PARADIGM pathway analysis of mRNASeq expression data
Uveal Melanoma (Primary solid tumor)
28 January 2016  |  analyses__2016_01_28
Maintainer Information
Citation Information
Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Cite as Broad Institute TCGA Genome Data Analysis Center (2016): PARADIGM pathway analysis of mRNASeq expression data. Broad Institute of MIT and Harvard. doi:10.7908/C1VT1RMN
- Overview
+ Introduction
- Summary

There were 41 significant pathways identified in this analysis.

Table 1.  Get Full Table Top 10 out of 131 pathways in order of significance.

Pathway.Name Avg.Num.Perturbations
TCR signaling in naïve CD8+ T cells 21
IL12-mediated signaling events 16
Class IB PI3K non-lipid kinase events 15
Signaling events regulated by Ret tyrosine kinase 14
Endothelins 12
Syndecan-1-mediated signaling events 10
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 10
Visual signal transduction: Rods 10
JNK signaling in the CD4+ TCR pathway 9
Ephrin B reverse signaling 9
- Results
+ Summary Table
+ Inferred Pathway Levels Matrix
+ Methods & Data