PARADIGM pathway analysis of mRNA expression and copy number data
Pan-kidney cohort (KICH+KIRC+KIRP) (Primary solid tumor)
28 January 2016  |  analyses__2016_01_28
Maintainer Information
Citation Information
Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Cite as Broad Institute TCGA Genome Data Analysis Center (2016): PARADIGM pathway analysis of mRNA expression and copy number data. Broad Institute of MIT and Harvard. doi:10.7908/C1HD7V2R
- Overview
+ Introduction
- Summary

There were 53 significant pathways identified in this analysis.

Table 1.  Get Full Table Top 10 out of 131 pathways in order of significance.

Pathway.Name Avg.Num.Perturbations
HIF-1-alpha transcription factor network 24
Endothelins 20
VEGFR1 specific signals 17
Signaling events mediated by VEGFR1 and VEGFR2 16
HIF-2-alpha transcription factor network 15
EGFR-dependent Endothelin signaling events 11
IL12-mediated signaling events 10
Thromboxane A2 receptor signaling 10
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 10
IL23-mediated signaling events 10
- Results
+ Summary Table
+ Inferred Pathway Levels Matrix
+ Methods & Data