23 2 2
STMN1 -0.009 0.029 -10000 0 -10000 0 0
Aurora B/RasGAP/Survivin 0.007 0.06 -10000 0 -10000 0 0
Chromosomal passenger complex/Cul3 protein complex -0.026 0.093 -10000 0 -0.29 18 18
BIRC5 -0.012 0.048 -10000 0 -10000 0 0
DES -0.24 0.31 -10000 0 -0.59 90 90
Aurora C/Aurora B/INCENP 0.037 0.035 -10000 0 -10000 0 0
Aurora B/TACC1 0.007 0.037 -10000 0 -10000 0 0
Aurora B/PP2A 0.004 0.043 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
CBX5 0.005 0.006 -10000 0 -10000 0 0
mitotic metaphase/anaphase transition 0 0.002 -10000 0 -10000 0 0
NDC80 -0.012 0.035 -10000 0 -10000 0 0
Cul3 protein complex 0.014 0.13 -10000 0 -0.43 16 16
KIF2C -0.003 0.052 -10000 0 -0.33 4 4
PEBP1 0.027 0.006 -10000 0 -10000 0 0
KIF20A -0.006 0.047 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
Aurora B/RasGAP 0.005 0.043 -10000 0 -10000 0 0
SEPT1 0.024 0.016 -10000 0 -10000 0 0
SMC2 0.027 0.007 -10000 0 -10000 0 0
SMC4 0.027 0.005 -10000 0 -10000 0 0
NSUN2/NPM1/Nucleolin -0.011 0.11 -10000 0 -0.52 8 8
PSMA3 0.026 0.007 -10000 0 -10000 0 0
G2/M transition of mitotic cell cycle -0.001 0.002 -10000 0 -10000 0 0
H3F3B 0.002 0.016 -10000 0 -10000 0 0
AURKB -0.012 0.05 -10000 0 -10000 0 0
AURKC 0.028 0.003 -10000 0 -10000 0 0
CDCA8 0.017 0.033 -10000 0 -10000 0 0
cytokinesis -0.033 0.083 0.23 1 -0.46 3 4
Aurora B/Septin1 -0.002 0.086 -10000 0 -0.43 3 3
AURKA 0.025 0.014 -10000 0 -10000 0 0
INCENP 0.029 0.006 -10000 0 -10000 0 0
KLHL13 -0.024 0.18 -10000 0 -0.66 16 16
BUB1 -0.01 0.048 -10000 0 -10000 0 0
hSgo1/Aurora B/Survivin 0.008 0.059 -10000 0 -10000 0 0
EVI5 0.027 0.007 -10000 0 -10000 0 0
RhoA/GTP 0.03 0.063 -10000 0 -10000 0 0
SGOL1 0.017 0.029 -10000 0 -10000 0 0
CENPA 0 0.056 -10000 0 -0.23 7 7
NCAPG 0.002 0.043 -10000 0 -10000 0 0
Aurora B/HC8 Proteasome 0.004 0.042 -10000 0 -10000 0 0
NCAPD2 0.027 0.007 -10000 0 -10000 0 0
Aurora B/PP1-gamma 0.004 0.043 -10000 0 -10000 0 0
RHOA 0.027 0.006 -10000 0 -10000 0 0
NCAPH 0.008 0.04 -10000 0 -10000 0 0
NPM1 -0.006 0.062 -10000 0 -0.3 7 7
RASA1 0.027 0.005 -10000 0 -10000 0 0
KLHL9 0.024 0.026 -10000 0 -0.34 1 1
mitotic prometaphase 0 0.004 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.004 0.042 -10000 0 -10000 0 0
PPP1CC 0.027 0.006 -10000 0 -10000 0 0
Centraspindlin 0.021 0.065 -10000 0 -10000 0 0
RhoA/GDP 0.02 0.005 -10000 0 -10000 0 0
NSUN2 -0.005 0.06 -10000 0 -0.3 7 7
MYLK -0.01 0.071 -10000 0 -0.38 7 7
KIF23 0.028 0.009 -10000 0 -10000 0 0
VIM -0.01 0.03 -10000 0 -10000 0 0
RACGAP1 0.027 0.006 -10000 0 -10000 0 0
mitosis 0 0 -10000 0 -10000 0 0
NCL -0.011 0.082 -10000 0 -0.36 8 8
Chromosomal passenger complex -0.005 0.045 -10000 0 -10000 0 0
Chromosomal passenger complex/EVI5 0.049 0.08 -10000 0 -10000 0 0
TACC1 0.027 0.006 -10000 0 -10000 0 0
PPP2R5D 0.027 0.007 -10000 0 -10000 0 0
CUL3 0.027 0.005 -10000 0 -10000 0 0
response to DNA damage stimulus 0 0 -10000 0 -10000 0 0
Signaling events mediated by HDAC Class II

Figure S100.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S100.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
G beta1gamma2/HDAC5 0.059 0.029 -9999 0 -10000 0 0
HDAC3 0.027 0.005 -9999 0 -10000 0 0
Ran/GTP/Exportin 1/HDAC4 -0.009 0.01 -9999 0 -10000 0 0
GATA1/HDAC4 0.032 0.029 -9999 0 -0.24 1 1
GATA1/HDAC5 0.032 0.023 -9999 0 -10000 0 0
GATA2/HDAC5 -0.044 0.19 -9999 0 -0.47 34 34
HDAC5/BCL6/BCoR 0.051 0.019 -9999 0 -10000 0 0
HDAC9 0.022 0.011 -9999 0 -10000 0 0
Glucocorticoid receptor/Hsp90/HDAC6 0.051 0.018 -9999 0 -10000 0 0
HDAC4/ANKRA2 0.038 0.021 -9999 0 -0.24 1 1
HDAC5/YWHAB 0.037 0.013 -9999 0 -10000 0 0
NPC/RanGAP1/SUMO1/Ubc9 0.013 0.006 -9999 0 -10000 0 0
GATA2 -0.083 0.25 -9999 0 -0.66 34 34
HDAC4/RFXANK 0.039 0.021 -9999 0 -0.24 1 1
BCOR 0.028 0.003 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
HDAC10 0.025 0.009 -9999 0 -10000 0 0
HDAC5 0.026 0.008 -9999 0 -10000 0 0
GNB1/GNG2 0.037 0.014 -9999 0 -10000 0 0
Histones 0.027 0.047 -9999 0 -10000 0 0
ADRBK1 0.028 0.002 -9999 0 -10000 0 0
HDAC4 0.025 0.026 -9999 0 -0.34 1 1
XPO1 0.028 0.004 -9999 0 -10000 0 0
HDAC5/ANKRA2 0.038 0.013 -9999 0 -10000 0 0
HDAC4/Ubc9 0.035 0.023 -9999 0 -0.24 1 1
HDAC7 0.027 0.006 -9999 0 -10000 0 0
HDAC5/14-3-3 E 0.037 0.013 -9999 0 -10000 0 0
TUBA1B 0.027 0.005 -9999 0 -10000 0 0
HDAC6 0.028 0.003 -9999 0 -10000 0 0
HDAC5/RFXANK 0.038 0.012 -9999 0 -10000 0 0
CAMK4 0.026 0.008 -9999 0 -10000 0 0
Tubulin/HDAC6 0.052 0.017 -9999 0 -10000 0 0
SUMO1 0.028 0.004 -9999 0 -10000 0 0
EntrezGene:9972 0 0 -9999 0 -10000 0 0
YWHAB 0.027 0.006 -9999 0 -10000 0 0
GATA1 0.014 0.028 -9999 0 -10000 0 0
EntrezGene:8021 0 0 -9999 0 -10000 0 0
YWHAE 0.026 0.008 -9999 0 -10000 0 0
NR3C1 0.027 0.005 -9999 0 -10000 0 0
SUMO1/HDAC4 0.037 0.043 -9999 0 -10000 0 0
SRF 0.027 0.007 -9999 0 -10000 0 0
HDAC4/YWHAB 0.037 0.022 -9999 0 -0.24 1 1
Tubulin 0.038 0.012 -9999 0 -10000 0 0
HDAC4/14-3-3 E 0.036 0.023 -9999 0 -0.24 1 1
GNB1 0.025 0.008 -9999 0 -10000 0 0
RANGAP1 0.025 0.008 -9999 0 -10000 0 0
BCL6/BCoR 0.039 0.011 -9999 0 -10000 0 0
HDAC4/HDAC3/SMRT (N-CoR2) 0.05 0.024 -9999 0 -10000 0 0
HDAC4/SRF 0.05 0.025 -9999 0 -10000 0 0
HDAC4/ER alpha 0.012 0.11 -9999 0 -0.42 13 13
EntrezGene:23225 0 0 -9999 0 -10000 0 0
positive regulation of chromatin silencing 0.027 0.047 -9999 0 -10000 0 0
cell motility 0.051 0.017 -9999 0 -10000 0 0
EntrezGene:23636 0 0 -9999 0 -10000 0 0
UBE2I 0.025 0.008 -9999 0 -10000 0 0
HDAC7/HDAC3 0.039 0.01 -9999 0 -10000 0 0
BCL6 0.027 0.009 -9999 0 -10000 0 0
HDAC4/CaMK II delta B 0.025 0.026 -9999 0 -0.34 1 1
Hsp90/HDAC6 0.038 0.012 -9999 0 -10000 0 0
ESR1 -0.007 0.14 -9999 0 -0.58 12 12
HDAC6/HDAC11 0.039 0.01 -9999 0 -10000 0 0
Ran/GTP/Exportin 1 0.035 0.04 -9999 0 -10000 0 0
NPC 0.016 0.002 -9999 0 -10000 0 0
MEF2C 0.027 0.005 -9999 0 -10000 0 0
RAN 0.027 0.006 -9999 0 -10000 0 0
HDAC4/MEF2C 0.069 0.035 -9999 0 -10000 0 0
GNG2 0.026 0.007 -9999 0 -10000 0 0
NCOR2 0.027 0.006 -9999 0 -10000 0 0
TUBB2A 0.027 0.006 -9999 0 -10000 0 0
HDAC11 0.027 0.006 -9999 0 -10000 0 0
HSP90AA1 0.026 0.008 -9999 0 -10000 0 0
RANBP2 0.028 0.003 -9999 0 -10000 0 0
ANKRA2 0.027 0.004 -9999 0 -10000 0 0
RFXANK 0.028 0.003 -9999 0 -10000 0 0
nuclear import -0.031 0.022 -9999 0 -10000 0 0
Hedgehog signaling events mediated by Gli proteins

Figure S101.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S101.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.026 0.007 -10000 0 -10000 0 0
HDAC2 0.027 0.005 -10000 0 -10000 0 0
GNB1/GNG2 0.036 0.046 -10000 0 -0.43 1 1
forebrain development 0.05 0.14 0.48 6 -0.54 3 9
GNAO1 -0.011 0.15 -10000 0 -0.66 11 11
SMO/beta Arrestin2 0.027 0.054 -10000 0 -0.48 2 2
SMO 0.017 0.067 -10000 0 -0.66 2 2
ARRB2 0.026 0.01 -10000 0 -10000 0 0
GLI3/SPOP 0.029 0.064 0.24 1 -0.31 2 3
mol:GTP 0 0 -10000 0 -10000 0 0
GSK3B 0.027 0.006 -10000 0 -10000 0 0
GNAI2 0.027 0.007 -10000 0 -10000 0 0
SIN3/HDAC complex 0.065 0.021 -10000 0 -10000 0 0
GNAI1 0.02 0.048 -10000 0 -0.66 1 1
XPO1 0.029 0.004 -10000 0 -10000 0 0
GLI1/Su(fu) 0.012 0.1 -10000 0 -0.67 2 2
SAP30 0.026 0.01 -10000 0 -10000 0 0
mol:GDP 0.017 0.067 -10000 0 -0.66 2 2
MIM/GLI2A 0.024 0.049 -10000 0 -0.66 1 1
IFT88 0.027 0.006 -10000 0 -10000 0 0
GNAI3 0.027 0.006 -10000 0 -10000 0 0
GLI2 0.015 0.083 0.27 4 -0.41 2 6
GLI3 0.022 0.066 0.25 1 -0.31 3 4
CSNK1D 0.026 0.008 -10000 0 -10000 0 0
CSNK1E 0.025 0.008 -10000 0 -10000 0 0
SAP18 0.027 0.006 -10000 0 -10000 0 0
embryonic digit morphogenesis 0.027 0.006 -10000 0 -10000 0 0
GNG2 0.026 0.007 -10000 0 -10000 0 0
Gi family/GTP -0.006 0.083 -10000 0 -0.3 12 12
SIN3B 0.028 0.002 -10000 0 -10000 0 0
SIN3A 0.027 0.004 -10000 0 -10000 0 0
GLI3/Su(fu) 0.016 0.073 -10000 0 -0.39 1 1
GLI2/Su(fu) 0.013 0.067 0.24 1 -0.43 1 2
FOXA2 0.027 0.08 -10000 0 -0.58 3 3
neural tube patterning 0.05 0.14 0.48 6 -0.54 3 9
SPOP 0.026 0.008 -10000 0 -10000 0 0
Su(fu)/PIAS1 0.043 0.053 -10000 0 -10000 0 0
GNB1 0.025 0.008 -10000 0 -10000 0 0
CSNK1G2 0.028 0.003 -10000 0 -10000 0 0
CSNK1G3 0.027 0.005 -10000 0 -10000 0 0
MTSS1 0.024 0.049 -10000 0 -0.66 1 1
embryonic limb morphogenesis 0.05 0.14 0.48 6 -0.54 3 9
SUFU 0.017 0.027 -10000 0 -10000 0 0
LGALS3 0.021 0.049 -10000 0 -0.66 1 1
catabolic process 0.033 0.088 -10000 0 -0.37 1 1
GLI3A/CBP 0.028 0.041 -10000 0 -0.38 2 2
KIF3A 0.027 0.005 -10000 0 -10000 0 0
GLI1 0.05 0.14 0.49 6 -0.55 3 9
RAB23 0.027 0.006 -10000 0 -10000 0 0
CSNK1A1 0.027 0.005 -10000 0 -10000 0 0
IFT172 0.027 0.005 -10000 0 -10000 0 0
RBBP7 0.028 0.003 -10000 0 -10000 0 0
Su(fu)/Galectin3 0.04 0.059 -10000 0 -0.38 1 1
GNAZ 0.026 0.008 -10000 0 -10000 0 0
RBBP4 0.026 0.007 -10000 0 -10000 0 0
CSNK1G1 0.028 0.004 -10000 0 -10000 0 0
PIAS1 0.028 0.004 -10000 0 -10000 0 0
PRKACA 0.028 0.002 -10000 0 -10000 0 0
GLI2/SPOP 0.017 0.071 -10000 0 -0.39 2 2
STK36 0.029 0.005 -10000 0 -10000 0 0
Gi family/GNB1/GNG2/GDP -0.001 0.086 -10000 0 -0.48 4 4
PTCH1 0.047 0.12 0.56 3 -0.72 1 4
MIM/GLI1 0.057 0.13 0.47 4 -0.8 1 5
CREBBP 0.028 0.041 -10000 0 -0.37 2 2
Su(fu)/SIN3/HDAC complex 0.011 0.12 -10000 0 -0.5 8 8
Arf6 downstream pathway

Figure S102.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S102.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PLAUR 0.014 0.03 -10000 0 -10000 0 0
regulation of axonogenesis -0.001 0.05 -10000 0 -10000 0 0
myoblast fusion -0.021 0.037 0.37 1 -10000 0 1
mol:GTP 0.008 0.042 -10000 0 -10000 0 0
regulation of calcium-dependent cell-cell adhesion -0.042 0.04 -10000 0 -10000 0 0
ARF1/GTP 0.027 0.036 -10000 0 -10000 0 0
mol:GM1 0.001 0.03 -10000 0 -10000 0 0
mol:Choline 0.002 0.027 -10000 0 -10000 0 0
lamellipodium assembly -0.014 0.095 -10000 0 -0.36 14 14
MAPK3 0.014 0.029 -10000 0 -10000 0 0
ARF6/GTP/NME1/Tiam1 0.043 0.04 -10000 0 -10000 0 0
ARF1 0.027 0.006 -10000 0 -10000 0 0
ARF6/GDP 0.021 0.037 -10000 0 -0.37 1 1
ARF1/GDP 0.013 0.066 -10000 0 -0.29 3 3
ARF6 0.032 0.01 -10000 0 -10000 0 0
RAB11A 0.028 0.004 -10000 0 -10000 0 0
TIAM1 0.027 0.009 -10000 0 -10000 0 0
fibronectin binding 0 0 -10000 0 -10000 0 0
MAPK1 0.015 0.027 -10000 0 -10000 0 0
actin filament bundle formation -0.02 0.067 0.3 2 -10000 0 2
KALRN 0.008 0.031 -10000 0 -0.27 2 2
RAB11FIP3/RAB11A 0.037 0.014 -10000 0 -10000 0 0
RhoA/GDP 0.02 0.067 -10000 0 -0.3 2 2
NME1 0.025 0.013 -10000 0 -10000 0 0
Rac1/GDP 0.013 0.067 -10000 0 -0.29 3 3
substrate adhesion-dependent cell spreading 0.008 0.042 -10000 0 -10000 0 0
cortical actin cytoskeleton organization -0.014 0.096 -10000 0 -0.36 14 14
RAC1 0.022 0.011 -10000 0 -10000 0 0
liver development 0.008 0.042 -10000 0 -10000 0 0
ARF6/GTP 0.008 0.042 -10000 0 -10000 0 0
RhoA/GTP 0.025 0.037 -10000 0 -10000 0 0
mol:GDP 0.003 0.046 -10000 0 -0.28 1 1
ARF6/GTP/RAB11FIP3/RAB11A 0.04 0.039 -10000 0 -10000 0 0
RHOA 0.027 0.006 -10000 0 -10000 0 0
PLD1 0.009 0.034 -10000 0 -10000 0 0
RAB11FIP3 0.025 0.008 -10000 0 -10000 0 0
tube morphogenesis -0.014 0.095 -10000 0 -0.36 14 14
ruffle organization 0.001 0.05 -10000 0 -10000 0 0
regulation of epithelial cell migration 0.008 0.042 -10000 0 -10000 0 0
PLD2 0.009 0.033 -10000 0 -10000 0 0
PIP5K1A 0.001 0.05 -10000 0 -10000 0 0
mol:Phosphatidic acid 0.002 0.027 -10000 0 -10000 0 0
Rac1/GTP -0.014 0.096 -10000 0 -0.36 14 14
Insulin-mediated glucose transport

Figure S103.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S103.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Insulin responsive Vesicles 0.023 0.11 -10000 0 -0.39 5 5
CaM/Ca2+ 0.019 0.005 -10000 0 -10000 0 0
AKT1 0.026 0.008 -10000 0 -10000 0 0
AKT2 0.028 0.003 -10000 0 -10000 0 0
STXBP4 0.026 0.008 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
mol:glucose 0.019 0.13 0.3 9 -0.37 10 19
YWHAZ 0.027 0.004 -10000 0 -10000 0 0
CALM1 0.026 0.007 -10000 0 -10000 0 0
YWHAQ 0.027 0.005 -10000 0 -10000 0 0
TBC1D4 0.012 0.004 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
YWHAH 0.025 0.008 -10000 0 -10000 0 0
YWHAB 0.027 0.006 -10000 0 -10000 0 0
SNARE/Synip 0.048 0.021 -10000 0 -10000 0 0
YWHAG 0.023 0.011 -10000 0 -10000 0 0
ASIP -0.01 0.045 -10000 0 -10000 0 0
PRKCI 0.027 0.005 -10000 0 -10000 0 0
AS160/CaM/Ca2+ 0.019 0.005 -10000 0 -10000 0 0
RHOQ 0.027 0.004 -10000 0 -10000 0 0
GYS1 0.011 0.004 -10000 0 -10000 0 0
PRKCZ 0.025 0.008 -10000 0 -10000 0 0
TRIP10 0.028 0.003 -10000 0 -10000 0 0
TC10/GTP/CIP4/Exocyst 0.037 0.007 -10000 0 -10000 0 0
AS160/14-3-3 0.001 0.05 -10000 0 -0.34 1 1
VAMP2 0.025 0.008 -10000 0 -10000 0 0
SLC2A4 0.017 0.14 0.32 8 -0.41 10 18
STX4 0.025 0.008 -10000 0 -10000 0 0
GSK3B 0.02 0.008 -10000 0 -10000 0 0
SFN -0.019 0.048 -10000 0 -10000 0 0
LNPEP 0.027 0.005 -10000 0 -10000 0 0
YWHAE 0.026 0.008 -10000 0 -10000 0 0
Signaling events mediated by HDAC Class I

Figure S104.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S104.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NF kappa B/RelA 0.054 0.055 -10000 0 -0.36 1 1
Ran/GTP/Exportin 1/HDAC1 -0.008 0.003 -10000 0 -10000 0 0
NF kappa B1 p50/RelA/I kappa B alpha 0.028 0.064 -10000 0 -0.31 1 1
SUMO1 0.028 0.004 -10000 0 -10000 0 0
ZFPM1 0.026 0.008 -10000 0 -10000 0 0
NPC/RanGAP1/SUMO1/Ubc9 0.013 0.006 -10000 0 -10000 0 0
FKBP3 0.026 0.007 -10000 0 -10000 0 0
Histones 0.061 0.043 -10000 0 -10000 0 0
YY1/LSF 0.015 0.063 -10000 0 -0.29 1 1
SMG5 0.027 0.005 -10000 0 -10000 0 0
RAN 0.027 0.006 -10000 0 -10000 0 0
I kappa B alpha/HDAC3 0.019 0.034 -10000 0 -0.31 1 1
I kappa B alpha/HDAC1 0.027 0.048 -10000 0 -10000 0 0
SAP18 0.027 0.006 -10000 0 -10000 0 0
RELA 0.02 0.036 -10000 0 -0.22 2 2
HDAC1/Smad7 0.039 0.027 -10000 0 -10000 0 0
RANGAP1 0.025 0.008 -10000 0 -10000 0 0
HDAC3/TR2 0.031 0.036 -10000 0 -10000 0 0
NuRD/MBD3 Complex 0.027 0.047 -10000 0 -0.34 2 2
NF kappa B1 p50/RelA 0.029 0.068 0.32 1 -10000 0 1
EntrezGene:23225 0 0 -10000 0 -10000 0 0
GATA2 -0.083 0.25 -10000 0 -0.66 34 34
GATA1 0.014 0.028 -10000 0 -10000 0 0
Mad/Max 0.038 0.012 -10000 0 -10000 0 0
NuRD/MBD3 Complex/GATA1/Fog1 0.024 0.061 -10000 0 -0.3 2 2
RBBP7 0.028 0.003 -10000 0 -10000 0 0
NPC 0.016 0.002 -10000 0 -10000 0 0
RBBP4 0.026 0.007 -10000 0 -10000 0 0
MAX 0.026 0.007 -10000 0 -10000 0 0
EntrezGene:9972 0 0 -10000 0 -10000 0 0
FBXW11 0.027 0.005 -10000 0 -10000 0 0
NFKBIA 0.018 0.023 -10000 0 -10000 0 0
KAT2B 0.027 0.006 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
SIN3/HDAC complex 0.026 0.016 -10000 0 -10000 0 0
SIN3 complex 0.066 0.021 -10000 0 -10000 0 0
SMURF1 0.023 0.011 -10000 0 -10000 0 0
CHD3 0.025 0.008 -10000 0 -10000 0 0
SAP30 0.026 0.01 -10000 0 -10000 0 0
EntrezGene:23636 0 0 -10000 0 -10000 0 0
NCOR1 0.026 0.008 -10000 0 -10000 0 0
YY1/HDAC3 0.013 0.054 -10000 0 -10000 0 0
YY1/HDAC2 0.016 0.064 -10000 0 -0.29 1 1
YY1/HDAC1 0.019 0.06 -10000 0 -0.27 1 1
NuRD/MBD2 Complex (MeCP1) 0.024 0.052 -10000 0 -0.39 2 2
PPARG 0.017 0.041 -10000 0 -0.31 2 2
HDAC8/hEST1B 0.055 0.012 -10000 0 -10000 0 0
UBE2I 0.025 0.008 -10000 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.027 0.005 -10000 0 -10000 0 0
TNFRSF1A 0.027 0.007 -10000 0 -10000 0 0
HDAC3/SMRT (N-CoR2) 0.03 0.036 -10000 0 -10000 0 0
MBD3L2 -0.019 0.002 -10000 0 -10000 0 0
ubiquitin-dependent protein catabolic process 0.039 0.026 -10000 0 -10000 0 0
CREBBP 0.025 0.008 -10000 0 -10000 0 0
NuRD/MBD3/MBD3L2 Complex 0.02 0.069 -10000 0 -0.3 3 3
HDAC1 0.026 0.007 -10000 0 -10000 0 0
HDAC3 0.019 0.023 -10000 0 -10000 0 0
HDAC2 0.027 0.005 -10000 0 -10000 0 0
YY1 0.016 0.009 -10000 0 -10000 0 0
HDAC8 0.028 0.002 -10000 0 -10000 0 0
SMAD7 0.026 0.008 -10000 0 -10000 0 0
NCOR2 0.027 0.006 -10000 0 -10000 0 0
MXD1 0.028 0.004 -10000 0 -10000 0 0
STAT3 0.018 0.01 -10000 0 -10000 0 0
NFKB1 0.027 0.006 -10000 0 -10000 0 0
EntrezGene:8021 0 0 -10000 0 -10000 0 0
RANBP2 0.028 0.003 -10000 0 -10000 0 0
YY1/LSF/HDAC1 0.032 0.061 -10000 0 -10000 0 0
YY1/SAP30/HDAC1 0.035 0.061 -10000 0 -10000 0 0
EP300 0.025 0.009 -10000 0 -10000 0 0
STAT3 (dimer non-phopshorylated) 0.018 0.009 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.018 0.023 -10000 0 -10000 0 0
histone deacetylation 0.021 0.06 -10000 0 -0.3 5 5
STAT3 (dimer non-phopshorylated)/HDAC3 0.017 0.035 -10000 0 -10000 0 0
nuclear export -0.054 0.011 -10000 0 -10000 0 0
PRKACA 0.028 0.002 -10000 0 -10000 0 0
GATAD2B 0.027 0.006 -10000 0 -10000 0 0
GATAD2A 0.028 0.003 -10000 0 -10000 0 0
GATA2/HDAC3 -0.035 0.16 -10000 0 -0.39 34 34
GATA1/HDAC1 0.033 0.022 -10000 0 -10000 0 0
GATA1/HDAC3 0.03 0.04 -10000 0 -10000 0 0
CHD4 0.027 0.007 -10000 0 -10000 0 0
TNF-alpha/TNFR1A 0.028 0.056 -10000 0 -0.5 2 2
SIN3/HDAC complex/Mad/Max 0.026 0.028 -10000 0 -10000 0 0
NuRD Complex 0.017 0.078 -10000 0 -0.33 4 4
positive regulation of chromatin silencing 0.058 0.041 -10000 0 -10000 0 0
SIN3B 0.028 0.002 -10000 0 -10000 0 0
MTA2 0.028 0.002 -10000 0 -10000 0 0
SIN3A 0.028 0.004 -10000 0 -10000 0 0
XPO1 0.028 0.004 -10000 0 -10000 0 0
SUMO1/HDAC1 0.04 0.037 -10000 0 -10000 0 0
HDAC complex 0.065 0.022 -10000 0 -10000 0 0
GATA1/Fog1 0.032 0.023 -10000 0 -10000 0 0
FKBP25/HDAC1/HDAC2 0.05 0.019 -10000 0 -10000 0 0
TNF 0.014 0.07 -10000 0 -0.66 2 2
negative regulation of cell growth 0.024 0.037 -10000 0 -10000 0 0
NuRD/MBD2/PRMT5 Complex 0.024 0.052 -10000 0 -0.39 2 2
Ran/GTP/Exportin 1 0.035 0.04 -10000 0 -10000 0 0
NF kappa B/RelA/I kappa B alpha 0.015 0.049 -10000 0 -0.3 2 2
SIN3/HDAC complex/NCoR1 0.014 0.069 -10000 0 -0.4 2 2
TFCP2 0.027 0.006 -10000 0 -10000 0 0
NR2C1 0.027 0.005 -10000 0 -10000 0 0
MBD3 0.028 0.003 -10000 0 -10000 0 0
MBD2 0.026 0.008 -10000 0 -10000 0 0
Retinoic acid receptors-mediated signaling

Figure S105.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S105.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.026 0.007 -10000 0 -10000 0 0
HDAC3 0.027 0.005 -10000 0 -10000 0 0
VDR 0.017 0.081 -10000 0 -0.66 3 3
Cbp/p300/PCAF 0.046 0.023 -10000 0 -10000 0 0
EP300 0.025 0.009 -10000 0 -10000 0 0
RARs/AIB1/Cbp/p300/PCAF/9cRA 0.013 0.061 -10000 0 -0.31 3 3
KAT2B 0.027 0.006 -10000 0 -10000 0 0
MAPK14 0.027 0.006 -10000 0 -10000 0 0
AKT1 0.014 0.046 0.21 1 -10000 0 1
RAR alpha/9cRA/Cyclin H 0.047 0.055 -10000 0 -10000 0 0
mol:9cRA 0 0 -10000 0 -10000 0 0
RARs/Src-1/Cbp/p300/PCAF/9cRA 0.031 0.051 0.24 3 -0.38 1 4
CDC2 0 0 -10000 0 -10000 0 0
response to UV 0.001 0 -10000 0 -10000 0 0
RAR alpha/Jnk1 0.028 0.072 -10000 0 -0.42 4 4
NCOR2 0.027 0.006 -10000 0 -10000 0 0
VDR/VDR/Vit D3 0.013 0.061 -10000 0 -0.49 3 3
RXRs/RARs/NRIP1/9cRA 0.025 0.067 0.43 1 -0.52 1 2
NCOA2 -0.031 0.19 -10000 0 -0.66 18 18
NCOA3 0.027 0.006 -10000 0 -10000 0 0
NCOA1 0.027 0.005 -10000 0 -10000 0 0
VDR/VDR/DNA 0.017 0.081 -10000 0 -0.66 3 3
RARG 0.027 0.009 -10000 0 -10000 0 0
RAR gamma1/9cRA 0.037 0.009 -10000 0 -10000 0 0
MAPK3 0.026 0.008 -10000 0 -10000 0 0
MAPK1 0.025 0.008 -10000 0 -10000 0 0
MAPK8 0.017 0.085 -10000 0 -0.58 4 4
mol:Vit D3 0 0 -10000 0 -10000 0 0
RXRs/VDR/DNA/Vit D3 0.026 0.064 -10000 0 -0.36 1 1
RARA 0.013 0.028 -10000 0 -0.25 2 2
negative regulation of phosphoinositide 3-kinase cascade 0 0 -10000 0 -10000 0 0
RARs/TIF2/Cbp/p300/PCAF/9cRA 0.008 0.1 0.23 2 -0.45 4 6
PRKCA 0.028 0.009 -10000 0 -10000 0 0
RXRs/RARs/NRIP1/9cRA/HDAC1 0.034 0.082 0.33 2 -0.59 1 3
RXRG 0.01 0.015 -10000 0 -10000 0 0
RXRA 0.017 0.046 -10000 0 -0.28 2 2
RXRB 0.013 0.015 -10000 0 -10000 0 0
VDR/Vit D3/DNA 0.013 0.061 -10000 0 -0.49 3 3
RBP1 0.027 0.006 -10000 0 -10000 0 0
CRBP1/9-cic-RA 0.02 0.004 -10000 0 -10000 0 0
RARB 0.028 0.006 -10000 0 -10000 0 0
PRKCG 0.003 0.042 -10000 0 -10000 0 0
MNAT1 0.026 0.007 -10000 0 -10000 0 0
RAR alpha/RXRs 0.018 0.059 -10000 0 -0.47 1 1
RXRs/RARs/SMRT(N-CoR2)/9cRA 0.025 0.056 -10000 0 -0.46 1 1
proteasomal ubiquitin-dependent protein catabolic process 0.035 0.093 0.31 11 -0.36 2 13
RXRs/RARs/NRIP1/9cRA/HDAC3 0.036 0.081 0.36 3 -0.55 1 4
positive regulation of DNA binding 0.033 0.046 -10000 0 -10000 0 0
NRIP1 0.031 0.076 -10000 0 -0.56 1 1
RXRs/RARs 0.024 0.069 0.29 1 -0.61 1 2
RXRs/RXRs/DNA/9cRA 0.017 0.048 -10000 0 -0.36 1 1
PRKACA 0.028 0.002 -10000 0 -10000 0 0
CDK7 0.027 0.004 -10000 0 -10000 0 0
TFIIH 0.052 0.016 -10000 0 -10000 0 0
RAR alpha/9cRA 0.059 0.045 -10000 0 -10000 0 0
CCNH 0.027 0.005 -10000 0 -10000 0 0
CREBBP 0.025 0.008 -10000 0 -10000 0 0
RAR gamma2/9cRA 0.048 0.021 -10000 0 -10000 0 0
IL2 signaling events mediated by PI3K

Figure S106.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S106.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.022 0.044 -10000 0 -10000 0 0
UGCG -0.009 0.15 -10000 0 -0.63 11 11
AKT1/mTOR/p70S6K/Hsp90/TERT 0.032 0.12 0.28 4 -0.43 8 12
mol:GTP 0 0 -10000 0 -10000 0 0
mol:glucosylceramide -0.008 0.15 -10000 0 -0.62 11 11
mol:DAG -0.002 0.11 -10000 0 -0.79 4 4
CaM/Ca2+/Calcineurin A alpha-beta B1 0.047 0.093 0.29 3 -0.38 3 6
FRAP1 0.04 0.1 0.31 3 -0.45 3 6
FOXO3 0.034 0.1 0.3 3 -0.44 3 6
AKT1 0.037 0.11 0.32 3 -0.48 3 6
GAB2 0.029 0.003 -10000 0 -10000 0 0
SMPD1 0.011 0.095 -10000 0 -0.59 5 5
SGMS1 0.013 0.093 -10000 0 -0.64 4 4
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
mol:GDP 0.008 0.002 -10000 0 -10000 0 0
CALM1 0.026 0.007 -10000 0 -10000 0 0
cell proliferation 0.016 0.12 0.25 2 -0.46 10 12
EIF3A 0.028 0.003 -10000 0 -10000 0 0
PI3K 0.044 0.01 -10000 0 -10000 0 0
RPS6KB1 0.022 0.015 -10000 0 -10000 0 0
mol:sphingomyelin -0.002 0.11 -10000 0 -0.79 4 4
natural killer cell activation 0.001 0 -10000 0 -10000 0 0
JAK3 0.009 0.041 -10000 0 -10000 0 0
PIK3R1 0.03 0.005 -10000 0 -10000 0 0
JAK1 0.028 0.007 -10000 0 -10000 0 0
NFKB1 0.027 0.006 -10000 0 -10000 0 0
MYC 0.038 0.1 0.4 2 -0.46 1 3
MYB 0.009 0.028 -10000 0 -10000 0 0
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K 0.027 0.082 -10000 0 -0.38 3 3
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 0.052 0.022 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 0.027 0.08 -10000 0 -0.37 3 3
Rac1/GDP 0.021 0.011 -10000 0 -10000 0 0
T cell proliferation 0.042 0.052 0.28 2 -0.35 1 3
SHC1 0.028 0.005 -10000 0 -10000 0 0
RAC1 0.022 0.011 -10000 0 -10000 0 0
positive regulation of cyclin-dependent protein kinase activity 0.001 0.004 -10000 0 -10000 0 0
PRKCZ 0.041 0.039 -10000 0 -10000 0 0
NF kappa B1 p50/RelA 0.062 0.097 0.3 3 -0.38 3 6
IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K 0.027 0.022 -10000 0 -10000 0 0
HSP90AA1 0.026 0.008 -10000 0 -10000 0 0
RELA 0.028 0.002 -10000 0 -10000 0 0
IL2RA 0.017 0.031 -10000 0 -10000 0 0
IL2RB 0.017 0.031 -10000 0 -10000 0 0
TERT -0.016 0.028 -10000 0 -10000 0 0
E2F1 0.016 0.022 -10000 0 -10000 0 0
SOS1 0.028 0.004 -10000 0 -10000 0 0
RPS6 0.026 0.007 -10000 0 -10000 0 0
mol:cAMP -0.001 0.002 -10000 0 -10000 0 0
PTPN11 0.028 0.006 -10000 0 -10000 0 0
IL2RG 0.027 0.018 -10000 0 -10000 0 0
actin cytoskeleton organization 0.042 0.052 0.28 2 -0.35 1 3
GRB2 0.026 0.008 -10000 0 -10000 0 0
IL2 0.022 0.01 -10000 0 -10000 0 0
PIK3CA 0.029 0.005 -10000 0 -10000 0 0
Rac1/GTP 0.045 0.024 -10000 0 -10000 0 0
LCK 0.026 0.017 -10000 0 -10000 0 0
BCL2 0.04 0.087 -10000 0 -10000 0 0
TCGA08_retinoblastoma

Figure S107.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S107.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDKN2B 0.025 0.019 -10000 0 -9999 0 0
CDKN2C 0.031 0.015 -10000 0 -9999 0 0
CDKN2A -0.048 0.041 -10000 0 -9999 0 0
CCND2 0.004 0.007 -10000 0 -9999 0 0
RB1 -0.009 0.016 -10000 0 -9999 0 0
CDK4 0.006 0.008 -10000 0 -9999 0 0
CDK6 0.006 0.008 -10000 0 -9999 0 0
G1/S progression 0.018 0.038 0.18 9 -9999 0 9
Insulin Pathway

Figure S108.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S108.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CBL/APS/CAP 0.036 0.056 -10000 0 -0.36 3 3
TC10/GTP 0.035 0.026 -10000 0 -10000 0 0
Insulin Receptor/Insulin/IRS1/Shp2 0.055 0.063 -10000 0 -0.41 3 3
HRAS 0.028 0.003 -10000 0 -10000 0 0
APS homodimer 0.023 0.011 -10000 0 -10000 0 0
GRB14 -0.011 0.16 -10000 0 -0.61 13 13
FOXO3 0.006 0.12 -10000 0 -0.72 5 5
AKT1 -0.013 0.12 0.4 7 -10000 0 7
INSR 0.031 0.008 -10000 0 -10000 0 0
Insulin Receptor/Insulin 0.053 0.015 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
GRB10 0.023 0.011 -10000 0 -10000 0 0
SORBS1 0.028 0.003 -10000 0 -10000 0 0
CRK 0.026 0.008 -10000 0 -10000 0 0
PTPN1 0.004 0.001 -10000 0 -10000 0 0
CAV1 -0.014 0.048 -10000 0 -0.38 3 3
CBL/APS/CAP/Crk-II/C3G 0.055 0.04 -10000 0 -10000 0 0
Insulin Receptor/Insulin/IRS1/NCK2 0.058 0.062 -10000 0 -0.41 3 3
mol:GDP 0 0 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 0.044 0.055 -10000 0 -0.36 3 3
Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B 0.026 0.046 -10000 0 -10000 0 0
RPS6KB1 -0.023 0.091 0.34 3 -10000 0 3
PARD6A 0.026 0.007 -10000 0 -10000 0 0
CBL 0.027 0.005 -10000 0 -10000 0 0
tumor necrosis factor-mediated signaling pathway 0 0 -10000 0 -10000 0 0
DOK1 0.012 0.057 -10000 0 -0.56 2 2
PIK3R1 0.027 0.004 -10000 0 -10000 0 0
Insulin Receptor/Insuli/IRS1/GRB2/Shc 0.015 0.088 -10000 0 -0.33 3 3
HRAS/GTP 0.012 0.044 -10000 0 -0.34 3 3
Insulin Receptor 0.031 0.008 -10000 0 -10000 0 0
Insulin Receptor/Insuli/IRS1/GRB2/SHC 0.062 0.062 -10000 0 -0.39 3 3
PRKCI 0.023 0.046 -10000 0 -10000 0 0
Insulin Receptor/Insulin/GRB14/PDK1 0.004 0.097 -10000 0 -0.35 14 14
SHC1 0.027 0.005 -10000 0 -10000 0 0
negative regulation of MAPKKK cascade 0.035 0.058 -10000 0 -0.47 2 2
PI3K 0.055 0.058 -10000 0 -0.37 3 3
NCK2 0.028 0.003 -10000 0 -10000 0 0
RHOQ 0.027 0.004 -10000 0 -10000 0 0
mol:H2O2 0 0.001 -10000 0 -10000 0 0
HRAS/GDP 0.021 0.002 -10000 0 -10000 0 0
AKT2 -0.014 0.12 0.4 7 -0.34 12 19
PRKCZ -0.004 0.1 -10000 0 -0.5 1 1
SH2B2 0.023 0.011 -10000 0 -10000 0 0
SHC/SHIP 0.02 0.05 -10000 0 -0.36 3 3
F2RL2 0.006 0.096 -10000 0 -0.66 4 4
TRIP10 0.028 0.003 -10000 0 -10000 0 0
Insulin Receptor/Insulin/Shc 0.049 0.016 -10000 0 -10000 0 0
TC10/GTP/CIP4/Exocyst 0.037 0.007 -10000 0 -10000 0 0
Insulin Receptor/Insulin/SHC/GRB2/Sos1 0.07 0.03 -10000 0 -10000 0 0
RAPGEF1 0.026 0.007 -10000 0 -10000 0 0
RASA1 0.027 0.005 -10000 0 -10000 0 0
NCK1 0.027 0.006 -10000 0 -10000 0 0
CBL/APS/CAP/Crk-II 0.051 0.033 -10000 0 -10000 0 0
TC10/GDP 0.02 0.003 -10000 0 -10000 0 0
Insulin Receptor/Insulin/SHC/GRB10 0.052 0.031 -10000 0 -10000 0 0
INPP5D -0.015 0.047 -10000 0 -0.38 3 3
SOS1 0.027 0.004 -10000 0 -10000 0 0
SGK1 -0.003 0.11 -10000 0 -0.68 5 5
mol:cAMP 0 0 -10000 0 -10000 0 0
PTPN11 0.027 0.006 -10000 0 -10000 0 0
IRS1 0.015 0.085 -10000 0 -0.58 4 4
p62DOK/RasGAP 0.035 0.059 -10000 0 -0.48 2 2
INS 0.022 0.009 -10000 0 -10000 0 0
mol:PI-3-4-P2 -0.015 0.047 -10000 0 -0.38 3 3
GRB2 0.026 0.008 -10000 0 -10000 0 0
EIF4EBP1 -0.017 0.11 0.39 6 -10000 0 6
PTPRA 0.028 0.007 -10000 0 -10000 0 0
PIK3CA 0.027 0.005 -10000 0 -10000 0 0
TC10/GTP/CIP4 0.037 0.007 -10000 0 -10000 0 0
PDPK1 0.025 0.008 -10000 0 -10000 0 0
Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos 0.021 0.039 -10000 0 -0.28 3 3
Insulin Receptor/Insulin/IRS1 0.041 0.059 -10000 0 -0.35 4 4
Insulin Receptor/Insulin/IRS3 0.039 0.015 -10000 0 -10000 0 0
Par3/Par6 0.05 0.063 -10000 0 -0.38 4 4
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Figure S109.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S109.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HIF3A -0.027 0.18 -9999 0 -0.64 17 17
oxygen homeostasis 0 0 -9999 0 -10000 0 0
TCEB2 0.025 0.011 -9999 0 -10000 0 0
TCEB1 0.027 0.005 -9999 0 -10000 0 0
HIF1A/p53 0.019 0.038 -9999 0 -0.28 2 2
HIF1A 0.01 0.023 -9999 0 -0.26 1 1
COPS5 0.027 0.005 -9999 0 -10000 0 0
VHL/Elongin B/Elongin C/RBX1/CUL2 0.066 0.035 -9999 0 -10000 0 0
FIH (dimer) 0.028 0.003 -9999 0 -10000 0 0
CDKN2A -0.049 0.04 -9999 0 -10000 0 0
ARNT/IPAS -0.003 0.14 -9999 0 -0.48 17 17
HIF1AN 0.028 0.003 -9999 0 -10000 0 0
GNB2L1 0.027 0.005 -9999 0 -10000 0 0
HIF1A/ARNT 0.022 0.038 -9999 0 -0.28 2 2
CUL2 0.027 0.005 -9999 0 -10000 0 0
OS9 0.027 0.005 -9999 0 -10000 0 0
RACK1/Elongin B/Elongin C 0.049 0.02 -9999 0 -10000 0 0
response to hypoxia 0 0 -9999 0 -10000 0 0
HIF1A/Hsp90 0.026 0.034 -9999 0 -0.27 2 2
PHD1-3/OS9 0.063 0.025 -9999 0 -10000 0 0
HIF1A/RACK1/Elongin B/Elongin C 0.039 0.045 -9999 0 -0.3 1 1
VHL 0.027 0.006 -9999 0 -10000 0 0
HSP90AA1 0.026 0.008 -9999 0 -10000 0 0
HIF1A/JAB1 0.022 0.039 -9999 0 -0.28 2 2
EGLN3 0.024 0.017 -9999 0 -10000 0 0
EGLN2 0.028 0.003 -9999 0 -10000 0 0
EGLN1 0.027 0.006 -9999 0 -10000 0 0
TP53 0.025 0.008 -9999 0 -10000 0 0
VHL/Elongin B/Elongin C/RBX1/CUL2/HIF1A 0.015 0.11 -9999 0 -0.54 8 8
ARNT 0.027 0.005 -9999 0 -10000 0 0
ARD1A 0 0 -9999 0 -10000 0 0
RBX1 0.025 0.008 -9999 0 -10000 0 0
HIF1A/p19ARF -0.011 0.039 -9999 0 -0.28 2 2
Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Figure S110.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S110.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SMAD4 0.026 0.008 -9999 0 -10000 0 0
SMAD2 -0.013 0.054 -9999 0 -0.25 2 2
SMAD3 0.021 0.021 -9999 0 -10000 0 0
SMAD3/SMAD4 0.015 0.091 -9999 0 -0.43 6 6
SMAD4/Ubc9/PIASy 0.048 0.022 -9999 0 -10000 0 0
SMAD2/SMAD2/SMAD4 0.027 0.066 -9999 0 -10000 0 0
PPM1A 0.026 0.007 -9999 0 -10000 0 0
CALM1 0.026 0.007 -9999 0 -10000 0 0
SMAD2/SMAD4 -0.002 0.059 -9999 0 -0.25 1 1
MAP3K1 0.027 0.004 -9999 0 -10000 0 0
TRAP-1/SMAD4 0.03 0.064 -9999 0 -0.49 3 3
MAPK3 0.026 0.008 -9999 0 -10000 0 0
MAPK1 0.025 0.008 -9999 0 -10000 0 0
NUP214 0.026 0.007 -9999 0 -10000 0 0
CTDSP1 0.027 0.005 -9999 0 -10000 0 0
CTDSP2 0.027 0.005 -9999 0 -10000 0 0
CTDSPL 0.027 0.006 -9999 0 -10000 0 0
KPNB1 0.026 0.008 -9999 0 -10000 0 0
TGFBRAP1 0.018 0.081 -9999 0 -0.66 3 3
UBE2I 0.025 0.008 -9999 0 -10000 0 0
NUP153 0.027 0.006 -9999 0 -10000 0 0
KPNA2 0.026 0.008 -9999 0 -10000 0 0
PIAS4 0.028 0.003 -9999 0 -10000 0 0
Canonical NF-kappaB pathway

Figure S111.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S111.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
FBXW11 0.029 0.006 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
NF kappa B1 p50/RelA/I kappa B alpha 0.051 0.086 0.32 6 -0.34 1 7
ERC1 0.027 0.006 -10000 0 -10000 0 0
RIP2/NOD2 0.032 0.024 -10000 0 -10000 0 0
NFKBIA 0.012 0.005 -10000 0 -10000 0 0
BIRC2 0.027 0.005 -10000 0 -10000 0 0
IKBKB 0.027 0.005 -10000 0 -10000 0 0
RIPK2 0.027 0.004 -10000 0 -10000 0 0
IKBKG 0.025 0.02 -10000 0 -10000 0 0
IKK complex/A20 0.055 0.068 -10000 0 -0.45 1 1
NEMO/A20/RIP2 0.027 0.004 -10000 0 -10000 0 0
XPO1 0.028 0.004 -10000 0 -10000 0 0
NEMO/ATM 0.045 0.056 -10000 0 -0.43 1 1
tumor necrosis factor receptor activity 0 0 -10000 0 -10000 0 0
RAN 0.027 0.006 -10000 0 -10000 0 0
Exportin 1/RanGTP 0.036 0.009 -10000 0 -10000 0 0
IKK complex/ELKS 0.05 0.055 -10000 0 -0.42 1 1
BCL10/MALT1/TRAF6 0.05 0.019 -10000 0 -10000 0 0
NOD2 0.02 0.025 -10000 0 -10000 0 0
NFKB1 0.029 0.007 -10000 0 -10000 0 0
RELA 0.03 0.002 -10000 0 -10000 0 0
MALT1 0.026 0.008 -10000 0 -10000 0 0
cIAP1/UbcH5C 0.039 0.011 -10000 0 -10000 0 0
ATM 0.027 0.005 -10000 0 -10000 0 0
TNF/TNFR1A 0.028 0.056 -10000 0 -0.5 2 2
TRAF6 0.028 0.004 -10000 0 -10000 0 0
PRKCA 0.026 0.008 -10000 0 -10000 0 0
CHUK 0.028 0.003 -10000 0 -10000 0 0
UBE2D3 0.027 0.006 -10000 0 -10000 0 0
TNF 0.014 0.07 -10000 0 -0.66 2 2
NF kappa B1 p50/RelA 0.059 0.018 -10000 0 -10000 0 0
BCL10 0.027 0.007 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.012 0.005 -10000 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.029 0.006 -10000 0 -10000 0 0
TNFRSF1A 0.027 0.007 -10000 0 -10000 0 0
IKK complex 0.056 0.059 -10000 0 -0.44 1 1
CYLD 0.026 0.007 -10000 0 -10000 0 0
IKK complex/PKC alpha 0.059 0.06 -10000 0 -0.43 1 1
PLK2 and PLK4 events

Figure S112.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S112.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PLK2 0.021 0.025 -9999 0 -9999 0 0
PLK4 0.026 0.012 -9999 0 -9999 0 0
regulation of centriole replication 0.009 0.016 -9999 0 -9999 0 0
Visual signal transduction: Cones

Figure S113.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S113.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Cone Metarhodopsin II/Cone Transducin 0.037 0.036 -9999 0 -0.37 1 1
RGS9BP 0.023 0.048 -9999 0 -0.66 1 1
mol:GTP 0 0 -9999 0 -10000 0 0
GRK1 -0.008 0.02 -9999 0 -10000 0 0
mol:Na + 0.025 0.014 -9999 0 -10000 0 0
mol:ADP -0.015 0.012 -9999 0 -10000 0 0
GNAT2 0.018 0.019 -9999 0 -10000 0 0
RGS9-1/Gbeta5/R9AP 0.039 0.07 -9999 0 -0.44 4 4
mol:GDP 0 0 -9999 0 -10000 0 0
PDE6H/GNAT2/GTP 0.028 0.01 -9999 0 -10000 0 0
GRK7 0.004 0.025 -9999 0 -10000 0 0
CNGB3 -0.007 0.024 -9999 0 -10000 0 0
Cone Metarhodopsin II/X-Arrestin 0.015 0.003 -9999 0 -10000 0 0
mol:Ca2+ -0.015 0.027 -9999 0 -10000 0 0
Cone PDE6 0.054 0.067 -9999 0 -0.39 4 4
Cone Metarhodopsin II 0.024 0.012 -9999 0 -10000 0 0
Na + (4 Units) 0.033 0.019 -9999 0 -10000 0 0
GNAT2/GDP 0.047 0.064 -9999 0 -0.38 4 4
GNB5 0.027 0.005 -9999 0 -10000 0 0
mol:GMP (4 units) -0.005 0.042 -9999 0 -10000 0 0
Cone Transducin 0.04 0.039 -9999 0 -0.4 1 1
SLC24A2 -0.013 0.015 -9999 0 -10000 0 0
GNB3/GNGT2 0.031 0.042 -9999 0 -0.5 1 1
GNB3 0.023 0.019 -9999 0 -10000 0 0
GNAT2/GTP 0.018 0.005 -9999 0 -10000 0 0
CNGA3 -0.002 0.024 -9999 0 -10000 0 0
ARR3 -0.01 0.018 -9999 0 -10000 0 0
absorption of light 0 0 -9999 0 -10000 0 0
cGMP/Cone CNG Channel 0.025 0.015 -9999 0 -10000 0 0
mol:Pi 0.038 0.07 -9999 0 -0.44 4 4
Cone CNG Channel 0.044 0.025 -9999 0 -10000 0 0
mol:all-trans-retinal 0 0 -9999 0 -10000 0 0
mol:K + -0.013 0.015 -9999 0 -10000 0 0
RGS9 0.014 0.082 -9999 0 -0.66 3 3
PDE6C -0.004 0.022 -9999 0 -10000 0 0
GNGT2 0.022 0.048 -9999 0 -0.66 1 1
mol:cGMP (4 units) 0 0 -9999 0 -10000 0 0
PDE6H -0.01 0.018 -9999 0 -10000 0 0
Circadian rhythm pathway

Figure S114.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S114.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
chromatin modification 0.052 0.021 -9999 0 -10000 0 0
CLOCK 0.021 0.071 -9999 0 -0.55 3 3
TIMELESS/CRY2 0.041 0.021 -9999 0 -10000 0 0
DEC1/BMAL1 0.035 0.01 -9999 0 -10000 0 0
ATR 0.027 0.006 -9999 0 -10000 0 0
NR1D1 0.02 0.015 -9999 0 -10000 0 0
ARNTL 0.03 0.005 -9999 0 -10000 0 0
TIMELESS 0.021 0.013 -9999 0 -10000 0 0
NPAS2 0.03 0.004 -9999 0 -10000 0 0
CRY2 0.028 0.004 -9999 0 -10000 0 0
mol:CO -0.009 0.002 -9999 0 -10000 0 0
CHEK1 0.027 0.005 -9999 0 -10000 0 0
mol:HEME 0.009 0.002 -9999 0 -10000 0 0
PER1 0.025 0.008 -9999 0 -10000 0 0
BMAL/CLOCK/NPAS2 0.057 0.053 -9999 0 -0.42 2 2
BMAL1/CLOCK 0.028 0.074 -9999 0 -10000 0 0
S phase of mitotic cell cycle 0.052 0.021 -9999 0 -10000 0 0
TIMELESS/CHEK1/ATR 0.052 0.022 -9999 0 -10000 0 0
mol:NADPH 0.009 0.002 -9999 0 -10000 0 0
PER1/TIMELESS 0.036 0.019 -9999 0 -10000 0 0
PER1-2 / CRY1-2 0 0 -9999 0 -10000 0 0
DEC1 -0.009 0.019 -9999 0 -10000 0 0
JNK signaling in the CD4+ TCR pathway

Figure S115.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S115.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
LAT/GRAP2/SLP76/HPK1 0.049 0.04 -10000 0 -10000 0 0
MAP4K1 0.016 0.033 -10000 0 -10000 0 0
MAP3K8 0.027 0.005 -10000 0 -10000 0 0
PRKCB 0.024 0.014 -10000 0 -10000 0 0
DBNL 0.023 0.011 -10000 0 -10000 0 0
CRKL 0.026 0.008 -10000 0 -10000 0 0
MAP3K1 0.028 0.037 -10000 0 -10000 0 0
JUN 0.018 0.11 -10000 0 -0.58 5 5
MAP3K7 0.029 0.036 -10000 0 -10000 0 0
GRAP2 0.023 0.017 -10000 0 -10000 0 0
CRK 0.026 0.008 -10000 0 -10000 0 0
MAP2K4 0.027 0.061 0.23 1 -0.36 1 2
LAT 0.017 0.028 -10000 0 -10000 0 0
LCP2 0.025 0.015 -10000 0 -10000 0 0
MAPK8 0.018 0.11 -10000 0 -0.58 6 6
LAT/GRAP2/SLP76/HPK1/HIP-55/CRK family 0.035 0.039 -10000 0 -10000 0 0
LAT/GRAP2/SLP76/HPK1/HIP-55 0.045 0.048 -10000 0 -10000 0 0
a4b1 and a4b7 Integrin signaling

Figure S116.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S116.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ITGB1 0.027 0.005 -9999 0 -9999 0 0
ITGB7 0.027 0.005 -9999 0 -9999 0 0
ITGA4 0.028 0.004 -9999 0 -9999 0 0
alpha4/beta7 Integrin 0.04 0.009 -9999 0 -9999 0 0
alpha4/beta1 Integrin 0.04 0.009 -9999 0 -9999 0 0
Aurora A signaling

Figure S117.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S117.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Aurora A/GADD45A 0.031 0.018 -9999 0 -10000 0 0
BIRC5 -0.012 0.047 -9999 0 -10000 0 0
NFKBIA 0.008 0.01 -9999 0 -10000 0 0
CPEB1 0.01 0.084 -9999 0 -0.66 3 3
AKT1 0.008 0.01 -9999 0 -10000 0 0
NDEL1 0.025 0.008 -9999 0 -10000 0 0
Aurora A/BRCA1 0.026 0.017 -9999 0 -10000 0 0
NDEL1/TACC3 0.042 0.024 -9999 0 -10000 0 0
GADD45A 0.026 0.007 -9999 0 -10000 0 0
GSK3B 0.027 0.007 -9999 0 -10000 0 0
PAK1/Aurora A 0.033 0.016 -9999 0 -10000 0 0
MDM2 0.027 0.006 -9999 0 -10000 0 0
JUB 0 0 -9999 0 -10000 0 0
TPX2 -0.001 0.026 -9999 0 -10000 0 0
TP53 0.02 0.024 -9999 0 -10000 0 0
DLG7 0.01 0.01 -9999 0 -10000 0 0
AURKAIP1 0.025 0.008 -9999 0 -10000 0 0
ARHGEF7 0.027 0.006 -9999 0 -10000 0 0
G2 phase of mitotic cell cycle 0 0 -9999 0 -10000 0 0
Aurora A/NDEL1/TACC3 0.045 0.026 -9999 0 -10000 0 0
G2/M transition of mitotic cell cycle 0.026 0.017 -9999 0 -10000 0 0
AURKA 0.018 0.013 -9999 0 -10000 0 0
AURKB 0.001 0.033 -9999 0 -0.16 8 8
CDC25B 0.018 0.01 -9999 0 -10000 0 0
G2/M transition checkpoint 0.01 0.012 -9999 0 -10000 0 0
mRNA polyadenylation 0.018 0.052 -9999 0 -0.38 3 3
Aurora A/CPEB 0.018 0.052 -9999 0 -0.38 3 3
Aurora A/TACC1/TRAP/chTOG 0.061 0.028 -9999 0 -10000 0 0
BRCA1 0.024 0.014 -9999 0 -10000 0 0
centrosome duplication 0.033 0.016 -9999 0 -10000 0 0
regulation of centrosome cycle 0.041 0.024 -9999 0 -10000 0 0
spindle assembly 0.059 0.027 -9999 0 -10000 0 0
TDRD7 0.027 0.007 -9999 0 -10000 0 0
Aurora A/RasGAP/Survivin 0.047 0.03 -9999 0 -10000 0 0
CENPA 0.009 0.027 -9999 0 -0.25 2 2
Aurora A/PP2A 0.031 0.019 -9999 0 -10000 0 0
meiosis 0 0 -9999 0 -10000 0 0
protein catabolic process 0.012 0.022 -9999 0 -10000 0 0
negative regulation of DNA binding 0.016 0.036 -9999 0 -10000 0 0
prophase 0 0 -9999 0 -10000 0 0
GIT1/beta-PIX 0.037 0.013 -9999 0 -10000 0 0
RASA1 0.027 0.005 -9999 0 -10000 0 0
Ajuba/Aurora A 0.01 0.012 -9999 0 -10000 0 0
mitotic prometaphase 0.002 0.014 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.018 0.013 -9999 0 -10000 0 0
TACC1 0.027 0.006 -9999 0 -10000 0 0
TACC3 0.025 0.016 -9999 0 -10000 0 0
Aurora A/Antizyme1 0.047 0.025 -9999 0 -10000 0 0
Aurora A/RasGAP 0.032 0.018 -9999 0 -10000 0 0
OAZ1 0.028 0.003 -9999 0 -10000 0 0
RAN 0.027 0.006 -9999 0 -10000 0 0
mitosis 0 0 -9999 0 -10000 0 0
PRKACA 0.028 0.006 -9999 0 -10000 0 0
GIT1 0.026 0.007 -9999 0 -10000 0 0
GIT1/beta-PIX/PAK1 0.051 0.018 -9999 0 -10000 0 0
Importin alpha/Importin beta/TPX2 -0.001 0.026 -9999 0 -10000 0 0
PPP2R5D 0.027 0.007 -9999 0 -10000 0 0
Aurora A/TPX2 0.01 0.026 -9999 0 -10000 0 0
PAK1 0.028 0.003 -9999 0 -10000 0 0
CKAP5 0.028 0.004 -9999 0 -10000 0 0
Aurora C signaling

Figure S118.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S118.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
INCENP 0.028 0.002 -9999 0 -9999 0 0
Aurora C/Aurora B/INCENP 0.011 0.043 -9999 0 -9999 0 0
metaphase 0 0 -9999 0 -9999 0 0
mitosis 0 0 -9999 0 -9999 0 0
H3F3B 0.01 0.005 -9999 0 -9999 0 0
AURKB -0.016 0.048 -9999 0 -9999 0 0
AURKC 0.028 0.003 -9999 0 -9999 0 0
Paxillin-independent events mediated by a4b1 and a4b7

Figure S119.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S119.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 0.023 0.007 -9999 0 -10000 0 0
CRKL 0.026 0.008 -9999 0 -10000 0 0
Rac1/GDP 0.017 0.008 -9999 0 -10000 0 0
DOCK1 0.028 0.003 -9999 0 -10000 0 0
ITGA4 0.028 0.004 -9999 0 -10000 0 0
alpha4/beta7 Integrin/MAdCAM1 0.063 0.021 -9999 0 -10000 0 0
EPO 0.01 0.021 -9999 0 -10000 0 0
alpha4/beta7 Integrin 0.04 0.009 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
CRK 0.026 0.008 -9999 0 -10000 0 0
alpha4/beta1 Integrin 0.04 0.009 -9999 0 -10000 0 0
EPO/EPOR (dimer) 0.031 0.017 -9999 0 -10000 0 0
lamellipodium assembly -0.003 0.085 -9999 0 -0.48 2 2
PIK3CA 0.027 0.005 -9999 0 -10000 0 0
PI3K 0.04 0.009 -9999 0 -10000 0 0
ARF6 0.026 0.007 -9999 0 -10000 0 0
JAK2 0.02 0.013 -9999 0 -10000 0 0
PXN 0.027 0.006 -9999 0 -10000 0 0
PIK3R1 0.027 0.004 -9999 0 -10000 0 0
MADCAM1 0.007 0.037 -9999 0 -10000 0 0
cell adhesion 0.06 0.021 -9999 0 -10000 0 0
CRKL/CBL 0.037 0.013 -9999 0 -10000 0 0
ITGB1 0.027 0.005 -9999 0 -10000 0 0
SRC 0.011 0.026 -9999 0 -10000 0 0
ITGB7 0.027 0.005 -9999 0 -10000 0 0
RAC1 0.022 0.011 -9999 0 -10000 0 0
alpha4/beta1 Integrin/VCAM1 0.043 0.032 -9999 0 -10000 0 0
p130Cas/Crk/Dock1 0.027 0.032 -9999 0 -10000 0 0
VCAM1 0.017 0.029 -9999 0 -10000 0 0
RHOA 0.027 0.006 -9999 0 -10000 0 0
alpha4/beta1 Integrin/Paxillin/GIT1 0.063 0.025 -9999 0 -10000 0 0
BCAR1 -0.009 0.031 -9999 0 -10000 0 0
EPOR 0.028 0.003 -9999 0 -10000 0 0
mol:GDP 0 0 -9999 0 -10000 0 0
CBL 0.027 0.005 -9999 0 -10000 0 0
GIT1 0.026 0.007 -9999 0 -10000 0 0
Rac1/GTP -0.004 0.087 -9999 0 -0.5 2 2
Signaling events mediated by HDAC Class III

Figure S120.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S120.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EP300 0.025 0.009 -9999 0 -10000 0 0
HDAC4 0.025 0.026 -9999 0 -0.34 1 1
induction of apoptosis 0 0 -9999 0 -10000 0 0
regulation of S phase of mitotic cell cycle -0.011 0.003 -9999 0 -10000 0 0
CDKN1A -0.008 0.007 -9999 0 -10000 0 0
KAT2B 0.027 0.006 -9999 0 -10000 0 0
BAX 0.027 0.008 -9999 0 -10000 0 0
FOXO3 -0.005 0.002 -9999 0 -10000 0 0
FOXO1 0.027 0.006 -9999 0 -10000 0 0
FOXO4 0.013 0.006 -9999 0 -10000 0 0
response to UV 0 0 -9999 0 -10000 0 0
XRCC6 0.025 0.008 -9999 0 -10000 0 0
TAT 0.018 0.022 -9999 0 -10000 0 0
mol:Lysophosphatidic acid 0 0 -9999 0 -10000 0 0
MYOD1 -0.011 0.011 -9999 0 -10000 0 0
PPARGC1A 0.007 0.11 -9999 0 -0.66 6 6
FHL2 0.027 0.008 -9999 0 -10000 0 0
response to nutrient levels 0 0 -9999 0 -10000 0 0
KU70/SIRT1 0.036 0.012 -9999 0 -10000 0 0
HIST2H4A 0.011 0.003 -9999 0 -10000 0 0
SIRT1/FOXO3a 0.024 0.029 -9999 0 -10000 0 0
SIRT1 0.025 0.003 -9999 0 -10000 0 0
response to hypoxia 0 0 -9999 0 -10000 0 0
SIRT1/MEF2D/HDAC4 0.05 0.023 -9999 0 -10000 0 0
SIRT1/Histone H1b 0.019 0.053 -9999 0 -0.21 4 4
apoptosis -0.048 0.018 -9999 0 -10000 0 0
SIRT1/PGC1A 0.021 0.077 -9999 0 -0.43 6 6
p53/SIRT1 0.03 0.012 -9999 0 -10000 0 0
SIRT1/FOXO4 0.024 0.041 -9999 0 -10000 0 0
FOXO1/FHL2/SIRT1 0.048 0.015 -9999 0 -10000 0 0
HIST1H1E 0.012 0.007 -9999 0 -10000 0 0
SIRT1/p300 0.035 0.012 -9999 0 -10000 0 0
muscle cell differentiation -0.029 0.012 -9999 0 -10000 0 0
TP53 0.023 0.008 -9999 0 -10000 0 0
KU70/SIRT1/BAX 0.049 0.018 -9999 0 -10000 0 0
CREBBP 0.025 0.008 -9999 0 -10000 0 0
MEF2D 0.027 0.005 -9999 0 -10000 0 0
HIV-1 Tat/SIRT1 0.034 0.016 -9999 0 -10000 0 0
ACSS2 0.011 0.003 -9999 0 -10000 0 0
SIRT1/PCAF/MYOD 0.029 0.012 -9999 0 -10000 0 0
TRAIL signaling pathway

Figure S121.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S121.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TNFSF10 0.027 0.005 -10000 0 -10000 0 0
positive regulation of NF-kappaB transcription factor activity 0.039 0.011 -10000 0 -10000 0 0
MAP2K4 0.023 0.042 -10000 0 -10000 0 0
IKBKB 0.027 0.005 -10000 0 -10000 0 0
TNFRSF10B 0.026 0.011 -10000 0 -10000 0 0
TNFRSF10A 0.027 0.006 -10000 0 -10000 0 0
SMPD1 0.014 0.005 -10000 0 -10000 0 0
IKBKG 0.028 0.002 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
TNFRSF10D 0.027 0.006 -10000 0 -10000 0 0
TRAIL/TRAILR2 0.038 0.013 -10000 0 -10000 0 0
TRAIL/TRAILR3 0.031 0.043 -10000 0 -0.5 1 1
TRAIL/TRAILR1 0.039 0.011 -10000 0 -10000 0 0
TRAIL/TRAILR4 0.039 0.011 -10000 0 -10000 0 0
TRAIL/TRAILR1/DAP3/GTP 0.049 0.017 -10000 0 -10000 0 0
IKK complex 0.025 0.032 -10000 0 -10000 0 0
RIPK1 0.027 0.006 -10000 0 -10000 0 0
response to oxidative stress 0 0 -10000 0 -10000 0 0
DAP3/GTP 0.02 0.004 -10000 0 -10000 0 0
MAPK3 0.012 0.004 -10000 0 -10000 0 0
MAP3K1 0.028 0.021 -10000 0 -10000 0 0
TRAILR4 (trimer) 0.027 0.006 -10000 0 -10000 0 0
TRADD 0.026 0.007 -10000 0 -10000 0 0
TRAILR1 (trimer) 0.027 0.006 -10000 0 -10000 0 0
TRAIL/TRAILR1/FADD/TRADD/RIP/TRAF2 0.026 0.013 -10000 0 -10000 0 0
CFLAR 0.028 0.004 -10000 0 -10000 0 0
MAPK1 0.012 0.004 -10000 0 -10000 0 0
TRAIL/TRAILR1/FADD/TRADD/RIP 0.071 0.031 -10000 0 -10000 0 0
mol:ceramide 0.014 0.005 -10000 0 -10000 0 0
FADD 0.028 0.004 -10000 0 -10000 0 0
MAPK8 0.016 0.064 0.27 1 -0.32 2 3
TRAF2 0.026 0.007 -10000 0 -10000 0 0
TRAILR3 (trimer) 0.017 0.053 -10000 0 -0.66 1 1
CHUK 0.028 0.003 -10000 0 -10000 0 0
TRAIL/TRAILR1/FADD 0.052 0.017 -10000 0 -10000 0 0
DAP3 0.027 0.005 -10000 0 -10000 0 0
CASP10 0.012 0.025 -10000 0 -10000 0 0
JNK cascade 0.039 0.011 -10000 0 -10000 0 0
TRAIL (trimer) 0.027 0.005 -10000 0 -10000 0 0
TNFRSF10C 0.017 0.053 -10000 0 -0.66 1 1
TRAIL/TRAILR1/DAP3/GTP/FADD 0.059 0.022 -10000 0 -10000 0 0
TRAIL/TRAILR2/FADD 0.051 0.018 -10000 0 -10000 0 0
cell death 0.014 0.005 -10000 0 -10000 0 0
TRAIL/TRAILR2/FADD/TRADD/RIP/TRAF2 0.026 0.013 -10000 0 -10000 0 0
TRAILR2 (trimer) 0.026 0.011 -10000 0 -10000 0 0
CASP8 0.01 0.043 -10000 0 -0.6 1 1
negative regulation of caspase activity 0 0 -10000 0 -10000 0 0
TRAIL/TRAILR2/FADD/TRADD/RIP 0.071 0.031 -10000 0 -10000 0 0
Paxillin-dependent events mediated by a4b1

Figure S122.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S122.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CRKL 0.026 0.008 -9999 0 -9999 0 0
Rac1/GDP 0.02 0.014 -9999 0 -9999 0 0
DOCK1 0.028 0.003 -9999 0 -9999 0 0
ITGA4 0.028 0.004 -9999 0 -9999 0 0
RAC1 0.022 0.011 -9999 0 -9999 0 0
alpha4/beta7 Integrin 0.04 0.009 -9999 0 -9999 0 0
mol:GTP 0 0 -9999 0 -9999 0 0
CRK 0.026 0.008 -9999 0 -9999 0 0
alpha4/beta1 Integrin 0.055 0.012 -9999 0 -9999 0 0
alpha4/beta7 Integrin/Paxillin 0.044 0.012 -9999 0 -9999 0 0
lamellipodium assembly 0.021 0.038 -9999 0 -9999 0 0
PIK3CA 0.027 0.005 -9999 0 -9999 0 0
PI3K 0.04 0.009 -9999 0 -9999 0 0
ARF6 0.026 0.007 -9999 0 -9999 0 0
TLN1 0.027 0.006 -9999 0 -9999 0 0
PXN 0.013 0.003 -9999 0 -9999 0 0
PIK3R1 0.027 0.004 -9999 0 -9999 0 0
ARF6/GTP 0.051 0.023 -9999 0 -9999 0 0
cell adhesion 0.054 0.02 -9999 0 -9999 0 0
CRKL/CBL 0.037 0.013 -9999 0 -9999 0 0
alpha4/beta1 Integrin/Paxillin 0.043 0.014 -9999 0 -9999 0 0
ITGB1 0.027 0.005 -9999 0 -9999 0 0
ITGB7 0.027 0.005 -9999 0 -9999 0 0
ARF6/GDP 0.023 0.012 -9999 0 -9999 0 0
alpha4/beta1 Integrin/Paxillin/VCAM1 0.054 0.023 -9999 0 -9999 0 0
p130Cas/Crk/Dock1 0.049 0.02 -9999 0 -9999 0 0
VCAM1 0.017 0.029 -9999 0 -9999 0 0
alpha4/beta1 Integrin/Paxillin/Talin 0.056 0.02 -9999 0 -9999 0 0
alpha4/beta1 Integrin/Paxillin/GIT1 0.055 0.021 -9999 0 -9999 0 0
BCAR1 0.026 0.007 -9999 0 -9999 0 0
mol:GDP -0.053 0.021 -9999 0 -9999 0 0
CBL 0.027 0.005 -9999 0 -9999 0 0
PRKACA 0.028 0.002 -9999 0 -9999 0 0
GIT1 0.026 0.007 -9999 0 -9999 0 0
alpha4/beta1 Integrin/Paxillin/Talin/Actin Cytoskeleton 0.056 0.02 -9999 0 -9999 0 0
Rac1/GTP 0.021 0.04 -9999 0 -9999 0 0
Atypical NF-kappaB pathway

Figure S123.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S123.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL3/RelA 0.041 0.008 -9999 0 -10000 0 0
FBXW11 0.027 0.005 -9999 0 -10000 0 0
NF kappa B1 p50/c-Rel 0.026 0.033 -9999 0 -0.43 1 1
NF kappa B1 p50/RelA/I kappa B alpha 0.018 0.066 -9999 0 -10000 0 0
NFKBIA 0.016 0.031 -9999 0 -0.24 1 1
MAPK14 0.027 0.006 -9999 0 -10000 0 0
NF kappa B1 p105/p50 0.028 0.01 -9999 0 -10000 0 0
ARRB2 0.013 0.006 -9999 0 -10000 0 0
REL 0.023 0.048 -9999 0 -0.66 1 1
response to oxidative stress 0 0 -9999 0 -10000 0 0
BCL3/NF kappa B1 p50 0.028 0.01 -9999 0 -10000 0 0
response to UV 0 0 -9999 0 -10000 0 0
NF kappa B1 p105/RelA 0.029 0.008 -9999 0 -10000 0 0
PIK3CA 0.027 0.005 -9999 0 -10000 0 0
NF kappa B1 p50 dimer 0.021 0.006 -9999 0 -10000 0 0
PIK3R1 0.027 0.004 -9999 0 -10000 0 0
NFKB1 0.013 0.004 -9999 0 -10000 0 0
RELA 0.028 0.002 -9999 0 -10000 0 0
positive regulation of anti-apoptosis 0.014 0.038 -9999 0 -0.23 1 1
NF kappa B1 p50/RelA/I kappa B alpha/beta Arrestin2 0.018 0.071 -9999 0 -10000 0 0
SRC 0.026 0.009 -9999 0 -10000 0 0
PI3K 0.04 0.009 -9999 0 -10000 0 0
NF kappa B1 p50/RelA 0.014 0.038 -9999 0 -0.23 1 1
IKBKB 0.027 0.005 -9999 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.027 0.005 -9999 0 -10000 0 0
SYK 0.023 0.047 -9999 0 -0.66 1 1
I kappa B alpha/PIK3R1 0.012 0.068 -9999 0 -0.32 2 2
cell death 0.017 0.068 -9999 0 -10000 0 0
NF kappa B1 p105/c-Rel 0.026 0.033 -9999 0 -0.43 1 1
LCK 0.024 0.017 -9999 0 -10000 0 0
BCL3 0.027 0.008 -9999 0 -10000 0 0
HIV-1 Nef: Negative effector of Fas and TNF-alpha

Figure S124.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S124.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BAG4 0.027 0.006 -10000 0 -10000 0 0
Caspase 8 (4 units) 0.041 0.039 -10000 0 -10000 0 0
NEF 0 0.008 -10000 0 -10000 0 0
NFKBIA 0.025 0.014 -10000 0 -10000 0 0
BIRC3 0.015 0.025 -10000 0 -10000 0 0
CYCS 0.006 0.025 -10000 0 -10000 0 0
RIPK1 0.027 0.006 -10000 0 -10000 0 0
CD247 0.022 0.027 -10000 0 -10000 0 0
MAP2K7 0.03 0.085 -10000 0 -0.46 3 3
protein ubiquitination 0.041 0.1 0.39 7 -0.31 4 11
CRADD 0.027 0.005 -10000 0 -10000 0 0
DAXX 0.027 0.006 -10000 0 -10000 0 0
FAS 0.028 0.003 -10000 0 -10000 0 0
BID 0.014 0.029 -10000 0 -10000 0 0
NF-kappa-B/RelA/I kappa B alpha 0.052 0.031 -10000 0 -10000 0 0
TRADD 0.026 0.007 -10000 0 -10000 0 0
MAP3K5 0.027 0.005 -10000 0 -10000 0 0
CFLAR 0.028 0.004 -10000 0 -10000 0 0
FADD 0.028 0.004 -10000 0 -10000 0 0
NF-kappa-B/RelA/I kappa B alpha/ubiquitin 0.052 0.031 -10000 0 -10000 0 0
MAPK8 0.022 0.091 -10000 0 -0.46 2 2
APAF1 0.027 0.006 -10000 0 -10000 0 0
TRAF1 0.027 0.007 -10000 0 -10000 0 0
TRAF2 0.026 0.007 -10000 0 -10000 0 0
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG 0.021 0.033 -10000 0 -10000 0 0
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP1/cIAP2/TRAF1/TRAF2/Ask1/RAIDD 0.009 0.079 -10000 0 -0.4 4 4
CHUK 0.034 0.093 0.34 3 -0.34 4 7
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 0.077 0.024 -10000 0 -10000 0 0
TCRz/NEF 0.018 0.024 -10000 0 -10000 0 0
TNF 0.014 0.07 -10000 0 -0.66 2 2
FASLG 0.01 0.029 -10000 0 -10000 0 0
NFKB1 0.025 0.014 -10000 0 -10000 0 0
TNFR1A/BAG4/TNF-alpha 0.041 0.054 -10000 0 -0.43 2 2
CASP6 0.028 0.12 -10000 0 -0.49 7 7
CASP7 0.029 0.06 -10000 0 -10000 0 0
RELA 0.027 0.013 -10000 0 -10000 0 0
CASP2 0.023 0.011 -10000 0 -10000 0 0
CASP3 0.024 0.07 -10000 0 -10000 0 0
TNFRSF1A 0.027 0.007 -10000 0 -10000 0 0
TNFR1A/BAG4 0.038 0.012 -10000 0 -10000 0 0
CASP8 0.028 0.004 -10000 0 -10000 0 0
CASP9 0.026 0.008 -10000 0 -10000 0 0
MAP3K14 0.027 0.087 -10000 0 -0.37 4 4
APAF-1/Caspase 9 0.038 0.057 -10000 0 -10000 0 0
BCL2 0.02 0.084 -10000 0 -0.49 1 1
Glypican 2 network

Figure S125.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S125.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MDK 0.004 0.042 -9999 0 -9999 0 0
GPC2 -0.003 0.042 -9999 0 -9999 0 0
GPC2/Midkine 0.001 0.046 -9999 0 -9999 0 0
neuron projection morphogenesis 0.001 0.046 -9999 0 -9999 0 0
Sumoylation by RanBP2 regulates transcriptional repression

Figure S126.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S126.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.026 0.007 -9999 0 -10000 0 0
Ran/GTP/Exportin 1/HDAC4 0.003 0.015 -9999 0 -10000 0 0
MDM2/SUMO1 0.035 0.042 -9999 0 -10000 0 0
HDAC4 0.025 0.026 -9999 0 -0.34 1 1
Ran/GTP/Exportin 1/HDAC1 0.004 0.01 -9999 0 -10000 0 0
SUMO1 0.028 0.004 -9999 0 -10000 0 0
NPC/RanGAP1/SUMO1 0.011 0.01 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
XPO1 0.008 0.016 -9999 0 -10000 0 0
EntrezGene:23636 0 0 -9999 0 -10000 0 0
RAN 0.027 0.006 -9999 0 -10000 0 0
EntrezGene:8021 0 0 -9999 0 -10000 0 0
RANBP2 0.028 0.003 -9999 0 -10000 0 0
SUMO1/HDAC4 0.037 0.043 -9999 0 -10000 0 0
SUMO1/HDAC1 0.04 0.037 -9999 0 -10000 0 0
RANGAP1 0.025 0.008 -9999 0 -10000 0 0
MDM2/SUMO1/SUMO1 0.062 0.026 -9999 0 -10000 0 0
NPC/RanGAP1/SUMO1/RanBP2/Ubc9 0.013 0.006 -9999 0 -10000 0 0
Ran/GTP 0.023 0.036 -9999 0 -10000 0 0
EntrezGene:23225 0 0 -9999 0 -10000 0 0
MDM2 0.027 0.006 -9999 0 -10000 0 0
UBE2I 0.025 0.008 -9999 0 -10000 0 0
Ran/GTP/Exportin 1 0.021 0.035 -9999 0 -10000 0 0
NPC 0.016 0.002 -9999 0 -10000 0 0
PIAS2 0.026 0.008 -9999 0 -10000 0 0
PIAS1 0.028 0.004 -9999 0 -10000 0 0
EntrezGene:9972 0 0 -9999 0 -10000 0 0
IL2 signaling events mediated by STAT5

Figure S127.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S127.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GAB2 0.028 0.003 -10000 0 -10000 0 0
ELF1 0.026 0.022 -10000 0 -10000 0 0
CCNA2 0.012 0.035 -10000 0 -10000 0 0
PIK3CA 0.028 0.005 -10000 0 -10000 0 0
JAK3 0.007 0.041 -10000 0 -10000 0 0
PIK3R1 0.028 0.004 -10000 0 -10000 0 0
JAK1 0.027 0.007 -10000 0 -10000 0 0
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K 0.022 0.086 -10000 0 -0.42 3 3
SHC1 0.028 0.005 -10000 0 -10000 0 0
SP1 0.022 0.026 -10000 0 -10000 0 0
IL2RA 0.01 0.025 -10000 0 -10000 0 0
IL2RB 0.015 0.031 -10000 0 -10000 0 0
SOS1 0.028 0.004 -10000 0 -10000 0 0
IL2RG 0.025 0.018 -10000 0 -10000 0 0
G1/S transition of mitotic cell cycle 0.04 0.098 0.4 8 -10000 0 8
PTPN11 0.027 0.006 -10000 0 -10000 0 0
CCND2 0.008 0.027 -10000 0 -10000 0 0
LCK 0.024 0.017 -10000 0 -10000 0 0
GRB2 0.026 0.008 -10000 0 -10000 0 0
IL2 0 0.023 -10000 0 -10000 0 0
CDK6 0.023 0.011 -10000 0 -10000 0 0
CCND3 0.029 0.084 -10000 0 -10000 0 0
Rapid glucocorticoid signaling

Figure S128.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S128.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Gs family/GDP/Gbeta gamma 0.04 0.034 -10000 0 -0.37 1 1
MAPK9 0.007 0.001 -10000 0 -10000 0 0
adrenocorticotropin secretion -0.003 0.01 -10000 0 -10000 0 0
GNB1/GNG2 0.034 0.012 -10000 0 -10000 0 0
GNB1 0.025 0.008 -10000 0 -10000 0 0
regulation of calcium ion transport via voltage-gated calcium channel activity 0 0 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
MAPK14 0.007 0.002 -10000 0 -10000 0 0
Gs family/GTP 0.015 0.028 -10000 0 -0.39 1 1
EntrezGene:2778 0 0 -10000 0 -10000 0 0
vasopressin secretion 0 0 -10000 0 -10000 0 0
G-protein coupled receptor activity 0 0 -10000 0 -10000 0 0
ChemicalAbstracts:86-01-1 0 0 -10000 0 -10000 0 0
glutamate secretion 0.001 0.007 0.096 1 -10000 0 1
GNAL 0.023 0.048 -10000 0 -0.66 1 1
GNG2 0.026 0.007 -10000 0 -10000 0 0
CRH 0.002 0.025 -10000 0 -10000 0 0
mol:cortisol 0 0 -10000 0 -10000 0 0
MAPK8 0.001 0.05 -10000 0 -0.36 4 4
MAPK11 0.007 0.002 -10000 0 -10000 0 0
p38 MAPK signaling pathway

Figure S129.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S129.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TRAF6/ASK1 0.02 0.014 -10000 0 -10000 0 0
TRAF2/ASK1 0.035 0.01 -10000 0 -10000 0 0
ATM 0.027 0.005 -10000 0 -10000 0 0
MAP2K3 0.037 0.073 0.27 7 -10000 0 7
response to stress 0 0 -10000 0 -10000 0 0
MAP2K6 0.032 0.063 0.24 4 -10000 0 4
hyperosmotic response 0 0 -10000 0 -10000 0 0
response to oxidative stress 0 0 -10000 0 -10000 0 0
GADD45G 0.02 0.067 -10000 0 -0.66 2 2
TXN 0.007 0.003 -10000 0 -10000 0 0
CALM1 0.026 0.007 -10000 0 -10000 0 0
GADD45A 0.026 0.007 -10000 0 -10000 0 0
GADD45B 0.025 0.047 -10000 0 -0.66 1 1
MAP3K1 0.027 0.004 -10000 0 -10000 0 0
MAP3K6 0.026 0.008 -10000 0 -10000 0 0
MAP3K7 0.027 0.005 -10000 0 -10000 0 0
MAP3K4 0.027 0.005 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
ASK1/ASK2 0.037 0.013 -10000 0 -10000 0 0
TAK1/TAB family 0.001 0.018 -10000 0 -10000 0 0
RAC1/OSM/MEKK3 0.04 0.024 -10000 0 -10000 0 0
TRAF2 0.026 0.007 -10000 0 -10000 0 0
RAC1/OSM/MEKK3/MKK3 0.028 0.049 -10000 0 -10000 0 0
TRAF6 0.007 0.001 -10000 0 -10000 0 0
RAC1 0.022 0.011 -10000 0 -10000 0 0
mol:LPS 0 0 -10000 0 -10000 0 0
CAMK2B 0.002 0.096 -10000 0 -0.66 4 4
CCM2 0.023 0.011 -10000 0 -10000 0 0
CaM/Ca2+/CAMKIIB 0.014 0.066 -10000 0 -0.43 4 4
MAPK11 0.025 0.009 -10000 0 -10000 0 0
response to DNA damage stimulus 0 0 -10000 0 -10000 0 0
CaM/Ca2+/CAMKIIB/ASK1 0.024 0.065 -10000 0 -0.39 4 4
OSM/MEKK3 0.031 0.018 -10000 0 -10000 0 0
TAOK1 0.01 0.039 -10000 0 -0.38 2 2
TAOK2 0.014 0.005 -10000 0 -10000 0 0
TAOK3 0.014 0.004 -10000 0 -10000 0 0
MAP3K7IP1 0 0 -10000 0 -10000 0 0
MAPK14 0.027 0.006 -10000 0 -10000 0 0
MAP3K7IP2 0 0 -10000 0 -10000 0 0
MAP3K5 0.027 0.005 -10000 0 -10000 0 0
MAP3K10 0.028 0.003 -10000 0 -10000 0 0
MAP3K3 0.026 0.008 -10000 0 -10000 0 0
TRX/ASK1 0.022 0.022 -10000 0 -10000 0 0
GADD45/MTK1/MTK1 0.053 0.056 -10000 0 -0.38 3 3
Arf1 pathway

Figure S130.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S130.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
coatomer protein complex 0.012 0.032 0.21 3 -10000 0 3
EntrezGene:79658 0 0 -10000 0 -10000 0 0
ARF1/GDP/Membrin/GBF1/p115/Brefeldin A 0.007 0.044 -10000 0 -0.23 5 5
AP2 0.04 0.009 -10000 0 -10000 0 0
mol:DAG 0 0 -10000 0 -10000 0 0
Arfaptin 2/Rac/GTP 0.03 0.017 -10000 0 -10000 0 0
CLTB 0.027 0.006 -10000 0 -10000 0 0
coatomer protein complex/ARF1/GTP/ER cargo protein 0.019 0.007 -10000 0 -10000 0 0
CD4 0.023 0.02 -10000 0 -10000 0 0
CLTA 0.027 0.006 -10000 0 -10000 0 0
mol:GTP -0.001 0.002 -10000 0 -10000 0 0
ARFGAP1 0.007 0.002 -10000 0 -10000 0 0
mol:PI-4-5-P2 0.006 0.006 -10000 0 -10000 0 0
ARF1/GTP 0.034 0.012 -10000 0 -10000 0 0
coatomer protein complex/ARF1/GTP/ARF-GAP1/ER cargo protein 0.01 0.008 -10000 0 -10000 0 0
mol:Choline 0.006 0.006 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
ARF1 0.027 0.007 -10000 0 -10000 0 0
DDEF1 0.004 0.006 -10000 0 -10000 0 0
ARF1/GDP 0.002 0.018 -10000 0 -10000 0 0
AP2M1 0.027 0.005 -10000 0 -10000 0 0
EntrezGene:1313 0 0 -10000 0 -10000 0 0
actin filament polymerization 0.01 0.007 -10000 0 -10000 0 0
Rac/GTP 0.017 0.009 -10000 0 -10000 0 0
ARF1/GTP/GGA3/ARF-GAP1 0.035 0.016 -10000 0 -10000 0 0
ARFIP2 0.024 0.015 -10000 0 -10000 0 0
COPA 0.027 0.006 -10000 0 -10000 0 0
RAC1 0.022 0.011 -10000 0 -10000 0 0
ARF1/GTP/coatomer protein complex 0.004 0.062 -10000 0 -0.34 5 5
ARF1/GTP/ARHGAP10 0.019 0.006 -10000 0 -10000 0 0
GGA3 0.026 0.008 -10000 0 -10000 0 0
ARF1/GTP/Membrin 0.03 0.016 -10000 0 -10000 0 0
AP2A1 0.028 0.003 -10000 0 -10000 0 0
coatomer protein complex/ARF1/GTP/ARF-GAP1 0.013 0.023 -10000 0 -0.21 1 1
ARF1/GDP/Membrin 0.029 0.015 -10000 0 -10000 0 0
Arfaptin 2/Rac/GDP 0.03 0.017 -10000 0 -10000 0 0
CYTH2 0.029 0.006 -10000 0 -10000 0 0
ARF1/GTP/GGA3 0.034 0.014 -10000 0 -10000 0 0
mol:ATP 0 0 -10000 0 -10000 0 0
Rac/GDP 0.017 0.008 -10000 0 -10000 0 0
mol:Brefeldin A 0 0 -10000 0 -10000 0 0
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex/Coatomer protein complex/ARF1/GTP 0.015 0.029 -10000 0 -10000 0 0
PLD2 0.006 0.006 -10000 0 -10000 0 0
ARF-GAP1/v-SNARE 0.007 0.002 -10000 0 -10000 0 0
PIP5K1A 0.006 0.006 -10000 0 -10000 0 0
ARF1/GTP/Membrin/GBF1/p115 0.026 0.024 -10000 0 -10000 0 0
mol:Phosphatic acid 0 0 -10000 0 -10000 0 0
mol:Phosphatidic acid 0.006 0.006 -10000 0 -10000 0 0
KDEL Receptor/Ligand/ARF-GAP1 0.007 0.002 -10000 0 -10000 0 0
GOSR2 0.012 0.006 -10000 0 -10000 0 0
USO1 0.006 0.045 -10000 0 -0.31 4 4
GBF1 0.009 0.031 -10000 0 -0.31 2 2
ARF1/GTP/Arfaptin 2 0.038 0.013 -10000 0 -10000 0 0
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex 0.048 0.024 -10000 0 -10000 0 0
Alternative NF-kappaB pathway

Figure S131.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S131.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IKK alpha homodimer 0.038 0.012 -9999 0 -9999 0 0
FBXW11 0.027 0.005 -9999 0 -9999 0 0
proteasomal ubiquitin-dependent protein catabolic process 0 0 -9999 0 -9999 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.027 0.005 -9999 0 -9999 0 0
CHUK 0.028 0.003 -9999 0 -9999 0 0
NF kappa B2 p100/RelB 0.074 0.028 -9999 0 -9999 0 0
NFKB1 0.027 0.006 -9999 0 -9999 0 0
MAP3K14 0.026 0.008 -9999 0 -9999 0 0
NF kappa B1 p50/RelB 0.039 0.01 -9999 0 -9999 0 0
RELB 0.028 0.003 -9999 0 -9999 0 0
NFKB2 0.028 0.003 -9999 0 -9999 0 0
NF kappa B2 p52/RelB 0.037 0.006 -9999 0 -9999 0 0
regulation of B cell activation 0.037 0.006 -9999 0 -9999 0 0
Inferred Pathway Levels Matrix

Table 3.  Get Full Table First 10 out of 7202 rows and 4 out of 211 columns in the PARADIGM inferred pathway levels matrix.

pid_entity TCGA.Y8.A898 TCGA.Y8.A897 TCGA.Y8.A896 TCGA.Y8.A895
109_MAP3K5 0.031 0.031 0.019 0.031
47_PPARGC1A 0.028 0.028 0.028 0.028
105_BMP4 0.028 0.028 0.028 0.028
105_BMP6 0.028 0.028 0.028 0.028
105_BMP7 0.028 0.028 0.028 -0.66
105_BMP2 0.028 0.028 0.028 0.028
131_RELN/VLDLR 0.072 0.072 0.072 0.054
30_TGFB1/TGF beta receptor Type II 0.028 0.028 0.028 0.033
84_STAT5B -0.16 -0.046 -0.37 -0.16
84_STAT5A -0.16 -0.046 -0.37 -0.16
Methods & Data
Input

  • Expression Data Normalization = Normal controls were used to median center the expression data used in this analysis.

  • mRNASeq Expression File Used = /xchip/cga/gdac-prod/tcga-gdac/jobResults/mRNAseq_preprocessor/KIRP-TP/9830104/KIRP-TP.uncv2.mRNAseq_RSEM_normalized_log2_PARADIGM.txt

  • Copy Number File Used = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_Gistic2/KIRP-TP/10005967/Gistic2_Analysis_10006230/all_data_by_genes.txt

Data Sets and Pathway Interactions

Both copy number and expression data are incorporated into PARADIGM's inference. Whenever normal tissue controls are available for analysis in the expression data, each patient's gene-value is normalized by subtracting the gene's median level observed in the normal control. Copy number data is also normalized to reflect the difference in copy number between a gene's levels detected in tumor versus control (e.g. blood normal). The collection of pathways used by PARADIGM includes those from NCI-PID on September 15, 2009 containing 131 pathways, 11,563 interactions, and 7,204 entities. All gene identifiers were translated into HUGO standard identifiers wherever possible. We refer to molecular entities as "concepts," which include gene products such as proteins and miRNAs, small molecules, protein complexes, and abstract concepts. Each concept is represented as "node" in PARADIGM's graphical model. The abstract concepts correspond to general cellular processes (such as "apoptosis" or "DNA damage response") and families of genes that share functional activity such as the RAS family of signal transducers. Various types of concept-concept interactions are included in the pathways including protein-protein interactions, transcriptional regulatory interactions, and protein modifications such as phosphorylation and ubiquitinylation interactions.

Pathway Inference Method

The PARADIGM algorithm (described in PMID: 20529912) assigns an integrated pathway level (IPL) reflecting the activity of a concept determined through a belief propagation strategy. The belief propagation is given the copy number and gene expression measurements of all of the genes and iteratively updates hidden states reflecting the activities of all of the genes in a pathway so as to maximize the likelihood of the observed data given the interactions in the pathway. In the end, the inferred level of a concept reflects both the data observed for the concept and the neighborhood of activity surrounding the concept.

Determining significantly altered levels

The significance of the IPL obtained for each concept in each patient sample is assessed using a permutation analysis. Importantly, the permutation analysis preserves data tuples so as to preserve any implicit correlations between the different data modalities. For example, genes that are deleted have concomitantly lower expression levels. Preserving the copy number and expression pairs therefore retains this data property. The simulation therefore makes "null samples" by permuting data tuples across all of the genes in the genome so that each gene in a null sample is associated with a random tuple of another gene with equal probability. This approach has the added benefit of preserving the pathway structure so that every observed IPL can be compared to a distribution of random IPLs derived from exactly the same interaction context. PARADIGM inferences are then obtained for 1000 "null" patients and serve as a background distribution to contrast the observed IPLs against. Pathway concepts are excluded from further analysis if they did not obtain a minimum IPL of 0.5 in any patient sample both observed or simulated.

An IPL I(i,j) for concept i in sample j, is considered to be deviated if its absolute level is two standard deviations from the average level observed for concept i in the 1000 null samples. The degree to which a concept has significantly altered levels across a patient cohort is summarized in the proportion of deviated samples (PDS) score. For example, a protein with a PDS of 0.10 reflects that the protein's level of activity was inferred to be significantly higher or lower in tumors compared to normal in 10% of the patient samples. An average PDS for a pathway is also reported by computing the mean PDS over all concepts in the pathway.

Download Results

In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.

References
[2] Charles J. Vaske, Stephen C. Benz, J. Zachary Sanborn, Dent Earl, Christopher Szeto, Jingchun Zhu, David Haussler, and Joshua M. Stuart, Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM, Bioinformatics 12(26):237-245 (2010)
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