GSEA Class2: Canonical Pathways enriched in each subtypes of mRNAseq_cNMF in PAAD-TP

Pancreatic Adenocarcinoma (Primary solid tumor)

28 January 2016 | analyses__2016_01_28

Maintainer Information

Citation Information

Maintained by Juok Cho (Broad Institute)

Cite as Broad Institute TCGA Genome Data Analysis Center (2016): GSEA Class2: Canonical Pathways enriched in each subtypes of mRNAseq_cNMF in PAAD-TP. Broad Institute of MIT and Harvard. doi:10.7908/C1H70F83

+ Overview

+ Introduction

+ Summary

Table 1. Get Full Table basic data info

basic data info
Number of Gene Sets: 730
Number of samples: 178
Original number of Gene Sets: 1320
Maximum gene set size: 933

Table 2. Get Full Table pheno data info

phenotype info
pheno.type: 1 - 5 :[ clus1 ] 39
pheno.type: 2 - 5 :[ clus2 ] 26
pheno.type: 3 - 5 :[ clus3 ] 43
pheno.type: 4 - 5 :[ clus4 ] 40
pheno.type: 5 - 5 :[ clus5 ] 30

For the expression subtypes of 18475 genes in 179 samples, GSEA found enriched gene sets in each cluster using 178 gene sets in MSigDB canonical pathways. Top enriched gene sets are listed as below.

clus1

Top enriched gene sets are KEGG PENTOSE AND GLUCURONATE INTERCONVERSIONS, KEGG FRUCTOSE AND MANNOSE METABOLISM, KEGG STEROID HORMONE BIOSYNTHESIS, KEGG RETINOL METABOLISM, KEGG PORPHYRIN AND CHLOROPHYLL METABOLISM, KEGG AMINOACYL TRNA BIOSYNTHESIS, KEGG METABOLISM OF XENOBIOTICS BY CYTOCHROME P450, KEGG DRUG METABOLISM CYTOCHROME P450, KEGG DRUG METABOLISM OTHER ENZYMES, KEGG BASE EXCISION REPAIR

And common core enriched genes are UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A3, UGT2B10

clus2

Top enriched gene sets are KEGG LYSINE DEGRADATION, KEGG GLYCOSYLPHOSPHATIDYLINOSITOL GPI ANCHOR BIOSYNTHESIS, BIOCARTA BIOPEPTIDES PATHWAY, BIOCARTA CHREBP2 PATHWAY, SIG CD40PATHWAYMAP, PID P38 MKK3 6PATHWAY, PID LKB1 PATHWAY, PID LIS1PATHWAY, PID HEDGEHOG GLIPATHWAY, REACTOME TRANS GOLGI NETWORK VESICLE BUDDING

And common core enriched genes are MLXIPL, PKLR, PRKAR2B, OGDHL, PIPOX, GCK, PPP2R2B, PPP2R2C, PPP2R3B, CACNG2

clus3

Top enriched gene sets are KEGG DNA REPLICATION, KEGG CELL CYCLE, KEGG P53 SIGNALING PATHWAY, BIOCARTA RACCYCD PATHWAY, PID P73PATHWAY, PID E2F PATHWAY, PID ATR PATHWAY, PID FRA PATHWAY, PID MYC ACTIVPATHWAY, PID PLK1 PATHWAY

And common core enriched genes are CCNB1, CDK1, CDK2, CCNA2, CCNB2, PLK1, CCNE2, CDK6, CHEK1, AZI1

clus4

Top enriched gene sets are KEGG FATTY ACID METABOLISM, KEGG SELENOAMINO ACID METABOLISM, KEGG GLUTATHIONE METABOLISM, KEGG GLYCEROLIPID METABOLISM, KEGG PROPANOATE METABOLISM, KEGG ENDOCYTOSIS, SIG PIP3 SIGNALING IN CARDIAC MYOCTES, SIG CHEMOTAXIS, SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES, PID INSULIN PATHWAY

And common core enriched genes are ERBB4, F2RL2, CBS, CTH, GGT1, GGT6, MAT1A, EGF, FOXO3, NRG2

clus5

Top enriched gene sets are KEGG PURINE METABOLISM, KEGG GLYCOSAMINOGLYCAN BIOSYNTHESIS HEPARAN SULFATE, KEGG ABC TRANSPORTERS, KEGG MAPK SIGNALING PATHWAY, KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION, KEGG PHOSPHATIDYLINOSITOL SIGNALING SYSTEM, KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION, KEGG OOCYTE MEIOSIS, KEGG MTOR SIGNALING PATHWAY, KEGG APOPTOSIS

And common core enriched genes are FYN, HCK, LCK, PSMA8, SLC2A4, BLK, PIK3CD, AP1S2, APOBEC3G, CD247

+ Results

+ Subtype clus1 enriched pathways

Table 3. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus1. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
KEGG PENTOSE AND GLUCURONATE INTERCONVERSIONS	26	genes.ES.table	0.81	1.7	0.0065	1	0.81	0.58	0.066	0.54	0.51	0.3
KEGG FRUCTOSE AND MANNOSE METABOLISM	34	genes.ES.table	0.44	1.4	0.1	1	1	0.32	0.16	0.27	0.95	0.47
KEGG STEROID HORMONE BIOSYNTHESIS	50	genes.ES.table	0.61	1.4	0.043	1	0.99	0.46	0.068	0.43	0.91	0.45
KEGG RETINOL METABOLISM	59	genes.ES.table	0.72	1.7	0	1	0.85	0.64	0.13	0.56	0.5	0.29
KEGG PORPHYRIN AND CHLOROPHYLL METABOLISM	38	genes.ES.table	0.64	1.6	0.044	1	0.96	0.34	0.066	0.32	0.63	0.32
KEGG AMINOACYL TRNA BIOSYNTHESIS	41	genes.ES.table	0.41	1.5	0.13	1	0.99	1	0.59	0.41	0.82	0.4
KEGG METABOLISM OF XENOBIOTICS BY CYTOCHROME P450	65	genes.ES.table	0.67	1.5	0.015	0.86	0.97	0.58	0.14	0.51	0.53	0.26
KEGG DRUG METABOLISM CYTOCHROME P450	66	genes.ES.table	0.62	1.4	0.047	1	0.99	0.48	0.082	0.45	0.94	0.46
KEGG DRUG METABOLISM OTHER ENZYMES	47	genes.ES.table	0.71	1.7	0	1	0.78	0.47	0.066	0.44	0.68	0.39
KEGG BASE EXCISION REPAIR	33	genes.ES.table	0.58	1.7	0.054	1	0.76	0.46	0.24	0.35	1	0.56

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	POLE2	POLE2	POLE2	996	0.22	0.051	YES
2	NTHL1	NTHL1	NTHL1	1367	0.18	0.12	YES
3	NEIL3	NEIL3	NEIL3	1476	0.17	0.19	YES
4	MUTYH	MUTYH	MUTYH	1666	0.15	0.25	YES
5	NEIL1	NEIL1	NEIL1	1958	0.13	0.3	YES
6	POLD4	POLD4	POLD4	1971	0.13	0.36	YES
7	PARP3	PARP3	PARP3	2038	0.13	0.41	YES
8	SMUG1	SMUG1	SMUG1	2457	0.11	0.44	YES
9	PARP4	PARP4	PARP4	2590	0.1	0.48	YES
10	POLD3	POLD3	POLD3	2637	0.098	0.52	YES
11	POLE	POLE	POLE	3224	0.078	0.53	YES
12	MPG	MPG	MPG	3485	0.071	0.55	YES
13	POLB	POLB	POLB	3556	0.069	0.58	YES
14	POLL	POLL	POLL	4057	0.056	0.57	YES
15	POLD2	POLD2	POLD2	4437	0.048	0.58	YES
16	POLE4	POLE4	POLE4	4846	0.04	0.57	NO
17	APEX2	APEX2	APEX2	5141	0.034	0.57	NO
18	OGG1	OGG1	OGG1	5434	0.029	0.57	NO
19	PCNA	PCNA	PCNA	6042	0.02	0.55	NO
20	MBD4	MBD4	MBD4	6332	0.016	0.54	NO
21	LIG3	LIG3	LIG3	6371	0.016	0.55	NO
22	POLD1	POLD1	POLD1	6586	0.012	0.54	NO
23	HMGB1	HMGB1	HMGB1	6914	0.0078	0.52	NO
24	UNG	UNG	UNG	6977	0.0071	0.52	NO
25	LIG1	LIG1	LIG1	7154	0.005	0.52	NO
26	APEX1	APEX1	APEX1	7626	-0.0017	0.49	NO
27	TDG	TDG	TDG	7780	-0.0037	0.49	NO
28	XRCC1	XRCC1	XRCC1	7956	-0.006	0.48	NO
29	FEN1	FEN1	FEN1	8038	-0.007	0.48	NO
30	PARP1	PARP1	PARP1	8813	-0.019	0.45	NO
31	POLE3	POLE3	POLE3	8921	-0.021	0.45	NO
32	PARP2	PARP2	PARP2	10309	-0.043	0.4	NO
33	NEIL2	NEIL2	NEIL2	12673	-0.1	0.31	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CYP3A7	CYP3A7	CYP3A7	70	0.56	0.055	YES
2	UGT1A1	UGT1A1	UGT1A1	78	0.55	0.11	YES
3	UGT1A9	UGT1A9	UGT1A9	145	0.48	0.16	YES
4	NAT2	NAT2	NAT2	156	0.47	0.21	YES
5	CYP3A5	CYP3A5	CYP3A5	236	0.42	0.25	YES
6	UGT1A3	UGT1A3	UGT1A3	246	0.41	0.29	YES
7	CYP3A4	CYP3A4	CYP3A4	274	0.4	0.33	YES
8	CYP2A7	CYP2A7	CYP2A7	296	0.39	0.37	YES
9	UGT1A8	UGT1A8	UGT1A8	367	0.36	0.4	YES
10	UGT2B7	UGT2B7	UGT2B7	412	0.34	0.44	YES
11	UGT1A10	UGT1A10	UGT1A10	450	0.33	0.47	YES
12	UGT1A4	UGT1A4	UGT1A4	470	0.33	0.5	YES
13	UGT2B10	UGT2B10	UGT2B10	624	0.29	0.52	YES
14	UGT1A6	UGT1A6	UGT1A6	751	0.27	0.55	YES
15	XDH	XDH	XDH	845	0.25	0.57	YES
16	UGT2A3	UGT2A3	UGT2A3	867	0.24	0.59	YES
17	CYP2A6	CYP2A6	CYP2A6	872	0.24	0.62	YES
18	UGT2B28	UGT2B28	UGT2B28	1015	0.22	0.63	YES
19	UGT1A7	UGT1A7	UGT1A7	1069	0.21	0.65	YES
20	NAT1	NAT1	NAT1	1080	0.21	0.67	YES
21	CES2	CES2	CES2	1134	0.2	0.69	YES
22	UGT2B15	UGT2B15	UGT2B15	1210	0.19	0.71	YES
23	UCK2	UCK2	UCK2	2189	0.12	0.67	NO
24	UGT2B11	UGT2B11	UGT2B11	2269	0.12	0.67	NO
25	TPMT	TPMT	TPMT	2272	0.11	0.69	NO
26	UGT2A1	UGT2A1	UGT2A1	2473	0.1	0.69	NO
27	TK1	TK1	TK1	2723	0.095	0.68	NO
28	ITPA	ITPA	ITPA	3059	0.083	0.67	NO
29	HPRT1	HPRT1	HPRT1	3611	0.068	0.65	NO
30	GUSB	GUSB	GUSB	3708	0.065	0.65	NO
31	UCKL1	UCKL1	UCKL1	4659	0.044	0.6	NO
32	UMPS	UMPS	UMPS	6016	0.02	0.53	NO
33	IMPDH2	IMPDH2	IMPDH2	6031	0.02	0.54	NO
34	GMPS	GMPS	GMPS	7038	0.0064	0.48	NO
35	TK2	TK2	TK2	7463	0.00044	0.46	NO
36	UPP1	UPP1	UPP1	7991	-0.0065	0.43	NO
37	UGT2B4	UGT2B4	UGT2B4	8130	-0.0082	0.42	NO
38	CYP3A43	CYP3A43	CYP3A43	9192	-0.024	0.37	NO
39	IMPDH1	IMPDH1	IMPDH1	10073	-0.039	0.32	NO
40	CDA	CDA	CDA	10342	-0.043	0.31	NO
41	UCK1	UCK1	UCK1	11628	-0.07	0.25	NO
42	TYMP	TYMP	TYMP	11639	-0.07	0.26	NO
43	CES1	CES1	CES1	13275	-0.12	0.18	NO
44	DPYD	DPYD	DPYD	14195	-0.17	0.15	NO
45	UPP2	UPP2	UPP2	14772	-0.2	0.14	NO
46	DPYS	DPYS	DPYS	15830	-0.27	0.11	NO
47	UPB1	UPB1	UPB1	16405	-0.3	0.11	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	UGT1A1	UGT1A1	UGT1A1	78	0.55	0.098	YES
2	UGT1A9	UGT1A9	UGT1A9	145	0.48	0.18	YES
3	UGT1A3	UGT1A3	UGT1A3	246	0.41	0.26	YES
4	UGT1A8	UGT1A8	UGT1A8	367	0.36	0.32	YES
5	UGT2B7	UGT2B7	UGT2B7	412	0.34	0.38	YES
6	UGT1A10	UGT1A10	UGT1A10	450	0.33	0.44	YES
7	UGT1A4	UGT1A4	UGT1A4	470	0.33	0.5	YES
8	UGT2B10	UGT2B10	UGT2B10	624	0.29	0.54	YES
9	UGT1A6	UGT1A6	UGT1A6	751	0.27	0.59	YES
10	XYLB	XYLB	XYLB	807	0.25	0.63	YES
11	UGT2A3	UGT2A3	UGT2A3	867	0.24	0.67	YES
12	UGT2B28	UGT2B28	UGT2B28	1015	0.22	0.71	YES
13	UGT1A7	UGT1A7	UGT1A7	1069	0.21	0.74	YES
14	CRYL1	CRYL1	CRYL1	1181	0.2	0.77	YES
15	UGT2B15	UGT2B15	UGT2B15	1210	0.19	0.81	YES
16	DHDH	DHDH	DHDH	2116	0.12	0.78	NO
17	UGT2B11	UGT2B11	UGT2B11	2269	0.12	0.8	NO
18	UGT2A1	UGT2A1	UGT2A1	2473	0.1	0.8	NO
19	GUSB	GUSB	GUSB	3708	0.065	0.75	NO
20	DCXR	DCXR	DCXR	4791	0.041	0.7	NO
21	RPE	RPE	RPE	6815	0.0092	0.59	NO
22	UGDH	UGDH	UGDH	7569	-0.00097	0.55	NO
23	UGT2B4	UGT2B4	UGT2B4	8130	-0.0082	0.52	NO
24	UGP2	UGP2	UGP2	9611	-0.032	0.45	NO
25	LOC729020	LOC729020	LOC729020	9741	-0.034	0.44	NO
26	AKR1B1	AKR1B1	AKR1B1	13744	-0.15	0.26	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CYP3A7	CYP3A7	CYP3A7	70	0.56	0.037	YES
2	CYP2B6	CYP2B6	CYP2B6	76	0.55	0.078	YES
3	UGT1A1	UGT1A1	UGT1A1	78	0.55	0.12	YES
4	CYP2C9	CYP2C9	CYP2C9	91	0.53	0.16	YES
5	CYP2C19	CYP2C19	CYP2C19	95	0.53	0.19	YES
6	CYP2C18	CYP2C18	CYP2C18	128	0.5	0.23	YES
7	UGT1A9	UGT1A9	UGT1A9	145	0.48	0.26	YES
8	BCMO1	BCMO1	BCMO1	150	0.48	0.3	YES
9	CYP3A5	CYP3A5	CYP3A5	236	0.42	0.32	YES
10	UGT1A3	UGT1A3	UGT1A3	246	0.41	0.35	YES
11	CYP3A4	CYP3A4	CYP3A4	274	0.4	0.38	YES
12	CYP2A7	CYP2A7	CYP2A7	296	0.39	0.41	YES
13	UGT1A8	UGT1A8	UGT1A8	367	0.36	0.43	YES
14	UGT2B7	UGT2B7	UGT2B7	412	0.34	0.45	YES
15	ADH6	ADH6	ADH6	441	0.33	0.48	YES
16	UGT1A10	UGT1A10	UGT1A10	450	0.33	0.5	YES
17	UGT1A4	UGT1A4	UGT1A4	470	0.33	0.52	YES
18	RDH5	RDH5	RDH5	515	0.32	0.54	YES
19	UGT2B10	UGT2B10	UGT2B10	624	0.29	0.56	YES
20	ADH1C	ADH1C	ADH1C	745	0.27	0.57	YES
21	UGT1A6	UGT1A6	UGT1A6	751	0.27	0.59	YES
22	DHRS9	DHRS9	DHRS9	811	0.25	0.6	YES
23	UGT2A3	UGT2A3	UGT2A3	867	0.24	0.62	YES
24	CYP2A6	CYP2A6	CYP2A6	872	0.24	0.64	YES
25	DGAT2	DGAT2	DGAT2	914	0.23	0.65	YES
26	RDH12	RDH12	RDH12	983	0.22	0.66	YES
27	UGT2B28	UGT2B28	UGT2B28	1015	0.22	0.68	YES
28	UGT1A7	UGT1A7	UGT1A7	1069	0.21	0.69	YES
29	UGT2B15	UGT2B15	UGT2B15	1210	0.19	0.7	YES
30	CYP26A1	CYP26A1	CYP26A1	1285	0.19	0.71	YES
31	DGAT1	DGAT1	DGAT1	1310	0.18	0.72	YES
32	RETSAT	RETSAT	RETSAT	1574	0.16	0.72	YES
33	CYP4A11	CYP4A11	CYP4A11	1697	0.15	0.72	YES
34	RDH10	RDH10	RDH10	1928	0.13	0.72	YES
35	RDH16	RDH16	RDH16	2263	0.12	0.71	YES
36	UGT2B11	UGT2B11	UGT2B11	2269	0.12	0.72	YES
37	DHRS3	DHRS3	DHRS3	2391	0.11	0.72	YES
38	UGT2A1	UGT2A1	UGT2A1	2473	0.1	0.72	YES
39	ADH4	ADH4	ADH4	2636	0.098	0.72	NO
40	CYP2C8	CYP2C8	CYP2C8	3908	0.06	0.66	NO
41	ALDH1A1	ALDH1A1	ALDH1A1	4300	0.05	0.64	NO
42	DHRS4L2	DHRS4L2	DHRS4L2	4918	0.038	0.61	NO
43	PNPLA4	PNPLA4	PNPLA4	5954	0.021	0.55	NO
44	CYP26C1	CYP26C1	CYP26C1	6699	0.011	0.51	NO
45	DHRS4	DHRS4	DHRS4	7310	0.0027	0.48	NO
46	RDH11	RDH11	RDH11	7621	-0.0016	0.46	NO
47	UGT2B4	UGT2B4	UGT2B4	8130	-0.0082	0.44	NO
48	ADH5	ADH5	ADH5	9149	-0.024	0.38	NO
49	CYP3A43	CYP3A43	CYP3A43	9192	-0.024	0.38	NO
50	ALDH1A2	ALDH1A2	ALDH1A2	10807	-0.052	0.3	NO
51	CYP1A1	CYP1A1	CYP1A1	12120	-0.084	0.23	NO
52	CYP1A2	CYP1A2	CYP1A2	12282	-0.089	0.23	NO
53	LRAT	LRAT	LRAT	12519	-0.096	0.22	NO
54	RDH8	RDH8	RDH8	12630	-0.1	0.23	NO
55	RPE65	RPE65	RPE65	13797	-0.15	0.17	NO
56	ADH1A	ADH1A	ADH1A	14031	-0.16	0.17	NO
57	AWAT2	AWAT2	AWAT2	14652	-0.19	0.15	NO
58	ADH1B	ADH1B	ADH1B	16672	-0.32	0.067	NO
59	CYP26B1	CYP26B1	CYP26B1	17689	-0.41	0.042	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NDUFA7	NDUFA7	NDUFA7	1899	0.14	-0.06	YES
2	COX5A	COX5A	COX5A	2205	0.12	-0.04	YES
3	COX5B	COX5B	COX5B	2369	0.11	-0.014	YES
4	COX7B	COX7B	COX7B	2730	0.094	-0.0035	YES
5	NDUFV2	NDUFV2	NDUFV2	3168	0.08	-0.002	YES
6	UQCRQ	UQCRQ	UQCRQ	3170	0.08	0.023	YES
7	COX6A1	COX6A1	COX6A1	3207	0.079	0.046	YES
8	NDUFS7	NDUFS7	NDUFS7	3278	0.077	0.067	YES
9	NDUFA4	NDUFA4	NDUFA4	3319	0.076	0.088	YES
10	CYCS	CYCS	CYCS	3354	0.074	0.11	YES
11	NDUFA3	NDUFA3	NDUFA3	3371	0.074	0.13	YES
12	NDUFB3	NDUFB3	NDUFB3	3418	0.072	0.15	YES
13	COX6B1	COX6B1	COX6B1	3420	0.072	0.18	YES
14	ETFB	ETFB	ETFB	3486	0.071	0.2	YES
15	ETFA	ETFA	ETFA	3508	0.07	0.22	YES
16	SDHA	SDHA	SDHA	3537	0.07	0.24	YES
17	NDUFC1	NDUFC1	NDUFC1	3598	0.068	0.26	YES
18	NDUFB7	NDUFB7	NDUFB7	3617	0.067	0.28	YES
19	UQCRHL	UQCRHL	UQCRHL	3669	0.066	0.29	YES
20	NDUFA1	NDUFA1	NDUFA1	3812	0.062	0.31	YES
21	NDUFA2	NDUFA2	NDUFA2	3856	0.061	0.32	YES
22	NDUFS3	NDUFS3	NDUFS3	3871	0.061	0.34	YES
23	COX6C	COX6C	COX6C	3880	0.061	0.36	YES
24	COX4I1	COX4I1	COX4I1	3891	0.06	0.38	YES
25	NDUFS6	NDUFS6	NDUFS6	3894	0.06	0.4	YES
26	UQCR11	UQCR11	UQCR11	3977	0.058	0.41	YES
27	CYC1	CYC1	CYC1	4096	0.055	0.42	YES
28	COX7C	COX7C	COX7C	4120	0.054	0.44	YES
29	NDUFS2	NDUFS2	NDUFS2	4135	0.054	0.46	YES
30	NDUFB10	NDUFB10	NDUFB10	4140	0.054	0.47	YES
31	NDUFA12	NDUFA12	NDUFA12	4144	0.054	0.49	YES
32	UQCRC1	UQCRC1	UQCRC1	4149	0.054	0.51	YES
33	SDHC	SDHC	SDHC	4375	0.049	0.51	YES
34	UQCRH	UQCRH	UQCRH	4384	0.049	0.52	YES
35	NDUFA13	NDUFA13	NDUFA13	4505	0.047	0.53	YES
36	NDUFS5	NDUFS5	NDUFS5	4632	0.044	0.54	YES
37	NDUFB1	NDUFB1	NDUFB1	4705	0.042	0.55	YES
38	COX8A	COX8A	COX8A	4748	0.042	0.56	YES
39	NDUFA10	NDUFA10	NDUFA10	4785	0.041	0.57	YES
40	NDUFAB1	NDUFAB1	NDUFAB1	4799	0.04	0.58	YES
41	ETFDH	ETFDH	ETFDH	4850	0.04	0.59	YES
42	NDUFB8	NDUFB8	NDUFB8	4891	0.039	0.6	YES
43	UQCRC2	UQCRC2	UQCRC2	4931	0.038	0.61	YES
44	NDUFA9	NDUFA9	NDUFA9	5109	0.035	0.62	YES
45	NDUFS8	NDUFS8	NDUFS8	5113	0.035	0.63	YES
46	NDUFA11	NDUFA11	NDUFA11	5127	0.035	0.64	YES
47	NDUFC2	NDUFC2	NDUFC2	5292	0.032	0.64	YES
48	NDUFV3	NDUFV3	NDUFV3	5327	0.031	0.64	YES
49	NDUFB9	NDUFB9	NDUFB9	5504	0.028	0.64	YES
50	NDUFB2	NDUFB2	NDUFB2	5854	0.023	0.63	YES
51	NDUFA8	NDUFA8	NDUFA8	5978	0.021	0.63	YES
52	NDUFB4	NDUFB4	NDUFB4	6072	0.019	0.63	YES
53	NDUFV1	NDUFV1	NDUFV1	6083	0.019	0.64	YES
54	UQCRFS1	UQCRFS1	UQCRFS1	6237	0.017	0.64	YES
55	NDUFA5	NDUFA5	NDUFA5	6290	0.016	0.64	YES
56	NDUFA6	NDUFA6	NDUFA6	6291	0.016	0.64	YES
57	NDUFS4	NDUFS4	NDUFS4	6338	0.016	0.65	YES
58	SDHD	SDHD	SDHD	6521	0.013	0.64	NO
59	NDUFB5	NDUFB5	NDUFB5	6528	0.013	0.64	NO
60	NDUFS1	NDUFS1	NDUFS1	7287	0.0031	0.6	NO
61	COX7A2L	COX7A2L	COX7A2L	7351	0.002	0.6	NO
62	NDUFB6	NDUFB6	NDUFB6	7440	0.00073	0.6	NO
63	SDHB	SDHB	SDHB	7647	-0.002	0.59	NO
64	UQCRB	UQCRB	UQCRB	7728	-0.0031	0.58	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NDUFA7	NDUFA7	NDUFA7	1899	0.14	-0.068	YES
2	COX5A	COX5A	COX5A	2205	0.12	-0.055	YES
3	COX5B	COX5B	COX5B	2369	0.11	-0.035	YES
4	ATP5D	ATP5D	ATP5D	2440	0.11	-0.011	YES
5	COX7B	COX7B	COX7B	2730	0.094	-0.0028	YES
6	ATP5I	ATP5I	ATP5I	3092	0.082	-0.0012	YES
7	NDUFV2	NDUFV2	NDUFV2	3168	0.08	0.015	YES
8	UQCRQ	UQCRQ	UQCRQ	3170	0.08	0.036	YES
9	COX6A1	COX6A1	COX6A1	3207	0.079	0.054	YES
10	NDUFS7	NDUFS7	NDUFS7	3278	0.077	0.07	YES
11	NDUFA4	NDUFA4	NDUFA4	3319	0.076	0.088	YES
12	CYCS	CYCS	CYCS	3354	0.074	0.1	YES
13	NDUFA3	NDUFA3	NDUFA3	3371	0.074	0.12	YES
14	NDUFB3	NDUFB3	NDUFB3	3418	0.072	0.14	YES
15	COX6B1	COX6B1	COX6B1	3420	0.072	0.16	YES
16	ETFB	ETFB	ETFB	3486	0.071	0.17	YES
17	ETFA	ETFA	ETFA	3508	0.07	0.19	YES
18	SDHA	SDHA	SDHA	3537	0.07	0.21	YES
19	NDUFC1	NDUFC1	NDUFC1	3598	0.068	0.22	YES
20	NDUFB7	NDUFB7	NDUFB7	3617	0.067	0.24	YES
21	UQCRHL	UQCRHL	UQCRHL	3669	0.066	0.25	YES
22	NDUFA1	NDUFA1	NDUFA1	3812	0.062	0.26	YES
23	ATP5J2	ATP5J2	ATP5J2	3845	0.062	0.27	YES
24	NDUFA2	NDUFA2	NDUFA2	3856	0.061	0.29	YES
25	NDUFS3	NDUFS3	NDUFS3	3871	0.061	0.3	YES
26	COX6C	COX6C	COX6C	3880	0.061	0.32	YES
27	COX4I1	COX4I1	COX4I1	3891	0.06	0.33	YES
28	NDUFS6	NDUFS6	NDUFS6	3894	0.06	0.35	YES
29	UQCR11	UQCR11	UQCR11	3977	0.058	0.36	YES
30	ATP5G1	ATP5G1	ATP5G1	3990	0.058	0.38	YES
31	ATP5C1	ATP5C1	ATP5C1	4051	0.056	0.39	YES
32	CYC1	CYC1	CYC1	4096	0.055	0.4	YES
33	COX7C	COX7C	COX7C	4120	0.054	0.41	YES
34	NDUFS2	NDUFS2	NDUFS2	4135	0.054	0.42	YES
35	NDUFB10	NDUFB10	NDUFB10	4140	0.054	0.44	YES
36	NDUFA12	NDUFA12	NDUFA12	4144	0.054	0.45	YES
37	UQCRC1	UQCRC1	UQCRC1	4149	0.054	0.46	YES
38	SDHC	SDHC	SDHC	4375	0.049	0.46	YES
39	UQCRH	UQCRH	UQCRH	4384	0.049	0.48	YES
40	ATP5O	ATP5O	ATP5O	4493	0.047	0.48	YES
41	NDUFA13	NDUFA13	NDUFA13	4505	0.047	0.5	YES
42	NDUFS5	NDUFS5	NDUFS5	4632	0.044	0.5	YES
43	NDUFB1	NDUFB1	NDUFB1	4705	0.042	0.51	YES
44	COX8A	COX8A	COX8A	4748	0.042	0.52	YES
45	NDUFA10	NDUFA10	NDUFA10	4785	0.041	0.52	YES
46	NDUFAB1	NDUFAB1	NDUFAB1	4799	0.04	0.53	YES
47	ETFDH	ETFDH	ETFDH	4850	0.04	0.54	YES
48	NDUFB8	NDUFB8	NDUFB8	4891	0.039	0.55	YES
49	UQCRC2	UQCRC2	UQCRC2	4931	0.038	0.56	YES
50	NDUFA9	NDUFA9	NDUFA9	5109	0.035	0.56	YES
51	NDUFS8	NDUFS8	NDUFS8	5113	0.035	0.56	YES
52	NDUFA11	NDUFA11	NDUFA11	5127	0.035	0.57	YES
53	NDUFC2	NDUFC2	NDUFC2	5292	0.032	0.57	YES
54	NDUFV3	NDUFV3	NDUFV3	5327	0.031	0.58	YES
55	NDUFB9	NDUFB9	NDUFB9	5504	0.028	0.58	YES
56	NDUFB2	NDUFB2	NDUFB2	5854	0.023	0.56	YES
57	ATP5B	ATP5B	ATP5B	5903	0.022	0.57	YES
58	NDUFA8	NDUFA8	NDUFA8	5978	0.021	0.57	YES
59	ATP5E	ATP5E	ATP5E	6015	0.02	0.57	YES
60	NDUFB4	NDUFB4	NDUFB4	6072	0.019	0.57	YES
61	NDUFV1	NDUFV1	NDUFV1	6083	0.019	0.58	YES
62	UQCRFS1	UQCRFS1	UQCRFS1	6237	0.017	0.57	YES
63	ATP5L	ATP5L	ATP5L	6287	0.016	0.57	YES
64	NDUFA5	NDUFA5	NDUFA5	6290	0.016	0.58	YES
65	NDUFA6	NDUFA6	NDUFA6	6291	0.016	0.58	YES
66	NDUFS4	NDUFS4	NDUFS4	6338	0.016	0.58	YES
67	ATP5H	ATP5H	ATP5H	6352	0.016	0.59	YES
68	SDHD	SDHD	SDHD	6521	0.013	0.58	NO
69	NDUFB5	NDUFB5	NDUFB5	6528	0.013	0.59	NO
70	ATP5J	ATP5J	ATP5J	6625	0.012	0.58	NO
71	NDUFS1	NDUFS1	NDUFS1	7287	0.0031	0.55	NO
72	COX7A2L	COX7A2L	COX7A2L	7351	0.002	0.55	NO
73	NDUFB6	NDUFB6	NDUFB6	7440	0.00073	0.54	NO
74	SDHB	SDHB	SDHB	7647	-0.002	0.53	NO
75	UQCRB	UQCRB	UQCRB	7728	-0.0031	0.53	NO
76	ATP5F1	ATP5F1	ATP5F1	7993	-0.0065	0.51	NO
77	UCP2	UCP2	UCP2	8479	-0.014	0.49	NO
78	ATP5A1	ATP5A1	ATP5A1	10422	-0.045	0.4	NO
79	UCP3	UCP3	UCP3	13913	-0.15	0.25	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SLC16A8	SLC16A8	SLC16A8	1404	0.18	-0.047	YES
2	SLC16A1	SLC16A1	SLC16A1	1803	0.14	-0.045	YES
3	D2HGDH	D2HGDH	D2HGDH	1859	0.14	-0.025	YES
4	NDUFA7	NDUFA7	NDUFA7	1899	0.14	-0.0047	YES
5	COX5A	COX5A	COX5A	2205	0.12	-0.0017	YES
6	COX5B	COX5B	COX5B	2369	0.11	0.0077	YES
7	SUCLG2	SUCLG2	SUCLG2	2433	0.11	0.022	YES
8	ATP5D	ATP5D	ATP5D	2440	0.11	0.04	YES
9	IDH1	IDH1	IDH1	2689	0.096	0.042	YES
10	COX7B	COX7B	COX7B	2730	0.094	0.056	YES
11	ATP5I	ATP5I	ATP5I	3092	0.082	0.05	YES
12	NDUFV2	NDUFV2	NDUFV2	3168	0.08	0.059	YES
13	UQCRQ	UQCRQ	UQCRQ	3170	0.08	0.072	YES
14	COX6A1	COX6A1	COX6A1	3207	0.079	0.084	YES
15	PDK2	PDK2	PDK2	3246	0.077	0.094	YES
16	NDUFS7	NDUFS7	NDUFS7	3278	0.077	0.11	YES
17	NDUFA4	NDUFA4	NDUFA4	3319	0.076	0.12	YES
18	CYCS	CYCS	CYCS	3354	0.074	0.13	YES
19	NDUFA3	NDUFA3	NDUFA3	3371	0.074	0.14	YES
20	FH	FH	FH	3389	0.073	0.15	YES
21	NDUFB3	NDUFB3	NDUFB3	3418	0.072	0.16	YES
22	COX6B1	COX6B1	COX6B1	3420	0.072	0.17	YES
23	ETFB	ETFB	ETFB	3486	0.071	0.18	YES
24	ETFA	ETFA	ETFA	3508	0.07	0.19	YES
25	SDHA	SDHA	SDHA	3537	0.07	0.2	YES
26	NDUFC1	NDUFC1	NDUFC1	3598	0.068	0.21	YES
27	NDUFB7	NDUFB7	NDUFB7	3617	0.067	0.22	YES
28	UQCRHL	UQCRHL	UQCRHL	3669	0.066	0.23	YES
29	NDUFA1	NDUFA1	NDUFA1	3812	0.062	0.23	YES
30	ATP5J2	ATP5J2	ATP5J2	3845	0.062	0.24	YES
31	NDUFA2	NDUFA2	NDUFA2	3856	0.061	0.25	YES
32	NDUFS3	NDUFS3	NDUFS3	3871	0.061	0.26	YES
33	COX6C	COX6C	COX6C	3880	0.061	0.27	YES
34	COX4I1	COX4I1	COX4I1	3891	0.06	0.28	YES
35	NDUFS6	NDUFS6	NDUFS6	3894	0.06	0.29	YES
36	UQCR11	UQCR11	UQCR11	3977	0.058	0.29	YES
37	ATP5G1	ATP5G1	ATP5G1	3990	0.058	0.3	YES
38	ATP5C1	ATP5C1	ATP5C1	4051	0.056	0.31	YES
39	CYC1	CYC1	CYC1	4096	0.055	0.31	YES
40	COX7C	COX7C	COX7C	4120	0.054	0.32	YES
41	NDUFS2	NDUFS2	NDUFS2	4135	0.054	0.33	YES
42	NDUFB10	NDUFB10	NDUFB10	4140	0.054	0.34	YES
43	NDUFA12	NDUFA12	NDUFA12	4144	0.054	0.35	YES
44	UQCRC1	UQCRC1	UQCRC1	4149	0.054	0.36	YES
45	SDHC	SDHC	SDHC	4375	0.049	0.35	YES
46	UQCRH	UQCRH	UQCRH	4384	0.049	0.36	YES
47	BSG	BSG	BSG	4418	0.048	0.37	YES
48	ATP5O	ATP5O	ATP5O	4493	0.047	0.37	YES
49	NDUFA13	NDUFA13	NDUFA13	4505	0.047	0.38	YES
50	MDH2	MDH2	MDH2	4525	0.046	0.38	YES
51	NDUFS5	NDUFS5	NDUFS5	4632	0.044	0.39	YES
52	NDUFB1	NDUFB1	NDUFB1	4705	0.042	0.39	YES
53	COX8A	COX8A	COX8A	4748	0.042	0.39	YES
54	NDUFA10	NDUFA10	NDUFA10	4785	0.041	0.4	YES
55	NDUFAB1	NDUFAB1	NDUFAB1	4799	0.04	0.4	YES
56	ETFDH	ETFDH	ETFDH	4850	0.04	0.41	YES
57	NDUFB8	NDUFB8	NDUFB8	4891	0.039	0.41	YES
58	UQCRC2	UQCRC2	UQCRC2	4931	0.038	0.42	YES
59	NDUFA9	NDUFA9	NDUFA9	5109	0.035	0.41	YES
60	NDUFS8	NDUFS8	NDUFS8	5113	0.035	0.42	YES
61	NDUFA11	NDUFA11	NDUFA11	5127	0.035	0.42	YES
62	NDUFC2	NDUFC2	NDUFC2	5292	0.032	0.42	YES
63	NDUFV3	NDUFV3	NDUFV3	5327	0.031	0.42	YES
64	SUCLG1	SUCLG1	SUCLG1	5369	0.03	0.43	YES
65	NDUFB9	NDUFB9	NDUFB9	5504	0.028	0.42	YES
66	OGDH	OGDH	OGDH	5597	0.027	0.42	YES
67	LDHA	LDHA	LDHA	5710	0.025	0.42	YES
68	IDH3B	IDH3B	IDH3B	5806	0.024	0.42	YES
69	NDUFB2	NDUFB2	NDUFB2	5854	0.023	0.42	YES
70	ATP5B	ATP5B	ATP5B	5903	0.022	0.42	YES
71	IDH3G	IDH3G	IDH3G	5925	0.022	0.43	YES
72	NDUFA8	NDUFA8	NDUFA8	5978	0.021	0.43	YES
73	ATP5E	ATP5E	ATP5E	6015	0.02	0.43	YES
74	NDUFB4	NDUFB4	NDUFB4	6072	0.019	0.43	YES
75	NDUFV1	NDUFV1	NDUFV1	6083	0.019	0.43	YES
76	PDHA1	PDHA1	PDHA1	6109	0.019	0.43	YES
77	UQCRFS1	UQCRFS1	UQCRFS1	6237	0.017	0.43	YES
78	ATP5L	ATP5L	ATP5L	6287	0.016	0.43	YES
79	NDUFA5	NDUFA5	NDUFA5	6290	0.016	0.43	YES
80	NDUFA6	NDUFA6	NDUFA6	6291	0.016	0.43	YES
81	NDUFS4	NDUFS4	NDUFS4	6338	0.016	0.43	YES
82	ATP5H	ATP5H	ATP5H	6352	0.016	0.44	YES
83	SDHD	SDHD	SDHD	6521	0.013	0.43	NO
84	NDUFB5	NDUFB5	NDUFB5	6528	0.013	0.43	NO
85	ACO2	ACO2	ACO2	6573	0.013	0.43	NO
86	ATP5J	ATP5J	ATP5J	6625	0.012	0.43	NO
87	SLC16A3	SLC16A3	SLC16A3	6653	0.012	0.43	NO
88	PDHX	PDHX	PDHX	6826	0.009	0.42	NO
89	DLST	DLST	DLST	7176	0.0046	0.4	NO
90	PDP2	PDP2	PDP2	7273	0.0034	0.4	NO
91	NDUFS1	NDUFS1	NDUFS1	7287	0.0031	0.4	NO
92	COX7A2L	COX7A2L	COX7A2L	7351	0.002	0.4	NO
93	CS	CS	CS	7379	0.0017	0.4	NO
94	NDUFB6	NDUFB6	NDUFB6	7440	0.00073	0.39	NO
95	SDHB	SDHB	SDHB	7647	-0.002	0.38	NO
96	UQCRB	UQCRB	UQCRB	7728	-0.0031	0.38	NO
97	DLD	DLD	DLD	7794	-0.0039	0.37	NO
98	ATP5F1	ATP5F1	ATP5F1	7993	-0.0065	0.36	NO
99	IDH3A	IDH3A	IDH3A	8205	-0.0093	0.35	NO
100	UCP2	UCP2	UCP2	8479	-0.014	0.34	NO
101	PDP1	PDP1	PDP1	8589	-0.015	0.34	NO
102	PDPR	PDPR	PDPR	9307	-0.026	0.3	NO
103	L2HGDH	L2HGDH	L2HGDH	9521	-0.03	0.3	NO
104	IDH2	IDH2	IDH2	9539	-0.03	0.3	NO
105	DLAT	DLAT	DLAT	9664	-0.032	0.3	NO
106	PDK1	PDK1	PDK1	9698	-0.033	0.3	NO
107	PDHB	PDHB	PDHB	10219	-0.041	0.28	NO
108	ATP5A1	ATP5A1	ATP5A1	10422	-0.045	0.28	NO
109	NNT	NNT	NNT	10538	-0.047	0.28	NO
110	SUCLA2	SUCLA2	SUCLA2	10972	-0.055	0.27	NO
111	PDK3	PDK3	PDK3	12744	-0.1	0.19	NO
112	UCP3	UCP3	UCP3	13913	-0.15	0.15	NO
113	LDHB	LDHB	LDHB	14519	-0.19	0.15	NO
114	ADHFE1	ADHFE1	ADHFE1	14531	-0.19	0.18	NO
115	PDK4	PDK4	PDK4	15059	-0.22	0.18	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SULT1B1	SULT1B1	SULT1B1	16	0.7	0.058	YES
2	UGT1A1	UGT1A1	UGT1A1	78	0.55	0.1	YES
3	SULT1C2	SULT1C2	SULT1C2	122	0.5	0.14	YES
4	UGT1A9	UGT1A9	UGT1A9	145	0.48	0.18	YES
5	NAT2	NAT2	NAT2	156	0.47	0.22	YES
6	UGT1A3	UGT1A3	UGT1A3	246	0.41	0.25	YES
7	SULT1E1	SULT1E1	SULT1E1	308	0.38	0.28	YES
8	UGT1A8	UGT1A8	UGT1A8	367	0.36	0.3	YES
9	UGT2B7	UGT2B7	UGT2B7	412	0.34	0.33	YES
10	UGT1A4	UGT1A4	UGT1A4	470	0.33	0.35	YES
11	UGT2B10	UGT2B10	UGT2B10	624	0.29	0.37	YES
12	GSTA1	GSTA1	GSTA1	639	0.29	0.39	YES
13	SULT2B1	SULT2B1	SULT2B1	732	0.27	0.41	YES
14	UGT1A6	UGT1A6	UGT1A6	751	0.27	0.43	YES
15	ACSM1	ACSM1	ACSM1	774	0.26	0.45	YES
16	SULT1A2	SULT1A2	SULT1A2	809	0.25	0.47	YES
17	UGT2B28	UGT2B28	UGT2B28	1015	0.22	0.48	YES
18	UGT1A7	UGT1A7	UGT1A7	1069	0.21	0.49	YES
19	NAT1	NAT1	NAT1	1080	0.21	0.51	YES
20	OPLAH	OPLAH	OPLAH	1138	0.2	0.52	YES
21	SULT1A3	SULT1A3	SULT1A3	1235	0.19	0.53	YES
22	GSTO2	GSTO2	GSTO2	1358	0.18	0.54	YES
23	MGST2	MGST2	MGST2	1388	0.18	0.56	YES
24	SULT2A1	SULT2A1	SULT2A1	1447	0.17	0.57	YES
25	BPNT1	BPNT1	BPNT1	1495	0.17	0.58	YES
26	MGST3	MGST3	MGST3	1904	0.14	0.57	YES
27	GSTM4	GSTM4	GSTM4	1951	0.13	0.57	YES
28	SLC35D1	SLC35D1	SLC35D1	2167	0.12	0.57	YES
29	UGT2B11	UGT2B11	UGT2B11	2269	0.12	0.58	YES
30	TPMT	TPMT	TPMT	2272	0.11	0.59	YES
31	GSTP1	GSTP1	GSTP1	2357	0.11	0.59	YES
32	UGT2A1	UGT2A1	UGT2A1	2473	0.1	0.59	YES
33	MAT2A	MAT2A	MAT2A	2497	0.1	0.6	YES
34	GSS	GSS	GSS	2775	0.093	0.59	NO
35	SULT1A1	SULT1A1	SULT1A1	2892	0.089	0.6	NO
36	GGCT	GGCT	GGCT	3116	0.081	0.59	NO
37	AHCY	AHCY	AHCY	3256	0.077	0.59	NO
38	MGST1	MGST1	MGST1	3685	0.066	0.57	NO
39	GSTO1	GSTO1	GSTO1	3953	0.058	0.56	NO
40	GGT7	GGT7	GGT7	4210	0.053	0.55	NO
41	COMT	COMT	COMT	4540	0.046	0.54	NO
42	MAT2B	MAT2B	MAT2B	5099	0.035	0.51	NO
43	UGDH	UGDH	UGDH	7569	-0.00097	0.38	NO
44	UGT2B4	UGT2B4	UGT2B4	8130	-0.0082	0.35	NO
45	CNDP2	CNDP2	CNDP2	8278	-0.01	0.34	NO
46	GSTM1	GSTM1	GSTM1	8653	-0.016	0.32	NO
47	GGT1	GGT1	GGT1	9155	-0.024	0.29	NO
48	UGP2	UGP2	UGP2	9611	-0.032	0.27	NO
49	ACSM2B	ACSM2B	ACSM2B	9721	-0.033	0.27	NO
50	GSTA2	GSTA2	GSTA2	9771	-0.034	0.27	NO
51	GCLC	GCLC	GCLC	9860	-0.036	0.27	NO
52	PAPSS1	PAPSS1	PAPSS1	9927	-0.037	0.27	NO
53	MTR	MTR	MTR	11009	-0.056	0.21	NO
54	CYP1A2	CYP1A2	CYP1A2	12282	-0.089	0.15	NO
55	GSTA4	GSTA4	GSTA4	13453	-0.13	0.099	NO
56	GCLM	GCLM	GCLM	13783	-0.15	0.093	NO
57	PAPSS2	PAPSS2	PAPSS2	13796	-0.15	0.1	NO
58	GGT5	GGT5	GGT5	13987	-0.16	0.11	NO
59	NNMT	NNMT	NNMT	14243	-0.17	0.11	NO
60	MAT1A	MAT1A	MAT1A	14252	-0.17	0.12	NO
61	GLYAT	GLYAT	GLYAT	15516	-0.24	0.074	NO
62	GSTM5	GSTM5	GSTM5	16210	-0.29	0.06	NO
63	SULT4A1	SULT4A1	SULT4A1	17178	-0.36	0.038	NO
64	SULT1C4	SULT1C4	SULT1C4	17356	-0.38	0.06	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	UGT1A1	UGT1A1	UGT1A1	78	0.55	0.088	YES
2	UGT1A9	UGT1A9	UGT1A9	145	0.48	0.16	YES
3	UGT1A3	UGT1A3	UGT1A3	246	0.41	0.23	YES
4	UGT1A8	UGT1A8	UGT1A8	367	0.36	0.28	YES
5	UGT2B7	UGT2B7	UGT2B7	412	0.34	0.34	YES
6	UGT1A10	UGT1A10	UGT1A10	450	0.33	0.39	YES
7	UGT1A4	UGT1A4	UGT1A4	470	0.33	0.44	YES
8	UGT2B10	UGT2B10	UGT2B10	624	0.29	0.48	YES
9	UGT1A6	UGT1A6	UGT1A6	751	0.27	0.52	YES
10	UGT2A3	UGT2A3	UGT2A3	867	0.24	0.56	YES
11	UGT2B28	UGT2B28	UGT2B28	1015	0.22	0.59	YES
12	UGT1A7	UGT1A7	UGT1A7	1069	0.21	0.62	YES
13	UGT2B15	UGT2B15	UGT2B15	1210	0.19	0.64	YES
14	UGT2B11	UGT2B11	UGT2B11	2269	0.12	0.6	NO
15	BLVRB	BLVRB	BLVRB	2275	0.11	0.62	NO
16	UGT2A1	UGT2A1	UGT2A1	2473	0.1	0.63	NO
17	ALAS1	ALAS1	ALAS1	2960	0.086	0.62	NO
18	HCCS	HCCS	HCCS	3230	0.078	0.62	NO
19	COX15	COX15	COX15	3535	0.07	0.61	NO
20	GUSB	GUSB	GUSB	3708	0.065	0.61	NO
21	HMBS	HMBS	HMBS	3811	0.062	0.62	NO
22	MMAB	MMAB	MMAB	3958	0.058	0.62	NO
23	HMOX2	HMOX2	HMOX2	4348	0.05	0.61	NO
24	PPOX	PPOX	PPOX	5361	0.03	0.56	NO
25	ALAD	ALAD	ALAD	5415	0.03	0.56	NO
26	EPRS	EPRS	EPRS	6250	0.017	0.52	NO
27	EARS2	EARS2	EARS2	6592	0.012	0.5	NO
28	COX10	COX10	COX10	6690	0.011	0.5	NO
29	CPOX	CPOX	CPOX	7333	0.0024	0.46	NO
30	UROS	UROS	UROS	7925	-0.0054	0.43	NO
31	UGT2B4	UGT2B4	UGT2B4	8130	-0.0082	0.42	NO
32	BLVRA	BLVRA	BLVRA	8349	-0.011	0.41	NO
33	FTH1	FTH1	FTH1	10310	-0.043	0.31	NO
34	UROD	UROD	UROD	11369	-0.064	0.27	NO
35	CP	CP	CP	12122	-0.084	0.24	NO
36	FECH	FECH	FECH	14331	-0.18	0.15	NO
37	HMOX1	HMOX1	HMOX1	14733	-0.2	0.16	NO
38	ALAS2	ALAS2	ALAS2	15480	-0.24	0.16	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	LSM4	LSM4	LSM4	2543	0.1	-0.064	YES
2	C2orf29	C2orf29	C2orf29	2662	0.097	-0.00011	YES
3	EXOSC5	EXOSC5	EXOSC5	3152	0.08	0.032	YES
4	EXOSC1	EXOSC1	EXOSC1	3186	0.079	0.087	YES
5	EXOSC4	EXOSC4	EXOSC4	3661	0.066	0.11	YES
6	LSM5	LSM5	LSM5	4280	0.051	0.11	YES
7	EXOSC7	EXOSC7	EXOSC7	4680	0.043	0.12	YES
8	EXOSC8	EXOSC8	EXOSC8	5142	0.034	0.12	YES
9	PATL1	PATL1	PATL1	5207	0.033	0.14	YES
10	EXOSC3	EXOSC3	EXOSC3	5213	0.033	0.17	YES
11	PABPC1	PABPC1	PABPC1	5533	0.028	0.17	YES
12	DCPS	DCPS	DCPS	5554	0.027	0.19	YES
13	PARN	PARN	PARN	5627	0.026	0.2	YES
14	EDC4	EDC4	EDC4	5890	0.022	0.2	YES
15	EXOSC6	EXOSC6	EXOSC6	5967	0.021	0.22	YES
16	TNKS1BP1	TNKS1BP1	TNKS1BP1	6230	0.017	0.22	YES
17	EXOSC2	EXOSC2	EXOSC2	6403	0.015	0.22	YES
18	LSM2	LSM2	LSM2	6519	0.013	0.22	YES
19	LSM6	LSM6	LSM6	6877	0.0084	0.21	YES
20	CNOT2	CNOT2	CNOT2	6886	0.0083	0.21	YES
21	CNOT6	CNOT6	CNOT6	6915	0.0078	0.22	YES
22	DIS3	DIS3	DIS3	7043	0.0063	0.21	YES
23	LSM1	LSM1	LSM1	7112	0.0056	0.21	YES
24	CNOT3	CNOT3	CNOT3	7180	0.0046	0.21	YES
25	CNOT10	CNOT10	CNOT10	7298	0.003	0.21	YES
26	CNOT8	CNOT8	CNOT8	7358	0.002	0.21	YES
27	LSM3	LSM3	LSM3	8124	-0.0081	0.17	YES
28	PAIP1	PAIP1	PAIP1	8264	-0.01	0.17	YES
29	EIF4A1	EIF4A1	EIF4A1	8566	-0.015	0.17	YES
30	EIF4G1	EIF4G1	EIF4G1	8580	-0.015	0.18	YES
31	EIF4A2	EIF4A2	EIF4A2	8927	-0.021	0.17	YES
32	EXOSC9	EXOSC9	EXOSC9	8955	-0.021	0.19	YES
33	EDC3	EDC3	EDC3	9088	-0.023	0.2	YES
34	EIF4A3	EIF4A3	EIF4A3	9144	-0.024	0.21	YES
35	CNOT4	CNOT4	CNOT4	9159	-0.024	0.23	YES
36	EIF4E	EIF4E	EIF4E	9189	-0.024	0.24	YES
37	EIF4B	EIF4B	EIF4B	9394	-0.028	0.25	YES
38	DCP1A	DCP1A	DCP1A	9921	-0.036	0.25	YES
39	DCP1B	DCP1B	DCP1B	10237	-0.042	0.26	YES
40	DDX6	DDX6	DDX6	10508	-0.046	0.28	YES
41	RQCD1	RQCD1	RQCD1	10550	-0.047	0.31	YES
42	CNOT7	CNOT7	CNOT7	10695	-0.05	0.34	YES
43	DCP2	DCP2	DCP2	10863	-0.053	0.37	YES
44	XRN1	XRN1	XRN1	11038	-0.057	0.4	YES

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus2 enriched pathways

Table 4. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus2. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
KEGG LYSINE DEGRADATION	44	genes.ES.table	0.45	1.9	0	0.84	0.27	0.046	0.0097	0.045	0	0.17
KEGG GLYCOSYLPHOSPHATIDYLINOSITOL GPI ANCHOR BIOSYNTHESIS	25	genes.ES.table	0.49	1.7	0.03	0.36	0.85	0.76	0.42	0.44	0.17	0.085
BIOCARTA BIOPEPTIDES PATHWAY	42	genes.ES.table	0.51	1.7	0.011	0.46	0.74	0.14	0.11	0.13	0.18	0.11
BIOCARTA CHREBP2 PATHWAY	40	genes.ES.table	0.55	1.9	0	0.49	0.3	0.18	0.11	0.16	0	0.1
SIG CD40PATHWAYMAP	33	genes.ES.table	0.49	1.7	0.024	0.38	0.8	0.15	0.089	0.14	0.16	0.091
PID P38 MKK3 6PATHWAY	26	genes.ES.table	0.45	1.7	0.015	0.41	0.79	0.15	0.14	0.13	0.17	0.097
PID LKB1 PATHWAY	47	genes.ES.table	0.38	1.7	0.033	0.45	0.77	0.11	0.056	0.1	0.18	0.11
PID LIS1PATHWAY	28	genes.ES.table	0.61	1.8	0.0042	0.41	0.54	0.25	0.11	0.22	0.1	0.097
PID HEDGEHOG GLIPATHWAY	48	genes.ES.table	0.43	1.6	0.024	0.38	0.9	0.15	0.11	0.13	0.2	0.087
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING	59	genes.ES.table	0.33	1.7	0.023	0.42	0.77	0.034	0.013	0.034	0.17	0.098

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	OGDHL	OGDHL	OGDHL	101	0.96	0.24	YES
2	PIPOX	PIPOX	PIPOX	179	0.85	0.45	YES
3	AADAT	AADAT	AADAT	2443	0.21	0.38	NO
4	ACAT1	ACAT1	ACAT1	3430	0.14	0.36	NO
5	HADH	HADH	HADH	3857	0.12	0.37	NO
6	SUV420H2	SUV420H2	SUV420H2	4021	0.11	0.39	NO
7	GCDH	GCDH	GCDH	5023	0.08	0.35	NO
8	AASDH	AASDH	AASDH	5360	0.071	0.35	NO
9	SUV39H1	SUV39H1	SUV39H1	5792	0.061	0.34	NO
10	SETMAR	SETMAR	SETMAR	6038	0.056	0.34	NO
11	ALDH9A1	ALDH9A1	ALDH9A1	6143	0.054	0.35	NO
12	SETDB2	SETDB2	SETDB2	7149	0.034	0.31	NO
13	AASDHPPT	AASDHPPT	AASDHPPT	7155	0.034	0.32	NO
14	DOT1L	DOT1L	DOT1L	7193	0.033	0.32	NO
15	ECHS1	ECHS1	ECHS1	7747	0.024	0.3	NO
16	NSD1	NSD1	NSD1	7801	0.023	0.3	NO
17	SETD1B	SETD1B	SETD1B	8109	0.018	0.29	NO
18	BBOX1	BBOX1	BBOX1	8393	0.014	0.28	NO
19	EHMT2	EHMT2	EHMT2	8910	0.0059	0.25	NO
20	PLOD3	PLOD3	PLOD3	8914	0.0057	0.25	NO
21	SETD1A	SETD1A	SETD1A	9193	0.0014	0.24	NO
22	OGDH	OGDH	OGDH	9314	-0.00048	0.23	NO
23	ALDH3A2	ALDH3A2	ALDH3A2	9355	-0.00097	0.23	NO
24	HADHA	HADHA	HADHA	9453	-0.0023	0.22	NO
25	EHHADH	EHHADH	EHHADH	9992	-0.011	0.2	NO
26	EHMT1	EHMT1	EHMT1	10429	-0.018	0.18	NO
27	SETD2	SETD2	SETD2	10541	-0.02	0.18	NO
28	AASS	AASS	AASS	10607	-0.021	0.18	NO
29	ASH1L	ASH1L	ASH1L	10659	-0.022	0.18	NO
30	WHSC1	WHSC1	WHSC1	11051	-0.028	0.17	NO
31	SETDB1	SETDB1	SETDB1	11060	-0.028	0.17	NO
32	SUV420H1	SUV420H1	SUV420H1	11146	-0.03	0.18	NO
33	DLST	DLST	DLST	11189	-0.031	0.18	NO
34	ACAT2	ACAT2	ACAT2	11659	-0.039	0.17	NO
35	SUV39H2	SUV39H2	SUV39H2	11981	-0.044	0.16	NO
36	TMLHE	TMLHE	TMLHE	12286	-0.051	0.16	NO
37	SETD7	SETD7	SETD7	12505	-0.055	0.16	NO
38	WHSC1L1	WHSC1L1	WHSC1L1	12770	-0.061	0.16	NO
39	SETD8	SETD8	SETD8	13264	-0.072	0.15	NO
40	PLOD1	PLOD1	PLOD1	13787	-0.086	0.14	NO
41	ALDH7A1	ALDH7A1	ALDH7A1	13791	-0.086	0.17	NO
42	ALDH2	ALDH2	ALDH2	13964	-0.092	0.18	NO
43	PLOD2	PLOD2	PLOD2	14884	-0.12	0.16	NO
44	ALDH1B1	ALDH1B1	ALDH1B1	15009	-0.13	0.19	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	GCK	GCK	GCK	73	1	0.2	YES
2	PPP2R2B	PPP2R2B	PPP2R2B	491	0.61	0.3	YES
3	MLXIPL	MLXIPL	MLXIPL	636	0.55	0.4	YES
4	PPP2R2C	PPP2R2C	PPP2R2C	1337	0.35	0.43	YES
5	PRKAR2B	PRKAR2B	PRKAR2B	1779	0.28	0.46	YES
6	PPP2R3B	PPP2R3B	PPP2R3B	2025	0.25	0.5	YES
7	PKLR	PKLR	PKLR	2033	0.25	0.55	YES
8	PRKAR1B	PRKAR1B	PRKAR1B	2731	0.19	0.55	NO
9	PPP2R5B	PPP2R5B	PPP2R5B	4189	0.11	0.49	NO
10	PRKACA	PRKACA	PRKACA	4439	0.098	0.5	NO
11	PRKAR1A	PRKAR1A	PRKAR1A	4780	0.087	0.5	NO
12	PRKACB	PRKACB	PRKACB	5572	0.066	0.46	NO
13	YWHAE	YWHAE	YWHAE	5835	0.06	0.46	NO
14	ACACA	ACACA	ACACA	5904	0.059	0.47	NO
15	PPP2R4	PPP2R4	PPP2R4	6604	0.045	0.44	NO
16	PPP2R1A	PPP2R1A	PPP2R1A	6624	0.044	0.45	NO
17	PRKAA2	PRKAA2	PRKAA2	6668	0.044	0.46	NO
18	PRKAG1	PRKAG1	PRKAG1	6859	0.04	0.45	NO
19	PRKAG2	PRKAG2	PRKAG2	7011	0.037	0.45	NO
20	FASN	FASN	FASN	7096	0.035	0.46	NO
21	YWHAQ	YWHAQ	YWHAQ	7103	0.035	0.46	NO
22	PPP2R1B	PPP2R1B	PPP2R1B	7342	0.031	0.46	NO
23	PPP2CB	PPP2CB	PPP2CB	8923	0.0056	0.37	NO
24	YWHAG	YWHAG	YWHAG	9307	-0.0004	0.35	NO
25	YWHAH	YWHAH	YWHAH	9428	-0.0018	0.34	NO
26	PPP2CA	PPP2CA	PPP2CA	9469	-0.0026	0.34	NO
27	PPP2R5D	PPP2R5D	PPP2R5D	9951	-0.01	0.32	NO
28	PPP2R5C	PPP2R5C	PPP2R5C	10091	-0.012	0.31	NO
29	MLX	MLX	MLX	10226	-0.014	0.31	NO
30	PPP2R2D	PPP2R2D	PPP2R2D	10708	-0.022	0.29	NO
31	PRKAB1	PRKAB1	PRKAB1	10795	-0.024	0.29	NO
32	YWHAB	YWHAB	YWHAB	11239	-0.032	0.27	NO
33	PPP2R5A	PPP2R5A	PPP2R5A	11528	-0.037	0.26	NO
34	PRKAB2	PRKAB2	PRKAB2	11955	-0.044	0.25	NO
35	PPP2R5E	PPP2R5E	PPP2R5E	12809	-0.062	0.21	NO
36	PRKAR2A	PRKAR2A	PRKAR2A	13258	-0.072	0.2	NO
37	PRKAA1	PRKAA1	PRKAA1	13550	-0.08	0.2	NO
38	PPP2R2A	PPP2R2A	PPP2R2A	13729	-0.084	0.21	NO
39	YWHAZ	YWHAZ	YWHAZ	14377	-0.1	0.2	NO
40	PPP2R3A	PPP2R3A	PPP2R3A	15136	-0.13	0.18	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	GRIA2	GRIA2	GRIA2	17	1.2	0.18	YES
2	CAMK2B	CAMK2B	CAMK2B	19	1.2	0.35	YES
3	GRIA3	GRIA3	GRIA3	62	1	0.51	YES
4	CACNG2	CACNG2	CACNG2	413	0.66	0.59	YES
5	GRIA4	GRIA4	GRIA4	1088	0.4	0.62	YES
6	CACNG4	CACNG4	CACNG4	1146	0.38	0.67	YES
7	PRKCG	PRKCG	PRKCG	1259	0.36	0.72	YES
8	GRIA1	GRIA1	GRIA1	1644	0.3	0.75	YES
9	NSF	NSF	NSF	4298	0.1	0.62	NO
10	PICK1	PICK1	PICK1	4814	0.086	0.6	NO
11	CACNG8	CACNG8	CACNG8	5084	0.078	0.6	NO
12	CACNG3	CACNG3	CACNG3	5971	0.058	0.56	NO
13	AP2A2	AP2A2	AP2A2	7329	0.031	0.49	NO
14	AP2B1	AP2B1	AP2B1	8510	0.012	0.43	NO
15	AP2S1	AP2S1	AP2S1	8906	0.006	0.41	NO
16	CAMK2D	CAMK2D	CAMK2D	9257	0.00034	0.39	NO
17	AP2M1	AP2M1	AP2M1	10023	-0.011	0.35	NO
18	AP2A1	AP2A1	AP2A1	10106	-0.012	0.35	NO
19	MDM2	MDM2	MDM2	10122	-0.012	0.35	NO
20	GRIP2	GRIP2	GRIP2	10543	-0.02	0.33	NO
21	DLG1	DLG1	DLG1	12149	-0.048	0.25	NO
22	EPB41L1	EPB41L1	EPB41L1	12363	-0.053	0.25	NO
23	MYO6	MYO6	MYO6	12562	-0.056	0.25	NO
24	PRKCA	PRKCA	PRKCA	13493	-0.078	0.21	NO
25	CAMK2A	CAMK2A	CAMK2A	13497	-0.078	0.22	NO
26	PRKCB	PRKCB	PRKCB	13923	-0.091	0.21	NO
27	AKAP5	AKAP5	AKAP5	16902	-0.23	0.084	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CACNA1A	CACNA1A	CACNA1A	27	1.1	0.039	YES
2	SYT5	SYT5	SYT5	52	1.1	0.077	YES
3	SNAP25	SNAP25	SNAP25	97	0.97	0.11	YES
4	ABCC8	ABCC8	ABCC8	122	0.92	0.14	YES
5	KCNJ11	KCNJ11	KCNJ11	136	0.91	0.18	YES
6	PAX6	PAX6	PAX6	157	0.88	0.21	YES
7	ISL1	ISL1	ISL1	180	0.85	0.24	YES
8	GNG4	GNG4	GNG4	188	0.84	0.27	YES
9	PCSK1	PCSK1	PCSK1	189	0.84	0.3	YES
10	GPR119	GPR119	GPR119	191	0.83	0.33	YES
11	ADCY1	ADCY1	ADCY1	295	0.74	0.35	YES
12	FFAR1	FFAR1	FFAR1	306	0.73	0.38	YES
13	CACNB2	CACNB2	CACNB2	321	0.71	0.4	YES
14	GNAO1	GNAO1	GNAO1	352	0.69	0.42	YES
15	KCNC2	KCNC2	KCNC2	368	0.68	0.45	YES
16	KCNB1	KCNB1	KCNB1	451	0.63	0.47	YES
17	GCGR	GCGR	GCGR	536	0.59	0.48	YES
18	MLXIPL	MLXIPL	MLXIPL	636	0.55	0.5	YES
19	GNB3	GNB3	GNB3	654	0.53	0.52	YES
20	RAPGEF4	RAPGEF4	RAPGEF4	801	0.48	0.53	YES
21	ADCY2	ADCY2	ADCY2	956	0.43	0.54	YES
22	GNG2	GNG2	GNG2	986	0.43	0.55	YES
23	GNG7	GNG7	GNG7	1124	0.39	0.56	YES
24	GLP1R	GLP1R	GLP1R	1265	0.36	0.56	YES
25	STXBP1	STXBP1	STXBP1	1400	0.34	0.57	YES
26	SEC11C	SEC11C	SEC11C	1464	0.32	0.58	YES
27	STX1A	STX1A	STX1A	1666	0.3	0.58	YES
28	PRKAR2B	PRKAR2B	PRKAR2B	1779	0.28	0.58	YES
29	VAMP2	VAMP2	VAMP2	1921	0.26	0.58	YES
30	ACACB	ACACB	ACACB	1935	0.26	0.59	YES
31	GNAI1	GNAI1	GNAI1	1995	0.26	0.6	YES
32	PKLR	PKLR	PKLR	2033	0.25	0.6	YES
33	GCG	GCG	GCG	2049	0.25	0.61	YES
34	GNAS	GNAS	GNAS	2253	0.23	0.61	YES
35	GNG3	GNG3	GNG3	2256	0.23	0.62	YES
36	PFKFB1	PFKFB1	PFKFB1	2263	0.23	0.63	YES
37	INS	INS	INS	2335	0.22	0.63	YES
38	SLC25A4	SLC25A4	SLC25A4	2472	0.21	0.63	YES
39	ADCY8	ADCY8	ADCY8	2592	0.2	0.63	YES
40	PRKAR1B	PRKAR1B	PRKAR1B	2731	0.19	0.63	NO
41	DPP4	DPP4	DPP4	3762	0.12	0.58	NO
42	ACLY	ACLY	ACLY	3893	0.12	0.58	NO
43	PRKACA	PRKACA	PRKACA	4439	0.098	0.55	NO
44	KCNG2	KCNG2	KCNG2	4536	0.095	0.55	NO
45	GNB5	GNB5	GNB5	4540	0.095	0.55	NO
46	SLC2A2	SLC2A2	SLC2A2	4581	0.094	0.55	NO
47	LEP	LEP	LEP	4751	0.088	0.55	NO
48	PRKAR1A	PRKAR1A	PRKAR1A	4780	0.087	0.55	NO
49	ADCY4	ADCY4	ADCY4	5042	0.08	0.54	NO
50	GNG10	GNG10	GNG10	5122	0.078	0.54	NO
51	PLCB1	PLCB1	PLCB1	5349	0.072	0.53	NO
52	PRKACB	PRKACB	PRKACB	5572	0.066	0.52	NO
53	GNG11	GNG11	GNG11	5673	0.064	0.51	NO
54	STK11	STK11	STK11	5752	0.062	0.51	NO
55	ACACA	ACACA	ACACA	5904	0.059	0.51	NO
56	PPP2R1A	PPP2R1A	PPP2R1A	6624	0.044	0.47	NO
57	PRKAA2	PRKAA2	PRKAA2	6668	0.044	0.47	NO
58	GRP	GRP	GRP	6685	0.043	0.47	NO
59	GNA11	GNA11	GNA11	6709	0.043	0.47	NO
60	GNB2	GNB2	GNB2	6739	0.042	0.47	NO
61	ADCY6	ADCY6	ADCY6	6762	0.042	0.47	NO
62	PRKAG2	PRKAG2	PRKAG2	7011	0.037	0.46	NO
63	AGPAT1	AGPAT1	AGPAT1	7083	0.036	0.45	NO
64	FASN	FASN	FASN	7096	0.035	0.46	NO
65	PPP2R1B	PPP2R1B	PPP2R1B	7342	0.031	0.44	NO
66	SPCS1	SPCS1	SPCS1	7970	0.02	0.41	NO
67	ADCY3	ADCY3	ADCY3	8084	0.018	0.4	NO
68	GNAI2	GNAI2	GNAI2	8375	0.014	0.39	NO
69	MARCKS	MARCKS	MARCKS	8646	0.0096	0.37	NO
70	SPCS2	SPCS2	SPCS2	8857	0.0065	0.36	NO
71	PPP2CB	PPP2CB	PPP2CB	8923	0.0056	0.36	NO
72	SLC25A6	SLC25A6	SLC25A6	8971	0.0047	0.36	NO
73	LOC653566	LOC653566	LOC653566	8979	0.0046	0.36	NO
74	ADCY9	ADCY9	ADCY9	9024	0.0039	0.36	NO
75	GNA14	GNA14	GNA14	9367	-0.0011	0.34	NO
76	PPP2CA	PPP2CA	PPP2CA	9469	-0.0026	0.33	NO
77	GNAQ	GNAQ	GNAQ	9679	-0.0058	0.32	NO
78	GNB1	GNB1	GNB1	9761	-0.0071	0.32	NO
79	PPP2R5D	PPP2R5D	PPP2R5D	9951	-0.01	0.3	NO
80	MLX	MLX	MLX	10226	-0.014	0.29	NO
81	ADCY5	ADCY5	ADCY5	10580	-0.02	0.27	NO
82	SLC25A5	SLC25A5	SLC25A5	10602	-0.021	0.27	NO
83	GNG13	GNG13	GNG13	10804	-0.024	0.26	NO
84	SEC11A	SEC11A	SEC11A	10936	-0.026	0.26	NO
85	GNGT2	GNGT2	GNGT2	11817	-0.042	0.21	NO
86	CACNB3	CACNB3	CACNB3	11871	-0.043	0.21	NO
87	PRKAB2	PRKAB2	PRKAB2	11955	-0.044	0.2	NO
88	SPCS3	SPCS3	SPCS3	12103	-0.047	0.2	NO
89	KCNS3	KCNS3	KCNS3	12640	-0.058	0.17	NO
90	TALDO1	TALDO1	TALDO1	12752	-0.06	0.17	NO
91	RAP1B	RAP1B	RAP1B	12791	-0.061	0.17	NO
92	RAPGEF3	RAPGEF3	RAPGEF3	13109	-0.068	0.15	NO
93	PRKAR2A	PRKAR2A	PRKAR2A	13258	-0.072	0.15	NO
94	GNG8	GNG8	GNG8	13314	-0.073	0.15	NO
95	PRKCA	PRKCA	PRKCA	13493	-0.078	0.14	NO
96	GIP	GIP	GIP	13529	-0.079	0.14	NO
97	CTNNB1	CTNNB1	CTNNB1	13669	-0.083	0.14	NO
98	GNG5	GNG5	GNG5	13821	-0.087	0.13	NO
99	ADCY7	ADCY7	ADCY7	14137	-0.097	0.12	NO
100	RAP1A	RAP1A	RAP1A	14348	-0.1	0.11	NO
101	GNGT1	GNGT1	GNGT1	14480	-0.11	0.11	NO
102	GNB4	GNB4	GNB4	14597	-0.11	0.11	NO
103	GNG12	GNG12	GNG12	14695	-0.12	0.1	NO
104	TKT	TKT	TKT	14791	-0.12	0.1	NO
105	CDX2	CDX2	CDX2	14837	-0.12	0.11	NO
106	ITPR2	ITPR2	ITPR2	14944	-0.12	0.1	NO
107	IQGAP1	IQGAP1	IQGAP1	15360	-0.14	0.087	NO
108	PLCB2	PLCB2	PLCB2	15634	-0.15	0.078	NO
109	ADRA2A	ADRA2A	ADRA2A	15806	-0.16	0.075	NO
110	CHRM3	CHRM3	CHRM3	15883	-0.16	0.077	NO
111	SLC2A1	SLC2A1	SLC2A1	16445	-0.2	0.053	NO
112	PLCB3	PLCB3	PLCB3	16825	-0.23	0.041	NO
113	AKAP5	AKAP5	AKAP5	16902	-0.23	0.045	NO
114	ITPR3	ITPR3	ITPR3	17475	-0.28	0.024	NO
115	GNA15	GNA15	GNA15	18012	-0.35	0.0079	NO
116	GATA4	GATA4	GATA4	18374	-0.44	0.0045	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CDK5R2	CDK5R2	CDK5R2	11	1.2	0.24	YES
2	DCX	DCX	DCX	225	0.8	0.38	YES
3	CDK5R1	CDK5R1	CDK5R1	870	0.46	0.44	YES
4	RELN	RELN	RELN	1336	0.35	0.48	YES
5	MAP1B	MAP1B	MAP1B	1707	0.29	0.52	YES
6	DAB1	DAB1	DAB1	1780	0.28	0.57	YES
7	VLDLR	VLDLR	VLDLR	1986	0.26	0.61	YES
8	LRPAP1	LRPAP1	LRPAP1	3336	0.14	0.57	NO
9	CDK5	CDK5	CDK5	4604	0.093	0.52	NO
10	PAFAH1B1	PAFAH1B1	PAFAH1B1	4871	0.085	0.52	NO
11	YWHAE	YWHAE	YWHAE	5835	0.06	0.48	NO
12	PAFAH1B3	PAFAH1B3	PAFAH1B3	6079	0.055	0.48	NO
13	NDEL1	NDEL1	NDEL1	7916	0.021	0.38	NO
14	NUDC	NUDC	NUDC	9001	0.0042	0.32	NO
15	DYNC1H1	DYNC1H1	DYNC1H1	9142	0.002	0.32	NO
16	DYNLT1	DYNLT1	DYNLT1	9299	-0.00021	0.31	NO
17	ABL1	ABL1	ABL1	9316	-0.00051	0.31	NO
18	PPP2R5D	PPP2R5D	PPP2R5D	9951	-0.01	0.28	NO
19	CLIP1	CLIP1	CLIP1	10749	-0.023	0.24	NO
20	KATNA1	KATNA1	KATNA1	11331	-0.033	0.21	NO
21	RAC1	RAC1	RAC1	11759	-0.041	0.2	NO
22	CDC42	CDC42	CDC42	11766	-0.041	0.21	NO
23	CSNK2A1	CSNK2A1	CSNK2A1	12131	-0.048	0.2	NO
24	RHOA	RHOA	RHOA	12312	-0.052	0.2	NO
25	PAFAH1B2	PAFAH1B2	PAFAH1B2	14561	-0.11	0.096	NO
26	IQGAP1	IQGAP1	IQGAP1	15360	-0.14	0.081	NO
27	LRP8	LRP8	LRP8	16439	-0.2	0.062	NO
28	PLA2G7	PLA2G7	PLA2G7	17046	-0.24	0.077	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SH3GL2	SH3GL2	SH3GL2	45	1.1	0.21	YES
2	DNAJC6	DNAJC6	DNAJC6	245	0.77	0.36	YES
3	VAMP2	VAMP2	VAMP2	1921	0.26	0.32	NO
4	OCRL	OCRL	OCRL	2734	0.19	0.31	NO
5	NECAP1	NECAP1	NECAP1	3536	0.14	0.3	NO
6	TPD52	TPD52	TPD52	3826	0.12	0.31	NO
7	AP1S2	AP1S2	AP1S2	4012	0.11	0.32	NO
8	NAPA	NAPA	NAPA	4328	0.1	0.32	NO
9	BLOC1S1	BLOC1S1	BLOC1S1	4367	0.1	0.34	NO
10	HIP1R	HIP1R	HIP1R	4734	0.089	0.34	NO
11	DTNBP1	DTNBP1	DTNBP1	5208	0.075	0.33	NO
12	AP1S1	AP1S1	AP1S1	6094	0.055	0.29	NO
13	AP1M1	AP1M1	AP1M1	6321	0.05	0.29	NO
14	PLDN	PLDN	PLDN	6695	0.043	0.28	NO
15	SORT1	SORT1	SORT1	6748	0.042	0.28	NO
16	AP3B1	AP3B1	AP3B1	7123	0.035	0.27	NO
17	AP1B1	AP1B1	AP1B1	7374	0.03	0.26	NO
18	CLTA	CLTA	CLTA	7460	0.029	0.26	NO
19	HSPA8	HSPA8	HSPA8	8218	0.016	0.23	NO
20	AP1M2	AP1M2	AP1M2	8438	0.013	0.22	NO
21	CLTC	CLTC	CLTC	8662	0.0093	0.21	NO
22	SNX2	SNX2	SNX2	8766	0.008	0.2	NO
23	TGOLN2	TGOLN2	TGOLN2	9572	-0.0042	0.16	NO
24	ARF1	ARF1	ARF1	9741	-0.0068	0.15	NO
25	BLOC1S3	BLOC1S3	BLOC1S3	9955	-0.01	0.14	NO
26	RAB5C	RAB5C	RAB5C	10012	-0.011	0.14	NO
27	CPD	CPD	CPD	10053	-0.012	0.14	NO
28	GAK	GAK	GAK	10366	-0.017	0.13	NO
29	AP1G1	AP1G1	AP1G1	10631	-0.021	0.12	NO
30	VAMP7	VAMP7	VAMP7	10665	-0.022	0.12	NO
31	IGF2R	IGF2R	IGF2R	10679	-0.022	0.12	NO
32	SNAPIN	SNAPIN	SNAPIN	10957	-0.027	0.12	NO
33	FTL	FTL	FTL	11227	-0.031	0.11	NO
34	PUM1	PUM1	PUM1	11344	-0.033	0.11	NO
35	YIPF6	YIPF6	YIPF6	11735	-0.04	0.094	NO
36	FTH1	FTH1	FTH1	11754	-0.041	0.1	NO
37	ARRB1	ARRB1	ARRB1	11866	-0.043	0.1	NO
38	AP4E1	AP4E1	AP4E1	12087	-0.047	0.1	NO
39	TPD52L1	TPD52L1	TPD52L1	12403	-0.053	0.094	NO
40	TXNDC5	TXNDC5	TXNDC5	12793	-0.061	0.086	NO
41	PICALM	PICALM	PICALM	12920	-0.064	0.092	NO
42	SNX5	SNX5	SNX5	13032	-0.066	0.099	NO
43	TBC1D8B	TBC1D8B	TBC1D8B	13111	-0.068	0.11	NO
44	SNX9	SNX9	SNX9	13112	-0.068	0.12	NO
45	DNM2	DNM2	DNM2	13160	-0.07	0.13	NO
46	PIK3C2A	PIK3C2A	PIK3C2A	13202	-0.071	0.15	NO
47	AP4B1	AP4B1	AP4B1	13471	-0.078	0.15	NO
48	CNO	CNO	CNO	13658	-0.083	0.15	NO
49	AP3S1	AP3S1	AP3S1	14002	-0.093	0.15	NO
50	SH3D19	SH3D19	SH3D19	15350	-0.14	0.11	NO
51	TFRC	TFRC	TFRC	15466	-0.15	0.13	NO
52	VAMP8	VAMP8	VAMP8	15544	-0.15	0.16	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CACNA1A	CACNA1A	CACNA1A	27	1.1	0.046	YES
2	SYT5	SYT5	SYT5	52	1.1	0.09	YES
3	SNAP25	SNAP25	SNAP25	97	0.97	0.13	YES
4	ABCC8	ABCC8	ABCC8	122	0.92	0.17	YES
5	KCNJ11	KCNJ11	KCNJ11	136	0.91	0.21	YES
6	PAX6	PAX6	PAX6	157	0.88	0.24	YES
7	ISL1	ISL1	ISL1	180	0.85	0.28	YES
8	GNG4	GNG4	GNG4	188	0.84	0.31	YES
9	PCSK1	PCSK1	PCSK1	189	0.84	0.35	YES
10	GPR119	GPR119	GPR119	191	0.83	0.39	YES
11	FFAR1	FFAR1	FFAR1	306	0.73	0.41	YES
12	CACNB2	CACNB2	CACNB2	321	0.71	0.44	YES
13	GNAO1	GNAO1	GNAO1	352	0.69	0.47	YES
14	KCNC2	KCNC2	KCNC2	368	0.68	0.5	YES
15	KCNB1	KCNB1	KCNB1	451	0.63	0.52	YES
16	GNB3	GNB3	GNB3	654	0.53	0.53	YES
17	RAPGEF4	RAPGEF4	RAPGEF4	801	0.48	0.55	YES
18	GNG2	GNG2	GNG2	986	0.43	0.55	YES
19	GNG7	GNG7	GNG7	1124	0.39	0.56	YES
20	GLP1R	GLP1R	GLP1R	1265	0.36	0.57	YES
21	STXBP1	STXBP1	STXBP1	1400	0.34	0.58	YES
22	SEC11C	SEC11C	SEC11C	1464	0.32	0.59	YES
23	STX1A	STX1A	STX1A	1666	0.3	0.59	YES
24	PRKAR2B	PRKAR2B	PRKAR2B	1779	0.28	0.6	YES
25	VAMP2	VAMP2	VAMP2	1921	0.26	0.6	YES
26	GNAI1	GNAI1	GNAI1	1995	0.26	0.61	YES
27	GCG	GCG	GCG	2049	0.25	0.62	YES
28	GNAS	GNAS	GNAS	2253	0.23	0.61	YES
29	GNG3	GNG3	GNG3	2256	0.23	0.62	YES
30	INS	INS	INS	2335	0.22	0.63	YES
31	SLC25A4	SLC25A4	SLC25A4	2472	0.21	0.63	YES
32	ADCY8	ADCY8	ADCY8	2592	0.2	0.63	YES
33	PRKAR1B	PRKAR1B	PRKAR1B	2731	0.19	0.63	YES
34	DPP4	DPP4	DPP4	3762	0.12	0.58	NO
35	PRKACA	PRKACA	PRKACA	4439	0.098	0.55	NO
36	KCNG2	KCNG2	KCNG2	4536	0.095	0.55	NO
37	GNB5	GNB5	GNB5	4540	0.095	0.55	NO
38	SLC2A2	SLC2A2	SLC2A2	4581	0.094	0.55	NO
39	LEP	LEP	LEP	4751	0.088	0.55	NO
40	PRKAR1A	PRKAR1A	PRKAR1A	4780	0.087	0.55	NO
41	GNG10	GNG10	GNG10	5122	0.078	0.54	NO
42	PLCB1	PLCB1	PLCB1	5349	0.072	0.53	NO
43	PRKACB	PRKACB	PRKACB	5572	0.066	0.52	NO
44	GNG11	GNG11	GNG11	5673	0.064	0.51	NO
45	GRP	GRP	GRP	6685	0.043	0.46	NO
46	GNA11	GNA11	GNA11	6709	0.043	0.46	NO
47	GNB2	GNB2	GNB2	6739	0.042	0.46	NO
48	ADCY6	ADCY6	ADCY6	6762	0.042	0.46	NO
49	SPCS1	SPCS1	SPCS1	7970	0.02	0.4	NO
50	GNAI2	GNAI2	GNAI2	8375	0.014	0.38	NO
51	MARCKS	MARCKS	MARCKS	8646	0.0096	0.36	NO
52	SPCS2	SPCS2	SPCS2	8857	0.0065	0.35	NO
53	SLC25A6	SLC25A6	SLC25A6	8971	0.0047	0.34	NO
54	LOC653566	LOC653566	LOC653566	8979	0.0046	0.34	NO
55	GNA14	GNA14	GNA14	9367	-0.0011	0.32	NO
56	GNAQ	GNAQ	GNAQ	9679	-0.0058	0.31	NO
57	GNB1	GNB1	GNB1	9761	-0.0071	0.3	NO
58	ADCY5	ADCY5	ADCY5	10580	-0.02	0.26	NO
59	SLC25A5	SLC25A5	SLC25A5	10602	-0.021	0.26	NO
60	GNG13	GNG13	GNG13	10804	-0.024	0.25	NO
61	SEC11A	SEC11A	SEC11A	10936	-0.026	0.24	NO
62	GNGT2	GNGT2	GNGT2	11817	-0.042	0.2	NO
63	CACNB3	CACNB3	CACNB3	11871	-0.043	0.2	NO
64	SPCS3	SPCS3	SPCS3	12103	-0.047	0.18	NO
65	KCNS3	KCNS3	KCNS3	12640	-0.058	0.16	NO
66	RAP1B	RAP1B	RAP1B	12791	-0.061	0.15	NO
67	RAPGEF3	RAPGEF3	RAPGEF3	13109	-0.068	0.14	NO
68	PRKAR2A	PRKAR2A	PRKAR2A	13258	-0.072	0.13	NO
69	GNG8	GNG8	GNG8	13314	-0.073	0.13	NO
70	PRKCA	PRKCA	PRKCA	13493	-0.078	0.13	NO
71	GIP	GIP	GIP	13529	-0.079	0.13	NO
72	CTNNB1	CTNNB1	CTNNB1	13669	-0.083	0.12	NO
73	GNG5	GNG5	GNG5	13821	-0.087	0.12	NO
74	RAP1A	RAP1A	RAP1A	14348	-0.1	0.097	NO
75	GNGT1	GNGT1	GNGT1	14480	-0.11	0.094	NO
76	GNB4	GNB4	GNB4	14597	-0.11	0.093	NO
77	GNG12	GNG12	GNG12	14695	-0.12	0.092	NO
78	CDX2	CDX2	CDX2	14837	-0.12	0.09	NO
79	ITPR2	ITPR2	ITPR2	14944	-0.12	0.09	NO
80	IQGAP1	IQGAP1	IQGAP1	15360	-0.14	0.073	NO
81	PLCB2	PLCB2	PLCB2	15634	-0.15	0.065	NO
82	ADRA2A	ADRA2A	ADRA2A	15806	-0.16	0.063	NO
83	CHRM3	CHRM3	CHRM3	15883	-0.16	0.066	NO
84	SLC2A1	SLC2A1	SLC2A1	16445	-0.2	0.044	NO
85	PLCB3	PLCB3	PLCB3	16825	-0.23	0.033	NO
86	AKAP5	AKAP5	AKAP5	16902	-0.23	0.038	NO
87	ITPR3	ITPR3	ITPR3	17475	-0.28	0.019	NO
88	GNA15	GNA15	GNA15	18012	-0.35	0.0051	NO
89	GATA4	GATA4	GATA4	18374	-0.44	0.0045	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CAMK2B	CAMK2B	CAMK2B	19	1.2	0.22	YES
2	MAPT	MAPT	MAPT	293	0.74	0.35	YES
3	F2	F2	F2	1125	0.39	0.38	YES
4	STAT4	STAT4	STAT4	1222	0.37	0.44	YES
5	AGT	AGT	AGT	1465	0.32	0.49	YES
6	GNAI1	GNAI1	GNAI1	1995	0.26	0.52	YES
7	HRAS	HRAS	HRAS	3964	0.12	0.43	NO
8	CALM1	CALM1	CALM1	4065	0.11	0.45	NO
9	STAT5B	STAT5B	STAT5B	4469	0.097	0.44	NO
10	CDK5	CDK5	CDK5	4604	0.093	0.45	NO
11	AGTR2	AGTR2	AGTR2	5064	0.079	0.44	NO
12	MAP2K2	MAP2K2	MAP2K2	5877	0.06	0.41	NO
13	GNA11	GNA11	GNA11	6709	0.043	0.38	NO
14	CAMK2G	CAMK2G	CAMK2G	6825	0.041	0.38	NO
15	FYN	FYN	FYN	7710	0.024	0.33	NO
16	PLCG1	PLCG1	PLCG1	7924	0.021	0.33	NO
17	KNG1	KNG1	KNG1	8538	0.011	0.29	NO
18	STAT3	STAT3	STAT3	9147	0.002	0.26	NO
19	GRB2	GRB2	GRB2	9153	0.0018	0.26	NO
20	CALM3	CALM3	CALM3	9256	0.00036	0.26	NO
21	CAMK2D	CAMK2D	CAMK2D	9257	0.00034	0.26	NO
22	PTK2B	PTK2B	PTK2B	9410	-0.0016	0.25	NO
23	GNB1	GNB1	GNB1	9761	-0.0071	0.23	NO
24	JAK2	JAK2	JAK2	9781	-0.0076	0.23	NO
25	CALM2	CALM2	CALM2	10029	-0.011	0.22	NO
26	MAP2K1	MAP2K1	MAP2K1	10405	-0.017	0.2	NO
27	MAPK1	MAPK1	MAPK1	11224	-0.031	0.16	NO
28	MAPK8	MAPK8	MAPK8	11334	-0.033	0.16	NO
29	STAT2	STAT2	STAT2	11477	-0.036	0.16	NO
30	MAPK3	MAPK3	MAPK3	11548	-0.037	0.17	NO
31	STAT5A	STAT5A	STAT5A	11584	-0.038	0.17	NO
32	SOS1	SOS1	SOS1	11656	-0.039	0.18	NO
33	MAPK14	MAPK14	MAPK14	12779	-0.061	0.13	NO
34	RAF1	RAF1	RAF1	13211	-0.071	0.12	NO
35	PRKCA	PRKCA	PRKCA	13493	-0.078	0.12	NO
36	CAMK2A	CAMK2A	CAMK2A	13497	-0.078	0.13	NO
37	PRKCB	PRKCB	PRKCB	13923	-0.091	0.13	NO
38	SHC1	SHC1	SHC1	14292	-0.1	0.13	NO
39	GNGT1	GNGT1	GNGT1	14480	-0.11	0.14	NO
40	STAT1	STAT1	STAT1	14843	-0.12	0.14	NO
41	MYLK	MYLK	MYLK	15090	-0.13	0.15	NO
42	STAT6	STAT6	STAT6	15688	-0.16	0.15	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MAPT	MAPT	MAPT	293	0.74	0.1	YES
2	BRSK1	BRSK1	BRSK1	509	0.6	0.19	YES
3	MAP2	MAP2	MAP2	681	0.52	0.26	YES
4	BRSK2	BRSK2	BRSK2	861	0.46	0.33	YES
5	ESR1	ESR1	ESR1	1043	0.41	0.38	YES
6	SMARCD3	SMARCD3	SMARCD3	2031	0.25	0.37	NO
7	SMAD4	SMAD4	SMAD4	3911	0.12	0.29	NO
8	SIK3	SIK3	SIK3	4185	0.11	0.29	NO
9	PRKACA	PRKACA	PRKACA	4439	0.098	0.29	NO
10	RPTOR	RPTOR	RPTOR	4847	0.085	0.28	NO
11	AKT1S1	AKT1S1	AKT1S1	5005	0.081	0.29	NO
12	PSEN2	PSEN2	PSEN2	5069	0.079	0.3	NO
13	STRADA	STRADA	STRADA	5167	0.076	0.3	NO
14	SIK2	SIK2	SIK2	5412	0.07	0.3	NO
15	MARK4	MARK4	MARK4	5642	0.065	0.3	NO
16	MLST8	MLST8	MLST8	5736	0.062	0.31	NO
17	STK11	STK11	STK11	5752	0.062	0.32	NO
18	YWHAE	YWHAE	YWHAE	5835	0.06	0.32	NO
19	TSC1	TSC1	TSC1	6062	0.056	0.32	NO
20	STK11IP	STK11IP	STK11IP	6560	0.046	0.3	NO
21	PRKAA2	PRKAA2	PRKAA2	6668	0.044	0.3	NO
22	PRKAG1	PRKAG1	PRKAG1	6859	0.04	0.3	NO
23	YWHAQ	YWHAQ	YWHAQ	7103	0.035	0.29	NO
24	TSC2	TSC2	TSC2	7346	0.031	0.28	NO
25	YWHAG	YWHAG	YWHAG	9307	-0.0004	0.17	NO
26	HSP90AA1	HSP90AA1	HSP90AA1	9328	-0.00067	0.17	NO
27	YWHAH	YWHAH	YWHAH	9428	-0.0018	0.17	NO
28	STRADB	STRADB	STRADB	9803	-0.0079	0.15	NO
29	CDC37	CDC37	CDC37	10041	-0.011	0.14	NO
30	PRKAB1	PRKAB1	PRKAB1	10795	-0.024	0.1	NO
31	YWHAB	YWHAB	YWHAB	11239	-0.032	0.081	NO
32	GSK3B	GSK3B	GSK3B	11461	-0.035	0.075	NO
33	MARK2	MARK2	MARK2	11476	-0.036	0.08	NO
34	CRTC2	CRTC2	CRTC2	11654	-0.039	0.076	NO
35	CTSD	CTSD	CTSD	11680	-0.04	0.082	NO
36	SIK1	SIK1	SIK1	11777	-0.041	0.083	NO
37	CREB1	CREB1	CREB1	12191	-0.049	0.068	NO
38	MTOR	MTOR	MTOR	12583	-0.057	0.056	NO
39	TP53	TP53	TP53	12788	-0.061	0.055	NO
40	PRKAA1	PRKAA1	PRKAA1	13550	-0.08	0.026	NO
41	YWHAZ	YWHAZ	YWHAZ	14377	-0.1	-0.0014	NO
42	CAB39	CAB39	CAB39	14723	-0.12	-0.0013	NO
43	MYC	MYC	MYC	15265	-0.14	-0.0085	NO
44	EZR	EZR	EZR	15827	-0.16	-0.013	NO
45	MST4	MST4	MST4	16706	-0.22	-0.026	NO
46	ETV4	ETV4	ETV4	17737	-0.31	-0.032	NO
47	SFN	SFN	SFN	18365	-0.44	0.005	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SH3GL2	SH3GL2	SH3GL2	45	1.1	0.2	YES
2	DNAJC6	DNAJC6	DNAJC6	245	0.77	0.33	YES
3	VAMP2	VAMP2	VAMP2	1921	0.26	0.28	NO
4	OCRL	OCRL	OCRL	2734	0.19	0.28	NO
5	NECAP1	NECAP1	NECAP1	3536	0.14	0.26	NO
6	TPD52	TPD52	TPD52	3826	0.12	0.26	NO
7	AP1S2	AP1S2	AP1S2	4012	0.11	0.27	NO
8	NAPA	NAPA	NAPA	4328	0.1	0.28	NO
9	BLOC1S1	BLOC1S1	BLOC1S1	4367	0.1	0.29	NO
10	HIP1R	HIP1R	HIP1R	4734	0.089	0.29	NO
11	DTNBP1	DTNBP1	DTNBP1	5208	0.075	0.28	NO
12	AP1S1	AP1S1	AP1S1	6094	0.055	0.24	NO
13	AP1M1	AP1M1	AP1M1	6321	0.05	0.24	NO
14	PLDN	PLDN	PLDN	6695	0.043	0.22	NO
15	SORT1	SORT1	SORT1	6748	0.042	0.23	NO
16	GNS	GNS	GNS	6867	0.04	0.23	NO
17	AP3B1	AP3B1	AP3B1	7123	0.035	0.22	NO
18	AP1B1	AP1B1	AP1B1	7374	0.03	0.21	NO
19	DNASE2	DNASE2	DNASE2	7456	0.029	0.22	NO
20	CLTA	CLTA	CLTA	7460	0.029	0.22	NO
21	GBF1	GBF1	GBF1	7600	0.026	0.22	NO
22	HSPA8	HSPA8	HSPA8	8218	0.016	0.19	NO
23	AP1M2	AP1M2	AP1M2	8438	0.013	0.18	NO
24	CLTC	CLTC	CLTC	8662	0.0093	0.17	NO
25	SNX2	SNX2	SNX2	8766	0.008	0.16	NO
26	M6PR	M6PR	M6PR	9557	-0.0039	0.12	NO
27	TGOLN2	TGOLN2	TGOLN2	9572	-0.0042	0.12	NO
28	ARF1	ARF1	ARF1	9741	-0.0068	0.11	NO
29	BLOC1S3	BLOC1S3	BLOC1S3	9955	-0.01	0.1	NO
30	RAB5C	RAB5C	RAB5C	10012	-0.011	0.1	NO
31	CPD	CPD	CPD	10053	-0.012	0.1	NO
32	GAK	GAK	GAK	10366	-0.017	0.088	NO
33	AP1G1	AP1G1	AP1G1	10631	-0.021	0.078	NO
34	VAMP7	VAMP7	VAMP7	10665	-0.022	0.08	NO
35	IGF2R	IGF2R	IGF2R	10679	-0.022	0.084	NO
36	SNAPIN	SNAPIN	SNAPIN	10957	-0.027	0.073	NO
37	FTL	FTL	FTL	11227	-0.031	0.064	NO
38	PUM1	PUM1	PUM1	11344	-0.033	0.064	NO
39	YIPF6	YIPF6	YIPF6	11735	-0.04	0.051	NO
40	FTH1	FTH1	FTH1	11754	-0.041	0.057	NO
41	ARRB1	ARRB1	ARRB1	11866	-0.043	0.059	NO
42	AP4E1	AP4E1	AP4E1	12087	-0.047	0.056	NO
43	TPD52L1	TPD52L1	TPD52L1	12403	-0.053	0.048	NO
44	TXNDC5	TXNDC5	TXNDC5	12793	-0.061	0.039	NO
45	PICALM	PICALM	PICALM	12920	-0.064	0.044	NO
46	SNX5	SNX5	SNX5	13032	-0.066	0.05	NO
47	TBC1D8B	TBC1D8B	TBC1D8B	13111	-0.068	0.058	NO
48	SNX9	SNX9	SNX9	13112	-0.068	0.071	NO
49	DNM2	DNM2	DNM2	13160	-0.07	0.081	NO
50	PIK3C2A	PIK3C2A	PIK3C2A	13202	-0.071	0.092	NO
51	STX4	STX4	STX4	13280	-0.072	0.1	NO
52	AP4B1	AP4B1	AP4B1	13471	-0.078	0.1	NO
53	CNO	CNO	CNO	13658	-0.083	0.11	NO
54	AP3S1	AP3S1	AP3S1	14002	-0.093	0.11	NO
55	CTSZ	CTSZ	CTSZ	14131	-0.097	0.12	NO
56	SH3D19	SH3D19	SH3D19	15350	-0.14	0.08	NO
57	TFRC	TFRC	TFRC	15466	-0.15	0.1	NO
58	VAMP8	VAMP8	VAMP8	15544	-0.15	0.12	NO
59	SNAP23	SNAP23	SNAP23	16256	-0.19	0.12	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus3 enriched pathways

Table 5. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus3. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
KEGG DNA REPLICATION	36	genes.ES.table	0.57	1.6	0.1	0.25	0.95	0.61	0.26	0.46	0.15	0.034
KEGG CELL CYCLE	118	genes.ES.table	0.54	1.7	0.035	0.35	0.73	0.4	0.2	0.32	0.12	0.084
KEGG P53 SIGNALING PATHWAY	67	genes.ES.table	0.54	1.8	0.004	0.48	0.58	0.42	0.15	0.36	0.13	0.1
BIOCARTA RACCYCD PATHWAY	26	genes.ES.table	0.5	1.7	0.023	0.32	0.73	0.58	0.33	0.39	0.11	0.075
PID P73PATHWAY	79	genes.ES.table	0.54	1.9	0.0041	0.7	0.41	0.33	0.13	0.29	0	0.16
PID E2F PATHWAY	70	genes.ES.table	0.49	1.6	0.07	0.25	0.94	0.29	0.15	0.24	0.14	0.04
PID ATR PATHWAY	39	genes.ES.table	0.57	1.6	0.08	0.24	0.94	0.38	0.14	0.33	0.14	0.038
PID FRA PATHWAY	37	genes.ES.table	0.65	1.6	0.008	0.24	0.9	0.35	0.086	0.32	0.12	0.044
PID MYC ACTIVPATHWAY	78	genes.ES.table	0.43	1.6	0.046	0.24	0.9	0.33	0.19	0.27	0.12	0.045
PID PLK1 PATHWAY	45	genes.ES.table	0.73	1.7	0.024	0.31	0.8	0.42	0.075	0.39	0.13	0.07

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CDC25C	CDC25C	CDC25C	214	0.37	0.057	YES
2	NEK2	NEK2	NEK2	278	0.34	0.12	YES
3	PKMYT1	PKMYT1	PKMYT1	350	0.32	0.17	YES
4	CCNB2	CCNB2	CCNB2	440	0.3	0.22	YES
5	PLK4	PLK4	PLK4	542	0.27	0.27	YES
6	E2F1	E2F1	E2F1	659	0.25	0.31	YES
7	PLK1	PLK1	PLK1	672	0.25	0.35	YES
8	CDK1	CDK1	CDK1	888	0.22	0.38	YES
9	CCNA2	CCNA2	CCNA2	939	0.21	0.42	YES
10	CCNB1	CCNB1	CCNB1	1102	0.19	0.44	YES
11	CDC25A	CDC25A	CDC25A	2038	0.12	0.42	YES
12	WEE1	WEE1	WEE1	2106	0.11	0.43	YES
13	CDK2	CDK2	CDK2	2260	0.11	0.44	YES
14	MNAT1	MNAT1	MNAT1	2403	0.098	0.45	YES
15	TUBA4A	TUBA4A	TUBA4A	2427	0.097	0.47	YES
16	E2F3	E2F3	E2F3	2606	0.09	0.48	YES
17	CSNK1E	CSNK1E	CSNK1E	2670	0.087	0.49	YES
18	AZI1	AZI1	AZI1	2760	0.084	0.5	YES
19	CENPJ	CENPJ	CENPJ	2823	0.082	0.51	YES
20	TUBB	TUBB	TUBB	3374	0.067	0.5	YES
21	CKAP5	CKAP5	CKAP5	3467	0.065	0.5	YES
22	CDK7	CDK7	CDK7	3599	0.061	0.51	YES
23	XPO1	XPO1	XPO1	3930	0.054	0.5	YES
24	DYNC1I2	DYNC1I2	DYNC1I2	4015	0.052	0.5	YES
25	YWHAG	YWHAG	YWHAG	4091	0.05	0.51	YES
26	TUBG1	TUBG1	TUBG1	4092	0.05	0.52	YES
27	HSP90AA1	HSP90AA1	HSP90AA1	4138	0.05	0.52	YES
28	NUMA1	NUMA1	NUMA1	4615	0.041	0.51	NO
29	NEDD1	NEDD1	NEDD1	4879	0.037	0.5	NO
30	CETN2	CETN2	CETN2	4960	0.036	0.5	NO
31	CEP250	CEP250	CEP250	5045	0.035	0.5	NO
32	CEP70	CEP70	CEP70	5156	0.033	0.5	NO
33	CEP72	CEP72	CEP72	5180	0.033	0.51	NO
34	HAUS2	HAUS2	HAUS2	5457	0.029	0.5	NO
35	CDC25B	CDC25B	CDC25B	6043	0.021	0.47	NO
36	DYNC1H1	DYNC1H1	DYNC1H1	6188	0.02	0.47	NO
37	CLASP1	CLASP1	CLASP1	6661	0.014	0.44	NO
38	PPP2R1A	PPP2R1A	PPP2R1A	6745	0.014	0.44	NO
39	DYNLL1	DYNLL1	DYNLL1	6847	0.012	0.44	NO
40	MAPRE1	MAPRE1	MAPRE1	6962	0.011	0.43	NO
41	FGFR1OP	FGFR1OP	FGFR1OP	6971	0.011	0.44	NO
42	DCTN1	DCTN1	DCTN1	7237	0.0084	0.42	NO
43	CEP63	CEP63	CEP63	7355	0.0071	0.42	NO
44	CEP135	CEP135	CEP135	7416	0.0064	0.42	NO
45	TUBA1A	TUBA1A	TUBA1A	7597	0.0042	0.41	NO
46	CEP192	CEP192	CEP192	7810	0.0016	0.4	NO
47	CSNK1D	CSNK1D	CSNK1D	7864	0.001	0.39	NO
48	TUBGCP2	TUBGCP2	TUBGCP2	8056	-0.00092	0.38	NO
49	ALMS1	ALMS1	ALMS1	8154	-0.0019	0.38	NO
50	TUBGCP5	TUBGCP5	TUBGCP5	8299	-0.0037	0.37	NO
51	YWHAE	YWHAE	YWHAE	8418	-0.005	0.36	NO
52	CDK5RAP2	CDK5RAP2	CDK5RAP2	8452	-0.0054	0.36	NO
53	NINL	NINL	NINL	8485	-0.0057	0.36	NO
54	SDCCAG8	SDCCAG8	SDCCAG8	8760	-0.0086	0.35	NO
55	TUBG2	TUBG2	TUBG2	8762	-0.0086	0.35	NO
56	ACTR1A	ACTR1A	ACTR1A	8781	-0.0088	0.35	NO
57	CEP76	CEP76	CEP76	8956	-0.011	0.34	NO
58	SSNA1	SSNA1	SSNA1	9144	-0.013	0.34	NO
59	CEP164	CEP164	CEP164	9366	-0.015	0.33	NO
60	CCNH	CCNH	CCNH	9461	-0.016	0.33	NO
61	DCTN2	DCTN2	DCTN2	9995	-0.022	0.3	NO
62	OFD1	OFD1	OFD1	10006	-0.022	0.3	NO
63	CEP57	CEP57	CEP57	10044	-0.023	0.31	NO
64	CEP290	CEP290	CEP290	10516	-0.028	0.29	NO
65	TUBGCP3	TUBGCP3	TUBGCP3	11043	-0.036	0.26	NO
66	TUBGCP6	TUBGCP6	TUBGCP6	11074	-0.036	0.27	NO
67	PRKACA	PRKACA	PRKACA	11373	-0.04	0.26	NO
68	AKAP9	AKAP9	AKAP9	11420	-0.041	0.26	NO
69	DCTN3	DCTN3	DCTN3	12060	-0.052	0.24	NO
70	PCM1	PCM1	PCM1	12166	-0.054	0.24	NO
71	PAFAH1B1	PAFAH1B1	PAFAH1B1	12209	-0.055	0.25	NO
72	PCNT	PCNT	PCNT	12274	-0.057	0.26	NO
73	CCNA1	CCNA1	CCNA1	15153	-0.15	0.13	NO
74	PRKAR2B	PRKAR2B	PRKAR2B	16712	-0.26	0.095	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	S100A2	S100A2	S100A2	33	0.56	0.063	YES
2	TP73	TP73	TP73	54	0.5	0.12	YES
3	TP63	TP63	TP63	115	0.44	0.17	YES
4	BUB1	BUB1	BUB1	416	0.3	0.18	YES
5	SFN	SFN	SFN	450	0.29	0.22	YES
6	IL1RAP	IL1RAP	IL1RAP	465	0.29	0.25	YES
7	TP53AIP1	TP53AIP1	TP53AIP1	484	0.28	0.28	YES
8	RAD51	RAD51	RAD51	517	0.28	0.31	YES
9	PLK1	PLK1	PLK1	672	0.25	0.33	YES
10	WT1	WT1	WT1	773	0.23	0.35	YES
11	CDK1	CDK1	CDK1	888	0.22	0.37	YES
12	CCNA2	CCNA2	CCNA2	939	0.21	0.39	YES
13	ADA	ADA	ADA	1031	0.2	0.41	YES
14	CCNE2	CCNE2	CCNE2	1067	0.2	0.43	YES
15	CCNB1	CCNB1	CCNB1	1102	0.19	0.45	YES
16	CLCA2	CLCA2	CLCA2	1224	0.18	0.46	YES
17	CHEK1	CHEK1	CHEK1	1292	0.17	0.48	YES
18	BRCA2	BRCA2	BRCA2	1413	0.16	0.49	YES
19	SERPINE1	SERPINE1	SERPINE1	1486	0.16	0.5	YES
20	JAG2	JAG2	JAG2	1673	0.14	0.51	YES
21	CDK6	CDK6	CDK6	2115	0.11	0.5	YES
22	PLK3	PLK3	PLK3	2188	0.11	0.51	YES
23	BBC3	BBC3	BBC3	2198	0.11	0.52	YES
24	CDK2	CDK2	CDK2	2260	0.11	0.53	YES
25	YAP1	YAP1	YAP1	2287	0.1	0.54	YES
26	HSF1	HSF1	HSF1	2415	0.098	0.54	YES
27	FBXO45	FBXO45	FBXO45	2657	0.088	0.54	NO
28	PML	PML	PML	3179	0.072	0.52	NO
29	IL4R	IL4R	IL4R	3219	0.071	0.53	NO
30	TP53I3	TP53I3	TP53I3	3794	0.057	0.5	NO
31	CASP2	CASP2	CASP2	3859	0.055	0.5	NO
32	ITCH	ITCH	ITCH	3867	0.055	0.51	NO
33	RELA	RELA	RELA	4309	0.046	0.49	NO
34	SP1	SP1	SP1	4780	0.039	0.47	NO
35	MDM2	MDM2	MDM2	4867	0.037	0.47	NO
36	BCL2L11	BCL2L11	BCL2L11	5136	0.034	0.46	NO
37	BUB3	BUB3	BUB3	5218	0.032	0.46	NO
38	FASN	FASN	FASN	5233	0.032	0.46	NO
39	BAK1	BAK1	BAK1	5234	0.032	0.46	NO
40	CDKN1A	CDKN1A	CDKN1A	6056	0.021	0.42	NO
41	PEA15	PEA15	PEA15	6289	0.018	0.41	NO
42	MAPK14	MAPK14	MAPK14	6355	0.018	0.41	NO
43	DEDD	DEDD	DEDD	6409	0.017	0.41	NO
44	MYC	MYC	MYC	7176	0.009	0.37	NO
45	TUBA1A	TUBA1A	TUBA1A	7597	0.0042	0.35	NO
46	BAX	BAX	BAX	7713	0.0028	0.34	NO
47	FLOT2	FLOT2	FLOT2	7912	0.00052	0.33	NO
48	UBE4B	UBE4B	UBE4B	8001	-0.00039	0.32	NO
49	EP300	EP300	EP300	8021	-0.00054	0.32	NO
50	ABL1	ABL1	ABL1	8208	-0.0025	0.31	NO
51	FAS	FAS	FAS	8537	-0.0062	0.3	NO
52	AFP	AFP	AFP	8794	-0.0089	0.28	NO
53	GNB2L1	GNB2L1	GNB2L1	8862	-0.0097	0.28	NO
54	JAK1	JAK1	JAK1	9052	-0.012	0.27	NO
55	NDUFS2	NDUFS2	NDUFS2	9758	-0.02	0.24	NO
56	KAT5	KAT5	KAT5	9806	-0.02	0.24	NO
57	MAPK11	MAPK11	MAPK11	10045	-0.023	0.23	NO
58	RB1	RB1	RB1	10458	-0.027	0.21	NO
59	FOXO3	FOXO3	FOXO3	10875	-0.033	0.19	NO
60	BIN1	BIN1	BIN1	11231	-0.038	0.17	NO
61	RCHY1	RCHY1	RCHY1	11436	-0.042	0.17	NO
62	PFDN5	PFDN5	PFDN5	11597	-0.044	0.16	NO
63	AEN	AEN	AEN	11645	-0.045	0.16	NO
64	DCP1B	DCP1B	DCP1B	11652	-0.045	0.17	NO
65	RNF43	RNF43	RNF43	11700	-0.046	0.17	NO
66	PIN1	PIN1	PIN1	11995	-0.051	0.16	NO
67	GRAMD4	GRAMD4	GRAMD4	12007	-0.051	0.17	NO
68	SIRT1	SIRT1	SIRT1	12285	-0.057	0.16	NO
69	HEY2	HEY2	HEY2	12572	-0.063	0.15	NO
70	SERPINA1	SERPINA1	SERPINA1	12801	-0.068	0.15	NO
71	NEDD4L	NEDD4L	NEDD4L	12909	-0.07	0.15	NO
72	HAGH	HAGH	HAGH	13411	-0.083	0.13	NO
73	GDF15	GDF15	GDF15	13498	-0.086	0.14	NO
74	WWOX	WWOX	WWOX	13747	-0.093	0.13	NO
75	GATA1	GATA1	GATA1	14828	-0.14	0.09	NO
76	PRKACB	PRKACB	PRKACB	14965	-0.14	0.099	NO
77	PPAP2A	PPAP2A	PPAP2A	15049	-0.15	0.11	NO
78	NTRK1	NTRK1	NTRK1	16684	-0.26	0.052	NO
79	D4S234E	D4S234E	D4S234E	17796	-0.39	0.036	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	KIF18A	KIF18A	KIF18A	148	0.41	0.0039	YES
2	SPC24	SPC24	SPC24	165	0.4	0.015	YES
3	CDC25C	CDC25C	CDC25C	214	0.37	0.023	YES
4	BIRC5	BIRC5	BIRC5	220	0.37	0.034	YES
5	MCM10	MCM10	MCM10	250	0.35	0.042	YES
6	CENPA	CENPA	CENPA	263	0.35	0.052	YES
7	CENPI	CENPI	CENPI	269	0.34	0.062	YES
8	HJURP	HJURP	HJURP	273	0.34	0.072	YES
9	NEK2	NEK2	NEK2	278	0.34	0.082	YES
10	OIP5	OIP5	OIP5	280	0.34	0.092	YES
11	KIF20A	KIF20A	KIF20A	300	0.34	0.1	YES
12	HIST1H2BC	HIST1H2BC	HIST1H2BC	319	0.33	0.11	YES
13	UBE2C	UBE2C	UBE2C	333	0.32	0.12	YES
14	SGOL1	SGOL1	SGOL1	335	0.32	0.13	YES
15	PKMYT1	PKMYT1	PKMYT1	350	0.32	0.14	YES
16	HIST1H2BO	HIST1H2BO	HIST1H2BO	351	0.32	0.15	YES
17	KIF23	KIF23	KIF23	354	0.32	0.16	YES
18	CDC45	CDC45	CDC45	373	0.31	0.16	YES
19	CDC20	CDC20	CDC20	395	0.3	0.17	YES
20	KIF2C	KIF2C	KIF2C	401	0.3	0.18	YES
21	ERCC6L	ERCC6L	ERCC6L	407	0.3	0.19	YES
22	HIST1H2BJ	HIST1H2BJ	HIST1H2BJ	410	0.3	0.2	YES
23	BUB1	BUB1	BUB1	416	0.3	0.21	YES
24	CCNB2	CCNB2	CCNB2	440	0.3	0.21	YES
25	CENPK	CENPK	CENPK	449	0.29	0.22	YES
26	HIST1H2BD	HIST1H2BD	HIST1H2BD	469	0.29	0.23	YES
27	PLK4	PLK4	PLK4	542	0.27	0.23	YES
28	CASC5	CASC5	CASC5	584	0.27	0.24	YES
29	HIST1H4E	HIST1H4E	HIST1H4E	587	0.27	0.25	YES
30	HIST1H4I	HIST1H4I	HIST1H4I	597	0.26	0.25	YES
31	BUB1B	BUB1B	BUB1B	608	0.26	0.26	YES
32	AURKB	AURKB	AURKB	625	0.26	0.27	YES
33	MYBL2	MYBL2	MYBL2	632	0.26	0.28	YES
34	E2F1	E2F1	E2F1	659	0.25	0.28	YES
35	NUF2	NUF2	NUF2	664	0.25	0.29	YES
36	PLK1	PLK1	PLK1	672	0.25	0.3	YES
37	SMC1B	SMC1B	SMC1B	685	0.25	0.3	YES
38	HIST3H2BB	HIST3H2BB	HIST3H2BB	713	0.24	0.31	YES
39	CDC6	CDC6	CDC6	762	0.24	0.31	YES
40	HIST1H2BG	HIST1H2BG	HIST1H2BG	767	0.23	0.32	YES
41	CDT1	CDT1	CDT1	771	0.23	0.32	YES
42	HIST1H2AJ	HIST1H2AJ	HIST1H2AJ	818	0.23	0.33	YES
43	HIST1H2BF	HIST1H2BF	HIST1H2BF	843	0.22	0.33	YES
44	POLE2	POLE2	POLE2	857	0.22	0.34	YES
45	HIST1H2AD	HIST1H2AD	HIST1H2AD	874	0.22	0.34	YES
46	GINS4	GINS4	GINS4	875	0.22	0.35	YES
47	HIST1H2BM	HIST1H2BM	HIST1H2BM	876	0.22	0.36	YES
48	AURKA	AURKA	AURKA	877	0.22	0.36	YES
49	PTTG1	PTTG1	PTTG1	884	0.22	0.37	YES
50	CDK1	CDK1	CDK1	888	0.22	0.38	YES
51	CCNE1	CCNE1	CCNE1	930	0.22	0.38	YES
52	CCNA2	CCNA2	CCNA2	939	0.21	0.39	YES
53	HIST1H2AE	HIST1H2AE	HIST1H2AE	971	0.21	0.39	YES
54	NDC80	NDC80	NDC80	979	0.21	0.4	YES
55	HIST2H2AA3	HIST2H2AA3	HIST2H2AA3	988	0.21	0.4	YES
56	SKA1	SKA1	SKA1	993	0.21	0.41	YES
57	MCM2	MCM2	MCM2	1030	0.2	0.41	YES
58	HIST1H2BN	HIST1H2BN	HIST1H2BN	1032	0.2	0.42	YES
59	RRM2	RRM2	RRM2	1040	0.2	0.42	YES
60	CCNE2	CCNE2	CCNE2	1067	0.2	0.43	YES
61	HIST1H4H	HIST1H4H	HIST1H4H	1084	0.19	0.43	YES
62	GINS2	GINS2	GINS2	1087	0.19	0.44	YES
63	MCM4	MCM4	MCM4	1089	0.19	0.44	YES
64	MAD2L1	MAD2L1	MAD2L1	1091	0.19	0.45	YES
65	HIST1H4B	HIST1H4B	HIST1H4B	1096	0.19	0.46	YES
66	CCNB1	CCNB1	CCNB1	1102	0.19	0.46	YES
67	GINS1	GINS1	GINS1	1126	0.19	0.47	YES
68	CDCA8	CDCA8	CDCA8	1135	0.19	0.47	YES
69	HIST1H2BE	HIST1H2BE	HIST1H2BE	1175	0.18	0.47	YES
70	CENPM	CENPM	CENPM	1250	0.18	0.48	YES
71	HIST1H2BL	HIST1H2BL	HIST1H2BL	1280	0.18	0.48	YES
72	CHEK1	CHEK1	CHEK1	1292	0.17	0.48	YES
73	HIST1H4D	HIST1H4D	HIST1H4D	1296	0.17	0.49	YES
74	KNTC1	KNTC1	KNTC1	1299	0.17	0.49	YES
75	HIST2H4A	HIST2H4A	HIST2H4A	1312	0.17	0.5	YES
76	SGOL2	SGOL2	SGOL2	1338	0.17	0.5	YES
77	RFC4	RFC4	RFC4	1365	0.17	0.5	YES
78	MLF1IP	MLF1IP	MLF1IP	1380	0.16	0.51	YES
79	CENPH	CENPH	CENPH	1442	0.16	0.51	YES
80	HIST2H2BE	HIST2H2BE	HIST2H2BE	1457	0.16	0.51	YES
81	CCND1	CCND1	CCND1	1526	0.15	0.52	YES
82	ZWINT	ZWINT	ZWINT	1606	0.15	0.52	YES
83	CKS1B	CKS1B	CKS1B	1615	0.14	0.52	YES
84	SYCP2	SYCP2	SYCP2	1632	0.14	0.52	YES
85	TYMS	TYMS	TYMS	1647	0.14	0.52	YES
86	SPC25	SPC25	SPC25	1784	0.13	0.52	YES
87	TERT	TERT	TERT	1979	0.12	0.51	YES
88	DNA2	DNA2	DNA2	2018	0.12	0.52	YES
89	CDC25A	CDC25A	CDC25A	2038	0.12	0.52	YES
90	INCENP	INCENP	INCENP	2105	0.11	0.52	YES
91	WEE1	WEE1	WEE1	2106	0.11	0.52	YES
92	CDK6	CDK6	CDK6	2115	0.11	0.52	YES
93	CCDC99	CCDC99	CCDC99	2153	0.11	0.52	YES
94	CENPN	CENPN	CENPN	2235	0.11	0.52	YES
95	CDK2	CDK2	CDK2	2260	0.11	0.53	YES
96	LMNB1	LMNB1	LMNB1	2264	0.11	0.53	YES
97	E2F2	E2F2	E2F2	2298	0.1	0.53	YES
98	HIST1H4J	HIST1H4J	HIST1H4J	2300	0.1	0.53	YES
99	HIST1H2BK	HIST1H2BK	HIST1H2BK	2354	0.1	0.53	YES
100	ZWILCH	ZWILCH	ZWILCH	2371	0.1	0.54	YES
101	MNAT1	MNAT1	MNAT1	2403	0.098	0.54	YES
102	CENPO	CENPO	CENPO	2424	0.097	0.54	YES
103	TUBA4A	TUBA4A	TUBA4A	2427	0.097	0.54	YES
104	RFC2	RFC2	RFC2	2435	0.097	0.54	YES
105	H2AFX	H2AFX	H2AFX	2484	0.095	0.54	YES
106	HIST1H2AC	HIST1H2AC	HIST1H2AC	2490	0.094	0.55	YES
107	RUVBL1	RUVBL1	RUVBL1	2507	0.094	0.55	YES
108	POLD1	POLD1	POLD1	2510	0.094	0.55	YES
109	NUP107	NUP107	NUP107	2554	0.092	0.55	YES
110	LIN9	LIN9	LIN9	2577	0.09	0.55	YES
111	E2F3	E2F3	E2F3	2606	0.09	0.55	YES
112	PSMD2	PSMD2	PSMD2	2609	0.089	0.56	YES
113	RBL1	RBL1	RBL1	2663	0.087	0.56	YES
114	CSNK1E	CSNK1E	CSNK1E	2670	0.087	0.56	YES
115	MCM7	MCM7	MCM7	2678	0.087	0.56	YES
116	CDC7	CDC7	CDC7	2696	0.086	0.56	YES
117	CHEK2	CHEK2	CHEK2	2710	0.086	0.56	YES
118	RCC2	RCC2	RCC2	2753	0.084	0.56	YES
119	AZI1	AZI1	AZI1	2760	0.084	0.57	YES
120	HIST4H4	HIST4H4	HIST4H4	2765	0.084	0.57	YES
121	FEN1	FEN1	FEN1	2771	0.084	0.57	YES
122	CENPJ	CENPJ	CENPJ	2823	0.082	0.57	YES
123	DSN1	DSN1	DSN1	2848	0.082	0.57	YES
124	PSMD14	PSMD14	PSMD14	2871	0.081	0.57	YES
125	MCM6	MCM6	MCM6	2932	0.079	0.57	YES
126	CDKN2B	CDKN2B	CDKN2B	2966	0.078	0.57	YES
127	RUVBL2	RUVBL2	RUVBL2	3055	0.075	0.57	YES
128	NUP85	NUP85	NUP85	3129	0.073	0.57	YES
129	HIST3H3	HIST3H3	HIST3H3	3140	0.073	0.57	YES
130	FKBP6	FKBP6	FKBP6	3166	0.072	0.57	YES
131	PRIM2	PRIM2	PRIM2	3200	0.071	0.57	YES
132	MCM8	MCM8	MCM8	3214	0.071	0.57	YES
133	CENPL	CENPL	CENPL	3241	0.07	0.57	YES
134	CENPP	CENPP	CENPP	3309	0.068	0.57	YES
135	PSMD12	PSMD12	PSMD12	3311	0.068	0.57	YES
136	TUBB	TUBB	TUBB	3374	0.067	0.57	YES
137	CDKN2D	CDKN2D	CDKN2D	3379	0.067	0.57	YES
138	RPA3	RPA3	RPA3	3390	0.067	0.57	YES
139	MCM5	MCM5	MCM5	3395	0.067	0.57	YES
140	CKAP5	CKAP5	CKAP5	3467	0.065	0.57	YES
141	SKP2	SKP2	SKP2	3471	0.065	0.57	YES
142	H2AFZ	H2AFZ	H2AFZ	3541	0.063	0.57	YES
143	RANGAP1	RANGAP1	RANGAP1	3562	0.062	0.57	YES
144	RFC5	RFC5	RFC5	3577	0.062	0.57	YES
145	PPP2R2A	PPP2R2A	PPP2R2A	3596	0.061	0.58	YES
146	CDK7	CDK7	CDK7	3599	0.061	0.58	YES
147	PSMD7	PSMD7	PSMD7	3660	0.06	0.58	YES
148	UBE2E1	UBE2E1	UBE2E1	3695	0.059	0.58	YES
149	HSPA2	HSPA2	HSPA2	3698	0.059	0.58	YES
150	PSMD11	PSMD11	PSMD11	3713	0.058	0.58	YES
151	TAOK1	TAOK1	TAOK1	3723	0.058	0.58	YES
152	NUP37	NUP37	NUP37	3731	0.058	0.58	YES
153	LIG1	LIG1	LIG1	3804	0.056	0.58	NO
154	XPO1	XPO1	XPO1	3930	0.054	0.57	NO
155	BRCA1	BRCA1	BRCA1	3945	0.053	0.57	NO
156	LMNA	LMNA	LMNA	4005	0.052	0.57	NO
157	DYNC1I2	DYNC1I2	DYNC1I2	4015	0.052	0.57	NO
158	UBE2I	UBE2I	UBE2I	4038	0.052	0.57	NO
159	RSF1	RSF1	RSF1	4047	0.051	0.57	NO
160	PSMA1	PSMA1	PSMA1	4051	0.051	0.58	NO
161	ZW10	ZW10	ZW10	4053	0.051	0.58	NO
162	ANAPC11	ANAPC11	ANAPC11	4073	0.051	0.58	NO
163	YWHAG	YWHAG	YWHAG	4091	0.05	0.58	NO
164	TUBG1	TUBG1	TUBG1	4092	0.05	0.58	NO
165	HSP90AA1	HSP90AA1	HSP90AA1	4138	0.05	0.58	NO
166	POLD4	POLD4	POLD4	4167	0.049	0.58	NO
167	PCNA	PCNA	PCNA	4202	0.048	0.58	NO
168	TK2	TK2	TK2	4225	0.048	0.58	NO
169	PSMB2	PSMB2	PSMB2	4258	0.047	0.58	NO
170	PSMA7	PSMA7	PSMA7	4327	0.046	0.58	NO
171	DBF4	DBF4	DBF4	4330	0.046	0.58	NO
172	TEX12	TEX12	TEX12	4343	0.046	0.58	NO
173	RFC3	RFC3	RFC3	4368	0.045	0.58	NO
174	ANAPC1	ANAPC1	ANAPC1	4384	0.045	0.58	NO
175	PSMA5	PSMA5	PSMA5	4401	0.045	0.58	NO
176	ACD	ACD	ACD	4432	0.044	0.58	NO
177	CENPQ	CENPQ	CENPQ	4447	0.044	0.58	NO
178	LIN37	LIN37	LIN37	4497	0.043	0.58	NO
179	RAD21	RAD21	RAD21	4525	0.043	0.58	NO
180	HIST1H2AB	HIST1H2AB	HIST1H2AB	4553	0.042	0.58	NO
181	PSMA6	PSMA6	PSMA6	4582	0.042	0.58	NO
182	NUMA1	NUMA1	NUMA1	4615	0.041	0.58	NO
183	UBE2D1	UBE2D1	UBE2D1	4616	0.041	0.58	NO
184	MAD1L1	MAD1L1	MAD1L1	4667	0.04	0.58	NO
185	CLIP1	CLIP1	CLIP1	4673	0.04	0.58	NO
186	ATR	ATR	ATR	4674	0.04	0.58	NO
187	PPP2R5E	PPP2R5E	PPP2R5E	4701	0.04	0.58	NO
188	POLA2	POLA2	POLA2	4740	0.039	0.58	NO
189	PSMD8	PSMD8	PSMD8	4821	0.038	0.57	NO
190	STAG1	STAG1	STAG1	4835	0.038	0.57	NO
191	MDM2	MDM2	MDM2	4867	0.037	0.57	NO
192	NEDD1	NEDD1	NEDD1	4879	0.037	0.57	NO
193	ITGB3BP	ITGB3BP	ITGB3BP	4881	0.037	0.57	NO
194	CETN2	CETN2	CETN2	4960	0.036	0.57	NO
195	CEP250	CEP250	CEP250	5045	0.035	0.57	NO
196	PSMD13	PSMD13	PSMD13	5082	0.034	0.57	NO
197	POLE	POLE	POLE	5120	0.034	0.57	NO
198	CEP70	CEP70	CEP70	5156	0.033	0.56	NO
199	CEP72	CEP72	CEP72	5180	0.033	0.56	NO
200	PSMC3	PSMC3	PSMC3	5187	0.033	0.56	NO
201	BUB3	BUB3	BUB3	5218	0.032	0.56	NO
202	PSMC1	PSMC1	PSMC1	5255	0.032	0.56	NO
203	RAD9A	RAD9A	RAD9A	5260	0.032	0.56	NO
204	PSMD1	PSMD1	PSMD1	5280	0.032	0.56	NO
205	POT1	POT1	POT1	5412	0.03	0.56	NO
206	PSMC6	PSMC6	PSMC6	5442	0.029	0.56	NO
207	HAUS2	HAUS2	HAUS2	5457	0.029	0.56	NO
208	CDC23	CDC23	CDC23	5505	0.028	0.56	NO
209	KIF2A	KIF2A	KIF2A	5545	0.028	0.55	NO
210	PSMD5	PSMD5	PSMD5	5561	0.028	0.55	NO
211	PSME4	PSME4	PSME4	5630	0.027	0.55	NO
212	ANAPC10	ANAPC10	ANAPC10	5665	0.026	0.55	NO
213	PSMC4	PSMC4	PSMC4	5669	0.026	0.55	NO
214	DHFR	DHFR	DHFR	5672	0.026	0.55	NO
215	TFDP1	TFDP1	TFDP1	5771	0.025	0.55	NO
216	PSMA3	PSMA3	PSMA3	5831	0.024	0.54	NO
217	PSMD4	PSMD4	PSMD4	5878	0.024	0.54	NO
218	CENPT	CENPT	CENPT	5884	0.023	0.54	NO
219	CDK4	CDK4	CDK4	5928	0.023	0.54	NO
220	CDC25B	CDC25B	CDC25B	6043	0.021	0.54	NO
221	PSMD10	PSMD10	PSMD10	6055	0.021	0.54	NO
222	CDKN1A	CDKN1A	CDKN1A	6056	0.021	0.54	NO
223	SKA2	SKA2	SKA2	6077	0.021	0.54	NO
224	CDKN2A	CDKN2A	CDKN2A	6115	0.021	0.53	NO
225	SEC13	SEC13	SEC13	6170	0.02	0.53	NO
226	PPP2R5B	PPP2R5B	PPP2R5B	6173	0.02	0.53	NO
227	DYNC1H1	DYNC1H1	DYNC1H1	6188	0.02	0.53	NO
228	PSMD3	PSMD3	PSMD3	6194	0.02	0.53	NO
229	NUDC	NUDC	NUDC	6225	0.019	0.53	NO
230	CDC27	CDC27	CDC27	6249	0.019	0.53	NO
231	PSMA2	PSMA2	PSMA2	6271	0.019	0.53	NO
232	PSMA4	PSMA4	PSMA4	6379	0.018	0.52	NO
233	PSMB5	PSMB5	PSMB5	6385	0.018	0.52	NO
234	PSMB3	PSMB3	PSMB3	6437	0.017	0.52	NO
235	SUN2	SUN2	SUN2	6458	0.017	0.52	NO
236	NPM1	NPM1	NPM1	6558	0.016	0.52	NO
237	NDEL1	NDEL1	NDEL1	6654	0.014	0.51	NO
238	CLASP1	CLASP1	CLASP1	6661	0.014	0.51	NO
239	HDAC1	HDAC1	HDAC1	6671	0.014	0.51	NO
240	PSMB9	PSMB9	PSMB9	6695	0.014	0.51	NO
241	E2F4	E2F4	E2F4	6720	0.014	0.51	NO
242	PPP2R1A	PPP2R1A	PPP2R1A	6745	0.014	0.51	NO
243	PPP2CA	PPP2CA	PPP2CA	6752	0.014	0.51	NO
244	PSMB7	PSMB7	PSMB7	6763	0.013	0.51	NO
245	SEH1L	SEH1L	SEH1L	6823	0.013	0.51	NO
246	DYNLL1	DYNLL1	DYNLL1	6847	0.012	0.5	NO
247	PSMB4	PSMB4	PSMB4	6883	0.012	0.5	NO
248	MAPRE1	MAPRE1	MAPRE1	6962	0.011	0.5	NO
249	FGFR1OP	FGFR1OP	FGFR1OP	6971	0.011	0.5	NO
250	POLD2	POLD2	POLD2	7077	0.01	0.49	NO
251	RBBP4	RBBP4	RBBP4	7143	0.0094	0.49	NO
252	PSMD9	PSMD9	PSMD9	7162	0.0092	0.49	NO
253	MYC	MYC	MYC	7176	0.009	0.49	NO
254	PSMC2	PSMC2	PSMC2	7201	0.0088	0.49	NO
255	DCTN1	DCTN1	DCTN1	7237	0.0084	0.49	NO
256	SMARCA5	SMARCA5	SMARCA5	7244	0.0083	0.49	NO
257	RBBP7	RBBP7	RBBP7	7338	0.0073	0.48	NO
258	CEP63	CEP63	CEP63	7355	0.0071	0.48	NO
259	RAD1	RAD1	RAD1	7386	0.0068	0.48	NO
260	PSMB8	PSMB8	PSMB8	7411	0.0065	0.48	NO
261	CEP135	CEP135	CEP135	7416	0.0064	0.48	NO
262	PSMC5	PSMC5	PSMC5	7439	0.0062	0.48	NO
263	DKC1	DKC1	DKC1	7446	0.0061	0.48	NO
264	HIST1H4A	HIST1H4A	HIST1H4A	7530	0.0051	0.47	NO
265	TUBA1A	TUBA1A	TUBA1A	7597	0.0042	0.47	NO
266	PRIM1	PRIM1	PRIM1	7684	0.0032	0.46	NO
267	PPP2CB	PPP2CB	PPP2CB	7803	0.0017	0.46	NO
268	CEP192	CEP192	CEP192	7810	0.0016	0.46	NO
269	SYNE2	SYNE2	SYNE2	7846	0.0012	0.46	NO
270	CSNK1D	CSNK1D	CSNK1D	7864	0.001	0.46	NO
271	MCM3	MCM3	MCM3	8011	-0.00046	0.45	NO
272	TUBGCP2	TUBGCP2	TUBGCP2	8056	-0.00092	0.44	NO
273	PPP2R5C	PPP2R5C	PPP2R5C	8066	-0.00098	0.44	NO
274	PSME2	PSME2	PSME2	8112	-0.0015	0.44	NO
275	ALMS1	ALMS1	ALMS1	8154	-0.0019	0.44	NO
276	LIN54	LIN54	LIN54	8197	-0.0024	0.44	NO
277	AHCTF1	AHCTF1	AHCTF1	8198	-0.0024	0.44	NO
278	PSMF1	PSMF1	PSMF1	8251	-0.003	0.43	NO
279	SKP1	SKP1	SKP1	8277	-0.0034	0.43	NO
280	TUBGCP5	TUBGCP5	TUBGCP5	8299	-0.0037	0.43	NO
281	NHP2	NHP2	NHP2	8360	-0.0044	0.43	NO
282	YWHAE	YWHAE	YWHAE	8418	-0.005	0.43	NO
283	PSME1	PSME1	PSME1	8420	-0.005	0.43	NO
284	CDK5RAP2	CDK5RAP2	CDK5RAP2	8452	-0.0054	0.42	NO
285	NINL	NINL	NINL	8485	-0.0057	0.42	NO
286	TERF1	TERF1	TERF1	8486	-0.0057	0.42	NO
287	E2F5	E2F5	E2F5	8487	-0.0058	0.42	NO
288	ATRIP	ATRIP	ATRIP	8697	-0.0079	0.41	NO
289	SDCCAG8	SDCCAG8	SDCCAG8	8760	-0.0086	0.41	NO
290	TUBG2	TUBG2	TUBG2	8762	-0.0086	0.41	NO
291	ACTR1A	ACTR1A	ACTR1A	8781	-0.0088	0.41	NO
292	FBXO5	FBXO5	FBXO5	8887	-0.01	0.4	NO
293	SMC3	SMC3	SMC3	8889	-0.01	0.4	NO
294	HUS1	HUS1	HUS1	8899	-0.01	0.4	NO
295	STAG2	STAG2	STAG2	8921	-0.01	0.4	NO
296	RPS27A	RPS27A	RPS27A	8932	-0.01	0.4	NO
297	CEP76	CEP76	CEP76	8956	-0.011	0.4	NO
298	PPP2R5D	PPP2R5D	PPP2R5D	8989	-0.011	0.4	NO
299	DIDO1	DIDO1	DIDO1	9010	-0.011	0.4	NO
300	CUL1	CUL1	CUL1	9026	-0.012	0.4	NO
301	RPA2	RPA2	RPA2	9089	-0.012	0.39	NO
302	CDKN1B	CDKN1B	CDKN1B	9103	-0.012	0.39	NO
303	SSNA1	SSNA1	SSNA1	9144	-0.013	0.39	NO
304	PSMB10	PSMB10	PSMB10	9206	-0.014	0.39	NO
305	TINF2	TINF2	TINF2	9237	-0.014	0.39	NO
306	RFWD2	RFWD2	RFWD2	9287	-0.015	0.39	NO
307	PSMB1	PSMB1	PSMB1	9317	-0.015	0.38	NO
308	ANAPC7	ANAPC7	ANAPC7	9353	-0.015	0.38	NO
309	CEP164	CEP164	CEP164	9366	-0.015	0.38	NO
310	CDC16	CDC16	CDC16	9441	-0.016	0.38	NO
311	CCNH	CCNH	CCNH	9461	-0.016	0.38	NO
312	POLA1	POLA1	POLA1	9488	-0.017	0.38	NO
313	NUP133	NUP133	NUP133	9516	-0.017	0.38	NO
314	GORASP1	GORASP1	GORASP1	9521	-0.017	0.38	NO
315	ANAPC4	ANAPC4	ANAPC4	9667	-0.019	0.37	NO
316	TP53	TP53	TP53	9714	-0.019	0.37	NO
317	POLD3	POLD3	POLD3	9730	-0.019	0.37	NO
318	PPP2R3B	PPP2R3B	PPP2R3B	9864	-0.021	0.36	NO
319	PSMD6	PSMD6	PSMD6	9911	-0.021	0.36	NO
320	DCTN2	DCTN2	DCTN2	9995	-0.022	0.36	NO
321	OFD1	OFD1	OFD1	10006	-0.022	0.36	NO
322	CEP57	CEP57	CEP57	10044	-0.023	0.35	NO
323	PMF1	PMF1	PMF1	10065	-0.023	0.35	NO
324	PPP1CC	PPP1CC	PPP1CC	10091	-0.023	0.35	NO
325	SMC1A	SMC1A	SMC1A	10363	-0.026	0.34	NO
326	PSMB6	PSMB6	PSMB6	10392	-0.026	0.34	NO
327	RB1	RB1	RB1	10458	-0.027	0.34	NO
328	RBL2	RBL2	RBL2	10469	-0.028	0.34	NO
329	ANAPC5	ANAPC5	ANAPC5	10493	-0.028	0.33	NO
330	GMNN	GMNN	GMNN	10506	-0.028	0.34	NO
331	LIN52	LIN52	LIN52	10507	-0.028	0.34	NO
332	CEP290	CEP290	CEP290	10516	-0.028	0.34	NO
333	RPA1	RPA1	RPA1	10536	-0.028	0.34	NO
334	MAX	MAX	MAX	10558	-0.029	0.34	NO
335	HIST2H2AC	HIST2H2AC	HIST2H2AC	10616	-0.03	0.33	NO
336	NUP43	NUP43	NUP43	10721	-0.031	0.33	NO
337	RANBP2	RANBP2	RANBP2	10769	-0.032	0.33	NO
338	TUBGCP3	TUBGCP3	TUBGCP3	11043	-0.036	0.31	NO
339	TUBGCP6	TUBGCP6	TUBGCP6	11074	-0.036	0.31	NO
340	CDKN2C	CDKN2C	CDKN2C	11098	-0.036	0.31	NO
341	TERF2	TERF2	TERF2	11185	-0.038	0.31	NO
342	HIST1H4C	HIST1H4C	HIST1H4C	11308	-0.04	0.3	NO
343	CDC26	CDC26	CDC26	11351	-0.04	0.3	NO
344	PRKACA	PRKACA	PRKACA	11373	-0.04	0.3	NO
345	AKAP9	AKAP9	AKAP9	11420	-0.041	0.3	NO
346	ANAPC2	ANAPC2	ANAPC2	11466	-0.042	0.3	NO
347	UBA52	UBA52	UBA52	11476	-0.042	0.3	NO
348	DYRK1A	DYRK1A	DYRK1A	11509	-0.043	0.3	NO
349	CENPC1	CENPC1	CENPC1	11513	-0.043	0.3	NO
350	TERF2IP	TERF2IP	TERF2IP	11591	-0.044	0.3	NO
351	RAD17	RAD17	RAD17	11596	-0.044	0.3	NO
352	ATM	ATM	ATM	11624	-0.045	0.3	NO
353	HIST1H2BH	HIST1H2BH	HIST1H2BH	11661	-0.045	0.3	NO
354	PPP2R1B	PPP2R1B	PPP2R1B	11667	-0.046	0.3	NO
355	APITD1	APITD1	APITD1	11910	-0.05	0.29	NO
356	CCND3	CCND3	CCND3	11961	-0.051	0.28	NO
357	DCTN3	DCTN3	DCTN3	12060	-0.052	0.28	NO
358	BTRC	BTRC	BTRC	12104	-0.053	0.28	NO
359	PCM1	PCM1	PCM1	12166	-0.054	0.28	NO
360	PAFAH1B1	PAFAH1B1	PAFAH1B1	12209	-0.055	0.28	NO
361	PCNT	PCNT	PCNT	12274	-0.057	0.28	NO
362	WRAP53	WRAP53	WRAP53	12445	-0.06	0.27	NO
363	PPP2R5A	PPP2R5A	PPP2R5A	13073	-0.074	0.24	NO
364	B9D2	B9D2	B9D2	13178	-0.077	0.23	NO
365	NSL1	NSL1	NSL1	13249	-0.079	0.23	NO
366	CDC14A	CDC14A	CDC14A	13905	-0.099	0.2	NO
367	MIS12	MIS12	MIS12	14114	-0.11	0.19	NO
368	RPA4	RPA4	RPA4	14716	-0.13	0.16	NO
369	RPS27	RPS27	RPS27	15001	-0.14	0.15	NO
370	CCNA1	CCNA1	CCNA1	15153	-0.15	0.14	NO
371	CCND2	CCND2	CCND2	15348	-0.16	0.14	NO
372	SYNE1	SYNE1	SYNE1	15352	-0.16	0.14	NO
373	STAG3	STAG3	STAG3	15363	-0.16	0.15	NO
374	PSMA8	PSMA8	PSMA8	16164	-0.22	0.11	NO
375	PRKAR2B	PRKAR2B	PRKAR2B	16712	-0.26	0.088	NO
376	REC8	REC8	REC8	17109	-0.3	0.075	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	IL8	IL8	IL8	730	0.24	0.04	YES
2	LAMA3	LAMA3	LAMA3	797	0.23	0.11	YES
3	FN1	FN1	FN1	841	0.22	0.19	YES
4	EPHB2	EPHB2	EPHB2	1034	0.2	0.24	YES
5	LAMA1	LAMA1	LAMA1	1036	0.2	0.31	YES
6	ITGA2	ITGA2	ITGA2	1085	0.19	0.37	YES
7	CAV2	CAV2	CAV2	1377	0.16	0.41	YES
8	CSF2	CSF2	CSF2	1392	0.16	0.46	YES
9	MMP2	MMP2	MMP2	1406	0.16	0.52	YES
10	ITGA5	ITGA5	ITGA5	1466	0.16	0.57	YES
11	RASA1	RASA1	RASA1	2308	0.1	0.56	YES
12	EZR	EZR	EZR	2420	0.097	0.58	YES
13	ITGB1	ITGB1	ITGB1	2633	0.089	0.6	YES
14	TGFB1	TGFB1	TGFB1	2669	0.087	0.63	YES
15	SRC	SRC	SRC	4208	0.048	0.56	NO
16	HRAS	HRAS	HRAS	4413	0.045	0.56	NO
17	MAPK8	MAPK8	MAPK8	5036	0.035	0.54	NO
18	NF1	NF1	NF1	5659	0.026	0.52	NO
19	RHOA	RHOA	RHOA	5695	0.026	0.52	NO
20	CASK	CASK	CASK	5952	0.022	0.52	NO
21	KNG1	KNG1	KNG1	6407	0.017	0.5	NO
22	MAPK3	MAPK3	MAPK3	7034	0.011	0.47	NO
23	CASP3	CASP3	CASP3	7174	0.009	0.46	NO
24	BAX	BAX	BAX	7713	0.0028	0.44	NO
25	MAPK1	MAPK1	MAPK1	8193	-0.0023	0.41	NO
26	SDCBP	SDCBP	SDCBP	8262	-0.0031	0.41	NO
27	GNB2L1	GNB2L1	GNB2L1	8862	-0.0097	0.38	NO
28	SDC2	SDC2	SDC2	10818	-0.032	0.28	NO
29	PRKCD	PRKCD	PRKCD	10892	-0.034	0.29	NO
30	PRKACA	PRKACA	PRKACA	11373	-0.04	0.28	NO
31	TRAPPC4	TRAPPC4	TRAPPC4	11782	-0.048	0.27	NO
32	EPB41	EPB41	EPB41	13870	-0.098	0.19	NO
33	TNFRSF13B	TNFRSF13B	TNFRSF13B	15544	-0.18	0.16	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TP73	TP73	TP73	54	0.5	0.062	YES
2	SERPINB5	SERPINB5	SERPINB5	281	0.34	0.094	YES
3	CCNB2	CCNB2	CCNB2	440	0.3	0.12	YES
4	SFN	SFN	SFN	450	0.29	0.16	YES
5	TP53AIP1	TP53AIP1	TP53AIP1	484	0.28	0.2	YES
6	PMAIP1	PMAIP1	PMAIP1	524	0.28	0.23	YES
7	GTSE1	GTSE1	GTSE1	752	0.24	0.25	YES
8	CDK1	CDK1	CDK1	888	0.22	0.27	YES
9	CCNE1	CCNE1	CCNE1	930	0.22	0.29	YES
10	STEAP3	STEAP3	STEAP3	989	0.21	0.32	YES
11	RRM2	RRM2	RRM2	1040	0.2	0.34	YES
12	CCNE2	CCNE2	CCNE2	1067	0.2	0.36	YES
13	CCNB1	CCNB1	CCNB1	1102	0.19	0.39	YES
14	IGFBP3	IGFBP3	IGFBP3	1206	0.18	0.41	YES
15	CHEK1	CHEK1	CHEK1	1292	0.17	0.42	YES
16	SERPINE1	SERPINE1	SERPINE1	1486	0.16	0.43	YES
17	CCND1	CCND1	CCND1	1526	0.15	0.45	YES
18	TNFRSF10B	TNFRSF10B	TNFRSF10B	1869	0.13	0.45	YES
19	PERP	PERP	PERP	1900	0.12	0.46	YES
20	CCNG2	CCNG2	CCNG2	2013	0.12	0.47	YES
21	CDK6	CDK6	CDK6	2115	0.11	0.48	YES
22	BBC3	BBC3	BBC3	2198	0.11	0.49	YES
23	THBS1	THBS1	THBS1	2218	0.11	0.5	YES
24	CDK2	CDK2	CDK2	2260	0.11	0.52	YES
25	BID	BID	BID	2271	0.1	0.53	YES
26	CASP8	CASP8	CASP8	2423	0.097	0.53	YES
27	CD82	CD82	CD82	2646	0.088	0.53	YES
28	CHEK2	CHEK2	CHEK2	2710	0.086	0.54	YES
29	TP53I3	TP53I3	TP53I3	3794	0.057	0.49	NO
30	ATR	ATR	ATR	4674	0.04	0.45	NO
31	SIAH1	SIAH1	SIAH1	4688	0.04	0.45	NO
32	MDM2	MDM2	MDM2	4867	0.037	0.44	NO
33	EI24	EI24	EI24	5445	0.029	0.42	NO
34	SHISA5	SHISA5	SHISA5	5744	0.025	0.4	NO
35	DDB2	DDB2	DDB2	5915	0.023	0.4	NO
36	CDK4	CDK4	CDK4	5928	0.023	0.4	NO
37	CDKN1A	CDKN1A	CDKN1A	6056	0.021	0.4	NO
38	CDKN2A	CDKN2A	CDKN2A	6115	0.021	0.4	NO
39	GADD45A	GADD45A	GADD45A	6614	0.015	0.37	NO
40	CASP3	CASP3	CASP3	7174	0.009	0.34	NO
41	BAX	BAX	BAX	7713	0.0028	0.31	NO
42	ZMAT3	ZMAT3	ZMAT3	7967	-0.000038	0.3	NO
43	FAS	FAS	FAS	8537	-0.0062	0.27	NO
44	GADD45B	GADD45B	GADD45B	8631	-0.0072	0.26	NO
45	TSC2	TSC2	TSC2	8937	-0.011	0.25	NO
46	CYCS	CYCS	CYCS	9285	-0.015	0.23	NO
47	RFWD2	RFWD2	RFWD2	9287	-0.015	0.23	NO
48	RRM2B	RRM2B	RRM2B	9396	-0.016	0.23	NO
49	TP53	TP53	TP53	9714	-0.019	0.22	NO
50	PTEN	PTEN	PTEN	9804	-0.02	0.21	NO
51	BAI1	BAI1	BAI1	9851	-0.02	0.21	NO
52	CASP9	CASP9	CASP9	10248	-0.025	0.2	NO
53	RCHY1	RCHY1	RCHY1	11436	-0.042	0.14	NO
54	ATM	ATM	ATM	11624	-0.045	0.13	NO
55	SESN3	SESN3	SESN3	11947	-0.05	0.12	NO
56	CCND3	CCND3	CCND3	11961	-0.051	0.13	NO
57	MDM4	MDM4	MDM4	12605	-0.063	0.1	NO
58	CCNG1	CCNG1	CCNG1	13254	-0.079	0.075	NO
59	APAF1	APAF1	APAF1	13974	-0.1	0.049	NO
60	SESN2	SESN2	SESN2	14505	-0.12	0.036	NO
61	PPM1D	PPM1D	PPM1D	14671	-0.13	0.044	NO
62	CCND2	CCND2	CCND2	15348	-0.16	0.028	NO
63	CCNB3	CCNB3	CCNB3	15614	-0.18	0.037	NO
64	IGF1	IGF1	IGF1	15695	-0.18	0.057	NO
65	RPRM	RPRM	RPRM	15727	-0.19	0.079	NO
66	SESN1	SESN1	SESN1	16201	-0.22	0.082	NO
67	GADD45G	GADD45G	GADD45G	17256	-0.32	0.065	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	KIF18A	KIF18A	KIF18A	148	0.41	0.0084	YES
2	SPC24	SPC24	SPC24	165	0.4	0.024	YES
3	CDC25C	CDC25C	CDC25C	214	0.37	0.036	YES
4	BIRC5	BIRC5	BIRC5	220	0.37	0.05	YES
5	MCM10	MCM10	MCM10	250	0.35	0.063	YES
6	CENPA	CENPA	CENPA	263	0.35	0.076	YES
7	CENPI	CENPI	CENPI	269	0.34	0.09	YES
8	NEK2	NEK2	NEK2	278	0.34	0.1	YES
9	KIF20A	KIF20A	KIF20A	300	0.34	0.12	YES
10	UBE2C	UBE2C	UBE2C	333	0.32	0.13	YES
11	SGOL1	SGOL1	SGOL1	335	0.32	0.14	YES
12	PKMYT1	PKMYT1	PKMYT1	350	0.32	0.15	YES
13	KIF23	KIF23	KIF23	354	0.32	0.16	YES
14	CDC45	CDC45	CDC45	373	0.31	0.18	YES
15	CDC20	CDC20	CDC20	395	0.3	0.19	YES
16	KIF2C	KIF2C	KIF2C	401	0.3	0.2	YES
17	ERCC6L	ERCC6L	ERCC6L	407	0.3	0.21	YES
18	BUB1	BUB1	BUB1	416	0.3	0.22	YES
19	CCNB2	CCNB2	CCNB2	440	0.3	0.23	YES
20	CENPK	CENPK	CENPK	449	0.29	0.24	YES
21	PLK4	PLK4	PLK4	542	0.27	0.25	YES
22	CASC5	CASC5	CASC5	584	0.27	0.26	YES
23	BUB1B	BUB1B	BUB1B	608	0.26	0.27	YES
24	AURKB	AURKB	AURKB	625	0.26	0.28	YES
25	MYBL2	MYBL2	MYBL2	632	0.26	0.29	YES
26	E2F1	E2F1	E2F1	659	0.25	0.3	YES
27	NUF2	NUF2	NUF2	664	0.25	0.31	YES
28	PLK1	PLK1	PLK1	672	0.25	0.32	YES
29	CDC6	CDC6	CDC6	762	0.24	0.32	YES
30	CDT1	CDT1	CDT1	771	0.23	0.33	YES
31	POLE2	POLE2	POLE2	857	0.22	0.33	YES
32	GINS4	GINS4	GINS4	875	0.22	0.34	YES
33	AURKA	AURKA	AURKA	877	0.22	0.35	YES
34	PTTG1	PTTG1	PTTG1	884	0.22	0.36	YES
35	CDK1	CDK1	CDK1	888	0.22	0.37	YES
36	CCNE1	CCNE1	CCNE1	930	0.22	0.37	YES
37	CCNA2	CCNA2	CCNA2	939	0.21	0.38	YES
38	NDC80	NDC80	NDC80	979	0.21	0.39	YES
39	SKA1	SKA1	SKA1	993	0.21	0.4	YES
40	MCM2	MCM2	MCM2	1030	0.2	0.4	YES
41	RRM2	RRM2	RRM2	1040	0.2	0.41	YES
42	CCNE2	CCNE2	CCNE2	1067	0.2	0.42	YES
43	GINS2	GINS2	GINS2	1087	0.19	0.42	YES
44	MCM4	MCM4	MCM4	1089	0.19	0.43	YES
45	MAD2L1	MAD2L1	MAD2L1	1091	0.19	0.44	YES
46	CCNB1	CCNB1	CCNB1	1102	0.19	0.45	YES
47	GINS1	GINS1	GINS1	1126	0.19	0.45	YES
48	CDCA8	CDCA8	CDCA8	1135	0.19	0.46	YES
49	CENPM	CENPM	CENPM	1250	0.18	0.46	YES
50	KNTC1	KNTC1	KNTC1	1299	0.17	0.46	YES
51	SGOL2	SGOL2	SGOL2	1338	0.17	0.47	YES
52	RFC4	RFC4	RFC4	1365	0.17	0.48	YES
53	MLF1IP	MLF1IP	MLF1IP	1380	0.16	0.48	YES
54	CENPH	CENPH	CENPH	1442	0.16	0.48	YES
55	CCND1	CCND1	CCND1	1526	0.15	0.48	YES
56	ZWINT	ZWINT	ZWINT	1606	0.15	0.49	YES
57	CKS1B	CKS1B	CKS1B	1615	0.14	0.49	YES
58	TYMS	TYMS	TYMS	1647	0.14	0.5	YES
59	SPC25	SPC25	SPC25	1784	0.13	0.49	YES
60	DNA2	DNA2	DNA2	2018	0.12	0.49	YES
61	CDC25A	CDC25A	CDC25A	2038	0.12	0.49	YES
62	INCENP	INCENP	INCENP	2105	0.11	0.49	YES
63	WEE1	WEE1	WEE1	2106	0.11	0.5	YES
64	CDK6	CDK6	CDK6	2115	0.11	0.5	YES
65	CCDC99	CCDC99	CCDC99	2153	0.11	0.5	YES
66	CENPN	CENPN	CENPN	2235	0.11	0.5	YES
67	CDK2	CDK2	CDK2	2260	0.11	0.5	YES
68	E2F2	E2F2	E2F2	2298	0.1	0.51	YES
69	ZWILCH	ZWILCH	ZWILCH	2371	0.1	0.51	YES
70	MNAT1	MNAT1	MNAT1	2403	0.098	0.51	YES
71	CENPO	CENPO	CENPO	2424	0.097	0.51	YES
72	TUBA4A	TUBA4A	TUBA4A	2427	0.097	0.52	YES
73	RFC2	RFC2	RFC2	2435	0.097	0.52	YES
74	POLD1	POLD1	POLD1	2510	0.094	0.52	YES
75	NUP107	NUP107	NUP107	2554	0.092	0.52	YES
76	LIN9	LIN9	LIN9	2577	0.09	0.52	YES
77	E2F3	E2F3	E2F3	2606	0.09	0.52	YES
78	PSMD2	PSMD2	PSMD2	2609	0.089	0.53	YES
79	RBL1	RBL1	RBL1	2663	0.087	0.53	YES
80	CSNK1E	CSNK1E	CSNK1E	2670	0.087	0.53	YES
81	MCM7	MCM7	MCM7	2678	0.087	0.54	YES
82	CDC7	CDC7	CDC7	2696	0.086	0.54	YES
83	RCC2	RCC2	RCC2	2753	0.084	0.54	YES
84	AZI1	AZI1	AZI1	2760	0.084	0.54	YES
85	FEN1	FEN1	FEN1	2771	0.084	0.54	YES
86	CENPJ	CENPJ	CENPJ	2823	0.082	0.54	YES
87	DSN1	DSN1	DSN1	2848	0.082	0.55	YES
88	PSMD14	PSMD14	PSMD14	2871	0.081	0.55	YES
89	MCM6	MCM6	MCM6	2932	0.079	0.55	YES
90	CDKN2B	CDKN2B	CDKN2B	2966	0.078	0.55	YES
91	NUP85	NUP85	NUP85	3129	0.073	0.54	YES
92	PRIM2	PRIM2	PRIM2	3200	0.071	0.54	YES
93	MCM8	MCM8	MCM8	3214	0.071	0.55	YES
94	CENPL	CENPL	CENPL	3241	0.07	0.55	YES
95	CENPP	CENPP	CENPP	3309	0.068	0.55	YES
96	PSMD12	PSMD12	PSMD12	3311	0.068	0.55	YES
97	TUBB	TUBB	TUBB	3374	0.067	0.55	YES
98	CDKN2D	CDKN2D	CDKN2D	3379	0.067	0.55	YES
99	RPA3	RPA3	RPA3	3390	0.067	0.55	YES
100	MCM5	MCM5	MCM5	3395	0.067	0.55	YES
101	CKAP5	CKAP5	CKAP5	3467	0.065	0.55	YES
102	SKP2	SKP2	SKP2	3471	0.065	0.56	YES
103	RANGAP1	RANGAP1	RANGAP1	3562	0.062	0.55	YES
104	RFC5	RFC5	RFC5	3577	0.062	0.56	YES
105	PPP2R2A	PPP2R2A	PPP2R2A	3596	0.061	0.56	YES
106	CDK7	CDK7	CDK7	3599	0.061	0.56	YES
107	PSMD7	PSMD7	PSMD7	3660	0.06	0.56	YES
108	UBE2E1	UBE2E1	UBE2E1	3695	0.059	0.56	YES
109	PSMD11	PSMD11	PSMD11	3713	0.058	0.56	YES
110	TAOK1	TAOK1	TAOK1	3723	0.058	0.56	YES
111	NUP37	NUP37	NUP37	3731	0.058	0.56	YES
112	LIG1	LIG1	LIG1	3804	0.056	0.56	NO
113	XPO1	XPO1	XPO1	3930	0.054	0.56	NO
114	DYNC1I2	DYNC1I2	DYNC1I2	4015	0.052	0.55	NO
115	PSMA1	PSMA1	PSMA1	4051	0.051	0.55	NO
116	ZW10	ZW10	ZW10	4053	0.051	0.56	NO
117	ANAPC11	ANAPC11	ANAPC11	4073	0.051	0.56	NO
118	YWHAG	YWHAG	YWHAG	4091	0.05	0.56	NO
119	TUBG1	TUBG1	TUBG1	4092	0.05	0.56	NO
120	HSP90AA1	HSP90AA1	HSP90AA1	4138	0.05	0.56	NO
121	POLD4	POLD4	POLD4	4167	0.049	0.56	NO
122	PCNA	PCNA	PCNA	4202	0.048	0.56	NO
123	TK2	TK2	TK2	4225	0.048	0.56	NO
124	PSMB2	PSMB2	PSMB2	4258	0.047	0.56	NO
125	PSMA7	PSMA7	PSMA7	4327	0.046	0.56	NO
126	DBF4	DBF4	DBF4	4330	0.046	0.56	NO
127	RFC3	RFC3	RFC3	4368	0.045	0.56	NO
128	ANAPC1	ANAPC1	ANAPC1	4384	0.045	0.56	NO
129	PSMA5	PSMA5	PSMA5	4401	0.045	0.56	NO
130	CENPQ	CENPQ	CENPQ	4447	0.044	0.56	NO
131	LIN37	LIN37	LIN37	4497	0.043	0.56	NO
132	RAD21	RAD21	RAD21	4525	0.043	0.56	NO
133	PSMA6	PSMA6	PSMA6	4582	0.042	0.56	NO
134	NUMA1	NUMA1	NUMA1	4615	0.041	0.56	NO
135	UBE2D1	UBE2D1	UBE2D1	4616	0.041	0.56	NO
136	MAD1L1	MAD1L1	MAD1L1	4667	0.04	0.56	NO
137	CLIP1	CLIP1	CLIP1	4673	0.04	0.56	NO
138	PPP2R5E	PPP2R5E	PPP2R5E	4701	0.04	0.56	NO
139	POLA2	POLA2	POLA2	4740	0.039	0.56	NO
140	PSMD8	PSMD8	PSMD8	4821	0.038	0.56	NO
141	STAG1	STAG1	STAG1	4835	0.038	0.56	NO
142	NEDD1	NEDD1	NEDD1	4879	0.037	0.56	NO
143	ITGB3BP	ITGB3BP	ITGB3BP	4881	0.037	0.56	NO
144	CETN2	CETN2	CETN2	4960	0.036	0.56	NO
145	CEP250	CEP250	CEP250	5045	0.035	0.55	NO
146	PSMD13	PSMD13	PSMD13	5082	0.034	0.55	NO
147	POLE	POLE	POLE	5120	0.034	0.55	NO
148	CEP70	CEP70	CEP70	5156	0.033	0.55	NO
149	CEP72	CEP72	CEP72	5180	0.033	0.55	NO
150	PSMC3	PSMC3	PSMC3	5187	0.033	0.55	NO
151	BUB3	BUB3	BUB3	5218	0.032	0.55	NO
152	PSMC1	PSMC1	PSMC1	5255	0.032	0.55	NO
153	PSMD1	PSMD1	PSMD1	5280	0.032	0.55	NO
154	PSMC6	PSMC6	PSMC6	5442	0.029	0.54	NO
155	HAUS2	HAUS2	HAUS2	5457	0.029	0.55	NO
156	CDC23	CDC23	CDC23	5505	0.028	0.54	NO
157	KIF2A	KIF2A	KIF2A	5545	0.028	0.54	NO
158	PSMD5	PSMD5	PSMD5	5561	0.028	0.54	NO
159	PSME4	PSME4	PSME4	5630	0.027	0.54	NO
160	ANAPC10	ANAPC10	ANAPC10	5665	0.026	0.54	NO
161	PSMC4	PSMC4	PSMC4	5669	0.026	0.54	NO
162	DHFR	DHFR	DHFR	5672	0.026	0.54	NO
163	TFDP1	TFDP1	TFDP1	5771	0.025	0.54	NO
164	PSMA3	PSMA3	PSMA3	5831	0.024	0.53	NO
165	PSMD4	PSMD4	PSMD4	5878	0.024	0.53	NO
166	CENPT	CENPT	CENPT	5884	0.023	0.53	NO
167	CDK4	CDK4	CDK4	5928	0.023	0.53	NO
168	CDC25B	CDC25B	CDC25B	6043	0.021	0.53	NO
169	PSMD10	PSMD10	PSMD10	6055	0.021	0.53	NO
170	CDKN1A	CDKN1A	CDKN1A	6056	0.021	0.53	NO
171	SKA2	SKA2	SKA2	6077	0.021	0.53	NO
172	CDKN2A	CDKN2A	CDKN2A	6115	0.021	0.53	NO
173	SEC13	SEC13	SEC13	6170	0.02	0.52	NO
174	PPP2R5B	PPP2R5B	PPP2R5B	6173	0.02	0.52	NO
175	DYNC1H1	DYNC1H1	DYNC1H1	6188	0.02	0.52	NO
176	PSMD3	PSMD3	PSMD3	6194	0.02	0.52	NO
177	NUDC	NUDC	NUDC	6225	0.019	0.52	NO
178	CDC27	CDC27	CDC27	6249	0.019	0.52	NO
179	PSMA2	PSMA2	PSMA2	6271	0.019	0.52	NO
180	PSMA4	PSMA4	PSMA4	6379	0.018	0.52	NO
181	PSMB5	PSMB5	PSMB5	6385	0.018	0.52	NO
182	PSMB3	PSMB3	PSMB3	6437	0.017	0.52	NO
183	NDEL1	NDEL1	NDEL1	6654	0.014	0.5	NO
184	CLASP1	CLASP1	CLASP1	6661	0.014	0.5	NO
185	HDAC1	HDAC1	HDAC1	6671	0.014	0.5	NO
186	PSMB9	PSMB9	PSMB9	6695	0.014	0.5	NO
187	E2F4	E2F4	E2F4	6720	0.014	0.5	NO
188	PPP2R1A	PPP2R1A	PPP2R1A	6745	0.014	0.5	NO
189	PPP2CA	PPP2CA	PPP2CA	6752	0.014	0.5	NO
190	PSMB7	PSMB7	PSMB7	6763	0.013	0.5	NO
191	SEH1L	SEH1L	SEH1L	6823	0.013	0.5	NO
192	DYNLL1	DYNLL1	DYNLL1	6847	0.012	0.5	NO
193	PSMB4	PSMB4	PSMB4	6883	0.012	0.5	NO
194	MAPRE1	MAPRE1	MAPRE1	6962	0.011	0.5	NO
195	FGFR1OP	FGFR1OP	FGFR1OP	6971	0.011	0.5	NO
196	POLD2	POLD2	POLD2	7077	0.01	0.49	NO
197	RBBP4	RBBP4	RBBP4	7143	0.0094	0.49	NO
198	PSMD9	PSMD9	PSMD9	7162	0.0092	0.48	NO
199	MYC	MYC	MYC	7176	0.009	0.48	NO
200	PSMC2	PSMC2	PSMC2	7201	0.0088	0.48	NO
201	DCTN1	DCTN1	DCTN1	7237	0.0084	0.48	NO
202	CEP63	CEP63	CEP63	7355	0.0071	0.48	NO
203	PSMB8	PSMB8	PSMB8	7411	0.0065	0.47	NO
204	CEP135	CEP135	CEP135	7416	0.0064	0.47	NO
205	PSMC5	PSMC5	PSMC5	7439	0.0062	0.47	NO
206	TUBA1A	TUBA1A	TUBA1A	7597	0.0042	0.46	NO
207	PRIM1	PRIM1	PRIM1	7684	0.0032	0.46	NO
208	PPP2CB	PPP2CB	PPP2CB	7803	0.0017	0.45	NO
209	CEP192	CEP192	CEP192	7810	0.0016	0.45	NO
210	CSNK1D	CSNK1D	CSNK1D	7864	0.001	0.45	NO
211	MCM3	MCM3	MCM3	8011	-0.00046	0.44	NO
212	TUBGCP2	TUBGCP2	TUBGCP2	8056	-0.00092	0.44	NO
213	PPP2R5C	PPP2R5C	PPP2R5C	8066	-0.00098	0.44	NO
214	PSME2	PSME2	PSME2	8112	-0.0015	0.44	NO
215	ALMS1	ALMS1	ALMS1	8154	-0.0019	0.44	NO
216	LIN54	LIN54	LIN54	8197	-0.0024	0.43	NO
217	AHCTF1	AHCTF1	AHCTF1	8198	-0.0024	0.43	NO
218	PSMF1	PSMF1	PSMF1	8251	-0.003	0.43	NO
219	SKP1	SKP1	SKP1	8277	-0.0034	0.43	NO
220	TUBGCP5	TUBGCP5	TUBGCP5	8299	-0.0037	0.43	NO
221	YWHAE	YWHAE	YWHAE	8418	-0.005	0.42	NO
222	PSME1	PSME1	PSME1	8420	-0.005	0.42	NO
223	CDK5RAP2	CDK5RAP2	CDK5RAP2	8452	-0.0054	0.42	NO
224	NINL	NINL	NINL	8485	-0.0057	0.42	NO
225	E2F5	E2F5	E2F5	8487	-0.0058	0.42	NO
226	SDCCAG8	SDCCAG8	SDCCAG8	8760	-0.0086	0.4	NO
227	TUBG2	TUBG2	TUBG2	8762	-0.0086	0.4	NO
228	ACTR1A	ACTR1A	ACTR1A	8781	-0.0088	0.4	NO
229	FBXO5	FBXO5	FBXO5	8887	-0.01	0.4	NO
230	SMC3	SMC3	SMC3	8889	-0.01	0.4	NO
231	STAG2	STAG2	STAG2	8921	-0.01	0.4	NO
232	RPS27A	RPS27A	RPS27A	8932	-0.01	0.4	NO
233	CEP76	CEP76	CEP76	8956	-0.011	0.4	NO
234	PPP2R5D	PPP2R5D	PPP2R5D	8989	-0.011	0.4	NO
235	CUL1	CUL1	CUL1	9026	-0.012	0.39	NO
236	RPA2	RPA2	RPA2	9089	-0.012	0.39	NO
237	CDKN1B	CDKN1B	CDKN1B	9103	-0.012	0.39	NO
238	SSNA1	SSNA1	SSNA1	9144	-0.013	0.39	NO
239	PSMB10	PSMB10	PSMB10	9206	-0.014	0.39	NO
240	PSMB1	PSMB1	PSMB1	9317	-0.015	0.38	NO
241	ANAPC7	ANAPC7	ANAPC7	9353	-0.015	0.38	NO
242	CEP164	CEP164	CEP164	9366	-0.015	0.38	NO
243	CDC16	CDC16	CDC16	9441	-0.016	0.38	NO
244	CCNH	CCNH	CCNH	9461	-0.016	0.38	NO
245	POLA1	POLA1	POLA1	9488	-0.017	0.37	NO
246	NUP133	NUP133	NUP133	9516	-0.017	0.37	NO
247	GORASP1	GORASP1	GORASP1	9521	-0.017	0.37	NO
248	ANAPC4	ANAPC4	ANAPC4	9667	-0.019	0.37	NO
249	POLD3	POLD3	POLD3	9730	-0.019	0.36	NO
250	PPP2R3B	PPP2R3B	PPP2R3B	9864	-0.021	0.36	NO
251	PSMD6	PSMD6	PSMD6	9911	-0.021	0.36	NO
252	DCTN2	DCTN2	DCTN2	9995	-0.022	0.35	NO
253	OFD1	OFD1	OFD1	10006	-0.022	0.35	NO
254	CEP57	CEP57	CEP57	10044	-0.023	0.35	NO
255	PMF1	PMF1	PMF1	10065	-0.023	0.35	NO
256	PPP1CC	PPP1CC	PPP1CC	10091	-0.023	0.35	NO
257	SMC1A	SMC1A	SMC1A	10363	-0.026	0.34	NO
258	PSMB6	PSMB6	PSMB6	10392	-0.026	0.34	NO
259	RB1	RB1	RB1	10458	-0.027	0.33	NO
260	RBL2	RBL2	RBL2	10469	-0.028	0.34	NO
261	ANAPC5	ANAPC5	ANAPC5	10493	-0.028	0.34	NO
262	GMNN	GMNN	GMNN	10506	-0.028	0.34	NO
263	LIN52	LIN52	LIN52	10507	-0.028	0.34	NO
264	CEP290	CEP290	CEP290	10516	-0.028	0.34	NO
265	RPA1	RPA1	RPA1	10536	-0.028	0.34	NO
266	MAX	MAX	MAX	10558	-0.029	0.34	NO
267	NUP43	NUP43	NUP43	10721	-0.031	0.33	NO
268	RANBP2	RANBP2	RANBP2	10769	-0.032	0.33	NO
269	TUBGCP3	TUBGCP3	TUBGCP3	11043	-0.036	0.31	NO
270	TUBGCP6	TUBGCP6	TUBGCP6	11074	-0.036	0.31	NO
271	CDKN2C	CDKN2C	CDKN2C	11098	-0.036	0.31	NO
272	CDC26	CDC26	CDC26	11351	-0.04	0.3	NO
273	PRKACA	PRKACA	PRKACA	11373	-0.04	0.3	NO
274	AKAP9	AKAP9	AKAP9	11420	-0.041	0.3	NO
275	ANAPC2	ANAPC2	ANAPC2	11466	-0.042	0.3	NO
276	UBA52	UBA52	UBA52	11476	-0.042	0.3	NO
277	DYRK1A	DYRK1A	DYRK1A	11509	-0.043	0.3	NO
278	CENPC1	CENPC1	CENPC1	11513	-0.043	0.3	NO
279	PPP2R1B	PPP2R1B	PPP2R1B	11667	-0.046	0.3	NO
280	APITD1	APITD1	APITD1	11910	-0.05	0.29	NO
281	CCND3	CCND3	CCND3	11961	-0.051	0.28	NO
282	DCTN3	DCTN3	DCTN3	12060	-0.052	0.28	NO
283	BTRC	BTRC	BTRC	12104	-0.053	0.28	NO
284	PCM1	PCM1	PCM1	12166	-0.054	0.28	NO
285	PAFAH1B1	PAFAH1B1	PAFAH1B1	12209	-0.055	0.28	NO
286	PCNT	PCNT	PCNT	12274	-0.057	0.28	NO
287	PPP2R5A	PPP2R5A	PPP2R5A	13073	-0.074	0.24	NO
288	B9D2	B9D2	B9D2	13178	-0.077	0.24	NO
289	NSL1	NSL1	NSL1	13249	-0.079	0.24	NO
290	CDC14A	CDC14A	CDC14A	13905	-0.099	0.2	NO
291	MIS12	MIS12	MIS12	14114	-0.11	0.2	NO
292	RPA4	RPA4	RPA4	14716	-0.13	0.17	NO
293	RPS27	RPS27	RPS27	15001	-0.14	0.16	NO
294	CCNA1	CCNA1	CCNA1	15153	-0.15	0.16	NO
295	CCND2	CCND2	CCND2	15348	-0.16	0.15	NO
296	PSMA8	PSMA8	PSMA8	16164	-0.22	0.12	NO
297	PRKAR2B	PRKAR2B	PRKAR2B	16712	-0.26	0.096	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NEK2	NEK2	NEK2	278	0.34	0.094	YES
2	PLK4	PLK4	PLK4	542	0.27	0.17	YES
3	PLK1	PLK1	PLK1	672	0.25	0.24	YES
4	CDK1	CDK1	CDK1	888	0.22	0.3	YES
5	CCNB1	CCNB1	CCNB1	1102	0.19	0.35	YES
6	TUBA4A	TUBA4A	TUBA4A	2427	0.097	0.31	YES
7	CSNK1E	CSNK1E	CSNK1E	2670	0.087	0.32	YES
8	AZI1	AZI1	AZI1	2760	0.084	0.34	YES
9	CENPJ	CENPJ	CENPJ	2823	0.082	0.37	YES
10	TUBB	TUBB	TUBB	3374	0.067	0.36	YES
11	CKAP5	CKAP5	CKAP5	3467	0.065	0.37	YES
12	DYNC1I2	DYNC1I2	DYNC1I2	4015	0.052	0.36	YES
13	YWHAG	YWHAG	YWHAG	4091	0.05	0.37	YES
14	TUBG1	TUBG1	TUBG1	4092	0.05	0.39	YES
15	HSP90AA1	HSP90AA1	HSP90AA1	4138	0.05	0.4	YES
16	NUMA1	NUMA1	NUMA1	4615	0.041	0.39	YES
17	NEDD1	NEDD1	NEDD1	4879	0.037	0.39	YES
18	CETN2	CETN2	CETN2	4960	0.036	0.39	YES
19	CEP250	CEP250	CEP250	5045	0.035	0.4	YES
20	CEP70	CEP70	CEP70	5156	0.033	0.4	YES
21	CEP72	CEP72	CEP72	5180	0.033	0.41	YES
22	HAUS2	HAUS2	HAUS2	5457	0.029	0.41	NO
23	DYNC1H1	DYNC1H1	DYNC1H1	6188	0.02	0.37	NO
24	CLASP1	CLASP1	CLASP1	6661	0.014	0.35	NO
25	PPP2R1A	PPP2R1A	PPP2R1A	6745	0.014	0.35	NO
26	DYNLL1	DYNLL1	DYNLL1	6847	0.012	0.35	NO
27	MAPRE1	MAPRE1	MAPRE1	6962	0.011	0.35	NO
28	FGFR1OP	FGFR1OP	FGFR1OP	6971	0.011	0.35	NO
29	DCTN1	DCTN1	DCTN1	7237	0.0084	0.34	NO
30	CEP63	CEP63	CEP63	7355	0.0071	0.34	NO
31	CEP135	CEP135	CEP135	7416	0.0064	0.34	NO
32	TUBA1A	TUBA1A	TUBA1A	7597	0.0042	0.33	NO
33	CEP192	CEP192	CEP192	7810	0.0016	0.32	NO
34	CSNK1D	CSNK1D	CSNK1D	7864	0.001	0.31	NO
35	TUBGCP2	TUBGCP2	TUBGCP2	8056	-0.00092	0.3	NO
36	ALMS1	ALMS1	ALMS1	8154	-0.0019	0.3	NO
37	TUBGCP5	TUBGCP5	TUBGCP5	8299	-0.0037	0.29	NO
38	YWHAE	YWHAE	YWHAE	8418	-0.005	0.29	NO
39	CDK5RAP2	CDK5RAP2	CDK5RAP2	8452	-0.0054	0.29	NO
40	NINL	NINL	NINL	8485	-0.0057	0.29	NO
41	SDCCAG8	SDCCAG8	SDCCAG8	8760	-0.0086	0.28	NO
42	TUBG2	TUBG2	TUBG2	8762	-0.0086	0.28	NO
43	ACTR1A	ACTR1A	ACTR1A	8781	-0.0088	0.28	NO
44	CEP76	CEP76	CEP76	8956	-0.011	0.27	NO
45	SSNA1	SSNA1	SSNA1	9144	-0.013	0.27	NO
46	CEP164	CEP164	CEP164	9366	-0.015	0.26	NO
47	DCTN2	DCTN2	DCTN2	9995	-0.022	0.23	NO
48	OFD1	OFD1	OFD1	10006	-0.022	0.24	NO
49	CEP57	CEP57	CEP57	10044	-0.023	0.24	NO
50	CEP290	CEP290	CEP290	10516	-0.028	0.23	NO
51	TUBGCP3	TUBGCP3	TUBGCP3	11043	-0.036	0.21	NO
52	TUBGCP6	TUBGCP6	TUBGCP6	11074	-0.036	0.22	NO
53	PRKACA	PRKACA	PRKACA	11373	-0.04	0.22	NO
54	AKAP9	AKAP9	AKAP9	11420	-0.041	0.23	NO
55	DCTN3	DCTN3	DCTN3	12060	-0.052	0.21	NO
56	PCM1	PCM1	PCM1	12166	-0.054	0.22	NO
57	PAFAH1B1	PAFAH1B1	PAFAH1B1	12209	-0.055	0.24	NO
58	PCNT	PCNT	PCNT	12274	-0.057	0.25	NO
59	PRKAR2B	PRKAR2B	PRKAR2B	16712	-0.26	0.095	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MCM10	MCM10	MCM10	250	0.35	0.028	YES
2	PKMYT1	PKMYT1	PKMYT1	350	0.32	0.059	YES
3	CDC45	CDC45	CDC45	373	0.31	0.094	YES
4	MYBL2	MYBL2	MYBL2	632	0.26	0.11	YES
5	E2F1	E2F1	E2F1	659	0.25	0.14	YES
6	CDC6	CDC6	CDC6	762	0.24	0.16	YES
7	CDT1	CDT1	CDT1	771	0.23	0.19	YES
8	POLE2	POLE2	POLE2	857	0.22	0.21	YES
9	CDK1	CDK1	CDK1	888	0.22	0.23	YES
10	CCNE1	CCNE1	CCNE1	930	0.22	0.26	YES
11	CCNA2	CCNA2	CCNA2	939	0.21	0.28	YES
12	MCM2	MCM2	MCM2	1030	0.2	0.3	YES
13	RRM2	RRM2	RRM2	1040	0.2	0.32	YES
14	CCNE2	CCNE2	CCNE2	1067	0.2	0.34	YES
15	MCM4	MCM4	MCM4	1089	0.19	0.36	YES
16	CCNB1	CCNB1	CCNB1	1102	0.19	0.39	YES
17	CCND1	CCND1	CCND1	1526	0.15	0.38	YES
18	CKS1B	CKS1B	CKS1B	1615	0.14	0.39	YES
19	TYMS	TYMS	TYMS	1647	0.14	0.41	YES
20	CDC25A	CDC25A	CDC25A	2038	0.12	0.4	YES
21	WEE1	WEE1	WEE1	2106	0.11	0.41	YES
22	CDK6	CDK6	CDK6	2115	0.11	0.42	YES
23	CDK2	CDK2	CDK2	2260	0.11	0.43	YES
24	E2F2	E2F2	E2F2	2298	0.1	0.44	YES
25	MNAT1	MNAT1	MNAT1	2403	0.098	0.44	YES
26	LIN9	LIN9	LIN9	2577	0.09	0.44	YES
27	E2F3	E2F3	E2F3	2606	0.09	0.45	YES
28	PSMD2	PSMD2	PSMD2	2609	0.089	0.46	YES
29	RBL1	RBL1	RBL1	2663	0.087	0.47	YES
30	MCM7	MCM7	MCM7	2678	0.087	0.48	YES
31	CDC7	CDC7	CDC7	2696	0.086	0.49	YES
32	PSMD14	PSMD14	PSMD14	2871	0.081	0.49	YES
33	MCM6	MCM6	MCM6	2932	0.079	0.5	YES
34	CDKN2B	CDKN2B	CDKN2B	2966	0.078	0.5	YES
35	PRIM2	PRIM2	PRIM2	3200	0.071	0.5	YES
36	MCM8	MCM8	MCM8	3214	0.071	0.5	YES
37	PSMD12	PSMD12	PSMD12	3311	0.068	0.51	YES
38	CDKN2D	CDKN2D	CDKN2D	3379	0.067	0.51	YES
39	RPA3	RPA3	RPA3	3390	0.067	0.52	YES
40	MCM5	MCM5	MCM5	3395	0.067	0.53	YES
41	SKP2	SKP2	SKP2	3471	0.065	0.53	YES
42	PPP2R2A	PPP2R2A	PPP2R2A	3596	0.061	0.53	YES
43	CDK7	CDK7	CDK7	3599	0.061	0.54	YES
44	PSMD7	PSMD7	PSMD7	3660	0.06	0.54	YES
45	PSMD11	PSMD11	PSMD11	3713	0.058	0.55	YES
46	PSMA1	PSMA1	PSMA1	4051	0.051	0.53	YES
47	PCNA	PCNA	PCNA	4202	0.048	0.53	YES
48	TK2	TK2	TK2	4225	0.048	0.54	YES
49	PSMB2	PSMB2	PSMB2	4258	0.047	0.54	YES
50	PSMA7	PSMA7	PSMA7	4327	0.046	0.54	YES
51	DBF4	DBF4	DBF4	4330	0.046	0.55	YES
52	PSMA5	PSMA5	PSMA5	4401	0.045	0.55	YES
53	LIN37	LIN37	LIN37	4497	0.043	0.55	YES
54	PSMA6	PSMA6	PSMA6	4582	0.042	0.55	YES
55	POLA2	POLA2	POLA2	4740	0.039	0.54	NO
56	PSMD8	PSMD8	PSMD8	4821	0.038	0.54	NO
57	PSMD13	PSMD13	PSMD13	5082	0.034	0.53	NO
58	POLE	POLE	POLE	5120	0.034	0.54	NO
59	PSMC3	PSMC3	PSMC3	5187	0.033	0.54	NO
60	PSMC1	PSMC1	PSMC1	5255	0.032	0.54	NO
61	PSMD1	PSMD1	PSMD1	5280	0.032	0.54	NO
62	PSMC6	PSMC6	PSMC6	5442	0.029	0.53	NO
63	PSMD5	PSMD5	PSMD5	5561	0.028	0.53	NO
64	PSMC4	PSMC4	PSMC4	5669	0.026	0.53	NO
65	DHFR	DHFR	DHFR	5672	0.026	0.53	NO
66	TFDP1	TFDP1	TFDP1	5771	0.025	0.53	NO
67	PSMA3	PSMA3	PSMA3	5831	0.024	0.53	NO
68	PSMD4	PSMD4	PSMD4	5878	0.024	0.53	NO
69	CDK4	CDK4	CDK4	5928	0.023	0.53	NO
70	PSMD10	PSMD10	PSMD10	6055	0.021	0.52	NO
71	CDKN1A	CDKN1A	CDKN1A	6056	0.021	0.52	NO
72	CDKN2A	CDKN2A	CDKN2A	6115	0.021	0.52	NO
73	PSMD3	PSMD3	PSMD3	6194	0.02	0.52	NO
74	PSMA2	PSMA2	PSMA2	6271	0.019	0.52	NO
75	PSMA4	PSMA4	PSMA4	6379	0.018	0.52	NO
76	PSMB5	PSMB5	PSMB5	6385	0.018	0.52	NO
77	PSMB3	PSMB3	PSMB3	6437	0.017	0.52	NO
78	HDAC1	HDAC1	HDAC1	6671	0.014	0.51	NO
79	PSMB9	PSMB9	PSMB9	6695	0.014	0.51	NO
80	E2F4	E2F4	E2F4	6720	0.014	0.51	NO
81	PPP2R1A	PPP2R1A	PPP2R1A	6745	0.014	0.51	NO
82	PPP2CA	PPP2CA	PPP2CA	6752	0.014	0.51	NO
83	PSMB7	PSMB7	PSMB7	6763	0.013	0.51	NO
84	PSMB4	PSMB4	PSMB4	6883	0.012	0.5	NO
85	RBBP4	RBBP4	RBBP4	7143	0.0094	0.49	NO
86	PSMD9	PSMD9	PSMD9	7162	0.0092	0.49	NO
87	MYC	MYC	MYC	7176	0.009	0.49	NO
88	PSMC2	PSMC2	PSMC2	7201	0.0088	0.49	NO
89	PSMB8	PSMB8	PSMB8	7411	0.0065	0.48	NO
90	PSMC5	PSMC5	PSMC5	7439	0.0062	0.48	NO
91	PRIM1	PRIM1	PRIM1	7684	0.0032	0.47	NO
92	PPP2CB	PPP2CB	PPP2CB	7803	0.0017	0.46	NO
93	MCM3	MCM3	MCM3	8011	-0.00046	0.45	NO
94	PSME2	PSME2	PSME2	8112	-0.0015	0.44	NO
95	LIN54	LIN54	LIN54	8197	-0.0024	0.44	NO
96	PSMF1	PSMF1	PSMF1	8251	-0.003	0.44	NO
97	SKP1	SKP1	SKP1	8277	-0.0034	0.44	NO
98	PSME1	PSME1	PSME1	8420	-0.005	0.43	NO
99	E2F5	E2F5	E2F5	8487	-0.0058	0.43	NO
100	FBXO5	FBXO5	FBXO5	8887	-0.01	0.41	NO
101	RPS27A	RPS27A	RPS27A	8932	-0.01	0.4	NO
102	CUL1	CUL1	CUL1	9026	-0.012	0.4	NO
103	RPA2	RPA2	RPA2	9089	-0.012	0.4	NO
104	CDKN1B	CDKN1B	CDKN1B	9103	-0.012	0.4	NO
105	PSMB10	PSMB10	PSMB10	9206	-0.014	0.4	NO
106	PSMB1	PSMB1	PSMB1	9317	-0.015	0.39	NO
107	CCNH	CCNH	CCNH	9461	-0.016	0.39	NO
108	POLA1	POLA1	POLA1	9488	-0.017	0.39	NO
109	PPP2R3B	PPP2R3B	PPP2R3B	9864	-0.021	0.37	NO
110	PSMD6	PSMD6	PSMD6	9911	-0.021	0.37	NO
111	PSMB6	PSMB6	PSMB6	10392	-0.026	0.34	NO
112	RB1	RB1	RB1	10458	-0.027	0.34	NO
113	RBL2	RBL2	RBL2	10469	-0.028	0.35	NO
114	LIN52	LIN52	LIN52	10507	-0.028	0.35	NO
115	RPA1	RPA1	RPA1	10536	-0.028	0.35	NO
116	MAX	MAX	MAX	10558	-0.029	0.35	NO
117	CDKN2C	CDKN2C	CDKN2C	11098	-0.036	0.33	NO
118	UBA52	UBA52	UBA52	11476	-0.042	0.31	NO
119	DYRK1A	DYRK1A	DYRK1A	11509	-0.043	0.32	NO
120	PPP2R1B	PPP2R1B	PPP2R1B	11667	-0.046	0.31	NO
121	CCND3	CCND3	CCND3	11961	-0.051	0.3	NO
122	RPA4	RPA4	RPA4	14716	-0.13	0.17	NO
123	CCNA1	CCNA1	CCNA1	15153	-0.15	0.16	NO
124	CCND2	CCND2	CCND2	15348	-0.16	0.17	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	KRT14	KRT14	KRT14	42	0.54	0.075	YES
2	KRT5	KRT5	KRT5	63	0.5	0.15	YES
3	TP63	TP63	TP63	115	0.44	0.21	YES
4	DLX5	DLX5	DLX5	257	0.35	0.25	YES
5	IL1A	IL1A	IL1A	383	0.31	0.29	YES
6	CCNB2	CCNB2	CCNB2	440	0.3	0.33	YES
7	SFN	SFN	SFN	450	0.29	0.37	YES
8	RAB38	RAB38	RAB38	688	0.25	0.39	YES
9	TOP2A	TOP2A	TOP2A	735	0.24	0.42	YES
10	RRAD	RRAD	RRAD	751	0.24	0.46	YES
11	ITGA3	ITGA3	ITGA3	777	0.23	0.49	YES
12	HELLS	HELLS	HELLS	879	0.22	0.51	YES
13	AXL	AXL	AXL	985	0.21	0.54	YES
14	ADA	ADA	ADA	1031	0.2	0.56	YES
15	IGFBP3	IGFBP3	IGFBP3	1206	0.18	0.58	YES
16	COL5A1	COL5A1	COL5A1	1209	0.18	0.61	YES
17	DLX6	DLX6	DLX6	1360	0.17	0.62	YES
18	BRCA2	BRCA2	BRCA2	1413	0.16	0.64	YES
19	SEC14L2	SEC14L2	SEC14L2	1572	0.15	0.66	YES
20	PERP	PERP	PERP	1900	0.12	0.66	YES
21	RUNX1	RUNX1	RUNX1	2147	0.11	0.66	YES
22	VDR	VDR	VDR	2157	0.11	0.68	YES
23	YAP1	YAP1	YAP1	2287	0.1	0.68	YES
24	FOSL2	FOSL2	FOSL2	2648	0.088	0.68	NO
25	TCF7L1	TCF7L1	TCF7L1	3111	0.074	0.66	NO
26	ITCH	ITCH	ITCH	3867	0.055	0.63	NO
27	MRE11A	MRE11A	MRE11A	4172	0.049	0.62	NO
28	ADRM1	ADRM1	ADRM1	4338	0.046	0.62	NO
29	GSK3B	GSK3B	GSK3B	4390	0.045	0.62	NO
30	MDM2	MDM2	MDM2	4867	0.037	0.6	NO
31	HES1	HES1	HES1	5042	0.035	0.6	NO
32	FASN	FASN	FASN	5233	0.032	0.59	NO
33	NOTCH1	NOTCH1	NOTCH1	6007	0.022	0.55	NO
34	HBP1	HBP1	HBP1	6017	0.022	0.55	NO
35	CDKN2A	CDKN2A	CDKN2A	6115	0.021	0.55	NO
36	WWP1	WWP1	WWP1	7205	0.0088	0.49	NO
37	CEBPD	CEBPD	CEBPD	7371	0.007	0.48	NO
38	GNB2L1	GNB2L1	GNB2L1	8862	-0.0097	0.41	NO
39	NRG1	NRG1	NRG1	10870	-0.033	0.3	NO
40	BDKRB2	BDKRB2	BDKRB2	11491	-0.043	0.27	NO
41	ATM	ATM	ATM	11624	-0.045	0.27	NO
42	FBXW7	FBXW7	FBXW7	12894	-0.07	0.22	NO
43	PPP2R5A	PPP2R5A	PPP2R5A	13073	-0.074	0.22	NO
44	STXBP4	STXBP4	STXBP4	15143	-0.15	0.12	NO
45	GPX2	GPX2	GPX2	15298	-0.16	0.14	NO
46	POU2F2	POU2F2	POU2F2	16209	-0.22	0.12	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	FANCB	FANCB	FANCB	357	0.32	0.031	YES
2	FANCA	FANCA	FANCA	397	0.3	0.077	YES
3	BRIP1	BRIP1	BRIP1	412	0.3	0.12	YES
4	RAD51	RAD51	RAD51	517	0.28	0.16	YES
5	POLE2	POLE2	POLE2	857	0.22	0.18	YES
6	C19orf40	C19orf40	C19orf40	1068	0.2	0.2	YES
7	UBE2T	UBE2T	UBE2T	1300	0.17	0.21	YES
8	RFC4	RFC4	RFC4	1365	0.17	0.24	YES
9	BRCA2	BRCA2	BRCA2	1413	0.16	0.26	YES
10	FANCD2	FANCD2	FANCD2	1459	0.16	0.28	YES
11	FANCE	FANCE	FANCE	2041	0.12	0.27	YES
12	POLB	POLB	POLB	2094	0.11	0.28	YES
13	MNAT1	MNAT1	MNAT1	2403	0.098	0.28	YES
14	RFC2	RFC2	RFC2	2435	0.097	0.3	YES
15	H2AFX	H2AFX	H2AFX	2484	0.095	0.31	YES
16	POLD1	POLD1	POLD1	2510	0.094	0.32	YES
17	POLR2H	POLR2H	POLR2H	2538	0.092	0.34	YES
18	FEN1	FEN1	FEN1	2771	0.084	0.34	YES
19	FANCG	FANCG	FANCG	3126	0.073	0.33	YES
20	PALB2	PALB2	PALB2	3264	0.07	0.33	YES
21	RPA3	RPA3	RPA3	3390	0.067	0.34	YES
22	GTF2H3	GTF2H3	GTF2H3	3447	0.066	0.34	YES
23	RFC5	RFC5	RFC5	3577	0.062	0.35	YES
24	CDK7	CDK7	CDK7	3599	0.061	0.36	YES
25	PRKDC	PRKDC	PRKDC	3620	0.061	0.36	YES
26	POLR2D	POLR2D	POLR2D	3787	0.057	0.36	YES
27	LIG1	LIG1	LIG1	3804	0.056	0.37	YES
28	MPG	MPG	MPG	3839	0.056	0.38	YES
29	MAD2L2	MAD2L2	MAD2L2	3847	0.056	0.39	YES
30	TCEA1	TCEA1	TCEA1	3929	0.054	0.39	YES
31	BRCA1	BRCA1	BRCA1	3945	0.053	0.4	YES
32	POLD4	POLD4	POLD4	4167	0.049	0.4	YES
33	MRE11A	MRE11A	MRE11A	4172	0.049	0.4	YES
34	PCNA	PCNA	PCNA	4202	0.048	0.41	YES
35	ERCC3	ERCC3	ERCC3	4346	0.046	0.41	YES
36	RFC3	RFC3	RFC3	4368	0.045	0.42	YES
37	ERCC2	ERCC2	ERCC2	4370	0.045	0.42	YES
38	C17orf70	C17orf70	C17orf70	4403	0.045	0.43	YES
39	GTF2H4	GTF2H4	GTF2H4	4543	0.042	0.43	NO
40	ATR	ATR	ATR	4674	0.04	0.43	NO
41	XRCC5	XRCC5	XRCC5	4870	0.037	0.42	NO
42	POLR2K	POLR2K	POLR2K	4930	0.036	0.42	NO
43	POLE	POLE	POLE	5120	0.034	0.42	NO
44	TP53BP1	TP53BP1	TP53BP1	5273	0.032	0.42	NO
45	MGMT	MGMT	MGMT	5379	0.03	0.41	NO
46	TDP1	TDP1	TDP1	5678	0.026	0.4	NO
47	FANCL	FANCL	FANCL	5823	0.024	0.4	NO
48	XRCC1	XRCC1	XRCC1	5868	0.024	0.4	NO
49	USP1	USP1	USP1	5885	0.023	0.4	NO
50	NBN	NBN	NBN	5912	0.023	0.4	NO
51	DDB2	DDB2	DDB2	5915	0.023	0.41	NO
52	APEX1	APEX1	APEX1	5981	0.022	0.41	NO
53	POLR2G	POLR2G	POLR2G	6039	0.022	0.41	NO
54	XRCC6	XRCC6	XRCC6	6049	0.021	0.41	NO
55	TDG	TDG	TDG	6266	0.019	0.4	NO
56	POLR2I	POLR2I	POLR2I	6411	0.017	0.4	NO
57	ALKBH2	ALKBH2	ALKBH2	6451	0.017	0.4	NO
58	RAD23B	RAD23B	RAD23B	6561	0.015	0.4	NO
59	ERCC1	ERCC1	ERCC1	6578	0.015	0.4	NO
60	REV1	REV1	REV1	6649	0.014	0.4	NO
61	GTF2H2	GTF2H2	GTF2H2	6864	0.012	0.38	NO
62	NTHL1	NTHL1	NTHL1	7003	0.011	0.38	NO
63	POLD2	POLD2	POLD2	7077	0.01	0.38	NO
64	DDB1	DDB1	DDB1	7222	0.0086	0.37	NO
65	LIG3	LIG3	LIG3	7262	0.0082	0.37	NO
66	POLR2L	POLR2L	POLR2L	7504	0.0054	0.36	NO
67	POLR2C	POLR2C	POLR2C	7549	0.0049	0.36	NO
68	ERCC6	ERCC6	ERCC6	7603	0.0041	0.35	NO
69	POLR2F	POLR2F	POLR2F	7642	0.0036	0.35	NO
70	MUTYH	MUTYH	MUTYH	7671	0.0033	0.35	NO
71	CCNO	CCNO	CCNO	7685	0.0031	0.35	NO
72	POLR2E	POLR2E	POLR2E	7829	0.0014	0.34	NO
73	SMUG1	SMUG1	SMUG1	8241	-0.003	0.32	NO
74	GTF2H1	GTF2H1	GTF2H1	8344	-0.0042	0.32	NO
75	MBD4	MBD4	MBD4	8705	-0.008	0.3	NO
76	RPS27A	RPS27A	RPS27A	8932	-0.01	0.29	NO
77	RAD50	RAD50	RAD50	9044	-0.012	0.28	NO
78	RPA2	RPA2	RPA2	9089	-0.012	0.28	NO
79	POLR2A	POLR2A	POLR2A	9134	-0.013	0.28	NO
80	FANCM	FANCM	FANCM	9186	-0.014	0.28	NO
81	XAB2	XAB2	XAB2	9309	-0.015	0.28	NO
82	POLR2B	POLR2B	POLR2B	9455	-0.016	0.27	NO
83	CCNH	CCNH	CCNH	9461	-0.016	0.27	NO
84	POLR2J	POLR2J	POLR2J	9639	-0.018	0.27	NO
85	POLD3	POLD3	POLD3	9730	-0.019	0.27	NO
86	ERCC8	ERCC8	ERCC8	9949	-0.022	0.26	NO
87	FANCF	FANCF	FANCF	9983	-0.022	0.26	NO
88	RPA1	RPA1	RPA1	10536	-0.028	0.23	NO
89	MDC1	MDC1	MDC1	10550	-0.029	0.24	NO
90	OGG1	OGG1	OGG1	10623	-0.03	0.24	NO
91	ALKBH3	ALKBH3	ALKBH3	10981	-0.035	0.22	NO
92	RAD52	RAD52	RAD52	11343	-0.04	0.21	NO
93	UBA52	UBA52	UBA52	11476	-0.042	0.21	NO
94	XPC	XPC	XPC	11488	-0.043	0.22	NO
95	ATM	ATM	ATM	11624	-0.045	0.22	NO
96	ERCC5	ERCC5	ERCC5	11723	-0.046	0.22	NO
97	POLH	POLH	POLH	12317	-0.058	0.2	NO
98	ERCC4	ERCC4	ERCC4	12330	-0.058	0.2	NO
99	LIG4	LIG4	LIG4	13015	-0.073	0.18	NO
100	FANCC	FANCC	FANCC	13242	-0.079	0.18	NO
101	XPA	XPA	XPA	13539	-0.087	0.18	NO
102	XRCC4	XRCC4	XRCC4	14442	-0.12	0.15	NO
103	ZBTB32	ZBTB32	ZBTB32	14587	-0.13	0.16	NO
104	REV3L	REV3L	REV3L	14756	-0.13	0.17	NO
105	GTF2H2B	GTF2H2B	GTF2H2B	15863	-0.2	0.14	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus4 enriched pathways

Table 6. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus4. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
KEGG FATTY ACID METABOLISM	38	genes.ES.table	0.6	1.8	0.004	0.26	0.6	0.21	0.093	0.19	0.088	0.069
KEGG SELENOAMINO ACID METABOLISM	26	genes.ES.table	0.76	2.3	0	0.082	0.021	0.19	0.03	0.19	0	0.021
KEGG GLUTATHIONE METABOLISM	46	genes.ES.table	0.6	1.9	0	0.2	0.36	0.11	0.028	0.11	0	0.049
KEGG GLYCEROLIPID METABOLISM	48	genes.ES.table	0.65	2	0	0.2	0.11	0.1	0.014	0.1	0	0.05
KEGG PROPANOATE METABOLISM	32	genes.ES.table	0.56	1.9	0.0041	0.22	0.35	0.56	0.28	0.41	0	0.055
KEGG ENDOCYTOSIS	179	genes.ES.table	0.39	1.8	0	0.24	0.5	0.26	0.25	0.2	0	0.06
SIG PIP3 SIGNALING IN CARDIAC MYOCTES	67	genes.ES.table	0.52	2	0	0.18	0.13	0.12	0.086	0.11	0	0.047
SIG CHEMOTAXIS	44	genes.ES.table	0.59	1.8	0.0021	0.23	0.51	0.16	0.086	0.15	0.059	0.059
SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	35	genes.ES.table	0.61	1.9	0	0.26	0.28	0.086	0.018	0.084	0	0.06
PID INSULIN PATHWAY	45	genes.ES.table	0.49	1.9	0.0021	0.25	0.23	0.31	0.26	0.23	0	0.06

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MAT1A	MAT1A	MAT1A	158	0.63	0.2	YES
2	CBS	CBS	CBS	191	0.58	0.4	YES
3	GGT6	GGT6	GGT6	412	0.41	0.52	YES
4	GGT1	GGT1	GGT1	518	0.36	0.64	YES
5	CTH	CTH	CTH	554	0.35	0.76	YES
6	SCLY	SCLY	SCLY	1937	0.17	0.74	NO
7	GGT7	GGT7	GGT7	4489	0.066	0.62	NO
8	AHCYL1	AHCYL1	AHCYL1	4679	0.062	0.63	NO
9	LCMT2	LCMT2	LCMT2	5585	0.046	0.6	NO
10	PAPSS1	PAPSS1	PAPSS1	6214	0.037	0.57	NO
11	MARS2	MARS2	MARS2	6606	0.032	0.56	NO
12	PAPSS2	PAPSS2	PAPSS2	7018	0.027	0.55	NO
13	MAT2B	MAT2B	MAT2B	7088	0.026	0.56	NO
14	MAT2A	MAT2A	MAT2A	7577	0.022	0.54	NO
15	AHCYL2	AHCYL2	AHCYL2	7628	0.021	0.54	NO
16	GGT5	GGT5	GGT5	8136	0.016	0.52	NO
17	LCMT1	LCMT1	LCMT1	8321	0.014	0.51	NO
18	SEPHS1	SEPHS1	SEPHS1	8626	0.011	0.5	NO
19	METTL2B	METTL2B	METTL2B	9346	0.0041	0.46	NO
20	METTL6	METTL6	METTL6	9688	0.0012	0.44	NO
21	SEPHS2	SEPHS2	SEPHS2	9778	0.00046	0.44	NO
22	HEMK1	HEMK1	HEMK1	9934	-0.00073	0.43	NO
23	MARS	MARS	MARS	10468	-0.0054	0.41	NO
24	AHCY	AHCY	AHCY	10508	-0.0057	0.4	NO
25	TRMT11	TRMT11	TRMT11	12457	-0.024	0.31	NO
26	WBSCR22	WBSCR22	WBSCR22	14632	-0.053	0.21	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	EGF	EGF	EGF	52	1	0.22	YES
2	ERBB4	ERBB4	ERBB4	74	0.86	0.42	YES
3	NRG4	NRG4	NRG4	144	0.64	0.56	YES
4	NRG2	NRG2	NRG2	674	0.32	0.6	YES
5	PHLPP1	PHLPP1	PHLPP1	2165	0.15	0.55	NO
6	EGFR	EGFR	EGFR	2872	0.12	0.54	NO
7	FOXO3	FOXO3	FOXO3	3797	0.084	0.51	NO
8	CASP9	CASP9	CASP9	3916	0.08	0.52	NO
9	GAB1	GAB1	GAB1	4477	0.066	0.5	NO
10	PIK3R1	PIK3R1	PIK3R1	4539	0.065	0.51	NO
11	AKT3	AKT3	AKT3	4561	0.065	0.53	NO
12	FOXO4	FOXO4	FOXO4	4886	0.058	0.52	NO
13	PIK3CA	PIK3CA	PIK3CA	5589	0.046	0.5	NO
14	FOXO1	FOXO1	FOXO1	5701	0.044	0.5	NO
15	PDPK1	PDPK1	PDPK1	5702	0.044	0.51	NO
16	THEM4	THEM4	THEM4	5835	0.042	0.51	NO
17	PTEN	PTEN	PTEN	6302	0.036	0.49	NO
18	MTOR	MTOR	MTOR	6342	0.035	0.5	NO
19	ERBB3	ERBB3	ERBB3	6719	0.03	0.48	NO
20	MAPKAP1	MAPKAP1	MAPKAP1	6993	0.028	0.48	NO
21	BTC	BTC	BTC	7279	0.024	0.47	NO
22	CREB1	CREB1	CREB1	7490	0.022	0.46	NO
23	TRIB3	TRIB3	TRIB3	7930	0.018	0.44	NO
24	RICTOR	RICTOR	RICTOR	9171	0.0059	0.37	NO
25	CHUK	CHUK	CHUK	9228	0.0054	0.37	NO
26	CDKN1B	CDKN1B	CDKN1B	9491	0.0028	0.36	NO
27	GRB2	GRB2	GRB2	9686	0.0012	0.35	NO
28	NRG1	NRG1	NRG1	9829	0.000096	0.34	NO
29	MDM2	MDM2	MDM2	10293	-0.0039	0.32	NO
30	AKT1	AKT1	AKT1	11563	-0.015	0.25	NO
31	ERBB2	ERBB2	ERBB2	11821	-0.018	0.24	NO
32	MLST8	MLST8	MLST8	11860	-0.018	0.24	NO
33	TSC2	TSC2	TSC2	12129	-0.02	0.23	NO
34	AKT2	AKT2	AKT2	12227	-0.021	0.23	NO
35	RPS6KB2	RPS6KB2	RPS6KB2	12422	-0.023	0.23	NO
36	HBEGF	HBEGF	HBEGF	13015	-0.029	0.2	NO
37	GSK3A	GSK3A	GSK3A	13311	-0.033	0.19	NO
38	AKT1S1	AKT1S1	AKT1S1	13907	-0.041	0.17	NO
39	CDKN1A	CDKN1A	CDKN1A	14113	-0.044	0.17	NO
40	BAD	BAD	BAD	14636	-0.053	0.15	NO
41	NR4A1	NR4A1	NR4A1	15984	-0.087	0.098	NO
42	EREG	EREG	EREG	17401	-0.16	0.057	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PNLIPRP1	PNLIPRP1	PNLIPRP1	10	1.3	0.16	YES
2	PNLIPRP2	PNLIPRP2	PNLIPRP2	18	1.3	0.31	YES
3	PNLIP	PNLIP	PNLIP	23	1.2	0.46	YES
4	CEL	CEL	CEL	26	1.2	0.6	YES
5	LIPC	LIPC	LIPC	251	0.52	0.65	YES
6	ALDH3A2	ALDH3A2	ALDH3A2	1453	0.2	0.61	NO
7	DGKB	DGKB	DGKB	2077	0.16	0.6	NO
8	LIPG	LIPG	LIPG	2570	0.13	0.59	NO
9	PPAP2C	PPAP2C	PPAP2C	2984	0.11	0.58	NO
10	GPAM	GPAM	GPAM	3004	0.11	0.59	NO
11	PPAP2B	PPAP2B	PPAP2B	3329	0.098	0.58	NO
12	LPL	LPL	LPL	4268	0.071	0.54	NO
13	AGPAT3	AGPAT3	AGPAT3	4855	0.058	0.52	NO
14	ALDH7A1	ALDH7A1	ALDH7A1	4860	0.058	0.52	NO
15	MBOAT1	MBOAT1	MBOAT1	5043	0.055	0.52	NO
16	LIPF	LIPF	LIPF	5592	0.046	0.5	NO
17	AGPAT4	AGPAT4	AGPAT4	5872	0.042	0.48	NO
18	PPAP2A	PPAP2A	PPAP2A	6219	0.037	0.47	NO
19	AKR1B1	AKR1B1	AKR1B1	6318	0.035	0.47	NO
20	AGPAT6	AGPAT6	AGPAT6	6338	0.035	0.47	NO
21	ALDH9A1	ALDH9A1	ALDH9A1	7998	0.017	0.38	NO
22	AKR1A1	AKR1A1	AKR1A1	8352	0.014	0.37	NO
23	GK	GK	GK	8753	0.0099	0.35	NO
24	ALDH2	ALDH2	ALDH2	9447	0.0032	0.31	NO
25	DAK	DAK	DAK	9669	0.0014	0.3	NO
26	GLA	GLA	GLA	10171	-0.0029	0.27	NO
27	AGPAT1	AGPAT1	AGPAT1	10273	-0.0038	0.27	NO
28	LCLAT1	LCLAT1	LCLAT1	11416	-0.014	0.2	NO
29	ALDH1B1	ALDH1B1	ALDH1B1	11559	-0.015	0.2	NO
30	DGKH	DGKH	DGKH	12028	-0.019	0.18	NO
31	AGPAT2	AGPAT2	AGPAT2	12167	-0.021	0.17	NO
32	PNPLA3	PNPLA3	PNPLA3	12519	-0.024	0.16	NO
33	DGKE	DGKE	DGKE	12555	-0.025	0.16	NO
34	AGPAT9	AGPAT9	AGPAT9	12725	-0.026	0.15	NO
35	AWAT2	AWAT2	AWAT2	12755	-0.027	0.15	NO
36	AGK	AGK	AGK	13908	-0.041	0.094	NO
37	GPAT2	GPAT2	GPAT2	13929	-0.041	0.098	NO
38	DGKG	DGKG	DGKG	14708	-0.055	0.062	NO
39	DGKZ	DGKZ	DGKZ	14838	-0.057	0.062	NO
40	DGKD	DGKD	DGKD	15064	-0.062	0.057	NO
41	MGLL	MGLL	MGLL	15674	-0.077	0.034	NO
42	DGKQ	DGKQ	DGKQ	16006	-0.088	0.026	NO
43	DGKA	DGKA	DGKA	16532	-0.11	0.011	NO
44	DGAT1	DGAT1	DGAT1	16625	-0.12	0.019	NO
45	GLYCTK	GLYCTK	GLYCTK	16755	-0.12	0.027	NO
46	DGKI	DGKI	DGKI	17095	-0.14	0.025	NO
47	MBOAT2	MBOAT2	MBOAT2	17495	-0.17	0.024	NO
48	DGAT2	DGAT2	DGAT2	18086	-0.24	0.02	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ERBB4	ERBB4	ERBB4	74	0.86	0.15	YES
2	PAK7	PAK7	PAK7	81	0.83	0.3	YES
3	PAK3	PAK3	PAK3	325	0.45	0.37	YES
4	F2RL2	F2RL2	F2RL2	662	0.32	0.41	YES
5	IGF1	IGF1	IGF1	1038	0.25	0.44	YES
6	CREB5	CREB5	CREB5	1291	0.22	0.46	YES
7	IRS4	IRS4	IRS4	1379	0.21	0.5	YES
8	PIK3R5	PIK3R5	PIK3R5	1584	0.19	0.52	YES
9	PARD6A	PARD6A	PARD6A	3019	0.11	0.46	NO
10	PIK3CD	PIK3CD	PIK3CD	3035	0.11	0.48	NO
11	PREX1	PREX1	PREX1	3448	0.094	0.47	NO
12	FOXO3	FOXO3	FOXO3	3797	0.084	0.47	NO
13	RPS6KA2	RPS6KA2	RPS6KA2	4361	0.069	0.45	NO
14	PARD3	PARD3	PARD3	4458	0.067	0.46	NO
15	PPP1R13B	PPP1R13B	PPP1R13B	4465	0.067	0.47	NO
16	GAB1	GAB1	GAB1	4477	0.066	0.48	NO
17	SOS2	SOS2	SOS2	4531	0.065	0.49	NO
18	AKT3	AKT3	AKT3	4561	0.065	0.5	NO
19	PIK3CA	PIK3CA	PIK3CA	5589	0.046	0.45	NO
20	CYTH3	CYTH3	CYTH3	6247	0.036	0.42	NO
21	PTEN	PTEN	PTEN	6302	0.036	0.43	NO
22	MTOR	MTOR	MTOR	6342	0.035	0.43	NO
23	MYC	MYC	MYC	6349	0.035	0.44	NO
24	SOS1	SOS1	SOS1	6382	0.034	0.44	NO
25	RPS6KB1	RPS6KB1	RPS6KB1	7477	0.022	0.39	NO
26	CREB1	CREB1	CREB1	7490	0.022	0.39	NO
27	YWHAQ	YWHAQ	YWHAQ	8541	0.012	0.34	NO
28	PTK2	PTK2	PTK2	8715	0.01	0.33	NO
29	PAK6	PAK6	PAK6	8949	0.008	0.32	NO
30	RPS6KA3	RPS6KA3	RPS6KA3	9062	0.007	0.31	NO
31	YWHAE	YWHAE	YWHAE	9253	0.0052	0.3	NO
32	CDKN1B	CDKN1B	CDKN1B	9491	0.0028	0.29	NO
33	GRB2	GRB2	GRB2	9686	0.0012	0.28	NO
34	MET	MET	MET	9731	0.00083	0.28	NO
35	TSC1	TSC1	TSC1	9983	-0.0011	0.26	NO
36	GSK3B	GSK3B	GSK3B	10067	-0.0019	0.26	NO
37	PAK2	PAK2	PAK2	10118	-0.0025	0.26	NO
38	IRS1	IRS1	IRS1	10266	-0.0037	0.25	NO
39	CDK2	CDK2	CDK2	10557	-0.0062	0.24	NO
40	CDC42	CDC42	CDC42	10625	-0.0068	0.23	NO
41	CREB3	CREB3	CREB3	10787	-0.0081	0.23	NO
42	SHC1	SHC1	SHC1	11438	-0.014	0.19	NO
43	AKT1	AKT1	AKT1	11563	-0.015	0.19	NO
44	YWHAB	YWHAB	YWHAB	11921	-0.018	0.17	NO
45	YWHAZ	YWHAZ	YWHAZ	11942	-0.019	0.18	NO
46	INPPL1	INPPL1	INPPL1	11969	-0.019	0.18	NO
47	TSC2	TSC2	TSC2	12129	-0.02	0.17	NO
48	NOLC1	NOLC1	NOLC1	12226	-0.021	0.17	NO
49	AKT2	AKT2	AKT2	12227	-0.021	0.18	NO
50	YWHAG	YWHAG	YWHAG	12250	-0.022	0.18	NO
51	SLC2A4	SLC2A4	SLC2A4	12270	-0.022	0.18	NO
52	YWHAH	YWHAH	YWHAH	12338	-0.022	0.18	NO
53	RPS6KA1	RPS6KA1	RPS6KA1	12660	-0.026	0.17	NO
54	PAK1	PAK1	PAK1	13035	-0.03	0.15	NO
55	PTPN1	PTPN1	PTPN1	13058	-0.03	0.16	NO
56	GADD45A	GADD45A	GADD45A	13140	-0.031	0.16	NO
57	IRS2	IRS2	IRS2	13175	-0.031	0.16	NO
58	GSK3A	GSK3A	GSK3A	13311	-0.033	0.16	NO
59	CDKN2A	CDKN2A	CDKN2A	13653	-0.037	0.15	NO
60	BCL2L1	BCL2L1	BCL2L1	13777	-0.039	0.15	NO
61	EBP	EBP	EBP	14622	-0.053	0.11	NO
62	BAD	BAD	BAD	14636	-0.053	0.12	NO
63	PAK4	PAK4	PAK4	15578	-0.074	0.084	NO
64	PDK1	PDK1	PDK1	15601	-0.075	0.097	NO
65	SFN	SFN	SFN	16074	-0.09	0.087	NO
66	IFI27	IFI27	IFI27	16617	-0.11	0.078	NO
67	IGFBP1	IGFBP1	IGFBP1	16752	-0.12	0.093	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	GRB14	GRB14	GRB14	113	0.72	0.2	YES
2	INS	INS	INS	648	0.33	0.27	YES
3	F2RL2	F2RL2	F2RL2	662	0.32	0.36	YES
4	GRB10	GRB10	GRB10	1187	0.23	0.4	YES
5	SGK1	SGK1	SGK1	1487	0.2	0.45	YES
6	EIF4EBP1	EIF4EBP1	EIF4EBP1	2127	0.15	0.46	YES
7	INSR	INSR	INSR	2848	0.12	0.45	YES
8	PARD6A	PARD6A	PARD6A	3019	0.11	0.48	YES
9	FOXO3	FOXO3	FOXO3	3797	0.084	0.46	YES
10	EXOC6	EXOC6	EXOC6	4313	0.07	0.45	YES
11	CRK	CRK	CRK	4370	0.069	0.47	YES
12	PIK3R1	PIK3R1	PIK3R1	4539	0.065	0.48	YES
13	INPP5D	INPP5D	INPP5D	4844	0.059	0.48	YES
14	NCK2	NCK2	NCK2	4877	0.058	0.49	YES
15	RAPGEF1	RAPGEF1	RAPGEF1	5432	0.048	0.48	NO
16	PIK3CA	PIK3CA	PIK3CA	5589	0.046	0.48	NO
17	PDPK1	PDPK1	PDPK1	5702	0.044	0.49	NO
18	RHOQ	RHOQ	RHOQ	6001	0.04	0.49	NO
19	SOS1	SOS1	SOS1	6382	0.034	0.48	NO
20	EXOC2	EXOC2	EXOC2	7374	0.023	0.43	NO
21	RPS6KB1	RPS6KB1	RPS6KB1	7477	0.022	0.43	NO
22	CBL	CBL	CBL	7570	0.022	0.43	NO
23	DOK1	DOK1	DOK1	7856	0.019	0.42	NO
24	PTPN11	PTPN11	PTPN11	7867	0.019	0.42	NO
25	EXOC5	EXOC5	EXOC5	8271	0.015	0.41	NO
26	EXOC4	EXOC4	EXOC4	8364	0.014	0.41	NO
27	GRB2	GRB2	GRB2	9686	0.0012	0.34	NO
28	PTPRA	PTPRA	PTPRA	9694	0.0011	0.34	NO
29	EXOC7	EXOC7	EXOC7	9770	0.0005	0.33	NO
30	CAV1	CAV1	CAV1	9793	0.00038	0.33	NO
31	EXOC3	EXOC3	EXOC3	10055	-0.0018	0.32	NO
32	SORBS1	SORBS1	SORBS1	10122	-0.0025	0.31	NO
33	RASA1	RASA1	RASA1	10242	-0.0035	0.31	NO
34	IRS1	IRS1	IRS1	10266	-0.0037	0.31	NO
35	SHC1	SHC1	SHC1	11438	-0.014	0.25	NO
36	AKT1	AKT1	AKT1	11563	-0.015	0.25	NO
37	NCK1	NCK1	NCK1	12224	-0.021	0.22	NO
38	AKT2	AKT2	AKT2	12227	-0.021	0.22	NO
39	PTPN1	PTPN1	PTPN1	13058	-0.03	0.19	NO
40	EXOC1	EXOC1	EXOC1	13554	-0.036	0.17	NO
41	PRKCZ	PRKCZ	PRKCZ	13864	-0.04	0.16	NO
42	TRIP10	TRIP10	TRIP10	14310	-0.047	0.16	NO
43	PRKCI	PRKCI	PRKCI	14887	-0.058	0.14	NO
44	HRAS	HRAS	HRAS	15637	-0.076	0.12	NO
45	SH2B2	SH2B2	SH2B2	16433	-0.1	0.11	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MYLK2	MYLK2	MYLK2	12	1.3	0.32	YES
2	PAK7	PAK7	PAK7	81	0.83	0.52	YES
3	PAK3	PAK3	PAK3	325	0.45	0.61	YES
4	FSCN2	FSCN2	FSCN2	1848	0.17	0.57	NO
5	ROCK2	ROCK2	ROCK2	5024	0.056	0.41	NO
6	WASF1	WASF1	WASF1	6380	0.034	0.35	NO
7	CFL2	CFL2	CFL2	6737	0.03	0.34	NO
8	RPS4X	RPS4X	RPS4X	7136	0.026	0.32	NO
9	ROCK1	ROCK1	ROCK1	7349	0.024	0.32	NO
10	FLNA	FLNA	FLNA	8294	0.014	0.27	NO
11	GDI2	GDI2	GDI2	8847	0.009	0.24	NO
12	PAK6	PAK6	PAK6	8949	0.008	0.24	NO
13	ACTR2	ACTR2	ACTR2	9160	0.0061	0.23	NO
14	PFN2	PFN2	PFN2	9997	-0.0013	0.18	NO
15	PAK2	PAK2	PAK2	10118	-0.0025	0.18	NO
16	CDC42	CDC42	CDC42	10625	-0.0068	0.15	NO
17	MYLK	MYLK	MYLK	10773	-0.0079	0.14	NO
18	WASL	WASL	WASL	10779	-0.008	0.14	NO
19	ACTR3	ACTR3	ACTR3	10899	-0.009	0.14	NO
20	LIMK1	LIMK1	LIMK1	11083	-0.011	0.13	NO
21	AKT1	AKT1	AKT1	11563	-0.015	0.11	NO
22	ACTG1	ACTG1	ACTG1	11818	-0.018	0.1	NO
23	PFN1	PFN1	PFN1	12658	-0.026	0.062	NO
24	PAK1	PAK1	PAK1	13035	-0.03	0.049	NO
25	CFL1	CFL1	CFL1	14741	-0.055	-0.031	NO
26	MYH2	MYH2	MYH2	14749	-0.055	-0.018	NO
27	ANGPTL2	ANGPTL2	ANGPTL2	14873	-0.058	-0.01	NO
28	GDI1	GDI1	GDI1	14954	-0.06	-0.000011	NO
29	FSCN3	FSCN3	FSCN3	15084	-0.062	0.0081	NO
30	VASP	VASP	VASP	15509	-0.072	0.0026	NO
31	PAK4	PAK4	PAK4	15578	-0.074	0.017	NO
32	RHO	RHO	RHO	16307	-0.1	0.0016	NO
33	FSCN1	FSCN1	FSCN1	16418	-0.1	0.021	NO
34	FLNC	FLNC	FLNC	16457	-0.11	0.044	NO
35	ACTG2	ACTG2	ACTG2	18237	-0.26	0.012	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CLPS	CLPS	CLPS	17	1.3	0.16	YES
2	PNLIPRP2	PNLIPRP2	PNLIPRP2	18	1.3	0.32	YES
3	PNLIP	PNLIP	PNLIP	23	1.2	0.47	YES
4	ALB	ALB	ALB	65	0.92	0.58	YES
5	LPA	LPA	LPA	135	0.66	0.66	YES
6	LIPC	LIPC	LIPC	251	0.52	0.72	YES
7	FABP4	FABP4	FABP4	1494	0.2	0.67	NO
8	APOC2	APOC2	APOC2	2291	0.14	0.65	NO
9	CUBN	CUBN	CUBN	2718	0.12	0.64	NO
10	PLTP	PLTP	PLTP	2830	0.12	0.65	NO
11	PLIN1	PLIN1	PLIN1	3084	0.11	0.65	NO
12	A2M	A2M	A2M	3101	0.11	0.66	NO
13	LPL	LPL	LPL	4268	0.071	0.61	NO
14	P4HB	P4HB	P4HB	4280	0.071	0.61	NO
15	APOE	APOE	APOE	4325	0.07	0.62	NO
16	PRKACB	PRKACB	PRKACB	5318	0.05	0.57	NO
17	APOA5	APOA5	APOA5	5472	0.047	0.57	NO
18	ABHD5	ABHD5	ABHD5	5724	0.044	0.56	NO
19	ABCA1	ABCA1	ABCA1	6073	0.039	0.55	NO
20	PPP1CB	PPP1CB	PPP1CB	6536	0.032	0.53	NO
21	HSPG2	HSPG2	HSPG2	7647	0.021	0.47	NO
22	ABCG5	ABCG5	ABCG5	8343	0.014	0.43	NO
23	PPP1CC	PPP1CC	PPP1CC	8840	0.0091	0.41	NO
24	PRKACA	PRKACA	PRKACA	8982	0.0077	0.4	NO
25	CAV1	CAV1	CAV1	9793	0.00038	0.36	NO
26	SAR1B	SAR1B	SAR1B	10336	-0.0042	0.33	NO
27	PPP1CA	PPP1CA	PPP1CA	10362	-0.0044	0.33	NO
28	CETP	CETP	CETP	11153	-0.011	0.29	NO
29	LDLRAP1	LDLRAP1	LDLRAP1	11293	-0.013	0.28	NO
30	LDLR	LDLR	LDLR	11543	-0.015	0.27	NO
31	MTTP	MTTP	MTTP	11585	-0.015	0.27	NO
32	APOB	APOB	APOB	11737	-0.017	0.26	NO
33	APOA1	APOA1	APOA1	12308	-0.022	0.23	NO
34	ABCG8	ABCG8	ABCG8	12608	-0.025	0.22	NO
35	BMP1	BMP1	BMP1	14781	-0.056	0.11	NO
36	SCARB1	SCARB1	SCARB1	14900	-0.059	0.11	NO
37	MGLL	MGLL	MGLL	15674	-0.077	0.078	NO
38	APOC3	APOC3	APOC3	15683	-0.077	0.087	NO
39	LIPE	LIPE	LIPE	15727	-0.078	0.094	NO
40	LCAT	LCAT	LCAT	15845	-0.082	0.098	NO
41	ABCG1	ABCG1	ABCG1	16228	-0.096	0.089	NO
42	SDC1	SDC1	SDC1	16350	-0.1	0.095	NO
43	AMN	AMN	AMN	17312	-0.15	0.062	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	EGF	EGF	EGF	52	1	0.12	YES
2	ERBB4	ERBB4	ERBB4	74	0.86	0.22	YES
3	NRG4	NRG4	NRG4	144	0.64	0.3	YES
4	ADCY5	ADCY5	ADCY5	276	0.5	0.35	YES
5	NRG2	NRG2	NRG2	674	0.32	0.37	YES
6	PRKAR2B	PRKAR2B	PRKAR2B	755	0.3	0.4	YES
7	ITPR2	ITPR2	ITPR2	1041	0.25	0.41	YES
8	MATK	MATK	MATK	1835	0.17	0.39	YES
9	PDE1A	PDE1A	PDE1A	2017	0.16	0.4	YES
10	PHLPP1	PHLPP1	PHLPP1	2165	0.15	0.41	YES
11	ADCY1	ADCY1	ADCY1	2169	0.15	0.43	YES
12	ADCY9	ADCY9	ADCY9	2342	0.14	0.44	YES
13	ADCY8	ADCY8	ADCY8	2582	0.13	0.44	YES
14	EGFR	EGFR	EGFR	2872	0.12	0.44	YES
15	PRKAR2A	PRKAR2A	PRKAR2A	2945	0.11	0.45	YES
16	CAMK4	CAMK4	CAMK4	3461	0.094	0.43	NO
17	FOXO3	FOXO3	FOXO3	3797	0.084	0.42	NO
18	CASP9	CASP9	CASP9	3916	0.08	0.42	NO
19	GAB1	GAB1	GAB1	4477	0.066	0.4	NO
20	PIK3R1	PIK3R1	PIK3R1	4539	0.065	0.41	NO
21	AKT3	AKT3	AKT3	4561	0.065	0.41	NO
22	FOXO4	FOXO4	FOXO4	4886	0.058	0.4	NO
23	PDE1B	PDE1B	PDE1B	5112	0.054	0.4	NO
24	PRKACB	PRKACB	PRKACB	5318	0.05	0.39	NO
25	ADCY4	ADCY4	ADCY4	5446	0.048	0.39	NO
26	PRKCA	PRKCA	PRKCA	5456	0.048	0.4	NO
27	PIK3CA	PIK3CA	PIK3CA	5589	0.046	0.39	NO
28	FOXO1	FOXO1	FOXO1	5701	0.044	0.39	NO
29	PDPK1	PDPK1	PDPK1	5702	0.044	0.4	NO
30	CUL5	CUL5	CUL5	5805	0.043	0.4	NO
31	THEM4	THEM4	THEM4	5835	0.042	0.4	NO
32	MAPK1	MAPK1	MAPK1	6112	0.038	0.39	NO
33	USP8	USP8	USP8	6228	0.036	0.39	NO
34	PRKCE	PRKCE	PRKCE	6252	0.036	0.39	NO
35	PTEN	PTEN	PTEN	6302	0.036	0.39	NO
36	MTOR	MTOR	MTOR	6342	0.035	0.4	NO
37	SOS1	SOS1	SOS1	6382	0.034	0.4	NO
38	ERBB3	ERBB3	ERBB3	6719	0.03	0.38	NO
39	ADCY3	ADCY3	ADCY3	6827	0.029	0.38	NO
40	MAPKAP1	MAPKAP1	MAPKAP1	6993	0.028	0.38	NO
41	RAF1	RAF1	RAF1	7098	0.026	0.37	NO
42	BTC	BTC	BTC	7279	0.024	0.37	NO
43	CREB1	CREB1	CREB1	7490	0.022	0.36	NO
44	TRIB3	TRIB3	TRIB3	7930	0.018	0.34	NO
45	NRAS	NRAS	NRAS	7956	0.018	0.34	NO
46	PRKAR1A	PRKAR1A	PRKAR1A	8087	0.016	0.33	NO
47	YES1	YES1	YES1	8109	0.016	0.33	NO
48	RPS27A	RPS27A	RPS27A	8550	0.012	0.31	NO
49	UBA52	UBA52	UBA52	8864	0.0089	0.29	NO
50	PRKACA	PRKACA	PRKACA	8982	0.0077	0.29	NO
51	GRB7	GRB7	GRB7	9108	0.0066	0.28	NO
52	CALM3	CALM3	CALM3	9151	0.0062	0.28	NO
53	RICTOR	RICTOR	RICTOR	9171	0.0059	0.28	NO
54	PRKCD	PRKCD	PRKCD	9204	0.0056	0.28	NO
55	CHUK	CHUK	CHUK	9228	0.0054	0.28	NO
56	CDKN1B	CDKN1B	CDKN1B	9491	0.0028	0.26	NO
57	GRB2	GRB2	GRB2	9686	0.0012	0.26	NO
58	NRG1	NRG1	NRG1	9829	0.000096	0.25	NO
59	MAP2K1	MAP2K1	MAP2K1	9880	-0.00028	0.24	NO
60	FYN	FYN	FYN	9965	-0.0011	0.24	NO
61	MDM2	MDM2	MDM2	10293	-0.0039	0.22	NO
62	ITPR3	ITPR3	ITPR3	10309	-0.004	0.22	NO
63	RNF41	RNF41	RNF41	10780	-0.008	0.2	NO
64	HSP90AA1	HSP90AA1	HSP90AA1	11007	-0.01	0.19	NO
65	SHC1	SHC1	SHC1	11438	-0.014	0.16	NO
66	AKT1	AKT1	AKT1	11563	-0.015	0.16	NO
67	ERBB2	ERBB2	ERBB2	11821	-0.018	0.15	NO
68	MLST8	MLST8	MLST8	11860	-0.018	0.15	NO
69	YWHAB	YWHAB	YWHAB	11921	-0.018	0.15	NO
70	TSC2	TSC2	TSC2	12129	-0.02	0.14	NO
71	AKT2	AKT2	AKT2	12227	-0.021	0.14	NO
72	CALM1	CALM1	CALM1	12387	-0.023	0.13	NO
73	RPS6KB2	RPS6KB2	RPS6KB2	12422	-0.023	0.13	NO
74	KRAS	KRAS	KRAS	12583	-0.025	0.12	NO
75	HBEGF	HBEGF	HBEGF	13015	-0.029	0.1	NO
76	PLCG1	PLCG1	PLCG1	13023	-0.03	0.11	NO
77	GSK3A	GSK3A	GSK3A	13311	-0.033	0.096	NO
78	MAP2K2	MAP2K2	MAP2K2	13703	-0.038	0.08	NO
79	SRC	SRC	SRC	13791	-0.039	0.08	NO
80	CDC37	CDC37	CDC37	13851	-0.04	0.081	NO
81	ADCY7	ADCY7	ADCY7	13855	-0.04	0.086	NO
82	AKT1S1	AKT1S1	AKT1S1	13907	-0.041	0.088	NO
83	CDKN1A	CDKN1A	CDKN1A	14113	-0.044	0.082	NO
84	STUB1	STUB1	STUB1	14167	-0.045	0.085	NO
85	ADCY6	ADCY6	ADCY6	14221	-0.046	0.088	NO
86	CALM2	CALM2	CALM2	14516	-0.051	0.078	NO
87	BAD	BAD	BAD	14636	-0.053	0.078	NO
88	ADRBK1	ADRBK1	ADRBK1	15466	-0.071	0.041	NO
89	HRAS	HRAS	HRAS	15637	-0.076	0.041	NO
90	ADCY2	ADCY2	ADCY2	15735	-0.078	0.045	NO
91	NR4A1	NR4A1	NR4A1	15984	-0.087	0.042	NO
92	MAPK3	MAPK3	MAPK3	16243	-0.097	0.04	NO
93	PRKAR1B	PRKAR1B	PRKAR1B	16599	-0.11	0.034	NO
94	CDK1	CDK1	CDK1	17367	-0.16	0.012	NO
95	EREG	EREG	EREG	17401	-0.16	0.029	NO
96	PRKCG	PRKCG	PRKCG	18077	-0.23	0.021	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	EGF	EGF	EGF	52	1	0.4	YES
2	PHLPP1	PHLPP1	PHLPP1	2165	0.15	0.34	YES
3	EGFR	EGFR	EGFR	2872	0.12	0.35	YES
4	FOXO3	FOXO3	FOXO3	3797	0.084	0.34	YES
5	CASP9	CASP9	CASP9	3916	0.08	0.36	YES
6	PAG1	PAG1	PAG1	4387	0.068	0.36	YES
7	GAB1	GAB1	GAB1	4477	0.066	0.38	YES
8	PIK3R1	PIK3R1	PIK3R1	4539	0.065	0.41	YES
9	AKT3	AKT3	AKT3	4561	0.065	0.43	YES
10	FOXO4	FOXO4	FOXO4	4886	0.058	0.44	YES
11	PIK3CA	PIK3CA	PIK3CA	5589	0.046	0.42	YES
12	FOXO1	FOXO1	FOXO1	5701	0.044	0.43	YES
13	PDPK1	PDPK1	PDPK1	5702	0.044	0.45	YES
14	THEM4	THEM4	THEM4	5835	0.042	0.46	YES
15	PTEN	PTEN	PTEN	6302	0.036	0.44	YES
16	MTOR	MTOR	MTOR	6342	0.035	0.46	YES
17	MAPKAP1	MAPKAP1	MAPKAP1	6993	0.028	0.43	NO
18	CREB1	CREB1	CREB1	7490	0.022	0.41	NO
19	TRIB3	TRIB3	TRIB3	7930	0.018	0.4	NO
20	RICTOR	RICTOR	RICTOR	9171	0.0059	0.33	NO
21	CHUK	CHUK	CHUK	9228	0.0054	0.33	NO
22	CDKN1B	CDKN1B	CDKN1B	9491	0.0028	0.32	NO
23	GRB2	GRB2	GRB2	9686	0.0012	0.31	NO
24	MDM2	MDM2	MDM2	10293	-0.0039	0.28	NO
25	AKT1	AKT1	AKT1	11563	-0.015	0.21	NO
26	MLST8	MLST8	MLST8	11860	-0.018	0.2	NO
27	TSC2	TSC2	TSC2	12129	-0.02	0.2	NO
28	AKT2	AKT2	AKT2	12227	-0.021	0.2	NO
29	RPS6KB2	RPS6KB2	RPS6KB2	12422	-0.023	0.2	NO
30	CSK	CSK	CSK	12505	-0.024	0.2	NO
31	GSK3A	GSK3A	GSK3A	13311	-0.033	0.17	NO
32	SRC	SRC	SRC	13791	-0.039	0.16	NO
33	AKT1S1	AKT1S1	AKT1S1	13907	-0.041	0.17	NO
34	CDKN1A	CDKN1A	CDKN1A	14113	-0.044	0.18	NO
35	BAD	BAD	BAD	14636	-0.053	0.17	NO
36	NR4A1	NR4A1	NR4A1	15984	-0.087	0.13	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ACSS3	ACSS3	ACSS3	507	0.37	0.11	YES
2	ACSS1	ACSS1	ACSS1	1204	0.23	0.15	YES
3	ALDH3A2	ALDH3A2	ALDH3A2	1453	0.2	0.21	YES
4	ACAT1	ACAT1	ACAT1	1714	0.18	0.27	YES
5	PCCA	PCCA	PCCA	1972	0.16	0.31	YES
6	ABAT	ABAT	ABAT	2215	0.15	0.35	YES
7	ALDH6A1	ALDH6A1	ALDH6A1	2327	0.14	0.4	YES
8	ACACB	ACACB	ACACB	2781	0.12	0.42	YES
9	MLYCD	MLYCD	MLYCD	3100	0.11	0.44	YES
10	LDHB	LDHB	LDHB	3534	0.092	0.45	YES
11	MCEE	MCEE	MCEE	3743	0.085	0.47	YES
12	HIBCH	HIBCH	HIBCH	3890	0.081	0.49	YES
13	ACADM	ACADM	ACADM	3899	0.081	0.52	YES
14	MUT	MUT	MUT	4345	0.07	0.52	YES
15	ALDH7A1	ALDH7A1	ALDH7A1	4860	0.058	0.52	YES
16	ACAT2	ACAT2	ACAT2	4991	0.056	0.53	YES
17	SUCLG1	SUCLG1	SUCLG1	5039	0.055	0.55	YES
18	SUCLG2	SUCLG2	SUCLG2	5154	0.053	0.56	YES
19	LDHAL6A	LDHAL6A	LDHAL6A	6766	0.03	0.48	NO
20	PCCB	PCCB	PCCB	7399	0.023	0.46	NO
21	HADHA	HADHA	HADHA	7796	0.019	0.44	NO
22	ALDH9A1	ALDH9A1	ALDH9A1	7998	0.017	0.44	NO
23	EHHADH	EHHADH	EHHADH	8090	0.016	0.44	NO
24	SUCLA2	SUCLA2	SUCLA2	8531	0.012	0.42	NO
25	ALDH2	ALDH2	ALDH2	9447	0.0032	0.37	NO
26	ALDH1B1	ALDH1B1	ALDH1B1	11559	-0.015	0.26	NO
27	ACACA	ACACA	ACACA	12950	-0.029	0.2	NO
28	ACSS2	ACSS2	ACSS2	13515	-0.035	0.18	NO
29	ECHS1	ECHS1	ECHS1	13715	-0.038	0.18	NO
30	LDHA	LDHA	LDHA	13740	-0.039	0.2	NO
31	LDHAL6B	LDHAL6B	LDHAL6B	15285	-0.067	0.14	NO
32	LDHC	LDHC	LDHC	16303	-0.099	0.12	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus5 enriched pathways

Table 7. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus5. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
KEGG PURINE METABOLISM	155	genes.ES.table	0.34	1.4	0.026	0.25	1	0.22	0.22	0.17	0.19	0.004
KEGG GLYCOSAMINOGLYCAN BIOSYNTHESIS HEPARAN SULFATE	25	genes.ES.table	0.52	1.4	0.054	0.22	0.99	0.48	0.29	0.34	0.16	0.004
KEGG ABC TRANSPORTERS	43	genes.ES.table	0.58	1.5	0.048	0.2	0.98	0.3	0.16	0.26	0.14	0.004
KEGG MAPK SIGNALING PATHWAY	257	genes.ES.table	0.43	1.6	0	0.19	0.93	0.32	0.24	0.24	0.11	0.022
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION	240	genes.ES.table	0.68	1.6	0.0039	0.2	0.92	0.5	0.15	0.43	0.11	0.029
KEGG PHOSPHATIDYLINOSITOL SIGNALING SYSTEM	75	genes.ES.table	0.42	1.5	0.038	0.19	0.97	0.31	0.25	0.23	0.12	0.009
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION	243	genes.ES.table	0.59	1.5	0.004	0.19	0.98	0.43	0.14	0.37	0.13	0.008
KEGG OOCYTE MEIOSIS	109	genes.ES.table	0.42	1.5	0.044	0.18	0.96	0.26	0.3	0.18	0.11	0.01
KEGG MTOR SIGNALING PATHWAY	52	genes.ES.table	0.43	1.5	0.052	0.19	0.98	0.25	0.25	0.19	0.13	0.005
KEGG APOPTOSIS	85	genes.ES.table	0.49	1.7	0.027	0.24	0.85	0.33	0.25	0.25	0.11	0.039

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CD28	CD28	CD28	64	0.76	0.09	YES
2	CD247	CD247	CD247	210	0.62	0.16	YES
3	CD8B	CD8B	CD8B	261	0.6	0.23	YES
4	PSMA8	PSMA8	PSMA8	519	0.5	0.28	YES
5	DOCK2	DOCK2	DOCK2	575	0.49	0.34	YES
6	LCK	LCK	LCK	951	0.41	0.37	YES
7	AP1S2	AP1S2	AP1S2	1467	0.32	0.38	YES
8	HCK	HCK	HCK	1771	0.29	0.4	YES
9	ELMO1	ELMO1	ELMO1	1850	0.28	0.43	YES
10	CD4	CD4	CD4	1968	0.27	0.46	YES
11	FYN	FYN	FYN	2277	0.24	0.47	YES
12	APOBEC3G	APOBEC3G	APOBEC3G	2730	0.21	0.47	YES
13	PSIP1	PSIP1	PSIP1	3671	0.15	0.44	NO
14	CCNT1	CCNT1	CCNT1	3868	0.14	0.44	NO
15	NUP153	NUP153	NUP153	4779	0.099	0.41	NO
16	PSMB9	PSMB9	PSMB9	5213	0.085	0.39	NO
17	AP1B1	AP1B1	AP1B1	5627	0.073	0.38	NO
18	NUP210	NUP210	NUP210	5664	0.072	0.39	NO
19	NUP50	NUP50	NUP50	5738	0.07	0.39	NO
20	AP1M1	AP1M1	AP1M1	6218	0.059	0.37	NO
21	NUP88	NUP88	NUP88	6415	0.054	0.37	NO
22	PACS1	PACS1	PACS1	6975	0.043	0.34	NO
23	NUP43	NUP43	NUP43	7120	0.041	0.34	NO
24	PAK2	PAK2	PAK2	7151	0.04	0.34	NO
25	RANBP2	RANBP2	RANBP2	7191	0.039	0.35	NO
26	B2M	B2M	B2M	7205	0.039	0.35	NO
27	PSME4	PSME4	PSME4	7382	0.036	0.35	NO
28	NUP188	NUP188	NUP188	7525	0.034	0.34	NO
29	PSMD5	PSMD5	PSMD5	7724	0.031	0.34	NO
30	CUL5	CUL5	CUL5	7783	0.03	0.34	NO
31	PSMB8	PSMB8	PSMB8	7798	0.03	0.34	NO
32	NUP93	NUP93	NUP93	7850	0.029	0.34	NO
33	NUP107	NUP107	NUP107	7999	0.027	0.34	NO
34	NUP155	NUP155	NUP155	8087	0.026	0.34	NO
35	NUP205	NUP205	NUP205	8092	0.026	0.34	NO
36	KPNA1	KPNA1	KPNA1	8241	0.024	0.33	NO
37	AP2M1	AP2M1	AP2M1	8816	0.017	0.3	NO
38	RBX1	RBX1	RBX1	8819	0.017	0.3	NO
39	PSMC2	PSMC2	PSMC2	9004	0.014	0.3	NO
40	UBA52	UBA52	UBA52	9019	0.014	0.3	NO
41	NUPL1	NUPL1	NUPL1	9057	0.014	0.3	NO
42	RPS27A	RPS27A	RPS27A	9064	0.014	0.3	NO
43	KPNB1	KPNB1	KPNB1	9084	0.014	0.3	NO
44	PSMC4	PSMC4	PSMC4	9111	0.013	0.3	NO
45	PSMD11	PSMD11	PSMD11	9198	0.012	0.3	NO
46	TPR	TPR	TPR	9255	0.012	0.3	NO
47	PSMA1	PSMA1	PSMA1	9453	0.0091	0.28	NO
48	BTRC	BTRC	BTRC	9479	0.0087	0.28	NO
49	RANBP1	RANBP1	RANBP1	9535	0.0081	0.28	NO
50	PSMD2	PSMD2	PSMD2	9603	0.0074	0.28	NO
51	RAN	RAN	RAN	9615	0.0073	0.28	NO
52	AP2A1	AP2A1	AP2A1	9619	0.0072	0.28	NO
53	PSMB1	PSMB1	PSMB1	9723	0.006	0.28	NO
54	SLC25A6	SLC25A6	SLC25A6	9813	0.005	0.27	NO
55	PSMD7	PSMD7	PSMD7	9846	0.0047	0.27	NO
56	NUP62	NUP62	NUP62	9880	0.0042	0.27	NO
57	PSMC5	PSMC5	PSMC5	9919	0.0037	0.27	NO
58	HLA-A	HLA-A	HLA-A	9949	0.0034	0.27	NO
59	PSMB2	PSMB2	PSMB2	10007	0.0026	0.26	NO
60	PSMA4	PSMA4	PSMA4	10034	0.0023	0.26	NO
61	NUP214	NUP214	NUP214	10042	0.0022	0.26	NO
62	PSMC1	PSMC1	PSMC1	10049	0.0021	0.26	NO
63	PSMB6	PSMB6	PSMB6	10144	0.0011	0.26	NO
64	NUPL2	NUPL2	NUPL2	10145	0.0011	0.26	NO
65	NUP133	NUP133	NUP133	10155	0.00099	0.26	NO
66	AP2A2	AP2A2	AP2A2	10192	0.0003	0.26	NO
67	XPO1	XPO1	XPO1	10221	-0.000073	0.25	NO
68	PSMD1	PSMD1	PSMD1	10267	-0.00062	0.25	NO
69	PSMD14	PSMD14	PSMD14	10334	-0.0012	0.25	NO
70	PSMA7	PSMA7	PSMA7	10358	-0.0015	0.25	NO
71	POM121	POM121	POM121	10368	-0.0016	0.25	NO
72	PSMA3	PSMA3	PSMA3	10432	-0.0025	0.24	NO
73	NUP37	NUP37	NUP37	10473	-0.003	0.24	NO
74	NUP85	NUP85	NUP85	10634	-0.0047	0.23	NO
75	NUP54	NUP54	NUP54	10715	-0.0055	0.23	NO
76	PSMC3	PSMC3	PSMC3	10778	-0.0061	0.23	NO
77	PSMD12	PSMD12	PSMD12	10810	-0.0065	0.23	NO
78	PSMD10	PSMD10	PSMD10	10820	-0.0066	0.23	NO
79	PSMA6	PSMA6	PSMA6	10958	-0.0083	0.22	NO
80	RAE1	RAE1	RAE1	11046	-0.0094	0.22	NO
81	AP1G1	AP1G1	AP1G1	11047	-0.0094	0.22	NO
82	PSMD13	PSMD13	PSMD13	11051	-0.0094	0.22	NO
83	AP2S1	AP2S1	AP2S1	11253	-0.012	0.21	NO
84	PSMA2	PSMA2	PSMA2	11262	-0.012	0.21	NO
85	PSMA5	PSMA5	PSMA5	11294	-0.012	0.21	NO
86	PSMD8	PSMD8	PSMD8	11503	-0.015	0.2	NO
87	NPM1	NPM1	NPM1	11555	-0.015	0.2	NO
88	TCEB1	TCEB1	TCEB1	11605	-0.016	0.2	NO
89	CDK9	CDK9	CDK9	11663	-0.017	0.2	NO
90	PSMB3	PSMB3	PSMB3	11695	-0.017	0.2	NO
91	PSMB4	PSMB4	PSMB4	11819	-0.019	0.2	NO
92	ATP6V1H	ATP6V1H	ATP6V1H	11834	-0.019	0.2	NO
93	AP2B1	AP2B1	AP2B1	11927	-0.02	0.19	NO
94	PSMC6	PSMC6	PSMC6	11954	-0.02	0.2	NO
95	PSMF1	PSMF1	PSMF1	11970	-0.02	0.2	NO
96	PSMD3	PSMD3	PSMD3	11986	-0.021	0.2	NO
97	PSMD9	PSMD9	PSMD9	12003	-0.021	0.2	NO
98	SEH1L	SEH1L	SEH1L	12051	-0.022	0.2	NO
99	PSMB5	PSMB5	PSMB5	12193	-0.024	0.2	NO
100	SKP1	SKP1	SKP1	12318	-0.025	0.19	NO
101	PSMD6	PSMD6	PSMD6	12380	-0.026	0.19	NO
102	PSMD4	PSMD4	PSMD4	12521	-0.028	0.19	NO
103	PSMB7	PSMB7	PSMB7	12649	-0.03	0.18	NO
104	PSME1	PSME1	PSME1	12893	-0.033	0.18	NO
105	AAAS	AAAS	AAAS	12917	-0.034	0.18	NO
106	RCC1	RCC1	RCC1	12933	-0.034	0.18	NO
107	PPIA	PPIA	PPIA	13030	-0.035	0.18	NO
108	SLC25A5	SLC25A5	SLC25A5	13058	-0.036	0.18	NO
109	PSME2	PSME2	PSME2	13073	-0.036	0.19	NO
110	ARF1	ARF1	ARF1	13134	-0.037	0.19	NO
111	SLC25A4	SLC25A4	SLC25A4	13190	-0.038	0.19	NO
112	BANF1	BANF1	BANF1	13207	-0.038	0.19	NO
113	PSMB10	PSMB10	PSMB10	13216	-0.038	0.2	NO
114	RANGAP1	RANGAP1	RANGAP1	13476	-0.042	0.19	NO
115	NUP35	NUP35	NUP35	13612	-0.044	0.19	NO
116	RAC1	RAC1	RAC1	14257	-0.056	0.16	NO
117	TCEB2	TCEB2	TCEB2	14921	-0.07	0.13	NO
118	HMGA1	HMGA1	HMGA1	15972	-0.1	0.088	NO
119	AP1S1	AP1S1	AP1S1	16146	-0.11	0.092	NO
120	AP1M2	AP1M2	AP1M2	18072	-0.28	0.021	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SLC2A4	SLC2A4	SLC2A4	241	0.61	0.063	YES
2	FABP4	FABP4	FABP4	323	0.57	0.13	YES
3	WNT10B	WNT10B	WNT10B	356	0.56	0.2	YES
4	LEP	LEP	LEP	429	0.53	0.26	YES
5	WNT1	WNT1	WNT1	434	0.53	0.33	YES
6	ADIPOQ	ADIPOQ	ADIPOQ	492	0.51	0.39	YES
7	CD36	CD36	CD36	730	0.45	0.43	YES
8	PLIN1	PLIN1	PLIN1	985	0.41	0.47	YES
9	EBF1	EBF1	EBF1	1006	0.4	0.52	YES
10	LPL	LPL	LPL	1160	0.37	0.56	YES
11	TNF	TNF	TNF	1523	0.32	0.58	YES
12	PCK1	PCK1	PCK1	2243	0.25	0.57	NO
13	EGR2	EGR2	EGR2	2729	0.21	0.57	NO
14	MED13L	MED13L	MED13L	4644	0.1	0.48	NO
15	TGFB1	TGFB1	TGFB1	4995	0.092	0.47	NO
16	NCOA3	NCOA3	NCOA3	5544	0.076	0.45	NO
17	CEBPD	CEBPD	CEBPD	5666	0.072	0.45	NO
18	CDK8	CDK8	CDK8	5720	0.071	0.46	NO
19	CCND3	CCND3	CCND3	5803	0.068	0.46	NO
20	NCOA2	NCOA2	NCOA2	5822	0.068	0.47	NO
21	NR2F2	NR2F2	NR2F2	5963	0.064	0.47	NO
22	CDK19	CDK19	CDK19	6034	0.063	0.48	NO
23	NCOA1	NCOA1	NCOA1	6433	0.054	0.46	NO
24	MED27	MED27	MED27	6639	0.05	0.46	NO
25	TGS1	TGS1	TGS1	6787	0.047	0.45	NO
26	EP300	EP300	EP300	7110	0.041	0.44	NO
27	MED23	MED23	MED23	7371	0.036	0.43	NO
28	MED26	MED26	MED26	7583	0.033	0.42	NO
29	CREBBP	CREBBP	CREBBP	7609	0.033	0.43	NO
30	TBL1X	TBL1X	TBL1X	7683	0.032	0.43	NO
31	MED1	MED1	MED1	7900	0.029	0.42	NO
32	MED8	MED8	MED8	7994	0.027	0.42	NO
33	MED10	MED10	MED10	8097	0.026	0.41	NO
34	NCOR1	NCOR1	NCOR1	8410	0.022	0.4	NO
35	KLF4	KLF4	KLF4	8711	0.018	0.39	NO
36	MED4	MED4	MED4	8748	0.018	0.39	NO
37	MED17	MED17	MED17	8875	0.016	0.38	NO
38	MED31	MED31	MED31	8933	0.015	0.38	NO
39	MED12	MED12	MED12	9117	0.013	0.37	NO
40	MED22	MED22	MED22	9184	0.012	0.37	NO
41	MED14	MED14	MED14	9314	0.011	0.36	NO
42	MED15	MED15	MED15	9527	0.0081	0.35	NO
43	PPARA	PPARA	PPARA	9552	0.0079	0.35	NO
44	MED30	MED30	MED30	9578	0.0076	0.35	NO
45	MED18	MED18	MED18	9632	0.0071	0.35	NO
46	TBL1XR1	TBL1XR1	TBL1XR1	10002	0.0027	0.33	NO
47	CDK4	CDK4	CDK4	10053	0.002	0.33	NO
48	SMARCD3	SMARCD3	SMARCD3	10208	0.000052	0.32	NO
49	MED6	MED6	MED6	10259	-0.00046	0.32	NO
50	HDAC3	HDAC3	HDAC3	10538	-0.0036	0.3	NO
51	CEBPB	CEBPB	CEBPB	10592	-0.0042	0.3	NO
52	RXRA	RXRA	RXRA	10945	-0.0081	0.28	NO
53	MED11	MED11	MED11	11147	-0.01	0.27	NO
54	NCOR2	NCOR2	NCOR2	11190	-0.011	0.27	NO
55	RELA	RELA	RELA	11368	-0.013	0.26	NO
56	CCNC	CCNC	CCNC	11370	-0.013	0.27	NO
57	MED20	MED20	MED20	11750	-0.018	0.25	NO
58	MED29	MED29	MED29	11784	-0.018	0.25	NO
59	MED9	MED9	MED9	12348	-0.026	0.22	NO
60	MED24	MED24	MED24	12575	-0.029	0.21	NO
61	PRIC285	PRIC285	PRIC285	12710	-0.03	0.21	NO
62	NCOA6	NCOA6	NCOA6	13092	-0.036	0.19	NO
63	MED7	MED7	MED7	13197	-0.038	0.19	NO
64	SREBF1	SREBF1	SREBF1	13652	-0.045	0.17	NO
65	ANGPTL4	ANGPTL4	ANGPTL4	13784	-0.047	0.17	NO
66	PPARGC1A	PPARGC1A	PPARGC1A	14122	-0.053	0.16	NO
67	MED16	MED16	MED16	14787	-0.066	0.13	NO
68	MED21	MED21	MED21	14797	-0.067	0.14	NO
69	MED19	MED19	MED19	14919	-0.07	0.14	NO
70	MED25	MED25	MED25	15792	-0.097	0.11	NO
71	PPARG	PPARG	PPARG	16636	-0.14	0.078	NO
72	KLF5	KLF5	KLF5	17131	-0.17	0.072	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PRKCB	PRKCB	PRKCB	15	0.83	0.074	YES
2	CD79B	CD79B	CD79B	28	0.8	0.15	YES
3	CD19	CD19	CD19	66	0.75	0.21	YES
4	CD79A	CD79A	CD79A	85	0.73	0.28	YES
5	BLK	BLK	BLK	89	0.73	0.34	YES
6	BTK	BTK	BTK	300	0.58	0.39	YES
7	PSMA8	PSMA8	PSMA8	519	0.5	0.42	YES
8	PIK3CD	PIK3CD	PIK3CD	1288	0.35	0.41	YES
9	VAV1	VAV1	VAV1	1686	0.3	0.42	YES
10	PLCG2	PLCG2	PLCG2	1979	0.27	0.42	YES
11	RASGRP3	RASGRP3	RASGRP3	2155	0.25	0.44	YES
12	FYN	FYN	FYN	2277	0.24	0.45	YES
13	REL	REL	REL	2381	0.23	0.47	YES
14	MALT1	MALT1	MALT1	3005	0.18	0.45	YES
15	RASGRP1	RASGRP1	RASGRP1	3107	0.18	0.46	YES
16	FOXO1	FOXO1	FOXO1	3117	0.18	0.48	YES
17	AKT3	AKT3	AKT3	3143	0.18	0.49	YES
18	PIK3R1	PIK3R1	PIK3R1	3665	0.15	0.48	NO
19	NR4A1	NR4A1	NR4A1	4043	0.13	0.47	NO
20	ITPR2	ITPR2	ITPR2	4194	0.12	0.47	NO
21	CBL	CBL	CBL	4321	0.12	0.47	NO
22	PLCG1	PLCG1	PLCG1	4382	0.11	0.48	NO
23	SYK	SYK	SYK	4661	0.1	0.48	NO
24	LYN	LYN	LYN	4662	0.1	0.48	NO
25	CBLB	CBLB	CBLB	5043	0.091	0.47	NO
26	PSMB9	PSMB9	PSMB9	5213	0.085	0.47	NO
27	MAP3K7	MAP3K7	MAP3K7	5286	0.083	0.48	NO
28	CDKN1B	CDKN1B	CDKN1B	5586	0.074	0.46	NO
29	GRB2	GRB2	GRB2	5637	0.073	0.47	NO
30	SH3KBP1	SH3KBP1	SH3KBP1	5693	0.071	0.47	NO
31	FOXO3	FOXO3	FOXO3	5769	0.069	0.48	NO
32	NFKBIA	NFKBIA	NFKBIA	5933	0.065	0.47	NO
33	BLNK	BLNK	BLNK	5987	0.064	0.47	NO
34	ORAI1	ORAI1	ORAI1	6075	0.062	0.48	NO
35	SOS1	SOS1	SOS1	6304	0.057	0.47	NO
36	IKBKG	IKBKG	IKBKG	6342	0.056	0.47	NO
37	PTEN	PTEN	PTEN	6359	0.055	0.48	NO
38	MTOR	MTOR	MTOR	6475	0.053	0.47	NO
39	MAPKAP1	MAPKAP1	MAPKAP1	6615	0.05	0.47	NO
40	NRAS	NRAS	NRAS	6666	0.049	0.47	NO
41	AKT2	AKT2	AKT2	7088	0.041	0.45	NO
42	SHC1	SHC1	SHC1	7113	0.041	0.46	NO
43	STIM1	STIM1	STIM1	7183	0.04	0.46	NO
44	THEM4	THEM4	THEM4	7336	0.037	0.45	NO
45	PSME4	PSME4	PSME4	7382	0.036	0.45	NO
46	PDPK1	PDPK1	PDPK1	7413	0.036	0.45	NO
47	RICTOR	RICTOR	RICTOR	7449	0.035	0.45	NO
48	CALM1	CALM1	CALM1	7462	0.035	0.46	NO
49	PSMD5	PSMD5	PSMD5	7724	0.031	0.44	NO
50	CREB1	CREB1	CREB1	7776	0.03	0.44	NO
51	CHUK	CHUK	CHUK	7788	0.03	0.45	NO
52	PSMB8	PSMB8	PSMB8	7798	0.03	0.45	NO
53	CUL1	CUL1	CUL1	7813	0.03	0.45	NO
54	PIK3AP1	PIK3AP1	PIK3AP1	8181	0.025	0.43	NO
55	NCK1	NCK1	NCK1	8765	0.018	0.4	NO
56	CDKN1A	CDKN1A	CDKN1A	8818	0.017	0.4	NO
57	PSMC2	PSMC2	PSMC2	9004	0.014	0.39	NO
58	UBA52	UBA52	UBA52	9019	0.014	0.39	NO
59	RPS27A	RPS27A	RPS27A	9064	0.014	0.39	NO
60	PSMC4	PSMC4	PSMC4	9111	0.013	0.39	NO
61	NFKBIE	NFKBIE	NFKBIE	9166	0.013	0.39	NO
62	PSMD11	PSMD11	PSMD11	9198	0.012	0.39	NO
63	PSMA1	PSMA1	PSMA1	9453	0.0091	0.38	NO
64	BTRC	BTRC	BTRC	9479	0.0087	0.38	NO
65	PSMD2	PSMD2	PSMD2	9603	0.0074	0.37	NO
66	CALM3	CALM3	CALM3	9699	0.0063	0.36	NO
67	PSMB1	PSMB1	PSMB1	9723	0.006	0.36	NO
68	CASP9	CASP9	CASP9	9764	0.0056	0.36	NO
69	PSMD7	PSMD7	PSMD7	9846	0.0047	0.36	NO
70	PSMC5	PSMC5	PSMC5	9919	0.0037	0.36	NO
71	PSMB2	PSMB2	PSMB2	10007	0.0026	0.35	NO
72	PSMA4	PSMA4	PSMA4	10034	0.0023	0.35	NO
73	PSMC1	PSMC1	PSMC1	10049	0.0021	0.35	NO
74	PSMB6	PSMB6	PSMB6	10144	0.0011	0.34	NO
75	CARD11	CARD11	CARD11	10190	0.00031	0.34	NO
76	MDM2	MDM2	MDM2	10253	-0.00038	0.34	NO
77	PSMD1	PSMD1	PSMD1	10267	-0.00062	0.34	NO
78	PSMD14	PSMD14	PSMD14	10334	-0.0012	0.33	NO
79	PSMA7	PSMA7	PSMA7	10358	-0.0015	0.33	NO
80	PSMA3	PSMA3	PSMA3	10432	-0.0025	0.33	NO
81	IKBKB	IKBKB	IKBKB	10433	-0.0025	0.33	NO
82	RPS6KB2	RPS6KB2	RPS6KB2	10492	-0.0032	0.33	NO
83	PSMC3	PSMC3	PSMC3	10778	-0.0061	0.31	NO
84	PSMD12	PSMD12	PSMD12	10810	-0.0065	0.31	NO
85	PSMD10	PSMD10	PSMD10	10820	-0.0066	0.31	NO
86	PSMA6	PSMA6	PSMA6	10958	-0.0083	0.3	NO
87	PSMD13	PSMD13	PSMD13	11051	-0.0094	0.3	NO
88	NFKBIB	NFKBIB	NFKBIB	11160	-0.011	0.3	NO
89	FBXW11	FBXW11	FBXW11	11210	-0.011	0.29	NO
90	CALM2	CALM2	CALM2	11223	-0.011	0.29	NO
91	PSMA2	PSMA2	PSMA2	11262	-0.012	0.29	NO
92	PSMA5	PSMA5	PSMA5	11294	-0.012	0.29	NO
93	RELA	RELA	RELA	11368	-0.013	0.29	NO
94	AKT1	AKT1	AKT1	11471	-0.014	0.28	NO
95	PSMD8	PSMD8	PSMD8	11503	-0.015	0.28	NO
96	PSMB3	PSMB3	PSMB3	11695	-0.017	0.28	NO
97	PSMB4	PSMB4	PSMB4	11819	-0.019	0.27	NO
98	FOXO4	FOXO4	FOXO4	11946	-0.02	0.26	NO
99	PSMC6	PSMC6	PSMC6	11954	-0.02	0.27	NO
100	PSMF1	PSMF1	PSMF1	11970	-0.02	0.27	NO
101	PSMD3	PSMD3	PSMD3	11986	-0.021	0.27	NO
102	PSMD9	PSMD9	PSMD9	12003	-0.021	0.27	NO
103	PSMB5	PSMB5	PSMB5	12193	-0.024	0.26	NO
104	SKP1	SKP1	SKP1	12318	-0.025	0.26	NO
105	KRAS	KRAS	KRAS	12329	-0.025	0.26	NO
106	PSMD6	PSMD6	PSMD6	12380	-0.026	0.26	NO
107	TSC2	TSC2	TSC2	12427	-0.027	0.26	NO
108	PSMD4	PSMD4	PSMD4	12521	-0.028	0.26	NO
109	PSMB7	PSMB7	PSMB7	12649	-0.03	0.25	NO
110	PSME1	PSME1	PSME1	12893	-0.033	0.24	NO
111	PSME2	PSME2	PSME2	13073	-0.036	0.24	NO
112	PSMB10	PSMB10	PSMB10	13216	-0.038	0.23	NO
113	AKT1S1	AKT1S1	AKT1S1	13279	-0.039	0.23	NO
114	ITPR3	ITPR3	ITPR3	13384	-0.041	0.23	NO
115	BCL10	BCL10	BCL10	13421	-0.041	0.23	NO
116	GSK3A	GSK3A	GSK3A	13552	-0.043	0.23	NO
117	PHLPP1	PHLPP1	PHLPP1	14183	-0.054	0.2	NO
118	MLST8	MLST8	MLST8	14428	-0.059	0.19	NO
119	BAD	BAD	BAD	15149	-0.076	0.16	NO
120	HRAS	HRAS	HRAS	15336	-0.081	0.16	NO
121	TRIB3	TRIB3	TRIB3	17025	-0.16	0.078	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Methods & Data

Made with Nozzle

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	BLK	BLK	BLK	89	0.73	0.051	YES
2	MYOCD	MYOCD	MYOCD	456	0.52	0.072	YES
3	PIK3R5	PIK3R5	PIK3R5	601	0.48	0.1	YES
4	PIK3CG	PIK3CG	PIK3CG	646	0.47	0.13	YES
5	SLA	SLA	SLA	939	0.42	0.15	YES
6	LCK	LCK	LCK	951	0.41	0.18	YES
7	PIK3R6	PIK3R6	PIK3R6	975	0.41	0.21	YES
8	S1PR1	S1PR1	S1PR1	1249	0.36	0.22	YES
9	FGR	FGR	FGR	1275	0.36	0.25	YES
10	PIK3CD	PIK3CD	PIK3CD	1288	0.35	0.28	YES
11	ITGB3	ITGB3	ITGB3	1650	0.3	0.28	YES
12	HCK	HCK	HCK	1771	0.29	0.3	YES
13	MAPK10	MAPK10	MAPK10	1784	0.29	0.32	YES
14	FYN	FYN	FYN	2277	0.24	0.31	YES
15	CYFIP2	CYFIP2	CYFIP2	2422	0.23	0.32	YES
16	TAGLN	TAGLN	TAGLN	2718	0.21	0.32	YES
17	PAG1	PAG1	PAG1	2851	0.2	0.33	YES
18	ACTA2	ACTA2	ACTA2	3066	0.18	0.33	YES
19	DOCK4	DOCK4	DOCK4	3075	0.18	0.34	YES
20	PIK3R3	PIK3R3	PIK3R3	3095	0.18	0.36	YES
21	PPP2R2B	PPP2R2B	PPP2R2B	3391	0.16	0.35	YES
22	JAK2	JAK2	JAK2	3442	0.16	0.36	YES
23	SIPA1	SIPA1	SIPA1	3559	0.15	0.37	YES
24	PIK3R1	PIK3R1	PIK3R1	3665	0.15	0.37	YES
25	STAT5A	STAT5A	STAT5A	3679	0.15	0.38	YES
26	MYC	MYC	MYC	4023	0.13	0.37	YES
27	RAPGEF1	RAPGEF1	RAPGEF1	4053	0.13	0.38	YES
28	RAP1A	RAP1A	RAP1A	4170	0.12	0.38	YES
29	LRP1	LRP1	LRP1	4205	0.12	0.39	YES
30	ABL1	ABL1	ABL1	4232	0.12	0.4	YES
31	STAT5B	STAT5B	STAT5B	4237	0.12	0.41	YES
32	SRF	SRF	SRF	4316	0.12	0.41	YES
33	CBL	CBL	CBL	4321	0.12	0.42	YES
34	PLCG1	PLCG1	PLCG1	4382	0.11	0.43	YES
35	PDGFRB	PDGFRB	PDGFRB	4426	0.11	0.43	YES
36	CSK	CSK	CSK	4562	0.11	0.44	YES
37	PIK3CA	PIK3CA	PIK3CA	4566	0.11	0.44	YES
38	SPHK1	SPHK1	SPHK1	4572	0.11	0.45	YES
39	KSR1	KSR1	KSR1	4610	0.1	0.46	YES
40	PTPN1	PTPN1	PTPN1	4631	0.1	0.46	YES
41	LYN	LYN	LYN	4662	0.1	0.47	YES
42	WASF2	WASF2	WASF2	4822	0.098	0.47	YES
43	GAB1	GAB1	GAB1	4878	0.096	0.47	YES
44	DOK1	DOK1	DOK1	5240	0.084	0.46	NO
45	PRKCE	PRKCE	PRKCE	5301	0.082	0.46	NO
46	GRB2	GRB2	GRB2	5637	0.073	0.45	NO
47	MAP2K4	MAP2K4	MAP2K4	5776	0.069	0.45	NO
48	CRK	CRK	CRK	5971	0.064	0.44	NO
49	ITGAV	ITGAV	ITGAV	6018	0.063	0.44	NO
50	PDGFB	PDGFB	PDGFB	6113	0.061	0.44	NO
51	ARAP1	ARAP1	ARAP1	6220	0.059	0.44	NO
52	ACTR2	ACTR2	ACTR2	6302	0.057	0.44	NO
53	SOS1	SOS1	SOS1	6304	0.057	0.45	NO
54	ELK1	ELK1	ELK1	6322	0.056	0.45	NO
55	STAT3	STAT3	STAT3	6325	0.056	0.46	NO
56	RAP1B	RAP1B	RAP1B	6335	0.056	0.46	NO
57	PTEN	PTEN	PTEN	6359	0.055	0.46	NO
58	ACTR3	ACTR3	ACTR3	6368	0.055	0.47	NO
59	STAT1	STAT1	STAT1	6391	0.055	0.47	NO
60	NRAS	NRAS	NRAS	6666	0.049	0.46	NO
61	MAPK1	MAPK1	MAPK1	6760	0.048	0.46	NO
62	PTPN11	PTPN11	PTPN11	6857	0.046	0.46	NO
63	SHC1	SHC1	SHC1	7113	0.041	0.44	NO
64	ARPC2	ARPC2	ARPC2	7180	0.04	0.44	NO
65	RPS6KA3	RPS6KA3	RPS6KA3	7475	0.035	0.43	NO
66	MAP2K1	MAP2K1	MAP2K1	7825	0.03	0.41	NO
67	ARPC1B	ARPC1B	ARPC1B	7924	0.028	0.41	NO
68	MAPK8	MAPK8	MAPK8	8009	0.027	0.41	NO
69	RHOA	RHOA	RHOA	8044	0.026	0.41	NO
70	JUN	JUN	JUN	8203	0.024	0.4	NO
71	ARPC4	ARPC4	ARPC4	8661	0.019	0.38	NO
72	NCK1	NCK1	NCK1	8765	0.018	0.37	NO
73	RAF1	RAF1	RAF1	8915	0.016	0.37	NO
74	ABI1	ABI1	ABI1	8982	0.015	0.36	NO
75	YWHAB	YWHAB	YWHAB	9231	0.012	0.35	NO
76	YWHAQ	YWHAQ	YWHAQ	9301	0.011	0.35	NO
77	IQGAP1	IQGAP1	IQGAP1	9331	0.011	0.35	NO
78	USP6NL	USP6NL	USP6NL	9446	0.0091	0.34	NO
79	ARPC5	ARPC5	ARPC5	9733	0.0059	0.33	NO
80	YWHAG	YWHAG	YWHAG	9865	0.0044	0.32	NO
81	NCK2	NCK2	NCK2	10153	0.001	0.3	NO
82	JUND	JUND	JUND	10350	-0.0014	0.29	NO
83	FOS	FOS	FOS	10406	-0.002	0.29	NO
84	PRKCA	PRKCA	PRKCA	10424	-0.0024	0.29	NO
85	YWHAH	YWHAH	YWHAH	10537	-0.0036	0.28	NO
86	ARPC3	ARPC3	ARPC3	10915	-0.0078	0.26	NO
87	PPP2CA	PPP2CA	PPP2CA	10982	-0.0085	0.26	NO
88	PTPRJ	PTPRJ	PTPRJ	10991	-0.0086	0.26	NO
89	BRAF	BRAF	BRAF	11009	-0.0088	0.26	NO
90	ARHGDIA	ARHGDIA	ARHGDIA	11338	-0.013	0.24	NO
91	MAPK9	MAPK9	MAPK9	11534	-0.015	0.24	NO
92	PTPN2	PTPN2	PTPN2	11642	-0.016	0.23	NO
93	EIF2AK2	EIF2AK2	EIF2AK2	12043	-0.022	0.21	NO
94	PIN1	PIN1	PIN1	12148	-0.023	0.21	NO
95	GRB10	GRB10	GRB10	12172	-0.023	0.21	NO
96	EPS8	EPS8	EPS8	12191	-0.023	0.21	NO
97	RAB5A	RAB5A	RAB5A	12258	-0.024	0.21	NO
98	KRAS	KRAS	KRAS	12329	-0.025	0.2	NO
99	NCKAP1	NCKAP1	NCKAP1	12462	-0.028	0.2	NO
100	YWHAE	YWHAE	YWHAE	12536	-0.028	0.2	NO
101	RASA1	RASA1	RASA1	12790	-0.032	0.19	NO
102	ACTN4	ACTN4	ACTN4	12818	-0.032	0.19	NO
103	PPP2R1A	PPP2R1A	PPP2R1A	12853	-0.033	0.19	NO
104	YWHAZ	YWHAZ	YWHAZ	12968	-0.034	0.18	NO
105	MAP2K7	MAP2K7	MAP2K7	13008	-0.035	0.18	NO
106	PIK3R2	PIK3R2	PIK3R2	13595	-0.044	0.16	NO
107	PLA2G4A	PLA2G4A	PLA2G4A	13643	-0.045	0.16	NO
108	MAP2K2	MAP2K2	MAP2K2	13732	-0.046	0.16	NO
109	MAPK3	MAPK3	MAPK3	13954	-0.05	0.15	NO
110	DNM2	DNM2	DNM2	13970	-0.05	0.15	NO
111	RAB4A	RAB4A	RAB4A	14030	-0.051	0.15	NO
112	PIK3CB	PIK3CB	PIK3CB	14087	-0.053	0.15	NO
113	CTTN	CTTN	CTTN	14118	-0.053	0.16	NO
114	YES1	YES1	YES1	14159	-0.054	0.16	NO
115	MLLT4	MLLT4	MLLT4	14249	-0.056	0.16	NO
116	RAC1	RAC1	RAC1	14257	-0.056	0.16	NO
117	VAV2	VAV2	VAV2	14315	-0.057	0.16	NO
118	PRKCD	PRKCD	PRKCD	14668	-0.064	0.15	NO
119	BAIAP2	BAIAP2	BAIAP2	14695	-0.064	0.15	NO
120	WASL	WASL	WASL	14725	-0.065	0.15	NO
121	HRAS	HRAS	HRAS	15336	-0.081	0.13	NO
122	BCAR1	BCAR1	BCAR1	15338	-0.081	0.13	NO
123	SLC9A3R2	SLC9A3R2	SLC9A3R2	15395	-0.083	0.14	NO
124	SRC	SRC	SRC	15811	-0.098	0.12	NO
125	PAK1	PAK1	PAK1	15818	-0.098	0.13	NO
126	SFN	SFN	SFN	15853	-0.099	0.13	NO
127	SLC9A3R1	SLC9A3R1	SLC9A3R1	15897	-0.1	0.14	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ACAP1	ACAP1	ACAP1	219	0.62	0.064	YES
2	SLC2A4	SLC2A4	SLC2A4	241	0.61	0.14	YES
3	ITGA8	ITGA8	ITGA8	251	0.6	0.21	YES
4	IL2RA	IL2RA	IL2RA	513	0.5	0.26	YES
5	ADRB2	ADRB2	ADRB2	563	0.49	0.32	YES
6	TSHR	TSHR	TSHR	651	0.47	0.37	YES
7	ITGA4	ITGA4	ITGA4	738	0.45	0.42	YES
8	AGTR1	AGTR1	AGTR1	773	0.44	0.47	YES
9	ITGA9	ITGA9	ITGA9	886	0.43	0.52	YES
10	AVPR2	AVPR2	AVPR2	911	0.42	0.57	YES
11	ITGA7	ITGA7	ITGA7	927	0.42	0.62	YES
12	EDNRB	EDNRB	EDNRB	1158	0.37	0.65	YES
13	ITGA5	ITGA5	ITGA5	3199	0.17	0.56	NO
14	ITGA11	ITGA11	ITGA11	3666	0.15	0.55	NO
15	ITGA1	ITGA1	ITGA1	3674	0.15	0.57	NO
16	ITGA10	ITGA10	ITGA10	4073	0.13	0.56	NO
17	BIN1	BIN1	BIN1	5191	0.086	0.51	NO
18	EXOC2	EXOC2	EXOC2	5791	0.069	0.49	NO
19	ITGAV	ITGAV	ITGAV	6018	0.063	0.49	NO
20	EXOC5	EXOC5	EXOC5	6057	0.062	0.49	NO
21	SPAG9	SPAG9	SPAG9	6298	0.057	0.48	NO
22	CPE	CPE	CPE	7002	0.043	0.45	NO
23	PIP5K1C	PIP5K1C	PIP5K1C	7422	0.036	0.43	NO
24	KLC1	KLC1	KLC1	8305	0.023	0.39	NO
25	ITGB1	ITGB1	ITGB1	8861	0.016	0.36	NO
26	VAMP3	VAMP3	VAMP3	9010	0.014	0.35	NO
27	PLD2	PLD2	PLD2	9273	0.012	0.34	NO
28	CLTC	CLTC	CLTC	9478	0.0087	0.33	NO
29	CTNNB1	CTNNB1	CTNNB1	10027	0.0024	0.3	NO
30	ARF6	ARF6	ARF6	10206	0.000091	0.29	NO
31	EXOC3	EXOC3	EXOC3	10652	-0.0049	0.27	NO
32	EXOC7	EXOC7	EXOC7	10738	-0.0057	0.26	NO
33	RALA	RALA	RALA	11202	-0.011	0.24	NO
34	EXOC1	EXOC1	EXOC1	11486	-0.015	0.23	NO
35	SCAMP2	SCAMP2	SCAMP2	12551	-0.028	0.17	NO
36	EXOC6	EXOC6	EXOC6	12787	-0.032	0.16	NO
37	MAPK8IP3	MAPK8IP3	MAPK8IP3	13428	-0.042	0.14	NO
38	NME1	NME1	NME1	13661	-0.045	0.13	NO
39	EXOC4	EXOC4	EXOC4	13714	-0.046	0.13	NO
40	CTNNA1	CTNNA1	CTNNA1	13909	-0.049	0.13	NO
41	DNM2	DNM2	DNM2	13970	-0.05	0.13	NO
42	ITGA6	ITGA6	ITGA6	15136	-0.076	0.075	NO
43	PLD1	PLD1	PLD1	15247	-0.079	0.078	NO
44	CTNND1	CTNND1	CTNND1	15597	-0.09	0.07	NO
45	ASAP2	ASAP2	ASAP2	16053	-0.11	0.059	NO
46	INS	INS	INS	16363	-0.12	0.057	NO
47	ITGA2	ITGA2	ITGA2	16476	-0.13	0.066	NO
48	ITGA3	ITGA3	ITGA3	17082	-0.17	0.054	NO
49	CDH1	CDH1	CDH1	17168	-0.17	0.07	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NTRK3	NTRK3	NTRK3	117	0.7	0.044	YES
2	NGF	NGF	NGF	287	0.59	0.078	YES
3	CAMK2A	CAMK2A	CAMK2A	330	0.57	0.12	YES
4	NGFR	NGFR	NGFR	482	0.51	0.14	YES
5	FASLG	FASLG	FASLG	493	0.51	0.18	YES
6	PIK3R5	PIK3R5	PIK3R5	601	0.48	0.21	YES
7	PIK3CG	PIK3CG	PIK3CG	646	0.47	0.24	YES
8	CAMK4	CAMK4	CAMK4	767	0.44	0.27	YES
9	BCL2	BCL2	BCL2	824	0.44	0.3	YES
10	SHC4	SHC4	SHC4	826	0.44	0.33	YES
11	PIK3CD	PIK3CD	PIK3CD	1288	0.35	0.33	YES
12	NTRK1	NTRK1	NTRK1	1397	0.34	0.35	YES
13	MAPK10	MAPK10	MAPK10	1784	0.29	0.35	YES
14	RPS6KA5	RPS6KA5	RPS6KA5	1839	0.28	0.36	YES
15	PLCG2	PLCG2	PLCG2	1979	0.27	0.38	YES
16	NTF3	NTF3	NTF3	2349	0.24	0.37	YES
17	SH2B2	SH2B2	SH2B2	2596	0.22	0.38	YES
18	MAPK11	MAPK11	MAPK11	2800	0.2	0.38	YES
19	MAP3K3	MAP3K3	MAP3K3	3041	0.18	0.38	YES
20	PIK3R3	PIK3R3	PIK3R3	3095	0.18	0.39	YES
21	ARHGDIB	ARHGDIB	ARHGDIB	3119	0.18	0.4	YES
22	SH2B3	SH2B3	SH2B3	3131	0.18	0.41	YES
23	AKT3	AKT3	AKT3	3143	0.18	0.42	YES
24	NTRK2	NTRK2	NTRK2	3150	0.18	0.44	YES
25	MAPK12	MAPK12	MAPK12	3158	0.18	0.45	YES
26	IRAK3	IRAK3	IRAK3	3440	0.16	0.45	NO
27	PIK3R1	PIK3R1	PIK3R1	3665	0.15	0.44	NO
28	RAPGEF1	RAPGEF1	RAPGEF1	4053	0.13	0.43	NO
29	RAP1A	RAP1A	RAP1A	4170	0.12	0.44	NO
30	ABL1	ABL1	ABL1	4232	0.12	0.44	NO
31	PLCG1	PLCG1	PLCG1	4382	0.11	0.44	NO
32	CSK	CSK	CSK	4562	0.11	0.44	NO
33	PIK3CA	PIK3CA	PIK3CA	4566	0.11	0.45	NO
34	GAB1	GAB1	GAB1	4878	0.096	0.44	NO
35	BDNF	BDNF	BDNF	4917	0.095	0.44	NO
36	IRAK4	IRAK4	IRAK4	5169	0.086	0.43	NO
37	GRB2	GRB2	GRB2	5637	0.073	0.41	NO
38	FOXO3	FOXO3	FOXO3	5769	0.069	0.41	NO
39	NFKBIA	NFKBIA	NFKBIA	5933	0.065	0.41	NO
40	CRK	CRK	CRK	5971	0.064	0.41	NO
41	PDK1	PDK1	PDK1	6033	0.063	0.41	NO
42	MAPK7	MAPK7	MAPK7	6234	0.058	0.4	NO
43	SOS1	SOS1	SOS1	6304	0.057	0.4	NO
44	NFKB1	NFKB1	NFKB1	6320	0.056	0.41	NO
45	RAP1B	RAP1B	RAP1B	6335	0.056	0.41	NO
46	MAP3K1	MAP3K1	MAP3K1	6339	0.056	0.42	NO
47	TP53	TP53	TP53	6618	0.05	0.4	NO
48	NRAS	NRAS	NRAS	6666	0.049	0.4	NO
49	MAPK1	MAPK1	MAPK1	6760	0.048	0.4	NO
50	RPS6KA6	RPS6KA6	RPS6KA6	6794	0.047	0.4	NO
51	PTPN11	PTPN11	PTPN11	6857	0.046	0.4	NO
52	RPS6KA2	RPS6KA2	RPS6KA2	6858	0.046	0.41	NO
53	TRAF6	TRAF6	TRAF6	6878	0.045	0.41	NO
54	CAMK2G	CAMK2G	CAMK2G	6893	0.045	0.41	NO
55	FRS2	FRS2	FRS2	6932	0.044	0.41	NO
56	PRDM4	PRDM4	PRDM4	7012	0.043	0.41	NO
57	MAPKAPK2	MAPKAPK2	MAPKAPK2	7057	0.042	0.41	NO
58	AKT2	AKT2	AKT2	7088	0.041	0.41	NO
59	SHC1	SHC1	SHC1	7113	0.041	0.42	NO
60	MAPK14	MAPK14	MAPK14	7186	0.039	0.42	NO
61	MAP2K5	MAP2K5	MAP2K5	7204	0.039	0.42	NO
62	KIDINS220	KIDINS220	KIDINS220	7247	0.038	0.42	NO
63	CRKL	CRKL	CRKL	7369	0.036	0.41	NO
64	CALM1	CALM1	CALM1	7462	0.035	0.41	NO
65	RPS6KA3	RPS6KA3	RPS6KA3	7475	0.035	0.41	NO
66	CAMK2D	CAMK2D	CAMK2D	7560	0.034	0.41	NO
67	CDC42	CDC42	CDC42	7621	0.032	0.41	NO
68	MAP2K1	MAP2K1	MAP2K1	7825	0.03	0.4	NO
69	MAPK8	MAPK8	MAPK8	8009	0.027	0.39	NO
70	RHOA	RHOA	RHOA	8044	0.026	0.39	NO
71	SOS2	SOS2	SOS2	8100	0.026	0.39	NO
72	JUN	JUN	JUN	8203	0.024	0.39	NO
73	RIPK2	RIPK2	RIPK2	8274	0.024	0.39	NO
74	IRS2	IRS2	IRS2	8551	0.02	0.37	NO
75	RPS6KA1	RPS6KA1	RPS6KA1	8864	0.016	0.36	NO
76	RAF1	RAF1	RAF1	8915	0.016	0.36	NO
77	NFKBIE	NFKBIE	NFKBIE	9166	0.013	0.34	NO
78	YWHAB	YWHAB	YWHAB	9231	0.012	0.34	NO
79	YWHAQ	YWHAQ	YWHAQ	9301	0.011	0.34	NO
80	CALM3	CALM3	CALM3	9699	0.0063	0.32	NO
81	MAGED1	MAGED1	MAGED1	9831	0.0049	0.31	NO
82	YWHAG	YWHAG	YWHAG	9865	0.0044	0.31	NO
83	ZNF274	ZNF274	ZNF274	9904	0.004	0.3	NO
84	IKBKB	IKBKB	IKBKB	10433	-0.0025	0.28	NO
85	GSK3B	GSK3B	GSK3B	10472	-0.003	0.28	NO
86	YWHAH	YWHAH	YWHAH	10537	-0.0036	0.27	NO
87	CALML5	CALML5	CALML5	10748	-0.0058	0.26	NO
88	ATF4	ATF4	ATF4	10955	-0.0082	0.25	NO
89	BRAF	BRAF	BRAF	11009	-0.0088	0.25	NO
90	IRS1	IRS1	IRS1	11125	-0.01	0.24	NO
91	NFKBIB	NFKBIB	NFKBIB	11160	-0.011	0.24	NO
92	CALM2	CALM2	CALM2	11223	-0.011	0.24	NO
93	ARHGDIA	ARHGDIA	ARHGDIA	11338	-0.013	0.23	NO
94	IRAK1	IRAK1	IRAK1	11360	-0.013	0.23	NO
95	RELA	RELA	RELA	11368	-0.013	0.23	NO
96	AKT1	AKT1	AKT1	11471	-0.014	0.23	NO
97	MAPK9	MAPK9	MAPK9	11534	-0.015	0.23	NO
98	NGFRAP1	NGFRAP1	NGFRAP1	11568	-0.015	0.23	NO
99	SORT1	SORT1	SORT1	11681	-0.017	0.22	NO
100	BAX	BAX	BAX	12198	-0.024	0.2	NO
101	KRAS	KRAS	KRAS	12329	-0.025	0.19	NO
102	SH2B1	SH2B1	SH2B1	12361	-0.026	0.19	NO
103	RPS6KA4	RPS6KA4	RPS6KA4	12461	-0.027	0.19	NO
104	YWHAE	YWHAE	YWHAE	12536	-0.028	0.18	NO
105	YWHAZ	YWHAZ	YWHAZ	12968	-0.034	0.16	NO
106	MAP2K7	MAP2K7	MAP2K7	13008	-0.035	0.16	NO
107	MAP3K5	MAP3K5	MAP3K5	13086	-0.036	0.16	NO
108	CAMK2B	CAMK2B	CAMK2B	13138	-0.037	0.16	NO
109	PSEN1	PSEN1	PSEN1	13331	-0.04	0.15	NO
110	PIK3R2	PIK3R2	PIK3R2	13595	-0.044	0.14	NO
111	MAP2K2	MAP2K2	MAP2K2	13732	-0.046	0.14	NO
112	IRAK2	IRAK2	IRAK2	13762	-0.047	0.14	NO
113	MAPK3	MAPK3	MAPK3	13954	-0.05	0.13	NO
114	PIK3CB	PIK3CB	PIK3CB	14087	-0.053	0.13	NO
115	RAC1	RAC1	RAC1	14257	-0.056	0.12	NO
116	CALML3	CALML3	CALML3	14663	-0.064	0.11	NO
117	PRKCD	PRKCD	PRKCD	14668	-0.064	0.11	NO
118	BAD	BAD	BAD	15149	-0.076	0.092	NO
119	HRAS	HRAS	HRAS	15336	-0.081	0.087	NO
120	TP73	TP73	TP73	15409	-0.084	0.09	NO
121	IRS4	IRS4	IRS4	15884	-0.1	0.071	NO
122	MAPK13	MAPK13	MAPK13	16305	-0.12	0.056	NO
123	CALML6	CALML6	CALML6	16403	-0.12	0.06	NO
124	SHC2	SHC2	SHC2	17019	-0.16	0.038	NO
125	SHC3	SHC3	SHC3	17492	-0.2	0.027	NO
126	NTF4	NTF4	NTF4	18335	-0.35	0.0067	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	BTK	BTK	BTK	300	0.58	0.064	YES
2	TLR6	TLR6	TLR6	653	0.47	0.11	YES
3	S100A12	S100A12	S100A12	793	0.44	0.16	YES
4	LY96	LY96	LY96	1091	0.39	0.2	YES
5	S100B	S100B	S100B	1308	0.35	0.24	YES
6	MEF2C	MEF2C	MEF2C	1509	0.32	0.27	YES
7	SAA1	SAA1	SAA1	1515	0.32	0.31	YES
8	MAPK10	MAPK10	MAPK10	1784	0.29	0.34	YES
9	RPS6KA5	RPS6KA5	RPS6KA5	1839	0.28	0.37	YES
10	TLR4	TLR4	TLR4	2013	0.26	0.4	YES
11	MAPK11	MAPK11	MAPK11	2800	0.2	0.38	YES
12	TLR1	TLR1	TLR1	3234	0.17	0.38	YES
13	NOD1	NOD1	NOD1	3323	0.17	0.4	YES
14	NOD2	NOD2	NOD2	3436	0.16	0.42	YES
15	IRAK3	IRAK3	IRAK3	3440	0.16	0.44	YES
16	AGER	AGER	AGER	3558	0.15	0.45	YES
17	TLR2	TLR2	TLR2	3650	0.15	0.47	YES
18	MEF2A	MEF2A	MEF2A	5120	0.088	0.4	NO
19	IRAK4	IRAK4	IRAK4	5169	0.086	0.41	NO
20	MAP3K7	MAP3K7	MAP3K7	5286	0.083	0.42	NO
21	TMEM189-UBE2V1	TMEM189-UBE2V1	TMEM189-UBE2V1	5410	0.079	0.42	NO
22	MAP2K4	MAP2K4	MAP2K4	5776	0.069	0.41	NO
23	NFKBIA	NFKBIA	NFKBIA	5933	0.065	0.41	NO
24	TAB2	TAB2	TAB2	5994	0.064	0.42	NO
25	MAPK7	MAPK7	MAPK7	6234	0.058	0.41	NO
26	ELK1	ELK1	ELK1	6322	0.056	0.41	NO
27	MAP3K1	MAP3K1	MAP3K1	6339	0.056	0.42	NO
28	IKBKG	IKBKG	IKBKG	6342	0.056	0.43	NO
29	ATF2	ATF2	ATF2	6738	0.048	0.41	NO
30	MAPK1	MAPK1	MAPK1	6760	0.048	0.42	NO
31	RPS6KA2	RPS6KA2	RPS6KA2	6858	0.046	0.42	NO
32	TRAF6	TRAF6	TRAF6	6878	0.045	0.42	NO
33	DUSP3	DUSP3	DUSP3	6978	0.043	0.42	NO
34	PELI2	PELI2	PELI2	6986	0.043	0.43	NO
35	MAPKAPK2	MAPKAPK2	MAPKAPK2	7057	0.042	0.43	NO
36	MAPK14	MAPK14	MAPK14	7186	0.039	0.43	NO
37	NFKB2	NFKB2	NFKB2	7352	0.036	0.43	NO
38	RPS6KA3	RPS6KA3	RPS6KA3	7475	0.035	0.43	NO
39	ATF1	ATF1	ATF1	7499	0.034	0.43	NO
40	UBE2N	UBE2N	UBE2N	7537	0.034	0.43	NO
41	CREB1	CREB1	CREB1	7776	0.03	0.42	NO
42	CHUK	CHUK	CHUK	7788	0.03	0.43	NO
43	MAP2K1	MAP2K1	MAP2K1	7825	0.03	0.43	NO
44	MAPK8	MAPK8	MAPK8	8009	0.027	0.42	NO
45	JUN	JUN	JUN	8203	0.024	0.42	NO
46	RIPK2	RIPK2	RIPK2	8274	0.024	0.42	NO
47	PELI1	PELI1	PELI1	8393	0.022	0.41	NO
48	PPP2R5D	PPP2R5D	PPP2R5D	8425	0.022	0.41	NO
49	MAP2K6	MAP2K6	MAP2K6	8745	0.018	0.4	NO
50	RPS6KA1	RPS6KA1	RPS6KA1	8864	0.016	0.39	NO
51	HMGB1	HMGB1	HMGB1	8968	0.015	0.39	NO
52	UBA52	UBA52	UBA52	9019	0.014	0.39	NO
53	DUSP7	DUSP7	DUSP7	9062	0.014	0.39	NO
54	RPS27A	RPS27A	RPS27A	9064	0.014	0.39	NO
55	MYD88	MYD88	MYD88	9357	0.01	0.38	NO
56	PELI3	PELI3	PELI3	9551	0.0079	0.37	NO
57	TAB1	TAB1	TAB1	10204	0.00013	0.33	NO
58	FOS	FOS	FOS	10406	-0.002	0.32	NO
59	IKBKB	IKBKB	IKBKB	10433	-0.0025	0.32	NO
60	PPP2CA	PPP2CA	PPP2CA	10982	-0.0085	0.29	NO
61	TIRAP	TIRAP	TIRAP	11064	-0.0096	0.29	NO
62	NFKBIB	NFKBIB	NFKBIB	11160	-0.011	0.28	NO
63	MAPKAPK3	MAPKAPK3	MAPKAPK3	11355	-0.013	0.28	NO
64	IRAK1	IRAK1	IRAK1	11360	-0.013	0.28	NO
65	RELA	RELA	RELA	11368	-0.013	0.28	NO
66	MAPK9	MAPK9	MAPK9	11534	-0.015	0.27	NO
67	MAP2K3	MAP2K3	MAP2K3	11658	-0.017	0.27	NO
68	PPP2CB	PPP2CB	PPP2CB	11691	-0.017	0.27	NO
69	APP	APP	APP	12038	-0.022	0.25	NO
70	PPP2R1B	PPP2R1B	PPP2R1B	12210	-0.024	0.25	NO
71	TAB3	TAB3	TAB3	12391	-0.026	0.24	NO
72	CDK1	CDK1	CDK1	12606	-0.029	0.23	NO
73	PPP2R1A	PPP2R1A	PPP2R1A	12853	-0.033	0.22	NO
74	MAP2K7	MAP2K7	MAP2K7	13008	-0.035	0.22	NO
75	MAP2K2	MAP2K2	MAP2K2	13732	-0.046	0.19	NO
76	IRAK2	IRAK2	IRAK2	13762	-0.047	0.19	NO
77	MAPK3	MAPK3	MAPK3	13954	-0.05	0.19	NO
78	DUSP6	DUSP6	DUSP6	14667	-0.064	0.16	NO
79	ECSIT	ECSIT	ECSIT	14937	-0.071	0.15	NO
80	SIGIRR	SIGIRR	SIGIRR	15862	-0.099	0.12	NO
81	DUSP4	DUSP4	DUSP4	17300	-0.18	0.063	NO