GSEA Class2: Canonical Pathways enriched in each subtypes of mRNAseq_cNMF in STES-TP - Stomach and Esophageal carcinoma (Primary solid tumor)

basic data info
Number of Gene Sets: 726
Number of samples: 599
Original number of Gene Sets: 1320
Maximum gene set size: 933

phenotype info
pheno.type: 1 - 3 :[ clus1 ] 170
pheno.type: 2 - 3 :[ clus2 ] 275
pheno.type: 3 - 3 :[ clus3 ] 154

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
PID P73PATHWAY	79	genes.ES.table	0.46	1.8	0.012	0.35	0.65	0.15	0.095	0.14	0.096	0.089
PID MTOR 4PATHWAY	67	genes.ES.table	0.44	2.1	0.0041	0.21	0.1	0.54	0.34	0.36	0	0.057
PID MYC PATHWAY	25	genes.ES.table	0.43	1.6	0.03	0.48	0.91	0.6	0.35	0.39	0.23	0.13
PID DELTANP63PATHWAY	47	genes.ES.table	0.67	2	0	0.22	0.27	0.45	0.18	0.37	0	0.045
PID AURORA A PATHWAY	31	genes.ES.table	0.53	1.8	0.032	0.36	0.63	0.48	0.27	0.36	0.095	0.09
PID TAP63PATHWAY	54	genes.ES.table	0.49	1.7	0.0098	0.47	0.88	0.2	0.096	0.18	0.2	0.13
PID P53REGULATIONPATHWAY	58	genes.ES.table	0.35	1.6	0.062	0.51	0.91	0.31	0.28	0.22	0.24	0.14
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	38	genes.ES.table	0.49	1.8	0.0061	0.3	0.54	0.1	0.041	0.1	0.072	0.076
REACTOME MEMBRANE TRAFFICKING	124	genes.ES.table	0.36	2	0	0.21	0.2	0.081	0.038	0.078	0	0.046
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	65	genes.ES.table	0.4	1.6	0.061	0.52	0.91	0.63	0.37	0.4	0.24	0.14

genes ES table in pathway: PID P73PATHWAY

Table S1. Get Full Table This table shows a Running Enrichment Score (RES) of each gene in this pathway, that is, the enrichment score at this point in the ranked list of genes. All genes are ranked by Signal-to-Noise (S2N), a measure of similarity as default and are used to obtain ES matrix of all genes. In this way, GSEA tool uses expression pattern of not only overlapped genes but also not-overlapped genes to produce ES matrix.

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SFN	SFN	SFN	320	0.56	0.078	YES
2	BNIP3	BNIP3	BNIP3	500	0.46	0.15	YES
3	SGK1	SGK1	SGK1	1285	0.25	0.15	YES
4	HRAS	HRAS	HRAS	1461	0.23	0.18	YES
5	ULK2	ULK2	ULK2	1697	0.2	0.2	YES
6	PLD2	PLD2	PLD2	1701	0.2	0.23	YES
7	ULK1	ULK1	ULK1	1706	0.2	0.27	YES
8	RRAGD	RRAGD	RRAGD	1752	0.2	0.3	YES
9	PLD1	PLD1	PLD1	1801	0.19	0.33	YES
10	CLIP1	CLIP1	CLIP1	2131	0.17	0.34	YES
11	EIF4EBP1	EIF4EBP1	EIF4EBP1	2419	0.15	0.35	YES
12	SREBF1	SREBF1	SREBF1	2970	0.12	0.34	YES
13	YWHAQ	YWHAQ	YWHAQ	3107	0.11	0.35	YES
14	RRAGC	RRAGC	RRAGC	3218	0.11	0.37	YES
15	RB1CC1	RB1CC1	RB1CC1	3385	0.1	0.38	YES
16	DDIT4	DDIT4	DDIT4	3476	0.1	0.39	YES
17	BRAF	BRAF	BRAF	3838	0.089	0.38	YES
18	CCNE1	CCNE1	CCNE1	3935	0.086	0.39	YES
19	YWHAG	YWHAG	YWHAG	4068	0.082	0.4	YES
20	MAP2K1	MAP2K1	MAP2K1	4101	0.081	0.41	YES
21	RICTOR	RICTOR	RICTOR	4192	0.079	0.42	YES
22	YWHAZ	YWHAZ	YWHAZ	4310	0.076	0.43	YES
23	RPS6KB1	RPS6KB1	RPS6KB1	4351	0.074	0.44	YES
24	PML	PML	PML	4580	0.07	0.44	YES
25	IRS1	IRS1	IRS1	5183	0.057	0.42	YES
26	YY1	YY1	YY1	5218	0.056	0.42	YES
27	YWHAE	YWHAE	YWHAE	5219	0.056	0.43	YES
28	NRAS	NRAS	NRAS	5558	0.05	0.42	YES
29	MAPK1	MAPK1	MAPK1	5571	0.05	0.43	YES
30	EIF4A1	EIF4A1	EIF4A1	5590	0.05	0.44	YES
31	POLDIP3	POLDIP3	POLDIP3	5660	0.048	0.44	YES
32	RPTOR	RPTOR	RPTOR	5913	0.044	0.44	YES
33	EIF4E	EIF4E	EIF4E	5968	0.043	0.44	YES
34	MTOR	MTOR	MTOR	6160	0.04	0.44	YES
35	TSC1	TSC1	TSC1	6253	0.038	0.44	YES
36	IKBKB	IKBKB	IKBKB	6285	0.038	0.44	YES
37	PDCD4	PDCD4	PDCD4	6579	0.033	0.44	NO
38	PXN	PXN	PXN	6796	0.03	0.43	NO
39	CDK2	CDK2	CDK2	6985	0.027	0.42	NO
40	RAF1	RAF1	RAF1	7089	0.026	0.42	NO
41	RHEB	RHEB	RHEB	7143	0.025	0.42	NO
42	TSC2	TSC2	TSC2	7359	0.022	0.42	NO
43	RAC1	RAC1	RAC1	7739	0.017	0.4	NO
44	RRAGA	RRAGA	RRAGA	7890	0.015	0.39	NO
45	RRN3	RRN3	RRN3	7997	0.014	0.39	NO
46	MAP2K2	MAP2K2	MAP2K2	8119	0.012	0.38	NO
47	MAPKAP1	MAPKAP1	MAPKAP1	8177	0.011	0.38	NO
48	EEF2K	EEF2K	EEF2K	8498	0.0061	0.37	NO
49	AKT1	AKT1	AKT1	8502	0.0061	0.37	NO
50	RRAGB	RRAGB	RRAGB	8960	-0.0002	0.34	NO
51	FBXW11	FBXW11	FBXW11	9148	-0.0028	0.33	NO
52	KRAS	KRAS	KRAS	9364	-0.0063	0.32	NO
53	AKT1S1	AKT1S1	AKT1S1	9827	-0.013	0.3	NO
54	PRR5	PRR5	PRR5	10016	-0.015	0.29	NO
55	EEF2	EEF2	EEF2	10370	-0.021	0.28	NO
56	YWHAB	YWHAB	YWHAB	10495	-0.023	0.28	NO
57	MLST8	MLST8	MLST8	10744	-0.027	0.27	NO
58	CYCS	CYCS	CYCS	11050	-0.033	0.26	NO
59	EIF4B	EIF4B	EIF4B	11247	-0.036	0.25	NO
60	PDPK1	PDPK1	PDPK1	11777	-0.046	0.23	NO
61	RHOA	RHOA	RHOA	12463	-0.06	0.2	NO
62	YWHAH	YWHAH	YWHAH	12704	-0.066	0.2	NO
63	RPS6KA1	RPS6KA1	RPS6KA1	13008	-0.073	0.2	NO
64	SSPO	SSPO	SSPO	13687	-0.092	0.18	NO
65	MAPK3	MAPK3	MAPK3	14407	-0.12	0.16	NO
66	PPARGC1A	PPARGC1A	PPARGC1A	15612	-0.18	0.13	NO
67	PRKCA	PRKCA	PRKCA	16373	-0.23	0.13	NO

Figure S1. Get High-res Image This plot shows mRNAseq_cNMF expression data heatmap (on the left) a RunningEnrichmentScore(RES) plot (on the top right) and a Signal2Noise(S2N) plot (on the bottom right) of genes in the pathway: PID P73PATHWAY.

Figure S2. Get High-res Image For the top 5 core enriched genes in the pathway: PID P73PATHWAY, this volcano plot shows how much they are up/down-regulated and significant. The significance was calculated by empirical bayesian fit

×

genes ES table in pathway: PID MTOR 4PATHWAY

Table S2. Get Full Table This table shows a Running Enrichment Score (RES) of each gene in this pathway, that is, the enrichment score at this point in the ranked list of genes. All genes are ranked by Signal-to-Noise (S2N), a measure of similarity as default and are used to obtain ES matrix of all genes. In this way, GSEA tool uses expression pattern of not only overlapped genes but also not-overlapped genes to produce ES matrix.

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NINL	NINL	NINL	1200	0.26	0.0025	YES
2	TUBA4A	TUBA4A	TUBA4A	1878	0.18	0.013	YES
3	PLK4	PLK4	PLK4	2039	0.17	0.048	YES
4	TUBG2	TUBG2	TUBG2	2147	0.16	0.084	YES
5	TUBGCP5	TUBGCP5	TUBGCP5	2423	0.15	0.11	YES
6	CLASP1	CLASP1	CLASP1	2662	0.13	0.13	YES
7	NEDD1	NEDD1	NEDD1	3045	0.12	0.14	YES
8	CDK1	CDK1	CDK1	3060	0.12	0.16	YES
9	CCNB1	CCNB1	CCNB1	3491	0.1	0.17	YES
10	NEK2	NEK2	NEK2	3636	0.095	0.18	YES
11	CEP250	CEP250	CEP250	3782	0.091	0.2	YES
12	YWHAG	YWHAG	YWHAG	4068	0.082	0.2	YES
13	TUBG1	TUBG1	TUBG1	4174	0.08	0.22	YES
14	CEP164	CEP164	CEP164	4267	0.077	0.23	YES
15	CSNK1E	CSNK1E	CSNK1E	4282	0.076	0.25	YES
16	CEP70	CEP70	CEP70	4337	0.075	0.27	YES
17	DYNC1H1	DYNC1H1	DYNC1H1	4369	0.074	0.29	YES
18	CDK5RAP2	CDK5RAP2	CDK5RAP2	4376	0.074	0.3	YES
19	CKAP5	CKAP5	CKAP5	4411	0.073	0.32	YES
20	ALMS1	ALMS1	ALMS1	4429	0.073	0.34	YES
21	CETN2	CETN2	CETN2	4433	0.073	0.36	YES
22	DCTN1	DCTN1	DCTN1	4647	0.068	0.36	YES
23	CEP76	CEP76	CEP76	4689	0.068	0.38	YES
24	PCNT	PCNT	PCNT	4725	0.067	0.39	YES
25	AZI1	AZI1	AZI1	4807	0.065	0.4	YES
26	PLK1	PLK1	PLK1	4956	0.062	0.41	YES
27	TUBB	TUBB	TUBB	4981	0.061	0.43	YES
28	HAUS2	HAUS2	HAUS2	5022	0.06	0.44	YES
29	NUMA1	NUMA1	NUMA1	5057	0.06	0.45	YES
30	PAFAH1B1	PAFAH1B1	PAFAH1B1	5068	0.059	0.47	YES
31	YWHAE	YWHAE	YWHAE	5219	0.056	0.47	YES
32	CEP72	CEP72	CEP72	5224	0.056	0.49	YES
33	CEP63	CEP63	CEP63	5345	0.054	0.5	YES
34	TUBGCP6	TUBGCP6	TUBGCP6	5473	0.052	0.5	YES
35	DYNLL1	DYNLL1	DYNLL1	5698	0.048	0.5	YES
36	SDCCAG8	SDCCAG8	SDCCAG8	5966	0.043	0.5	NO
37	CEP135	CEP135	CEP135	6201	0.039	0.5	NO
38	CENPJ	CENPJ	CENPJ	6424	0.036	0.49	NO
39	HSP90AA1	HSP90AA1	HSP90AA1	6490	0.035	0.5	NO
40	CEP192	CEP192	CEP192	6757	0.031	0.49	NO
41	DCTN2	DCTN2	DCTN2	6936	0.028	0.49	NO
42	DYNC1I2	DYNC1I2	DYNC1I2	7206	0.024	0.48	NO
43	CEP290	CEP290	CEP290	7371	0.022	0.48	NO
44	DCTN3	DCTN3	DCTN3	7513	0.02	0.48	NO
45	AKAP9	AKAP9	AKAP9	7765	0.016	0.47	NO
46	SSNA1	SSNA1	SSNA1	7859	0.015	0.46	NO
47	ACTR1A	ACTR1A	ACTR1A	8080	0.012	0.46	NO
48	TUBGCP3	TUBGCP3	TUBGCP3	8110	0.012	0.46	NO
49	MAPRE1	MAPRE1	MAPRE1	8582	0.0052	0.43	NO
50	TUBGCP2	TUBGCP2	TUBGCP2	8687	0.0038	0.43	NO
51	PRKACA	PRKACA	PRKACA	9387	-0.0067	0.39	NO
52	PPP2R1A	PPP2R1A	PPP2R1A	9593	-0.0095	0.38	NO
53	CSNK1D	CSNK1D	CSNK1D	9676	-0.011	0.38	NO
54	OFD1	OFD1	OFD1	10597	-0.024	0.34	NO
55	TUBA1A	TUBA1A	TUBA1A	10787	-0.028	0.34	NO
56	PCM1	PCM1	PCM1	11192	-0.036	0.32	NO
57	CEP57	CEP57	CEP57	11556	-0.042	0.32	NO
58	FGFR1OP	FGFR1OP	FGFR1OP	13193	-0.078	0.25	NO
59	PRKAR2B	PRKAR2B	PRKAR2B	15801	-0.19	0.16	NO

Figure S3. Get High-res Image This plot shows mRNAseq_cNMF expression data heatmap (on the left) a RunningEnrichmentScore(RES) plot (on the top right) and a Signal2Noise(S2N) plot (on the bottom right) of genes in the pathway: PID MTOR 4PATHWAY.

Figure S4. Get High-res Image For the top 5 core enriched genes in the pathway: PID MTOR 4PATHWAY, this volcano plot shows how much they are up/down-regulated and significant. The significance was calculated by empirical bayesian fit

×

genes ES table in pathway: PID MYC PATHWAY

Table S3. Get Full Table This table shows a Running Enrichment Score (RES) of each gene in this pathway, that is, the enrichment score at this point in the ranked list of genes. All genes are ranked by Signal-to-Noise (S2N), a measure of similarity as default and are used to obtain ES matrix of all genes. In this way, GSEA tool uses expression pattern of not only overlapped genes but also not-overlapped genes to produce ES matrix.

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	GJB6	GJB6	GJB6	27	1	0.076	YES
2	GJB5	GJB5	GJB5	169	0.72	0.12	YES
3	TPD52L1	TPD52L1	TPD52L1	318	0.56	0.16	YES
4	GJB2	GJB2	GJB2	368	0.53	0.19	YES
5	GJA3	GJA3	GJA3	393	0.51	0.23	YES
6	GJB3	GJB3	GJB3	502	0.46	0.26	YES
7	CLTCL1	CLTCL1	CLTCL1	531	0.44	0.29	YES
8	GJB7	GJB7	GJB7	675	0.39	0.31	YES
9	GJA1	GJA1	GJA1	709	0.38	0.34	YES
10	GJB4	GJB4	GJB4	719	0.37	0.36	YES
11	DNM1	DNM1	DNM1	1802	0.19	0.32	NO
12	AP4E1	AP4E1	AP4E1	2346	0.15	0.3	NO
13	TFRC	TFRC	TFRC	3383	0.1	0.25	NO
14	AP2M1	AP2M1	AP2M1	3652	0.094	0.25	NO
15	HGS	HGS	HGS	3769	0.092	0.25	NO
16	GJA9	GJA9	GJA9	4122	0.081	0.24	NO
17	VPS4B	VPS4B	VPS4B	4745	0.066	0.21	NO
18	TJP1	TJP1	TJP1	5056	0.06	0.19	NO
19	VPS37D	VPS37D	VPS37D	5170	0.057	0.19	NO
20	AP1M1	AP1M1	AP1M1	5470	0.052	0.18	NO
21	IGF2R	IGF2R	IGF2R	5519	0.051	0.18	NO
22	STAM	STAM	STAM	5773	0.046	0.17	NO
23	SEC24B	SEC24B	SEC24B	5978	0.043	0.16	NO
24	AP1G1	AP1G1	AP1G1	6222	0.039	0.15	NO
25	VTA1	VTA1	VTA1	6252	0.038	0.15	NO
26	AP1B1	AP1B1	AP1B1	6320	0.037	0.15	NO
27	COPB2	COPB2	COPB2	6480	0.035	0.15	NO
28	SEC24C	SEC24C	SEC24C	6608	0.033	0.14	NO
29	CLTC	CLTC	CLTC	6774	0.03	0.14	NO
30	GBF1	GBF1	GBF1	6850	0.029	0.13	NO
31	AP3S1	AP3S1	AP3S1	6884	0.029	0.14	NO
32	CLTB	CLTB	CLTB	7054	0.026	0.13	NO
33	PLDN	PLDN	PLDN	7080	0.026	0.13	NO
34	SNAPIN	SNAPIN	SNAPIN	7627	0.018	0.1	NO
35	CHMP5	CHMP5	CHMP5	7654	0.018	0.1	NO
36	M6PR	M6PR	M6PR	7730	0.017	0.098	NO
37	PUM1	PUM1	PUM1	7818	0.016	0.094	NO
38	VPS37C	VPS37C	VPS37C	7916	0.015	0.09	NO
39	OCRL	OCRL	OCRL	8029	0.013	0.085	NO
40	AP3B1	AP3B1	AP3B1	8114	0.012	0.081	NO
41	PICALM	PICALM	PICALM	8172	0.011	0.079	NO
42	VPS4A	VPS4A	VPS4A	8238	0.01	0.076	NO
43	VAMP8	VAMP8	VAMP8	8276	0.0095	0.075	NO
44	GJD2	GJD2	GJD2	8481	0.0063	0.064	NO
45	VPS25	VPS25	VPS25	8497	0.0061	0.064	NO
46	VAMP7	VAMP7	VAMP7	8527	0.0058	0.063	NO
47	SEC31A	SEC31A	SEC31A	8711	0.0036	0.053	NO
48	VPS37A	VPS37A	VPS37A	8867	0.0012	0.045	NO
49	DNAJC6	DNAJC6	DNAJC6	8956	-0.00017	0.04	NO
50	SH3GL2	SH3GL2	SH3GL2	9062	-0.0017	0.035	NO
51	FTH1	FTH1	FTH1	9288	-0.0051	0.023	NO
52	COPG	COPG	COPG	9295	-0.0052	0.023	NO
53	COPB1	COPB1	COPB1	9337	-0.0059	0.022	NO
54	SNF8	SNF8	SNF8	9585	-0.0094	0.0089	NO
55	SEC23A	SEC23A	SEC23A	9606	-0.0097	0.0086	NO
56	YIPF6	YIPF6	YIPF6	9690	-0.011	0.0049	NO
57	GJC1	GJC1	GJC1	9734	-0.011	0.0034	NO
58	TSG101	TSG101	TSG101	9778	-0.012	0.002	NO
59	BLOC1S3	BLOC1S3	BLOC1S3	10074	-0.016	-0.013	NO
60	RPS27A	RPS27A	RPS27A	10338	-0.02	-0.025	NO
61	CLTA	CLTA	CLTA	10356	-0.021	-0.025	NO
62	NAPA	NAPA	NAPA	10369	-0.021	-0.024	NO
63	COPE	COPE	COPE	10372	-0.021	-0.022	NO
64	GJD4	GJD4	GJD4	10745	-0.027	-0.04	NO
65	HSPA8	HSPA8	HSPA8	10783	-0.028	-0.04	NO
66	ARF1	ARF1	ARF1	10803	-0.028	-0.039	NO
67	CHMP6	CHMP6	CHMP6	10806	-0.028	-0.037	NO
68	UBA52	UBA52	UBA52	10872	-0.029	-0.038	NO
69	COPA	COPA	COPA	10989	-0.032	-0.042	NO
70	HIP1R	HIP1R	HIP1R	11136	-0.034	-0.048	NO
71	VPS36	VPS36	VPS36	11205	-0.036	-0.049	NO
72	VPS28	VPS28	VPS28	11258	-0.037	-0.049	NO
73	CHMP4A	CHMP4A	CHMP4A	11268	-0.037	-0.046	NO
74	CNO	CNO	CNO	11432	-0.04	-0.052	NO
75	ARFGAP1	ARFGAP1	ARFGAP1	11567	-0.042	-0.056	NO
76	DNASE2	DNASE2	DNASE2	11570	-0.042	-0.053	NO
77	PREB	PREB	PREB	11586	-0.042	-0.051	NO
78	VPS37B	VPS37B	VPS37B	11610	-0.043	-0.049	NO
79	COPZ1	COPZ1	COPZ1	11622	-0.043	-0.046	NO
80	STAM2	STAM2	STAM2	11662	-0.044	-0.045	NO
81	NECAP1	NECAP1	NECAP1	11706	-0.045	-0.044	NO
82	SNX5	SNX5	SNX5	11753	-0.046	-0.043	NO
83	VAMP2	VAMP2	VAMP2	11994	-0.05	-0.052	NO
84	ARCN1	ARCN1	ARCN1	12051	-0.052	-0.052	NO
85	GAK	GAK	GAK	12247	-0.056	-0.058	NO
86	SORT1	SORT1	SORT1	12257	-0.056	-0.054	NO
87	DNM2	DNM2	DNM2	12309	-0.057	-0.053	NO
88	AP1S2	AP1S2	AP1S2	12409	-0.059	-0.054	NO
89	SNX2	SNX2	SNX2	12527	-0.062	-0.055	NO
90	STX4	STX4	STX4	12628	-0.064	-0.056	NO
91	PIK3C2A	PIK3C2A	PIK3C2A	12638	-0.064	-0.052	NO
92	RAB5C	RAB5C	RAB5C	12730	-0.066	-0.051	NO
93	SH3D19	SH3D19	SH3D19	12862	-0.069	-0.053	NO
94	AP1M2	AP1M2	AP1M2	12957	-0.072	-0.053	NO
95	CPD	CPD	CPD	12992	-0.072	-0.05	NO
96	CHMP2A	CHMP2A	CHMP2A	13199	-0.078	-0.055	NO
97	SRC	SRC	SRC	13256	-0.079	-0.052	NO
98	GNS	GNS	GNS	13312	-0.081	-0.049	NO
99	TXNDC5	TXNDC5	TXNDC5	13369	-0.082	-0.046	NO
100	SAR1B	SAR1B	SAR1B	13375	-0.082	-0.04	NO
101	SNAP23	SNAP23	SNAP23	13388	-0.083	-0.034	NO
102	SEC13	SEC13	SEC13	13576	-0.088	-0.038	NO
103	SNX9	SNX9	SNX9	13695	-0.092	-0.037	NO
104	AP1S1	AP1S1	AP1S1	13722	-0.093	-0.032	NO
105	FTL	FTL	FTL	13768	-0.094	-0.027	NO
106	TGOLN2	TGOLN2	TGOLN2	13873	-0.098	-0.026	NO
107	CHMP7	CHMP7	CHMP7	13897	-0.099	-0.019	NO
108	CHMP4B	CHMP4B	CHMP4B	14006	-0.1	-0.018	NO
109	MYO6	MYO6	MYO6	14086	-0.1	-0.014	NO
110	AP4B1	AP4B1	AP4B1	14459	-0.12	-0.025	NO
111	CHMP2B	CHMP2B	CHMP2B	14657	-0.13	-0.026	NO
112	BLOC1S1	BLOC1S1	BLOC1S1	14672	-0.13	-0.017	NO
113	TPD52	TPD52	TPD52	14712	-0.13	-0.0096	NO
114	SEC24D	SEC24D	SEC24D	14853	-0.14	-0.0069	NO
115	TBC1D8B	TBC1D8B	TBC1D8B	15012	-0.14	-0.0046	NO
116	CTSZ	CTSZ	CTSZ	15195	-0.15	-0.003	NO
117	CHMP4C	CHMP4C	CHMP4C	15266	-0.16	0.0051	NO
118	DTNBP1	DTNBP1	DTNBP1	15426	-0.17	0.009	NO
119	DAB2	DAB2	DAB2	16081	-0.21	-0.01	NO
120	GJC2	GJC2	GJC2	16193	-0.22	-0.00018	NO
121	GJA5	GJA5	GJA5	16709	-0.26	-0.0087	NO
122	GJA4	GJA4	GJA4	17284	-0.31	-0.016	NO
123	ARRB1	ARRB1	ARRB1	18370	-0.51	-0.036	NO
124	GJB1	GJB1	GJB1	18670	-0.74	0.0029	NO

Figure S5. Get High-res Image This plot shows mRNAseq_cNMF expression data heatmap (on the left) a RunningEnrichmentScore(RES) plot (on the top right) and a Signal2Noise(S2N) plot (on the bottom right) of genes in the pathway: PID MYC PATHWAY.

Figure S6. Get High-res Image For the top 5 core enriched genes in the pathway: PID MYC PATHWAY, this volcano plot shows how much they are up/down-regulated and significant. The significance was calculated by empirical bayesian fit

×

genes ES table in pathway: PID DELTANP63PATHWAY

Table S4. Get Full Table This table shows a Running Enrichment Score (RES) of each gene in this pathway, that is, the enrichment score at this point in the ranked list of genes. All genes are ranked by Signal-to-Noise (S2N), a measure of similarity as default and are used to obtain ES matrix of all genes. In this way, GSEA tool uses expression pattern of not only overlapped genes but also not-overlapped genes to produce ES matrix.

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	KRT5	KRT5	KRT5	3	1.2	0.12	YES
2	KRT14	KRT14	KRT14	12	1.2	0.23	YES
3	TP63	TP63	TP63	14	1.1	0.34	YES
4	DLX5	DLX5	DLX5	120	0.81	0.41	YES
5	RAB38	RAB38	RAB38	141	0.76	0.48	YES
6	IL1A	IL1A	IL1A	227	0.64	0.54	YES
7	SFN	SFN	SFN	320	0.56	0.59	YES
8	PERP	PERP	PERP	617	0.41	0.61	YES
9	NRG1	NRG1	NRG1	802	0.35	0.63	YES
10	DLX6	DLX6	DLX6	910	0.32	0.66	YES
11	TCF7L1	TCF7L1	TCF7L1	1400	0.24	0.66	YES
12	ADA	ADA	ADA	1772	0.2	0.66	YES
13	SEC14L2	SEC14L2	SEC14L2	2325	0.15	0.64	YES
14	ITGA3	ITGA3	ITGA3	2806	0.13	0.63	YES
15	RRAD	RRAD	RRAD	2821	0.13	0.64	YES
16	CCNB2	CCNB2	CCNB2	2959	0.12	0.64	YES
17	FASN	FASN	FASN	3131	0.11	0.64	YES
18	BDKRB2	BDKRB2	BDKRB2	3177	0.11	0.65	YES
19	HELLS	HELLS	HELLS	3225	0.11	0.66	YES
20	TOP2A	TOP2A	TOP2A	3226	0.11	0.67	YES
21	NOTCH1	NOTCH1	NOTCH1	3378	0.1	0.67	YES
22	BRCA2	BRCA2	BRCA2	4050	0.083	0.64	NO
23	GSK3B	GSK3B	GSK3B	4133	0.08	0.65	NO
24	T	T	T	4301	0.076	0.65	NO
25	HBP1	HBP1	HBP1	4840	0.064	0.62	NO
26	YAP1	YAP1	YAP1	4955	0.062	0.62	NO
27	RUNX1	RUNX1	RUNX1	5117	0.058	0.62	NO
28	FOSL2	FOSL2	FOSL2	5643	0.049	0.6	NO
29	MRE11A	MRE11A	MRE11A	6354	0.037	0.56	NO
30	ITCH	ITCH	ITCH	6412	0.036	0.56	NO
31	FBXW7	FBXW7	FBXW7	6452	0.035	0.56	NO
32	HES1	HES1	HES1	6477	0.035	0.57	NO
33	CEBPD	CEBPD	CEBPD	7284	0.023	0.53	NO
34	STXBP4	STXBP4	STXBP4	7442	0.021	0.52	NO
35	ADRM1	ADRM1	ADRM1	7781	0.016	0.5	NO
36	MDM2	MDM2	MDM2	7999	0.014	0.49	NO
37	PPP2R5A	PPP2R5A	PPP2R5A	8308	0.0089	0.48	NO
38	COL5A1	COL5A1	COL5A1	9927	-0.014	0.39	NO
39	GNB2L1	GNB2L1	GNB2L1	11108	-0.034	0.33	NO
40	IGFBP3	IGFBP3	IGFBP3	11298	-0.037	0.32	NO
41	VDR	VDR	VDR	11500	-0.041	0.32	NO
42	ATM	ATM	ATM	11697	-0.045	0.31	NO
43	WWP1	WWP1	WWP1	12231	-0.056	0.29	NO
44	AXL	AXL	AXL	13205	-0.078	0.24	NO
45	CDKN2A	CDKN2A	CDKN2A	13490	-0.086	0.24	NO
46	POU2F2	POU2F2	POU2F2	16203	-0.22	0.11	NO
47	GPX2	GPX2	GPX2	16251	-0.22	0.13	NO

Figure S7. Get High-res Image This plot shows mRNAseq_cNMF expression data heatmap (on the left) a RunningEnrichmentScore(RES) plot (on the top right) and a Signal2Noise(S2N) plot (on the bottom right) of genes in the pathway: PID DELTANP63PATHWAY.

Figure S8. Get High-res Image For the top 5 core enriched genes in the pathway: PID DELTANP63PATHWAY, this volcano plot shows how much they are up/down-regulated and significant. The significance was calculated by empirical bayesian fit

×

genes ES table in pathway: PID AURORA A PATHWAY

Table S5. Get Full Table This table shows a Running Enrichment Score (RES) of each gene in this pathway, that is, the enrichment score at this point in the ranked list of genes. All genes are ranked by Signal-to-Noise (S2N), a measure of similarity as default and are used to obtain ES matrix of all genes. In this way, GSEA tool uses expression pattern of not only overlapped genes but also not-overlapped genes to produce ES matrix.

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CCNA1	CCNA1	CCNA1	187	0.7	0.11	YES
2	NINL	NINL	NINL	1200	0.26	0.1	YES
3	TUBA4A	TUBA4A	TUBA4A	1878	0.18	0.1	YES
4	PLK4	PLK4	PLK4	2039	0.17	0.12	YES
5	PKMYT1	PKMYT1	PKMYT1	2133	0.17	0.14	YES
6	TUBG2	TUBG2	TUBG2	2147	0.16	0.17	YES
7	MNAT1	MNAT1	MNAT1	2390	0.15	0.19	YES
8	TUBGCP5	TUBGCP5	TUBGCP5	2423	0.15	0.21	YES
9	CLASP1	CLASP1	CLASP1	2662	0.13	0.22	YES
10	CCNB2	CCNB2	CCNB2	2959	0.12	0.23	YES
11	NEDD1	NEDD1	NEDD1	3045	0.12	0.24	YES
12	CDK1	CDK1	CDK1	3060	0.12	0.26	YES
13	WEE1	WEE1	WEE1	3127	0.11	0.28	YES
14	CCNB1	CCNB1	CCNB1	3491	0.1	0.28	YES
15	CCNA2	CCNA2	CCNA2	3617	0.096	0.29	YES
16	NEK2	NEK2	NEK2	3636	0.095	0.3	YES
17	CEP250	CEP250	CEP250	3782	0.091	0.31	YES
18	YWHAG	YWHAG	YWHAG	4068	0.082	0.31	YES
19	TUBG1	TUBG1	TUBG1	4174	0.08	0.32	YES
20	CEP164	CEP164	CEP164	4267	0.077	0.32	YES
21	CSNK1E	CSNK1E	CSNK1E	4282	0.076	0.34	YES
22	CEP70	CEP70	CEP70	4337	0.075	0.35	YES
23	DYNC1H1	DYNC1H1	DYNC1H1	4369	0.074	0.36	YES
24	CDK5RAP2	CDK5RAP2	CDK5RAP2	4376	0.074	0.37	YES
25	XPO1	XPO1	XPO1	4378	0.074	0.38	YES
26	CKAP5	CKAP5	CKAP5	4411	0.073	0.4	YES
27	ALMS1	ALMS1	ALMS1	4429	0.073	0.41	YES
28	CETN2	CETN2	CETN2	4433	0.073	0.42	YES
29	DCTN1	DCTN1	DCTN1	4647	0.068	0.42	YES
30	CEP76	CEP76	CEP76	4689	0.068	0.43	YES
31	PCNT	PCNT	PCNT	4725	0.067	0.44	YES
32	AZI1	AZI1	AZI1	4807	0.065	0.45	YES
33	PLK1	PLK1	PLK1	4956	0.062	0.45	YES
34	TUBB	TUBB	TUBB	4981	0.061	0.46	YES
35	CDC25A	CDC25A	CDC25A	5006	0.061	0.47	YES
36	HAUS2	HAUS2	HAUS2	5022	0.06	0.48	YES
37	NUMA1	NUMA1	NUMA1	5057	0.06	0.49	YES
38	PAFAH1B1	PAFAH1B1	PAFAH1B1	5068	0.059	0.5	YES
39	YWHAE	YWHAE	YWHAE	5219	0.056	0.5	YES
40	CEP72	CEP72	CEP72	5224	0.056	0.51	YES
41	CEP63	CEP63	CEP63	5345	0.054	0.51	YES
42	TUBGCP6	TUBGCP6	TUBGCP6	5473	0.052	0.51	YES
43	E2F3	E2F3	E2F3	5520	0.051	0.52	YES
44	DYNLL1	DYNLL1	DYNLL1	5698	0.048	0.52	YES
45	E2F1	E2F1	E2F1	5954	0.043	0.51	YES
46	SDCCAG8	SDCCAG8	SDCCAG8	5966	0.043	0.52	YES
47	CDK7	CDK7	CDK7	6142	0.04	0.52	YES
48	CEP135	CEP135	CEP135	6201	0.039	0.52	YES
49	CENPJ	CENPJ	CENPJ	6424	0.036	0.52	YES
50	HSP90AA1	HSP90AA1	HSP90AA1	6490	0.035	0.52	YES
51	CDC25C	CDC25C	CDC25C	6534	0.034	0.52	YES
52	CEP192	CEP192	CEP192	6757	0.031	0.52	NO
53	DCTN2	DCTN2	DCTN2	6936	0.028	0.51	NO
54	CDC25B	CDC25B	CDC25B	6968	0.028	0.51	NO
55	CDK2	CDK2	CDK2	6985	0.027	0.52	NO
56	DYNC1I2	DYNC1I2	DYNC1I2	7206	0.024	0.51	NO
57	CEP290	CEP290	CEP290	7371	0.022	0.51	NO
58	DCTN3	DCTN3	DCTN3	7513	0.02	0.5	NO
59	AKAP9	AKAP9	AKAP9	7765	0.016	0.49	NO
60	SSNA1	SSNA1	SSNA1	7859	0.015	0.49	NO
61	ACTR1A	ACTR1A	ACTR1A	8080	0.012	0.48	NO
62	TUBGCP3	TUBGCP3	TUBGCP3	8110	0.012	0.48	NO
63	MAPRE1	MAPRE1	MAPRE1	8582	0.0052	0.46	NO
64	TUBGCP2	TUBGCP2	TUBGCP2	8687	0.0038	0.45	NO
65	PRKACA	PRKACA	PRKACA	9387	-0.0067	0.41	NO
66	PPP2R1A	PPP2R1A	PPP2R1A	9593	-0.0095	0.4	NO
67	CSNK1D	CSNK1D	CSNK1D	9676	-0.011	0.4	NO
68	OFD1	OFD1	OFD1	10597	-0.024	0.36	NO
69	TUBA1A	TUBA1A	TUBA1A	10787	-0.028	0.35	NO
70	PCM1	PCM1	PCM1	11192	-0.036	0.34	NO
71	CEP57	CEP57	CEP57	11556	-0.042	0.32	NO
72	CCNH	CCNH	CCNH	12962	-0.072	0.26	NO
73	FGFR1OP	FGFR1OP	FGFR1OP	13193	-0.078	0.26	NO
74	PRKAR2B	PRKAR2B	PRKAR2B	15801	-0.19	0.16	NO

Figure S9. Get High-res Image This plot shows mRNAseq_cNMF expression data heatmap (on the left) a RunningEnrichmentScore(RES) plot (on the top right) and a Signal2Noise(S2N) plot (on the bottom right) of genes in the pathway: PID AURORA A PATHWAY.

Figure S10. Get High-res Image For the top 5 core enriched genes in the pathway: PID AURORA A PATHWAY, this volcano plot shows how much they are up/down-regulated and significant. The significance was calculated by empirical bayesian fit

×

genes ES table in pathway: PID TAP63PATHWAY

Table S6. Get Full Table This table shows a Running Enrichment Score (RES) of each gene in this pathway, that is, the enrichment score at this point in the ranked list of genes. All genes are ranked by Signal-to-Noise (S2N), a measure of similarity as default and are used to obtain ES matrix of all genes. In this way, GSEA tool uses expression pattern of not only overlapped genes but also not-overlapped genes to produce ES matrix.

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NINL	NINL	NINL	1200	0.26	0.013	YES
2	TUBA4A	TUBA4A	TUBA4A	1878	0.18	0.031	YES
3	PLK4	PLK4	PLK4	2039	0.17	0.073	YES
4	CLASP1	CLASP1	CLASP1	2662	0.13	0.079	YES
5	NEDD1	NEDD1	NEDD1	3045	0.12	0.093	YES
6	CDK1	CDK1	CDK1	3060	0.12	0.13	YES
7	NEK2	NEK2	NEK2	3636	0.095	0.12	YES
8	CEP250	CEP250	CEP250	3782	0.091	0.14	YES
9	YWHAG	YWHAG	YWHAG	4068	0.082	0.15	YES
10	TUBG1	TUBG1	TUBG1	4174	0.08	0.17	YES
11	CEP164	CEP164	CEP164	4267	0.077	0.19	YES
12	CSNK1E	CSNK1E	CSNK1E	4282	0.076	0.21	YES
13	CEP70	CEP70	CEP70	4337	0.075	0.23	YES
14	DYNC1H1	DYNC1H1	DYNC1H1	4369	0.074	0.25	YES
15	CDK5RAP2	CDK5RAP2	CDK5RAP2	4376	0.074	0.27	YES
16	CKAP5	CKAP5	CKAP5	4411	0.073	0.29	YES
17	ALMS1	ALMS1	ALMS1	4429	0.073	0.31	YES
18	CETN2	CETN2	CETN2	4433	0.073	0.33	YES
19	DCTN1	DCTN1	DCTN1	4647	0.068	0.34	YES
20	CEP76	CEP76	CEP76	4689	0.068	0.36	YES
21	PCNT	PCNT	PCNT	4725	0.067	0.37	YES
22	AZI1	AZI1	AZI1	4807	0.065	0.39	YES
23	PLK1	PLK1	PLK1	4956	0.062	0.4	YES
24	TUBB	TUBB	TUBB	4981	0.061	0.42	YES
25	HAUS2	HAUS2	HAUS2	5022	0.06	0.43	YES
26	PAFAH1B1	PAFAH1B1	PAFAH1B1	5068	0.059	0.45	YES
27	YWHAE	YWHAE	YWHAE	5219	0.056	0.46	YES
28	CEP72	CEP72	CEP72	5224	0.056	0.47	YES
29	CEP63	CEP63	CEP63	5345	0.054	0.48	YES
30	DYNLL1	DYNLL1	DYNLL1	5698	0.048	0.48	NO
31	SDCCAG8	SDCCAG8	SDCCAG8	5966	0.043	0.47	NO
32	CEP135	CEP135	CEP135	6201	0.039	0.47	NO
33	CENPJ	CENPJ	CENPJ	6424	0.036	0.47	NO
34	HSP90AA1	HSP90AA1	HSP90AA1	6490	0.035	0.48	NO
35	CEP192	CEP192	CEP192	6757	0.031	0.47	NO
36	DCTN2	DCTN2	DCTN2	6936	0.028	0.47	NO
37	DYNC1I2	DYNC1I2	DYNC1I2	7206	0.024	0.46	NO
38	CEP290	CEP290	CEP290	7371	0.022	0.46	NO
39	DCTN3	DCTN3	DCTN3	7513	0.02	0.46	NO
40	AKAP9	AKAP9	AKAP9	7765	0.016	0.45	NO
41	SSNA1	SSNA1	SSNA1	7859	0.015	0.45	NO
42	ACTR1A	ACTR1A	ACTR1A	8080	0.012	0.44	NO
43	MAPRE1	MAPRE1	MAPRE1	8582	0.0052	0.42	NO
44	PRKACA	PRKACA	PRKACA	9387	-0.0067	0.38	NO
45	PPP2R1A	PPP2R1A	PPP2R1A	9593	-0.0095	0.37	NO
46	CSNK1D	CSNK1D	CSNK1D	9676	-0.011	0.37	NO
47	OFD1	OFD1	OFD1	10597	-0.024	0.32	NO
48	TUBA1A	TUBA1A	TUBA1A	10787	-0.028	0.32	NO
49	PCM1	PCM1	PCM1	11192	-0.036	0.31	NO
50	CEP57	CEP57	CEP57	11556	-0.042	0.3	NO
51	FGFR1OP	FGFR1OP	FGFR1OP	13193	-0.078	0.24	NO
52	PRKAR2B	PRKAR2B	PRKAR2B	15801	-0.19	0.16	NO

Figure S11. Get High-res Image This plot shows mRNAseq_cNMF expression data heatmap (on the left) a RunningEnrichmentScore(RES) plot (on the top right) and a Signal2Noise(S2N) plot (on the bottom right) of genes in the pathway: PID TAP63PATHWAY.

Figure S12. Get High-res Image For the top 5 core enriched genes in the pathway: PID TAP63PATHWAY, this volcano plot shows how much they are up/down-regulated and significant. The significance was calculated by empirical bayesian fit

×

genes ES table in pathway: PID P53REGULATIONPATHWAY

Table S7. Get Full Table This table shows a Running Enrichment Score (RES) of each gene in this pathway, that is, the enrichment score at this point in the ranked list of genes. All genes are ranked by Signal-to-Noise (S2N), a measure of similarity as default and are used to obtain ES matrix of all genes. In this way, GSEA tool uses expression pattern of not only overlapped genes but also not-overlapped genes to produce ES matrix.

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SPHK1	SPHK1	SPHK1	717	0.37	0.24	YES
2	KIFC3	KIFC3	KIFC3	2268	0.16	0.28	YES
3	CCT4	CCT4	CCT4	4290	0.076	0.23	YES
4	CCT5	CCT5	CCT5	4358	0.074	0.28	YES
5	USP11	USP11	USP11	5360	0.054	0.27	YES
6	KIF13A	KIF13A	KIF13A	5679	0.048	0.29	YES
7	CCT6A	CCT6A	CCT6A	5952	0.043	0.31	YES
8	TCP1	TCP1	TCP1	5990	0.042	0.34	YES
9	FBXW2	FBXW2	FBXW2	6051	0.041	0.37	YES
10	FKBP9	FKBP9	FKBP9	6435	0.035	0.37	YES
11	FBXW7	FBXW7	FBXW7	6452	0.035	0.4	YES
12	FBXW4	FBXW4	FBXW4	6454	0.035	0.43	YES
13	CCT7	CCT7	CCT7	6476	0.035	0.45	YES
14	CCT8	CCT8	CCT8	6778	0.03	0.46	YES
15	CCT2	CCT2	CCT2	7223	0.024	0.45	YES
16	CCT3	CCT3	CCT3	7294	0.023	0.47	YES
17	XRN2	XRN2	XRN2	7857	0.015	0.45	NO
18	NOP56	NOP56	NOP56	7878	0.015	0.46	NO
19	FBXL3	FBXL3	FBXL3	8160	0.011	0.45	NO
20	LONP2	LONP2	LONP2	9325	-0.0056	0.39	NO
21	FBXL5	FBXL5	FBXL5	9666	-0.011	0.38	NO
22	FBXO6	FBXO6	FBXO6	9857	-0.013	0.38	NO
23	ARFGEF2	ARFGEF2	ARFGEF2	9952	-0.015	0.39	NO
24	AP3M1	AP3M1	AP3M1	10209	-0.018	0.39	NO
25	FBXW5	FBXW5	FBXW5	10912	-0.03	0.38	NO
26	FBXO4	FBXO4	FBXO4	12209	-0.055	0.35	NO

Figure S13. Get High-res Image This plot shows mRNAseq_cNMF expression data heatmap (on the left) a RunningEnrichmentScore(RES) plot (on the top right) and a Signal2Noise(S2N) plot (on the bottom right) of genes in the pathway: PID P53REGULATIONPATHWAY.

Figure S14. Get High-res Image For the top 5 core enriched genes in the pathway: PID P53REGULATIONPATHWAY, this volcano plot shows how much they are up/down-regulated and significant. The significance was calculated by empirical bayesian fit

×

genes ES table in pathway: REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS

Table S8. Get Full Table This table shows a Running Enrichment Score (RES) of each gene in this pathway, that is, the enrichment score at this point in the ranked list of genes. All genes are ranked by Signal-to-Noise (S2N), a measure of similarity as default and are used to obtain ES matrix of all genes. In this way, GSEA tool uses expression pattern of not only overlapped genes but also not-overlapped genes to produce ES matrix.

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NUP155	NUP155	NUP155	2534	0.14	-0.064	YES
2	NUP210	NUP210	NUP210	2769	0.13	-0.011	YES
3	NUP153	NUP153	NUP153	3176	0.11	0.024	YES
4	NUP205	NUP205	NUP205	3371	0.1	0.067	YES
5	NUP188	NUP188	NUP188	3377	0.1	0.12	YES
6	NUP93	NUP93	NUP93	4067	0.082	0.12	YES
7	NUP37	NUP37	NUP37	4377	0.074	0.15	YES
8	CPSF3	CPSF3	CPSF3	4393	0.074	0.18	YES
9	NUP107	NUP107	NUP107	4416	0.073	0.22	YES
10	NCBP2	NCBP2	NCBP2	4697	0.068	0.24	YES
11	NUP54	NUP54	NUP54	4760	0.066	0.27	YES
12	CPSF2	CPSF2	CPSF2	4938	0.062	0.29	YES
13	NUP50	NUP50	NUP50	5144	0.058	0.31	YES
14	NUP85	NUP85	NUP85	5227	0.056	0.33	YES
15	RBM8A	RBM8A	RBM8A	5338	0.054	0.36	YES
16	SEH1L	SEH1L	SEH1L	5410	0.053	0.38	YES
17	NUP133	NUP133	NUP133	5422	0.053	0.4	YES
18	EIF4E	EIF4E	EIF4E	5968	0.043	0.4	YES
19	RAE1	RAE1	RAE1	5975	0.043	0.42	YES
20	NXF1	NXF1	NXF1	6070	0.041	0.44	YES
21	NUP214	NUP214	NUP214	6151	0.04	0.45	YES
22	TPR	TPR	TPR	6362	0.036	0.46	YES
23	SRRM1	SRRM1	SRRM1	6513	0.034	0.47	YES
24	DHX38	DHX38	DHX38	6622	0.032	0.48	YES
25	SLBP	SLBP	SLBP	6688	0.032	0.49	YES
26	UPF3B	UPF3B	UPF3B	6690	0.032	0.51	YES
27	NUPL1	NUPL1	NUPL1	6798	0.03	0.52	YES
28	POM121	POM121	POM121	6829	0.03	0.53	YES
29	U2AF1	U2AF1	U2AF1	7226	0.024	0.52	YES
30	RANBP2	RANBP2	RANBP2	7280	0.023	0.53	YES
31	RNPS1	RNPS1	RNPS1	7288	0.023	0.54	YES
32	THOC4	THOC4	THOC4	7312	0.022	0.55	YES
33	NUP35	NUP35	NUP35	7690	0.017	0.54	NO
34	NUP88	NUP88	NUP88	7789	0.016	0.54	NO
35	NUPL2	NUPL2	NUPL2	7986	0.014	0.54	NO
36	NCBP1	NCBP1	NCBP1	8417	0.0073	0.52	NO
37	NFX1	NFX1	NFX1	8607	0.005	0.51	NO
38	AAAS	AAAS	AAAS	8940	0.00012	0.5	NO
39	CPSF1	CPSF1	CPSF1	8964	-0.00024	0.49	NO
40	NUP62	NUP62	NUP62	9120	-0.0024	0.49	NO
41	NUP43	NUP43	NUP43	9343	-0.006	0.48	NO
42	U2AF2	U2AF2	U2AF2	9532	-0.0086	0.47	NO
43	CDC40	CDC40	CDC40	9685	-0.011	0.47	NO
44	MAGOH	MAGOH	MAGOH	10749	-0.027	0.43	NO

Figure S15. Get High-res Image This plot shows mRNAseq_cNMF expression data heatmap (on the left) a RunningEnrichmentScore(RES) plot (on the top right) and a Signal2Noise(S2N) plot (on the bottom right) of genes in the pathway: REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS.

Figure S16. Get High-res Image For the top 5 core enriched genes in the pathway: REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS, this volcano plot shows how much they are up/down-regulated and significant. The significance was calculated by empirical bayesian fit

×

genes ES table in pathway: REACTOME MEMBRANE TRAFFICKING

Table S9. Get Full Table This table shows a Running Enrichment Score (RES) of each gene in this pathway, that is, the enrichment score at this point in the ranked list of genes. All genes are ranked by Signal-to-Noise (S2N), a measure of similarity as default and are used to obtain ES matrix of all genes. In this way, GSEA tool uses expression pattern of not only overlapped genes but also not-overlapped genes to produce ES matrix.

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PKP1	PKP1	PKP1	6	1.2	0.19	YES
2	DSG3	DSG3	DSG3	76	0.91	0.34	YES
3	DSG1	DSG1	DSG1	103	0.84	0.47	YES
4	DSP	DSP	DSP	775	0.36	0.49	YES
5	PLEC	PLEC	PLEC	3431	0.1	0.37	NO
6	FNTA	FNTA	FNTA	3614	0.096	0.37	NO
7	LMNA	LMNA	LMNA	4638	0.069	0.33	NO
8	TJP1	TJP1	TJP1	5056	0.06	0.32	NO
9	CDH1	CDH1	CDH1	5277	0.056	0.31	NO
10	PTK2	PTK2	PTK2	6153	0.04	0.27	NO
11	DBNL	DBNL	DBNL	6174	0.04	0.28	NO
12	MST4	MST4	MST4	6182	0.04	0.28	NO
13	STK24	STK24	STK24	6407	0.036	0.28	NO
14	BCAP31	BCAP31	BCAP31	7278	0.023	0.24	NO
15	ACIN1	ACIN1	ACIN1	7286	0.023	0.24	NO
16	APC	APC	APC	7462	0.021	0.23	NO
17	MAPT	MAPT	MAPT	7482	0.02	0.24	NO
18	BIRC2	BIRC2	BIRC2	7538	0.02	0.24	NO
19	CTNNB1	CTNNB1	CTNNB1	8380	0.0079	0.19	NO
20	GSN	GSN	GSN	8597	0.0051	0.18	NO
21	ROCK1	ROCK1	ROCK1	9198	-0.0037	0.15	NO
22	DSG2	DSG2	DSG2	9412	-0.007	0.14	NO
23	LMNB1	LMNB1	LMNB1	9649	-0.01	0.13	NO
24	CASP3	CASP3	CASP3	11319	-0.038	0.045	NO
25	ADD1	ADD1	ADD1	11431	-0.04	0.045	NO
26	SPTAN1	SPTAN1	SPTAN1	11826	-0.047	0.032	NO
27	PRKCD	PRKCD	PRKCD	13187	-0.077	-0.029	NO
28	VIM	VIM	VIM	13310	-0.081	-0.022	NO
29	TJP2	TJP2	TJP2	13363	-0.082	-0.012	NO
30	CASP8	CASP8	CASP8	13463	-0.085	-0.0031	NO
31	CASP7	CASP7	CASP7	13694	-0.092	-0.00059	NO
32	LOC647859	LOC647859	LOC647859	14394	-0.12	-0.019	NO
33	PRKCQ	PRKCQ	PRKCQ	14552	-0.12	-0.0074	NO
34	SATB1	SATB1	SATB1	14838	-0.14	-0.00061	NO
35	CASP6	CASP6	CASP6	16379	-0.23	-0.046	NO
36	BMX	BMX	BMX	16919	-0.28	-0.03	NO
37	OCLN	OCLN	OCLN	17601	-0.35	-0.0097	NO
38	GAS2	GAS2	GAS2	18082	-0.43	0.034	NO

Figure S17. Get High-res Image This plot shows mRNAseq_cNMF expression data heatmap (on the left) a RunningEnrichmentScore(RES) plot (on the top right) and a Signal2Noise(S2N) plot (on the bottom right) of genes in the pathway: REACTOME MEMBRANE TRAFFICKING.

Figure S18. Get High-res Image For the top 5 core enriched genes in the pathway: REACTOME MEMBRANE TRAFFICKING, this volcano plot shows how much they are up/down-regulated and significant. The significance was calculated by empirical bayesian fit

×

genes ES table in pathway: REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES

Table S10. Get Full Table This table shows a Running Enrichment Score (RES) of each gene in this pathway, that is, the enrichment score at this point in the ranked list of genes. All genes are ranked by Signal-to-Noise (S2N), a measure of similarity as default and are used to obtain ES matrix of all genes. In this way, GSEA tool uses expression pattern of not only overlapped genes but also not-overlapped genes to produce ES matrix.

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	JUB	JUB	JUB	1045	0.29	0.069	YES
2	CENPA	CENPA	CENPA	1584	0.22	0.13	YES
3	BIRC5	BIRC5	BIRC5	1733	0.2	0.21	YES
4	DLGAP5	DLGAP5	DLGAP5	2163	0.16	0.26	YES
5	AURKB	AURKB	AURKB	2446	0.14	0.3	YES
6	NDEL1	NDEL1	NDEL1	2669	0.13	0.35	YES
7	BRCA1	BRCA1	BRCA1	3007	0.12	0.38	YES
8	TPX2	TPX2	TPX2	3534	0.098	0.39	YES
9	FZR1	FZR1	FZR1	3589	0.097	0.43	YES
10	GSK3B	GSK3B	GSK3B	4133	0.08	0.44	YES
11	GIT1	GIT1	GIT1	4319	0.075	0.46	YES
12	CKAP5	CKAP5	CKAP5	4411	0.073	0.49	YES
13	TACC3	TACC3	TACC3	4941	0.062	0.48	YES
14	RAN	RAN	RAN	5005	0.061	0.51	YES
15	RASA1	RASA1	RASA1	5015	0.06	0.53	YES
16	NFKBIA	NFKBIA	NFKBIA	5617	0.049	0.52	NO
17	GADD45A	GADD45A	GADD45A	6423	0.036	0.49	NO
18	CDC25B	CDC25B	CDC25B	6968	0.028	0.48	NO
19	MDM2	MDM2	MDM2	7999	0.014	0.43	NO
20	PPP2R5D	PPP2R5D	PPP2R5D	8476	0.0064	0.4	NO
21	AKT1	AKT1	AKT1	8502	0.0061	0.4	NO
22	AURKA	AURKA	AURKA	8652	0.0044	0.4	NO
23	PRKACA	PRKACA	PRKACA	9387	-0.0067	0.36	NO
24	OAZ1	OAZ1	OAZ1	9577	-0.0093	0.36	NO
25	AURKAIP1	AURKAIP1	AURKAIP1	9887	-0.014	0.35	NO
26	PAK1	PAK1	PAK1	10068	-0.016	0.34	NO
27	ARHGEF7	ARHGEF7	ARHGEF7	10643	-0.025	0.32	NO
28	TDRD7	TDRD7	TDRD7	10766	-0.028	0.33	NO
29	TP53	TP53	TP53	11418	-0.039	0.31	NO
30	TACC1	TACC1	TACC1	13048	-0.074	0.25	NO
31	CPEB1	CPEB1	CPEB1	14354	-0.12	0.23	NO

Figure S19. Get High-res Image This plot shows mRNAseq_cNMF expression data heatmap (on the left) a RunningEnrichmentScore(RES) plot (on the top right) and a Signal2Noise(S2N) plot (on the bottom right) of genes in the pathway: REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES.

Figure S20. Get High-res Image For the top 5 core enriched genes in the pathway: REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES, this volcano plot shows how much they are up/down-regulated and significant. The significance was calculated by empirical bayesian fit

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ALDOB	ALDOB	ALDOB	77	0.56	0.24	YES
2	FBP1	FBP1	FBP1	336	0.39	0.39	YES
3	FBP2	FBP2	FBP2	709	0.27	0.49	YES
4	RBKS	RBKS	RBKS	906	0.24	0.58	YES
5	RPIA	RPIA	RPIA	1463	0.17	0.63	YES
6	LOC729020	LOC729020	LOC729020	3075	0.081	0.57	NO
7	TKTL1	TKTL1	TKTL1	5013	0.041	0.49	NO
8	TKTL2	TKTL2	TKTL2	5231	0.038	0.49	NO
9	PFKL	PFKL	PFKL	5320	0.036	0.5	NO
10	RPE	RPE	RPE	5339	0.036	0.52	NO
11	PRPS2	PRPS2	PRPS2	5866	0.029	0.5	NO
12	GPI	GPI	GPI	7102	0.013	0.44	NO
13	TALDO1	TALDO1	TALDO1	7181	0.012	0.44	NO
14	ALDOA	ALDOA	ALDOA	7450	0.0096	0.44	NO
15	PFKP	PFKP	PFKP	7494	0.0091	0.44	NO
16	TKT	TKT	TKT	7948	0.0038	0.41	NO
17	DERA	DERA	DERA	8275	0.00028	0.4	NO
18	PGM1	PGM1	PGM1	8806	-0.0062	0.37	NO
19	PGLS	PGLS	PGLS	9140	-0.01	0.36	NO
20	PRPS1L1	PRPS1L1	PRPS1L1	9756	-0.018	0.33	NO
21	PGD	PGD	PGD	10600	-0.03	0.3	NO
22	PGM2	PGM2	PGM2	10812	-0.034	0.3	NO
23	PRPS1	PRPS1	PRPS1	10948	-0.036	0.31	NO
24	PFKM	PFKM	PFKM	11938	-0.052	0.28	NO
25	H6PD	H6PD	H6PD	12006	-0.053	0.3	NO
26	ALDOC	ALDOC	ALDOC	12126	-0.055	0.32	NO
27	G6PD	G6PD	G6PD	13266	-0.082	0.29	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ACSM3	ACSM3	ACSM3	113	0.52	0.15	YES
2	HMGCS2	HMGCS2	HMGCS2	121	0.51	0.3	YES
3	ACSM1	ACSM1	ACSM1	996	0.23	0.32	YES
4	ACADS	ACADS	ACADS	1211	0.2	0.37	YES
5	AKR1B10	AKR1B10	AKR1B10	1331	0.18	0.41	YES
6	ALDH2	ALDH2	ALDH2	1675	0.15	0.44	YES
7	ABAT	ABAT	ABAT	1886	0.13	0.47	YES
8	GAD1	GAD1	GAD1	2392	0.11	0.47	YES
9	HADH	HADH	HADH	2434	0.1	0.5	YES
10	BDH1	BDH1	BDH1	2518	0.1	0.53	YES
11	HMGCL	HMGCL	HMGCL	2544	0.099	0.56	YES
12	PDHA1	PDHA1	PDHA1	2564	0.098	0.58	YES
13	ECHS1	ECHS1	ECHS1	2650	0.095	0.61	YES
14	EHHADH	EHHADH	EHHADH	2875	0.087	0.62	YES
15	ACAT2	ACAT2	ACAT2	3041	0.082	0.64	YES
16	HMGCS1	HMGCS1	HMGCS1	3887	0.061	0.61	NO
17	ALDH9A1	ALDH9A1	ALDH9A1	4979	0.041	0.56	NO
18	HADHA	HADHA	HADHA	5174	0.039	0.56	NO
19	PDHB	PDHB	PDHB	5216	0.038	0.57	NO
20	ACAT1	ACAT1	ACAT1	5744	0.03	0.55	NO
21	BDH2	BDH2	BDH2	5829	0.029	0.56	NO
22	L2HGDH	L2HGDH	L2HGDH	5837	0.029	0.57	NO
23	ALDH5A1	ALDH5A1	ALDH5A1	6279	0.024	0.55	NO
24	OXCT2	OXCT2	OXCT2	6885	0.016	0.52	NO
25	ACSM2A	ACSM2A	ACSM2A	7081	0.014	0.52	NO
26	AACS	AACS	AACS	7565	0.0081	0.49	NO
27	ALDH3A2	ALDH3A2	ALDH3A2	8576	-0.0031	0.44	NO
28	ALDH7A1	ALDH7A1	ALDH7A1	10103	-0.023	0.36	NO
29	ALDH1B1	ALDH1B1	ALDH1B1	10432	-0.028	0.36	NO
30	ACSM5	ACSM5	ACSM5	15090	-0.15	0.15	NO
31	OXCT1	OXCT1	OXCT1	15216	-0.15	0.19	NO

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
KEGG CITRATE CYCLE TCA CYCLE	29	genes.ES.table	0.56	1.8	0.032	0.33	0.64	0.72	0.28	0.52	0.097	0.079
KEGG PENTOSE PHOSPHATE PATHWAY	27	genes.ES.table	0.63	1.9	0.0021	0.41	0.38	0.18	0.078	0.17	0	0.096
KEGG FRUCTOSE AND MANNOSE METABOLISM	34	genes.ES.table	0.66	2.1	0	0.18	0.084	0.38	0.11	0.34	0	0.043
KEGG SELENOAMINO ACID METABOLISM	26	genes.ES.table	0.53	1.6	0.022	0.42	0.9	0.42	0.17	0.35	0.22	0.11
KEGG SPHINGOLIPID METABOLISM	39	genes.ES.table	0.56	1.8	0.012	0.33	0.71	0.33	0.1	0.3	0.11	0.08
KEGG PYRUVATE METABOLISM	38	genes.ES.table	0.5	1.7	0.016	0.39	0.88	0.34	0.17	0.28	0.18	0.099
KEGG BUTANOATE METABOLISM	31	genes.ES.table	0.64	1.9	0	0.29	0.46	0.48	0.16	0.41	0	0.067
KEGG AMINOACYL TRNA BIOSYNTHESIS	41	genes.ES.table	0.56	1.9	0.016	0.33	0.45	0.58	0.3	0.41	0	0.075
KEGG BASE EXCISION REPAIR	33	genes.ES.table	0.55	1.8	0.027	0.34	0.7	0.48	0.29	0.34	0.11	0.079
KEGG PEROXISOME	76	genes.ES.table	0.6	2.1	0	0.1	0.094	0.47	0.18	0.39	0	0.025

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SLC27A2	SLC27A2	SLC27A2	338	0.39	0.037	YES
2	FAR2	FAR2	FAR2	427	0.35	0.082	YES
3	NOS2	NOS2	NOS2	493	0.33	0.12	YES
4	ACSL5	ACSL5	ACSL5	521	0.32	0.17	YES
5	AGXT	AGXT	AGXT	570	0.31	0.21	YES
6	BAAT	BAAT	BAAT	588	0.31	0.25	YES
7	EPHX2	EPHX2	EPHX2	1129	0.21	0.25	YES
8	DECR2	DECR2	DECR2	1189	0.2	0.28	YES
9	PEX11A	PEX11A	PEX11A	1344	0.18	0.29	YES
10	PECR	PECR	PECR	1352	0.18	0.32	YES
11	PXMP2	PXMP2	PXMP2	1391	0.18	0.34	YES
12	XDH	XDH	XDH	1449	0.17	0.36	YES
13	PEX11G	PEX11G	PEX11G	1466	0.17	0.38	YES
14	PEX7	PEX7	PEX7	1476	0.17	0.41	YES
15	PHYH	PHYH	PHYH	1556	0.16	0.42	YES
16	IDH1	IDH1	IDH1	1677	0.15	0.44	YES
17	AMACR	AMACR	AMACR	1745	0.14	0.46	YES
18	ABCD3	ABCD3	ABCD3	1914	0.13	0.47	YES
19	NUDT12	NUDT12	NUDT12	2386	0.11	0.46	YES
20	HAO2	HAO2	HAO2	2535	0.099	0.46	YES
21	HMGCL	HMGCL	HMGCL	2544	0.099	0.47	YES
22	ACAA1	ACAA1	ACAA1	2597	0.096	0.48	YES
23	GSTK1	GSTK1	GSTK1	2621	0.095	0.5	YES
24	SCP2	SCP2	SCP2	2660	0.094	0.51	YES
25	HACL1	HACL1	HACL1	2672	0.094	0.52	YES
26	ACOT8	ACOT8	ACOT8	2715	0.092	0.53	YES
27	EHHADH	EHHADH	EHHADH	2875	0.087	0.54	YES
28	IDH2	IDH2	IDH2	2934	0.084	0.54	YES
29	MLYCD	MLYCD	MLYCD	3068	0.081	0.55	YES
30	PIPOX	PIPOX	PIPOX	3112	0.08	0.56	YES
31	ACOX1	ACOX1	ACOX1	3146	0.079	0.57	YES
32	PEX1	PEX1	PEX1	3300	0.075	0.57	YES
33	PEX16	PEX16	PEX16	3356	0.073	0.58	YES
34	ACOX2	ACOX2	ACOX2	3393	0.072	0.58	YES
35	CAT	CAT	CAT	3431	0.071	0.59	YES
36	PXMP4	PXMP4	PXMP4	3466	0.07	0.6	YES
37	PEX11B	PEX11B	PEX11B	3698	0.065	0.6	NO
38	HSD17B4	HSD17B4	HSD17B4	3829	0.063	0.6	NO
39	SOD1	SOD1	SOD1	4096	0.057	0.59	NO
40	ABCD1	ABCD1	ABCD1	4147	0.056	0.6	NO
41	PEX2	PEX2	PEX2	4394	0.051	0.59	NO
42	GNPAT	GNPAT	GNPAT	4617	0.047	0.59	NO
43	DAO	DAO	DAO	4837	0.044	0.58	NO
44	ABCD4	ABCD4	ABCD4	4849	0.043	0.59	NO
45	CRAT	CRAT	CRAT	4877	0.043	0.59	NO
46	PEX6	PEX6	PEX6	5410	0.035	0.57	NO
47	PRDX5	PRDX5	PRDX5	5420	0.035	0.57	NO
48	ACSL3	ACSL3	ACSL3	5455	0.034	0.57	NO
49	FAR1	FAR1	FAR1	5958	0.028	0.55	NO
50	PRDX1	PRDX1	PRDX1	6220	0.024	0.54	NO
51	PEX13	PEX13	PEX13	6499	0.02	0.53	NO
52	ECH1	ECH1	ECH1	6915	0.015	0.51	NO
53	PEX14	PEX14	PEX14	7030	0.014	0.5	NO
54	AGPS	AGPS	AGPS	7253	0.012	0.49	NO
55	PMVK	PMVK	PMVK	7422	0.01	0.49	NO
56	PEX26	PEX26	PEX26	7501	0.009	0.48	NO
57	MVK	MVK	MVK	7859	0.0049	0.46	NO
58	ACOX3	ACOX3	ACOX3	8505	-0.0023	0.43	NO
59	PEX3	PEX3	PEX3	8968	-0.0084	0.41	NO
60	PEX5	PEX5	PEX5	8984	-0.0086	0.41	NO
61	ACSL4	ACSL4	ACSL4	9187	-0.011	0.4	NO
62	PEX10	PEX10	PEX10	9249	-0.012	0.4	NO
63	SLC25A17	SLC25A17	SLC25A17	9999	-0.021	0.36	NO
64	DHRS4	DHRS4	DHRS4	10017	-0.021	0.36	NO
65	PEX19	PEX19	PEX19	10034	-0.022	0.36	NO
66	PEX12	PEX12	PEX12	10798	-0.033	0.33	NO
67	ACSL6	ACSL6	ACSL6	10820	-0.034	0.33	NO
68	NUDT19	NUDT19	NUDT19	11045	-0.037	0.32	NO
69	DDO	DDO	DDO	11132	-0.039	0.32	NO
70	MPV17L	MPV17L	MPV17L	11156	-0.039	0.33	NO
71	MPV17	MPV17	MPV17	11439	-0.044	0.32	NO
72	SOD2	SOD2	SOD2	12096	-0.054	0.29	NO
73	PAOX	PAOX	PAOX	12331	-0.059	0.29	NO
74	ACSL1	ACSL1	ACSL1	14380	-0.12	0.2	NO
75	ABCD2	ABCD2	ABCD2	14754	-0.13	0.19	NO
76	CROT	CROT	CROT	14951	-0.14	0.2	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MARS2	MARS2	MARS2	1816	0.14	-0.026	YES
2	NARS2	NARS2	NARS2	2618	0.095	-0.02	YES
3	DARS2	DARS2	DARS2	2698	0.093	0.024	YES
4	AIMP2	AIMP2	AIMP2	2707	0.092	0.071	YES
5	QARS	QARS	QARS	2970	0.084	0.1	YES
6	PPA1	PPA1	PPA1	3159	0.079	0.13	YES
7	PPA2	PPA2	PPA2	3168	0.079	0.17	YES
8	AARS2	AARS2	AARS2	3232	0.077	0.21	YES
9	PARS2	PARS2	PARS2	3453	0.07	0.23	YES
10	FARSB	FARSB	FARSB	3638	0.066	0.26	YES
11	WARS2	WARS2	WARS2	3810	0.063	0.28	YES
12	AIMP1	AIMP1	AIMP1	3837	0.062	0.31	YES
13	NARS	NARS	NARS	3897	0.061	0.34	YES
14	EEF1E1	EEF1E1	EEF1E1	3927	0.06	0.37	YES
15	CARS2	CARS2	CARS2	4240	0.054	0.38	YES
16	EARS2	EARS2	EARS2	4305	0.052	0.4	YES
17	LARS2	LARS2	LARS2	4337	0.052	0.43	YES
18	IARS2	IARS2	IARS2	4338	0.052	0.46	YES
19	TARS2	TARS2	TARS2	4340	0.052	0.48	YES
20	RARS	RARS	RARS	4411	0.051	0.5	YES
21	SARS2	SARS2	SARS2	4418	0.05	0.53	YES
22	VARS	VARS	VARS	4492	0.049	0.55	YES
23	HARS2	HARS2	HARS2	4604	0.047	0.57	YES
24	EPRS	EPRS	EPRS	4766	0.045	0.58	YES
25	VARS2	VARS2	VARS2	4783	0.045	0.61	YES
26	GARS	GARS	GARS	5440	0.034	0.59	NO
27	FARSA	FARSA	FARSA	5470	0.034	0.61	NO
28	CARS	CARS	CARS	6460	0.021	0.56	NO
29	KARS	KARS	KARS	6850	0.016	0.55	NO
30	YARS2	YARS2	YARS2	7079	0.014	0.55	NO
31	YARS	YARS	YARS	7123	0.013	0.55	NO
32	RARS2	RARS2	RARS2	7316	0.011	0.55	NO
33	IARS	IARS	IARS	7456	0.0095	0.54	NO
34	SARS	SARS	SARS	7767	0.0058	0.53	NO
35	MARS	MARS	MARS	7898	0.0043	0.52	NO
36	TARS	TARS	TARS	8335	-0.00036	0.5	NO
37	HARS	HARS	HARS	8617	-0.0037	0.49	NO
38	FARS2	FARS2	FARS2	8908	-0.0077	0.48	NO
39	AARS	AARS	AARS	9144	-0.01	0.47	NO
40	LARS	LARS	LARS	9305	-0.012	0.47	NO
41	DARS	DARS	DARS	10477	-0.028	0.42	NO
42	WARS	WARS	WARS	11341	-0.042	0.4	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SUCLG2	SUCLG2	SUCLG2	1419	0.17	-0.05	YES
2	IDH1	IDH1	IDH1	1677	0.15	-0.042	YES
3	SUCLG1	SUCLG1	SUCLG1	2024	0.12	-0.042	YES
4	ATP5G1	ATP5G1	ATP5G1	2205	0.11	-0.035	YES
5	COX5A	COX5A	COX5A	2431	0.1	-0.032	YES
6	CYCS	CYCS	CYCS	2525	0.1	-0.022	YES
7	PDHA1	PDHA1	PDHA1	2564	0.098	-0.0091	YES
8	ETFDH	ETFDH	ETFDH	2657	0.094	-0.000078	YES
9	CYC1	CYC1	CYC1	2770	0.09	0.0072	YES
10	UQCRHL	UQCRHL	UQCRHL	2777	0.09	0.02	YES
11	ETFA	ETFA	ETFA	2889	0.086	0.027	YES
12	IDH2	IDH2	IDH2	2934	0.084	0.037	YES
13	UQCRFS1	UQCRFS1	UQCRFS1	2966	0.084	0.048	YES
14	D2HGDH	D2HGDH	D2HGDH	3047	0.082	0.056	YES
15	NDUFA1	NDUFA1	NDUFA1	3063	0.082	0.067	YES
16	NDUFS2	NDUFS2	NDUFS2	3081	0.081	0.078	YES
17	NDUFA3	NDUFA3	NDUFA3	3133	0.08	0.087	YES
18	UQCRQ	UQCRQ	UQCRQ	3158	0.079	0.098	YES
19	NDUFA2	NDUFA2	NDUFA2	3172	0.078	0.11	YES
20	UQCRH	UQCRH	UQCRH	3206	0.078	0.12	YES
21	NDUFA9	NDUFA9	NDUFA9	3215	0.077	0.13	YES
22	COX7B	COX7B	COX7B	3254	0.076	0.14	YES
23	NDUFC2	NDUFC2	NDUFC2	3305	0.075	0.15	YES
24	NDUFA4	NDUFA4	NDUFA4	3341	0.074	0.16	YES
25	NDUFS3	NDUFS3	NDUFS3	3342	0.074	0.17	YES
26	COX5B	COX5B	COX5B	3345	0.074	0.18	YES
27	COX6A1	COX6A1	COX6A1	3360	0.073	0.19	YES
28	NDUFV2	NDUFV2	NDUFV2	3387	0.072	0.2	YES
29	SDHB	SDHB	SDHB	3511	0.069	0.2	YES
30	ETFB	ETFB	ETFB	3553	0.068	0.21	YES
31	COX6C	COX6C	COX6C	3590	0.067	0.22	YES
32	ATP5F1	ATP5F1	ATP5F1	3594	0.067	0.23	YES
33	NDUFA7	NDUFA7	NDUFA7	3616	0.067	0.24	YES
34	SDHA	SDHA	SDHA	3625	0.067	0.24	YES
35	ATP5I	ATP5I	ATP5I	3630	0.067	0.26	YES
36	IDH3A	IDH3A	IDH3A	3647	0.066	0.26	YES
37	UQCRC1	UQCRC1	UQCRC1	3659	0.066	0.27	YES
38	ATP5J2	ATP5J2	ATP5J2	3707	0.065	0.28	YES
39	NDUFA5	NDUFA5	NDUFA5	3740	0.064	0.29	YES
40	NDUFB3	NDUFB3	NDUFB3	3762	0.064	0.3	YES
41	UQCRC2	UQCRC2	UQCRC2	3764	0.064	0.31	YES
42	COX6B1	COX6B1	COX6B1	3782	0.064	0.31	YES
43	NDUFB2	NDUFB2	NDUFB2	3789	0.063	0.32	YES
44	ATP5B	ATP5B	ATP5B	3824	0.063	0.33	YES
45	ATP5C1	ATP5C1	ATP5C1	3835	0.062	0.34	YES
46	NDUFB6	NDUFB6	NDUFB6	3847	0.062	0.35	YES
47	NDUFAB1	NDUFAB1	NDUFAB1	3848	0.062	0.36	YES
48	FH	FH	FH	3912	0.061	0.36	YES
49	SDHD	SDHD	SDHD	3924	0.06	0.37	YES
50	NDUFS1	NDUFS1	NDUFS1	3926	0.06	0.38	YES
51	NDUFV1	NDUFV1	NDUFV1	3932	0.06	0.39	YES
52	NDUFB9	NDUFB9	NDUFB9	3937	0.06	0.4	YES
53	IDH3B	IDH3B	IDH3B	4019	0.058	0.4	YES
54	NDUFA10	NDUFA10	NDUFA10	4112	0.057	0.4	YES
55	ATP5L	ATP5L	ATP5L	4155	0.056	0.41	YES
56	ATP5D	ATP5D	ATP5D	4219	0.054	0.42	YES
57	ATP5O	ATP5O	ATP5O	4241	0.054	0.42	YES
58	NDUFC1	NDUFC1	NDUFC1	4262	0.054	0.43	YES
59	COX8A	COX8A	COX8A	4269	0.053	0.44	YES
60	COX4I1	COX4I1	COX4I1	4276	0.053	0.44	YES
61	COX7C	COX7C	COX7C	4304	0.052	0.45	YES
62	SUCLA2	SUCLA2	SUCLA2	4479	0.049	0.45	YES
63	DLD	DLD	DLD	4506	0.049	0.46	YES
64	MDH2	MDH2	MDH2	4534	0.048	0.46	YES
65	UQCRB	UQCRB	UQCRB	4569	0.048	0.47	YES
66	PDK4	PDK4	PDK4	4583	0.048	0.47	YES
67	NDUFS6	NDUFS6	NDUFS6	4687	0.046	0.47	YES
68	COX7A2L	COX7A2L	COX7A2L	4697	0.046	0.48	YES
69	DLAT	DLAT	DLAT	4795	0.044	0.48	YES
70	IDH3G	IDH3G	IDH3G	4796	0.044	0.49	YES
71	PDHX	PDHX	PDHX	4925	0.042	0.49	YES
72	SLC16A1	SLC16A1	SLC16A1	4953	0.042	0.49	YES
73	ATP5E	ATP5E	ATP5E	5041	0.041	0.49	YES
74	SDHC	SDHC	SDHC	5055	0.041	0.5	YES
75	NDUFB1	NDUFB1	NDUFB1	5129	0.04	0.5	YES
76	UQCR11	UQCR11	UQCR11	5130	0.04	0.51	YES
77	NDUFS7	NDUFS7	NDUFS7	5140	0.039	0.51	YES
78	NDUFA12	NDUFA12	NDUFA12	5143	0.039	0.52	YES
79	BSG	BSG	BSG	5208	0.038	0.52	YES
80	PDHB	PDHB	PDHB	5216	0.038	0.53	YES
81	NDUFA6	NDUFA6	NDUFA6	5222	0.038	0.53	YES
82	NDUFA8	NDUFA8	NDUFA8	5265	0.038	0.53	YES
83	NDUFB8	NDUFB8	NDUFB8	5429	0.035	0.53	YES
84	ATP5A1	ATP5A1	ATP5A1	5473	0.034	0.53	YES
85	ACO2	ACO2	ACO2	5494	0.034	0.54	YES
86	NDUFA13	NDUFA13	NDUFA13	5522	0.034	0.54	YES
87	L2HGDH	L2HGDH	L2HGDH	5837	0.029	0.53	NO
88	CS	CS	CS	5876	0.029	0.53	NO
89	NDUFB10	NDUFB10	NDUFB10	5999	0.027	0.53	NO
90	PDK2	PDK2	PDK2	6012	0.027	0.53	NO
91	UCP2	UCP2	UCP2	6106	0.026	0.53	NO
92	ATP5H	ATP5H	ATP5H	6264	0.024	0.52	NO
93	PDP2	PDP2	PDP2	6458	0.021	0.52	NO
94	ATP5J	ATP5J	ATP5J	6543	0.02	0.52	NO
95	NNT	NNT	NNT	6751	0.017	0.51	NO
96	NDUFS8	NDUFS8	NDUFS8	6809	0.017	0.51	NO
97	NDUFB7	NDUFB7	NDUFB7	6815	0.017	0.51	NO
98	DLST	DLST	DLST	6997	0.014	0.5	NO
99	NDUFS5	NDUFS5	NDUFS5	7095	0.013	0.5	NO
100	OGDH	OGDH	OGDH	7098	0.013	0.5	NO
101	SLC16A3	SLC16A3	SLC16A3	7140	0.013	0.5	NO
102	NDUFB4	NDUFB4	NDUFB4	7296	0.011	0.49	NO
103	NDUFB5	NDUFB5	NDUFB5	8091	0.0024	0.45	NO
104	LDHA	LDHA	LDHA	8564	-0.003	0.43	NO
105	PDP1	PDP1	PDP1	8868	-0.0071	0.41	NO
106	NDUFV3	NDUFV3	NDUFV3	9087	-0.0098	0.4	NO
107	NDUFS4	NDUFS4	NDUFS4	9120	-0.01	0.4	NO
108	SLC16A8	SLC16A8	SLC16A8	9279	-0.012	0.39	NO
109	NDUFA11	NDUFA11	NDUFA11	9990	-0.021	0.36	NO
110	PDK1	PDK1	PDK1	10272	-0.026	0.35	NO
111	PDPR	PDPR	PDPR	11526	-0.045	0.29	NO
112	PDK3	PDK3	PDK3	11536	-0.045	0.29	NO
113	UCP3	UCP3	UCP3	12396	-0.061	0.26	NO
114	LDHB	LDHB	LDHB	14955	-0.14	0.14	NO
115	ADHFE1	ADHFE1	ADHFE1	18212	-0.42	0.028	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TPK1	TPK1	TPK1	395	0.36	0.065	YES
2	SLC19A3	SLC19A3	SLC19A3	505	0.33	0.14	YES
3	PANK1	PANK1	PANK1	989	0.23	0.16	YES
4	SLC23A1	SLC23A1	SLC23A1	1099	0.21	0.21	YES
5	GSTO2	GSTO2	GSTO2	1280	0.19	0.24	YES
6	RFK	RFK	RFK	1575	0.16	0.26	YES
7	MOCOS	MOCOS	MOCOS	1705	0.15	0.29	YES
8	QPRT	QPRT	QPRT	1895	0.13	0.31	YES
9	CYB5A	CYB5A	CYB5A	1932	0.13	0.34	YES
10	SLC19A1	SLC19A1	SLC19A1	1959	0.13	0.37	YES
11	ENPP1	ENPP1	ENPP1	1978	0.13	0.4	YES
12	NMNAT1	NMNAT1	NMNAT1	2380	0.11	0.4	YES
13	SLC5A6	SLC5A6	SLC5A6	2493	0.1	0.42	YES
14	DHFR	DHFR	DHFR	2515	0.1	0.44	YES
15	PPCS	PPCS	PPCS	3340	0.074	0.41	YES
16	SLC19A2	SLC19A2	SLC19A2	3513	0.069	0.42	YES
17	PANK3	PANK3	PANK3	3576	0.068	0.43	YES
18	PPCDC	PPCDC	PPCDC	3701	0.065	0.44	YES
19	NADK	NADK	NADK	3720	0.065	0.46	YES
20	NFS1	NFS1	NFS1	3942	0.06	0.46	YES
21	SHMT1	SHMT1	SHMT1	3950	0.06	0.47	YES
22	GPHN	GPHN	GPHN	4026	0.058	0.48	YES
23	PNPO	PNPO	PNPO	4497	0.049	0.47	YES
24	PDXK	PDXK	PDXK	4683	0.046	0.47	YES
25	MTHFD1	MTHFD1	MTHFD1	4776	0.045	0.48	YES
26	MTHFR	MTHFR	MTHFR	4805	0.044	0.48	YES
27	COASY	COASY	COASY	4924	0.042	0.49	YES
28	MOCS3	MOCS3	MOCS3	5005	0.041	0.49	YES
29	FPGS	FPGS	FPGS	5209	0.038	0.49	NO
30	SLC25A16	SLC25A16	SLC25A16	5428	0.035	0.49	NO
31	SLC46A1	SLC46A1	SLC46A1	5618	0.032	0.48	NO
32	SLC25A32	SLC25A32	SLC25A32	5951	0.028	0.47	NO
33	FLAD1	FLAD1	FLAD1	5975	0.028	0.48	NO
34	FASN	FASN	FASN	6973	0.015	0.43	NO
35	GSTO1	GSTO1	GSTO1	7599	0.0078	0.4	NO
36	MOCS2	MOCS2	MOCS2	7688	0.0067	0.39	NO
37	NADSYN1	NADSYN1	NADSYN1	8192	0.0012	0.37	NO
38	THTPA	THTPA	THTPA	8891	-0.0074	0.33	NO
39	NAMPT	NAMPT	NAMPT	10276	-0.026	0.26	NO
40	PANK2	PANK2	PANK2	10390	-0.027	0.26	NO
41	AASDHPPT	AASDHPPT	AASDHPPT	10926	-0.035	0.24	NO
42	PANK4	PANK4	PANK4	11134	-0.039	0.24	NO
43	ACP5	ACP5	ACP5	11646	-0.047	0.22	NO
44	NMNAT2	NMNAT2	NMNAT2	12313	-0.059	0.2	NO
45	SLC2A3	SLC2A3	SLC2A3	12837	-0.071	0.19	NO
46	NMNAT3	NMNAT3	NMNAT3	12843	-0.071	0.21	NO
47	CYB5R3	CYB5R3	CYB5R3	12915	-0.073	0.22	NO
48	MOCS1	MOCS1	MOCS1	13997	-0.1	0.19	NO
49	SLC23A2	SLC23A2	SLC23A2	14622	-0.13	0.18	NO
50	SLC2A1	SLC2A1	SLC2A1	15201	-0.15	0.19	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PCK1	PCK1	PCK1	290	0.41	0.16	YES
2	SUCLG2	SUCLG2	SUCLG2	1419	0.17	0.17	YES
3	PCK2	PCK2	PCK2	1653	0.15	0.22	YES
4	IDH1	IDH1	IDH1	1677	0.15	0.28	YES
5	SUCLG1	SUCLG1	SUCLG1	2024	0.12	0.32	YES
6	ACO1	ACO1	ACO1	2265	0.11	0.35	YES
7	PDHA1	PDHA1	PDHA1	2564	0.098	0.38	YES
8	IDH2	IDH2	IDH2	2934	0.084	0.39	YES
9	SDHB	SDHB	SDHB	3511	0.069	0.39	YES
10	SDHA	SDHA	SDHA	3625	0.067	0.41	YES
11	IDH3A	IDH3A	IDH3A	3647	0.066	0.44	YES
12	FH	FH	FH	3912	0.061	0.45	YES
13	SDHD	SDHD	SDHD	3924	0.06	0.48	YES
14	IDH3B	IDH3B	IDH3B	4019	0.058	0.5	YES
15	SUCLA2	SUCLA2	SUCLA2	4479	0.049	0.49	YES
16	DLD	DLD	DLD	4506	0.049	0.51	YES
17	MDH2	MDH2	MDH2	4534	0.048	0.53	YES
18	DLAT	DLAT	DLAT	4795	0.044	0.53	YES
19	IDH3G	IDH3G	IDH3G	4796	0.044	0.55	YES
20	SDHC	SDHC	SDHC	5055	0.041	0.56	YES
21	PDHB	PDHB	PDHB	5216	0.038	0.56	YES
22	ACO2	ACO2	ACO2	5494	0.034	0.56	NO
23	CS	CS	CS	5876	0.029	0.55	NO
24	DLST	DLST	DLST	6997	0.014	0.5	NO
25	OGDH	OGDH	OGDH	7098	0.013	0.5	NO
26	ACLY	ACLY	ACLY	7196	0.012	0.5	NO
27	MDH1	MDH1	MDH1	7505	0.0089	0.49	NO
28	PC	PC	PC	14669	-0.13	0.16	NO
29	OGDHL	OGDHL	OGDHL	14946	-0.14	0.2	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	GPD1	GPD1	GPD1	30	0.63	0.057	YES
2	SLC44A4	SLC44A4	SLC44A4	85	0.55	0.1	YES
3	PLA2G10	PLA2G10	PLA2G10	157	0.49	0.15	YES
4	ACHE	ACHE	ACHE	356	0.38	0.17	YES
5	SLC44A3	SLC44A3	SLC44A3	412	0.36	0.2	YES
6	PLA2G4F	PLA2G4F	PLA2G4F	637	0.29	0.22	YES
7	DGAT2	DGAT2	DGAT2	785	0.26	0.23	YES
8	DGAT1	DGAT1	DGAT1	871	0.24	0.25	YES
9	LPIN2	LPIN2	LPIN2	905	0.24	0.27	YES
10	PLA2G2A	PLA2G2A	PLA2G2A	907	0.24	0.29	YES
11	PLA2G16	PLA2G16	PLA2G16	935	0.24	0.31	YES
12	PLBD1	PLBD1	PLBD1	1028	0.22	0.33	YES
13	MBOAT1	MBOAT1	MBOAT1	1154	0.2	0.34	YES
14	CHKA	CHKA	CHKA	1180	0.2	0.36	YES
15	CDS1	CDS1	CDS1	1230	0.19	0.37	YES
16	AGPAT2	AGPAT2	AGPAT2	1267	0.19	0.39	YES
17	CHPT1	CHPT1	CHPT1	1372	0.18	0.4	YES
18	LPCAT4	LPCAT4	LPCAT4	1376	0.18	0.42	YES
19	AGPAT9	AGPAT9	AGPAT9	1393	0.18	0.43	YES
20	PCYT2	PCYT2	PCYT2	1465	0.17	0.44	YES
21	ETNK1	ETNK1	ETNK1	1482	0.17	0.46	YES
22	CRLS1	CRLS1	CRLS1	1824	0.14	0.45	YES
23	LPIN3	LPIN3	LPIN3	1940	0.13	0.46	YES
24	PLA2G2F	PLA2G2F	PLA2G2F	1952	0.13	0.47	YES
25	PLA2G4A	PLA2G4A	PLA2G4A	2085	0.12	0.47	YES
26	GPD1L	GPD1L	GPD1L	2096	0.12	0.48	YES
27	MGLL	MGLL	MGLL	2196	0.12	0.49	YES
28	AGPAT5	AGPAT5	AGPAT5	2806	0.089	0.47	NO
29	LPCAT3	LPCAT3	LPCAT3	2840	0.088	0.47	NO
30	PNPLA2	PNPLA2	PNPLA2	2885	0.087	0.48	NO
31	GNPAT	GNPAT	GNPAT	4617	0.047	0.39	NO
32	CEPT1	CEPT1	CEPT1	4930	0.042	0.38	NO
33	EPT1	EPT1	EPT1	5108	0.04	0.37	NO
34	MBOAT7	MBOAT7	MBOAT7	5171	0.039	0.37	NO
35	HADHA	HADHA	HADHA	5174	0.039	0.37	NO
36	AGPAT6	AGPAT6	AGPAT6	5253	0.038	0.37	NO
37	PLA2G1B	PLA2G1B	PLA2G1B	5626	0.032	0.36	NO
38	TAZ	TAZ	TAZ	5655	0.032	0.36	NO
39	SLC44A1	SLC44A1	SLC44A1	6031	0.027	0.34	NO
40	PTDSS2	PTDSS2	PTDSS2	6071	0.026	0.34	NO
41	PLA2G12A	PLA2G12A	PLA2G12A	6340	0.023	0.33	NO
42	AGPAT1	AGPAT1	AGPAT1	6403	0.022	0.33	NO
43	LPCAT1	LPCAT1	LPCAT1	6514	0.02	0.32	NO
44	LPGAT1	LPGAT1	LPGAT1	6819	0.017	0.31	NO
45	LCLAT1	LCLAT1	LCLAT1	6852	0.016	0.31	NO
46	SLC44A2	SLC44A2	SLC44A2	6976	0.015	0.3	NO
47	PNPLA3	PNPLA3	PNPLA3	7323	0.011	0.28	NO
48	AGPAT3	AGPAT3	AGPAT3	7404	0.01	0.28	NO
49	LPIN1	LPIN1	LPIN1	7455	0.0095	0.28	NO
50	PEMT	PEMT	PEMT	7511	0.0088	0.28	NO
51	PLA2G6	PLA2G6	PLA2G6	7569	0.0081	0.28	NO
52	PTDSS1	PTDSS1	PTDSS1	7702	0.0066	0.27	NO
53	HADHB	HADHB	HADHB	7996	0.0033	0.25	NO
54	GPAT2	GPAT2	GPAT2	8532	-0.0026	0.23	NO
55	GPAM	GPAM	GPAM	9145	-0.01	0.19	NO
56	CDIPT	CDIPT	CDIPT	9797	-0.018	0.16	NO
57	CHKB	CHKB	CHKB	9840	-0.019	0.16	NO
58	CDS2	CDS2	CDS2	10545	-0.029	0.12	NO
59	PLA2G3	PLA2G3	PLA2G3	10732	-0.032	0.12	NO
60	PNPLA8	PNPLA8	PNPLA8	11359	-0.043	0.088	NO
61	PLA2G2D	PLA2G2D	PLA2G2D	11381	-0.043	0.091	NO
62	PLD1	PLD1	PLD1	11444	-0.044	0.092	NO
63	PHOSPHO1	PHOSPHO1	PHOSPHO1	11609	-0.046	0.087	NO
64	PGS1	PGS1	PGS1	11630	-0.047	0.091	NO
65	PLD6	PLD6	PLD6	11892	-0.051	0.081	NO
66	PLD3	PLD3	PLD3	12192	-0.056	0.071	NO
67	PITPNB	PITPNB	PITPNB	12336	-0.06	0.068	NO
68	GPCPD1	GPCPD1	GPCPD1	12855	-0.071	0.047	NO
69	PCYT1A	PCYT1A	PCYT1A	13360	-0.084	0.028	NO
70	LPCAT2	LPCAT2	LPCAT2	13928	-0.1	0.0069	NO
71	PLD2	PLD2	PLD2	14429	-0.12	-0.009	NO
72	PLD4	PLD4	PLD4	14688	-0.13	-0.011	NO
73	MBOAT2	MBOAT2	MBOAT2	14719	-0.13	-0.00051	NO
74	PLA2G4D	PLA2G4D	PLA2G4D	14866	-0.14	0.0042	NO
75	SLC44A5	SLC44A5	SLC44A5	15659	-0.18	-0.022	NO
76	PLA2G4C	PLA2G4C	PLA2G4C	17047	-0.28	-0.071	NO
77	AGPAT4	AGPAT4	AGPAT4	17208	-0.29	-0.053	NO
78	PLA2G5	PLA2G5	PLA2G5	17777	-0.35	-0.05	NO
79	ETNK2	ETNK2	ETNK2	18474	-0.5	-0.042	NO
80	PCYT1B	PCYT1B	PCYT1B	18649	-0.59	0.004	NO

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
KEGG PURINE METABOLISM	155	genes.ES.table	0.44	1.8	0.002	0.17	0.6	0.19	0.15	0.17	0.045	0.034
KEGG TYROSINE METABOLISM	41	genes.ES.table	0.48	1.4	0.094	0.21	1	0.24	0.12	0.21	0.16	0.001
KEGG TRYPTOPHAN METABOLISM	39	genes.ES.table	0.52	1.5	0.024	0.14	0.99	0.26	0.19	0.21	0.091	0.001
KEGG GLYCOSAMINOGLYCAN BIOSYNTHESIS HEPARAN SULFATE	26	genes.ES.table	0.55	1.5	0.037	0.14	0.99	0.31	0.22	0.24	0.083	0.001
KEGG ABC TRANSPORTERS	44	genes.ES.table	0.53	1.4	0.057	0.18	1	0.2	0.081	0.19	0.12	0.001
KEGG MAPK SIGNALING PATHWAY	257	genes.ES.table	0.48	1.8	0.0042	0.15	0.66	0.31	0.22	0.24	0.045	0.032
KEGG ERBB SIGNALING PATHWAY	87	genes.ES.table	0.38	1.5	0.038	0.15	1	0.18	0.16	0.16	0.094	0.001
KEGG CALCIUM SIGNALING PATHWAY	176	genes.ES.table	0.62	1.7	0	0.13	0.76	0.49	0.22	0.39	0.043	0.024
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION	243	genes.ES.table	0.53	1.4	0.095	0.2	1	0.53	0.25	0.4	0.14	0.001
KEGG CHEMOKINE SIGNALING PATHWAY	185	genes.ES.table	0.57	1.6	0.028	0.12	0.94	0.47	0.26	0.35	0.06	0.007

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	IGF1	IGF1	IGF1	84	0.82	0.12	YES
2	FIGF	FIGF	FIGF	736	0.53	0.17	YES
3	PIK3CG	PIK3CG	PIK3CG	947	0.49	0.23	YES
4	PRKAA2	PRKAA2	PRKAA2	1283	0.43	0.28	YES
5	PIK3R5	PIK3R5	PIK3R5	1288	0.43	0.35	YES
6	AKT3	AKT3	AKT3	1433	0.41	0.4	YES
7	VEGFC	VEGFC	VEGFC	1615	0.39	0.45	YES
8	RPS6KA6	RPS6KA6	RPS6KA6	1749	0.36	0.5	YES
9	CAB39L	CAB39L	CAB39L	2075	0.32	0.53	YES
10	PIK3CD	PIK3CD	PIK3CD	2911	0.24	0.53	YES
11	RPS6KA2	RPS6KA2	RPS6KA2	3385	0.2	0.53	YES
12	PIK3R1	PIK3R1	PIK3R1	3717	0.18	0.54	YES
13	VEGFB	VEGFB	VEGFB	3916	0.16	0.56	YES
14	ULK2	ULK2	ULK2	4011	0.16	0.57	YES
15	PIK3R3	PIK3R3	PIK3R3	4769	0.12	0.55	NO
16	PGF	PGF	PGF	6708	0.055	0.46	NO
17	AKT2	AKT2	AKT2	7538	0.039	0.42	NO
18	EIF4B	EIF4B	EIF4B	7692	0.036	0.42	NO
19	STRADA	STRADA	STRADA	7717	0.036	0.42	NO
20	TSC2	TSC2	TSC2	8168	0.028	0.4	NO
21	RPS6	RPS6	RPS6	8253	0.027	0.4	NO
22	PDPK1	PDPK1	PDPK1	8498	0.022	0.39	NO
23	RPS6KA3	RPS6KA3	RPS6KA3	8635	0.021	0.39	NO
24	PIK3CA	PIK3CA	PIK3CA	8702	0.02	0.39	NO
25	RPTOR	RPTOR	RPTOR	9487	0.0075	0.35	NO
26	ULK1	ULK1	ULK1	9741	0.0039	0.33	NO
27	BRAF	BRAF	BRAF	9777	0.0036	0.33	NO
28	TSC1	TSC1	TSC1	9862	0.0024	0.33	NO
29	MAPK3	MAPK3	MAPK3	10227	-0.0026	0.31	NO
30	RICTOR	RICTOR	RICTOR	10240	-0.0028	0.31	NO
31	MAPK1	MAPK1	MAPK1	10363	-0.0046	0.3	NO
32	MLST8	MLST8	MLST8	10365	-0.0046	0.3	NO
33	PRKAA1	PRKAA1	PRKAA1	10399	-0.0051	0.3	NO
34	AKT1	AKT1	AKT1	10625	-0.0084	0.29	NO
35	STK11	STK11	STK11	11118	-0.015	0.27	NO
36	RHEB	RHEB	RHEB	11220	-0.016	0.26	NO
37	RPS6KB1	RPS6KB1	RPS6KB1	12090	-0.027	0.22	NO
38	MTOR	MTOR	MTOR	12188	-0.028	0.22	NO
39	DDIT4	DDIT4	DDIT4	12375	-0.031	0.22	NO
40	EIF4E2	EIF4E2	EIF4E2	12668	-0.035	0.2	NO
41	CAB39	CAB39	CAB39	12799	-0.037	0.2	NO
42	PIK3R2	PIK3R2	PIK3R2	13432	-0.045	0.18	NO
43	HIF1A	HIF1A	HIF1A	13490	-0.046	0.18	NO
44	PIK3CB	PIK3CB	PIK3CB	14734	-0.066	0.12	NO
45	EIF4E	EIF4E	EIF4E	14750	-0.067	0.14	NO
46	ULK3	ULK3	ULK3	14873	-0.069	0.14	NO
47	RPS6KB2	RPS6KB2	RPS6KB2	15386	-0.08	0.12	NO
48	RPS6KA1	RPS6KA1	RPS6KA1	15658	-0.087	0.12	NO
49	EIF4EBP1	EIF4EBP1	EIF4EBP1	16737	-0.12	0.084	NO
50	VEGFA	VEGFA	VEGFA	17125	-0.15	0.086	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	AGTR1	AGTR1	AGTR1	100	0.8	0.22	YES
2	PRKCB	PRKCB	PRKCB	274	0.68	0.4	YES
3	MEF2C	MEF2C	MEF2C	1161	0.45	0.48	YES
4	AGT	AGT	AGT	1976	0.34	0.53	YES
5	MEF2A	MEF2A	MEF2A	4733	0.12	0.42	NO
6	MEF2D	MEF2D	MEF2D	4835	0.12	0.45	NO
7	PRKCA	PRKCA	PRKCA	5424	0.093	0.44	NO
8	JUN	JUN	JUN	6109	0.072	0.42	NO
9	GNAQ	GNAQ	GNAQ	6639	0.057	0.41	NO
10	ELK1	ELK1	ELK1	7066	0.048	0.4	NO
11	CALM3	CALM3	CALM3	7092	0.047	0.41	NO
12	ATF2	ATF2	ATF2	7412	0.041	0.41	NO
13	CALM1	CALM1	CALM1	7817	0.034	0.4	NO
14	SOS1	SOS1	SOS1	8071	0.029	0.39	NO
15	MAP3K1	MAP3K1	MAP3K1	9051	0.014	0.34	NO
16	GRB2	GRB2	GRB2	9073	0.014	0.34	NO
17	PTK2B	PTK2B	PTK2B	9139	0.013	0.34	NO
18	CALM2	CALM2	CALM2	9674	0.0049	0.32	NO
19	RAF1	RAF1	RAF1	10029	0.0001	0.3	NO
20	MAPK3	MAPK3	MAPK3	10227	-0.0026	0.29	NO
21	MAPK1	MAPK1	MAPK1	10363	-0.0046	0.28	NO
22	SHC1	SHC1	SHC1	10732	-0.01	0.27	NO
23	MAPK8	MAPK8	MAPK8	11387	-0.019	0.24	NO
24	MAP2K2	MAP2K2	MAP2K2	11498	-0.02	0.24	NO
25	MAP2K4	MAP2K4	MAP2K4	12946	-0.039	0.17	NO
26	MAP2K1	MAP2K1	MAP2K1	13417	-0.045	0.16	NO
27	RAC1	RAC1	RAC1	13625	-0.048	0.16	NO
28	PTK2	PTK2	PTK2	13919	-0.052	0.16	NO
29	SRC	SRC	SRC	13949	-0.053	0.17	NO
30	PAK1	PAK1	PAK1	14509	-0.062	0.16	NO
31	EGFR	EGFR	EGFR	16365	-0.11	0.091	NO
32	HRAS	HRAS	HRAS	16731	-0.12	0.11	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SLC2A4	SLC2A4	SLC2A4	301	0.67	0.069	YES
2	ADIPOQ	ADIPOQ	ADIPOQ	395	0.63	0.14	YES
3	FABP4	FABP4	FABP4	606	0.56	0.2	YES
4	EBF1	EBF1	EBF1	738	0.53	0.26	YES
5	CD36	CD36	CD36	1274	0.44	0.29	YES
6	SMARCD3	SMARCD3	SMARCD3	1347	0.42	0.34	YES
7	PLIN1	PLIN1	PLIN1	1721	0.37	0.37	YES
8	LPL	LPL	LPL	1743	0.36	0.41	YES
9	EGR2	EGR2	EGR2	1833	0.35	0.45	YES
10	WNT1	WNT1	WNT1	2442	0.28	0.46	YES
11	NR2F2	NR2F2	NR2F2	2463	0.28	0.49	YES
12	LEP	LEP	LEP	3497	0.19	0.46	NO
13	TGFB1	TGFB1	TGFB1	4137	0.15	0.45	NO
14	TBL1X	TBL1X	TBL1X	4542	0.13	0.44	NO
15	PPARGC1A	PPARGC1A	PPARGC1A	4892	0.12	0.44	NO
16	CEBPD	CEBPD	CEBPD	5305	0.098	0.43	NO
17	WNT10B	WNT10B	WNT10B	5379	0.095	0.44	NO
18	MED7	MED7	MED7	5908	0.077	0.42	NO
19	NCOA1	NCOA1	NCOA1	6504	0.061	0.39	NO
20	CREBBP	CREBBP	CREBBP	6771	0.054	0.38	NO
21	MED29	MED29	MED29	6824	0.053	0.39	NO
22	MED13L	MED13L	MED13L	7041	0.048	0.38	NO
23	NCOR1	NCOR1	NCOR1	7603	0.038	0.36	NO
24	MED21	MED21	MED21	7736	0.035	0.36	NO
25	MED22	MED22	MED22	7970	0.031	0.35	NO
26	MED11	MED11	MED11	8166	0.028	0.34	NO
27	PPARG	PPARG	PPARG	8181	0.028	0.34	NO
28	NCOR2	NCOR2	NCOR2	8536	0.022	0.33	NO
29	CDK19	CDK19	CDK19	8775	0.018	0.32	NO
30	NCOA2	NCOA2	NCOA2	9108	0.013	0.3	NO
31	CCND3	CCND3	CCND3	9325	0.0099	0.29	NO
32	MED16	MED16	MED16	9365	0.0091	0.29	NO
33	MED12	MED12	MED12	9496	0.0074	0.28	NO
34	EP300	EP300	EP300	9664	0.0051	0.28	NO
35	ANGPTL4	ANGPTL4	ANGPTL4	9781	0.0035	0.27	NO
36	MED9	MED9	MED9	10109	-0.0008	0.25	NO
37	RELA	RELA	RELA	10208	-0.0024	0.25	NO
38	HDAC3	HDAC3	HDAC3	10224	-0.0026	0.25	NO
39	MED17	MED17	MED17	10276	-0.0033	0.24	NO
40	MED1	MED1	MED1	10344	-0.0042	0.24	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	GNAO1	GNAO1	GNAO1	34	0.9	0.16	YES
2	GLI1	GLI1	GLI1	562	0.57	0.24	YES
3	GNAZ	GNAZ	GNAZ	1406	0.42	0.26	YES
4	GNG2	GNG2	GNG2	1680	0.38	0.32	YES
5	GLI3	GLI3	GLI3	1829	0.35	0.37	YES
6	RAB23	RAB23	RAB23	1903	0.34	0.43	YES
7	GLI2	GLI2	GLI2	2337	0.3	0.46	YES
8	PTCH1	PTCH1	PTCH1	2769	0.25	0.49	YES
9	SMO	SMO	SMO	2851	0.24	0.53	YES
10	GNAI2	GNAI2	GNAI2	4749	0.12	0.45	NO
11	SPOP	SPOP	SPOP	4793	0.12	0.46	NO
12	SUFU	SUFU	SUFU	5122	0.1	0.47	NO
13	SAP30	SAP30	SAP30	5301	0.098	0.48	NO
14	GNAI1	GNAI1	GNAI1	5463	0.092	0.48	NO
15	ARRB2	ARRB2	ARRB2	5534	0.09	0.5	NO
16	PRKACA	PRKACA	PRKACA	5883	0.078	0.49	NO
17	SSPO	SSPO	SSPO	6305	0.066	0.48	NO
18	FOXA2	FOXA2	FOXA2	6555	0.06	0.48	NO
19	CREBBP	CREBBP	CREBBP	6771	0.054	0.48	NO
20	FBXW11	FBXW11	FBXW11	7097	0.047	0.47	NO
21	PIAS1	PIAS1	PIAS1	7684	0.036	0.44	NO
22	SIN3B	SIN3B	SIN3B	7722	0.036	0.45	NO
23	KIF3A	KIF3A	KIF3A	8668	0.02	0.4	NO
24	SHH	SHH	SHH	8810	0.018	0.4	NO
25	IFT172	IFT172	IFT172	9164	0.012	0.38	NO
26	CSNK1G3	CSNK1G3	CSNK1G3	9234	0.011	0.38	NO
27	GNB1	GNB1	GNB1	9380	0.0089	0.37	NO
28	CSNK1D	CSNK1D	CSNK1D	9816	0.0031	0.35	NO
29	RBBP4	RBBP4	RBBP4	9946	0.0011	0.34	NO
30	SAP18	SAP18	SAP18	9973	0.00082	0.34	NO
31	SIN3A	SIN3A	SIN3A	10010	0.00031	0.34	NO
32	CSNK1E	CSNK1E	CSNK1E	10282	-0.0033	0.32	NO
33	RBBP7	RBBP7	RBBP7	10533	-0.0071	0.31	NO
34	AKT1	AKT1	AKT1	10625	-0.0084	0.31	NO
35	CSNK1G2	CSNK1G2	CSNK1G2	11228	-0.017	0.28	NO
36	MTSS1	MTSS1	MTSS1	11566	-0.021	0.26	NO
37	IFT88	IFT88	IFT88	12452	-0.032	0.22	NO
38	CSNK1A1	CSNK1A1	CSNK1A1	12780	-0.037	0.21	NO
39	MAP2K1	MAP2K1	MAP2K1	13417	-0.045	0.19	NO
40	GNAI3	GNAI3	GNAI3	13695	-0.049	0.18	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ADCY5	ADCY5	ADCY5	120	0.79	0.042	YES
2	PDE1A	PDE1A	PDE1A	127	0.78	0.091	YES
3	ADCY2	ADCY2	ADCY2	185	0.74	0.13	YES
4	PDE1B	PDE1B	PDE1B	198	0.73	0.18	YES
5	ADCYAP1	ADCYAP1	ADCYAP1	227	0.71	0.22	YES
6	ADCYAP1R1	ADCYAP1R1	ADCYAP1R1	336	0.65	0.26	YES
7	NTRK1	NTRK1	NTRK1	768	0.52	0.26	YES
8	PRKAR2B	PRKAR2B	PRKAR2B	879	0.5	0.29	YES
9	CAMK4	CAMK4	CAMK4	1069	0.47	0.31	YES
10	MEF2C	MEF2C	MEF2C	1161	0.45	0.33	YES
11	AKT3	AKT3	AKT3	1433	0.41	0.34	YES
12	NGF	NGF	NGF	1445	0.41	0.37	YES
13	ADORA2A	ADORA2A	ADORA2A	1569	0.39	0.39	YES
14	SHC2	SHC2	SHC2	1728	0.37	0.4	YES
15	ADCY4	ADCY4	ADCY4	1858	0.35	0.42	YES
16	SH3GL2	SH3GL2	SH3GL2	2369	0.29	0.41	YES
17	PRKCG	PRKCG	PRKCG	2408	0.29	0.42	YES
18	MAPK11	MAPK11	MAPK11	2806	0.25	0.42	YES
19	ADCY1	ADCY1	ADCY1	3032	0.23	0.42	YES
20	PRKACB	PRKACB	PRKACB	3079	0.23	0.43	YES
21	RPS6KA2	RPS6KA2	RPS6KA2	3385	0.2	0.42	YES
22	PIK3R1	PIK3R1	PIK3R1	3717	0.18	0.42	YES
23	ADCY9	ADCY9	ADCY9	3857	0.17	0.42	YES
24	NTRK2	NTRK2	NTRK2	3907	0.16	0.43	YES
25	IRS2	IRS2	IRS2	4015	0.16	0.43	YES
26	FOXO4	FOXO4	FOXO4	4021	0.16	0.44	YES
27	ITPR2	ITPR2	ITPR2	4023	0.16	0.45	YES
28	SHC3	SHC3	SHC3	4213	0.15	0.45	YES
29	FOXO1	FOXO1	FOXO1	4607	0.13	0.44	YES
30	DUSP3	DUSP3	DUSP3	4636	0.13	0.44	YES
31	DNM1	DNM1	DNM1	4646	0.13	0.45	YES
32	MEF2A	MEF2A	MEF2A	4733	0.12	0.46	YES
33	RAP1A	RAP1A	RAP1A	4751	0.12	0.46	YES
34	CDKN1B	CDKN1B	CDKN1B	5044	0.11	0.45	NO
35	IRS1	IRS1	IRS1	5411	0.094	0.44	NO
36	PRKCA	PRKCA	PRKCA	5424	0.093	0.44	NO
37	RAPGEF1	RAPGEF1	RAPGEF1	5624	0.087	0.44	NO
38	NR4A1	NR4A1	NR4A1	5640	0.087	0.44	NO
39	PRKCE	PRKCE	PRKCE	5652	0.086	0.45	NO
40	RPS6KA5	RPS6KA5	RPS6KA5	5674	0.086	0.45	NO
41	PTEN	PTEN	PTEN	5874	0.078	0.45	NO
42	PRKACA	PRKACA	PRKACA	5883	0.078	0.45	NO
43	DUSP4	DUSP4	DUSP4	6249	0.068	0.44	NO
44	MAPK12	MAPK12	MAPK12	6306	0.066	0.44	NO
45	MAP2K5	MAP2K5	MAP2K5	6586	0.059	0.42	NO
46	PLCG1	PLCG1	PLCG1	6668	0.057	0.42	NO
47	PRKAR2A	PRKAR2A	PRKAR2A	6694	0.056	0.43	NO
48	MAPKAP1	MAPKAP1	MAPKAP1	6743	0.054	0.43	NO
49	ELK1	ELK1	ELK1	7066	0.048	0.41	NO
50	CALM3	CALM3	CALM3	7092	0.047	0.42	NO
51	BAD	BAD	BAD	7494	0.04	0.4	NO
52	AKT2	AKT2	AKT2	7538	0.039	0.4	NO
53	STAT3	STAT3	STAT3	7573	0.038	0.4	NO
54	ADCY6	ADCY6	ADCY6	7627	0.037	0.4	NO
55	ADCY7	ADCY7	ADCY7	7678	0.036	0.4	NO
56	PRKAR1A	PRKAR1A	PRKAR1A	7769	0.035	0.39	NO
57	CALM1	CALM1	CALM1	7817	0.034	0.39	NO
58	AP2A2	AP2A2	AP2A2	7879	0.033	0.39	NO
59	KIDINS220	KIDINS220	KIDINS220	7918	0.032	0.39	NO
60	CASP9	CASP9	CASP9	7954	0.032	0.39	NO
61	CREB1	CREB1	CREB1	8057	0.03	0.39	NO
62	SOS1	SOS1	SOS1	8071	0.029	0.39	NO
63	RHOA	RHOA	RHOA	8123	0.028	0.39	NO
64	TSC2	TSC2	TSC2	8168	0.028	0.39	NO
65	PDPK1	PDPK1	PDPK1	8498	0.022	0.37	NO
66	RPS6KA3	RPS6KA3	RPS6KA3	8635	0.021	0.36	NO
67	PIK3CA	PIK3CA	PIK3CA	8702	0.02	0.36	NO
68	FOXO3	FOXO3	FOXO3	8799	0.018	0.36	NO
69	PRKACG	PRKACG	PRKACG	8877	0.017	0.36	NO
70	GRB2	GRB2	GRB2	9073	0.014	0.34	NO
71	ADCY8	ADCY8	ADCY8	9078	0.014	0.35	NO
72	FRS2	FRS2	FRS2	9246	0.011	0.34	NO
73	PRKAR1B	PRKAR1B	PRKAR1B	9259	0.011	0.34	NO
74	CALM2	CALM2	CALM2	9674	0.0049	0.32	NO
75	THEM4	THEM4	THEM4	9736	0.004	0.31	NO
76	BRAF	BRAF	BRAF	9777	0.0036	0.31	NO
77	MAPKAPK2	MAPKAPK2	MAPKAPK2	9787	0.0034	0.31	NO
78	AP2A1	AP2A1	AP2A1	9914	0.0015	0.3	NO
79	MDM2	MDM2	MDM2	9919	0.0014	0.3	NO
80	AP2B1	AP2B1	AP2B1	9982	0.0007	0.3	NO
81	RAF1	RAF1	RAF1	10029	0.0001	0.3	NO
82	AKT1S1	AKT1S1	AKT1S1	10089	-0.00061	0.3	NO
83	MAPK3	MAPK3	MAPK3	10227	-0.0026	0.29	NO
84	RICTOR	RICTOR	RICTOR	10240	-0.0028	0.29	NO
85	PPP2CB	PPP2CB	PPP2CB	10303	-0.0037	0.28	NO
86	ADCY3	ADCY3	ADCY3	10333	-0.0041	0.28	NO
87	DUSP6	DUSP6	DUSP6	10362	-0.0046	0.28	NO
88	MAPK1	MAPK1	MAPK1	10363	-0.0046	0.28	NO
89	MLST8	MLST8	MLST8	10365	-0.0046	0.28	NO
90	MAPK14	MAPK14	MAPK14	10441	-0.0058	0.28	NO
91	AKT1	AKT1	AKT1	10625	-0.0084	0.27	NO
92	DNAL4	DNAL4	DNAL4	10641	-0.0086	0.27	NO
93	ATF1	ATF1	ATF1	10643	-0.0086	0.27	NO
94	PPP2R1A	PPP2R1A	PPP2R1A	10647	-0.0088	0.27	NO
95	SHC1	SHC1	SHC1	10732	-0.01	0.27	NO
96	GSK3A	GSK3A	GSK3A	10942	-0.013	0.26	NO
97	MAPK7	MAPK7	MAPK7	11217	-0.016	0.24	NO
98	CRK	CRK	CRK	11285	-0.017	0.24	NO
99	MAPKAPK3	MAPKAPK3	MAPKAPK3	11370	-0.018	0.24	NO
100	AP2M1	AP2M1	AP2M1	11428	-0.019	0.23	NO
101	MAP2K2	MAP2K2	MAP2K2	11498	-0.02	0.23	NO
102	CLTA	CLTA	CLTA	12027	-0.026	0.2	NO
103	YWHAB	YWHAB	YWHAB	12084	-0.027	0.2	NO
104	MTOR	MTOR	MTOR	12188	-0.028	0.2	NO
105	RALGDS	RALGDS	RALGDS	12305	-0.03	0.2	NO
106	ADRBK1	ADRBK1	ADRBK1	12436	-0.032	0.19	NO
107	PPP2CA	PPP2CA	PPP2CA	12740	-0.036	0.18	NO
108	KRAS	KRAS	KRAS	12775	-0.037	0.18	NO
109	AP2S1	AP2S1	AP2S1	13055	-0.04	0.16	NO
110	CLTC	CLTC	CLTC	13252	-0.043	0.16	NO
111	RIT1	RIT1	RIT1	13262	-0.043	0.16	NO
112	MAP2K1	MAP2K1	MAP2K1	13417	-0.045	0.15	NO
113	PIK3R2	PIK3R2	PIK3R2	13432	-0.045	0.16	NO
114	PPP2R5D	PPP2R5D	PPP2R5D	13461	-0.046	0.16	NO
115	CHUK	CHUK	CHUK	13617	-0.048	0.15	NO
116	CDKN1A	CDKN1A	CDKN1A	13711	-0.049	0.15	NO
117	PRKCD	PRKCD	PRKCD	13877	-0.052	0.14	NO
118	SRC	SRC	SRC	13949	-0.053	0.14	NO
119	DNM2	DNM2	DNM2	14278	-0.059	0.13	NO
120	RALB	RALB	RALB	14571	-0.064	0.12	NO
121	PIK3CB	PIK3CB	PIK3CB	14734	-0.066	0.11	NO
122	NRAS	NRAS	NRAS	15221	-0.077	0.091	NO
123	PPP2R1B	PPP2R1B	PPP2R1B	15236	-0.077	0.095	NO
124	RPS6KB2	RPS6KB2	RPS6KB2	15386	-0.08	0.092	NO
125	RPS6KA1	RPS6KA1	RPS6KA1	15658	-0.087	0.083	NO
126	RALA	RALA	RALA	15663	-0.087	0.088	NO
127	PHLPP1	PHLPP1	PHLPP1	16059	-0.098	0.073	NO
128	HRAS	HRAS	HRAS	16731	-0.12	0.045	NO
129	DUSP7	DUSP7	DUSP7	17024	-0.14	0.038	NO
130	ITPR3	ITPR3	ITPR3	17147	-0.15	0.04	NO
131	MAPK13	MAPK13	MAPK13	17616	-0.19	0.027	NO
132	CDK1	CDK1	CDK1	18021	-0.24	0.02	NO
133	TRIB3	TRIB3	TRIB3	18330	-0.29	0.021	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	HAND2	HAND2	HAND2	7	0.98	0.11	YES
2	IGF1	IGF1	IGF1	84	0.82	0.2	YES
3	FGF2	FGF2	FGF2	384	0.63	0.25	YES
4	PRKAR2B	PRKAR2B	PRKAR2B	879	0.5	0.28	YES
5	PIK3CG	PIK3CG	PIK3CG	947	0.49	0.34	YES
6	CAMK4	CAMK4	CAMK4	1069	0.47	0.38	YES
7	MEF2C	MEF2C	MEF2C	1161	0.45	0.43	YES
8	NFATC4	NFATC4	NFATC4	1668	0.38	0.44	YES
9	ACTA1	ACTA1	ACTA1	1883	0.35	0.47	YES
10	CTF1	CTF1	CTF1	1968	0.34	0.5	YES
11	AGT	AGT	AGT	1976	0.34	0.54	YES
12	CAMK1G	CAMK1G	CAMK1G	2090	0.32	0.57	YES
13	NFATC2	NFATC2	NFATC2	2305	0.3	0.59	YES
14	CAMK1	CAMK1	CAMK1	2514	0.28	0.62	YES
15	NFATC1	NFATC1	NFATC1	3062	0.23	0.61	YES
16	PRKACB	PRKACB	PRKACB	3079	0.23	0.64	YES
17	PIK3R1	PIK3R1	PIK3R1	3717	0.18	0.62	YES
18	GATA4	GATA4	GATA4	3960	0.16	0.63	YES
19	PPP3CC	PPP3CC	PPP3CC	3981	0.16	0.64	YES
20	EDN1	EDN1	EDN1	4366	0.14	0.64	NO
21	PPP3CB	PPP3CB	PPP3CB	5187	0.1	0.61	NO
22	NKX2-5	NKX2-5	NKX2-5	6407	0.063	0.55	NO
23	PRKAR2A	PRKAR2A	PRKAR2A	6694	0.056	0.54	NO
24	HAND1	HAND1	HAND1	6759	0.054	0.54	NO
25	CREBBP	CREBBP	CREBBP	6771	0.054	0.55	NO
26	CALM3	CALM3	CALM3	7092	0.047	0.54	NO
27	NFATC3	NFATC3	NFATC3	7505	0.04	0.52	NO
28	PRKAR1A	PRKAR1A	PRKAR1A	7769	0.035	0.51	NO
29	CALM1	CALM1	CALM1	7817	0.034	0.51	NO
30	PPP3CA	PPP3CA	PPP3CA	8232	0.027	0.49	NO
31	PIK3CA	PIK3CA	PIK3CA	8702	0.02	0.47	NO
32	PRKACG	PRKACG	PRKACG	8877	0.017	0.46	NO
33	PRKAR1B	PRKAR1B	PRKAR1B	9259	0.011	0.44	NO
34	CALM2	CALM2	CALM2	9674	0.0049	0.42	NO
35	LIF	LIF	LIF	9967	0.00088	0.4	NO
36	RAF1	RAF1	RAF1	10029	0.0001	0.4	NO
37	FKBP1A	FKBP1A	FKBP1A	10214	-0.0024	0.39	NO
38	MAPK3	MAPK3	MAPK3	10227	-0.0026	0.39	NO
39	MAPK1	MAPK1	MAPK1	10363	-0.0046	0.38	NO
40	MAPK14	MAPK14	MAPK14	10441	-0.0058	0.38	NO
41	AKT1	AKT1	AKT1	10625	-0.0084	0.37	NO
42	MAPK8	MAPK8	MAPK8	11387	-0.019	0.33	NO
43	NPPA	NPPA	NPPA	11706	-0.022	0.32	NO
44	RPS6KB1	RPS6KB1	RPS6KB1	12090	-0.027	0.3	NO
45	CALR	CALR	CALR	12222	-0.029	0.3	NO
46	CSNK1A1	CSNK1A1	CSNK1A1	12780	-0.037	0.27	NO
47	MAP2K1	MAP2K1	MAP2K1	13417	-0.045	0.24	NO
48	GSK3B	GSK3B	GSK3B	13858	-0.052	0.22	NO
49	HBEGF	HBEGF	HBEGF	15511	-0.083	0.15	NO
50	F2	F2	F2	16356	-0.11	0.11	NO
51	HRAS	HRAS	HRAS	16731	-0.12	0.11	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	FGF10	FGF10	FGF10	52	0.86	0.049	YES
2	ADCY5	ADCY5	ADCY5	120	0.79	0.093	YES
3	PDE1A	PDE1A	PDE1A	127	0.78	0.14	YES
4	FGF7	FGF7	FGF7	179	0.74	0.18	YES
5	ADCY2	ADCY2	ADCY2	185	0.74	0.23	YES
6	PDE1B	PDE1B	PDE1B	198	0.73	0.27	YES
7	FGF2	FGF2	FGF2	384	0.63	0.3	YES
8	KL	KL	KL	603	0.56	0.32	YES
9	PRKAR2B	PRKAR2B	PRKAR2B	879	0.5	0.34	YES
10	CAMK4	CAMK4	CAMK4	1069	0.47	0.36	YES
11	FGFR1	FGFR1	FGFR1	1321	0.43	0.37	YES
12	FGF5	FGF5	FGF5	1396	0.42	0.39	YES
13	AKT3	AKT3	AKT3	1433	0.41	0.41	YES
14	FGF18	FGF18	FGF18	1561	0.39	0.43	YES
15	ADCY4	ADCY4	ADCY4	1858	0.35	0.44	YES
16	IL17RD	IL17RD	IL17RD	2239	0.3	0.43	YES
17	PRKCG	PRKCG	PRKCG	2408	0.29	0.44	YES
18	FGF1	FGF1	FGF1	2553	0.27	0.45	YES
19	FGF9	FGF9	FGF9	2629	0.26	0.46	YES
20	ADCY1	ADCY1	ADCY1	3032	0.23	0.45	YES
21	PRKACB	PRKACB	PRKACB	3079	0.23	0.46	YES
22	GAB2	GAB2	GAB2	3264	0.21	0.47	YES
23	STAT5A	STAT5A	STAT5A	3465	0.19	0.47	YES
24	PIK3R1	PIK3R1	PIK3R1	3717	0.18	0.47	YES
25	ADCY9	ADCY9	ADCY9	3857	0.17	0.47	YES
26	FOXO4	FOXO4	FOXO4	4021	0.16	0.47	YES
27	ITPR2	ITPR2	ITPR2	4023	0.16	0.48	YES
28	STAT5B	STAT5B	STAT5B	4120	0.15	0.48	YES
29	FOXO1	FOXO1	FOXO1	4607	0.13	0.47	NO
30	FGF20	FGF20	FGF20	4726	0.12	0.47	NO
31	CDKN1B	CDKN1B	CDKN1B	5044	0.11	0.46	NO
32	GAB1	GAB1	GAB1	5246	0.1	0.45	NO
33	FGFR2	FGFR2	FGFR2	5416	0.094	0.45	NO
34	PRKCA	PRKCA	PRKCA	5424	0.093	0.45	NO
35	NR4A1	NR4A1	NR4A1	5640	0.087	0.45	NO
36	PRKCE	PRKCE	PRKCE	5652	0.086	0.45	NO
37	PTEN	PTEN	PTEN	5874	0.078	0.44	NO
38	PRKACA	PRKACA	PRKACA	5883	0.078	0.45	NO
39	FGFR1OP2	FGFR1OP2	FGFR1OP2	6130	0.071	0.44	NO
40	PLCG1	PLCG1	PLCG1	6668	0.057	0.42	NO
41	PRKAR2A	PRKAR2A	PRKAR2A	6694	0.056	0.42	NO
42	MAPKAP1	MAPKAP1	MAPKAP1	6743	0.054	0.42	NO
43	CBL	CBL	CBL	6944	0.05	0.41	NO
44	SPRY2	SPRY2	SPRY2	7085	0.047	0.4	NO
45	CALM3	CALM3	CALM3	7092	0.047	0.41	NO
46	BAD	BAD	BAD	7494	0.04	0.39	NO
47	AKT2	AKT2	AKT2	7538	0.039	0.39	NO
48	STAT3	STAT3	STAT3	7573	0.038	0.39	NO
49	ADCY6	ADCY6	ADCY6	7627	0.037	0.39	NO
50	ADCY7	ADCY7	ADCY7	7678	0.036	0.39	NO
51	PRKAR1A	PRKAR1A	PRKAR1A	7769	0.035	0.38	NO
52	CALM1	CALM1	CALM1	7817	0.034	0.38	NO
53	CASP9	CASP9	CASP9	7954	0.032	0.38	NO
54	CREB1	CREB1	CREB1	8057	0.03	0.38	NO
55	SOS1	SOS1	SOS1	8071	0.029	0.38	NO
56	TSC2	TSC2	TSC2	8168	0.028	0.37	NO
57	UBA52	UBA52	UBA52	8251	0.027	0.37	NO
58	PDPK1	PDPK1	PDPK1	8498	0.022	0.36	NO
59	FRS3	FRS3	FRS3	8630	0.021	0.35	NO
60	PIK3CA	PIK3CA	PIK3CA	8702	0.02	0.35	NO
61	FOXO3	FOXO3	FOXO3	8799	0.018	0.35	NO
62	PRKACG	PRKACG	PRKACG	8877	0.017	0.34	NO
63	CUX1	CUX1	CUX1	8979	0.015	0.34	NO
64	GRB2	GRB2	GRB2	9073	0.014	0.33	NO
65	ADCY8	ADCY8	ADCY8	9078	0.014	0.34	NO
66	FRS2	FRS2	FRS2	9246	0.011	0.33	NO
67	PRKAR1B	PRKAR1B	PRKAR1B	9259	0.011	0.33	NO
68	MKNK1	MKNK1	MKNK1	9332	0.0098	0.32	NO
69	STAT1	STAT1	STAT1	9407	0.0085	0.32	NO
70	RPS27A	RPS27A	RPS27A	9528	0.0069	0.31	NO
71	CALM2	CALM2	CALM2	9674	0.0049	0.31	NO
72	THEM4	THEM4	THEM4	9736	0.004	0.3	NO
73	BRAF	BRAF	BRAF	9777	0.0036	0.3	NO
74	MDM2	MDM2	MDM2	9919	0.0014	0.29	NO
75	FGF23	FGF23	FGF23	9988	0.00061	0.29	NO
76	RAF1	RAF1	RAF1	10029	0.0001	0.29	NO
77	AKT1S1	AKT1S1	AKT1S1	10089	-0.00061	0.28	NO
78	FGF22	FGF22	FGF22	10110	-0.00082	0.28	NO
79	MAPK3	MAPK3	MAPK3	10227	-0.0026	0.28	NO
80	RICTOR	RICTOR	RICTOR	10240	-0.0028	0.28	NO
81	PPP2CB	PPP2CB	PPP2CB	10303	-0.0037	0.27	NO
82	ADCY3	ADCY3	ADCY3	10333	-0.0041	0.27	NO
83	MAPK1	MAPK1	MAPK1	10363	-0.0046	0.27	NO
84	MLST8	MLST8	MLST8	10365	-0.0046	0.27	NO
85	AKT1	AKT1	AKT1	10625	-0.0084	0.26	NO
86	PPP2R1A	PPP2R1A	PPP2R1A	10647	-0.0088	0.26	NO
87	SHC1	SHC1	SHC1	10732	-0.01	0.25	NO
88	GSK3A	GSK3A	GSK3A	10942	-0.013	0.24	NO
89	FGFR4	FGFR4	FGFR4	11417	-0.019	0.22	NO
90	MAP2K2	MAP2K2	MAP2K2	11498	-0.02	0.22	NO
91	KLB	KLB	KLB	11719	-0.022	0.21	NO
92	YWHAB	YWHAB	YWHAB	12084	-0.027	0.19	NO
93	TRIM24	TRIM24	TRIM24	12103	-0.027	0.19	NO
94	MTOR	MTOR	MTOR	12188	-0.028	0.19	NO
95	ADRBK1	ADRBK1	ADRBK1	12436	-0.032	0.17	NO
96	PPP2CA	PPP2CA	PPP2CA	12740	-0.036	0.16	NO
97	KRAS	KRAS	KRAS	12775	-0.037	0.16	NO
98	FGF8	FGF8	FGF8	12804	-0.037	0.16	NO
99	MAP2K1	MAP2K1	MAP2K1	13417	-0.045	0.13	NO
100	ZMYM2	ZMYM2	ZMYM2	13594	-0.048	0.12	NO
101	CHUK	CHUK	CHUK	13617	-0.048	0.13	NO
102	CDKN1A	CDKN1A	CDKN1A	13711	-0.049	0.12	NO
103	CPSF6	CPSF6	CPSF6	13777	-0.05	0.12	NO
104	PRKCD	PRKCD	PRKCD	13877	-0.052	0.12	NO
105	BCR	BCR	BCR	13916	-0.052	0.12	NO
106	SRC	SRC	SRC	13949	-0.053	0.12	NO
107	MYO18A	MYO18A	MYO18A	14063	-0.055	0.12	NO
108	NRAS	NRAS	NRAS	15221	-0.077	0.064	NO
109	FGF17	FGF17	FGF17	15378	-0.08	0.06	NO
110	RPS6KB2	RPS6KB2	RPS6KB2	15386	-0.08	0.065	NO
111	FGF3	FGF3	FGF3	15537	-0.084	0.062	NO
112	PHLPP1	PHLPP1	PHLPP1	16059	-0.098	0.04	NO
113	FGF4	FGF4	FGF4	16634	-0.12	0.016	NO
114	HRAS	HRAS	HRAS	16731	-0.12	0.019	NO
115	FGFR1OP	FGFR1OP	FGFR1OP	16981	-0.14	0.014	NO
116	ITPR3	ITPR3	ITPR3	17147	-0.15	0.014	NO
117	FGF19	FGF19	FGF19	17484	-0.17	0.0064	NO
118	CDK1	CDK1	CDK1	18021	-0.24	-0.0081	NO
119	TRIB3	TRIB3	TRIB3	18330	-0.29	-0.0069	NO
120	FGFR3	FGFR3	FGFR3	18676	-0.46	0.0026	NO